CN103598622A - Sea cucumber nutrient tablet and application method thereof - Google Patents
Sea cucumber nutrient tablet and application method thereof Download PDFInfo
- Publication number
- CN103598622A CN103598622A CN201310492156.1A CN201310492156A CN103598622A CN 103598622 A CN103598622 A CN 103598622A CN 201310492156 A CN201310492156 A CN 201310492156A CN 103598622 A CN103598622 A CN 103598622A
- Authority
- CN
- China
- Prior art keywords
- sea cucumber
- parts
- wound
- tablet
- day
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 241000251511 Holothuroidea Species 0.000 title claims abstract description 121
- 235000015097 nutrients Nutrition 0.000 title claims abstract description 21
- 238000000034 method Methods 0.000 title claims abstract description 20
- 229920002101 Chitin Polymers 0.000 claims abstract description 29
- 235000000346 sugar Nutrition 0.000 claims abstract description 20
- 244000144730 Amygdalus persica Species 0.000 claims abstract description 19
- 244000020518 Carthamus tinctorius Species 0.000 claims abstract description 19
- 235000003255 Carthamus tinctorius Nutrition 0.000 claims abstract description 19
- 240000007311 Commiphora myrrha Species 0.000 claims abstract description 19
- 235000006965 Commiphora myrrha Nutrition 0.000 claims abstract description 19
- 229920001353 Dextrin Polymers 0.000 claims abstract description 19
- 239000004375 Dextrin Substances 0.000 claims abstract description 19
- 244000219416 Hypericum japonicum Species 0.000 claims abstract description 19
- 229920000168 Microcrystalline cellulose Polymers 0.000 claims abstract description 19
- 235000007265 Myrrhis odorata Nutrition 0.000 claims abstract description 19
- 244000197580 Poria cocos Species 0.000 claims abstract description 19
- 235000008599 Poria cocos Nutrition 0.000 claims abstract description 19
- 235000006040 Prunus persica var persica Nutrition 0.000 claims abstract description 19
- 235000019425 dextrin Nutrition 0.000 claims abstract description 19
- 229910052602 gypsum Inorganic materials 0.000 claims abstract description 19
- 239000010440 gypsum Substances 0.000 claims abstract description 19
- 235000019813 microcrystalline cellulose Nutrition 0.000 claims abstract description 19
- 229920002472 Starch Polymers 0.000 claims abstract description 18
- 239000008107 starch Substances 0.000 claims abstract description 18
- 235000019698 starch Nutrition 0.000 claims abstract description 18
- 230000002980 postoperative effect Effects 0.000 claims abstract description 17
- 239000008108 microcrystalline cellulose Substances 0.000 claims abstract description 16
- 229940016286 microcrystalline cellulose Drugs 0.000 claims abstract description 16
- 230000003203 everyday effect Effects 0.000 claims abstract description 14
- 235000012054 meals Nutrition 0.000 claims abstract description 12
- 239000007910 chewable tablet Substances 0.000 claims description 19
- 241000050051 Chelone glabra Species 0.000 claims description 18
- 235000003956 Luffa Nutrition 0.000 claims description 18
- 241001078983 Tetradium ruticarpum Species 0.000 claims description 18
- 239000010231 banlangen Substances 0.000 claims description 18
- 235000009508 confectionery Nutrition 0.000 claims description 16
- MYSWGUAQZAJSOK-UHFFFAOYSA-N ciprofloxacin Chemical compound C12=CC(N3CCNCC3)=C(F)C=C2C(=O)C(C(=O)O)=CN1C1CC1 MYSWGUAQZAJSOK-UHFFFAOYSA-N 0.000 claims description 15
- 239000009910 sargent gloryvine Substances 0.000 claims description 15
- 244000050983 Luffa operculata Species 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract description 32
- 239000000843 powder Substances 0.000 abstract description 31
- 230000029663 wound healing Effects 0.000 abstract description 25
- 238000002360 preparation method Methods 0.000 abstract description 7
- 230000003832 immune regulation Effects 0.000 abstract description 2
- 230000001055 chewing effect Effects 0.000 abstract 4
- 235000017166 Bambusa arundinacea Nutrition 0.000 abstract 1
- 235000017491 Bambusa tulda Nutrition 0.000 abstract 1
- 241000675108 Citrus tangerina Species 0.000 abstract 1
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 abstract 1
- 241000334160 Isatis Species 0.000 abstract 1
- 244000280244 Luffa acutangula Species 0.000 abstract 1
- 235000009814 Luffa aegyptiaca Nutrition 0.000 abstract 1
- 229930195725 Mannitol Natural products 0.000 abstract 1
- 244000082204 Phyllostachys viridis Species 0.000 abstract 1
- 235000015334 Phyllostachys viridis Nutrition 0.000 abstract 1
- 241000405414 Rehmannia Species 0.000 abstract 1
- 241000501098 Sargentodoxa Species 0.000 abstract 1
- 241000207929 Scutellaria Species 0.000 abstract 1
- 239000011425 bamboo Substances 0.000 abstract 1
- 238000001802 infusion Methods 0.000 abstract 1
- 239000000594 mannitol Substances 0.000 abstract 1
- 235000010355 mannitol Nutrition 0.000 abstract 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 55
- 206010052428 Wound Diseases 0.000 description 32
- 208000027418 Wounds and injury Diseases 0.000 description 32
- 239000004365 Protease Substances 0.000 description 24
- 239000000706 filtrate Substances 0.000 description 20
- 230000000694 effects Effects 0.000 description 19
- 239000003814 drug Substances 0.000 description 18
- 241000219138 Luffa Species 0.000 description 17
- 239000000284 extract Substances 0.000 description 17
- 239000007788 liquid Substances 0.000 description 17
- 239000000463 material Substances 0.000 description 17
- 108091005804 Peptidases Proteins 0.000 description 16
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 description 16
- 235000019419 proteases Nutrition 0.000 description 16
- 210000004369 blood Anatomy 0.000 description 14
- 239000008280 blood Substances 0.000 description 14
- 239000000203 mixture Substances 0.000 description 14
- 235000013599 spices Nutrition 0.000 description 13
- 150000001875 compounds Chemical class 0.000 description 12
- 230000002255 enzymatic effect Effects 0.000 description 12
- 239000011347 resin Substances 0.000 description 12
- 229920005989 resin Polymers 0.000 description 12
- 210000004027 cell Anatomy 0.000 description 11
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 10
- 230000035876 healing Effects 0.000 description 10
- 238000012545 processing Methods 0.000 description 9
- 108010004032 Bromelains Proteins 0.000 description 8
- 102000004190 Enzymes Human genes 0.000 description 8
- 108090000790 Enzymes Proteins 0.000 description 8
- 235000019835 bromelain Nutrition 0.000 description 8
- 239000002775 capsule Substances 0.000 description 8
- 238000004108 freeze drying Methods 0.000 description 8
- 238000000227 grinding Methods 0.000 description 8
- 238000010438 heat treatment Methods 0.000 description 8
- 230000036039 immunity Effects 0.000 description 8
- 235000013336 milk Nutrition 0.000 description 8
- 239000008267 milk Substances 0.000 description 8
- 210000004080 milk Anatomy 0.000 description 8
- 230000008569 process Effects 0.000 description 8
- 230000001737 promoting effect Effects 0.000 description 8
- 102100032742 Histone-lysine N-methyltransferase SETD2 Human genes 0.000 description 7
- 101000654725 Homo sapiens Histone-lysine N-methyltransferase SETD2 Proteins 0.000 description 7
- 230000035611 feeding Effects 0.000 description 7
- 102000005789 Vascular Endothelial Growth Factors Human genes 0.000 description 6
- 108010019530 Vascular Endothelial Growth Factors Proteins 0.000 description 6
- 238000010521 absorption reaction Methods 0.000 description 6
- 229940079593 drug Drugs 0.000 description 6
- 102000027426 receptor tyrosine kinases Human genes 0.000 description 6
- 108091008598 receptor tyrosine kinases Proteins 0.000 description 6
- XOAAWQZATWQOTB-UHFFFAOYSA-N taurine Chemical compound NCCS(O)(=O)=O XOAAWQZATWQOTB-UHFFFAOYSA-N 0.000 description 6
- 206010039509 Scab Diseases 0.000 description 5
- 235000012000 cholesterol Nutrition 0.000 description 5
- 238000001816 cooling Methods 0.000 description 5
- 238000011161 development Methods 0.000 description 5
- 230000018109 developmental process Effects 0.000 description 5
- 239000003826 tablet Substances 0.000 description 5
- 241000196324 Embryophyta Species 0.000 description 4
- 206010063560 Excessive granulation tissue Diseases 0.000 description 4
- 102000004887 Transforming Growth Factor beta Human genes 0.000 description 4
- 108090001012 Transforming Growth Factor beta Proteins 0.000 description 4
- 210000001015 abdomen Anatomy 0.000 description 4
- 230000015572 biosynthetic process Effects 0.000 description 4
- 230000017531 blood circulation Effects 0.000 description 4
- 238000004140 cleaning Methods 0.000 description 4
- 238000000748 compression moulding Methods 0.000 description 4
- 230000009849 deactivation Effects 0.000 description 4
- 230000006837 decompression Effects 0.000 description 4
- 230000018044 dehydration Effects 0.000 description 4
- 238000006297 dehydration reaction Methods 0.000 description 4
- 239000008367 deionised water Substances 0.000 description 4
- 229910021641 deionized water Inorganic materials 0.000 description 4
- 239000012153 distilled water Substances 0.000 description 4
- 230000000857 drug effect Effects 0.000 description 4
- 238000010828 elution Methods 0.000 description 4
- 238000000605 extraction Methods 0.000 description 4
- 238000011010 flushing procedure Methods 0.000 description 4
- 210000001126 granulation tissue Anatomy 0.000 description 4
- 230000012010 growth Effects 0.000 description 4
- 230000023597 hemostasis Effects 0.000 description 4
- 238000005213 imbibition Methods 0.000 description 4
- 239000012535 impurity Substances 0.000 description 4
- 238000002347 injection Methods 0.000 description 4
- 239000007924 injection Substances 0.000 description 4
- 238000002156 mixing Methods 0.000 description 4
- 238000001728 nano-filtration Methods 0.000 description 4
- 235000011837 pasties Nutrition 0.000 description 4
- 239000006187 pill Substances 0.000 description 4
- 239000011148 porous material Substances 0.000 description 4
- 102000004169 proteins and genes Human genes 0.000 description 4
- 108090000623 proteins and genes Proteins 0.000 description 4
- 238000010298 pulverizing process Methods 0.000 description 4
- 238000004064 recycling Methods 0.000 description 4
- 238000010992 reflux Methods 0.000 description 4
- 230000002000 scavenging effect Effects 0.000 description 4
- 239000002904 solvent Substances 0.000 description 4
- 230000001954 sterilising effect Effects 0.000 description 4
- 238000004659 sterilization and disinfection Methods 0.000 description 4
- 210000002784 stomach Anatomy 0.000 description 4
- 239000000126 substance Substances 0.000 description 4
- 238000000967 suction filtration Methods 0.000 description 4
- ZRKFYGHZFMAOKI-QMGMOQQFSA-N tgfbeta Chemical compound C([C@H](NC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCSC)C(C)C)[C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(O)=O)C1=CC=C(O)C=C1 ZRKFYGHZFMAOKI-QMGMOQQFSA-N 0.000 description 4
- 210000001519 tissue Anatomy 0.000 description 4
- 230000001256 tonic effect Effects 0.000 description 4
- 238000005406 washing Methods 0.000 description 4
- -1 10 parts Polymers 0.000 description 3
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 3
- 206010028980 Neoplasm Diseases 0.000 description 3
- 208000001132 Osteoporosis Diseases 0.000 description 3
- 241000531207 Oxera splendida Species 0.000 description 3
- 230000001093 anti-cancer Effects 0.000 description 3
- 210000004204 blood vessel Anatomy 0.000 description 3
- 239000011575 calcium Substances 0.000 description 3
- 229910052791 calcium Inorganic materials 0.000 description 3
- 230000004087 circulation Effects 0.000 description 3
- 235000013305 food Nutrition 0.000 description 3
- 241000411851 herbal medicine Species 0.000 description 3
- 208000014674 injury Diseases 0.000 description 3
- 230000007246 mechanism Effects 0.000 description 3
- 230000002265 prevention Effects 0.000 description 3
- 229960003080 taurine Drugs 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- 230000008733 trauma Effects 0.000 description 3
- 241000965254 Apostichopus japonicus Species 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 2
- 229920002683 Glycosaminoglycan Polymers 0.000 description 2
- 208000032843 Hemorrhage Diseases 0.000 description 2
- 229930188089 Holothurin Natural products 0.000 description 2
- 102000016878 Hypoxia-Inducible Factor 1 Human genes 0.000 description 2
- 108010028501 Hypoxia-Inducible Factor 1 Proteins 0.000 description 2
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 2
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 description 2
- 239000004472 Lysine Substances 0.000 description 2
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 2
- 102000046299 Transforming Growth Factor beta1 Human genes 0.000 description 2
- 101800002279 Transforming growth factor beta-1 Proteins 0.000 description 2
- 108010073929 Vascular Endothelial Growth Factor A Proteins 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 210000001772 blood platelet Anatomy 0.000 description 2
- 210000000988 bone and bone Anatomy 0.000 description 2
- 201000011510 cancer Diseases 0.000 description 2
- 235000010980 cellulose Nutrition 0.000 description 2
- 229920002678 cellulose Polymers 0.000 description 2
- 239000001913 cellulose Substances 0.000 description 2
- 230000000052 comparative effect Effects 0.000 description 2
- 230000004069 differentiation Effects 0.000 description 2
- 230000029087 digestion Effects 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 230000002708 enhancing effect Effects 0.000 description 2
- 210000002950 fibroblast Anatomy 0.000 description 2
- 239000003102 growth factor Substances 0.000 description 2
- 235000008216 herbs Nutrition 0.000 description 2
- 230000007062 hydrolysis Effects 0.000 description 2
- 238000006460 hydrolysis reaction Methods 0.000 description 2
- 229910052500 inorganic mineral Inorganic materials 0.000 description 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 2
- 235000004213 low-fat Nutrition 0.000 description 2
- 239000011707 mineral Substances 0.000 description 2
- 229910052698 phosphorus Inorganic materials 0.000 description 2
- 239000011574 phosphorus Substances 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 208000007442 rickets Diseases 0.000 description 2
- 231100000241 scar Toxicity 0.000 description 2
- 210000004872 soft tissue Anatomy 0.000 description 2
- 230000008467 tissue growth Effects 0.000 description 2
- 229940099456 transforming growth factor beta 1 Drugs 0.000 description 2
- 230000002792 vascular Effects 0.000 description 2
- 210000001835 viscera Anatomy 0.000 description 2
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 description 1
- SQDAZGGFXASXDW-UHFFFAOYSA-N 5-bromo-2-(trifluoromethoxy)pyridine Chemical compound FC(F)(F)OC1=CC=C(Br)C=N1 SQDAZGGFXASXDW-UHFFFAOYSA-N 0.000 description 1
- 239000004475 Arginine Substances 0.000 description 1
- 239000000592 Artificial Cell Substances 0.000 description 1
- 241000186000 Bifidobacterium Species 0.000 description 1
- 208000003174 Brain Neoplasms Diseases 0.000 description 1
- 206010006187 Breast cancer Diseases 0.000 description 1
- 208000026310 Breast neoplasm Diseases 0.000 description 1
- 241000222122 Candida albicans Species 0.000 description 1
- 229920002567 Chondroitin Polymers 0.000 description 1
- 229920001287 Chondroitin sulfate Polymers 0.000 description 1
- 102000008186 Collagen Human genes 0.000 description 1
- 108010035532 Collagen Proteins 0.000 description 1
- 102000010970 Connexin Human genes 0.000 description 1
- 108050001175 Connexin Proteins 0.000 description 1
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 1
- 229920002261 Corn starch Polymers 0.000 description 1
- 102100033902 Endothelin-1 Human genes 0.000 description 1
- 101800004490 Endothelin-1 Proteins 0.000 description 1
- 241000192125 Firmicutes Species 0.000 description 1
- 206010021143 Hypoxia Diseases 0.000 description 1
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 description 1
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 description 1
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 description 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 208000002454 Nasopharyngeal Carcinoma Diseases 0.000 description 1
- 206010061306 Nasopharyngeal cancer Diseases 0.000 description 1
- PVNIIMVLHYAWGP-UHFFFAOYSA-N Niacin Chemical compound OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 description 1
- 206010030113 Oedema Diseases 0.000 description 1
- 241000283973 Oryctolagus cuniculus Species 0.000 description 1
- ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 description 1
- 102000016611 Proteoglycans Human genes 0.000 description 1
- 108010067787 Proteoglycans Proteins 0.000 description 1
- 241000700159 Rattus Species 0.000 description 1
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 description 1
- 206010040943 Skin Ulcer Diseases 0.000 description 1
- 206010072170 Skin wound Diseases 0.000 description 1
- 208000005718 Stomach Neoplasms Diseases 0.000 description 1
- 208000002495 Uterine Neoplasms Diseases 0.000 description 1
- 208000032594 Vascular Remodeling Diseases 0.000 description 1
- 206010048038 Wound infection Diseases 0.000 description 1
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- 239000011149 active material Substances 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 230000022972 amelogenesis Effects 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 230000033115 angiogenesis Effects 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 230000006907 apoptotic process Effects 0.000 description 1
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 description 1
- 210000000476 body water Anatomy 0.000 description 1
- 229940095731 candida albicans Drugs 0.000 description 1
- 210000000170 cell membrane Anatomy 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- DLGJWSVWTWEWBJ-HGGSSLSASA-N chondroitin Chemical compound CC(O)=N[C@@H]1[C@H](O)O[C@H](CO)[C@H](O)[C@@H]1OC1[C@H](O)[C@H](O)C=C(C(O)=O)O1 DLGJWSVWTWEWBJ-HGGSSLSASA-N 0.000 description 1
- 229940059329 chondroitin sulfate Drugs 0.000 description 1
- 229920001436 collagen Polymers 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 229910052802 copper Inorganic materials 0.000 description 1
- 239000010949 copper Substances 0.000 description 1
- 239000008120 corn starch Substances 0.000 description 1
- 229940099112 cornstarch Drugs 0.000 description 1
- 230000002354 daily effect Effects 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 210000004268 dentin Anatomy 0.000 description 1
- 230000013860 dentinogenesis Effects 0.000 description 1
- 206010012601 diabetes mellitus Diseases 0.000 description 1
- 235000015872 dietary supplement Nutrition 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 230000004064 dysfunction Effects 0.000 description 1
- 230000008030 elimination Effects 0.000 description 1
- 238000003379 elimination reaction Methods 0.000 description 1
- 210000002919 epithelial cell Anatomy 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 201000010934 exostosis Diseases 0.000 description 1
- 210000003414 extremity Anatomy 0.000 description 1
- 238000001125 extrusion Methods 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 239000000945 filler Substances 0.000 description 1
- 229910052732 germanium Inorganic materials 0.000 description 1
- GNPVGFCGXDBREM-UHFFFAOYSA-N germanium atom Chemical compound [Ge] GNPVGFCGXDBREM-UHFFFAOYSA-N 0.000 description 1
- 210000004907 gland Anatomy 0.000 description 1
- 229930182470 glycoside Natural products 0.000 description 1
- 150000002338 glycosides Chemical class 0.000 description 1
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 1
- 229910052737 gold Inorganic materials 0.000 description 1
- 239000010931 gold Substances 0.000 description 1
- 210000005003 heart tissue Anatomy 0.000 description 1
- MAWWITJOQDJRJF-ADBICINLSA-M holothurin Chemical compound [Na+].O[C@@H]1[C@@H](OC)[C@H](O)[C@@H](C)O[C@H]1O[C@@H]1[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O)[C@H](O[C@H]3[C@@H](OC[C@H]([C@@H]3O)OS([O-])(=O)=O)O[C@@H]3C([C@H]4[C@](C=5[C@H]([C@@]6(CC[C@]7(O)[C@](C)([C@H]8OC(C)(C)CC8)OC(=O)[C@@]76[C@@H](O)C=5)C)CC4)(C)CC3)(C)C)O[C@@H]2C)O)O[C@H](C)[C@H]1O MAWWITJOQDJRJF-ADBICINLSA-M 0.000 description 1
- 235000012907 honey Nutrition 0.000 description 1
- 229920002674 hyaluronan Polymers 0.000 description 1
- 229960003160 hyaluronic acid Drugs 0.000 description 1
- 239000003752 hydrotrope Substances 0.000 description 1
- 201000010930 hyperostosis Diseases 0.000 description 1
- 206010020718 hyperplasia Diseases 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 230000008595 infiltration Effects 0.000 description 1
- 238000001764 infiltration Methods 0.000 description 1
- 210000004969 inflammatory cell Anatomy 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 239000013067 intermediate product Substances 0.000 description 1
- 230000009545 invasion Effects 0.000 description 1
- PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical compound II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 description 1
- 229910052742 iron Inorganic materials 0.000 description 1
- 230000000302 ischemic effect Effects 0.000 description 1
- 235000014655 lactic acid Nutrition 0.000 description 1
- 239000004310 lactic acid Substances 0.000 description 1
- 210000002414 leg Anatomy 0.000 description 1
- 208000032839 leukemia Diseases 0.000 description 1
- 201000007270 liver cancer Diseases 0.000 description 1
- 208000014018 liver neoplasm Diseases 0.000 description 1
- 201000005202 lung cancer Diseases 0.000 description 1
- 208000020816 lung neoplasm Diseases 0.000 description 1
- 239000002932 luster Substances 0.000 description 1
- 210000002751 lymph Anatomy 0.000 description 1
- 210000002540 macrophage Anatomy 0.000 description 1
- WPBNNNQJVZRUHP-UHFFFAOYSA-L manganese(2+);methyl n-[[2-(methoxycarbonylcarbamothioylamino)phenyl]carbamothioyl]carbamate;n-[2-(sulfidocarbothioylamino)ethyl]carbamodithioate Chemical compound [Mn+2].[S-]C(=S)NCCNC([S-])=S.COC(=O)NC(=S)NC1=CC=CC=C1NC(=S)NC(=O)OC WPBNNNQJVZRUHP-UHFFFAOYSA-L 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000001404 mediated effect Effects 0.000 description 1
- SQFDQLBYJKFDDO-UHFFFAOYSA-K merbromin Chemical compound [Na+].[Na+].C=12C=C(Br)C(=O)C=C2OC=2C([Hg]O)=C([O-])C(Br)=CC=2C=1C1=CC=CC=C1C([O-])=O SQFDQLBYJKFDDO-UHFFFAOYSA-K 0.000 description 1
- 229940008716 mercurochrome Drugs 0.000 description 1
- 230000007102 metabolic function Effects 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 230000031864 metaphase Effects 0.000 description 1
- 229930182817 methionine Natural products 0.000 description 1
- 230000005012 migration Effects 0.000 description 1
- 238000013508 migration Methods 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 230000001114 myogenic effect Effects 0.000 description 1
- 201000011216 nasopharynx carcinoma Diseases 0.000 description 1
- 210000000653 nervous system Anatomy 0.000 description 1
- 235000001968 nicotinic acid Nutrition 0.000 description 1
- 229960003512 nicotinic acid Drugs 0.000 description 1
- 239000011664 nicotinic acid Substances 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 210000001539 phagocyte Anatomy 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 230000001766 physiological effect Effects 0.000 description 1
- 238000006116 polymerization reaction Methods 0.000 description 1
- 238000009702 powder compression Methods 0.000 description 1
- 230000035935 pregnancy Effects 0.000 description 1
- 238000007670 refining Methods 0.000 description 1
- 230000008929 regeneration Effects 0.000 description 1
- 238000011069 regeneration method Methods 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 230000001850 reproductive effect Effects 0.000 description 1
- 230000000630 rising effect Effects 0.000 description 1
- 239000004576 sand Substances 0.000 description 1
- 229910052710 silicon Inorganic materials 0.000 description 1
- 239000010703 silicon Substances 0.000 description 1
- 231100001055 skeletal defect Toxicity 0.000 description 1
- 230000009759 skin aging Effects 0.000 description 1
- 231100000019 skin ulcer Toxicity 0.000 description 1
- QUCDWLYKDRVKMI-UHFFFAOYSA-M sodium;3,4-dimethylbenzenesulfonate Chemical compound [Na+].CC1=CC=C(S([O-])(=O)=O)C=C1C QUCDWLYKDRVKMI-UHFFFAOYSA-M 0.000 description 1
- 201000000498 stomach carcinoma Diseases 0.000 description 1
- 238000005728 strengthening Methods 0.000 description 1
- 125000000185 sucrose group Chemical group 0.000 description 1
- 230000008093 supporting effect Effects 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 235000019605 sweet taste sensations Nutrition 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 210000004881 tumor cell Anatomy 0.000 description 1
- 210000000689 upper leg Anatomy 0.000 description 1
- 206010046766 uterine cancer Diseases 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
- 239000000052 vinegar Substances 0.000 description 1
- 235000021419 vinegar Nutrition 0.000 description 1
- 230000009278 visceral effect Effects 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
- 230000037314 wound repair Effects 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L17/00—Food-from-the-sea products; Fish products; Fish meal; Fish-egg substitutes; Preparation or treatment thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Nutrition Science (AREA)
- Chemical & Material Sciences (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Mycology (AREA)
- Botany (AREA)
- Marine Sciences & Fisheries (AREA)
- Zoology (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
The invention provides a sea cucumber tablet which comprises the following active components: peach seeds, myrrh, safflowers, bamboo shavings, tangerine peel, fructus evodiae, hypericum japonicum, poria cocos, loofah sponge, raw rehmannia roots, sargentodoxa vine, isatis roots, scutellaria, gypsum, sea cucumber, chitin, starch, dextrin, mannitol, sugar powder, and microcrystalline cellulose. The application method of the sea cucumber nutrient tablet comprises the following steps: A. chewing, that is, chewing 1-2 chewing tablets before meal every day for postoperative patients; B. infusion with water, that is, taking 1 chewing tablet infused with 50 ml of water after meal every day for postoperative patients. The sea cucumber nutrient tablet of the invention is simple in preparation, and reasonable in formula combination, can promote immune regulation, and increase wound healing speed.
Description
technical field:
The present invention relates to sea cucumber deep process technology field, relate in particular to a kind of sea cucumber nutrient sheet and using method thereof.
background technology:
Sea cucumber is extremely low containing cholesterol, is a kind of typical high protein, low fat, low cholesterol food.Add its fine and tender taste, be easy to digestion, so, be suitable for very much the elderly, children and the people that has a delicate constitution edible.Sea cucumber, because of extremely low containing cholesterol, is the food of a kind of typical high protein, low fat, low cholesterol.Because of fine and tender taste, be easy to digestion again, thus be applicable to very much the elderly and children, and the person of having a delicate constitution is edible.Taurine in sea cucumber, niacin etc.; there is the nervous system of adjusting, elimination fatigue fast; the effect of prevention skin aging; the taurine containing in sea cucumber in addition, lysine, methionine etc. almost do not have in vegetable food; the chondroitin sulfate containing in stichopus japonicus and stichopus japonicus mucopolysaccharide; by pharmacological evaluation, prove, to the growing of human body, anti-inflammatory skeletonization and prevention failure, promoting wound healing to suppress several cancer cells has special efficacy.Continuity is old and feeble, eliminate tired, improve immunity, the ability sea cucumber that strengthens resist the disease is rich in the natural precious active materials of kind more than 50 such as protein, mineral matter, vitamin, wherein acid mucopolysaccharide and chondroitin can obviously reduce the quantity of lipofuscin and skin proline in heart tissue, play the effect delaying senility.In sea cucumber body, 18 contained seed amino acids can strengthen the metabolic function of tissue, and enhanced machine body cell vigor, is suitable for the teenager in growing.Sea cucumber energy balance the body water balance, is suitable for the Ms of pregnancy period legs and feet edema.Sea cucumber can be eliminated tired, improves body immunity, strengthens the ability of human body resist the disease, is therefore applicable to very much often middle aged Ms and the man in fatigue state, the sub-health populations such as easy catching a cold, the elderly who has a delicate constitution and children.
Other functions of sea cucumber, as eliminated tumour, the anticancer heart that protects: contain a large amount of holothurins in the tissues such as body wall, internal organ and body of gland of sea cucumber, be again Sea Cucumber Glycosides.Holothurin is a kind of counterpoison, nontoxic to human-body safety, but growth and the transfer of energy inhibition tumor cell, effectively anti-cancer, anticancer, has been widely used in the treatment of liver cancer, lung cancer, cancer of the stomach, nasopharyngeal carcinoma, osteocarcinoma, lymph cancer, oophoroma, the cancer of the uterus, breast cancer, cancer of the brain leukaemia and hand postoperative patient clinically.Improve the frequent beche-de-mer of osteoporosis and can prevent children's rickets, adult's osteoporosis and hyperostosis.In gold most distinguished sea cucumber, the element such as abundant calcium, phosphorus, manganese, copper, germanium, silicon is to prevention Infant Rickets, adult's osteoporosis and to skeletal abnormality, deformity, and dentine and enamel development be bad special role.Enhancing development beche-de-mer helps lend some impetus to and grows.Abundant arginine, lysine, taurine, calcium, phosphorus, iodine, iron, zinc in sea cucumber; it is the important substance that human development grows up; they participate in the physiological activities such as the growing of human body itself, immune regulation, wound healing, reproductive development directly; in body energy deposit and running, play an important role; therefore; as postoperative nutriment, sea cucumber can be accelerated the healing rate of wound greatly.
In daily life and medical treatment, wound can hardly be avoided, as wound, operation etc. all can cause certain wound.Due to the situation of wound healing and the development of the state of an illness closely related, therefore wound healing becomes one of focus important in medical research now.In recent years, Chinese herbal medicine is subject to people's favor gradually, and traditional Chinese medicine is just in healthy and strong development, and the research of Chinese herbal medicine supporting wound healing also continues to bring out.Now just to Chinese herbal medicine, promote the effects anb Mechanism of wound healing to be summarized as follows.The traditional Chinese medical science is wanted > > to note to the understanding < < roman class of wound healing to say: " limbs damage in outside, qi and blood is hindered in interior, battalion defends to some extent does not pass through, internal organs by discord." point out after body wound qi and blood lose support, battalion defending to become estranged and causing that qi and blood stagnation, channels and collaterals block, visceral dysfunction.The qi and blood prosperity and decline of the surface of a wound, battalion defend strong and weak most important to the healing of the surface of a wound, therefore promoting blood circulation and removing blood stasis, promoting qi circulation and removing obstruction in the collateral is the key for the treatment of wound.Traditional Chinese medicine thinks, wound is caused by external cause, and " wound " is more shallow at skin surface, degree, and " wound " refers to the infringement that metal sharp sword causes, the deep muscle that reaches.No matter which kind of wound, all can injure blood network, vascular, occurs hemorrhage, hemostasis or hemotoncus, and stopping blooding, subsiding a swelling, invigorate blood circulation is the requisite step for the treatment of wound.Traditional Chinese medicine promotes the growth of surface of a wound granulation tissue mainly to concentrate on the aspects such as putrefaction-removing granulation-promoting, expelling the stasis for the new and help myogenic.
Sea cucumber has remarkable result for promotion wound healing, so, usually used as the nutritional supplement after postoperative or wound.The instructions of taking of sea cucumber, still take tonic as main at present, and tonic causes human absorptivity not enough, and the taboo of some culinary arts also usually causes the loss of sea cucumber nutrient composition, as, sea cucumber can not be cooked flavouring with vinegar.Therefore, there are on the market some sea cucumber deep processed products, as oral liquid, tablet, capsule, honey refining pill etc., in the process of deep processing, often adds Chinese patent drug to improve the absorptivity of product or to increase other auxiliary functions, but, some formula is unreasonable, for example, sea cucumber can not with Radix Glycyrrhizae compatibility etc.Therefore, it is simple that the present invention aims to provide a kind of proportioning, and rationally, a kind of sea cucumber nutrient sheet and the using method thereof of speed of wound healing reconciled, increased to Promote immunity in prescription collocation.
summary of the invention:
The object of the invention is to overcome the shortcoming existing in prior art, provide a kind of proportioning simple, rationally, a kind of sea cucumber nutrient sheet of speed of wound healing and using method thereof are reconciled, increased to Promote immunity in prescription collocation.
To achieve these goals, the invention provides a kind of sea cucumber nutrient sheet, wherein, comprise following active component: peach kernel, myrrh, safflower, caulis bambusae in taenian, Exocarpium Citri Rubrum, evodia rutaecarpa, hypericum japonicum, Poria cocos, luffa, radix rehmanniae recen, Sargent gloryvine, Radix Isatidis, the root of large-flowered skullcap, gypsum, sea cucumber; Chitin, starch, dextrin, sweet mellow wine, Icing Sugar, microcrystalline cellulose.
The using method of described sea cucumber nutrient sheet, wherein, comprises the steps:
A, chew: postoperative patient, chewable tablets 1-2 ante cibum every day sheet,
B, soaked: postoperative patient, chewable tablets every day is a slice after meal, the soaked 50ml of a slice.
The sea cucumber nutrient sheet that the present invention uses, wherein, comprises according to the following active component of parts by weight configuration:
Middle spice: peach kernel 30-50 part, myrrh 20-40 part, safflower 20-40 part, caulis bambusae in taenian 20-40 part, Exocarpium Citri Rubrum 10-30 part, evodia rutaecarpa 10-30 part, hypericum japonicum 10-30 part, Poria cocos 10-30 part, luffa 10-30 part, radix rehmanniae recen 10-30 part, Sargent gloryvine 10-30 part, Radix Isatidis 10-30 part, root of large-flowered skullcap 10-30 part, gypsum 10-30 part
Basestocks: sea cucumber 300-500 part;
Additional material: chitin 3-6 part, starch 10-20 part, dextrin 5-10 part, sweet mellow wine 3-6 part, Icing Sugar 1-4 part, microcrystalline cellulose 1-4 part.
Or, comprise according to the following active component of parts by weight configuration:
Middle spice: peach kernel 30-40 part, myrrh 20-30 part, safflower 20-30 part, caulis bambusae in taenian 20-30 part, Exocarpium Citri Rubrum 10-20 part, evodia rutaecarpa 10-20 part, hypericum japonicum 10-20 part, Poria cocos 10-20 part, luffa 10-20 part, radix rehmanniae recen 10-20 part, Sargent gloryvine 10-20 part, Radix Isatidis 10-20 part, root of large-flowered skullcap 10-20 part, gypsum 10-20 part
Basestocks: sea cucumber 300-400 part;
Additional material: chitin 3-5 part, starch 10-15 part, dextrin 5-8 part, sweet mellow wine 3-5 part, Icing Sugar 1-3 part, microcrystalline cellulose 1-3 part.
Or, comprise according to the following active component of parts by weight configuration:
Middle spice: peach kernel 40-50 part, myrrh 30-40 part, safflower 30-40 part, caulis bambusae in taenian 30-40 part, Exocarpium Citri Rubrum 20-30 part, evodia rutaecarpa 20-30 part, hypericum japonicum 20-30 part, Poria cocos 20-30 part, luffa 20-30 part, radix rehmanniae recen 20-30 part, Sargent gloryvine 20-30 part, Radix Isatidis 20-30 part, root of large-flowered skullcap 20-30 part, gypsum 20-30 part
Basestocks: sea cucumber 400-500 part;
Additional material: chitin 4-6 part, starch 15-20 part, dextrin 8-10 part, sweet mellow wine 4-6 part, Icing Sugar 2-4 part, microcrystalline cellulose 2-4 part.
Or, comprise according to the following active component of parts by weight configuration:
Middle spice: middle spice: peach kernel 35-45 part, myrrh 25-35 part, safflower 25-35 part, caulis bambusae in taenian 25-35 part, Exocarpium Citri Rubrum 15-25 part, evodia rutaecarpa 15-25 part, hypericum japonicum 15-25 part, Poria cocos 15-25 part, luffa 15-25 part, radix rehmanniae recen 15-25 part, Sargent gloryvine 15-25 part, Radix Isatidis 15-25 part, root of large-flowered skullcap 15-25 part, gypsum 15-25 part
Basestocks: sea cucumber 350-450 part;
Additional material: chitin 4-5 part, starch 12-18 part, dextrin 6-9 part, sweet mellow wine 2-5 part, Icing Sugar 2-3 part, microcrystalline cellulose 2-3 part.
Object to better implement the present invention, the present invention discloses again the preparation method of sea cucumber nutrient sheet, wherein, comprises the steps:
The step of A, cleaning: by peach kernel, myrrh, safflower, caulis bambusae in taenian, Exocarpium Citri Rubrum, evodia rutaecarpa, hypericum japonicum, Poria cocos, luffa, radix rehmanniae recen, Sargent gloryvine, Radix Isatidis, the root of large-flowered skullcap, gypsum, is used tumbling-box type medicine-washing machine to clean, and scavenging period is controlled at 3-5 minute, avoids drug effect to run off;
The step of B, demulcen: the traditional Chinese medicinal components that steps A is cleaned up, use water injection type medicine processing device to carry out demulcen operation, demulcen makes the plant cell imbibition of dehydration, for abstraction process creates conditions;
C, above-mentioned component add 10 times of weight amount ethanol, heating and refluxing extraction 3 times, and each 2 hours, No. 3 extracts are merged, decompression recycling ethanol, and to be concentrated into liquor strength be 0.5g crude drug/mL, after suction filtration, when the relative density of filtrate is 20 ℃ 1.08; The large pore resin absorption column that described filtrate flow is 10L through volume, use afterwards deionized water or the distilled water wash-out of 10 times of resin column volumes, use again 95% ethanol elution of 5 times of resin column volumes, collect ethanol eluate, remove alcohol solvent, obtain Chinese medicinal powder, then after 80 order sieve, standby after ultraviolet sterilization;
The step of D, sea cucumber deep processing: fresh and alive sea cucumbers, along belly from first to last complete section open, gill, impurity is cleaned up; Then carry out freeze drying, cryogenic temperature is-20 ~-25 ℃, and vacuum is 5-15Pa, and snap frozen 2-3h puts into pulverizer by the sea cucumber after freeze drying, pulverizes 10-30min, crosses 60 mesh sieves, obtains thick sea cucumber powder; Sea cucumber meal is carried out to ultramicro grinding by airslide disintegrating mill, and time 2-3h, obtains ultra micro sea cucumber powder; Then ultra micro sea cucumber powder is carried out to nanometer pulverizing by high speed shear ultrafine crusher, grinding time is 3-5h;
In container, add pure water, sea cucumber powder after nanometer is pulverized with water with 1: the dissolving of 5-10 mass ratio, obtain sea cucumber milk, take the compound protease of sea cucumber weight 0.3-0.4%, compound protease is the mixture of pepsic bromelain stomach, protease: the mass ratio=2:1 of bromelain, after using pure water that compound protease is dissolved, together with sea cucumber milk, put into enzymatic vessel, standing 1-2min in the microwave environment that is 500-1000w in intensity, carry out the operation of microwave enzymolysis, after enzymolysis completes, by enzymolysis liquid rapidly degree of intensification to 90 ℃ of enzyme 10-30min that go out, complete after the deactivation of enzyme, enzymatic vessel is stopped to heating, enzymolysis liquid is cooled to rapidly to normal temperature, enzymatic vessel purified rinse water, flushing liquor is put into enzymolysis liquid, enzymolysis liquid after cooling is first used to the centrifugal 20min of generic centrifuge, filter, get filtrate, the centrifugal 20min of low temperature ultrahigh speed, filters, and obtains filtrate, by filtrate by nanofiltration with except freshen, residue is crossed 100 mesh sieves, obtains sea cucumber extract,
E, prepare the step of capsule: step C gained Chinese medicinal powder is joined in the sea cucumber extract of step D gained to Chinese medicinal powder: the weight ratio of sea cucumber extract is 1-1.2:1-1.5; After mixing, add additional material, in the pasty state, compression molding, is dried to obtain chewable tablets to the mixture obtaining.
Composition in additional material is as follows:
The medical knowledge effect of chitin (being chitin) is as follows: 1, trauma hemostasis, the chitin of blood platelet in blood is combined, and can improve the adhesion of wound tissue, makes fast local vascular shrink, and reduces hemorrhage quantity.2, improve speed of wound healing, the basic substance of volume is badly in need of in new histiocytic propagation, formation, and hyaluronic acid is important material.Crust mass-energy increases hyaluronic quantity in tissue, promotes the formation of cell membrane.And in activating cell process, produce a large amount of collagenous fibres, and form rapidly compact substance skin, can scar.3, chitin can be prevented and treated wound face and infects, and chitin is used in wound part outward can bacteria growing inhibiting, and domestic and foreign literature report chitin applies wound in vitro can suppress gram-positive bacteria and candida albicans growth, and 5 mg/ml bacteriostasis rates reach 75 ~ 100%; Can increase the local cytophagous quantity of wound and activity; Eliminate in time slough, promote the formation of granulation tissue.This three large key element that forms wound wound healing, complements each other and comprehensively works.4, the application of chitin on Orthopeadic Surgery, chitin is as the damaged portion of bone filler, owing to helping platelet adhesion reaction to accelerate aggegation, show good anastalsis, at chitinous phagocyte, the macrophage of assembling volume around, the invasion and attack that suppress local pathogen have the effect that obvious accelerated bone is repaired.
Starch: relatively more conventional is cornstarch, its character is highly stable, inoperative with most drug, price is also more cheap, and hygroscopicity is little, appearance luster good, in actual production, often mix use with the good Icing Sugar of compressibility, dextrin, this is because the compressibility of starch is poor, if use separately, can make the tablet of extrusion too loose.
Dextrin: dextrin is the general name of Starch Hydrolysis intermediate product, its chemical formula is (C6H10O5) nXH2O, its hydrotrope is about 80%, dissolves slowlyer in cold water, is soluble in hot water, is insoluble to ethanol.Also be called traditionally as height and stick with paste (high viscosity dextrin), there is stronger caking property.
Microcrystalline cellulose: microcrystalline cellulose (Microcrystalline cellulose, MCC) be cellulose partial hydrolysis and the less crystallinity cellulose of the degree of polymerization that makes, there is good compressibility, there is stronger adhesion, the tablet being pressed into has more greatly hardness, and " dry adhesives " that can be used as direct powder compression used.
Sweet mellow wine: sweet mellow wine is particle or Powdered, heat absorption when orally-dissolvable, thereby have cooling feeling, and have certain sweet taste concurrently simultaneously, in mouth, without sand type, therefore be suitable for preparing chewable tablets.
Icing Sugar (preferably Icing Sugar): Icing Sugar means the white powder that crystallinity sucrose forms after low temperature drying is pulverized, and its advantage is that bonding force is strong, can be used to increase the hardness of tablet, and makes the smooth surface of tablet attractive in appearance.
Advantage of the present invention is: proportioning is simple, and rationally, Promote immunity is reconciled, increased speed of wound healing, is specially in prescription collocation:
The present invention be take sea cucumber as basestocks, add therein promoting blood circulation and removing blood stasis, hemostasis and pain-relieving, promoting qi circulation and removing obstruction in the collateral, the corresponding traditional Chinese medicinal components of clearing heat and moistening dryness, to improve speed of wound healing, in addition, further add chitin, sea cucumber effect, herbal function are combined with chitin effect, preparation becomes chewable tablets to be used, and all effect is remarkable in the speed for the treatment of wound for more independent treatment by Chinese herbs, simple sea cucumber tonic or chitin capsule and pill.
the specific embodiment:
A sea cucumber nutrient sheet, wherein, comprises following active component: peach kernel, myrrh, safflower, caulis bambusae in taenian, Exocarpium Citri Rubrum, evodia rutaecarpa, hypericum japonicum, Poria cocos, luffa, radix rehmanniae recen, Sargent gloryvine, Radix Isatidis, the root of large-flowered skullcap, gypsum, sea cucumber; Chitin, starch, dextrin, sweet mellow wine, Icing Sugar, microcrystalline cellulose.
The using method of described sea cucumber nutrient sheet, wherein, comprises the steps:
A, chew: postoperative patient, chewable tablets 1-2 ante cibum every day sheet,
B, soaked: postoperative patient, chewable tablets every day is a slice after meal, the soaked 50ml of a slice.
Sea cucumber nutrient sheet, wherein, comprises according to the following active component of parts by weight configuration:
Middle spice: peach kernel 30-50 part, myrrh 20-40 part, safflower 20-40 part, caulis bambusae in taenian 20-40 part, Exocarpium Citri Rubrum 10-30 part, evodia rutaecarpa 10-30 part, hypericum japonicum 10-30 part, Poria cocos 10-30 part, luffa 10-30 part, radix rehmanniae recen 10-30 part, Sargent gloryvine 10-30 part, Radix Isatidis 10-30 part, root of large-flowered skullcap 10-30 part, gypsum 10-30 part
Basestocks: sea cucumber 300-500 part;
Additional material: chitin 3-6 part, starch 10-20 part, dextrin 5-10 part, sweet mellow wine 3-6 part, Icing Sugar 1-4 part, microcrystalline cellulose 1-4 part.
Or, comprise according to the following active component of parts by weight configuration:
Middle spice: peach kernel 30-40 part, myrrh 20-30 part, safflower 20-30 part, caulis bambusae in taenian 20-30 part, Exocarpium Citri Rubrum 10-20 part, evodia rutaecarpa 10-20 part, hypericum japonicum 10-20 part, Poria cocos 10-20 part, luffa 10-20 part, radix rehmanniae recen 10-20 part, Sargent gloryvine 10-20 part, Radix Isatidis 10-20 part, root of large-flowered skullcap 10-20 part, gypsum 10-20 part
Basestocks: sea cucumber 300-400 part;
Additional material: chitin 3-5 part, starch 10-15 part, dextrin 5-8 part, sweet mellow wine 3-5 part, Icing Sugar 1-3 part, microcrystalline cellulose 1-3 part.
Or, comprise according to the following active component of parts by weight configuration:
Middle spice: peach kernel 40-50 part, myrrh 30-40 part, safflower 30-40 part, caulis bambusae in taenian 30-40 part, Exocarpium Citri Rubrum 20-30 part, evodia rutaecarpa 20-30 part, hypericum japonicum 20-30 part, Poria cocos 20-30 part, luffa 20-30 part, radix rehmanniae recen 20-30 part, Sargent gloryvine 20-30 part, Radix Isatidis 20-30 part, root of large-flowered skullcap 20-30 part, gypsum 20-30 part
Basestocks: sea cucumber 400-500 part;
Additional material: chitin 4-6 part, starch 15-20 part, dextrin 8-10 part, sweet mellow wine 4-6 part, Icing Sugar 2-4 part, microcrystalline cellulose 2-4 part.
Or, comprise according to the following active component of parts by weight configuration:
Middle spice: middle spice: peach kernel 35-45 part, myrrh 25-35 part, safflower 25-35 part, caulis bambusae in taenian 25-35 part, Exocarpium Citri Rubrum 15-25 part, evodia rutaecarpa 15-25 part, hypericum japonicum 15-25 part, Poria cocos 15-25 part, luffa 15-25 part, radix rehmanniae recen 15-25 part, Sargent gloryvine 15-25 part, Radix Isatidis 15-25 part, root of large-flowered skullcap 15-25 part, gypsum 15-25 part
Basestocks: sea cucumber 350-450 part;
Additional material: chitin 4-5 part, starch 12-18 part, dextrin 6-9 part, sweet mellow wine 2-5 part, Icing Sugar 2-3 part, microcrystalline cellulose 2-3 part.
Object lesson 1
Middle spice: 50 parts, peach kernel, 40 parts of myrrhs, 40 parts, safflower, 40 parts of caulis bambusae in taenians, 30 parts of Exocarpium Citri Rubrums, 30 parts of evodia rutaecarpas, 30 parts of hypericum japonicum, 30 parts, Poria cocos, 30 parts of luffas, 30 parts of radix rehmanniae recens, 30 parts of Sargent gloryvines, 30 parts of Radix Isatidis, 30 parts of the roots of large-flowered skullcap, 30 parts, gypsum,
Basestocks: 500 parts of sea cucumbers;
Additional material: 6 parts of chitins, 20 parts of starch, 10 parts, dextrin, 6 parts, sweet mellow wine, 4 parts of Icing Sugar, 4 parts of microcrystalline celluloses.
During preparation, the step of A, cleaning: by peach kernel, myrrh, safflower, caulis bambusae in taenian, Exocarpium Citri Rubrum, evodia rutaecarpa, hypericum japonicum, Poria cocos, luffa, radix rehmanniae recen, Sargent gloryvine, Radix Isatidis, the root of large-flowered skullcap, gypsum, is used tumbling-box type medicine-washing machine to clean, and scavenging period is controlled at 3-5 minute, avoids drug effect to run off;
The step of B, demulcen: the traditional Chinese medicinal components that steps A is cleaned up, use water injection type medicine processing device to carry out demulcen operation, demulcen makes the plant cell imbibition of dehydration, for abstraction process creates conditions;
C, above-mentioned component add 10 times of weight amount ethanol, heating and refluxing extraction 3 times, and each 2 hours, No. 3 extracts are merged, decompression recycling ethanol, and to be concentrated into liquor strength be 0.5g crude drug/mL, after suction filtration, when the relative density of filtrate is 20 ℃ 1.08; The large pore resin absorption column that described filtrate flow is 10L through volume, use afterwards deionized water or the distilled water wash-out of 10 times of resin column volumes, use again 95% ethanol elution of 5 times of resin column volumes, collect ethanol eluate, remove alcohol solvent, obtain Chinese medicinal powder, then after 80 order sieve, standby after ultraviolet sterilization;
The step of D, sea cucumber deep processing: fresh and alive sea cucumbers, along belly from first to last complete section open, gill, impurity is cleaned up; Then carry out freeze drying, cryogenic temperature is-20 ~-25 ℃, and vacuum is 5-15Pa, and snap frozen 2-3h puts into pulverizer by the sea cucumber after freeze drying, pulverizes 10-30min, crosses 60 mesh sieves, obtains thick sea cucumber powder; Sea cucumber meal is carried out to ultramicro grinding by airslide disintegrating mill, and time 2-3h, obtains ultra micro sea cucumber powder; Then ultra micro sea cucumber powder is carried out to nanometer pulverizing by high speed shear ultrafine crusher, grinding time is 3-5h;
In container, add pure water, sea cucumber powder after nanometer is pulverized with water with 1: the dissolving of 5-10 mass ratio, obtain sea cucumber milk, take the compound protease of sea cucumber weight 0.3-0.4%, compound protease is the mixture of pepsic bromelain stomach, protease: the mass ratio=2:1 of bromelain, after using pure water that compound protease is dissolved, together with sea cucumber milk, put into enzymatic vessel, standing 1-2min in the microwave environment that is 500-1000w in intensity, carry out the operation of microwave enzymolysis, after enzymolysis completes, by enzymolysis liquid rapidly degree of intensification to 90 ℃ of enzyme 10-30min that go out, complete after the deactivation of enzyme, enzymatic vessel is stopped to heating, enzymolysis liquid is cooled to rapidly to normal temperature, enzymatic vessel purified rinse water, flushing liquor is put into enzymolysis liquid, enzymolysis liquid after cooling is first used to the centrifugal 20min of generic centrifuge, filter, get filtrate, the centrifugal 20min of low temperature ultrahigh speed, filters, and obtains filtrate, by filtrate by nanofiltration with except freshen, residue is crossed 100 mesh sieves, obtains sea cucumber extract,
E, prepare the step of capsule: step C gained Chinese medicinal powder is joined in the sea cucumber extract of step D gained to Chinese medicinal powder: the weight ratio of sea cucumber extract is 1-1.2:1-1.5; After mixing, add additional material, in the pasty state, compression molding, is dried to obtain chewable tablets to the mixture obtaining.
The using method of described sea cucumber nutrient sheet, wherein, comprises the steps:
A, chew: postoperative patient, chewable tablets 1-2 ante cibum every day sheet,
B, soaked: postoperative patient, chewable tablets every day is a slice after meal, the soaked 50ml of a slice.
Object lesson 2
Middle spice: 30 parts, peach kernel, 20 parts of myrrhs, 20 parts, safflower, 20 parts of caulis bambusae in taenians, 10 parts of Exocarpium Citri Rubrums, 10 parts of evodia rutaecarpas, 10 parts of hypericum japonicum, 10 parts, Poria cocos, 10 parts of luffas, 10 parts of radix rehmanniae recens, 10 parts of Sargent gloryvines, 10 parts of Radix Isatidis, 10 parts of the roots of large-flowered skullcap, 10 parts, gypsum,
Basestocks: 300 parts of sea cucumbers;
Additional material: 3 parts of chitins, 10 parts of starch, 5 parts, dextrin, 3 parts, sweet mellow wine, 1 part of Icing Sugar, 1 part of microcrystalline cellulose.
During preparation, the step of A, cleaning: by peach kernel, myrrh, safflower, caulis bambusae in taenian, Exocarpium Citri Rubrum, evodia rutaecarpa, hypericum japonicum, Poria cocos, luffa, radix rehmanniae recen, Sargent gloryvine, Radix Isatidis, the root of large-flowered skullcap, gypsum, is used tumbling-box type medicine-washing machine to clean, and scavenging period is controlled at 3-5 minute, avoids drug effect to run off;
The step of B, demulcen: the traditional Chinese medicinal components that steps A is cleaned up, use water injection type medicine processing device to carry out demulcen operation, demulcen makes the plant cell imbibition of dehydration, for abstraction process creates conditions;
C, above-mentioned component add 10 times of weight amount ethanol, heating and refluxing extraction 3 times, and each 2 hours, No. 3 extracts are merged, decompression recycling ethanol, and to be concentrated into liquor strength be 0.5g crude drug/mL, after suction filtration, when the relative density of filtrate is 20 ℃ 1.08; The large pore resin absorption column that described filtrate flow is 10L through volume, use afterwards deionized water or the distilled water wash-out of 10 times of resin column volumes, use again 95% ethanol elution of 5 times of resin column volumes, collect ethanol eluate, remove alcohol solvent, obtain Chinese medicinal powder, then after 80 order sieve, standby after ultraviolet sterilization;
The step of D, sea cucumber deep processing: fresh and alive sea cucumbers, along belly from first to last complete section open, gill, impurity is cleaned up; Then carry out freeze drying, cryogenic temperature is-20 ~-25 ℃, and vacuum is 5-15Pa, and snap frozen 2-3h puts into pulverizer by the sea cucumber after freeze drying, pulverizes 10-30min, crosses 60 mesh sieves, obtains thick sea cucumber powder; Sea cucumber meal is carried out to ultramicro grinding by airslide disintegrating mill, and time 2-3h, obtains ultra micro sea cucumber powder; Then ultra micro sea cucumber powder is carried out to nanometer pulverizing by high speed shear ultrafine crusher, grinding time is 3-5h;
In container, add pure water, sea cucumber powder after nanometer is pulverized with water with 1: the dissolving of 5-10 mass ratio, obtain sea cucumber milk, take the compound protease of sea cucumber weight 0.3-0.4%, compound protease is the mixture of pepsic bromelain stomach, protease: the mass ratio=2:1 of bromelain, after using pure water that compound protease is dissolved, together with sea cucumber milk, put into enzymatic vessel, standing 1-2min in the microwave environment that is 500-1000w in intensity, carry out the operation of microwave enzymolysis, after enzymolysis completes, by enzymolysis liquid rapidly degree of intensification to 90 ℃ of enzyme 10-30min that go out, complete after the deactivation of enzyme, enzymatic vessel is stopped to heating, enzymolysis liquid is cooled to rapidly to normal temperature, enzymatic vessel purified rinse water, flushing liquor is put into enzymolysis liquid, enzymolysis liquid after cooling is first used to the centrifugal 20min of generic centrifuge, filter, get filtrate, the centrifugal 20min of low temperature ultrahigh speed, filters, and obtains filtrate, by filtrate by nanofiltration with except freshen, residue is crossed 100 mesh sieves, obtains sea cucumber extract,
E, prepare the step of capsule: step C gained Chinese medicinal powder is joined in the sea cucumber extract of step D gained to Chinese medicinal powder: the weight ratio of sea cucumber extract is 1-1.2:1-1.5; After mixing, add additional material, in the pasty state, compression molding, is dried to obtain chewable tablets to the mixture obtaining.
The using method of described sea cucumber nutrient sheet, wherein, comprises the steps:
A, chew: postoperative patient, chewable tablets 1-2 ante cibum every day sheet,
B, soaked: postoperative patient, chewable tablets every day is a slice after meal, the soaked 50ml of a slice.
Object lesson 3
Middle spice: 40 parts, peach kernel, 30 parts of myrrhs, 30 parts, safflower, 30 parts of caulis bambusae in taenians, 20 parts of Exocarpium Citri Rubrums, 20 parts of evodia rutaecarpas, 20 parts of hypericum japonicum, 20 parts, Poria cocos, 20 parts of luffas, 20 parts of radix rehmanniae recens, 20 parts of Sargent gloryvines, 20 parts of Radix Isatidis, 20 parts of the roots of large-flowered skullcap, 20 parts, gypsum,
Basestocks: 400 parts of sea cucumbers;
Additional material: 5 parts of chitins, 15 parts of starch, 8 parts, dextrin, 5 parts, sweet mellow wine, 3 parts of Icing Sugar, 3 parts of microcrystalline celluloses.
During preparation, the step of A, cleaning: by peach kernel, myrrh, safflower, caulis bambusae in taenian, Exocarpium Citri Rubrum, evodia rutaecarpa, hypericum japonicum, Poria cocos, luffa, radix rehmanniae recen, Sargent gloryvine, Radix Isatidis, the root of large-flowered skullcap, gypsum, is used tumbling-box type medicine-washing machine to clean, and scavenging period is controlled at 3-5 minute, avoids drug effect to run off;
The step of B, demulcen: the traditional Chinese medicinal components that steps A is cleaned up, use water injection type medicine processing device to carry out demulcen operation, demulcen makes the plant cell imbibition of dehydration, for abstraction process creates conditions;
C, above-mentioned component add 10 times of weight amount ethanol, heating and refluxing extraction 3 times, and each 2 hours, No. 3 extracts are merged, decompression recycling ethanol, and to be concentrated into liquor strength be 0.5g crude drug/mL, after suction filtration, when the relative density of filtrate is 20 ℃ 1.08; The large pore resin absorption column that described filtrate flow is 10L through volume, use afterwards deionized water or the distilled water wash-out of 10 times of resin column volumes, use again 95% ethanol elution of 5 times of resin column volumes, collect ethanol eluate, remove alcohol solvent, obtain Chinese medicinal powder, then after 80 order sieve, standby after ultraviolet sterilization;
The step of D, sea cucumber deep processing: fresh and alive sea cucumbers, along belly from first to last complete section open, gill, impurity is cleaned up; Then carry out freeze drying, cryogenic temperature is-20 ~-25 ℃, and vacuum is 5-15Pa, and snap frozen 2-3h puts into pulverizer by the sea cucumber after freeze drying, pulverizes 10-30min, crosses 60 mesh sieves, obtains thick sea cucumber powder; Sea cucumber meal is carried out to ultramicro grinding by airslide disintegrating mill, and time 2-3h, obtains ultra micro sea cucumber powder; Then ultra micro sea cucumber powder is carried out to nanometer pulverizing by high speed shear ultrafine crusher, grinding time is 3-5h;
In container, add pure water, sea cucumber powder after nanometer is pulverized with water with 1: the dissolving of 5-10 mass ratio, obtain sea cucumber milk, take the compound protease of sea cucumber weight 0.3-0.4%, compound protease is the mixture of pepsic bromelain stomach, protease: the mass ratio=2:1 of bromelain, after using pure water that compound protease is dissolved, together with sea cucumber milk, put into enzymatic vessel, standing 1-2min in the microwave environment that is 500-1000w in intensity, carry out the operation of microwave enzymolysis, after enzymolysis completes, by enzymolysis liquid rapidly degree of intensification to 90 ℃ of enzyme 10-30min that go out, complete after the deactivation of enzyme, enzymatic vessel is stopped to heating, enzymolysis liquid is cooled to rapidly to normal temperature, enzymatic vessel purified rinse water, flushing liquor is put into enzymolysis liquid, enzymolysis liquid after cooling is first used to the centrifugal 20min of generic centrifuge, filter, get filtrate, the centrifugal 20min of low temperature ultrahigh speed, filters, and obtains filtrate, by filtrate by nanofiltration with except freshen, residue is crossed 100 mesh sieves, obtains sea cucumber extract,
E, prepare the step of capsule: step C gained Chinese medicinal powder is joined in the sea cucumber extract of step D gained to Chinese medicinal powder: the weight ratio of sea cucumber extract is 1-1.2:1-1.5; After mixing, add additional material, in the pasty state, compression molding, is dried to obtain chewable tablets to the mixture obtaining.
The using method of described sea cucumber nutrient sheet, wherein, comprises the steps:
A, chew: postoperative patient, chewable tablets 1-2 ante cibum every day sheet,
B, soaked: postoperative patient, chewable tablets every day is a slice after meal, the soaked 50ml of a slice.
eating effect comparison of the present invention:
50 small white mouses of take are animal used as test, by the long 3mm of rear thigh incised wound of 50 small white mouses, the wound of dark 1mm, respectively smear mercurochrome and wrap gauze, and then every 10 is one group,
First group is the present invention of experimental group feeding,
Second group as a control group 1, do not feed.
The 3rd group as a control group 2, feeding step C gained Chinese medicinal powder.
The 3rd group as a control group 3, feeding contains chitinous capsule and pill.
The 4th group as a control group 4, the sea cucumber extract of feeding step D gained.
The 5th group as a control group 5, direct feeding sea cucumber.
After 3 weeks, wound is carried out to gross specimen observation, biomethanics test, gross specimen observed result: experimental group wound heals completely, falls scab naturally;
Control group 1, not healing.Heal completely compared with 12 days experimental group evenings
Control group 2, healing, does not fall scab substantially; Heal completely compared with 5 days experimental group evenings
Control group 3, healing, does not fall scab substantially; Heal completely compared with 7 days experimental group evenings
To group, according to 4, healing, does not fall scab substantially; Heal completely compared with 6 days experimental group evenings
Control group 5, healing, healed completely compared with 10 days experimental group evenings
Biomethanics test result is as following table:
As can be seen from the above table, the present invention has the effect of quickly-healing wound.
immunity comparison:
Select 10 small white mouse feeding tradition sea cucumber nutrient sheets as a control group,
Select 10 small white mouse feedings the present invention group as a comparison.
Be compared as follows:
Wherein, the absorption of comparative group calcium and mineral matter is fast, and propagation Bifidobacterium, lactic acid bacteria number is many, and the index of blood fat, blood sugar, adjusting cholesterol is low compared with control group.3-5 is placed in dark environment and the environment that is exposed to the sun repeatedly in day, the control group probability of catching an illness is large, so comparative group immunity is strong.
In the present invention, Chinese medicine composition is for the pharmacy mechanism evidence that promotes wound healing:
1, lower the expression of HIF-1 alpha levels, rise VEGF, histocyte can be induced and be produced HIF-1 (hypoxia-inducible factor-1 under hypoxic-ischemic environment, HIF-1, comprise two kinds of HIF-1 α and HIF-1 β), wherein HIF-1 α can modulating vascular endothelial growth factors (vascular endothelial growth factor, VEGF), the expression of endothelin-1, hematopoietin etc., promote formation and the vascular remodeling of new vessels, thereby start wound repair mechanism.By observing benefiting qi and removing blood stasis Chinese medicine, promote the impact of diabetes skin ulcer Rats Exposed To Hypoxia inducible factor-1 and vascular endothelial growth factor, result shows that benefiting qi and removing blood stasis Chinese medicine can be by lowering the expression of HIF-1 α, the expression of rise VEGF, improve ischaemic anaerobic condition, impel angiogenesis, thus wound healing.
2, the acceptor RTK activity in enhancing wound healing is in the process of wound healing, growth factor plays an important role, growth factor is by receptor tyrosine kinase (receptor tyrosine kinase, RTK) mediated cell external stimulus signal, the functions such as the propagation of regulating cell, differentiation.Observe the impact of Chinese medicine on soft-tissue trauma healing receptor tyrosine kinase activity, result shows that Chinese medicine can strengthen the RTK activity in soft-tissue trauma healing.
3, promote the propagation of new capillary vessel, promote granulation tissue growth to improve the regeneration of permeability and the blood vessel of surface of a wound blood vessel, can improve the blood confession of affected part, promote granulation tissue growth, accelerate the immediate union of the surface of a wound.Herbal mixture promotes the experimental study of rabbit skin wound healing, and result shows that this herbal mixture has significant effect in wound healing, can promote wound reconstructing blood vessel, reduces the infiltration of inflammatory cell, accelerates collagenous fibres hyperplasia and forms scar, prevents wound infection.
4, promote rising transforming growth factor-beta 1 (the transforming growth factor-β 1 that TGF-β 1 expresses, TGF-β 1) Main Function is growth and the differentiation that regulates cell, synthetic and the Apoptosis of inducing cell epimatrix, thereby the healing of promotion wound.By the observation to transforming growth factor-beta and wound healing, result shows that TGF-β 1 expresses and raises at early metaphase, to promoting the synthetic collagen of fibroblast, proteoglycans, fiber connexin and integral protein, strengthening migration of epithelial cells and fibroblast synthetic cell epimatrix has key effect, is an importance of its wound healing.
Proportioning of the present invention is simple, prescription collocation rationally, speed of wound healing is reconciled, increased to Promote immunity, be specially: the present invention be take sea cucumber as basestocks, add therein promoting blood circulation and removing blood stasis, hemostasis and pain-relieving, promoting qi circulation and removing obstruction in the collateral, the corresponding traditional Chinese medicinal components of clearing heat and moistening dryness, to improve speed of wound healing, in addition, further add chitin, sea cucumber effect, herbal function are combined with chitin effect, and preparation becomes chewable tablets to be used, and all effect is remarkable in the speed for the treatment of wound for more independent treatment by Chinese herbs, simple sea cucumber tonic or chitin capsule and pill.
Claims (2)
1. a sea cucumber nutrient sheet, is characterized in that, comprises following active component: peach kernel, myrrh, safflower, caulis bambusae in taenian, Exocarpium Citri Rubrum, evodia rutaecarpa, hypericum japonicum, Poria cocos, luffa, radix rehmanniae recen, Sargent gloryvine, Radix Isatidis, the root of large-flowered skullcap, gypsum, sea cucumber; Chitin, starch, dextrin, sweet mellow wine, Icing Sugar, microcrystalline cellulose.
2. as claim, require a using method for sea cucumber nutrient sheet as described in 1, it is characterized in that, comprise the steps:
A, chew: postoperative patient, chewable tablets 1-2 ante cibum every day sheet,
B, soaked: postoperative patient, chewable tablets every day is a slice after meal, the soaked 50ml of a slice.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310492156.1A CN103598622A (en) | 2013-10-20 | 2013-10-20 | Sea cucumber nutrient tablet and application method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310492156.1A CN103598622A (en) | 2013-10-20 | 2013-10-20 | Sea cucumber nutrient tablet and application method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN103598622A true CN103598622A (en) | 2014-02-26 |
Family
ID=50116936
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201310492156.1A Pending CN103598622A (en) | 2013-10-20 | 2013-10-20 | Sea cucumber nutrient tablet and application method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN103598622A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108030004A (en) * | 2017-12-05 | 2018-05-15 | 河北汉唯生物制药有限公司 | A kind of sea cucumber nutrient composition, its preparation method and the food containing it |
-
2013
- 2013-10-20 CN CN201310492156.1A patent/CN103598622A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108030004A (en) * | 2017-12-05 | 2018-05-15 | 河北汉唯生物制药有限公司 | A kind of sea cucumber nutrient composition, its preparation method and the food containing it |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN103610035A (en) | Preparation method for sea cucumber nutritional oral liquid | |
| CN101238893B (en) | High edible fibre chickpea nutritive powder and preparation and application thereof | |
| CN103610072A (en) | Preparation method for blood-sugar-reducing sea cucumber oral liquid | |
| CN103598593A (en) | Manufacturing method of sea cucumber nutrient tablets | |
| CN103598623A (en) | Manufacturing method of sea cucumber tablets | |
| CN103610077A (en) | Sea cucumber capsule | |
| CN103610076A (en) | Preparation method for sea cucumber capsule | |
| CN103585456A (en) | Sea cucumber chewable tablet | |
| CN103599468A (en) | Manufacturing method of sea cucumber tablet for adjusting immunity | |
| CN103598622A (en) | Sea cucumber nutrient tablet and application method thereof | |
| CN103598578A (en) | Sea cucumber chewing tablet and application method thereof | |
| CN103598576A (en) | Manufacturing method of sea cucumber chewing tablet capable of increasing wound healing speed | |
| CN103598625A (en) | Sea cucumber tablet | |
| CN103599469A (en) | Sea cucumber chewing tablet capable of increasing wound healing speed and application method thereof | |
| CN103599366A (en) | Manufacturing method of sea cucumber chewing tablets | |
| CN103610069A (en) | Blood-sugar-reducing sea cucumber oral liquid | |
| CN103610068A (en) | Preparation method for blood-fat-reducing sea cucumber oral liquid | |
| CN103598577A (en) | Sea cucumber nutrient tablet | |
| CN103598575A (en) | Sea cucumber chewing tablet capable of increasing wound healing speed | |
| CN103610116A (en) | Preparation method for sea cucumber nutritional capsule | |
| CN103598624A (en) | Sea cucumber tablet and application method thereof | |
| CN107596277A (en) | A kind of sea cucumber chewable tablet for increasing speed of wound healing | |
| CN103599470A (en) | Sea cucumber tablet for adjusting immunity | |
| CN103610073A (en) | Sea cucumber oral liquid and application method thereof | |
| CN103610070A (en) | Blood-fat-reducing sea cucumber oral liquid and application method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20140226 |
|
| WD01 | Invention patent application deemed withdrawn after publication |