CN103623229B - 一种治疗慢性肾小球肾炎的中药 - Google Patents
一种治疗慢性肾小球肾炎的中药 Download PDFInfo
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Abstract
本发明涉及一种治疗慢性肾小球肾炎的中药，由以下重量配比的药材制备而成：冬葵果16份、珠芽蓼12份、心不干12份、芒种花20份、搬倒甑8份、红毛菍14份、红头翁16份、卵叶娃儿藤16份、疳积草10份、丁榔皮10份、矮卫矛14份、八角枫花14份、白花灯笼12份、兔耳草16份、蜈蚣七10份。临床实验证明，本发明能够安全有效治疗慢性肾小球肾炎。
Description
技术领域
本发明涉及一种中药，具体涉及一种治疗慢性肾小球肾炎的中药。
背景技术
慢性肾小球肾炎简称为慢性肾炎，系指蛋白尿、血尿、高血压、水肿为基本临床表现，起病方式各有不同，病情迁延，病变缓慢进展，可以不同程度肾功能减退，最终将发展为慢性肾衰竭的一组肾小球病。由于本组疾病的病理类型及病期不同，主要临床表现各不相同，疾病表现呈多样化。慢性肾小球肾炎是一组多病因的慢性肾小球病变为主的肾小球疾病，但多数患者病因不明，它可能是由于各种细菌、病毒或原虫等感染通过免疫机制、炎症介质因子及非免疫机制等引起本病。
对于慢性肾小球肾炎目前尚缺少公认安全有效的治疗药物。
本发明中药所涉及药材的研究现状如下：
冬葵果【来源】本品系蒙古族习用药材，为锦葵科植物冬葵Malva verticillata L.的干燥成熟果实。夏、秋二季果实成熟时采收，除去杂质，阴干。【功能主治】清热利尿，消肿。用于尿闭，水肿，口渴；尿路感染。
珠芽蓼【来源】蓼科植物珠芽蓼，以根状茎入药。秋季采挖，洗净晒干备用。【功能主治】清热解毒，散瘀止血。用于扁桃体炎，咽喉炎，肠炎，痢疾，白带，崩漏，便血；外用治跌打损伤，痈疖肿毒，外伤出血。
心不干【来源】为百合科开口箭属植物粗丝开口箭Tupistra pachynema Wanget Tang，以根状茎入药。秋季采挖，去须根，洗净切片晒干或鲜用。【功能主治】温中散寒，行气止痛。用于胃痛，跌打肿痛。
芒种花【来源】金丝桃科金丝桃属植物金丝梅Hypericum patulum Thunb.，以全草、或嫩枝叶及果实入药。夏季采嫩枝叶，秋季采果实，全株全年可采，鲜用或晒干。【功能主治】清热解毒，凉血止血，杀虫，止痒。全草：上呼吸道感染，肝炎，痢疾，肾炎。果：血崩，鼻衄。叶：外用治皮肤瘙痒，黄水疮。根：驱蛔虫。
搬倒甑【来源】蓝雪科角柱花属植物紫金莲和蓝雪花C. plumbaginoides Bunge，以根入药。夏秋采集，晒干。【功能主治】解痉，镇痛。用于胃炎，胃溃疡，胆道蛔虫症，胆囊炎及蛔虫病引起的疼痛。
红毛菍【来源】野牡丹科野牡丹属植物毛菍Melastoma sanguineum Sims，以根、叶入药。全年可采，根洗净切片晒干；叶晒干，研末。【功能主治】止血，止痢。用于便血，月经过多，腹泻；外用治创伤出血。
红头翁【来源】爵床科芦莉草属植物芦莉草Ruellia drymophila （Diels） Hand.-Mazz.，以全草入药。夏秋采收，洗净切碎，晒干。【功能主治】清热解毒，消肿止痛。用于急性扁桃体炎，腮腺炎，支气管炎，肺炎，淋巴结结核；外用治骨折，刀伤感染，疮毒脓肿。
卵叶娃儿藤【来源】萝藦科娃儿藤属植物卵叶娃儿藤，以根或全草入药。华南地区全年可采，长江以南地区秋季采收。洗净切段晒干或鲜用。【功能主治】祛风除湿，散瘀止痛，止咳定喘，解蛇毒。用于风湿筋骨痛，跌打肿痛，咳嗽，哮喘，毒蛇咬伤。
疳积草【来源】爵床科明萼草属植物孩儿草的全草。全年可采，洗净，鲜用或晒干。【功能主治】清热利湿，消积导滞。用于小儿疳积，消化不良，肝炎，肠炎，感冒，喉痛，眼结膜炎，颈淋巴结结核；外用治疖肿。
丁榔皮【来源】山茱萸科灯台树属植物梾木Cornus macrophylla Wall.，以树皮入药。夏季剥取较老树枝的皮，晒干。【功能主治】祛风止痛，舒筋活络。用于风湿筋骨痛，腰腿痛，肢体瘫痪。
矮卫矛【来源】为卫矛科植物矮卫矛的根、皮。秋后采收，洗净，切片，或剥皮晒干。【功能主治】祛风散寒；除湿通络。主风寒湿痹；关节肿痛；肢体麻木全年可采，节段晒干。
八角枫花【来源】为八角枫科植物八角枫或瓜木的花。植物形态详八角枫根条。6月采。【功能主治】《四川中药志》：治头风痛及胸腹胀满。研末，蒸鸡蛋服。
白花灯笼【来源】为马鞭草赪桐属植物白花灯笼.,以根或全株入药。全年可采，洗净，切片晒干。【功能主治】清热解毒，止咳定痛。用于感冒发热，咽喉炎，支气管炎，肺结核潮热，胃痛，疝痛；跌打损伤，疔疮疖肿。
兔耳草【来源】玄参科兔耳草属植物兔耳草和显茎兔耳草，以根或带根全草入药。7～9月采集带根状茎的全草，洗净切段晒干。【功能主治】清热解毒，降血压。用于急、慢性肝炎，高血压，乳腺癌。
蜈蚣七【来源】兰科杓兰属植物大花杓兰，以根、根状茎和花入药。秋季采挖，洗净晒干。 【功能主治】利尿消肿，活血祛瘀，祛风镇痛。用于全身浮肿，下肢水肿，小便不利，白带，风湿腰腿痛，跌打损伤。
发明内容
本发明旨在提供一种治疗慢性肾小球肾炎的中药，通过选择合适的药材及其配比，达到安全有效治愈慢性肾小球肾炎的目的。
为了达到上述目的，本发明采用以下技术方案：
一种治疗慢性肾小球肾炎的中药，其特征在于，由以下重量配比的药材制备而成：冬葵果16份、珠芽蓼12份、心不干12份、芒种花20份、搬倒甑8份、红毛菍14份、红头翁16份、卵叶娃儿藤16份、疳积草10份、丁榔皮10份、矮卫矛14份、八角枫花14份、白花灯笼12份、兔耳草16份、蜈蚣七10份。
下面结合临床实验数据说明本发明的有益效果：
1、一般资料
发明人2011年3月-2012年10月间共收集98例慢性肾小球肾炎的门诊患者，年龄40-58岁，病程1-3年。随机分为：治疗组75例，空白组23例。两组年龄、病情等资料无显著性差异，具有可比性。
2、试验方法
2.1治疗组口服本发明按照具体实施例1制得的胶囊，早晚各一次。疗程30天。
2.2空白组口服安慰剂胶囊，早晚各一次。疗程30天。
3、疗效标准与治疗结果
3.1疗效标准
痊愈：临床症状全部消失，试验室检查正常，愈后观察三个月未见复发。好转：临床症状减轻，病情得到控制，实验室检查改善或正常。无效：临床症状无明显好转或加重。
3.2治疗统计结果见表1。
表1 两组疗效比较
| 组别 | n | 痊愈 | 好转 | 无效 | 总有效率(%) | 不良反应例 |
| 治疗组 | 75 | 16（21.3%） | 47（62.7%) | 12（16%) | 84% | 0 |
| 空白组 | 23 | 0 | 3（13%） | 20（87%） | 13% | 0 |
可见，本发明制得的药物能够安全有效治疗慢性肾小球肾炎。
具体实施方式
为了更好地理解和实施本发明，下面结合具体实施例进一步说明本发明。
具体实施例1
称取：冬葵果16克、珠芽蓼12克、心不干12克、芒种花20克、搬倒甑8克、红毛菍14克、红头翁16克、卵叶娃儿藤16克、疳积草10克、丁榔皮10克、矮卫矛14克、八角枫花14克、白花灯笼12克、兔耳草16克、蜈蚣七10克，加8倍量水，煎煮1.5小时，过滤；滤渣加6倍量水，煎煮1小时，过滤；合并滤液，浓缩，干燥，装入胶囊壳，即得符合正常成人1天用量的胶囊剂。
用于治疗慢性肾小球肾炎。口服，每日分早晚两次服用。
具体实施例2
称取：冬葵果16克、珠芽蓼12克、心不干12克、芒种花20克、搬倒甑8克、红毛菍14克、红头翁16克、卵叶娃儿藤16克、疳积草10克、丁榔皮10克、矮卫矛14克、八角枫花14克、白花灯笼12克、兔耳草16克、蜈蚣七10克，加8倍量水，煎煮1.5小时，过滤；滤渣加6倍量水，煎煮1小时，过滤；合并滤液，浓缩，干燥，粉碎，即得符合正常成人1天用量的散剂。
用于治疗慢性肾小球肾炎。口服，每日分早晚两次服用。
具体实施例3
称取：冬葵果16克、珠芽蓼12克、心不干12克、芒种花20克、搬倒甑8克、红毛菍14克、红头翁16克、卵叶娃儿藤16克、疳积草10克、丁榔皮10克、矮卫矛14克、八角枫花14克、白花灯笼12克、兔耳草16克、蜈蚣七10克，加8倍量水，煎煮1.5小时，过滤；滤渣加6倍量水，煎煮1小时，过滤；合并滤液，浓缩，干燥，再加入适量糊精和矫味剂，按照本领域常规工艺制粒，包装，即可制得符合正常成人1天用量的颗粒剂。
用于治疗慢性肾小球肾炎。口服，每日分早晚两次服用。
Claims (1)
1.一种治疗慢性肾小球肾炎的中药，其特征在于，由以下重量配比的药材制备而成：冬葵果16份、珠芽蓼12份、心不干12份、芒种花20份、搬倒甑8份、红毛菍14份、红头翁16份、卵叶娃儿藤16份、疳积草10份、丁榔皮10份、矮卫矛14份、八角枫花14份、白花灯笼12份、兔耳草16份、蜈蚣七10份。
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