CN103599366A - Manufacturing method of sea cucumber chewing tablets - Google Patents
Manufacturing method of sea cucumber chewing tablets Download PDFInfo
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- CN103599366A CN103599366A CN201310491170.XA CN201310491170A CN103599366A CN 103599366 A CN103599366 A CN 103599366A CN 201310491170 A CN201310491170 A CN 201310491170A CN 103599366 A CN103599366 A CN 103599366A
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Abstract
The invention provides a manufacturing method of sea cucumber chewing tablets, which comprises the following steps: a material preparation step, that is, preparing the following traditional Chinese medicine components, preparing high-quality sea cucumbers, preparing additives of chitin, starch, dextrin, mannitol, a sweetener, and microcrystalline cellulose; A. a cleaning step, that is, cleaning bletilla striata, biota orientalis, folium artemisiae argyi, salvia miltiorrhiza, dragon's blood, bighead atractylodes rhizome, longan, raw rehmannia roots, wild chrysanthemum flowers, phellodendron, pseudo-ginseng, gentrin knotweed, green tangerine peel, and cape jasmine by a drum-type herbal medicine washing machine; B. a herbal medicine infiltrating step; C. preparation of the above components into traditional Chinese medicine powder; D. a sea cucumber deep processing step to obtain a sea cucumber extract; E. a capsule preparation step, that is, adding the traditional Chinese medicine powder obtained in step C into the sea cucumber extract obtained in step D according to a weight ratio of the traditional Chinese medicine powder to the sea cucumber extract of 1-1.3:1-1.8; well mixing, adding the additives to obtain a pasty mixture, tabletting, and drying to obtain the chewing tablets. The manufacturing method of the invention is simple; the prepared product is simple in composition, and reasonable in formula combination, and can promote immune regulation and increase wound healing speed.
Description
technical field:
The present invention relates to Stichopus japonicus deep process technology field, relate in particular to a kind of manufacture method of Stichopus japonicus chewable tablet.
background technology:
Stichopus japonicus is extremely low containing cholesterol, is a kind of typical high protein, low fat, low cholesterol food.Add its fine and tender taste, be easy to digestion, so, be suitable for very much old people, child and the people that has a delicate constitution edible.Stichopus japonicus, because of extremely low containing cholesterol, is the food of a kind of typical high protein, low fat, low cholesterol.Because of fine and tender taste, be easy to digestion again, thus be applicable to very much old people and child, and the person of having a delicate constitution is edible.Taurine in Stichopus japonicus, nicotinic acid etc.; there is nervous system regulation, quick allaying tiredness; the effect of prevention skin aging; the taurine containing in Stichopus japonicus in addition, lysine, methionine etc. almost do not have in vegetable food; the chondroitin sulfate containing in Radix Morinae Bulleyanae and Radix Morinae Bulleyanae mucopolysaccharide; by pharmacological evaluation, prove, to the growth promoter of human body, antiinflammatory skeletonization and prevention failure, promoting wound healing to suppress several cancerous cell has special efficacy.Continuity is old and feeble, allaying tiredness, improve immunity, the natural precious active substances of kind more than 50 such as the ability Stichopus japonicus rich in proteins of enhancing resist the disease, mineral, vitamin, wherein acid mucopolysaccharide and chrondroitin can obviously reduce the quantity of lipofuscin and skin proline in heart tissue, play the effect of slow down aging.In Stichopus japonicus body, 18 contained seed amino acids can strengthen the metabolic function of tissue, and enhancing body cell viability, is suitable for the teenager in growth promoter.Stichopus japonicus energy balance the body water balance, is suitable for the Ms of pregnancy period legs and feet edema.Stichopus japonicus energy allaying tiredness, improves body immunity, strengthens the ability of human body resist the disease, is therefore applicable to very much often middle aged Ms and the man in fatigue state, the sub-health populations such as easy catching a cold, the old people who has a delicate constitution and child.
Other functions of Stichopus japonicus, as eliminated tumor, the anticancer heart that protects: contain a large amount of holothurins in the tissues such as body wall, internal organs and body of gland of Stichopus japonicus, be again holotoxin.Holothurin is a kind of counterpoison, nontoxic to human-body safety, but growth and the transfer of energy inhibition tumor cell, effectively anti-cancer, anticancer, has been widely used in the treatment of hepatocarcinoma, pulmonary carcinoma, gastric cancer, nasopharyngeal carcinoma, osteocarcinoma, lymphatic cancer, ovarian cancer, uterus carcinoma, breast carcinoma, brain cancer leukemia and hands postoperative patient clinically.Improve the frequent beche-de-mer of osteoporosis and can prevent child's rickets, adult's osteoporosis and bone matrix hyperplasia.In gold most distinguished Stichopus japonicus, the element such as abundant calcium, phosphorus, manganese, copper, germanium, silicon is to prevention Infant Rickets, adult's osteoporosis and to skeletal abnormality, deformity, and dentine and enamel development be bad special role.Enhancing development beche-de-mer helps lend some impetus to growth promoter.Abundant arginine, lysine, taurine, calcium, phosphorus, iodine, ferrum, zinc in Stichopus japonicus; it is the important substance that human development grows up; they participate in the physiological activity such as growth promoter, immune regulation, wound healing, reproductive development of human body itself directly; in body energy deposit and running, play an important role; therefore; as postoperative nutriment, Stichopus japonicus can be accelerated the healing rate of wound greatly.
In daily life and medical treatment, wound can hardly be avoided, as wound, operation etc. all can cause certain wound.Due to the situation of wound healing and the development of the state of an illness closely related, therefore wound healing becomes one of focus important in medical research now.In recent years, Chinese herbal medicine is subject to people's favor gradually, and Chinese medicine is just in healthy and strong development, and the research of Chinese herbal medicine supporting wound healing also continues to bring out.Now just to Chinese herbal medicine, promote the effects anb Mechanism of wound healing to be summarized as follows.The traditional Chinese medical science is wanted > > to note to the understanding < < roman class of wound healing to say: " limbs damage in outside, QI and blood is hindered in interior, battalion defends to some extent does not pass through, internal organs by discord." point out after body wound QI and blood lose support, battalion defending to become estranged and causing that coagulation of QI-blood, meridians block, visceral dysfunction.The qi and blood prosperity and decline of wound surface, battalion's strong defensive QI are weak most important to the healing of wound surface, therefore blood circulation promoting and blood stasis dispelling, promoting of the circulation of QI and removing the obstruction in the collaterals are the keys for the treatment of wound.Chinese medicine thinks, wound is caused by exopathogenic factor, and " wound " is more shallow at skin surface, degree, and " wound " refers to the infringement that metal sharp sword causes, the deep muscle that reaches.No matter which kind of wound, all can injure blood network, vascular, occurs hemorrhage, blood stasis or hematoma, and stopping blooding, subsiding a swelling, invigorate blood circulation is the requisite step for the treatment of wound.Chinese medicine promotes the growth of wound surface granulation tissue mainly to concentrate on the aspects such as putrefaction-removing granulation-promoting, expelling the stasis for the new and tonification granulation promoting.
Stichopus japonicus has remarkable result for promotion wound healing, so, usually used as the nutritional supplement after postoperative or wound.The instructions of taking of Stichopus japonicus, still take tonic as main at present, and tonic causes human absorptivity not enough, and the taboo of some culinary arts also usually causes the loss of sea cucumber nutrient composition, as, Stichopus japonicus can not be cooked flavoring agent with vinegar.Therefore, there are on the market some Stichopus japonicus deep processed products, as oral liquid, tablet, capsule, honey refining pill etc., in the process of deep processing, often adds Chinese patent medicine to improve the absorbance of product or to increase other auxiliary functions, but, some formula is unreasonable, for example, Stichopus japonicus can not with Radix Glycyrrhizae compatibility etc.Therefore, it is simple that the present invention aims to provide a kind of manufacture method, and the product proportioning making is simple, and rationally, the manufacture method of a kind of Stichopus japonicus chewable tablet of speed of wound healing is reconciled, increased to Promote immunity in prescription collocation.
summary of the invention:
The object of the invention is to overcome the shortcoming existing in prior art, provide a kind of manufacture method simple, the product proportioning making is simple, and rationally, the manufacture method of a kind of Stichopus japonicus chewable tablet of speed of wound healing is reconciled, increased to Promote immunity in prescription collocation.
To achieve these goals, the invention provides a kind of manufacture method of Stichopus japonicus chewable tablet, wherein, comprise the steps:
The step of getting the raw materials ready:
Alternative following Chinese medicinal components, alternative high-quality Stichopus japonicus, alternative additional material: chitin, starch, dextrin, mannitol, sweeting agent, microcrystalline Cellulose.
The step of A, cleaning: by the Pseudobulbus Bletillae (Rhizoma Bletillae), Cacumen Platycladi, Folium Artemisiae Argyi, Radix Salviae Miltiorrhizae, Sanguis Draxonis, the Rhizoma Atractylodis Macrocephalae, Arillus Longan, Radix Rehmanniae, Flos Chrysanthemi Indici, Cortex Phellodendri, Radix Notoginseng, Rhizoma Polygoni Cuspidati, Pericarpium Citri Reticulatae Viride, Fructus Gardeniae, is used tumbling-box type medicine-washing machine to clean, and scavenging period is controlled at 5-10 minute, avoids drug effect to run off;
The step of B, demulcen: the Chinese medicinal components that steps A is cleaned up, use water injection type medicine processing device to carry out demulcen operation, demulcen makes the plant cell imbibition of dehydration, and demulcen time 2-3 disappears, for abstraction process creates conditions;
C, above-mentioned component add 12 times of weight amount ethanol, heating and refluxing extraction 3 times, and each 2 hours, 3 extracting solution are merged, decompression recycling ethanol, and to be concentrated into liquor strength be 0.5g crude drug/mL, after sucking filtration, when the relative density of filtrate is 20 ℃ 1.2; The macroporous adsorptive resins that described filtrate flow is 10L through volume, use afterwards deionized water or the distilled water eluting of 10 times of resin column volumes, use again 95% ethanol elution of 5 times of resin column volumes, collect ethanol elution, remove alcohol solvent, obtain Chinese medicinal powder, then after 80 order sieve, standby after ultraviolet sterilization;
The step of D, Stichopus japonicus deep processing: fresh and alive sea cucumbers, along abdominal part from first to last complete section open, gill, impurity is cleaned up; Then carry out lyophilization, cryogenic temperature is-20 ~-25 ℃, and vacuum is 5-15Pa, and quick freezing 2-3h puts into pulverizer by the Stichopus japonicus after lyophilization, pulverizes 10-30min, crosses 60 mesh sieves, obtains thick Stichopus japonicus powder; Stichopus japonicus coarse powder is carried out to micronizing by jet mill, and time 2-3h, obtains ultra micro Stichopus japonicus powder; Then ultra micro Stichopus japonicus powder is carried out to nanorize pulverizing by high speed shear ultrafine crusher, grinding time is 3-5h;
In container, add pure water, Stichopus japonicus powder after nanorize is pulverized with water with 1: the dissolving of 5-10 mass ratio, obtain sea cucumber milk, take the compound protease of Stichopus japonicus weight 0.3-0.4%, compound protease is the mixture of pepsic bromelain stomach, protease: the mass ratio=2:1 of bromelain, after using pure water that compound protease is dissolved, together with sea cucumber milk, put into enzymatic vessel, standing 1-2min in the microwave environment that is 500-1000w in intensity, carry out the operation of microwave enzymolysis, after enzymolysis completes, by enzymolysis solution rapidly degree of intensification to 90 ℃ of enzyme denaturing 10-30min, complete after the deactivation of enzyme, enzymatic vessel is stopped to heating, enzymolysis solution is cooled to rapidly to room temperature, enzymatic vessel purified rinse water, flushing liquor is put into enzymolysis solution, enzymolysis solution after cooling is first used to the centrifugal 20min of generic centrifuge, filter, get filtrate, the centrifugal 20min of low temperature ultrahigh speed, filters, and obtains filtrate, by filtrate by nanofiltration with except freshen, residue is crossed 80 mesh sieves, obtains sea cucumber extract,
E, prepare the step of capsule: step C gained Chinese medicinal powder is joined in the sea cucumber extract of step D gained to Chinese medicinal powder: the weight ratio of sea cucumber extract is 1-1.3:1-1.8; After mix homogeneously, add additional material, in the pasty state, compression molding, is dried to obtain chewable tablet to the mixture obtaining.
When prepared by the present invention, select the active component of following parts by weight:
Middle spice: Pseudobulbus Bletillae (Rhizoma Bletillae) 30-50 part, Cacumen Platycladi 20-40 part, Folium Artemisiae Argyi 20-40 part, Radix Salviae Miltiorrhizae 20-40 part, Sanguis Draxonis 10-30 part, Rhizoma Atractylodis Macrocephalae 10-30 part, Arillus Longan 10-30 part, Radix Rehmanniae 10-30 part, Flos Chrysanthemi Indici 10-30 part, Cortex Phellodendri 10-30 part, Radix Notoginseng 10-30 part, Rhizoma Polygoni Cuspidati 10-30 part, Pericarpium Citri Reticulatae Viride 10-30 part, Fructus Gardeniae 10-30 part
Basestocks: Stichopus japonicus 300-500 part;
Additional material: chitin 3-6 part, starch 10-20 part, dextrin 5-10 part, mannitol 3-6 part, sweeting agent 1-4 part, microcrystalline Cellulose 1-4 part.
Or, comprise according to the following active component of parts by weight configuration:
Middle spice: Pseudobulbus Bletillae (Rhizoma Bletillae) 30-40 part, Cacumen Platycladi 20-30 part, Folium Artemisiae Argyi 20-30 part, Radix Salviae Miltiorrhizae 20-30 part, Sanguis Draxonis 10-20 part, Rhizoma Atractylodis Macrocephalae 10-20 part, Arillus Longan 10-20 part, Radix Rehmanniae 10-20 part, Flos Chrysanthemi Indici 10-20 part, Cortex Phellodendri 10-20 part, Radix Notoginseng 10-20 part, Rhizoma Polygoni Cuspidati 10-20 part, Pericarpium Citri Reticulatae Viride 10-20 part, Fructus Gardeniae 10-20 part
Basestocks: Stichopus japonicus 300-400 part;
Additional material: chitin 3-5 part, starch 10-15 part, dextrin 5-8 part, mannitol 3-5 part, sweeting agent 1-3 part, microcrystalline Cellulose 1-3 part.
Or, comprise according to the following active component of parts by weight configuration:
Middle spice: Pseudobulbus Bletillae (Rhizoma Bletillae) 40-50 part, Cacumen Platycladi 30-40 part, Folium Artemisiae Argyi 30-40 part, Radix Salviae Miltiorrhizae 30-40 part, Sanguis Draxonis 20-30 part, Rhizoma Atractylodis Macrocephalae 20-30 part, Arillus Longan 20-30 part, Radix Rehmanniae 20-30 part, Flos Chrysanthemi Indici 20-30 part, Cortex Phellodendri 20-30 part, Radix Notoginseng 20-30 part, Rhizoma Polygoni Cuspidati 20-30 part, Pericarpium Citri Reticulatae Viride 20-30 part, Fructus Gardeniae 20-30 part
Basestocks: Stichopus japonicus 400-500 part;
Additional material: chitin 4-6 part, starch 15-20 part, dextrin 8-10 part, mannitol 4-6 part, sweeting agent 2-4 part, microcrystalline Cellulose 2-4 part.
Or, comprise according to the following active component of parts by weight configuration:
Middle spice: middle spice: Pseudobulbus Bletillae (Rhizoma Bletillae) 35-45 part, Cacumen Platycladi 25-35 part, Folium Artemisiae Argyi 25-35 part, Radix Salviae Miltiorrhizae 25-35 part, Sanguis Draxonis 15-25 part, Rhizoma Atractylodis Macrocephalae 15-25 part, Arillus Longan 15-25 part, Radix Rehmanniae 15-25 part, Flos Chrysanthemi Indici 15-25 part, Cortex Phellodendri 15-25 part, Radix Notoginseng 15-25 part, Rhizoma Polygoni Cuspidati 15-25 part, Pericarpium Citri Reticulatae Viride 15-25 part, Fructus Gardeniae 15-25 part
Basestocks: Stichopus japonicus 350-450 part;
Additional material: chitin 4-5 part, starch 12-18 part, dextrin 6-9 part, mannitol 2-5 part, sweeting agent 2-3 part, microcrystalline Cellulose 2-3 part.
Composition in additional material is as follows:
The medical knowledge effect of chitin (being chitin) is as follows: 1, trauma hemostasis, the chitin of platelet in blood is combined, and can improve the adhesion of wound tissue, makes fast local vascular shrink, and reduces hemorrhage quantity.2, improve speed of wound healing, the basic substance of volume is badly in need of in new histiocytic propagation, formation, and hyaluronic acid is important material.Carapace mass-energy increases hyaluronic quantity in tissue, promotes the formation of cell membrane.And in activating cell process, produce a large amount of collagen fiber, and form rapidly compact substance skin, can scar.3, chitin can be prevented and treated wound face and infects, and chitin is used in wound part outward can bacteria growing inhibiting, and domestic and foreign literature report chitin applies wound in vitro can suppress gram positive bacteria and Candida albicans growth, and 5 mg/ml bacteriostasis rates reach 75 ~ 100%; Can increase the local cytophagous quantity of wound and activity; Eliminate in time slough, promote the formation of granulation tissue.This three large key element that forms wound wound healing, complements each other and comprehensively works.4, the application of chitin on Orthopeadic Surgery, chitin is as the damaged portion of bone implant, owing to helping platelet adhesion to accelerate coagulation, show good anastalsis, at chitinous phagocyte, the macrophage of assembling volume around, the invasion and attack that suppress local pathogen have the effect that obvious accelerated bone is repaired.
Starch: relatively more conventional is corn starch, its character is highly stable, inoperative with most drug, price is also more cheap, and hygroscopicity is little, appearance luster good, in actual production, often mix use with the good Icing Sugar of compressibility, dextrin, this is because the compressibility of starch is poor, if use separately, can make the tablet of extrusion too loose.
Dextrin: dextrin is the general name of Starch Hydrolysis intermediate product, its chemical formula is (C6H10O5) nXH2O, its hydrotrope is about 80%, dissolves slowlyer in cold water, is soluble in hot water, is insoluble to ethanol.Also be called traditionally as height and stick with paste (high viscosity dextrin), there is stronger caking property.
Microcrystalline Cellulose: microcrystalline Cellulose (Microcrystalline cellulose, MCC) be cellulose partial hydrolysis and the less crystallinity cellulose of the degree of polymerization that makes, there is good compressibility, there is stronger adhesion, the tablet being pressed into has more greatly hardness, and " dry adhesives " that can be used as direct powder compression used.
Mannitol: mannitol is granule or Powdered, heat absorption when orally-dissolvable, thereby have cooling feeling, and have certain sweet taste concurrently simultaneously, in mouth, without sand type, therefore be suitable for preparing chewable tablet.
Sweeting agent (preferably Icing Sugar): Icing Sugar means the white powder that crystallinity sucrose forms after cold drying is pulverized, and its advantage is that bonding force is strong, can be used to increase the hardness of tablet, and makes the smooth surface of tablet attractive in appearance.
Advantage of the present invention is: manufacture method is simple, and the product proportioning making is simple, and rationally, Promote immunity is reconciled, increased speed of wound healing, is specially in prescription collocation:
The present invention be take Stichopus japonicus as basestocks, add therein blood circulation promoting and blood stasis dispelling, hemostasis and pain-relieving, promoting of the circulation of QI and removing the obstruction in the collaterals, the corresponding Chinese medicinal components of clearing heat and moistening dryness, to improve speed of wound healing, in addition, further add chitin, Stichopus japonicus effect, herbal function are combined with chitin effect, preparation becomes chewable tablet to be used, and all effect is remarkable in the speed for the treatment of wound for more independent treatment by Chinese herbs, simple Stichopus japonicus tonic or chitin soft gelatin capsule.
the specific embodiment:
The step of getting the raw materials ready:
Alternative following Chinese medicinal components, alternative high-quality Stichopus japonicus, alternative additional material: chitin, starch, dextrin, mannitol, sweeting agent, microcrystalline Cellulose.
The step of A, cleaning: by the Pseudobulbus Bletillae (Rhizoma Bletillae), Cacumen Platycladi, Folium Artemisiae Argyi, Radix Salviae Miltiorrhizae, Sanguis Draxonis, the Rhizoma Atractylodis Macrocephalae, Arillus Longan, Radix Rehmanniae, Flos Chrysanthemi Indici, Cortex Phellodendri, Radix Notoginseng, Rhizoma Polygoni Cuspidati, Pericarpium Citri Reticulatae Viride, Fructus Gardeniae, is used tumbling-box type medicine-washing machine to clean, and scavenging period is controlled at 5-10 minute, avoids drug effect to run off;
The step of B, demulcen: the Chinese medicinal components that steps A is cleaned up, use water injection type medicine processing device to carry out demulcen operation, demulcen makes the plant cell imbibition of dehydration, and demulcen time 2-3 disappears, for abstraction process creates conditions;
C, above-mentioned component add 12 times of weight amount ethanol, heating and refluxing extraction 3 times, and each 2 hours, 3 extracting solution are merged, decompression recycling ethanol, and to be concentrated into liquor strength be 0.5g crude drug/mL, after sucking filtration, when the relative density of filtrate is 20 ℃ 1.2; The macroporous adsorptive resins that described filtrate flow is 10L through volume, use afterwards deionized water or the distilled water eluting of 10 times of resin column volumes, use again 95% ethanol elution of 5 times of resin column volumes, collect ethanol elution, remove alcohol solvent, obtain Chinese medicinal powder, then after 80 order sieve, standby after ultraviolet sterilization;
The step of D, Stichopus japonicus deep processing: fresh and alive sea cucumbers, along abdominal part from first to last complete section open, gill, impurity is cleaned up; Then carry out lyophilization, cryogenic temperature is-20 ~-25 ℃, and vacuum is 5-15Pa, and quick freezing 2-3h puts into pulverizer by the Stichopus japonicus after lyophilization, pulverizes 10-30min, crosses 60 mesh sieves, obtains thick Stichopus japonicus powder; Stichopus japonicus coarse powder is carried out to micronizing by jet mill, and time 2-3h, obtains ultra micro Stichopus japonicus powder; Then ultra micro Stichopus japonicus powder is carried out to nanorize pulverizing by high speed shear ultrafine crusher, grinding time is 3-5h;
In container, add pure water, Stichopus japonicus powder after nanorize is pulverized with water with 1: the dissolving of 5-10 mass ratio, obtain sea cucumber milk, take the compound protease of Stichopus japonicus weight 0.3-0.4%, compound protease is the mixture of pepsic bromelain stomach, protease: the mass ratio=2:1 of bromelain, after using pure water that compound protease is dissolved, together with sea cucumber milk, put into enzymatic vessel, standing 1-2min in the microwave environment that is 500-1000w in intensity, carry out the operation of microwave enzymolysis, after enzymolysis completes, by enzymolysis solution rapidly degree of intensification to 90 ℃ of enzyme denaturing 10-30min, complete after the deactivation of enzyme, enzymatic vessel is stopped to heating, enzymolysis solution is cooled to rapidly to room temperature, enzymatic vessel purified rinse water, flushing liquor is put into enzymolysis solution, enzymolysis solution after cooling is first used to the centrifugal 20min of generic centrifuge, filter, get filtrate, the centrifugal 20min of low temperature ultrahigh speed, filters, and obtains filtrate, by filtrate by nanofiltration with except freshen, residue is crossed 80 mesh sieves, obtains sea cucumber extract,
E, prepare the step of capsule: step C gained Chinese medicinal powder is joined in the sea cucumber extract of step D gained to Chinese medicinal powder: the weight ratio of sea cucumber extract is 1-1.3:1-1.8; After mix homogeneously, add additional material, in the pasty state, compression molding, is dried to obtain chewable tablet to the mixture obtaining.
Object lesson 1
Middle spice: 50 parts of the Pseudobulbus Bletillae (Rhizoma Bletillae)s, 40 parts of Cacumen Platycladis, 40 parts of Folium Artemisiae Argyis, 40 parts of Radix Salviae Miltiorrhizaes, 30 parts of Sanguis Draxonis, 30 parts of the Rhizoma Atractylodis Macrocephalaes, 30 parts of Arillus Longans, 30 parts of Radix Rehmanniae, 30 parts of Flos Chrysanthemi Indicis, 30 parts of Cortex Phellodendris, 30 parts of Radix Notoginseng, 30 parts of Rhizoma Polygoni Cuspidati, 30 parts, Pericarpium Citri Reticulatae Viride, 30 parts of Fructus Gardeniaes,
Basestocks: 500 parts of Stichopus japonicuss;
Additional material: 6 parts of chitins, 20 parts of starch, 10 parts, dextrin, 6 parts, mannitol, 4 parts of sweeting agents, 4 parts of microcrystalline Cellulose.
During preparation, the step of getting the raw materials ready:
Alternative following Chinese medicinal components, alternative high-quality Stichopus japonicus, alternative additional material: chitin, starch, dextrin, mannitol, sweeting agent, microcrystalline Cellulose.
The step of A, cleaning: by the Pseudobulbus Bletillae (Rhizoma Bletillae), Cacumen Platycladi, Folium Artemisiae Argyi, Radix Salviae Miltiorrhizae, Sanguis Draxonis, the Rhizoma Atractylodis Macrocephalae, Arillus Longan, Radix Rehmanniae, Flos Chrysanthemi Indici, Cortex Phellodendri, Radix Notoginseng, Rhizoma Polygoni Cuspidati, Pericarpium Citri Reticulatae Viride, Fructus Gardeniae, is used tumbling-box type medicine-washing machine to clean, and scavenging period is controlled at 5-10 minute, avoids drug effect to run off;
The step of B, demulcen: the Chinese medicinal components that steps A is cleaned up, use water injection type medicine processing device to carry out demulcen operation, demulcen makes the plant cell imbibition of dehydration, and demulcen time 2-3 disappears, for abstraction process creates conditions;
C, above-mentioned component add 12 times of weight amount ethanol, heating and refluxing extraction 3 times, and each 2 hours, 3 extracting solution are merged, decompression recycling ethanol, and to be concentrated into liquor strength be 0.5g crude drug/mL, after sucking filtration, when the relative density of filtrate is 20 ℃ 1.2; The macroporous adsorptive resins that described filtrate flow is 10L through volume, use afterwards deionized water or the distilled water eluting of 10 times of resin column volumes, use again 95% ethanol elution of 5 times of resin column volumes, collect ethanol elution, remove alcohol solvent, obtain Chinese medicinal powder, then after 80 order sieve, standby after ultraviolet sterilization;
The step of D, Stichopus japonicus deep processing: fresh and alive sea cucumbers, along abdominal part from first to last complete section open, gill, impurity is cleaned up; Then carry out lyophilization, cryogenic temperature is-20 ~-25 ℃, and vacuum is 5-15Pa, and quick freezing 2-3h puts into pulverizer by the Stichopus japonicus after lyophilization, pulverizes 10-30min, crosses 60 mesh sieves, obtains thick Stichopus japonicus powder; Stichopus japonicus coarse powder is carried out to micronizing by jet mill, and time 2-3h, obtains ultra micro Stichopus japonicus powder; Then ultra micro Stichopus japonicus powder is carried out to nanorize pulverizing by high speed shear ultrafine crusher, grinding time is 3-5h;
In container, add pure water, Stichopus japonicus powder after nanorize is pulverized with water with 1: the dissolving of 5-10 mass ratio, obtain sea cucumber milk, take the compound protease of Stichopus japonicus weight 0.3-0.4%, compound protease is the mixture of pepsic bromelain stomach, protease: the mass ratio=2:1 of bromelain, after using pure water that compound protease is dissolved, together with sea cucumber milk, put into enzymatic vessel, standing 1-2min in the microwave environment that is 500-1000w in intensity, carry out the operation of microwave enzymolysis, after enzymolysis completes, by enzymolysis solution rapidly degree of intensification to 90 ℃ of enzyme denaturing 10-30min, complete after the deactivation of enzyme, enzymatic vessel is stopped to heating, enzymolysis solution is cooled to rapidly to room temperature, enzymatic vessel purified rinse water, flushing liquor is put into enzymolysis solution, enzymolysis solution after cooling is first used to the centrifugal 20min of generic centrifuge, filter, get filtrate, the centrifugal 20min of low temperature ultrahigh speed, filters, and obtains filtrate, by filtrate by nanofiltration with except freshen, residue is crossed 80 mesh sieves, obtains sea cucumber extract,
E, prepare the step of capsule: step C gained Chinese medicinal powder is joined in the sea cucumber extract of step D gained to Chinese medicinal powder: the weight ratio of sea cucumber extract is 1-1.3:1-1.8; After mix homogeneously, add additional material, in the pasty state, compression molding, is dried to obtain chewable tablet to the mixture obtaining.
Object lesson 2
Middle spice: 30 parts of the Pseudobulbus Bletillae (Rhizoma Bletillae)s, 20 parts of Cacumen Platycladis, 20 parts of Folium Artemisiae Argyis, 20 parts of Radix Salviae Miltiorrhizaes, 10 parts of Sanguis Draxonis, 10 parts of the Rhizoma Atractylodis Macrocephalaes, 10 parts of Arillus Longans, 10 parts of Radix Rehmanniae, 10 parts of Flos Chrysanthemi Indicis, 10 parts of Cortex Phellodendris, 10 parts of Radix Notoginseng, 10 parts of Rhizoma Polygoni Cuspidati, 10 parts, Pericarpium Citri Reticulatae Viride, 10 parts of Fructus Gardeniaes,
Basestocks: 300 parts of Stichopus japonicuss;
Additional material: 3 parts of chitins, 10 parts of starch, 5 parts, dextrin, 3 parts, mannitol, 1 part of sweeting agent, 1 part of microcrystalline Cellulose.
During preparation, the step of getting the raw materials ready:
Alternative following Chinese medicinal components, alternative high-quality Stichopus japonicus, alternative additional material: chitin, starch, dextrin, mannitol, sweeting agent, microcrystalline Cellulose.
The step of A, cleaning: by the Pseudobulbus Bletillae (Rhizoma Bletillae), Cacumen Platycladi, Folium Artemisiae Argyi, Radix Salviae Miltiorrhizae, Sanguis Draxonis, the Rhizoma Atractylodis Macrocephalae, Arillus Longan, Radix Rehmanniae, Flos Chrysanthemi Indici, Cortex Phellodendri, Radix Notoginseng, Rhizoma Polygoni Cuspidati, Pericarpium Citri Reticulatae Viride, Fructus Gardeniae, is used tumbling-box type medicine-washing machine to clean, and scavenging period is controlled at 5-10 minute, avoids drug effect to run off;
The step of B, demulcen: the Chinese medicinal components that steps A is cleaned up, use water injection type medicine processing device to carry out demulcen operation, demulcen makes the plant cell imbibition of dehydration, and demulcen time 2-3 disappears, for abstraction process creates conditions;
C, above-mentioned component add 12 times of weight amount ethanol, heating and refluxing extraction 3 times, and each 2 hours, 3 extracting solution are merged, decompression recycling ethanol, and to be concentrated into liquor strength be 0.5g crude drug/mL, after sucking filtration, when the relative density of filtrate is 20 ℃ 1.2; The macroporous adsorptive resins that described filtrate flow is 10L through volume, use afterwards deionized water or the distilled water eluting of 10 times of resin column volumes, use again 95% ethanol elution of 5 times of resin column volumes, collect ethanol elution, remove alcohol solvent, obtain Chinese medicinal powder, then after 80 order sieve, standby after ultraviolet sterilization;
The step of D, Stichopus japonicus deep processing: fresh and alive sea cucumbers, along abdominal part from first to last complete section open, gill, impurity is cleaned up; Then carry out lyophilization, cryogenic temperature is-20 ~-25 ℃, and vacuum is 5-15Pa, and quick freezing 2-3h puts into pulverizer by the Stichopus japonicus after lyophilization, pulverizes 10-30min, crosses 60 mesh sieves, obtains thick Stichopus japonicus powder; Stichopus japonicus coarse powder is carried out to micronizing by jet mill, and time 2-3h, obtains ultra micro Stichopus japonicus powder; Then ultra micro Stichopus japonicus powder is carried out to nanorize pulverizing by high speed shear ultrafine crusher, grinding time is 3-5h;
In container, add pure water, Stichopus japonicus powder after nanorize is pulverized with water with 1: the dissolving of 5-10 mass ratio, obtain sea cucumber milk, take the compound protease of Stichopus japonicus weight 0.3-0.4%, compound protease is the mixture of pepsic bromelain stomach, protease: the mass ratio=2:1 of bromelain, after using pure water that compound protease is dissolved, together with sea cucumber milk, put into enzymatic vessel, standing 1-2min in the microwave environment that is 500-1000w in intensity, carry out the operation of microwave enzymolysis, after enzymolysis completes, by enzymolysis solution rapidly degree of intensification to 90 ℃ of enzyme denaturing 10-30min, complete after the deactivation of enzyme, enzymatic vessel is stopped to heating, enzymolysis solution is cooled to rapidly to room temperature, enzymatic vessel purified rinse water, flushing liquor is put into enzymolysis solution, enzymolysis solution after cooling is first used to the centrifugal 20min of generic centrifuge, filter, get filtrate, the centrifugal 20min of low temperature ultrahigh speed, filters, and obtains filtrate, by filtrate by nanofiltration with except freshen, residue is crossed 80 mesh sieves, obtains sea cucumber extract,
E, prepare the step of capsule: step C gained Chinese medicinal powder is joined in the sea cucumber extract of step D gained to Chinese medicinal powder: the weight ratio of sea cucumber extract is 1-1.3:1-1.8; After mix homogeneously, add additional material, in the pasty state, compression molding, is dried to obtain chewable tablet to the mixture obtaining.
Object lesson 3
Middle spice: 40 parts of the Pseudobulbus Bletillae (Rhizoma Bletillae)s, 30 parts of Cacumen Platycladis, 30 parts of Folium Artemisiae Argyis, 30 parts of Radix Salviae Miltiorrhizaes, 20 parts of Sanguis Draxonis, 20 parts of the Rhizoma Atractylodis Macrocephalaes, 20 parts of Arillus Longans, 20 parts of Radix Rehmanniae, 20 parts of Flos Chrysanthemi Indicis, 20 parts of Cortex Phellodendris, 20 parts of Radix Notoginseng, 20 parts of Rhizoma Polygoni Cuspidati, 20 parts, Pericarpium Citri Reticulatae Viride, 20 parts of Fructus Gardeniaes,
Basestocks: 400 parts of Stichopus japonicuss;
Additional material: 5 parts of chitins, 15 parts of starch, 8 parts, dextrin, 5 parts, mannitol, 3 parts of sweeting agents, 3 parts of microcrystalline Cellulose.
During preparation, the step of getting the raw materials ready:
Alternative following Chinese medicinal components, alternative high-quality Stichopus japonicus, alternative additional material: chitin, starch, dextrin, mannitol, sweeting agent, microcrystalline Cellulose.
The step of A, cleaning: by the Pseudobulbus Bletillae (Rhizoma Bletillae), Cacumen Platycladi, Folium Artemisiae Argyi, Radix Salviae Miltiorrhizae, Sanguis Draxonis, the Rhizoma Atractylodis Macrocephalae, Arillus Longan, Radix Rehmanniae, Flos Chrysanthemi Indici, Cortex Phellodendri, Radix Notoginseng, Rhizoma Polygoni Cuspidati, Pericarpium Citri Reticulatae Viride, Fructus Gardeniae, is used tumbling-box type medicine-washing machine to clean, and scavenging period is controlled at 5-10 minute, avoids drug effect to run off;
The step of B, demulcen: the Chinese medicinal components that steps A is cleaned up, use water injection type medicine processing device to carry out demulcen operation, demulcen makes the plant cell imbibition of dehydration, and demulcen time 2-3 disappears, for abstraction process creates conditions;
C, above-mentioned component add 12 times of weight amount ethanol, heating and refluxing extraction 3 times, and each 2 hours, 3 extracting solution are merged, decompression recycling ethanol, and to be concentrated into liquor strength be 0.5g crude drug/mL, after sucking filtration, when the relative density of filtrate is 20 ℃ 1.2; The macroporous adsorptive resins that described filtrate flow is 10L through volume, use afterwards deionized water or the distilled water eluting of 10 times of resin column volumes, use again 95% ethanol elution of 5 times of resin column volumes, collect ethanol elution, remove alcohol solvent, obtain Chinese medicinal powder, then after 80 order sieve, standby after ultraviolet sterilization;
The step of D, Stichopus japonicus deep processing: fresh and alive sea cucumbers, along abdominal part from first to last complete section open, gill, impurity is cleaned up; Then carry out lyophilization, cryogenic temperature is-20 ~-25 ℃, and vacuum is 5-15Pa, and quick freezing 2-3h puts into pulverizer by the Stichopus japonicus after lyophilization, pulverizes 10-30min, crosses 60 mesh sieves, obtains thick Stichopus japonicus powder; Stichopus japonicus coarse powder is carried out to micronizing by jet mill, and time 2-3h, obtains ultra micro Stichopus japonicus powder; Then ultra micro Stichopus japonicus powder is carried out to nanorize pulverizing by high speed shear ultrafine crusher, grinding time is 3-5h;
In container, add pure water, Stichopus japonicus powder after nanorize is pulverized with water with 1: the dissolving of 5-10 mass ratio, obtain sea cucumber milk, take the compound protease of Stichopus japonicus weight 0.3-0.4%, compound protease is the mixture of pepsic bromelain stomach, protease: the mass ratio=2:1 of bromelain, after using pure water that compound protease is dissolved, together with sea cucumber milk, put into enzymatic vessel, standing 1-2min in the microwave environment that is 500-1000w in intensity, carry out the operation of microwave enzymolysis, after enzymolysis completes, by enzymolysis solution rapidly degree of intensification to 90 ℃ of enzyme denaturing 10-30min, complete after the deactivation of enzyme, enzymatic vessel is stopped to heating, enzymolysis solution is cooled to rapidly to room temperature, enzymatic vessel purified rinse water, flushing liquor is put into enzymolysis solution, enzymolysis solution after cooling is first used to the centrifugal 20min of generic centrifuge, filter, get filtrate, the centrifugal 20min of low temperature ultrahigh speed, filters, and obtains filtrate, by filtrate by nanofiltration with except freshen, residue is crossed 80 mesh sieves, obtains sea cucumber extract,
E, prepare the step of capsule: step C gained Chinese medicinal powder is joined in the sea cucumber extract of step D gained to Chinese medicinal powder: the weight ratio of sea cucumber extract is 1-1.3:1-1.8; After mix homogeneously, add additional material, in the pasty state, compression molding, is dried to obtain chewable tablet to the mixture obtaining.
eating effect comparison of the present invention:
50 white mice of take are laboratory animal, by the long 3mm of rear thigh incised wound of 50 white mice, the wound of dark 1mm, respectively smear mercurochrome and wrap gauze, and then every 10 is one group,
First group is the present invention of experimental group feeding,
Second group as a control group 1, do not feed.
The 3rd group as a control group 2, feeding step C gained Chinese medicinal powder.
The 3rd group as a control group 3, feeding contains chitinous soft gelatin capsule.
The 4th group as a control group 4, the sea cucumber extract of feeding step D gained.
The 5th group as a control group 5, direct feeding Stichopus japonicus.
After 3 weeks, wound is carried out to gross specimen observation, biomechanics test, gross specimen observed result: experimental group wound heals completely, falls crust naturally;
Matched group 1, not healing.Heal completely compared with 12 days experimental group evenings
Matched group 2, healing, does not fall crust substantially; Heal completely compared with 5 days experimental group evenings
Matched group 3, healing, does not fall crust substantially; Heal completely compared with 7 days experimental group evenings
To group, according to 4, healing, does not fall crust substantially; Heal completely compared with 6 days experimental group evenings
Matched group 5, healing, healed completely compared with 10 days experimental group evenings
Biomechanics test result is as following table:
As can be seen from the above table, the present invention has the effect of quickly-healing wound.
immunity comparison:
Select 10 white mice feeding tradition Stichopus japonicus tablets as a control group,
Select 10 white mice feedings the present invention group as a comparison.
Be compared as follows:
Wherein, the absorption of comparable group calcium and mineral is fast, and propagation bacillus bifidus, lactobacillus number is many, and the index of blood fat, blood glucose, cholesterol regulating is low compared with matched group.3-5 is placed in dark environment and the environment that is exposed to the sun repeatedly in day, the matched group probability of catching an illness is large, so comparable group immunity is strong.
In the present invention, Chinese medicine composition is for the pharmacy mechanism evidence that promotes wound healing:
1, lower the expression of HIF-1 alpha levels, rise VEGF, histiocyte can be induced and be produced HIF-1 Hypoxia Inducible Factor-1 (hypoxia-inducible factor-1 under hypoxic-ischemic environment, HIF-1, comprise two kinds of HIF-1 α and HIF-1 β), wherein HIF-1 α can modulating vascular endothelial cell growth factor (ECGF) (vascular endothelial growth factor, VEGF), the expression of endothelin-1, erythropoietin etc., promote formation and the vascular remodeling of new vessels, thereby start wound repair mechanism.By observing benefiting qi and removing blood stasis Chinese medicine, promote the impact of diabetic skin ulcer Rats Exposed To Hypoxia inducible factor-1 and vascular endothelial cell growth factor, result shows that benefiting qi and removing blood stasis Chinese medicine can be by lowering the expression of HIF-1 α, the expression of rise VEGF, improve ischemia anaerobic condition, impel angiogenesis, thus wound healing.
2, the receptor RTK activity in enhancing wound healing is in the process of wound healing, somatomedin plays an important role, somatomedin is by receptor tyrosine kinase (receptor tyrosine kinase, RTK) mediated cell external stimulus signal, the functions such as the propagation of regulating cell, differentiation.Observe the impact of Chinese medicine on soft-tissue trauma healing receptor tyrosine kinase activity, result shows that Chinese medicine can strengthen the RTK activity in soft-tissue trauma healing.
3, promote the propagation of new capillary vessel, promote granulation tissue growth to improve the regeneration of permeability and the blood vessel of wound surface blood vessel, can improve the blood confession of affected part, promote granulation tissue growth, accelerate the immediate union of wound surface.Herbal mixture promotes the experimentation of rabbit skin wound healing, and result shows that this herbal mixture has significant effect in wound healing, can promote wound reconstructing blood vessel, reduces the infiltration of inflammatory cell, accelerates collagen fiber hypertrophy and forms cicatrix, prevents wound infection.
4, promote rising transforming growth factor-beta 1 (the transforming growth factor-β 1 that TGF-β 1 expresses, TGF-β 1) Main Function is growth and the differentiation that regulates cell, synthetic and the apoptosis of inducing cell epimatrix, thereby the healing of promotion wound.By the observation to transforming growth factor-beta and wound healing, result shows that TGF-β 1 expresses and raises at early metaphase, to promoting the synthetic collagen protein of fibroblast, Dan Baiduotang proteoglycan PG, fiber connexin and integral protein, strengthening migration of epithelial cells and fibroblast synthetic cell epimatrix has key effect, is an importance of its wound healing.
Manufacture method of the present invention is simple, the product proportioning making is simple, prescription collocation rationally, Promote immunity is reconciled, increase speed of wound healing, be specially: the present invention be take Stichopus japonicus as basestocks, add therein blood circulation promoting and blood stasis dispelling, hemostasis and pain-relieving, promoting of the circulation of QI and removing the obstruction in the collaterals, the corresponding Chinese medicinal components of clearing heat and moistening dryness, to improve speed of wound healing, in addition, further add chitin, make Stichopus japonicus effect, herbal function combines with chitin effect, preparation becomes chewable tablet and uses, more independent treatment by Chinese herbs, all effect is remarkable in the speed for the treatment of wound for simple Stichopus japonicus tonic or chitin soft gelatin capsule.
Claims (1)
1. a manufacture method for Stichopus japonicus chewable tablet, is characterized in that, comprises the steps:
The step of getting the raw materials ready:
Alternative following Chinese medicinal components, alternative high-quality Stichopus japonicus, alternative additional material: chitin, starch, dextrin, mannitol, sweeting agent, microcrystalline Cellulose;
The step of A, cleaning: by the Pseudobulbus Bletillae (Rhizoma Bletillae), Cacumen Platycladi, Folium Artemisiae Argyi, Radix Salviae Miltiorrhizae, Sanguis Draxonis, the Rhizoma Atractylodis Macrocephalae, Arillus Longan, Radix Rehmanniae, Flos Chrysanthemi Indici, Cortex Phellodendri, Radix Notoginseng, Rhizoma Polygoni Cuspidati, Pericarpium Citri Reticulatae Viride, Fructus Gardeniae, is used tumbling-box type medicine-washing machine to clean, and scavenging period is controlled at 5-10 minute, avoids drug effect to run off;
The step of B, demulcen: the Chinese medicinal components that steps A is cleaned up, use water injection type medicine processing device to carry out demulcen operation, demulcen makes the plant cell imbibition of dehydration, and demulcen time 2-3 disappears, for abstraction process creates conditions;
C, above-mentioned component add 12 times of weight amount ethanol, heating and refluxing extraction 3 times, and each 2 hours, 3 extracting solution are merged, decompression recycling ethanol, and to be concentrated into liquor strength be 0.5g crude drug/mL, after sucking filtration, when the relative density of filtrate is 20 ℃ 1.2; The macroporous adsorptive resins that described filtrate flow is 10L through volume, use afterwards deionized water or the distilled water eluting of 10 times of resin column volumes, use again 95% ethanol elution of 5 times of resin column volumes, collect ethanol elution, remove alcohol solvent, obtain Chinese medicinal powder, then after 80 order sieve, standby after ultraviolet sterilization;
The step of D, Stichopus japonicus deep processing: fresh and alive sea cucumbers, along abdominal part from first to last complete section open, gill, impurity is cleaned up; Then carry out lyophilization, cryogenic temperature is-20 ~-25 ℃, and vacuum is 5-15Pa, and quick freezing 2-3h puts into pulverizer by the Stichopus japonicus after lyophilization, pulverizes 10-30min, crosses 60 mesh sieves, obtains thick Stichopus japonicus powder; Stichopus japonicus coarse powder is carried out to micronizing by jet mill, and time 2-3h, obtains ultra micro Stichopus japonicus powder; Then ultra micro Stichopus japonicus powder is carried out to nanorize pulverizing by high speed shear ultrafine crusher, grinding time is 3-5h;
In container, add pure water, Stichopus japonicus powder after nanorize is pulverized with water with 1: the dissolving of 5-10 mass ratio, obtain sea cucumber milk, take the compound protease of Stichopus japonicus weight 0.3-0.4%, compound protease is the mixture of pepsic bromelain stomach, protease: the mass ratio=2:1 of bromelain, after using pure water that compound protease is dissolved, together with sea cucumber milk, put into enzymatic vessel, standing 1-2min in the microwave environment that is 500-1000w in intensity, carry out the operation of microwave enzymolysis, after enzymolysis completes, by enzymolysis solution rapidly degree of intensification to 90 ℃ of enzyme denaturing 10-30min, complete after the deactivation of enzyme, enzymatic vessel is stopped to heating, enzymolysis solution is cooled to rapidly to room temperature, enzymatic vessel purified rinse water, flushing liquor is put into enzymolysis solution, enzymolysis solution after cooling is first used to the centrifugal 20min of generic centrifuge, filter, get filtrate, the centrifugal 20min of low temperature ultrahigh speed, filters, and obtains filtrate, by filtrate by nanofiltration with except freshen, residue is crossed 80 mesh sieves, obtains sea cucumber extract,
E, prepare the step of capsule: step C gained Chinese medicinal powder is joined in the sea cucumber extract of step D gained to Chinese medicinal powder: the weight ratio of sea cucumber extract is 1-1.3:1-1.8; After mix homogeneously, add additional material, in the pasty state, compression molding, is dried to obtain chewable tablet to the mixture obtaining.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105168756A (en) * | 2015-10-29 | 2015-12-23 | 惠州市康祥生物技术开发有限公司 | Chewable tablets containing Chinese mugwort leaf extract |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105168756A (en) * | 2015-10-29 | 2015-12-23 | 惠州市康祥生物技术开发有限公司 | Chewable tablets containing Chinese mugwort leaf extract |
| CN105168756B (en) * | 2015-10-29 | 2019-02-22 | 惠州市康祥生物技术开发有限公司 | A kind of chewable tablets containing Folium Artemisiae Argyi extract |
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