CN102488767A - Sticktight-containing compound composition for treating bacterial diarrhoea of livestock and poultry - Google Patents
Sticktight-containing compound composition for treating bacterial diarrhoea of livestock and poultry Download PDFInfo
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- HOBWAPHTEJGALG-JKCMADFCSA-N [(1r,5s)-8-methyl-8-azoniabicyclo[3.2.1]octan-3-yl] 3-hydroxy-2-phenylpropanoate;sulfate Chemical compound [O-]S([O-])(=O)=O.C([C@H]1CC[C@@H](C2)[NH+]1C)C2OC(=O)C(CO)C1=CC=CC=C1.C([C@H]1CC[C@@H](C2)[NH+]1C)C2OC(=O)C(CO)C1=CC=CC=C1 HOBWAPHTEJGALG-JKCMADFCSA-N 0.000 claims abstract description 13
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention discloses a sticktight-containing compound composition for treating bacterial diarrhoea of livestock and poultry. The compound composition is characterized by comprising raw materials of, by weight, 3-15 parts of lactic acid ciprofloxacin, 0.02-0.2 part of atropine sulfate, 20-70 parts of sticktight, 20-40 parts of rhizoma atractylodis, 8-20 parts of dark plum and 5-10 parts of myrobalan. The compound composition is prepared by mixing well the raw materials according to the proportion. An addition into an animal fodder is 0.1%-0.8%. The composition of the invention can kill bacteria rapidly and alleviate diarrhoea symptom caused by bacteria rapidly, has good protective effect on intestinal tract and overcomes disadvantages of a simple western medicine, such as long curative effect, weak curative effect, slow symptom alleviation and disadvantage of slow effect performance of a simple traditional Chinese medicine; besides, usage of the composition has low medicine cost and creates high benefit for farmers. The composition can be prepared into a powder, an oral liquid, a particulate agent and a tablet.
Description
Technical field
The present invention relates to a kind of treatment fowl bacterial diarrheal compound.
Background technology
Along with Developing of Animal Industry, culture the expansion of scale, antibiotic random use and arbitrarily adding in the spreading unchecked of raiser's medication, the breeding process causes antibacterial that medicine has been produced stronger drug resistance.In addition along with the interpolation of antimicrobial drug in the feedstuff; The intravital intestinal microbial population of poultry has also suffered bigger destruction; And cultivated the harmful bacterium of a large amount of drug resistance; Therefore fowl bacterial diarrhoea often takes place in aquaculture, has had a strong impact on the speed of growth and the price of deed of animal, diarrhoea severe patient even cause dehydration dead; This disease has caused bigger economic loss to the raiser, and people press for curative effect better, relief of symptoms, the medicine that has better protective effect especially can treat the livestock and poultry diarrhea that drug tolerant bacteria causes to intestinal are treated fast.
Adopt antimicrobial drug to treat to fowl bacterial diarrhoea people at present more; The effect of antimicrobial drug only is antibiotic, but the symptom of pathological changes such as the intestinal mucosa that causes for antibacterial comes off, intestinal walls is poor, intestinal absorption ability and serious dehydration is powerless.In antimicrobial drug when treatment, be prone to produce drug resistance in addition, therapeutic effect is undesirable, administration time is long, even diarrhoea seriously causes dehydration death.Therefore; Need suddenly to wait a kind of such product in the actual production; This product can be very fast kill pathogenic bacteria, can the damage that pathogenic bacteria is caused body well be repaired and relieving diarrhea symptom fast again, can comparatively fast cure livestock and poultry diarrhea faster like this; It is dead with dehydration to be unlikely to influence the speed of growth, for the raiser creates higher economic benefit.
Summary of the invention
The purpose of this invention is to provide a kind of treatment fowl bacterial diarrheal compound; Said composition is killing bacteria faster; Can alleviate faster bacterial symptom of diarrhea again simultaneously; Intestinal there is the better protect effect, has overcome western medicine weak curative effect, curative effect length, relief of symptoms shortcoming slowly.
In order to satisfy the urgent demand of social production, the present invention realizes above-mentioned purpose through following technical scheme:
A kind of treatment fowl bacterial diarrheal compound is characterized in that the material composition of this complex and weight portion ratio thereof are:
3～15 parts of ciprofloxacin lactate, 0.02～0.2 part of atropine sulfate, 20～70 parts of Herba Bidentis Bipinnatae, 20～40 parts of Rhizoma Atractylodis, 8～20 parts of Fructus Mumes, 5～10 parts of Fructus Chebulaes.
Compound method is:
Get each material composition by said weight part ratio, mixing is processed compound.
The addition of compound in animal feed is: 1 ‰～8 ‰.
Each medicine has following effect among the present invention:
1, ciprofloxacin lactate is a FQNS, belongs to the broad spectrum antibiotic of chemosynthesis, and this medicine belongs to the desirable antibacterials that price is lower, drug resistance is less relatively in all antimicrobial drugs in treatment diarrhoea at present; The sensitivity of this medicine is that applicant's process is separated livestock and poultry diarrhea case 480 examples, and through the drug sensitive test analysis, this medicine of antimicrobial drug of equal price is the most responsive medicine.In the present composition, this medicine can be killed cause of disease fast, removes endogenous cause of ill, has reached the simple effect that can not suppress pathogenic bacteria with Chinese medicine fast;
2, atropine sulfate belongs to cholinolytic class medicine, can combine with the M cholinoceptor, removes the muscarine-like effect of acetylcholine and other cholinomimetic.These article use in the diarrhoea case through the spasm of removing smooth muscle, inhibition glandular secretion and are used for reducing intestinal peristalsis promoting, and the relieving diarrhea symptom is avoided the appearance of poultry dehydration phenomenon as far as possible.Atropine also has excited respiratory center, makes effects such as palpitating speed, the appearance that can complementaryly slow down the animal shock symptom in addition;
3, Fructus Mume has the astringing intestine to stop diarrhea of astringing the lung, promoting the production of body fluid to quench thirst, anthelmintic action, especially relieving diarrhea with astringents; Fructus Mume is better to chronic diarrhea chronic dysentery effect action effect, and the alleviation to symptom of diarrhea in prescription of these article has better curative effect, with the Fructus Chebulae be that mutual reinforcement between is a usefulness; The two is usefulness also, better the antidiarrheal dysentery relieving;
4, Fructus Chebulae has relieving diarrhea with astringents, astringing lung-QI and relieving cough effect, and especially to the chronic diarrhea chronic dysentery, the damp and hot symptom effect of intestine and small intestine is preferable;
5, Rhizoma Atractylodis, gas is fragrant hot strong, and bitter warm nature is dry; Can disperse again and induce sweat, have the dehumidifying function of invigorating spleen, The spleen has the function to transport and transform nutrients; It is wet to like dry evil, and livestock and poultry diarrhea generally is that turbid damp is stranded spleen, causes transporting and transforming function of the spleen and stomach mistake department to cause stomachache to be had loose bowels; Therefore in this compositions with the hot sweetening treatment of Rhizoma Atractylodis wet with dampness and spleen invigorating, the function of recovering that The spleen has the function to transport and transform nutrients helps antidiarrheal and recovery appetite;
6, Herba Bidentis Bipinnatae is widely distributed in the torrid zone and temperate zone area, is traditional herbal medicine, and very easily gather than horn of plenty in the source, and this medicine is bitter, flat, nontoxic.Have heat-clearing and toxic substances removing, dissipating blood stasis for subsidence of swelling.Have antibacterial, hepatoprotective effect, cure mainly diseases such as malaria, diarrhoea, dysentery, hepatitis, acute nephritis, stomachache, especially ulcerative enteritis, ulcer property diarrhoea are had better curative effect.Among the people in China, Herba Bidentis Bipinnatae is through being usually used in treating infantile diarrhea, acute gastroenteritis and bacillary dysentery, high blood pressure disease.
The compositions that the present invention makes, better to the effect of fowl bacterial diarrhoea curative effect, and drug cost is lower, can be the raiser and creates higher benefit.
The specific embodiment:
The raw material of Chinese medicine Herba Bidentis Bipinnatae of this compound, Rhizoma Atractylodis, Fructus Mume, Fructus Chebulae become basic material through after pulverizing 60 mesh sieves, with pulverous ciprofloxacin lactate, atropine sulfate by weight ratio get each raw material and put into the blender mixing and get final product.Experiment below in practice following raw materials by weight percent having been done:
3～5 parts of ciprofloxacin lactate, 0.02～0.2 part of atropine sulfate, 50～70 parts of Herba Bidentis Bipinnatae, 10～30 parts of Rhizoma Atractylodis, 8～15 parts of Fructus Mumes, 5～10 parts of Fructus Chebulaes; Addition in animal and fowl fodder is 5～8 ‰;
4～10 parts of ciprofloxacin lactate, 0.02～0.2 part of atropine sulfate, 40～60 parts of Herba Bidentis Bipinnatae, 20～40 parts of Rhizoma Atractylodis, 10～20 parts of Fructus Mumes, 8～15 parts of Fructus Chebulaes; Addition in animal and fowl fodder is 3～6 ‰;
8～15 parts of ciprofloxacin lactate, 0.02～0.2 part of atropine sulfate, 35～50 parts of Herba Bidentis Bipinnatae, 20～40 parts of Rhizoma Atractylodis, 7～15 parts of Fructus Mumes, 6～9 parts of Fructus Chebulaes; Addition in animal and fowl fodder is 1～5 ‰;
7 parts of ciprofloxacin lactate, 0.1 part of atropine sulfate, 37 parts of Herba Bidentis Bipinnatae, 30 parts of Rhizoma Atractylodis, 16 parts of Fructus Mumes, 10 parts of Fructus Chebulaes; Addition in animal and fowl fodder is 3 ‰.
With the compound that each material rate group draws, be applied to zoopery and find, in the material rate scope of technical scheme respectively to organize compound close to the influence that animal produces.So, below the compound preparation that draws with above-mentioned each material rate group of compositions general designation do the embodiment explanation.
Embodiment 1
Compound is observed the efficacy experiment of Pullorum Disease disease:
Clinical symptoms: Guangxi Yulin chicken house, 10 age in days broiler, the chicken crowd draws white feces, and the part chicken is stuck with paste anus by feces, and indivedual chickens sound all the time, and occur fragmentary dead.
Cut open the inspection pathological changes: the chicken that dies of illness dehydration is more serious, and visible eyes sink, and toe is withered, hepatomegaly, hyperemia, but the downright bad point of the liver adularescent of part chicken.
Laboratory diagnosis: get pathologic liver and dye sheet, Gram, microscopically is observed, the gram negative bacilli of red color visible; Tentatively be judged as the Salmonella disease.Through the distinctive coagulation experiment of Salmonella, judge that it is the Salmonella disease that chicken infects.
Therapeutic regimen: morbidity chicken crowd administration in two batches, first uses above-mentioned compound, and by 5 ‰ administrations, logotype 5 days is used the ofloxacin powder for second batch, by 5 ‰ administrations, logotype 5 days.
The result of use feedback: after 2 days, sick chicken is no longer drawn white feces with this compound, and feed intake rises, and dead chicken no longer occurs, continues to use 2 days, and chicken the crowd be almost recovered; But use a collection of chicken of folk prescription ofloxacin, medication is after 2 days, and chicken crowd majority is healthy basically, but still draws white feces individually, continues to use 2 days, gets well basically, but drug withdrawal is after 5 days, and recurrence appears in the chicken crowd.Be superior to folk prescription it is thus clear that contain the compound curative effect of Herba Bidentis Bipinnatae.
Embodiment 2
Compound is observed the efficacy experiment of diarrhea of weaned piglets:
Clinical symptoms: the pig farm, Nanning, 36 age in days ablactational baby pig, this swinery is after wean is turn-taked; Begin diarrhoea to occur, draw watery stools, feces contains indigested feedstuff; Pig is material feeding but is exactly not long that indivedual serious diarrhea of pigs dehydrations are dead, symptoms of emesis do not occur; The raiser uses multiple medicine, and ideal effect does not all appear in treatment.
Cut open the inspection pathological changes: the pig that dies of illness dehydration is more serious, and visible eyes sink, and it is poor to cut open inspection back Intestinum Sus domestica wall, especially small intestinal rear end and colon position, and intestinal mucosa comes off, intestinal wall hyperemia, hemorrhage.
Therapeutic regimen: the administration in two batches of morbidity swinery, first uses above-mentioned compound, and by 5 ‰ administrations, logotype 5 days is used the ofloxacin powder for second batch, by 5 ‰ administrations, logotype 5 days.
The result of use feedback: after 3 days, swinery is no longer drawn watery stools with this compound, and feces is shaped, and no longer contains feedstuff in the feces, continues to use 2 days the swinery recovery from illness; But use a collection of pig of folk prescription ofloxacin, medication is after 3 days, and swinery is healthy basically, but still draws pasty state feces individually, continues to use 2 days, gets well basically, but drug withdrawal is after 6 days, and recurrence appears in swinery.It is thus clear that contain the compound of Herba Bidentis Bipinnatae the swinery curative effect is superior to folk prescription ofloxacin medicine.
Embodiment 3
Compound is to the meat-type duck diarrheal observation of curative effect of 20 ages in days:
Clinical symptoms: duck field, Nanning, 20 age in days meat-type duck, the duck crowd draws watery stools, and tangible indigested feedstuff is arranged in the feces.A duck crowd material feeding is not but long, and the serious duck appearance foot gradually of suffering from diarrhoea individually is soft slowly dead.
Cut open the inspection pathological changes: the duck that dies of illness dehydration is more serious, and indivedual ducks are still very big, duck liver enlargement, hyperemia, and adularescent film on the liver of part duck, air bag is muddy, and tentative diagnosis is escherichia coli or duck oromeningitis.
Therapeutic regimen: morbidity duck crowd administration in two batches, first uses above-mentioned compound, and by 5 ‰ administrations, logotype 5 days is used the ofloxacin powder for second batch, by 5 ‰ administrations, logotype 5 days.
The result of use feedback: after 2 days, sick duck is no longer drawn watery stools with this compound, and feces is shaped, and dead duck no longer occurs, continues to use 3 days, and duck the crowd be almost recovered; But use a collection of duck of folk prescription ofloxacin, medication is after 2 days, and duck crowd DeGrain much still draws watery stools; Contain indigested feedstuff, continue to use 3 days, some improvement a little, but not good thorough; Rare watery stools still occurs, and the raiser can't drug withdrawal to this batch duck, have to use compound instead, continues to use 2 days; Just be almost recovered, re-use 1 day, feces all transfers to normally.It is thus clear that contain the compound of Herba Bidentis Bipinnatae duck diarrheal curative effect is superior to folk prescription.
Claims (7)
1. one kind contains Herba Bidentis Bipinnatae treatment fowl bacterial diarrheal compound, it is characterized in that the material composition of this complex and weight portion ratio thereof are:
3～15 parts of ciprofloxacin lactate, 0.02～0.2 part of atropine sulfate, 20～70 parts of Herba Bidentis Bipinnatae, 20～40 parts of Rhizoma Atractylodis, 8～20 parts of Fructus Mumes, 5～10 parts of Fructus Chebulaes;
Compound method is:
Get each material composition in said weight portion ratio, mixing is processed compound.
2. compositions according to claim 1, its dosage form can be powder, tablet, oral liquid, granule.
3. compositions according to claim 1 is characterized in that:
The addition of described compositions in animal and fowl fodder is: 1 ‰～8 ‰.
4. compound according to claim 1 is characterized in that the material composition of said composition and weight portion ratio thereof are:
3～5 parts of ciprofloxacin lactate, 0.02～0.2 part of atropine sulfate, 50～70 parts of Herba Bidentis Bipinnatae, 10～30 parts of Rhizoma Atractylodis, 8～15 parts of Fructus Mumes, 5～10 parts of Fructus Chebulaes; Addition in animal and fowl fodder is 5～8 ‰.
5. compound according to claim 1 is characterized in that the material composition of said composition and weight portion ratio thereof are:
4～10 parts of ciprofloxacin lactate, 0.02～0.2 part of atropine sulfate, 40～60 parts of Herba Bidentis Bipinnatae, 20～40 parts of Rhizoma Atractylodis, 10～20 parts of Fructus Mumes, 8～15 parts of Fructus Chebulaes; Addition in animal and fowl fodder is 3～6 ‰.
6. compound according to claim 1 is characterized in that the material composition of said composition and weight portion ratio thereof are:
8～15 parts of ciprofloxacin lactate, 0.02～0.2 part of atropine sulfate, 35～50 parts of Herba Bidentis Bipinnatae, 20～40 parts of Rhizoma Atractylodis, 7～15 parts of Fructus Mumes, 6～9 parts of Fructus Chebulaes; Addition in animal and fowl fodder is 1～5 ‰.
7. compound according to claim 1 is characterized in that the material composition of said composition and weight portion ratio thereof are:
7 parts of ciprofloxacin lactate, 0.1 part of atropine sulfate, 37 parts of Herba Bidentis Bipinnatae, 30 parts of Rhizoma Atractylodis, 16 parts of Fructus Mumes, 10 parts of Fructus Chebulaes; Addition in animal and fowl fodder is 3 ‰.
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| CN103721240A (en) * | 2013-12-20 | 2014-04-16 | 湖南泰谷生物科技股份有限公司 | Compound formulation for treating bacterial infection of digestive tract of livestock and poultry and preparation method of compound formulation |
| CN105309842A (en) * | 2015-11-24 | 2016-02-10 | 广州聚注专利研发有限公司 | Fish feed additive and preparation method thereof |
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| CN102488767B (en) | 2013-12-25 |
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Effective date of registration: 20160513 Address after: 530100 the Guangxi Zhuang Autonomous Region Nanning Yilin Industrial Zone No. B-9 (Wuming) Patentee after: GUANGXI NANNING TAOYUAN VETERINARY DRUG FACTORY Address before: 530104 the Guangxi Zhuang Autonomous Region Nanning Yilin Industrial Zone No. B-9 Patentee before: Zhang Chaohui |
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Denomination of invention: The invention relates to a compound composition containing Bidens bipinnata for treating bacterial diarrhea of livestock and poultry Effective date of registration: 20210111 Granted publication date: 20131225 Pledgee: Guangxi Beibu Gulf Bank Limited by Share Ltd. small business financial services center Pledgor: GUANGXI NANNING TAOYUAN VETERINARY DRUG FACTORY Registration number: Y2021450000002 |
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