CN103585601B - Veterinary medicine for treating pig diarrhea caused by deficiency-cold in spleen and stomach - Google Patents
Veterinary medicine for treating pig diarrhea caused by deficiency-cold in spleen and stomach Download PDFInfo
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Abstract
The invention discloses a veterinary medicine for treating pig diarrhea caused by deficiency-cold in spleen and stomach. The key points of the technical scheme are as follows: the veterinary medicine is prepared from the following raw materials in parts by weight: 10-15 parts of radix aconiti lateralis preparata, 10-15 parts of dried ginger, 6-10 parts of radix glycyrrhizae preparata, 6-10 parts of fructus evodiae, 10-15 parts of cortex cinnamomi, 10-15 parts of fructus amomi, 7-12 parts of poria cocos, 10-15 parts of radix linderae, 6-10 parts of szechuan lovage rhizome, 6-10 parts of parched rhizoma atractylodis, 6-10 parts of katsumadai seed, 6-10 parts of grassleaf sweelflag rhizome, 6-10 parts of radix curcumae, 6-10 parts of stir-fried malt, 0.5 parts of microecologics, and 0.05 parts of enzymic preparation. The powder size of each raw material is 30-200 meshes. The veterinary medicine is free from toxic and side effects. The processing technology is simple; the production cost is low; the veterinary medicine can effectively reduce the diarrhea rates of piglets and finishing pigs, improve the immunity of swinery, and improve the quality of pork.
Description
Technical field:
The present invention relates to veterinary drug, particularly a kind of veterinary drug for the treatment of Lien Sus domestica insufficiency of stomach cold diarrhea.
Background technology:
China is a large agricultural country, especially an aquaculture big country, and swine rearing amount over 30 years of reforming and opening up to the outside world occupy the first in the world.According to the data of State Statistics Bureau, the annual live pig output of China is at about 6.6 hundred million.Along with the expansion of the scale of raising pigs, integral level had had large increase more in the past, but still there is a lot of problem, be mainly manifested in relevant technology and auxiliary facility is seriously delayed, environmental pollution, epidemic disease is serious, relevant criterion is unsound, production process and intermediate links drive by short-term interests, and its result causes epidemic disease to roll up, and cause the economic loss of tens billion of unit every year.
Wherein diarrhoea is a kind of phenomenon the most common in swinery, is one of main clinic symptoms of Intestinum Sus domestica tract disease, how because of caused by intestinal absorption obstacle, with increased frequency of discharging feces, feces is thin, hemafecia is basic Clinical symptoms syndrome.Diarrhoea be not an independently disease, but caused by many reasons or numerous disease with a kind of facing examine common multiple syndrome.Its reason comprises viral element: as Transmissible gastroenteritis virus, epidemic diarrhea virus, Astrovirus, rotavirus, visible peristalsis visible intestinal peristalsis adenovirus, small reovirus etc.; Bacillary factor: as enteroinvasive E.Coli, enterotoxigenic escherichia coli, Escherichia coli, intestinal adhesion escherichia coli, pasteurella multocida, Salmonella, shigella, vibrio parahaemolytious, staphylococcus aureus, aeromonas hydrophila etc.; Parasitic factor: as coccidiosis, whipworm, ancylostome, Cryptosporidium, Entamoeba histolytica worm, merchant younger brother flagellate, ascarid, strongyloides intestinalis, trichostrongyle, pouch ciliate, pinworm etc.; And non-pathogenic factors, comprise trophic factors shortage, daily ration antigen allergy, stressors, digestive function are not congruent.
At present, for the method that the generation of prevention and corntrol diarrhea of pigs disease is conventional is long-term interpolation antibiotic and some chemicals etc. in feedstuff.But in feedstuff, long-term a large amount of consequence using antibiotic and chemicals to cause is a large amount of generations of Resistant strain, and a large amount of formation of drug residue have a strong impact on the effect of control and prevention of disease, have a strong impact on the quality of pork product.Except epidemic disease, medicine, chemical substance, hormone, heavy metal etc. are day by day serious to the pollution of pork product; Cultivation inefficiency, cultivation integrated cost is higher; Service system is unsound, and monitoring means fall behind; Multiple yard feeding pattern is also deposited, and causes product very different, and animal products safety has become the cardinal task of harm humans health and animal husbandry development.
Summary of the invention:
The object of this invention is to provide a kind of can overcome pig because of long-term excessive use antibiotic cause the generation of endurance strain, avoid medicine residual in pig body after using, strengthen the immunity of pig body, significantly improve the veterinary drug of the treatment Lien Sus domestica insufficiency of stomach cold diarrhea of pork product quality.
Technical scheme of the present invention is, a kind of veterinary drug for the treatment of Lien Sus domestica insufficiency of stomach cold diarrhea, it is characterized in that: Radix Aconiti Lateralis Preparata: 10-15 weight portion, Rhizoma Zingiberis: 10-15 weight portion, Radix Glycyrrhizae Preparata: 6-10 weight portion, Fructus Evodiae: 6-10 weight portion, Cortex Cinnamomi: 10-15 weight portion, Fructus Amomi 10-15 weight portion, Poria: 7-12 weight portion, the Radix Linderae: 10-15 weight portion, Rhizoma Chuanxiong: 6-10 weight portion, Rhizoma Atractylodis (parched): 6-10 weight portion, roud cardamon seed: 6-10 weight portion, Rhizoma Acori Graminei: 6-10 weight portion, Radix Curcumae: 6-10 weight portion, Fructus Hordei Germinatus (parched): 6-10 weight portion, microbial ecological agent: 0.5 weight portion, enzyme preparation: 0.05 weight portion composition.The powder size of described each raw material is 30-200 order.
The present invention has dispelling cold and removing dampness, stomach invigorating of invigorating blood circulation, supporing yang antidiarrheal, warming the spleen whets the appetite, and has adjustment flora simultaneously, and the feature such as have no side effect, and processing technique is simple, production cost is low, effectively reduces the diarrhea rate of piglet and growing and fattening pigs, enhances the immunity of swinery, have adjusted the intestinal microbial population of swinery, effectively prevent generation and antibiotic the remaining in pig body of Resistant strain, improve the product quality of Carnis Sus domestica, reduce environmental pollution.
The present invention simultaneously has the following advantages:
1, meet national basic veterinary drug exploitation industrial policy, meet produce nuisanceless, antibiotic-free remains, the requirement of pollution-free food.Meet the requirement of development scientific and technological enterprises and enhancing Enterprise Innovation Capability.
2, do not produce the ubiquitous drug resistance problems of prior art.
3, because the present invention is made up of natural plants and a small amount of microbial ecological agent and enzyme preparation, there is not toxicity problem itself with regard to medicine, therefore can not produce toxic side effects to animal, this point obtains the proof of correlation test.
4, the results showed, medicine character of the present invention and efficacy stability and storage tolerance, be also applicable to transport that is long-distance and adverse circumstances, this use for medicine is very favourable beyond doubt.
Detailed description of the invention:
Describe embodiment in detail,
Embodiment 1
Get Radix Aconiti Lateralis Preparata: 15kg, Rhizoma Zingiberis: 15kg, Radix Glycyrrhizae Preparata: 10kg, Fructus Evodiae: 10kg, Cortex Cinnamomi: 15kg, Fructus Amomi 15kg, Poria: 10kg, the Radix Linderae: 15kg, Rhizoma Chuanxiong: 10kg, Rhizoma Atractylodis (parched): 10kg, roud cardamon seed: 10kg, Rhizoma Acori Graminei: 10kg, Radix Curcumae: 10kg, Fructus Hordei Germinatus (parched): 10kg, microbial ecological agent: 0.5kg, enzyme preparation: 0.05kg.
Described microbial ecological agent is that the pig tailored version that Shandong Baolai-leelai Bio-engineering Co., Ltd. produces produces enzyme probiotics, obviously can improve intestine microenvironment, suppress the growth and breeding of the harmful bacteria such as Escherichia coli, Salmonella, regulate the colony balance in Intestinum Sus domestica road, promote the growth of the probioticss such as bacillus bifidus, improve the immune function of pig, set up the benign cycle of pig body health, reduce the death caused because of diarrhea of pigs.
The Hylotelephium erythrostictum (Miq.) H.Ohba prestige 2X powder that described enzyme preparation is produced for building bright industry (Zhuhai) company limited, be made up of cellulase, α-amylase, xylanase, protease, amylopectase, 1,4 beta-glucanase, pectase, corresponding protein, starch and non-starch polysaccharides(nsp) can be hydrolyzed to aminoacid, oligopeptide, oligosaccharide, oligosaccharide and monosaccharide etc. by enzyme hydrolysis effect, promote pig digesting and assimilating respective egg white matter and polysaccharide.During preparation, existing being added in pulverizer by each composition Chinese herbal medicine is processed into 60 object powder, sieves, after add microbial ecological agent: 0.5kg, enzyme preparation: 0.05kg, then mix homogeneously, packaging, saves backup.
The corresponding test of invention formulation adopts various dose treatment through being accredited as the piglet pujos blancos test of natural occurrence, and selects ciprofloxacin to be positive drug control group.Observe the present invention to the therapeutical effect of piglet pujos blancos, to inquire into the science that it applies in Swine Production.Experiment Chinese medicine divides high, normal, basic three dosage i.e. 2.0%, 1.5%, 1.0% ratio to add in feedstuff, is used in conjunction 5 days.Result shows, invention formulation is treated for the piglet pujos blancos of natural infection, and the cure rate of low dose group is 67.5%, and total effective rate is 84.5%; The cure rate of senior middle school's two dosage groups is 87.5%, and total effective rate is 94.5%; Mortality rate is only 1.9%, suitable with ciprofloxacin treatment group, and difference extremely significantly (P<0.01) compared with infection matched group.
From result of the test, invention formulation has dispelling cold and removing dampness, stomach invigorating of invigorating blood circulation, supporing yang antidiarrheal, and warming the spleen whets the appetite, and has adjustment flora simultaneously, and the function such as have no side effect.Do not find that this medicine has untoward reaction facing to examine in process of the test.High, normal, basic dosage all has good therapeutic effect to piglet pujos blancos.Senior middle school's dosage group therapeutic effect no significant difference compared with ciprofloxacin group, low dose group curative effect lower than senior middle school's dosage group, senior middle school's dosage group equal no significant difference in mortality rate, cure rate and total effective rate.Should according to circumstances and treatment cost, suggestion is faced and is examined middle application with middle dosage 1.5% as well, is used in conjunction about 5 days.Test medication about 3 days epidemic situations are controlled, and sickness rate declines, but now should continue medication to 5-7 days with consolidate curative effect, prevent epidemic situation from recurring.
Acute toxicity test:
Adopt horn method white mice acute toxinology experiment, select 20 healthy Kun Ming mice, be divided into 2 groups at random, often organize 10, test group every gavages 0.5g(and be equivalent to 21.5g/kg body weight every day) Chinese herbs, matched group every gavages the normal saline of same dosage every day.Observe 7d, finally it all cutd open and kill, observe internal organs without observing ANOMALOUS VARIATIONS, Liver and kidney spleen histological observation is also no abnormal, and hemogram and serum GPT activity compare without significant difference with matched group.Show in the toxicity test result of pig being carried out to body animal, invention formulation is in whole 7d feeding experiment process, and test pig well-grown, has no any toxic and side effects, consistent with test mice result, and the LD of this preparation is described
50be far longer than 21.5g/kg body weight, by acute toxinology experiment classification, this preparation belongs to non-poisonous material, is safe and reliable.
Subacute toxicity test:
For understanding the subacute toxicity situation of invention formulation, carry out this test at the enterprising row of mice, in experimental period, palatability difference is caused because drug dose is excessive and except affecting and searching for food except high dose group, respectively group mice appetite, behavior and feces are all normal for all the other, physically well develop, without any poisoning symptom, the hemogram of each group and serum GPT activity are all within normal range.Doubly to feed 30d by facing the 3-4 examining dosage, have no any toxic and side effects, it is very safe for illustrating that invention formulation faces the dosage of examining medication.
This product is according to listing terms of packing, and in temperature 40 DEG C ± 2 DEG C, deposit 3 months under relative humidity 75% ± 5% condition, quality is without significant change, and in temperature 25 DEG C ± 2 DEG C, deposit 22 months under relative humidity 60% ± 10% condition, quality is without significant change.Above-mentioned result of the test shows, this product under prescribed conditions storage quality is stablized, can long storage periods.
During use, add according to 0.5-2% ratio in pig feed, or oral by drinking-water according to Chinese medical discrimination result, and play dispelling cold and removing dampness, stomach invigorating of invigorating blood circulation, supporing yang antidiarrheal, warming the spleen whets the appetite, and has the function of adjustment flora simultaneously.
Embodiment 2,
Get Radix Aconiti Lateralis Preparata: 10kg, Rhizoma Zingiberis: 10kg, Radix Glycyrrhizae Preparata: 6kg, Fructus Evodiae: 6kg, Cortex Cinnamomi: 10kg, Fructus Amomi 10kg, Poria: 10kg, the Radix Linderae: 15kg, Rhizoma Chuanxiong: 10kg, Rhizoma Atractylodis (parched): 10kg, roud cardamon seed: 10kg, Rhizoma Acori Graminei: 10kg, Radix Curcumae: 10kg, Fructus Hordei Germinatus (parched): 10kg, microbial ecological agent: 0.5kg, enzyme preparation: 0.05kg.
Described microbial ecological agent is that the pig tailored version that Shandong Baolai-leelai Bio-engineering Co., Ltd. produces produces enzyme probiotics, obviously can improve intestine microenvironment, suppress the growth and breeding of the harmful bacteria such as Escherichia coli, Salmonella, regulate the colony balance in Intestinum Sus domestica road, promote the growth of the probioticss such as bacillus bifidus, improve the immune function of pig, set up the benign cycle of pig body health, reduce the death caused because of diarrhea of pigs.
The Hylotelephium erythrostictum (Miq.) H.Ohba prestige 2X powder that described enzyme preparation is produced for building bright industry (Zhuhai) company limited, be made up of cellulase, α-amylase, xylanase, protease, amylopectase, 1,4 beta-glucanase, pectase, corresponding protein, starch and non-starch polysaccharides(nsp) can be hydrolyzed to aminoacid, oligopeptide, oligosaccharide, oligosaccharide and monosaccharide etc. by enzyme hydrolysis effect, promote pig digesting and assimilating respective egg white matter and polysaccharide.During preparation, existing being added in pulverizer by each composition Chinese herbal medicine is processed into 60 object powder, sieves, after add microbial ecological agent: 0.5kg, enzyme preparation: 0.05kg, then mix homogeneously, packaging, saves backup.
During preparation, existing being added in pulverizer by each composition Chinese herbal medicine is processed into 30 object powder, sieves, after add microbial ecological agent: 0.5kg, enzyme preparation: 0.05kg, then mix homogeneously, packaging, saves backup.
The corresponding test of invention formulation adopts various dose treatment through being accredited as the piglet pujos blancos test of natural occurrence, and selects ciprofloxacin to be positive drug control group.Observe the present invention to the therapeutical effect of piglet pujos blancos, to inquire into the science that it applies in Swine Production.Experiment Chinese medicine divides high, normal, basic three dosage i.e. 2.0%, 1.5%, 1.0% ratio to add in feedstuff, is used in conjunction 5 days.Result shows, the present invention falls apart and to treat for the piglet pujos blancos of natural infection, and the cure rate of low dose group is 78%, and total effective rate is 86%; The cure rate of senior middle school's two dosage groups is 90%, and total effective rate is 95%; Mortality rate is only 2%, suitable with ciprofloxacin treatment group, and difference extremely significantly (P<0.01) compared with infection matched group.
From result of the test, invention formulation has dispelling cold and removing dampness, stomach invigorating of invigorating blood circulation, supporing yang antidiarrheal, and warming the spleen whets the appetite, and has adjustment flora simultaneously, and the function such as have no side effect.Do not find that this medicine has untoward reaction facing to examine in process of the test.High, normal, basic dosage all has good therapeutic effect to piglet pujos blancos.Senior middle school's dosage group therapeutic effect no significant difference compared with ciprofloxacin group, low dose group curative effect lower than senior middle school's dosage group, senior middle school's dosage group equal no significant difference in mortality rate, cure rate and total effective rate.Should according to circumstances and treatment cost, suggestion is faced and is examined middle application with middle dosage 1.5% as well, is used in conjunction about 5 days.Test medication about 3 days epidemic situations are controlled, and sickness rate declines, but now should continue medication to 5-7 days with consolidate curative effect, prevent epidemic situation from recurring.
Acute toxicity test:
Adopt horn method white mice acute toxinology experiment, select 20 healthy Kun Ming mice, be divided into 2 groups at random, often organize 10, test group every gavages 0.5g(and be equivalent to 21.5g/kg body weight every day) Chinese herbs, matched group every gavages the normal saline of same dosage every day.Observe 7d, finally it all cutd open and kill, observe internal organs without observing ANOMALOUS VARIATIONS, Liver and kidney spleen histological observation is also no abnormal, and hemogram and serum GPT activity compare without significant difference with matched group.Show in the toxicity test result of pig being carried out to body animal, invention formulation is in whole 7d feeding experiment process, and test pig well-grown, has no any toxic and side effects, consistent with test mice result, and the LD of this preparation is described
50be far longer than 21.5g/kg body weight, by acute toxinology experiment classification, this preparation belongs to non-poisonous material, is safe and reliable.
Subacute toxicity test:
For understanding the subacute toxicity situation of invention formulation, carry out this test at the enterprising row of mice, in experimental period, palatability difference is caused because drug dose is excessive and except affecting and searching for food except high dose group, respectively group mice appetite, behavior and feces are all normal for all the other, physically well develop, without any poisoning symptom, the hemogram of each group and serum GPT activity are all within normal range.Doubly to feed 30d by facing the 3-4 examining dosage, have no any toxic and side effects, it is very safe for illustrating that invention formulation faces the dosage of examining medication.
This product is according to listing terms of packing, and in temperature 40 DEG C ± 2 DEG C, deposit 3 months under relative humidity 75% ± 5% condition, quality is without significant change, and in temperature 25 DEG C ± 2 DEG C, deposit 22 months under relative humidity 60% ± 10% condition, quality is without significant change.Above-mentioned result of the test shows, this product under prescribed conditions storage quality is stablized, can long storage periods.
During use, add according to 0.5-2% ratio in pig feed, or oral by drinking-water according to Chinese medical discrimination result, and play dispelling cold and removing dampness, stomach invigorating of invigorating blood circulation, supporing yang antidiarrheal, warming the spleen whets the appetite, and has the function of adjustment flora simultaneously.
Embodiment 3
Get Radix Aconiti Lateralis Preparata: 12kg, Rhizoma Zingiberis: 12kg, Radix Glycyrrhizae Preparata: 6kg, Fructus Evodiae: 6kg, Cortex Cinnamomi: 12kg, Fructus Amomi 10kg, Poria: 10kg, the Radix Linderae: 12kg, Rhizoma Chuanxiong: 10kg, Rhizoma Atractylodis (parched): 12kg, roud cardamon seed: 10kg, Rhizoma Acori Graminei: 10kg, Radix Curcumae: 10kg, Fructus Hordei Germinatus (parched): 10kg, microbial ecological agent: 0.5kg, enzyme preparation: 0.05kg.
Described microbial ecological agent is that the pig tailored version that Shandong Baolai-leelai Bio-engineering Co., Ltd. produces produces enzyme probiotics, obviously can improve intestine microenvironment, suppress the growth and breeding of the harmful bacteria such as Escherichia coli, Salmonella, regulate the colony balance in Intestinum Sus domestica road, promote the growth of the probioticss such as bacillus bifidus, improve the immune function of pig, set up the benign cycle of pig body health, reduce the death caused because of diarrhea of pigs.
The Hylotelephium erythrostictum (Miq.) H.Ohba prestige 2X powder that described enzyme preparation is produced for building bright industry (Zhuhai) company limited, be made up of cellulase, α-amylase, xylanase, protease, amylopectase, 1,4 beta-glucanase, pectase, corresponding protein, starch and non-starch polysaccharides(nsp) can be hydrolyzed to aminoacid, oligopeptide, oligosaccharide, oligosaccharide and monosaccharide etc. by enzyme hydrolysis effect, promote pig digesting and assimilating respective egg white matter and polysaccharide.During preparation, existing being added in pulverizer by each composition Chinese herbal medicine is processed into 60 object powder, sieves, after add microbial ecological agent: 0.5kg, enzyme preparation: 0.05kg, then mix homogeneously, packaging, saves backup.
During preparation, existing being added in pulverizer by each composition Chinese herbal medicine is processed into 60 object powder, sieves, after add microbial ecological agent: 0.5kg, enzyme preparation: 0.05kg, then mix homogeneously, packaging, saves backup.
The corresponding test of invention formulation adopts various dose treatment through being accredited as the piglet pujos blancos test of natural occurrence, and selects ciprofloxacin to be positive drug control group.Observe the present invention to the therapeutical effect of piglet pujos blancos, the science test Chinese medicine applied in Swine Production to inquire into it divides high, normal, basic three dosage i.e. 2.0%, 1.5%, 1.0% ratio to add in feedstuff, is used in conjunction 5 days.Result shows, invention formulation is treated for the piglet pujos blancos of natural infection, and the cure rate of low dose group is 78%, and total effective rate is 86%; The cure rate of senior middle school's two dosage groups is 90%, and total effective rate is 95%; Mortality rate is only 2%, suitable with ciprofloxacin treatment group, and difference extremely significantly (P<0.01) compared with infection matched group.
From result of the test, invention formulation has dispelling cold and removing dampness, stomach invigorating of invigorating blood circulation, supporing yang antidiarrheal, and warming the spleen whets the appetite, and has adjustment flora simultaneously, and the function such as have no side effect.Do not find that this medicine has untoward reaction facing to examine in process of the test.High, normal, basic dosage all has good therapeutic effect to piglet pujos blancos.Senior middle school's dosage group therapeutic effect no significant difference compared with ciprofloxacin group, low dose group curative effect lower than senior middle school's dosage group, senior middle school's dosage group equal no significant difference in mortality rate, cure rate and total effective rate.Should according to circumstances and treatment cost, suggestion is faced and is examined middle application with middle dosage 1.5% as well, is used in conjunction about 5 days.Test medication about 3 days epidemic situations are controlled, and sickness rate declines, but now should continue medication to 5-7 days with consolidate curative effect, prevent epidemic situation from recurring.
Acute toxicity test:
Adopt horn method white mice acute toxinology experiment, select 20 healthy Kun Ming mice, be divided into 2 groups at random, often organize 10, test group every gavages 0.5g(and be equivalent to 21.5g/kg body weight every day) Chinese herbs, matched group every gavages the normal saline of same dosage every day.Observe 7d, finally it all cutd open and kill, observe internal organs without observing ANOMALOUS VARIATIONS, Liver and kidney spleen histological observation is also no abnormal, and hemogram and serum GPT activity compare without significant difference with matched group.Show in the toxicity test result of pig being carried out to body animal, preparation of the present invention is in whole 7d feeding experiment process, and test pig well-grown, has no any toxic and side effects, consistent with test mice result, and the LD of this preparation is described
50be far longer than 21.5g/kg body weight, by acute toxinology experiment classification, this preparation belongs to non-poisonous material, is safe and reliable.
Subacute toxicity test:
For understanding the subacute toxicity situation of invention formulation, carry out this test at the enterprising row of mice, in experimental period, palatability difference is caused because drug dose is excessive and except affecting and searching for food except high dose group, respectively group mice appetite, behavior and feces are all normal for all the other, physically well develop, without any poisoning symptom, the hemogram of each group and serum GPT activity are all within normal range.Doubly to feed 30d by facing the 3-4 examining dosage, have no any toxic and side effects, it is very safe for illustrating that preparation of the present invention faces the dosage of examining medication.
This product is according to listing terms of packing, and in temperature 40 DEG C ± 2 DEG C, deposit 3 months under relative humidity 75% ± 5% condition, quality is without significant change, and in temperature 25 DEG C ± 2 DEG C, deposit 22 months under relative humidity 60% ± 10% condition, quality is without significant change.Above-mentioned result of the test shows, this product under prescribed conditions storage quality is stablized, can long storage periods.
During use, add according to 0.5-2% ratio in pig feed, or oral by drinking-water according to Chinese medical discrimination result, and play dispelling cold and removing dampness, stomach invigorating of invigorating blood circulation, supporing yang antidiarrheal, warming the spleen whets the appetite, and has the function of adjustment flora simultaneously.
Case below for curing:
1) great Bei agriculture pig farm, Xinxiang, Henan to have the piglet group about 593 35-45 ages in days show down in spirits summer, arrange white scattered paste shape feces, feed intake declines, dead about 15 of day, in feedstuff, add veterinary drug of the present invention according to 1.5%, start after three days to increase material, diarrhoea alleviates, after one week, the swinery mental status, feed intake and feces recover normal, and cure rate reaches 93.4%(553/593), effective percentage reaches 97.0% (576/593).
2) pig farm, Xinxiang, Henan Hui Xianmeng village has the piglet group spirit of 191 36 ages in days depressed spring, and feed intake reduces, and feces is thin, become pitchy, have bad smell, dead about 6 of day, 1.5% veterinary drug of the present invention is added in feedstuff, after three days, feed intake starts to increase, and diarrhoea alleviates, dead minimizing, occur without dead pig in swinery after one week, feed intake recovers normal, and cure rate reaches 93.7%(179/191), effective percentage reaches 97.4% (186/191).
3) pig farm, Tanghe County, Henan 694 46 age in days left and right ablactational baby pig group down in spirits in spring, white dysentery, feed intake falls sharply, dead about 16 of day, cuts open inspection pathological changes at intestinal, is full of a large amount of milky Calx sample material in performance enteric cavity.Treatment: add 1.5% veterinary drug of the present invention in feedstuff, start after three days to increase material, death reduces to 2-3 head every day, fragmentary death is only had in swinery after one week, feed intake recovers normal, and cure rate reaches 93.5%(651/694), effective percentage reaches 96.8% (672/694).
4) there is the piglet group down in spirits of 157 45 ages in days on pig farm, the Henan Hui Xianmeng village, arrange white scattered paste shape feces, feed intake declines, dead about 5 of day, 1.5% veterinary drug of the present invention is added in feedstuff, start after three days to increase material, diarrhoea alleviates, dead minimizing, occur without dead pig in swinery after one week, feed intake recovers normal, and cure rate reaches 93.7%(179/191), effective percentage reaches 97.4% (186/191).
5) Huixian, Henan Duan Tun pig farm raising scale about 300,2009 so far according to 1.0% ratio add medicine of the present invention since the well-grown of swinery, occur without large epidemic disease, long-term Incidence of Diarrhea controls at below 5-7%, the quality of Carnis Sus domestica is good, receives the favorable comment of periphery consumer.
6) Henan Science and Technology College Lao Jiao veterinary hospital sees and treat patients diarrhoeal diseases pig 2113, its main manifestations tired mind, and by hair slightly disorderly, proscopiny, draw white or pitchy loose stool, appetite is poor, under in nutrition.Treatment: add veterinary drug of the present invention according to 1.5% in feedstuff, start after three days to increase material, spirit is clearly better, and appetite increases, and diarrhoea alleviates, and after one week, pig body weight increases, and feed intake recovers normal, and cure rate reaches 87.6%, and effective percentage reaches 95.5%.
As can be seen from above test situation, the present invention has significant curative effect to control piglet pujos blancos class diarrhoeal diseases, its preventive effect also clearly, has the good prospect that it is applied, and will promote the sound development of non-nuisance and noresidue green"meat product processing industry.
Claims (2)
1. treat the veterinary drug of Lien Sus domestica insufficiency of stomach cold diarrhea for one kind, it is characterized in that: Radix Aconiti Lateralis Preparata: 10-15 weight portion, Rhizoma Zingiberis: 10-15 weight portion, Radix Glycyrrhizae Preparata: 6-10 weight portion, Fructus Evodiae: 6-10 weight portion, Cortex Cinnamomi: 10-15 weight portion, Fructus Amomi 10-15 weight portion, Poria: 7-12 weight portion, the Radix Linderae: 10-15 weight portion, Rhizoma Chuanxiong: 6-10 weight portion, Rhizoma Atractylodis (parched): 6-10 weight portion, roud cardamon seed: 6-10 weight portion, Rhizoma Acori Graminei: 6-10 weight portion, Radix Curcumae: 6-10 weight portion, Fructus Hordei Germinatus (parched): 6-10 weight portion, microbial ecological agent: 0.5 weight portion, enzyme preparation: 0.05 weight portion composition.
2. a kind of veterinary drug for the treatment of Lien Sus domestica insufficiency of stomach cold diarrhea as claimed in claim 1, is characterized in that: the powder size of described each raw material is 30-200 order.
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| CN104146182B (en) * | 2014-08-28 | 2015-09-02 | 成都双胞胎饲料有限公司 | A kind of biology feed additive preventing and treating grice diarrhoea |
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| CN1368292A (en) * | 2001-02-06 | 2002-09-11 | 杨孟君 | Nano medicing 'Wenzhong Zhixie' and its preparing process |
| CN100525828C (en) * | 2007-01-30 | 2009-08-12 | 赵希容 | Oral preparation for regulating spleen-stomach deficiency-cold type diarrhea and its preparation method |
| CN102187956B (en) * | 2011-06-22 | 2012-12-19 | 毕景阳 | Non-antibiotic biological compound premix |
| CN103041081B (en) * | 2013-01-16 | 2015-01-07 | 成都中医药大学 | Medicament composition for treating spleen-insufficiency diarrhea type irritable bowel syndrome and preparation method thereof |
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