CN103599388B - The Chinese medicine decoction for the treatment of dysfunctional uterine bleeding - Google Patents

Abstract

The present invention relates to a kind of pharmaceutical formulation field, specifically a kind of Chinese medicine decoction for the treatment of dysfunctional uterine bleeding, it is characterized in that raw material composition is by weight percentage: Radix Scutellariae 10 ~ 13%, Herba Dendrobii 9 ~ 12%, Fructus Gardeniae Preparatus 8 ~ 11%, Fructus Ligustri Lucidi 9 ~ 11%, GUANZHONGTAN 8 ~ 11%, the Radix Astragali 5 ~ 7%, Fructus Leonuri 4 ~ 6%, Fructus Rubi 5 ~ 7%, Rhizoma Chuanxiong 6 ~ 9%, Radix Aconiti Lateralis Preparata 5 ~ 7%, Flos Carthami 4 ~ 7%, Semen Cuscutae 3 ~ 5%, Radix Rubiae 2 ~ 5%, above-mentioned 13 taste Chinese medicines are soaked in water, remove slag after decocting filtrate the present invention to treat dysfunctional uterine bleeding curative effect high, have no side effect, ovulation and anovulation phase various metrorrhagia are applicable to.

Description

The Chinese medicine decoction for the treatment of dysfunctional uterine bleeding

Technical field

The present invention relates to a kind of Chinese patent medicine preparation, specifically a kind of Chinese medicine decoction for the treatment of dysfunctional uterine bleeding.

Background technology

As everyone knows, dysfunctional uterine bleeding is called for short " anovulatory dysfunctional uterine hemorrhage ", is equivalent to " metrorrhagia " category of Chinese medicine.Refer to without systemic disease and genitals's organic disease, but what cause due to neuroendocrine system dysfunction take menoxenia as the metrorrhagia of feature.Anovulatory dysfunctional uterine hemorrhage divides anovulation type and has ovulation type.Have that ovulation type anovulatory dysfunctional uterine hemorrhage is multiple is born in Women of Childbearing Age, anovulatory functional bleeding is multiple is born in climacteric women.Its clinical manifestation is mainly the metrorrhagia of feature with menoxenia.There is ovulation type anovulatory dysfunctional uterine hemorrhage main manifestations: menstrual cycle shortens, menorrhagia, menostaxis; Anovulatory functional bleeding main manifestations: vaginal hemorrhage suddenly, amount is many or not to the utmost dripping, vexed hectic fever, feverish sensation in the palms and soles, spiritlessness and weakness etc.Clinical treatment often adopts gonadal hormone to stop blooding and adjustment menstrual cycle.A large amount of prolonged application gonadotherapy not only cost of stopping blooding is large, and easily malignant tumor occurs, and operative treatment such as endometrial resection, hysterectomy etc. not only brings great financial burden to patient simultaneously, brings great actual bodily harm to patient simultaneously.

Summary of the invention

Object of the present invention is exactly to overcome above-mentioned existing technical deficiency, a kind of Chinese medicine decoction for the treatment of dysfunctional uterine bleeding is provided, cost is low, instant effect, treatment dysfunctional uterine bleeding curative effect is high, has no side effect, there is QI and blood regulating, control collapse should ascending astringent or styptic treatment for spontaneous sweating, control the function of regulating the flow of vital energy that Lous should nourish blood, be applicable to ovulate and anovulation phase various metrorrhagia.

The technical scheme that the present invention solves the problems of the technologies described above employing is: a kind of Chinese medicine decoction for the treatment of dysfunctional uterine bleeding, it is characterized in that raw material composition is by weight percentage: Radix Scutellariae 10 ~ 13%, Herba Dendrobii 9 ~ 12%, Fructus Gardeniae Preparatus 8 ~ 11%, Fructus Ligustri Lucidi 9 ~ 11%, GUANZHONGTAN 8 ~ youngster %, the Radix Astragali 5 ~ 7%, Fructus Leonuri 4 ~ 6%, Fructus Rubi 5 ~ 7%, Rhizoma Chuanxiong 6 ~ 9%, Radix Aconiti Lateralis Preparata 5 ~ 7%, Flos Carthami 4 ~ 7%, Semen Cuscutae 3 ~ 5%, Radix Rubiae 2 ~ 5%, above-mentioned 13 taste Chinese medicines are soaked in water, filtrate of removing slag after decocting to obtain.

Beneficial effect of the present invention is that cost is low, instant effect, and treatment dysfunctional uterine bleeding curative effect is high, has no side effect, has QI and blood regulating, control collapse should ascending astringent or styptic treatment for spontaneous sweating, control the function of regulating the flow of vital energy that Lous should nourish blood, be applicable to ovulate and anovulation phase various metrorrhagia.

Detailed description of the invention

Below in conjunction with embodiment, the invention will be further described:

Embodiment 1:

First clean Radix Scutellariae 10.48, Herba Dendrobii 10.48, Fructus Gardeniae Preparatus 10.48, Fructus Ligustri Lucidi 10.48, GUANZHONGTAN 10.48, the Radix Astragali 6.3, Fructus Leonuri 6.3, Fructus Rubi 6.3, Rhizoma Chuanxiong 8.4, Radix Aconiti Lateralis Preparata 6.3, Flos Carthami 6.3, Semen Cuscutae 4.2, Radix Rubiae 3.5 is got by following component (% by weight).Often take medicine 227 grams, under greenhouse, 13 taste Chinese herbal medicine are added water to 800 ~ 1000ml, soak 3 ~ 5 hours, then boil with high heat, slow fire decocts to about 80 ~ 100 minutes, and remove slag to obtain filtrate 200ml, medicinal residues add water 300 ~ 400ml again, and decoct about 30 minutes, remove slag to obtain filtrate 100ml, be total to obtain 300ml medicinal liquid, the i.e. Chinese medicine decoction of obtained treatment dysfunctional uterine bleeding, load in sterile glass vials, envelope bottle cap is for subsequent use, every day 1 dose point 2 times is oral, each (medicine) being taken before meal 150ml.

Radix Scutellariae heat clearing and damp drying, eliminating fire and detoxication, antiabortive, cooling blood for hemostasis in of the present invention group.Blood pressure lowering, calmness, anti-microbial effect, to blood fat and blood glucose effect.Diuresis, to relieving asthma; Herba Dendrobii reinforcing stomach reg fluid, nourishing YIN and clearing away heat.Stomach promotes the production of body fluid, nourishing YIN and clearing away heat.Lose for cloudy impairment of body fluid, xerostomia excessive thirst, lack of appetite is retched, deficiency-heat after being ill, poor vision; Fructus Gardeniae Preparatus is bitter, cold.GUIXIN, lung, tri-jiao channel.Cooling blood for hemostasis.Nosebleed is told, hematuria metrorrhagia for heat in blood; Fructus Ligustri Lucidi is used for the poor vision of the hepatic and renal YIN deficiency, visual deterioration, early whitening of beard and hair, soreness of waist tinnitus and fever due to yin deficiency etc.; GUANZHONGTAN controls dysfunctional uterine hemorrhage, spits blood also effective in cure to digestive tract hemorrhage, hematuria, a small amount of; Radix Astragali invigorating QI to consolidate the body surface resistance, diuresis poison holding, evacuation of pus, expelling pus and promoting granulation.Weak for the deficiency of vital energy, anorexia and loose stool; Fructus Leonuri promoting blood flow to regulate menstruation, wind and heat dispersing.Control menoxenia, metrorrhagia leukorrhagia, postnatal blood stasis is had a pain; Liver-heat is had a headache, conjunctival congestion and swelling pain, or raw nebula film; Fructus Rubi the liver and the kidney tonifying, controlling nocturnal emission with astringent drugs reducing urination, improving eyesight cures mainly, impotence and premature ejaculation, emission and spermatorrhea, and cold womb is infertile, and leukorrhagia is rare clearly, frequent micturition incontinence of urine, and blurred vision is dark, early whitening of beard and hair; Rhizoma Chuanxiong activating QI to alleviate the depression, method wind-dryness is wet, promoting blood circulation and stopping pain.Controlling air-cooled headache revolves dizzy, and hypochondriac pain abdomen aches, arthralgia due to cold clonic spasm of the muscle, amenorrhea, difficult labour, postpartum stagnation block pain, ulcer sores.For menoxenia, amenorrhea dysmenorrhea, abdominal mass is suffered from abdominal pain, the twinge of the breast side of body, tumbling and swelling, headache, rheumatic arthralgia; Radix Aconiti Lateralis Preparata is pungent, sweet, hot greatly, poisonous.GUIXIN, kidney, spleen channel.Recuperating depleted YANG and rescuing the patient from collapse, mends fire supporing yang, dispersing cold for relieving pain.For YANG-depletion collapse, cold extremities faint pulse, deficiency of heart-YANG, obstruction of qi in the chest and cardialgia; Flos Carthami is warm in nature, acrid in the mouth, latus rectum of invigorating blood circulation, eliminating stasis to stop pain.For amenorrhea, dysmenorrhea, lochia, lump in the abdomen mass in the abdomen, traumatic injury.Be suitable for various varicosis, peripheral neuritis, blood circulation is bad, lower limb numbness or the congestion such as livid purple; Semen Cuscutae nourishing the liver and kidney, controlling nocturnal emission with astringent drugs reducing urination, antiabortive, improving eyesight, antidiarrheal.Suffer from a deficiency of the kidney rush down for impotence and seminal emission, dripping urination, enuresis frequent micturition, soreness of the waist and knees, blurred vision tinnitus, vaginal bleeding due to deficiency of the kidney during pregnancy, frequent fetal movement, spleen; Radix Rubiae nature and flavor are bitter, cold.Return Liver Channel.There is cooling blood for hemostasis, blood stasis dispelling, the effect of stimulating the menstrual flow.Cure mainly heat in blood and tell nosebleed, metrostaxis, blood stasis amenorrhea, traumatic injury, rheumatic arthralgia.The ingenious prescription of 13 taste Chinese medicine, the mutual coordinative role of medicine, to improve principal agent effect, offsets adverse drug effect, plays the specially good effect of dysfunctional uterine bleeding altogether.

The each raw material of the present invention also can the embodiment that mixes of ratio (percentage by weight) listed by according to the form below realize.Its processing technique is identical with embodiment 1.

The clinical trial carried out below in conjunction with my institute is done further the present invention, is described in detail:

1, case selection: this group 60 example, age 26-53 year, all cases is all the dysfunctional uterine bleeding that degree is different.

2, diagnostic criteria: formulate diagnostic criteria about the diagnosis basis of metrorrhagia with reference in State Administration of Traditional Chinese Medicine " Chinese medical disease Standardization of diagnosis and curative effect " [1].(1) the confusion of the menstrual cycle, does not have rule completely, and menstrual phase is different in size, and even the several months is continuous; (2) menorrhagia, or sudden and violent lower to note, or persistent vaginal bloody discharge, or both alternately occur.During serious symptom, circulatory failure in a moment; Hemorrhage in dripping shape on a small quantity, even put drop-wise hemorrhage.(3) from whole medical history, with frequent irregular bleeding, blood volume mostly is main.Therefore anemia is also common sympton, and course of disease elder can present spiritlessness and weakness, and pale complexion is nervous.(4) diagnosis is assisted in diagnostic curettage, hormone determination or other auxiliary examination.

All cases is all by above standard screening, and clinical main manifestations is: menstrual cycle, disorder of menstrual cycle, reaches above standard.Few time many time hemorrhage, off and on, or suddenly bleed profusely and continue with dripping urine endlessly, severe one with anemia in various degree and other symptom.

Exclusion standard (1) patient age is below 14 years old or more than 55 years old; (2) gestation or women breast-feeding their children; (3) allergic constitution or those who are allergic to this drug; (4) cardiovascular, liver, the serious primary disease of kidney and psychotic is associated with.(5) through the relevant inspection of medical science, with hemorrhage relevant systemic disease and reproductive system organic disease patient.

3, Therapeutic Method: often take medicine 227 grams, under greenhouse, 13 taste Chinese herbal medicine are added water to 800 ~ 1000ml, soak 3 ~ 5 hours, then boil with high heat, slow fire decocts to about 80 ~ 100 minutes, remove slag to obtain filtrate 200ml, and medicinal residues add water 300 ~ 400ml again, decoct about 30 minutes, remove slag to obtain filtrate 100ml, be total to obtain 300ml medicinal liquid, namely the Chinese medicine decoction of obtained treatment dysfunctional uterine bleeding, loads in sterile glass vials, envelope bottle cap is for subsequent use, every day 1 dose point 2 times is oral, and each (medicine) being taken before meal 150ml, treats three months altogether.

4, curative effect judging standard: the criterion of therapeutical effect of reference " new Chinese medicine treatment dysfunctional uterine bleeding guideline of clinical investigations " [2] is in conjunction with clinical treatment practical situation, formulation efficacy assessment standard is as follows: recovery from illness: after Bleeding control, continuous 3 menstrual cycle, menstrual period, blood volume are all normal, and subjective symptoms disappears; Or climacteric women blood only rear menopause person; Effective: after Bleeding control, menstrual cycle blood volume is normal, and menstrual period are longer (more than 7d, below 10d) still, and subjective symptoms disappears; Effective: menstrual cycle, menstrual period, partial symptoms are obviously improved, oligemia; Invalid: above every all without improver.

5, therapeutic effect: use compound recipe garden burnet and hairyvein agrimony soup of the present invention to treat 60 examples altogether, result recovery from illness 43, effective 9, effective 5 examples, invalid 3 examples, effective percentage is 95%, and inefficiency is 5%.

Claims (1)

1. treat the Chinese medicine decoction of dysfunctional uterine bleeding for one kind, it is characterized in that: raw material composition is by weight percentage, Radix Scutellariae 10 ~ 13%, Herba Dendrobii 9 ~ 12%, Fructus Gardeniae Preparatus 8 ~ 11%, Fructus Ligustri Lucidi 9 ~ 11%, GUANZHONGTAN 8 ~ 11%, the Radix Astragali 5 ~ 7%, Fructus Leonuri 4 ~ 6%, Fructus Rubi 5 ~ 7%, Rhizoma Chuanxiong 6 ~ 9%, Radix Aconiti Lateralis Preparata 5 ~ 7%, Flos Carthami 4 ~ 7%, Semen Cuscutae 3 ~ 5%, Radix Rubiae 2 ~ 5%, above-mentioned 13 taste Chinese medicines are soaked in water, filtrate of removing slag after decocting to obtain.