CN102961648A - Chinese herbal medicine compound preparation for treating advanced colorectal cancer - Google Patents
Chinese herbal medicine compound preparation for treating advanced colorectal cancer Download PDFInfo
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Abstract
The invention relates to the technical field of traditional Chinese medicine, and in particular relates to a Chinese herbal medicine compound preparation for treating advanced colorectal cancer. The Chinese herbal medicine compound preparation is characterized by comprising the following active ingredients by weight ratio: 30g of radix astragali, 15g of atractylodes macrocephala koidz, 30g of sargentgloryvine stem, 21g of radix codonopsis, 30g of poria cocos, 30g of coix seeds, 12g of cortex magnoliae officinalis, 18g of radix paeoniae alba, 18g of cortex ailanthi, 12g of myristica fragrans, 18g of artemisia anomala, 21g of sculellaria barbata, 30g of herba Hedyrotidis diffusae, 30g of rhizoma polygonatum and 6g of radix glycyrrhizae, and the active ingredients are prepared into capsules. The Chinese herbal medicine compound preparation has the advantages of being obvious in curative effect, safe and cheap, tonifying qi and spleen, clearing dampness and resolving turbidity, removing qi stagnation and removing stasis, and the like.
Description
Technical field
The present invention relates to a kind of technical field of Chinese medicines, specifically a kind of compound Chinese medicinal preparation that detoxifcation potentiation is arranged that advanced CRC is treated.
Background technology
Colorectal cancer is one of clinical common malignant tumor, and annual new cases 102.3 ten thousand people in the whole world account for 9.4% of all malignant tumor according to statistics, occupy the 3rd; Annual dead 52.9 ten thousand people occupy the 4th; Be in first of the malignant tumor of digestive tract at its sickness rate of American-European countries, China's incidence of colorectal every year approximately with 4.2% speed increase, become one of the healthy disease of serious harm compatriots [1].Concealment of colorectal cancer morbidity, about 25% patient has belonged to late period when medical, treats still take chemotherapy as main at present for advanced CRC.And third generation platinum class and irinotecan get permission to treat colorectal cancer in succession, and especially the latter has become one of choice drug for the treatment of advanced CRC.Along with continuing to bring out of active drug, the median survival interval of advanced CRC can reach more than 2 years, but when long-term chemotherapy prolongs life cycle, how to alleviate chemotherapy toxic side effect, improving the Chemotherapy in Patients toleration, guarantee its quality of life, is the focus that the clinical tumor doctor pays close attention to.Chinese medicine occupies critical role in the Comprehensive Treatment of colorectal cancer late with its unique organism thinking, treatment theory and effective formula and drug, and especially the aspect plays a significant role alleviating chemotherapy toxic side effect and improve the quality of living etc.Studies show that in a large number Chinese medicine both can be worked in coordination with the chemotherapy killing off tumor cells in the PATIENTS WITH LARGE BOWEL Comprehensive Treatment, strengthen the sensitivity of chemotherapy, can alleviate its toxic and side effects again, improve therapeutic effect, reduce the Recurrence and metastatic rate of colorectal cancer, improve simultaneously Quality of Life.As seen, Chinese medicine has become the indispensable part of colorectal cancer Comprehensive Treatment.
Summary of the invention
The objective of the invention is to solve above-mentioned the deficiencies in the prior art, provide that a kind of evident in efficacy, safe, inexpensive, replenishing QI to invigorate the spleen, damp eliminatingization are turbid, the compound Chinese medicinal preparation of the treatment advanced CRC of removing food stagnancy eliminating stagnation.
The technical solution adopted for the present invention to solve the technical problems is:
A kind of compound Chinese medicinal preparation for the treatment of advanced CRC; it is characterized in that crude drug of the present invention is to be made of following component by weight ratio: Radix Astragali 30g; Rhizoma Atractylodis Macrocephalae 15g; Caulis Sargentodoxae 30g; Radix Codonopsis 21g; Poria 30g; Semen Coicis 30g; Cortex Magnoliae Officinalis 12g; Radix Paeoniae Alba 18g; Cortex Ailanthi 18g; Semen Myristicae 12g; Herba Artemisiae Anomalae 18g; Herba Scutellariae Barbatae 21g; Herba Hedyotidis Diffusae 30g; Rhizoma Polygonati 30g and Radix Glycyrrhizae 6g; its manufacture method step is: with the Radix Astragali; the Rhizoma Atractylodis Macrocephalae; Caulis Sargentodoxae; Radix Codonopsis; Poria; Semen Coicis; Cortex Magnoliae Officinalis; the Radix Paeoniae Alba; Cortex Ailanthi; Semen Myristicae; Herba Artemisiae Anomalae; Herba Scutellariae Barbatae; Herba Hedyotidis Diffusae; Rhizoma Polygonati; Radix Glycyrrhizae is by the proportioning mix homogeneously; pack in the extractor; adding water did not have crude drug to soak half an hour; decocting and being condensed into proportion after 1.5 hours is 1.3 mastic; extract mastic; with mastic; dextrin; Icing Sugar in the ratio of 1:1:3 pour into stir in the blender after; in squeezing the grain machine, make the uniform granule of 10-14 order again; dry in 60 ° of C-80 ° of C environment; last packing; every bag of 10g, three times on the one.
Instructions of taking: the 10g/ bag, every bu early, middle and late three times oral.
The present invention taboo: the anemia of pregnant woman, bleeding tendency person's forbidding is arranged.The careful usefulness of Liver and kidney merit severely subnormal person.
Prescription solution among the present invention is:
Compatibility: monarch: the Radix Astragali; Minister: the Rhizoma Atractylodis Macrocephalae, Caulis Sargentodoxae; Assistant: Radix Codonopsis, Poria, Semen Coicis, Cortex Magnoliae Officinalis, the Radix Paeoniae Alba, Cortex Ailanthi, Semen Myristicae, Herba Artemisiae Anomalae, Herba Scutellariae Barbatae, Herba Hedyotidis Diffusae, Rhizoma Polygonati; Make: Radix Glycyrrhizae.
Prescription analysis:
The Radix Astragali: sweet, tepor is returned spleen, lung meridian, has the effect that tonifying Qi and lifting yang, benefit are defended consolidating superficial resistance, inducing diuresis to remove edema, holder skin ulcer granulation promoting, can be used for treating deficiency of spleen-QI and stomach-QI, sinking of QI of middle-JIAO, exterior deficiency spontaneous perspiration, insufficiency of lung-QI diseases caused by exogenous pathogenic factor, the deficiency of vital energy water edema that wets, carbuncle is difficult bursts, and bursts for a long time and does not hold back Qi and blood deficiency etc.Select the Radix Astragali to control " consumptive disease with abdominal contraction, various symptoms and signs of deficiency " in the Zhang Zhongjing " Medical Treasures of the Golden Chamber ".Materia Medica of Decoction cloud: " tonifying five ZANG-organs is all empty not enough "." pearl sac ": " the sweet temperature of the Radix Astragali is pure, and it is with having five: mend all empty deficiencies, one also; Benefit vigour, two also; Strong taste, three also; The flesh heat of dispelling, four also; The evacuation of pus pain relieving, the hemopoietic of invigorating blood circulation, the expelling the toxic substance from the body with tonic carbuncle of yin nature is persons particularly liable to develop skin infection's panacea, five also ".Modern pharmacological research shows that astragalus polysaccharides is the main effective ingredient of antineoplastic in the Radix Astragali, can improve on the one hand body's immunity and stimulate bone marrow hematogenesis, but direct killing tumor cell on the other hand;
The Rhizoma Atractylodis Macrocephalae: bitter in the mouth, sweet, warm in nature; The master enters spleen channel, and the key medicine for the treatment syndrome of spleen-deficiency has and middle QI invigorating the effect of invigorating the spleen and stomach.Li Zhongzi: " Tu Wang then can be good for fortune for the Rhizoma Atractylodis Macrocephalae, the key medicine of tonifying the spleen and stomach, thus mass in the abdomen person is arranged, can not the trencherman, food stagnation person, all use also ".Rhizoma Atractylodis Macrocephalae volatile oil and polysaccharide are its main chemical compositions, and research finds that 100% Rhizoma Atractylodis Macrocephalae injection in suppressing the S180 solid tumor, not only can reduce the aggressive of the rate of increase and the tumor tissue of tumor cell, can also improve the antitumor respond of body;
Caulis Sargentodoxae: hardship, flat, return large intestine channel; Effect heat-clearing and toxic substances removing, promoting blood circulation and stopping pain, the stasis of blood stagnates in the kind loose intestinal, for controlling the key medicine of acute appendicitis; And Jing-Yue Complete Works proposes for a long time to control the special side-Caulis Sargentodoxae of acute appendicitis and fries in shallow oil.This product extracting solution prevents damaging intestinal adhesion effect, can significantly suppress enterokinesia speed, obviously anticoagulant and its depolymerization of promotion, and modern pharmacological research shows that it has preferably bacteriostasis and definite antitumor action;
Radix Codonopsis: sweet in the mouth, property is flat, returns lung, spleen channel; Has strengthening the spleen and tonifying the lung, the effect of supplementing QI for promoting the production of body fluid; " modern pharmacological research shows that the effective ingredient of Radix Codonopsis has obvious function of tumor inhibition, and have bibliographical information to adopt the Radix Codonopsis polysaccharide of variable concentrations in the experiment of S180 tumor suppression, effect to be arranged all, the result shows that the middle and high concentration dose group of Radix Codonopsis has inhibitory action all above 30% to the S180 tumor, and antitumor mechanism that inquire into to analyze Radix Codonopsis may be to realize by the immunologic function of removing the free radical in the body and improving body;
Poria: sweet in the mouth, light, property is flat.GUIXIN, spleen, lung, kidney channel have promoting diuresis to eliminate damp pathogen, invigorating the spleen and regulating the stomach, and the effect of mind tranquilizing and the heart calming, modern study finds that the Poria antitumor action mainly is that its main component pachyman plays a role, thus the propagation of inhibition tumor cell and killing tumor cell; Also can realize that it is to the direct killing effect of tumor cell by the synthetic of inhibition tumor cell DNA, RNA;
Semen Coicis: sweet, light, be slightly cold, return taste, lung meridian; Effect promoting diuresis to eliminate damp pathogen, spleen invigorating eliminating impediment, clearing away heat and discharging pus, modern pharmacological research find that the Semen Coicis decoction has certain effect to anticancer;
Cortex Magnoliae Officinalis: bitter, hot, warm, return taste, large intestine, lung meridian; The effect of have circulation of qi promoting, dampness, removing food stagnancy, relievining asthma is the key medicine of eliminating distension.Its active ingredient Cortex Magnoliae Officinalis magnolol has obvious active anticancer;
The Radix Paeoniae Alba: bitter, sour, be slightly cold, return liver, spleen channel; Has the yin fluid astringing of nourishing blood, easing the affected liver to relieve pain, the effect of suppressing liver-YANG.Pharmacological research shows that peoniflorin has preferably spasmolysis and certain calmness, analgesic activity, and white peony root's total glycoside has the effect of the immunne response of adjusting to mice;
Cortex Ailanthi: bitter in the mouth, cold in nature, effect heat clearing and damp drying, astringing to arrest diarrhea, hemostasis.Its active ingredient Azedarachin can promote enterokinesia quickening and juice to increase, and guassin and ailanthinone have antitumaous effect, and the mouse lymphocyte leukemia P388 is had inhibitory action;
Semen Myristicae: hot, warm, return spleen, stomach, large intestine channel; Effect relieving diarrhea with astringents, warming middle-JIAO to promote flow of QI.And modern pharmacological research finds that its contained volatile oil not only has fragrant stomach invigorating and wind dispelling effect, also has certain antibacterial action;
Herba Artemisiae Anomalae: bitter, warm, have the effect of promoting blood circulation and stopping pain, eliminate indigestion antidiarrheal, hemostasis, healing up sore and subduing swelling;
Herba Scutellariae Barbatae: acrid in the mouth, hardship, cold in nature, return lung, liver, kidney channel, have heat-clearing and toxic substances removing, the effect of heat-clearing and toxic substances removing, blood circulation promoting and blood stasis dispelling, reducing swelling and alleviating pain.The antitumor curative effect of Herba Scutellariae Barbatae is affirmed in clinical observation, even treat the late tumor patient of weary art, the effect that also is improved patient's symptom, improves the quality of living and prolongs life cycle;
Herba Hedyotidis Diffusae: full name Herba Hedyotidis Diffusae, effect heat-clearing and toxic substances removing, dispersing accumulated pathogens to resolve the mass, relieving stranguria by diuresis.Modern pharmacological research shows: Herba Hedyotidis Diffusae be generally acknowledge in recent years have one of Chinese medicine of obvious antitumor action, its can activated T lymphocytes, the kill tumor cell; Stimulate reticuloendothelial system to reach the immune defense function purpose that improves leukocytic phagocytic activity and enhancing body;
Rhizoma Polygonati: sweet, flat, return lung, spleen, kidney channel, have the effect of nourishing kidney lung moistening, invigorating the spleen and replenishing QI, dirtyly enjoy clinical favor, modern pharmacological research to confirm that also it is remarkable in enhancing immunologic function, resisting fatigue, anoxia enduring and the aspect effect such as antibacterial with mending because of three;
Radix Glycyrrhizae: sweet, flat, effect invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription, modern pharmacological research show that it has obvious antiinflammatory action, and all have dual regulation in square medicine combination, prescription, immunity;
The present invention cures mainly the temper virtual loss, the wet mutual junction type intestinal of the stasis of blood is long-pending, and is square take the Radix Astragali as monarch drug, because The spleen and stomach provide the material basis of the acquired, and source of generating QI and blood, but take the Radix Astragali as monarch's invigorating the spleen and replenishing QI, operation Central Region, all dirty getting profit; The ministerial drug Rhizoma Atractylodis Macrocephalae has the effect of replenishing QI to invigorate the spleen, dampness diuretic, is described as " air making-up and spleen enlivening the first key medicine "; Caulis Sargentodoxae is for the key medicine for the treatment of acute appendicitis, as ministerial drug, can not only heat-clearing and toxic substances removing, and again can promoting blood circulation to remove obstruction in the collateral, the removing food stagnancy eliminating stagnation; The two and monarch drug compatibility can reinforcing body resistance again can the damp eliminating eliminating stagnation, played the effect for the treatment of both the principal and secondary aspects of a disease.Assistant is with Radix Codonopsis, Poria, Semen Coicis air making-up and spleen enlivening; Cortex Magnoliae Officinalis, the Radix Paeoniae Alba, Cortex Ailanthi, Semen Myristicae removing dampness turbid, the astringing to arrest diarrhea of dispelling, Herba Hedyotidis Diffusae, Herba Scutellariae Barbatae, Herba Artemisiae Anomalae detoxification and removing stasis, removing food stagnancy eliminating stagnation; Rhizoma Polygonati tonification lung spleen kidney, boosting qi and nourishing yin, all medicines of using corrigent consume the fraud of the moon of feeling frustrated, and play assistant and making it effect.Radix Glycyrrhizae is for making medicine with coordinating the actions of various ingredients in a prescription.Take a broad view of full side, prescription is rigorous, and compatibility is reasonable, and YAOJING power is special, plays altogether that replenishing QI to invigorate the spleen, damp eliminatingization are turbid, the effect of removing food stagnancy eliminating stagnation.And a large amount of modern pharmacological researches confirms that our contained drug can pass through different mechanisms, the anticancer cancer suppressing action of performance in various degree.
The specific embodiment:
A kind of compound Chinese medicinal preparation for the treatment of advanced CRC; it is characterized in that crude drug of the present invention is to be made of following component by weight ratio: Radix Astragali 30g; Rhizoma Atractylodis Macrocephalae 15g; Caulis Sargentodoxae 30g; Radix Codonopsis 21g; Poria 30g; Semen Coicis 30g; Cortex Magnoliae Officinalis 12g; Radix Paeoniae Alba 18g; Cortex Ailanthi 18g; Semen Myristicae 12g; Herba Artemisiae Anomalae 18g; Herba Scutellariae Barbatae 21g; Herba Hedyotidis Diffusae 30g; Rhizoma Polygonati 30g and Radix Glycyrrhizae 6g; concrete manufacture method: with the Radix Astragali; the Rhizoma Atractylodis Macrocephalae; Caulis Sargentodoxae; Radix Codonopsis; Poria; Semen Coicis; Cortex Magnoliae Officinalis; the Radix Paeoniae Alba; Cortex Ailanthi; Semen Myristicae; Herba Artemisiae Anomalae; Herba Scutellariae Barbatae; Herba Hedyotidis Diffusae; Rhizoma Polygonati; Radix Glycyrrhizae is by the proportioning mix homogeneously; pack in the extractor; adding water did not have crude drug to soak half an hour; decocting and being condensed into proportion after 1.5 hours is 1.3 mastic; take out mastic; with mastic; dextrin; Icing Sugar in the ratio of 1:1:3 pour into stir in the blender after; in squeezing the grain machine, make the uniform granule of 10-14 order again; dry in 60 ° of C-80 ° of C environment; last packing; every bag of 10g, three times on the one.
Instructions of taking: the 10g/ bag, every bu early, middle and late three times oral.
The present invention taboo: the anemia of pregnant woman, bleeding tendency person's forbidding is arranged.The careful usefulness of Liver and kidney merit severely subnormal person.
The clinical efficacy for the treatment of advanced CRC is summed up:
One, physical data
Through 300 routine clinical treatments, simple Chinese patent drugs for treatment 180 examples wherein, combined chemotherapy 120 examples.
Two, diagnostic criteria
The PATIENTS WITH LARGE BOWEL of making a definite diagnosis through clinical, tissue or cytopathology, and be can't excision or only go the IV phase patient of palliative operation or postoperative recurrence, transfer; Diagnostic criteria with " temper virtual loss, the wet stasis of blood are tied mutually " tcm syndrome: (1) primary symptom: lack of appetite is indigestion and loss of appetite, fatigue and asthenia, abdominal pain and distension, the stagnant not well or frequency in large loose stool.(2) inferior disease: shallow complexion, spiritlessness and sparing of words, tastelessness and no thirst, gastral cavity is vexed, and light red tongue is fat or purple ecchymosis, petechia arranged secretly, and tongue is greasy, thready pulse without strength in vain.Diagnosis person should possess 2 of primary symptoms or 1 of primary symptom adds 2 of time diseases.
Three, instructions of taking
Take compound preparation of the present invention, early, middle and late three times of every bu, each 1 bag, one month is a course for the treatment of.
Four, efficacy assessment standard:
1, tcm syndrome efficacy assessment standard: " new Chinese medicine guideline of clinical investigations " [3] with reference to Zheng Xiao cornel chief editor draft TCM symptom score standard (seeing appendix 2), Estimating curative effect is used integration method, the weight of the degree that has that it's too late of symptom is score basis, and the relatively variation before and after the treatment.(1) produce effects: clinical traditional Chinese medical science disease integration descends 〉=70%; (2) effective: clinical traditional Chinese medical science disease integration descends 〉=30%; (3) invalid: clinical traditional Chinese medical science disease integration decline＜30% or rising.Effective percentage=[produce effects (n)+effectively (n)/sum (n)] * 100%.
2, quality of life (1) body weight change: 1. increase: body weight increase 〉=lkg after the treatment before the treatment; 2. stable: as to increase or reduce not enough lkg after the treatment; 3. descend: lose weight 〉=lkg after the treatment before the treatment.(2) KPS scoring: 1. raises with reference to Karnofsky point system (seeing appendix 3): before the treatment after the treatment KPS mark increase 〉=10 minutes; 2. stable: less than was increased or reduced to the KPS scoring 10 minutes after the treatment; 3. descend: the rear KPS scoring for the treatment of reduces 〉=10 minutes before the treatment.
Five, therapeutic effect
A month course for the treatment of, course for the treatment of of the lighter, severe one can take a turn for the better or cure two to three courses for the treatment of.
Among the 300 routine patients, 240 examples that take a turn for the better, invalid 60 examples, effective percentage 80%.
The present invention taboo: the anemia of pregnant woman, bleeding tendency person's forbidding is arranged.The careful usefulness of Liver and kidney merit severely subnormal person.
Six, model case
1, patient Han Song, the woman, 58 years old, Yantai Fushan District people, main suit's cancer patients half a year, after the multicycle chemotherapy, examine more than January abdominal distention, loose stool, takes course for the treatment of of the present invention, and not recurrence in a year is followed up a case by regular visits in the symptom complete obiteration.
2, patient Liu Ming, man, 72 years old, Yantai Zhifu District people, the main suit: rectal cancer hepatic metastases in late period is examined, the Multiple Hospitalization chemotherapy, and therapeutic scheme is taken the parallel FORFIRI scheme chemotherapy of this product, after the 4 cycle chemotherapy, the chemotherapeutic period patient without obvious chemotherapy toxic side effect I, without special toxicity---Delayed onset is suffered from diarrhoea, and patients ' life quality obviously improves, the Ka Shi scoring rose to 90 minutes by 70 minutes, and tumor markers obviously descends.End of chemotherapy continues to take two courses for the treatment of of the present invention, periodic review, and 1 year so far stable disease gets nowhere.
3, patient Li Gang, man, 56 years old, people from urban district, Weihai, main suit's cancer patients (IIa phase) is gone chemicotherapy, because of abdominal distention, poor appetite, become thin to examine, takes 3 courses for the treatment of of the present invention, again from having taken 2 courses for the treatment of, regularly have a medical check-up, so far stable disease after the symptom complete obiteration.
Prescription solution among the present invention is:
The Radix Astragali: have the effect that tonifying Qi and lifting yang, benefit are defended consolidating superficial resistance, inducing diuresis to remove edema, holder skin ulcer granulation promoting; The Rhizoma Atractylodis Macrocephalae: the key medicine for the treatment syndrome of spleen-deficiency has and middle QI invigorating the effect of invigorating the spleen and stomach; Caulis Sargentodoxae: effect heat-clearing and toxic substances removing, promoting blood circulation and stopping pain, the stasis of blood stagnates in the kind loose intestinal, for controlling the key medicine of acute appendicitis; Radix Codonopsis: have strengthening the spleen and tonifying the lung, the effect of supplementing QI for promoting the production of body fluid; Cure mainly weakness of the spleen and stomach, anorexia and loose stool, limbs fatigue, cough and asthma due to lung deficiency, the spontaneous perspiration of breathing hard, all diseases of deficiency of both QI and blood; Poria: have promoting diuresis to eliminate damp pathogen, invigorating the spleen and regulating the stomach, the effect of mind tranquilizing and the heart calming; Semen Coicis: effect promoting diuresis to eliminate damp pathogen, spleen invigorating eliminating impediment, clearing away heat and discharging pus, Cortex Magnoliae Officinalis: the effect of have circulation of qi promoting, dampness, removing food stagnancy, relievining asthma is the key medicine of eliminating distension.The Radix Paeoniae Alba: have the yin fluid astringing of nourishing blood, easing the affected liver to relieve pain, the effect of suppressing liver-YANG.Cortex Ailanthi: heat clearing and damp drying, astringing to arrest diarrhea, hemostasis; Semen Myristicae: relieving diarrhea with astringents, warming middle-JIAO to promote flow of QI; Herba Artemisiae Anomalae: the effect with promoting blood circulation and stopping pain, eliminate indigestion antidiarrheal, hemostasis, healing up sore and subduing swelling; Herba Scutellariae Barbatae: have heat-clearing and toxic substances removing, the effect of heat-clearing and toxic substances removing, blood circulation promoting and blood stasis dispelling, reducing swelling and alleviating pain.Herba Hedyotidis Diffusae: effect heat-clearing and toxic substances removing, dispersing accumulated pathogens to resolve the mass, relieving stranguria by diuresis; Rhizoma Polygonati: the effect of nourishing kidney lung moistening, invigorating the spleen and replenishing QI, Radix Glycyrrhizae: invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.
The present invention cures mainly the temper virtual loss, the wet mutual junction type intestinal of the stasis of blood is long-pending, and is square take the Radix Astragali as monarch drug, because The spleen and stomach provide the material basis of the acquired, and source of generating QI and blood, but take the Radix Astragali as monarch's invigorating the spleen and replenishing QI, operation Central Region, all dirty getting profit; The ministerial drug Rhizoma Atractylodis Macrocephalae has the effect of replenishing QI to invigorate the spleen, dampness diuretic, is described as " air making-up and spleen enlivening the first key medicine "; Caulis Sargentodoxae is for the key medicine for the treatment of acute appendicitis, as ministerial drug, can not only heat-clearing and toxic substances removing, and again can promoting blood circulation to remove obstruction in the collateral, the removing food stagnancy eliminating stagnation; The two and monarch drug compatibility can reinforcing body resistance again can the damp eliminating eliminating stagnation, played the effect for the treatment of both the principal and secondary aspects of a disease.Assistant is with Radix Codonopsis, Poria, Semen Coicis air making-up and spleen enlivening; Cortex Magnoliae Officinalis, the Radix Paeoniae Alba, Cortex Ailanthi, Semen Myristicae removing dampness turbid, the astringing to arrest diarrhea of dispelling, Herba Hedyotidis Diffusae, Herba Scutellariae Barbatae, Herba Artemisiae Anomalae detoxification and removing stasis, removing food stagnancy eliminating stagnation; Rhizoma Polygonati tonification lung spleen kidney, boosting qi and nourishing yin, all medicines of using corrigent consume the fraud of the moon of feeling frustrated, and play assistant and making it effect.Radix Glycyrrhizae is for making medicine with coordinating the actions of various ingredients in a prescription.Take a broad view of full side, prescription is rigorous, and compatibility is reasonable, and YAOJING power is special, plays altogether that replenishing QI to invigorate the spleen, damp eliminatingization are turbid, the effect of removing food stagnancy eliminating stagnation.And a large amount of modern pharmacological researches confirms that our contained drug can pass through different mechanisms, the anticancer cancer suppressing action of performance in various degree.Treatment temper virtual loss, the wet stasis of blood are tied mutually " the type advanced CRC, can mitigation symptoms, the treatment of making the life better improves immunity of organisms, prolongation life cycle.Combined chemotherapy can attenuation synergistic, improves chemotherapeutic efficacy.And have the advantages such as evident in efficacy, safe, inexpensive, easy to use.
Claims (1)
1. compound Chinese medicinal preparation for the treatment of advanced CRC; it is characterized in that crude drug of the present invention is to be made of following component by weight ratio: Radix Astragali 30g; Rhizoma Atractylodis Macrocephalae 15g; Caulis Sargentodoxae 30g; Radix Codonopsis 21g; Poria 30g; Semen Coicis 30g; Cortex Magnoliae Officinalis 12g; Radix Paeoniae Alba 18g; Cortex Ailanthi 18g; Semen Myristicae 12g; Herba Artemisiae Anomalae 18g; Herba Scutellariae Barbatae 21g; Herba Hedyotidis Diffusae 30g; Rhizoma Polygonati 30g and Radix Glycyrrhizae 6g; its manufacture method step is: with the Radix Astragali; the Rhizoma Atractylodis Macrocephalae; Caulis Sargentodoxae; Radix Codonopsis; Poria; Semen Coicis; Cortex Magnoliae Officinalis; the Radix Paeoniae Alba; Cortex Ailanthi; Semen Myristicae; Herba Artemisiae Anomalae; Herba Scutellariae Barbatae; Herba Hedyotidis Diffusae; Rhizoma Polygonati; Radix Glycyrrhizae is by the proportioning mix homogeneously; pack in the extractor; adding water did not have crude drug to soak half an hour; decocting and being condensed into proportion after 1.5 hours is 1.3 mastic; take out mastic; with mastic; dextrin; Icing Sugar in the ratio of 1:1:3 pour into stir in the blender after; in squeezing the grain machine, make the uniform granule of 10-14 order again; dry in 60 ° of C-80 ° of C environment, last packing.
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| CN105233087A (en) * | 2015-11-12 | 2016-01-13 | 王亚芳 | Traditional Chinese medicine combination for being matched with chemotherapy for treating advanced large intestine cancer |
| CN105535839A (en) * | 2016-01-13 | 2016-05-04 | 青岛市肿瘤医院 | Traditional Chinese medicine tablets for treating colon cancer and preparation method thereof |
| CN105833018A (en) * | 2016-06-14 | 2016-08-10 | 青岛云天生物技术有限公司 | Medicine preparation for treating colorectal cancer and purpose thereof |
| CN105902964A (en) * | 2016-05-30 | 2016-08-31 | 刘志威 | Chinese medicinal decoction for treatment of intestinal cancer and preparation method thereof |
| CN105963476A (en) * | 2016-05-11 | 2016-09-28 | 张士舜 | Traditional Chinese medicine composition for treating colorectal cancer and preparation method thereof |
| CN109655606A (en) * | 2019-01-11 | 2019-04-19 | 华东师范大学 | It is a kind of to evaluate the enterotoxication detection method of drug using 3D organoid |
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| CN1651004A (en) * | 2004-12-23 | 2005-08-10 | 吴梅春 | Compound ginseng tea preparation for treating chronic pelvic cavity inflammation and its preparation method |
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1651004A (en) * | 2004-12-23 | 2005-08-10 | 吴梅春 | Compound ginseng tea preparation for treating chronic pelvic cavity inflammation and its preparation method |
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| CN104825922B (en) * | 2015-05-18 | 2018-04-03 | 南京中医药大学 | Chinese medicine composition with anti-colorectal carcinoma activity and its preparation method and application |
| CN105233087A (en) * | 2015-11-12 | 2016-01-13 | 王亚芳 | Traditional Chinese medicine combination for being matched with chemotherapy for treating advanced large intestine cancer |
| CN105535839A (en) * | 2016-01-13 | 2016-05-04 | 青岛市肿瘤医院 | Traditional Chinese medicine tablets for treating colon cancer and preparation method thereof |
| CN105963476A (en) * | 2016-05-11 | 2016-09-28 | 张士舜 | Traditional Chinese medicine composition for treating colorectal cancer and preparation method thereof |
| CN105902964A (en) * | 2016-05-30 | 2016-08-31 | 刘志威 | Chinese medicinal decoction for treatment of intestinal cancer and preparation method thereof |
| CN105833018A (en) * | 2016-06-14 | 2016-08-10 | 青岛云天生物技术有限公司 | Medicine preparation for treating colorectal cancer and purpose thereof |
| CN109655606A (en) * | 2019-01-11 | 2019-04-19 | 华东师范大学 | It is a kind of to evaluate the enterotoxication detection method of drug using 3D organoid |
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