CN103610995A - 一种治疗牙龈炎的中药 - Google Patents
一种治疗牙龈炎的中药 Download PDFInfo
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Abstract
本发明涉及一种治疗牙龈炎的中药，它是由以下重量配比的原料药材制备而成：牛黄0.1份、三七草5份、山竹子5份、苦竹叶5份、白头翁5份、土鳖虫6份、筋骨草4份、檀香3份、铁苋3份、芙蓉花5份、瓜蒌2份、木通1份、大黄4份、黄柏4份、豆根4份、山楂3份、延胡索3份。临床实验证明，本发明能够安全有效治疗牙龈炎。
Description
技术领域
本发明涉及一种中药，具体涉及一种治疗牙龈炎的中药。
背景技术
围绕并覆盖在牙齿周围的软组织称为牙龈，发生于牙龈组织的急慢性炎症称为牙龈炎（gingivitis）。表现为牙龈出血，红肿，胀痛，继续发展侵犯硬组织，产生牙周炎，包括牙龈组织的炎症及全身疾病在牙龈的表现。目前牙龈炎治疗主要是应用手术和抗生素，疗效低，且副作用大。因此研究开发一种安全有效治疗牙龈炎的中药非常有临床实用价值。
本发明中药所涉及药材的研究现状如下：
牛黄：本品为牛科动物牛干燥的胆结石。【性味】甘，凉。【归经】归心、肝经。【功能主治】清心，豁痰，开窍，凉肝，息风，解毒。用于热病神昏，中风痰迷，惊痫抽搐，癫痫发狂，咽喉肿痛，口舌生疮，痈肿疔疮。【用法用量】 0.15～0.35g。
三七草：本品为菊科植物三七草的叶或全草。【性味】甘，平。【功能主治】活血，止血，解毒。损伤，衄血，咳血，吐血，乳痈，无名肿毒，毒虫螫伤。【用法用量】3～5g.
山竹子:本品为藤黄科藤黄属植物多花山竹子及岭南山竹子的干燥皮。【性味】苦、涩，凉。有小毒。【功能主治】消炎止痛，收敛生肌。用于肠炎，小儿消化不良，胃、十二指肠溃疡，溃疡病轻度出血，口腔炎，牙周炎；外用治烧烫伤，下肢溃疡，湿疹。【用法用量】1～5g。
苦竹叶：本品为禾本科植物苦竹的嫩叶。【性味】苦；寒。【归经】心；肝经。【功能主治】清心；利尿明目；解毒。主热病烦渴；失眠；小便短赤；口疮；目痛；失音；烫火伤。【用法用量】。6-12g。
白头翁：本品为毛茛科植物白头翁Pulsatilla chinensis （Bge.） Regel的干燥根。[性味】苦，寒。归胃、大肠经。【功能主治】清热解毒，凉血止痢。用于热毒血痢，阴痒带下，阿米巴痢。【用法用量】 9～15g。
土鳖虫：本品为鳖蠊科昆虫地鳖Eupolyphaga sinensis Walker 或冀地鳖Steleophaga plancyi（Boleny）的雌虫干燥体。【性味】咸，寒；有小毒。【归经】归肝经。【功能主治】破瘀血，续筋骨。用于筋骨折伤，瘀血经闭，症瘕痞块。【用法用量】 3～9g。
筋骨草：唇形科筋骨草属植物筋骨草Ajuga decumbens Thunb.的全草。【性味】味苦；性寒。【功能主治】清热解毒；凉血消肿。主咽喉肿痛；肺热咯血；跌打肿痛。【用法用量】内服：煎汤，15-30g。
檀香：本品为檀香科檀香属植物檀香Santalum album L.树干的心材。【性味】辛，温。【归经】归脾、胃、心、肺经。【功能主治】行气温中，开胃止痛。用于寒凝气滞，胸痛，腹痛，胃痛食少；冠心病，心绞痛。【用法用量】 2～5g。
铁苋：本品为大戟科植物铁苋菜的全草。【性味】苦；涩；凉。【归经】心；肺；大肠；小肠经。【功能主治】清热利湿；凉血解毒；消积。主痢疾；泄泻；吐血；衄血；尿血；崩漏；小儿疳积；痈疖疮疡；皮肤湿疹。【用法用量10-15g。
芙蓉花：为锦葵科植物木芙蓉的花。【性味】辛；微苦；凉。【归经】肺；心；肝经。【功能主治】清热解毒；凉血止血；消肿排脓。主肺热咳嗽；吐血；目赤肿痛；崩漏；白带；腹泻；腹痛；痈肿；疮疖；毒蛇咬伤；水火烫伤；跌打损伤。【用法用量】9-15g。
瓜蒌：本品为葫芦科植物栝楼Trichosanthes kirilowii Maxim. 或双边栝楼Trichosan-thes rosthornii Harms 的干燥成熟果实。【性味】甘、微苦、寒。【归经】归肺、胃、大肠经。【功能主治】清热涤痰，宽胸散结，润燥滑肠。用于肺热咳嗽，痰浊黄稠，胸痹心痛，结胸痞满，乳痈，肺痈，肠痈肿痛，大便秘结。【用法用量】 9～15g。
木通：本品为木通科植物木通、三叶木通或白木通的滕茎。【性味】苦；性寒。【归经】心；脾；肾；小肠；膀胱经。【功能主治】清热利尿；活血通脉。主小便赤赤；淋浊；水肿；胸中烦热；喉喉疼痛；口舌生疮；风湿痹痛；乳汁不通；经闭；痛经。【用法用量】3-6g。
大黄：本品为蓼科植物掌叶大黄Rheum palmatum L。、 唐古特大黄Rheum tanguticum Maxim。 ex Balf。或药用大黄Rheum officinale Baill。的干燥根及根茎。【性味】苦，寒。【归经】归脾、胃、大肠、肝、心包经。【功能主治】泻热通肠，凉血解毒，逐瘀通经。用于实热便秘，积滞腹痛，泻痢不爽，湿热黄疸，血热吐衄，目赤，咽肿，肠痈腹痛，痈肿疔疮，瘀血经闭，跌打损伤，外治水火烫伤；上消化道出血。酒大黄善清上焦血分热毒。用于目赤咽肿，齿龈肿痛。熟大黄泻下力缓，泻火解毒。用于火毒疮疡。大黄炭凉血化瘀止血。用于血热有瘀出血症。【用法用量】 3～30g。
黄柏：本品为芸香科植物黄皮树Phellodendron chinense Schneid.或黄檗Phellodendron amurense Rupr.的干燥树皮。【性味】苦，寒。【归经】归肾、膀胱经。【功能主治】清热燥湿，泻火除蒸，解毒疗疮。用于湿热泻痢，黄疸，带下，热淋，脚气，痿{辟}，骨蒸劳热，盗汗，遗精，疮疡肿毒，湿疹瘙痒。盐黄柏滋阴降火。用于阴虚火旺，盗汗骨蒸。【用法用量】 3～12g
豆根：本品为豆科木蓝属植物花木蓝Indigofera Kirilowii Maxim. ex Palibin，以根入药。【性味】苦，寒。【功能主治】清热解毒，消肿止痛，通便。用于咽喉肿痛，肺热咳嗽，黄疸，热结便秘；外用治痔疮肿痛，蛇虫咬伤。
山楂：本品为蔷薇科植物山楂或野山楂的果实。【性味】酸甘；微温；无毒。【归经】脾；胃；肝；肺经。【功能主治】消食积；化滞瘀。主饮食积滞，脘腹胀痛，泄泻痢疾，血瘀痛经，闭经，产后腹痛；恶露不尽。【用法用量】3-10g。
延胡索：本为罂粟科植物延胡索的块茎。【性味】辛；苦；温；无毒。【归经】肝；胃；心；肺；脾经。【功能主治】活血；散瘀；理气；止痛。主心腹腰膝诸痛；月经不调；症瘕；崩中；产后血晕；恶露不尽；跌打损伤。【用法用量】1-3g。
发明内容
本发明旨在提供一种治疗牙龈炎的中药，通过选择合适的药材及其配比，达到安全有效治愈牙龈炎的目的。
为了达到上述目的，本发明采用以下技术方案：
一种治疗牙龈炎的中药，其特征在于，它是由以下重量配比的原料药材制备而成：牛黄0.1份、三七草5份、山竹子5份、苦竹叶5份、白头翁5份、土鳖虫6份、筋骨草4份、檀香3份、铁苋3份、芙蓉花5份、瓜蒌2份、 木通1份、大黄4份、黄柏4份、豆根4份、山楂3份、延胡索3份。
下面结合临床实验数据说明本发明的有益效果：
1、一般资料
发明人2009年12月-2013年4月间共收集50例牙龈炎患者，年龄18-76岁，病程1-30天。随机分为：治疗组25例，对照组25例。两组性别、年龄等资料无显著性差异，具有可比性。
2、试验方法
2.1治疗方法
对照组服用抗生素阿莫西林和甲硝唑，按其说明书服用，疗程10天。
治疗组口服本发明按照具体实施例1制得的胶囊，每日2次。疗程10天。
2.2观察项目：实验前后，对疼痛，肿面大小、体温及血液生化指标化验记录。
3、疗效标准与治疗结果
3.1疗效标准
痊愈：临床症状全部消失，试验室检查正常，半年内未见复发。好转：临床症状减轻，实验室检查改善或正常。无效：临床症状、实验室检查无明显好转或加重。
3.2治疗统计结果见表1。
表1 两组疗效比较
| 组别 | n | 痊愈 | 好转 | 无效 | 不良反应例 | 总有效率(%) |
| 治疗组 | 25 | 20 | 3 | 2 | 1（4%） | 92% |
| 对照组 | 25 | 3 | 10 | 12 | 22（88%） | 52% |
可见，本发明制得的药物能够安全有效治疗牙龈炎。
具体实施方式
为了更好地理解和实施本发明，下面结合具体实施例进一步说明本发明。
具体实施例1
称取牛黄0.1g、三七草5g、山竹子5g、苦竹叶5g、白头翁5g、土鳖虫6g、筋骨草4g、檀香3g、铁苋3g、芙蓉花5g、瓜蒌2g、 木通1g、大黄4g、黄柏4g、豆根4g、山楂3g、延胡索3g，加8倍量水，煎煮1.5小时，过滤；滤渣加6倍量水，煎煮1小时，过滤；合并滤液，浓缩，干燥，装入胶囊壳，即得符合正常成人一天用量的胶囊剂。
用于治疗牙龈炎。口服，每日分早晚两次服用。
具体实施例2
称取称取牛黄0.1g、三七草5g、山竹子5g、苦竹叶5g、白头翁5g、土鳖虫6g、筋骨草4g、檀香3g、铁苋3g、芙蓉花5g、瓜蒌2g、 木通1g、大黄4g、黄柏4g、豆根4g、山楂3g、延胡索3g，加10倍量水，煎煮2小时，过滤；滤渣加8倍量水，煎煮1.5小时，过滤；合并滤液，浓缩，干燥，包装，即得符合正常成人一天用量的散剂。
用于治疗牙龈炎。口服，每日一次。
具体实施例3
称取称取牛黄0.1g、三七草5g、山竹子5g、苦竹叶5g、白头翁5g、土鳖虫6g、筋骨草4g、檀香3g、铁苋3g、芙蓉花5g、瓜蒌2g、 木通1g、大黄4g、黄柏4g、豆根4g、山楂3g、延胡索3g，加6倍量水，煎煮3次，每次煎煮1小时，合并煎煮液，浓缩，再加入适量糊精和矫味剂，按照本领域常规工艺制粒，包装，即可制得符合正常成人一天用量的颗粒剂。
用于治疗牙龈炎。口服，每日分早中晚三次服用。
Claims (1)
1.一种治疗牙龈炎的中药，其特征在于，它是由以下重量配比的原料药材制备而成：牛黄0.1份、三七草5份、山竹子5份、苦竹叶5份、白头翁5份、土鳖虫6份、筋骨草4份、檀香3份、铁苋3份、芙蓉花5份、瓜蒌2份、 木通1份、大黄4份、黄柏4份、豆根4份、山楂3份、延胡索3份。
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