CN103598623A - Manufacturing method of sea cucumber tablets - Google Patents
Manufacturing method of sea cucumber tablets Download PDFInfo
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- CN103598623A CN103598623A CN201310492157.6A CN201310492157A CN103598623A CN 103598623 A CN103598623 A CN 103598623A CN 201310492157 A CN201310492157 A CN 201310492157A CN 103598623 A CN103598623 A CN 103598623A
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- sea cucumber
- powder
- traditional chinese
- sea
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- WPBNNNQJVZRUHP-UHFFFAOYSA-L manganese(2+);methyl n-[[2-(methoxycarbonylcarbamothioylamino)phenyl]carbamothioyl]carbamate;n-[2-(sulfidocarbothioylamino)ethyl]carbamodithioate Chemical compound [Mn+2].[S-]C(=S)NCCNC([S-])=S.COC(=O)NC(=S)NC1=CC=CC=C1NC(=S)NC(=O)OC WPBNNNQJVZRUHP-UHFFFAOYSA-L 0.000 description 1
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- QUCDWLYKDRVKMI-UHFFFAOYSA-M sodium;3,4-dimethylbenzenesulfonate Chemical compound [Na+].CC1=CC=C(S([O-])(=O)=O)C=C1C QUCDWLYKDRVKMI-UHFFFAOYSA-M 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L17/00—Food-from-the-sea products; Fish products; Fish meal; Fish-egg substitutes; Preparation or treatment thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Nutrition Science (AREA)
- Chemical & Material Sciences (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Zoology (AREA)
- Marine Sciences & Fisheries (AREA)
- Botany (AREA)
- Mycology (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention provides a manufacturing method of sea cucumber tablets, which comprises the following steps: a material preparation step, that is, preparing the following traditional Chinese medicine components, preparing high-quality sea cucumbers, preparing additives of chitin, starch, dextrin, mannitol, a sweetener, and microcrystalline cellulose; A. a cleaning step, that is, cleaning madder, parsnip, ligusticum wallichii, achyranthes roots, rosa chinensis, radix astragali, dandelion, garden burnet, anemarrhena, honeysuckle flowers, radix scrophulariae, rheum officinale, large-leaved gentian, and cinnamon by a drum-type herbal medicine washing machine; B. a herbal medicine infiltrating step; C. preparation of the above components into traditional Chinese medicine powder; D. a sea cucumber deep processing step to obtain a sea cucumber extract; E. a capsule preparation step, that is, adding the traditional Chinese medicine powder obtained in step C into the sea cucumber extract obtained in step D according to a weight ratio of the traditional Chinese medicine powder to the sea cucumber extract of 1-1.3:1-1.8; well mixing, adding the additives to obtain a pasty mixture, tabletting, and drying to obtain the chewing tablets. The manufacturing method of the invention is simple; the prepared product is simple in composition, and reasonable in formula combination, and can promote immune regulation and increase wound healing speed.
Description
technical field:
The present invention relates to sea cucumber deep process technology field, relate in particular to a kind of manufacture method of sea cucumber tablet.
background technology:
Sea cucumber is extremely low containing cholesterol, is a kind of typical high protein, low fat, low cholesterol food.Add its fine and tender taste, be easy to digestion, so, be suitable for very much the elderly, children and the people that has a delicate constitution edible.Sea cucumber, because of extremely low containing cholesterol, is the food of a kind of typical high protein, low fat, low cholesterol.Because of fine and tender taste, be easy to digestion again, thus be applicable to very much the elderly and children, and the person of having a delicate constitution is edible.Taurine in sea cucumber, niacin etc.; there is the nervous system of adjusting, elimination fatigue fast; the effect of prevention skin aging; the taurine containing in sea cucumber in addition, lysine, methionine etc. almost do not have in vegetable food; the chondroitin sulfate containing in stichopus japonicus and stichopus japonicus mucopolysaccharide; by pharmacological evaluation, prove, to the growing of human body, anti-inflammatory skeletonization and prevention failure, promoting wound healing to suppress several cancer cells has special efficacy.Continuity is old and feeble, eliminate tired, improve immunity, the ability sea cucumber that strengthens resist the disease is rich in the natural precious active materials of kind more than 50 such as protein, mineral matter, vitamin, wherein acid mucopolysaccharide and chondroitin can obviously reduce the quantity of lipofuscin and skin proline in heart tissue, play the effect delaying senility.In sea cucumber body, 18 contained seed amino acids can strengthen the metabolic function of tissue, and enhanced machine body cell vigor, is suitable for the teenager in growing.Sea cucumber energy balance the body water balance, is suitable for the Ms of pregnancy period legs and feet edema.Sea cucumber can be eliminated tired, improves body immunity, strengthens the ability of human body resist the disease, is therefore applicable to very much often middle aged Ms and the man in fatigue state, the sub-health populations such as easy catching a cold, the elderly who has a delicate constitution and children.
Other functions of sea cucumber, as eliminated tumour, the anticancer heart that protects: contain a large amount of holothurins in the tissues such as body wall, internal organ and body of gland of sea cucumber, be again Sea Cucumber Glycosides.Holothurin is a kind of counterpoison, nontoxic to human-body safety, but growth and the transfer of energy inhibition tumor cell, effectively anti-cancer, anticancer, has been widely used in the treatment of liver cancer, lung cancer, cancer of the stomach, nasopharyngeal carcinoma, osteocarcinoma, lymph cancer, oophoroma, the cancer of the uterus, breast cancer, cancer of the brain leukaemia and hand postoperative patient clinically.Improve the frequent beche-de-mer of osteoporosis and can prevent children's rickets, adult's osteoporosis and hyperostosis.In gold most distinguished sea cucumber, the element such as abundant calcium, phosphorus, manganese, copper, germanium, silicon is to prevention Infant Rickets, adult's osteoporosis and to skeletal abnormality, deformity, and dentine and enamel development be bad special role.Enhancing development beche-de-mer helps lend some impetus to and grows.Abundant arginine, lysine, taurine, calcium, phosphorus, iodine, iron, zinc in sea cucumber; it is the important substance that human development grows up; they participate in the physiological activities such as the growing of human body itself, immune regulation, wound healing, reproductive development directly; in body energy deposit and running, play an important role; therefore; as postoperative nutriment, sea cucumber can be accelerated the healing rate of wound greatly.
In daily life and medical treatment, wound can hardly be avoided, as wound, operation etc. all can cause certain wound.Due to the situation of wound healing and the development of the state of an illness closely related, therefore wound healing becomes one of focus important in medical research now.In recent years, Chinese herbal medicine is subject to people's favor gradually, and traditional Chinese medicine is just in healthy and strong development, and the research of Chinese herbal medicine supporting wound healing also continues to bring out.Now just to Chinese herbal medicine, promote the effects anb Mechanism of wound healing to be summarized as follows.The traditional Chinese medical science is wanted > > to note to the understanding < < roman class of wound healing to say: " limbs damage in outside, qi and blood is hindered in interior, battalion defends to some extent does not pass through, internal organs by discord." point out after body wound qi and blood lose support, battalion defending to become estranged and causing that qi and blood stagnation, channels and collaterals block, visceral dysfunction.The qi and blood prosperity and decline of the surface of a wound, battalion defend strong and weak most important to the healing of the surface of a wound, therefore promoting blood circulation and removing blood stasis, promoting qi circulation and removing obstruction in the collateral is the key for the treatment of wound.Traditional Chinese medicine thinks, wound is caused by external cause, and " wound " is more shallow at skin surface, degree, and " wound " refers to the infringement that metal sharp sword causes, the deep muscle that reaches.No matter which kind of wound, all can injure blood network, vascular, occurs hemorrhage, hemostasis or hemotoncus, and stopping blooding, subsiding a swelling, invigorate blood circulation is the requisite step for the treatment of wound.Traditional Chinese medicine promotes the growth of surface of a wound granulation tissue mainly to concentrate on the aspects such as putrefaction-removing granulation-promoting, expelling the stasis for the new and help myogenic.
Sea cucumber has remarkable result for promotion wound healing, so, usually used as the nutritional supplement after postoperative or wound.The instructions of taking of sea cucumber, still take tonic as main at present, and tonic causes human absorptivity not enough, and the taboo of some culinary arts also usually causes the loss of sea cucumber nutrient composition, as, sea cucumber can not be cooked flavouring with vinegar.Therefore, there are on the market some sea cucumber deep processed products, as oral liquid, tablet, capsule, honey refining pill etc., in the process of deep processing, often adds Chinese patent drug to improve the absorptivity of product or to increase other auxiliary functions, but, some formula is unreasonable, for example, sea cucumber can not with Radix Glycyrrhizae compatibility etc.Therefore, it is simple that the present invention aims to provide a kind of manufacture method, and the product proportioning making is simple, and rationally, the manufacture method of a kind of sea cucumber tablet of speed of wound healing is reconciled, increased to Promote immunity in prescription collocation.
summary of the invention:
The object of the invention is to overcome the shortcoming existing in prior art, provide a kind of manufacture method simple, the product proportioning making is simple, and rationally, the manufacture method of a kind of sea cucumber tablet of speed of wound healing is reconciled, increased to Promote immunity in prescription collocation.
To achieve these goals, the invention provides a kind of manufacture method of sea cucumber tablet, wherein, comprise the steps:
The step of getting the raw materials ready:
Alternative following traditional Chinese medicinal components, alternative high-quality sea cucumber, alternative additional material: chitin, starch, dextrin, sweet mellow wine, sweetener, microcrystalline cellulose.
The step of A, cleaning: by madder, pig label grass, Ligusticum wallichii, the root of bidentate achyranthes, China rose, the Radix Astragali, dandelion, garden burnet, the wind-weed, honeysuckle, radix scrophulariae, rheum officinale, Qin Jiu, Chinese cassia tree, is used tumbling-box type medicine-washing machine to clean, and scavenging period is controlled at 5-10 minute, avoids drug effect to run off;
The step of B, demulcen: the traditional Chinese medicinal components that steps A is cleaned up, use water injection type medicine processing device to carry out demulcen operation, demulcen makes the plant cell imbibition of dehydration, and demulcen time 2-3 disappears, for abstraction process creates conditions;
C, above-mentioned component add 12 times of weight amount ethanol, heating and refluxing extraction 3 times, and each 2 hours, No. 3 extracts are merged, decompression recycling ethanol, and to be concentrated into liquor strength be 0.5g crude drug/mL, after suction filtration, when the relative density of filtrate is 20 ℃ 1.2; The large pore resin absorption column that described filtrate flow is 10L through volume, use afterwards deionized water or the distilled water wash-out of 10 times of resin column volumes, use again 95% ethanol elution of 5 times of resin column volumes, collect ethanol eluate, remove alcohol solvent, obtain Chinese medicinal powder, then after 80 order sieve, standby after ultraviolet sterilization;
The step of D, sea cucumber deep processing: fresh and alive sea cucumbers, along belly from first to last complete section open, gill, impurity is cleaned up; Then carry out freeze drying, cryogenic temperature is-20 ~-25 ℃, and vacuum is 5-15Pa, and snap frozen 2-3h puts into pulverizer by the sea cucumber after freeze drying, pulverizes 10-30min, crosses 60 mesh sieves, obtains thick sea cucumber powder; Sea cucumber meal is carried out to ultramicro grinding by airslide disintegrating mill, and time 2-3h, obtains ultra micro sea cucumber powder; Then ultra micro sea cucumber powder is carried out to nanometer pulverizing by high speed shear ultrafine crusher, grinding time is 3-5h;
In container, add pure water, sea cucumber powder after nanometer is pulverized with water with 1: the dissolving of 5-10 mass ratio, obtain sea cucumber milk, take the compound protease of sea cucumber weight 0.3-0.4%, compound protease is the mixture of pepsic bromelain stomach, protease: the mass ratio=2:1 of bromelain, after using pure water that compound protease is dissolved, together with sea cucumber milk, put into enzymatic vessel, standing 1-2min in the microwave environment that is 500-1000w in intensity, carry out the operation of microwave enzymolysis, after enzymolysis completes, by enzymolysis liquid rapidly degree of intensification to 90 ℃ of enzyme 10-30min that go out, complete after the deactivation of enzyme, enzymatic vessel is stopped to heating, enzymolysis liquid is cooled to rapidly to normal temperature, enzymatic vessel purified rinse water, flushing liquor is put into enzymolysis liquid, enzymolysis liquid after cooling is first used to the centrifugal 20min of generic centrifuge, filter, get filtrate, the centrifugal 20min of low temperature ultrahigh speed, filters, and obtains filtrate, by filtrate by nanofiltration with except freshen, residue is crossed 80 mesh sieves, obtains sea cucumber extract,
E, prepare the step of capsule: step C gained Chinese medicinal powder is joined in the sea cucumber extract of step D gained to Chinese medicinal powder: the weight ratio of sea cucumber extract is 1-1.3:1-1.8; After mixing, add additional material, in the pasty state, compression molding, is dried to obtain chewable tablets to the mixture obtaining.
When prepared by the present invention, select the active component of following parts by weight:
Middle spice: madder 30-50 part, pig label grass 20-40 part, Ligusticum wallichii 20-40 part, root of bidentate achyranthes 20-40 part, China rose 10-30 part, Radix Astragali 10-30 part, dandelion 10-30 part, garden burnet 10-30 part, wind-weed 10-30 part, honeysuckle 10-30 part, radix scrophulariae 10-30 part, rheum officinale 10-30 Fen， Qin Jiu 10-30 part, Chinese cassia tree 10-30 part
Basestocks: sea cucumber 300-500 part;
Additional material: chitin 3-6 part, starch 10-20 part, dextrin 5-10 part, sweet mellow wine 3-6 part, sweetener 1-4 part, microcrystalline cellulose 1-4 part.
Or, comprise according to the following active component of parts by weight configuration:
Middle spice: madder 30-40 part, pig label grass 20-30 part, Ligusticum wallichii 20-30 part, root of bidentate achyranthes 20-30 part, China rose 10-20 part, Radix Astragali 10-20 part, dandelion 10-20 part, garden burnet 10-20 part, wind-weed 10-20 part, honeysuckle 10-20 part, radix scrophulariae 10-20 part, rheum officinale 10-20 Fen， Qin Jiu 10-20 part, Chinese cassia tree 10-20 part
Basestocks: sea cucumber 300-400 part;
Additional material: chitin 3-5 part, starch 10-15 part, dextrin 5-8 part, sweet mellow wine 3-5 part, sweetener 1-3 part, microcrystalline cellulose 1-3 part.
Or, comprise according to the following active component of parts by weight configuration:
Middle spice: madder 40-50 part, pig label grass 30-40 part, Ligusticum wallichii 30-40 part, root of bidentate achyranthes 30-40 part, China rose 20-30 part, Radix Astragali 20-30 part, dandelion 20-30 part, garden burnet 20-30 part, wind-weed 20-30 part, honeysuckle 20-30 part, radix scrophulariae 20-30 part, rheum officinale 20-30 Fen， Qin Jiu 20-30 part, Chinese cassia tree 20-30 part
Basestocks: sea cucumber 400-500 part;
Additional material: chitin 4-6 part, starch 15-20 part, dextrin 8-10 part, sweet mellow wine 4-6 part, sweetener 2-4 part, microcrystalline cellulose 2-4 part.
Or, comprise according to the following active component of parts by weight configuration:
Middle spice: middle spice: madder 35-45 part, pig label grass 25-35 part, Ligusticum wallichii 25-35 part, root of bidentate achyranthes 25-35 part, China rose 15-25 part, Radix Astragali 15-25 part, dandelion 15-25 part, garden burnet 15-25 part, wind-weed 15-25 part, honeysuckle 15-25 part, radix scrophulariae 15-25 part, rheum officinale 15-25 Fen， Qin Jiu 15-25 part, Chinese cassia tree 15-25 part
Basestocks: sea cucumber 350-450 part;
Additional material: chitin 4-5 part, starch 12-18 part, dextrin 6-9 part, sweet mellow wine 2-5 part, sweetener 2-3 part, microcrystalline cellulose 2-3 part.
Composition in additional material is as follows:
The medical knowledge effect of chitin (being chitin) is as follows: 1, trauma hemostasis, the chitin of blood platelet in blood is combined, and can improve the adhesion of wound tissue, makes fast local vascular shrink, and reduces hemorrhage quantity.2, improve speed of wound healing, the basic substance of volume is badly in need of in new histiocytic propagation, formation, and hyaluronic acid is important material.Crust mass-energy increases hyaluronic quantity in tissue, promotes the formation of cell membrane.And in activating cell process, produce a large amount of collagenous fibres, and form rapidly compact substance skin, can scar.3, chitin can be prevented and treated wound face and infects, and chitin is used in wound part outward can bacteria growing inhibiting, and domestic and foreign literature report chitin applies wound in vitro can suppress gram-positive bacteria and candida albicans growth, and 5 mg/ml bacteriostasis rates reach 75 ~ 100%; Can increase the local cytophagous quantity of wound and activity; Eliminate in time slough, promote the formation of granulation tissue.This three large key element that forms wound wound healing, complements each other and comprehensively works.4, the application of chitin on Orthopeadic Surgery, chitin is as the damaged portion of bone filler, owing to helping platelet adhesion reaction to accelerate aggegation, show good anastalsis, at chitinous phagocyte, the macrophage of assembling volume around, the invasion and attack that suppress local pathogen have the effect that obvious accelerated bone is repaired.
Starch: relatively more conventional is cornstarch, its character is highly stable, inoperative with most drug, price is also more cheap, and hygroscopicity is little, appearance luster good, in actual production, often mix use with the good Icing Sugar of compressibility, dextrin, this is because the compressibility of starch is poor, if use separately, can make the tablet of extrusion too loose.
Dextrin: dextrin is the general name of Starch Hydrolysis intermediate product, its chemical formula is (C6H10O5) nXH2O, its hydrotrope is about 80%, dissolves slowlyer in cold water, is soluble in hot water, is insoluble to ethanol.Also be called traditionally as height and stick with paste (high viscosity dextrin), there is stronger caking property.
Microcrystalline cellulose: microcrystalline cellulose (Microcrystalline cellulose, MCC) be cellulose partial hydrolysis and the less crystallinity cellulose of the degree of polymerization that makes, there is good compressibility, there is stronger adhesion, the tablet being pressed into has more greatly hardness, and " dry adhesives " that can be used as direct powder compression used.
Sweet mellow wine: sweet mellow wine is particle or Powdered, heat absorption when orally-dissolvable, thereby have cooling feeling, and have certain sweet taste concurrently simultaneously, in mouth, without sand type, therefore be suitable for preparing chewable tablets.
Sweetener (preferably Icing Sugar): Icing Sugar means the white powder that crystallinity sucrose forms after low temperature drying is pulverized, and its advantage is that bonding force is strong, can be used to increase the hardness of tablet, and makes the smooth surface of tablet attractive in appearance.
Advantage of the present invention is: manufacture method is simple, and the product proportioning making is simple, and rationally, Promote immunity is reconciled, increased speed of wound healing, is specially in prescription collocation:
The present invention be take sea cucumber as basestocks, add therein promoting blood circulation and removing blood stasis, hemostasis and pain-relieving, promoting qi circulation and removing obstruction in the collateral, the corresponding traditional Chinese medicinal components of clearing heat and moistening dryness, to improve speed of wound healing, in addition, further add chitin, sea cucumber effect, herbal function are combined with chitin effect, preparation becomes chewable tablets to be used, and all effect is remarkable in the speed for the treatment of wound for more independent treatment by Chinese herbs, simple sea cucumber tonic or chitin capsule and pill.
the specific embodiment:
The step of getting the raw materials ready:
Alternative following traditional Chinese medicinal components, alternative high-quality sea cucumber, alternative additional material: chitin, starch, dextrin, sweet mellow wine, sweetener, microcrystalline cellulose.
The step of A, cleaning: by madder, pig label grass, Ligusticum wallichii, the root of bidentate achyranthes, China rose, the Radix Astragali, dandelion, garden burnet, the wind-weed, honeysuckle, radix scrophulariae, rheum officinale, Qin Jiu, Chinese cassia tree, is used tumbling-box type medicine-washing machine to clean, and scavenging period is controlled at 5-10 minute, avoids drug effect to run off;
The step of B, demulcen: the traditional Chinese medicinal components that steps A is cleaned up, use water injection type medicine processing device to carry out demulcen operation, demulcen makes the plant cell imbibition of dehydration, and demulcen time 2-3 disappears, for abstraction process creates conditions;
C, above-mentioned component add 12 times of weight amount ethanol, heating and refluxing extraction 3 times, and each 2 hours, No. 3 extracts are merged, decompression recycling ethanol, and to be concentrated into liquor strength be 0.5g crude drug/mL, after suction filtration, when the relative density of filtrate is 20 ℃ 1.2; The large pore resin absorption column that described filtrate flow is 10L through volume, use afterwards deionized water or the distilled water wash-out of 10 times of resin column volumes, use again 95% ethanol elution of 5 times of resin column volumes, collect ethanol eluate, remove alcohol solvent, obtain Chinese medicinal powder, then after 80 order sieve, standby after ultraviolet sterilization;
The step of D, sea cucumber deep processing: fresh and alive sea cucumbers, along belly from first to last complete section open, gill, impurity is cleaned up; Then carry out freeze drying, cryogenic temperature is-20 ~-25 ℃, and vacuum is 5-15Pa, and snap frozen 2-3h puts into pulverizer by the sea cucumber after freeze drying, pulverizes 10-30min, crosses 60 mesh sieves, obtains thick sea cucumber powder; Sea cucumber meal is carried out to ultramicro grinding by airslide disintegrating mill, and time 2-3h, obtains ultra micro sea cucumber powder; Then ultra micro sea cucumber powder is carried out to nanometer pulverizing by high speed shear ultrafine crusher, grinding time is 3-5h;
In container, add pure water, sea cucumber powder after nanometer is pulverized with water with 1: the dissolving of 5-10 mass ratio, obtain sea cucumber milk, take the compound protease of sea cucumber weight 0.3-0.4%, compound protease is the mixture of pepsic bromelain stomach, protease: the mass ratio=2:1 of bromelain, after using pure water that compound protease is dissolved, together with sea cucumber milk, put into enzymatic vessel, standing 1-2min in the microwave environment that is 500-1000w in intensity, carry out the operation of microwave enzymolysis, after enzymolysis completes, by enzymolysis liquid rapidly degree of intensification to 90 ℃ of enzyme 10-30min that go out, complete after the deactivation of enzyme, enzymatic vessel is stopped to heating, enzymolysis liquid is cooled to rapidly to normal temperature, enzymatic vessel purified rinse water, flushing liquor is put into enzymolysis liquid, enzymolysis liquid after cooling is first used to the centrifugal 20min of generic centrifuge, filter, get filtrate, the centrifugal 20min of low temperature ultrahigh speed, filters, and obtains filtrate, by filtrate by nanofiltration with except freshen, residue is crossed 80 mesh sieves, obtains sea cucumber extract,
E, prepare the step of capsule: step C gained Chinese medicinal powder is joined in the sea cucumber extract of step D gained to Chinese medicinal powder: the weight ratio of sea cucumber extract is 1-1.3:1-1.8; After mixing, add additional material, in the pasty state, compression molding, is dried to obtain chewable tablets to the mixture obtaining.
Object lesson 1
Middle spice: 50 parts, madder, 40 parts of pig label grass, 40 parts of Ligusticum wallichiis, 40 parts of the roots of bidentate achyranthes, 30 parts of China roses, 30 parts of the Radixs Astragali, 30 parts of dandelions, 30 parts of garden burnets, 30 parts of the wind-weeds, 30 parts of honeysuckles, 30 parts of radix scrophulariaes, 30 parts of rheum officinale 30Fen， Qin Jiu, 30 parts of Chinese cassia trees,
Basestocks: 500 parts of sea cucumbers;
Additional material: 6 parts of chitins, 20 parts of starch, 10 parts, dextrin, 6 parts, sweet mellow wine, 4 parts of sweeteners, 4 parts of microcrystalline celluloses.
During preparation, the step of getting the raw materials ready:
Alternative following traditional Chinese medicinal components, alternative high-quality sea cucumber, alternative additional material: chitin, starch, dextrin, sweet mellow wine, sweetener, microcrystalline cellulose.
The step of A, cleaning: by madder, pig label grass, Ligusticum wallichii, the root of bidentate achyranthes, China rose, the Radix Astragali, dandelion, garden burnet, the wind-weed, honeysuckle, radix scrophulariae, rheum officinale, Qin Jiu, Chinese cassia tree, is used tumbling-box type medicine-washing machine to clean, and scavenging period is controlled at 5-10 minute, avoids drug effect to run off;
The step of B, demulcen: the traditional Chinese medicinal components that steps A is cleaned up, use water injection type medicine processing device to carry out demulcen operation, demulcen makes the plant cell imbibition of dehydration, and demulcen time 2-3 disappears, for abstraction process creates conditions;
C, above-mentioned component add 12 times of weight amount ethanol, heating and refluxing extraction 3 times, and each 2 hours, No. 3 extracts are merged, decompression recycling ethanol, and to be concentrated into liquor strength be 0.5g crude drug/mL, after suction filtration, when the relative density of filtrate is 20 ℃ 1.2; The large pore resin absorption column that described filtrate flow is 10L through volume, use afterwards deionized water or the distilled water wash-out of 10 times of resin column volumes, use again 95% ethanol elution of 5 times of resin column volumes, collect ethanol eluate, remove alcohol solvent, obtain Chinese medicinal powder, then after 80 order sieve, standby after ultraviolet sterilization;
The step of D, sea cucumber deep processing: fresh and alive sea cucumbers, along belly from first to last complete section open, gill, impurity is cleaned up; Then carry out freeze drying, cryogenic temperature is-20 ~-25 ℃, and vacuum is 5-15Pa, and snap frozen 2-3h puts into pulverizer by the sea cucumber after freeze drying, pulverizes 10-30min, crosses 60 mesh sieves, obtains thick sea cucumber powder; Sea cucumber meal is carried out to ultramicro grinding by airslide disintegrating mill, and time 2-3h, obtains ultra micro sea cucumber powder; Then ultra micro sea cucumber powder is carried out to nanometer pulverizing by high speed shear ultrafine crusher, grinding time is 3-5h;
In container, add pure water, sea cucumber powder after nanometer is pulverized with water with 1: the dissolving of 5-10 mass ratio, obtain sea cucumber milk, take the compound protease of sea cucumber weight 0.3-0.4%, compound protease is the mixture of pepsic bromelain stomach, protease: the mass ratio=2:1 of bromelain, after using pure water that compound protease is dissolved, together with sea cucumber milk, put into enzymatic vessel, standing 1-2min in the microwave environment that is 500-1000w in intensity, carry out the operation of microwave enzymolysis, after enzymolysis completes, by enzymolysis liquid rapidly degree of intensification to 90 ℃ of enzyme 10-30min that go out, complete after the deactivation of enzyme, enzymatic vessel is stopped to heating, enzymolysis liquid is cooled to rapidly to normal temperature, enzymatic vessel purified rinse water, flushing liquor is put into enzymolysis liquid, enzymolysis liquid after cooling is first used to the centrifugal 20min of generic centrifuge, filter, get filtrate, the centrifugal 20min of low temperature ultrahigh speed, filters, and obtains filtrate, by filtrate by nanofiltration with except freshen, residue is crossed 80 mesh sieves, obtains sea cucumber extract,
E, prepare the step of capsule: step C gained Chinese medicinal powder is joined in the sea cucumber extract of step D gained to Chinese medicinal powder: the weight ratio of sea cucumber extract is 1-1.3:1-1.8; After mixing, add additional material, in the pasty state, compression molding, is dried to obtain chewable tablets to the mixture obtaining.
Object lesson 2
Middle spice: 30 parts, madder, 20 parts of pig label grass, 20 parts of Ligusticum wallichiis, 20 parts of the roots of bidentate achyranthes, 10 parts of China roses, 10 parts of the Radixs Astragali, 10 parts of dandelions, 10 parts of garden burnets, 10 parts of the wind-weeds, 10 parts of honeysuckles, 10 parts of radix scrophulariaes, 10 parts of rheum officinale 10Fen， Qin Jiu, 10 parts of Chinese cassia trees,
Basestocks: 300 parts of sea cucumbers;
Additional material: 3 parts of chitins, 10 parts of starch, 5 parts, dextrin, 3 parts, sweet mellow wine, 1 part of sweetener, 1 part of microcrystalline cellulose.
During preparation, the step of getting the raw materials ready:
Alternative following traditional Chinese medicinal components, alternative high-quality sea cucumber, alternative additional material: chitin, starch, dextrin, sweet mellow wine, sweetener, microcrystalline cellulose.
The step of A, cleaning: by madder, pig label grass, Ligusticum wallichii, the root of bidentate achyranthes, China rose, the Radix Astragali, dandelion, garden burnet, the wind-weed, honeysuckle, radix scrophulariae, rheum officinale, Qin Jiu, Chinese cassia tree, is used tumbling-box type medicine-washing machine to clean, and scavenging period is controlled at 5-10 minute, avoids drug effect to run off;
The step of B, demulcen: the traditional Chinese medicinal components that steps A is cleaned up, use water injection type medicine processing device to carry out demulcen operation, demulcen makes the plant cell imbibition of dehydration, and demulcen time 2-3 disappears, for abstraction process creates conditions;
C, above-mentioned component add 12 times of weight amount ethanol, heating and refluxing extraction 3 times, and each 2 hours, No. 3 extracts are merged, decompression recycling ethanol, and to be concentrated into liquor strength be 0.5g crude drug/mL, after suction filtration, when the relative density of filtrate is 20 ℃ 1.2; The large pore resin absorption column that described filtrate flow is 10L through volume, use afterwards deionized water or the distilled water wash-out of 10 times of resin column volumes, use again 95% ethanol elution of 5 times of resin column volumes, collect ethanol eluate, remove alcohol solvent, obtain Chinese medicinal powder, then after 80 order sieve, standby after ultraviolet sterilization;
The step of D, sea cucumber deep processing: fresh and alive sea cucumbers, along belly from first to last complete section open, gill, impurity is cleaned up; Then carry out freeze drying, cryogenic temperature is-20 ~-25 ℃, and vacuum is 5-15Pa, and snap frozen 2-3h puts into pulverizer by the sea cucumber after freeze drying, pulverizes 10-30min, crosses 60 mesh sieves, obtains thick sea cucumber powder; Sea cucumber meal is carried out to ultramicro grinding by airslide disintegrating mill, and time 2-3h, obtains ultra micro sea cucumber powder; Then ultra micro sea cucumber powder is carried out to nanometer pulverizing by high speed shear ultrafine crusher, grinding time is 3-5h;
In container, add pure water, sea cucumber powder after nanometer is pulverized with water with 1: the dissolving of 5-10 mass ratio, obtain sea cucumber milk, take the compound protease of sea cucumber weight 0.3-0.4%, compound protease is the mixture of pepsic bromelain stomach, protease: the mass ratio=2:1 of bromelain, after using pure water that compound protease is dissolved, together with sea cucumber milk, put into enzymatic vessel, standing 1-2min in the microwave environment that is 500-1000w in intensity, carry out the operation of microwave enzymolysis, after enzymolysis completes, by enzymolysis liquid rapidly degree of intensification to 90 ℃ of enzyme 10-30min that go out, complete after the deactivation of enzyme, enzymatic vessel is stopped to heating, enzymolysis liquid is cooled to rapidly to normal temperature, enzymatic vessel purified rinse water, flushing liquor is put into enzymolysis liquid, enzymolysis liquid after cooling is first used to the centrifugal 20min of generic centrifuge, filter, get filtrate, the centrifugal 20min of low temperature ultrahigh speed, filters, and obtains filtrate, by filtrate by nanofiltration with except freshen, residue is crossed 80 mesh sieves, obtains sea cucumber extract,
E, prepare the step of capsule: step C gained Chinese medicinal powder is joined in the sea cucumber extract of step D gained to Chinese medicinal powder: the weight ratio of sea cucumber extract is 1-1.3:1-1.8; After mixing, add additional material, in the pasty state, compression molding, is dried to obtain chewable tablets to the mixture obtaining.
Object lesson 3
Middle spice: 40 parts, madder, 30 parts of pig label grass, 30 parts of Ligusticum wallichiis, 30 parts of the roots of bidentate achyranthes, 20 parts of China roses, 20 parts of the Radixs Astragali, 20 parts of dandelions, 20 parts of garden burnets, 20 parts of the wind-weeds, 20 parts of honeysuckles, 20 parts of radix scrophulariaes, 20 parts of rheum officinale 20Fen， Qin Jiu, 20 parts of Chinese cassia trees,
Basestocks: 400 parts of sea cucumbers;
Additional material: 5 parts of chitins, 15 parts of starch, 8 parts, dextrin, 5 parts, sweet mellow wine, 3 parts of sweeteners, 3 parts of microcrystalline celluloses.
During preparation, the step of getting the raw materials ready:
Alternative following traditional Chinese medicinal components, alternative high-quality sea cucumber, alternative additional material: chitin, starch, dextrin, sweet mellow wine, sweetener, microcrystalline cellulose.
The step of A, cleaning: by madder, pig label grass, Ligusticum wallichii, the root of bidentate achyranthes, China rose, the Radix Astragali, dandelion, garden burnet, the wind-weed, honeysuckle, radix scrophulariae, rheum officinale, Qin Jiu, Chinese cassia tree, is used tumbling-box type medicine-washing machine to clean, and scavenging period is controlled at 5-10 minute, avoids drug effect to run off;
The step of B, demulcen: the traditional Chinese medicinal components that steps A is cleaned up, use water injection type medicine processing device to carry out demulcen operation, demulcen makes the plant cell imbibition of dehydration, and demulcen time 2-3 disappears, for abstraction process creates conditions;
C, above-mentioned component add 12 times of weight amount ethanol, heating and refluxing extraction 3 times, and each 2 hours, No. 3 extracts are merged, decompression recycling ethanol, and to be concentrated into liquor strength be 0.5g crude drug/mL, after suction filtration, when the relative density of filtrate is 20 ℃ 1.2; The large pore resin absorption column that described filtrate flow is 10L through volume, use afterwards deionized water or the distilled water wash-out of 10 times of resin column volumes, use again 95% ethanol elution of 5 times of resin column volumes, collect ethanol eluate, remove alcohol solvent, obtain Chinese medicinal powder, then after 80 order sieve, standby after ultraviolet sterilization;
The step of D, sea cucumber deep processing: fresh and alive sea cucumbers, along belly from first to last complete section open, gill, impurity is cleaned up; Then carry out freeze drying, cryogenic temperature is-20 ~-25 ℃, and vacuum is 5-15Pa, and snap frozen 2-3h puts into pulverizer by the sea cucumber after freeze drying, pulverizes 10-30min, crosses 60 mesh sieves, obtains thick sea cucumber powder; Sea cucumber meal is carried out to ultramicro grinding by airslide disintegrating mill, and time 2-3h, obtains ultra micro sea cucumber powder; Then ultra micro sea cucumber powder is carried out to nanometer pulverizing by high speed shear ultrafine crusher, grinding time is 3-5h;
In container, add pure water, sea cucumber powder after nanometer is pulverized with water with 1: the dissolving of 5-10 mass ratio, obtain sea cucumber milk, take the compound protease of sea cucumber weight 0.3-0.4%, compound protease is the mixture of pepsic bromelain stomach, protease: the mass ratio=2:1 of bromelain, after using pure water that compound protease is dissolved, together with sea cucumber milk, put into enzymatic vessel, standing 1-2min in the microwave environment that is 500-1000w in intensity, carry out the operation of microwave enzymolysis, after enzymolysis completes, by enzymolysis liquid rapidly degree of intensification to 90 ℃ of enzyme 10-30min that go out, complete after the deactivation of enzyme, enzymatic vessel is stopped to heating, enzymolysis liquid is cooled to rapidly to normal temperature, enzymatic vessel purified rinse water, flushing liquor is put into enzymolysis liquid, enzymolysis liquid after cooling is first used to the centrifugal 20min of generic centrifuge, filter, get filtrate, the centrifugal 20min of low temperature ultrahigh speed, filters, and obtains filtrate, by filtrate by nanofiltration with except freshen, residue is crossed 80 mesh sieves, obtains sea cucumber extract,
E, prepare the step of capsule: step C gained Chinese medicinal powder is joined in the sea cucumber extract of step D gained to Chinese medicinal powder: the weight ratio of sea cucumber extract is 1-1.3:1-1.8; After mixing, add additional material, in the pasty state, compression molding, is dried to obtain chewable tablets to the mixture obtaining.
eating effect comparison of the present invention:
50 small white mouses of take are animal used as test, by the long 3mm of rear thigh incised wound of 50 small white mouses, the wound of dark 1mm, respectively smear mercurochrome and wrap gauze, and then every 10 is one group,
First group is the present invention of experimental group feeding,
Second group as a control group 1, do not feed.
The 3rd group as a control group 2, feeding step C gained Chinese medicinal powder.
The 3rd group as a control group 3, feeding contains chitinous capsule and pill.
The 4th group as a control group 4, the sea cucumber extract of feeding step D gained.
The 5th group as a control group 5, direct feeding sea cucumber.
After 3 weeks, wound is carried out to gross specimen observation, biomethanics test, gross specimen observed result: experimental group wound heals completely, falls scab naturally;
Control group 1, not healing.Heal completely compared with 12 days experimental group evenings
Control group 2, healing, does not fall scab substantially; Heal completely compared with 5 days experimental group evenings
Control group 3, healing, does not fall scab substantially; Heal completely compared with 7 days experimental group evenings
To group, according to 4, healing, does not fall scab substantially; Heal completely compared with 6 days experimental group evenings
Control group 5, healing, healed completely compared with 10 days experimental group evenings
Biomethanics test result is as following table:
As can be seen from the above table, the present invention has the effect of quickly-healing wound.
immunity comparison:
Select 10 small white mouse feeding tradition sea cucumber tablets as a control group,
Select 10 small white mouse feedings the present invention group as a comparison.
Be compared as follows:
Wherein, the absorption of comparative group calcium and mineral matter is fast, and propagation Bifidobacterium, lactic acid bacteria number is many, and the index of blood fat, blood sugar, adjusting cholesterol is low compared with control group.3-5 is placed in dark environment and the environment that is exposed to the sun repeatedly in day, the control group probability of catching an illness is large, so comparative group immunity is strong.
In the present invention, Chinese medicine composition is for the pharmacy mechanism evidence that promotes wound healing:
1, lower the expression of HIF-1 alpha levels, rise VEGF, histocyte can be induced and be produced HIF-1 (hypoxia-inducible factor-1 under hypoxic-ischemic environment, HIF-1, comprise two kinds of HIF-1 α and HIF-1 β), wherein HIF-1 α can modulating vascular endothelial growth factors (vascular endothelial growth factor, VEGF), the expression of endothelin-1, hematopoietin etc., promote formation and the vascular remodeling of new vessels, thereby start wound repair mechanism.By observing benefiting qi and removing blood stasis Chinese medicine, promote the impact of diabetes skin ulcer Rats Exposed To Hypoxia inducible factor-1 and vascular endothelial growth factor, result shows that benefiting qi and removing blood stasis Chinese medicine can be by lowering the expression of HIF-1 α, the expression of rise VEGF, improve ischaemic anaerobic condition, impel angiogenesis, thus wound healing.
2, the acceptor RTK activity in enhancing wound healing is in the process of wound healing, growth factor plays an important role, growth factor is by receptor tyrosine kinase (receptor tyrosine kinase, RTK) mediated cell external stimulus signal, the functions such as the propagation of regulating cell, differentiation.Observe the impact of Chinese medicine on soft-tissue trauma healing receptor tyrosine kinase activity, result shows that Chinese medicine can strengthen the RTK activity in soft-tissue trauma healing.
3, promote the propagation of new capillary vessel, promote granulation tissue growth to improve the regeneration of permeability and the blood vessel of surface of a wound blood vessel, can improve the blood confession of affected part, promote granulation tissue growth, accelerate the immediate union of the surface of a wound.Herbal mixture promotes the experimental study of rabbit skin wound healing, and result shows that this herbal mixture has significant effect in wound healing, can promote wound reconstructing blood vessel, reduces the infiltration of inflammatory cell, accelerates collagenous fibres hyperplasia and forms scar, prevents wound infection.
4, promote rising transforming growth factor-beta 1 (the transforming growth factor-β 1 that TGF-β 1 expresses, TGF-β 1) Main Function is growth and the differentiation that regulates cell, synthetic and the Apoptosis of inducing cell epimatrix, thereby the healing of promotion wound.By the observation to transforming growth factor-beta and wound healing, result shows that TGF-β 1 expresses and raises at early metaphase, to promoting the synthetic collagen of fibroblast, proteoglycans, fiber connexin and integral protein, strengthening migration of epithelial cells and fibroblast synthetic cell epimatrix has key effect, is an importance of its wound healing.
Manufacture method of the present invention is simple, the product proportioning making is simple, prescription collocation rationally, Promote immunity is reconciled, increase speed of wound healing, be specially: the present invention be take sea cucumber as basestocks, add therein promoting blood circulation and removing blood stasis, hemostasis and pain-relieving, promoting qi circulation and removing obstruction in the collateral, the corresponding traditional Chinese medicinal components of clearing heat and moistening dryness, to improve speed of wound healing, in addition, further add chitin, make sea cucumber effect, herbal function combines with chitin effect, preparation becomes chewable tablets and uses, more independent treatment by Chinese herbs, all effect is remarkable in the speed for the treatment of wound for simple sea cucumber tonic or chitin capsule and pill.
Claims (1)
1. a manufacture method for sea cucumber tablet, is characterized in that, comprises the steps:
The step of getting the raw materials ready:
Alternative following traditional Chinese medicinal components, alternative high-quality sea cucumber, alternative additional material: chitin, starch, dextrin, sweet mellow wine, sweetener, microcrystalline cellulose;
The step of A, cleaning: by madder, pig label grass, Ligusticum wallichii, the root of bidentate achyranthes, China rose, the Radix Astragali, dandelion, garden burnet, the wind-weed, honeysuckle, radix scrophulariae, rheum officinale, Qin Jiu, Chinese cassia tree, is used tumbling-box type medicine-washing machine to clean, and scavenging period is controlled at 5-10 minute, avoids drug effect to run off;
The step of B, demulcen: the traditional Chinese medicinal components that steps A is cleaned up, use water injection type medicine processing device to carry out demulcen operation, demulcen makes the plant cell imbibition of dehydration, and demulcen time 2-3 disappears, for abstraction process creates conditions;
C, above-mentioned component add 12 times of weight amount ethanol, heating and refluxing extraction 3 times, and each 2 hours, No. 3 extracts are merged, decompression recycling ethanol, and to be concentrated into liquor strength be 0.5g crude drug/mL, after suction filtration, when the relative density of filtrate is 20 ℃ 1.2; The large pore resin absorption column that described filtrate flow is 10L through volume, use afterwards deionized water or the distilled water wash-out of 10 times of resin column volumes, use again 95% ethanol elution of 5 times of resin column volumes, collect ethanol eluate, remove alcohol solvent, obtain Chinese medicinal powder, then after 80 order sieve, standby after ultraviolet sterilization;
The step of D, sea cucumber deep processing: fresh and alive sea cucumbers, along belly from first to last complete section open, gill, impurity is cleaned up; Then carry out freeze drying, cryogenic temperature is-20 ~-25 ℃, and vacuum is 5-15Pa, and snap frozen 2-3h puts into pulverizer by the sea cucumber after freeze drying, pulverizes 10-30min, crosses 60 mesh sieves, obtains thick sea cucumber powder; Sea cucumber meal is carried out to ultramicro grinding by airslide disintegrating mill, and time 2-3h, obtains ultra micro sea cucumber powder; Then ultra micro sea cucumber powder is carried out to nanometer pulverizing by high speed shear ultrafine crusher, grinding time is 3-5h;
In container, add pure water, sea cucumber powder after nanometer is pulverized with water with 1: the dissolving of 5-10 mass ratio, obtain sea cucumber milk, take the compound protease of sea cucumber weight 0.3-0.4%, compound protease is the mixture of pepsic bromelain stomach, protease: the mass ratio=2:1 of bromelain, after using pure water that compound protease is dissolved, together with sea cucumber milk, put into enzymatic vessel, standing 1-2min in the microwave environment that is 500-1000w in intensity, carry out the operation of microwave enzymolysis, after enzymolysis completes, by enzymolysis liquid rapidly degree of intensification to 90 ℃ of enzyme 10-30min that go out, complete after the deactivation of enzyme, enzymatic vessel is stopped to heating, enzymolysis liquid is cooled to rapidly to normal temperature, enzymatic vessel purified rinse water, flushing liquor is put into enzymolysis liquid, enzymolysis liquid after cooling is first used to the centrifugal 20min of generic centrifuge, filter, get filtrate, the centrifugal 20min of low temperature ultrahigh speed, filters, and obtains filtrate, by filtrate by nanofiltration with except freshen, residue is crossed 80 mesh sieves, obtains sea cucumber extract,
E, prepare the step of capsule: step C gained Chinese medicinal powder is joined in the sea cucumber extract of step D gained to Chinese medicinal powder: the weight ratio of sea cucumber extract is 1-1.3:1-1.8; After mixing, add additional material, in the pasty state, compression molding, is dried to obtain chewable tablets to the mixture obtaining.
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104585799A (en) * | 2015-01-16 | 2015-05-06 | 青岛老尹家海参股份有限公司 | Warm reinforcing sea cucumber slice and processing method thereof |
| CN105982328A (en) * | 2016-01-07 | 2016-10-05 | 安徽省华银茶油有限公司 | Trepang nourishing tea leaf seed polypeptide lozenge and preparation method thereof |
| CN107668570A (en) * | 2017-11-06 | 2018-02-09 | 刘海涛 | A kind of preparation method of sea cucumber pulvis, sea cucumber tablet and sea cucumber capsule |
| CN107668574A (en) * | 2017-11-17 | 2018-02-09 | 荣成奥汛海洋生物科技有限公司 | A kind of sea cucumber Radiation-proof food and its processing method |
-
2013
- 2013-10-20 CN CN201310492157.6A patent/CN103598623A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104585799A (en) * | 2015-01-16 | 2015-05-06 | 青岛老尹家海参股份有限公司 | Warm reinforcing sea cucumber slice and processing method thereof |
| CN105982328A (en) * | 2016-01-07 | 2016-10-05 | 安徽省华银茶油有限公司 | Trepang nourishing tea leaf seed polypeptide lozenge and preparation method thereof |
| CN107668570A (en) * | 2017-11-06 | 2018-02-09 | 刘海涛 | A kind of preparation method of sea cucumber pulvis, sea cucumber tablet and sea cucumber capsule |
| CN107668574A (en) * | 2017-11-17 | 2018-02-09 | 荣成奥汛海洋生物科技有限公司 | A kind of sea cucumber Radiation-proof food and its processing method |
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Application publication date: 20140226 |