CN103565537A - Mouse irradiation disc fixing device - Google Patents
Mouse irradiation disc fixing device Download PDFInfo
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- CN103565537A CN103565537A CN201210256742.1A CN201210256742A CN103565537A CN 103565537 A CN103565537 A CN 103565537A CN 201210256742 A CN201210256742 A CN 201210256742A CN 103565537 A CN103565537 A CN 103565537A
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- fixing device
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- disc fixing
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Abstract
The invention discloses a mouse irradiation disc fixing device. The mouse irradiation disc fixing device comprises a base disc (1) and a top cover (4) arranged on the base disc, the base disc (1) is of a concentric circle structure formed by a round outer edge and a round inner edge, a plurality of partition boards (9) are arranged between the round outer edge and the round inner edge to divide the base disc (1) into mouse cells of the same size, the round outer edge of the base disc (1) is evenly provided with a plurality of raised clamps (11) with adjustable height, the top cover (4) is provided with an elliptical mouse passing hole (8), the position of the top cover, which is adjacent to the mouse passing hole (8), is provided with a push-pull type baffle (6) which plays a sealing role. Due to the fact that the height of the raised clamps can be adjusted to enable the mouse cells to have gaps, the mouse irradiation disc fixing device can guarantee that mice can breathe normally during experiments, and improves the accuracy of irradiation dose; can meet the requirement of simultaneously irradiating one group or a plurality of groups of animals to improve experiment efficiency and to reduce experiment costs. Besides, main body components of the mouse irradiation disc fixing device are easy to disassemble, so that cleaning is facilitated.
Description
Technical field
The present invention relates to a kind of mice irradiation fixture of using in experiment, what be specifically related to is the disc fixing device that mice cobalt-60 irradiation or other irradiation bomb are used in experimentation.
Background technology
In the research process of radiation biological effect, often need to carry out mice irradiation experiment.While carrying out mice irradiation experiment, conventionally the mice of same group or same exposure dose need to be put into a certain smaller container, then accept irradiation.
But, because container is generally all larger, mice can be freely movable inside, cannot be completely fixed, and during irradiation square being inversely proportional to of the absorbed dose of mice and distance, so mice plays very large effect here apart from the distance of radioactive source, if mice can not be relatively fixing, can not guarantee that mice is accepted uniform exposure dose on the same group, have a strong impact on the reliability of experimental result.
At present, mouse fixing for irradiation experiment also has some Patents, a kind of mouse fixing as Chinese utility model patent CN201977959U bulletin, comprises base, is fixedly arranged on draw-in groove, dress Mus pipe on described base, and draw-in groove matches with dress Mus pipe; Dress Mus pipe clamp is fixed in described bayonet socket; The inner tube of described dress Mus pipe can be held mice; Wherein, be provided with Mus pipe lid in described dress Mus pipe, Mus pipe lid can slide front and back in dress Mus pipe; The size of the small space that described dress Mus pipe forms with described Mus pipe lid can be covered the different of position in dress Mus pipe by described Mus pipe and adjusts, and described Mus pipe lid is fastened card in hole and fastened and be fixed in described dress Mus pipe by being interspersed in the card filling on Mus pipe.The mice of this utility model, for packing into after Mus pipe, is fixed in side by side on base, and source mostly is point source in reality is irradiated, and this utility model mouse fixing still can not guarantee that mice on the same group accepts the exposure dose of homogeneous completely.And the fixing of every mice all need to regulate back and forth card to fasten, more time-consuming.
Summary of the invention
For existing deficiency in prior art, the object of the invention is to provide a kind of fixture for mice irradiation experiment, and while meeting experiment, animal can receive uniform exposure dose on the same group, guarantees experimental result accuracy and reliability.
The present invention solves the problems of the technologies described above adopted technical scheme as described below:
A kind of mice irradiation disc fixing device, comprise chassis and be arranged on the top cover on chassis, it is characterized in that: described chassis serve as reasons circular outer and circular in along the concentric structure forming, in circular outer and circle, between edge, some dividing plates are set, chassis is divided into equal-sized Mus interval, some padded cards are evenly set, described padded card Height Adjustable on the circular outer on chassis.
Further, described padded card is " U " shape structure, is stuck on the outer on chassis, and is screwed.
Further, the center on described chassis arranges fixed screw, and the center of top cover arranges the screw hole corresponding with fixed screw, and fixed screw is fixed together chassis and top cover through screw hole by pad and clamp nut.
Further, on described top cover, be provided with the oval Mus hole of boring, in the adjacent position of boring Mus hole, the baffle plate sealing be set.
Further, described baffle plate is push-pull structure, and one end of baffle plate links together by rivet and top cover.
Further, on described top cover, be provided with for rotating the handle of top cover.
Further, the bottom at each Mus interval is provided with for distinguishing the label of different mices.
Further, the quantity at described Mus interval is 12-16.
Further again, described chassis and top cover adopt transparent organic glass to make.
Beneficial effect of the present invention is as follows: the present invention by arranging some dividing plates on concentric circular chassis, and some height-adjustable padded cards are set in outer, chassis, while making mice illuminated, be that concentric circular is arranged, position is also consistent, has guaranteed the homogeneity of radioactive dose; By Height Adjustable padded card is set, make to leave gap between concentric circular chassis and top cover, can guarantee the eupnea of mice in experimentation; Marking pen labelling can be used in each bottom, Mus interval on concentric circular chassis, can guarantee that the different groups to irradiate simultaneously, the mice of sex do not produce and obscure; And the present invention can determine the space size of fixture inside once by adjusting the height of padded card, make it to match with the build of mice, fixed, can improve the accuracy of exposure dose; The present invention once can be simultaneously fixing 12-16 mice, when can meet one or more groups animal, irradiate, can improve conventional efficient, reduce experimental cost; Main element of the present invention is quick detachable in addition, convenient cleaning.
Accompanying drawing explanation
Fig. 1 is the STRUCTURE DECOMPOSITION figure of mice irradiation disc fixing device;
Fig. 2 is the front view of mice irradiation disc fixing device;
Fig. 3 is the side view of mice irradiation disc fixing device;
Fig. 4 is the top view of mice irradiation disc fixing device;
Fig. 5 is the top view of the top cover of mice irradiation disc fixing device;
Fig. 6 is the top view on the chassis of mice irradiation disc fixing device;
The specific embodiment
In the research process of the biological effects of radiation, often will utilize cobalt-60 or other irradiation bomb to carry out various dose irradiation to mice, but the accuracy of exposure dose directly have influence on the reliability of experimental result.The present invention is divided into 12-16 mice interval by concentric circular chassis with dividing plate, the small space that mice interval and top cover form can hold mice, make mice freely activity therein, padded card can guarantee to retain certain gap in the middle of concentric circular chassis and top cover, and the size that can highly come adjusting play by adjusting it, so that the mice that fixedly build differs in size, and make mouse breathing unobstructed.The present invention can realize disposablely to be irradiated 12-16 mice, and because chassis is concentric design, can realize the uniform irradiation to mice, can improve the illumination efficiency to mice, guarantees accuracy and the reliability of experimental result.
Below in conjunction with the drawings and specific embodiments, present invention is described.
Mice irradiation disc fixing device of the present invention, as shown in Fig. 1-6, comprise chassis 1 and be arranged on the top cover 4 on chassis, chassis 1 serve as reasons circular outer and circular in along the concentric structure forming, in circular outer and circle, between edge, some dividing plates 9 are set, chassis 1 is divided into equal-sized Mus interval 10, and the quantity at described Mus interval 10 can be 12-16, and the bottom at each Mus interval 10 can be provided for distinguishing the label of different mices.Some padded cards 11 are evenly set on the circular outer on chassis 1, padded card 11 Height Adjustable, by regulating the height of padded card 11 can determine the gap size between concentric circular chassis 1 and top cover 4, to adjust mice irradiation disc fixing device, hold the space size of mice.
The center on chassis 1 arranges fixed screw 12, and the center of top cover 4 arranges the screw hole 5 corresponding with fixed screw 12, and fixed screw 12 is fixed together chassis 1 and top cover 4 through screw hole 5 by pad 3 and clamp nut 2.On top cover 4, be provided with the oval Mus hole 8 of boring, in the adjacent position of boring Mus hole 8, the baffle plate 6 sealing be set, baffle plate 6 can be push-pull structure, and one end of baffle plate 6 links together by rivet and top cover 4.On top cover 4, be also provided with for rotating the handle 7 of top cover 4, the quantity of handle 7 can be two.
The chassis 1 of mice irradiation disc fixing device of the present invention and top cover 4 adopt transparent organic glass to make.
In one embodiment, mice irradiation disc fixing device for mice cobalt-60 irradiation experiment, comprise concentric circular chassis 1, top cover 4, the material of concentric circular chassis 1, top cover 4 is normal transparent lucite, between two concentric circulars on concentric circular chassis 1, with dividing plate 9, be divided into equal-sized Mus interval 10, the available marking pen in bottom at Mus interval 10 is indicated animal number, to distinguish different mices.On the outer on concentric circular chassis 1, be fixed with some padded cards 11, can be by regulating it highly to regulate the gap size between concentric circular chassis 1 and top cover 4, thereby can adjust the size of Mus clearance space, to hold and the fixing mice of different volumes, and guarantee that mouse breathing is unobstructed.Padded card 11 of the present invention is " U " shape structure, is stuck on the outer on chassis 1, and fixes by screw.Unscrew the screw on padded card 11, the relative position of the padded card of up-down adjustment 11 and outer, chassis, screwing screw then, can regulate the height of padded card.
There is a fixed screw 12 at 1 center, chassis, fixed screw 12 is through the screw hole 5 arranging in the middle of top cover 4, concentric circular chassis 1 and top cover 4 are linked together, the top of fixed screw 12 is fixing with pad 3 and clamp nut 2, the pad 3 topmost arranging by fixed screw and fixed screw and clamp nut 2, the degree of tightness in the time of can regulating top cover 4 to rotate.Top cover 4 is provided with the oval Mus hole 8 of boring in position corresponding to Mus interval 10 with concentric circular chassis 1, the size in hole guarantees that mice can enter in the Mus interval 10 on concentric circular chassis 1, on brill Mus hole 8, being provided with can be for the baffle plate 6 of push-and-pull switch, one end of baffle plate 6 links together by rivet and top cover, and baffle plate 6 can be also other known features.The both sides of boring Mus hole 8 are fixed with two handles 7, can rotate top cover 4 by stirring handle 7.
Preparatory work of experiment process of the present invention is as follows: according to the size of mice individuality, regulate the height of padded card 11, regulate fixed screw 12 clamp nut 2 above, make top cover 4 rotation degrees of tightness suitable, brill Mus hole 8 by mice by top cover 4 tops enters in the Mus interval 10 on concentric circular chassis 1, stir the handle 7 on top cover 4, rotate top cover 4, make to bore Mus hole 8 and aim at next Mus interval 10, then put into next mice, continue operation like this, until mice is also put at last Mus interval, stir the baffle plate 6 that bores Mus hole 8, last mice is fixed, can carry out the irradiation experiment of mice.
The present invention is by some dividing plates are set on concentric circular chassis, and some height-adjustable padded cards are set in outer, chassis, is that concentric circular is arranged while making mice illuminated, and position is also consistent, has guaranteed the homogeneity of radioactive dose; By Height Adjustable padded card is set, make to leave gap between concentric circular chassis and top cover, can guarantee the eupnea of mice in experimentation; Marking pen labelling can be used in each bottom, Mus interval on concentric circular chassis, can guarantee that the different groups to irradiate simultaneously, the mice of sex do not produce and obscure; And the present invention can determine the space size of fixture inside once by adjusting the height of padded card, make it to match with the build of mice, fixed, can improve the accuracy of exposure dose; The present invention once can be simultaneously fixing 12-16 mice, when can meet one or more groups animal, irradiate, can improve conventional efficient, reduce experimental cost; Main element of the present invention is quick detachable in addition, convenient cleaning.
It should be noted that; above-mentioned specific embodiment is only exemplary; under above-mentioned instruction of the present invention, those skilled in the art can carry out various improvement and distortion on the basis of above-described embodiment, and these improvement or distortion all drop in protection scope of the present invention.It will be understood by those skilled in the art that specific descriptions are above in order to explain object of the present invention, not for limiting the present invention.Protection scope of the present invention is limited by claim and equivalent thereof.
Claims (9)
1. a mice irradiation disc fixing device, comprise chassis (1) and be arranged on the top cover (4) on chassis, it is characterized in that: described chassis (1) serve as reasons circular outer and circular in along the concentric structure forming, in circular outer and circle, between edge, some dividing plates (9) are set, chassis (1) is divided into equal-sized Mus interval (10), some padded cards (11) are evenly set, described padded card (11) Height Adjustable on the circular outer on chassis (1).
2. a kind of mice irradiation disc fixing device as claimed in claim 1, is characterized in that: described padded card (11) is " U " shape structure, is stuck on the outer of chassis (1), and is screwed.
3. a kind of mice irradiation disc fixing device as claimed in claim 2, it is characterized in that: the center of described chassis (1) arranges fixed screw (12), the center of top cover (4) arranges the screw hole (5) corresponding with fixed screw (12), and fixed screw (12) is fixed together chassis (1) and top cover (4) through screw hole (5) by pad (3) and clamp nut (2).
4. a kind of mice irradiation disc fixing device as claimed in claim 3, is characterized in that: on described top cover (4), be provided with the oval Mus hole (8) of boring, in the adjacent position of boring Mus hole (8), the baffle plate (6) sealing be set.
5. a kind of mice irradiation disc fixing device as claimed in claim 4, is characterized in that: described baffle plate (6) is push-pull structure, and one end of baffle plate (6) links together by rivet and top cover (4).
6. a kind of mice irradiation disc fixing device as claimed in claim 5, is characterized in that: on described top cover (4), be provided with the handle (7) for rotating top cover (4).
7. a kind of mice irradiation disc fixing device as claimed in claim 6, is characterized in that: the bottom at each Mus interval (10) is provided with for distinguishing the label of different mices.
8. a kind of mice irradiation disc fixing device as described in one of claim 1 to 7, is characterized in that: the quantity at described Mus interval (10) is 12-16.
9. a kind of mice irradiation disc fixing device as claimed in claim 8, is characterized in that: described chassis (1) and top cover (4) adopt transparent organic glass to make.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210256742.1A CN103565537A (en) | 2012-07-23 | 2012-07-23 | Mouse irradiation disc fixing device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210256742.1A CN103565537A (en) | 2012-07-23 | 2012-07-23 | Mouse irradiation disc fixing device |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN103565537A true CN103565537A (en) | 2014-02-12 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201210256742.1A Pending CN103565537A (en) | 2012-07-23 | 2012-07-23 | Mouse irradiation disc fixing device |
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| CN (1) | CN103565537A (en) |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105527416A (en) * | 2016-01-07 | 2016-04-27 | 徐州医学院 | Multichannel induction box for measuring dosage of anaesthetic sucked by small animals |
| CN110074891A (en) * | 2018-01-25 | 2019-08-02 | 中国辐射防护研究院 | Irradiation test rat fixing device |
| CN110522531A (en) * | 2019-09-03 | 2019-12-03 | 河南中医药大学 | A kind of retaining frame device of Brain Radiation Injury model mice experiment |
| CN112285141A (en) * | 2020-10-21 | 2021-01-29 | 中国核动力研究设计院 | Preparation method of irradiated reactor structural material SEM sample and sample box |
| WO2022105619A1 (en) * | 2020-11-23 | 2022-05-27 | 南京中硼联康医疗科技有限公司 | Animal irradiation system and irradiation fixing apparatus thereof |
| CN115607860A (en) * | 2022-12-15 | 2023-01-17 | 首都医科大学宣武医院 | Device and method for establishing carotid artery stenosis mouse model after radiotherapy |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2005261460A (en) * | 2004-03-16 | 2005-09-29 | Teijin Pharma Ltd | Animal fixing base |
| CN101167667A (en) * | 2007-11-21 | 2008-04-30 | 山东省肿瘤防治研究院 | Laboratory mouse fixed case |
| CN201977959U (en) * | 2011-03-04 | 2011-09-21 | 苏州大学 | Mice fixing device for irradiation experiment |
| CN201987699U (en) * | 2011-03-04 | 2011-09-28 | 苏州大学 | Fixing device for rat irradiation experiment |
| CN202015429U (en) * | 2011-03-04 | 2011-10-26 | 苏州大学 | Device for local irradiation on tumor-bearing mouse |
-
2012
- 2012-07-23 CN CN201210256742.1A patent/CN103565537A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2005261460A (en) * | 2004-03-16 | 2005-09-29 | Teijin Pharma Ltd | Animal fixing base |
| CN101167667A (en) * | 2007-11-21 | 2008-04-30 | 山东省肿瘤防治研究院 | Laboratory mouse fixed case |
| CN201977959U (en) * | 2011-03-04 | 2011-09-21 | 苏州大学 | Mice fixing device for irradiation experiment |
| CN201987699U (en) * | 2011-03-04 | 2011-09-28 | 苏州大学 | Fixing device for rat irradiation experiment |
| CN202015429U (en) * | 2011-03-04 | 2011-10-26 | 苏州大学 | Device for local irradiation on tumor-bearing mouse |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105527416A (en) * | 2016-01-07 | 2016-04-27 | 徐州医学院 | Multichannel induction box for measuring dosage of anaesthetic sucked by small animals |
| CN110074891A (en) * | 2018-01-25 | 2019-08-02 | 中国辐射防护研究院 | Irradiation test rat fixing device |
| CN110522531A (en) * | 2019-09-03 | 2019-12-03 | 河南中医药大学 | A kind of retaining frame device of Brain Radiation Injury model mice experiment |
| CN110522531B (en) * | 2019-09-03 | 2022-03-25 | 河南中医药大学 | Protective frame device for radioactive brain injury model mouse experiment |
| CN112285141A (en) * | 2020-10-21 | 2021-01-29 | 中国核动力研究设计院 | Preparation method of irradiated reactor structural material SEM sample and sample box |
| WO2022105619A1 (en) * | 2020-11-23 | 2022-05-27 | 南京中硼联康医疗科技有限公司 | Animal irradiation system and irradiation fixing apparatus thereof |
| CN115607860A (en) * | 2022-12-15 | 2023-01-17 | 首都医科大学宣武医院 | Device and method for establishing carotid artery stenosis mouse model after radiotherapy |
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Application publication date: 20140212 |
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