CN103081816A - Point source irradiating method and tool for chronic irradiation of animals in batch experiments - Google Patents
Point source irradiating method and tool for chronic irradiation of animals in batch experiments Download PDFInfo
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- CN103081816A CN103081816A CN2011103475032A CN201110347503A CN103081816A CN 103081816 A CN103081816 A CN 103081816A CN 2011103475032 A CN2011103475032 A CN 2011103475032A CN 201110347503 A CN201110347503 A CN 201110347503A CN 103081816 A CN103081816 A CN 103081816A
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Abstract
The invention relates to the field of radiation biological effect research of whole body irradiation, in particular to a point source irradiating method and tool for chronic irradiation of animals in batch experiments. Animals are placed in an annular cage and can move relatively free in the cage, simultaneously, a radioactive source is arranged at the center position of the annular cage for irradiating the animals in the cage for regular time, and the animals in different positions of the cage can receive irradiation of equal dosage rate. The point source irradiating method and tool solves the problem demanding prompt solution in chronic low-dosage irradiation experiments and enables experiment results to be accurate and reasonable.
Description
Technical field
The present invention relates to whole body is subjected to be specifically related to chronic point source illumination method and the instrument that is subjected to photograph of a kind of batch experiment animal according to biological effects of radiation research field.
Background technology
The biological effects of radiation are radiation proof Basics of Biology, and its achievement in research has important theory significance and using value in the evaluation of the formulation of radiation protection limit value and Radioprotective Effect.In biological effects of radiation research, radiation damage and biological effect are closely-related with the radioactive dose of research object, but in concrete research process, owing to can not directly with artificial irradiation object, adopting cell line, human peripheric venous blood and laboratory animal to carry out correlative study.
Development along with radiation protection technique, only have and just may occur heavy dose under accident or case of emergency and shone, under normal circumstances, the radiation irradiation that the employee exposed to radiation accepts is the irradiation of low dosage long-term chronic substantially, therefore, in recent years, the research of low dose radiation biological effect is one of emphasis of international biological effects of radiation research always.Owing to being subjected at the chronic low dosage of integral body according in situation, body has certain self-regeneration function, the multiple body functions such as immune system, signal transducting system and humoral system all can participate in the repair process of radiation damage, therefore, be subjected to the isolated experiment result of photograph can not reflect truly that integral body is subjected to according to the biological effects of radiation in situation based on cell line or peripheric venous blood, it is the chronic Main Means that is subjected to according to biological effect of research low dosage that integral body is subjected to according to zoopery.
Integral body in the past is subjected to according in the zoopery process, is subjected to can accept the whole body uniform irradiation according to animal for making, and adopts the method for geometrical clamp.To be subjected to fix according to animal head, tail by geometrical clamp, with the laboratory animal side over against radioactive source, take place, animal axis exposure dose as whole-body dose, take radioactive source as the center of circle, annular is put geometrical clamp, due to operate miss, is difficult to ensure the radioactive dose rate of card different azimuth animal; And due to the restriction of geometrical clamp, be subjected to the photograph size of animal limited around what radioactive source was put.And due to metabolism group, stress physical and chemical index etc. closely related with organism physiology and the state of mind, be subjected to limited according to animal activity after, can affect the expression of these indexs.How in to the laboratory animal irradiation process, make that be subjected to can be relatively freely movable according to animal, can make again many laboratory animal accept simultaneously even isodose rate and be subjected to photograph, be to need the major issue that solves in chronic low dose exposure zoopery.
Summary of the invention
The object of the invention is to the defective for prior art, provide a kind of batch experiment animal chronic point source illumination method and the instrument that is subjected to photograph, can guarantee that laboratory animal is relatively freely movable, can make again the irradiation of the even isodose rate of animals received.
Technical scheme of the present invention is as follows: a kind of chronic point source illumination method that is subjected to photograph of batch experiment animal, and the method is installed in animal in the cage tool of annular, makes animal activity relatively freely in the cage tool; Simultaneously, radioactive source is arranged on the home position of annular cage tool, the animal in the cage tool is carried out the irradiation of stipulated time, make animal different azimuth in the cage tool can both receive the isodose rate irradiation.
Further, the chronic point source illumination method that is subjected to photograph of batch experiment animal as above, wherein, described annular cage tool is spliced by the semicircle cage tool of two formed objects, and the two ends of semicircle cage tool are provided with the opening of getting laboratory animal for dress.
The chronic point source illumination instrument that is subjected to photograph of a kind of batch experiment animal is the loop configuration take radioactive source as the center of circle that two or more circular arc cage tools form, and the two ends of each circular arc cage tool are provided with the opening of getting laboratory animal for dress.
Further, the chronic point source illumination instrument that is subjected to photograph of batch experiment animal as above is comprised of the semicircle cage tool of two formed objects, and each semicircle cage tool comprises upper and lower base plate and inside and outside baffle plate, and the both ends open place of semicircle cage tool is provided with closure plate.
Further, the chronic point source illumination instrument that is subjected to photograph of batch experiment animal as above, wherein, the both sides of the edge of described upper and lower base plate are respectively equipped with draw-in groove, insert respectively in the fluting of upper and lower base plate after inside and outside baffle plate bending, and are adhesively fixed.
Further, the chronic point source illumination instrument that is subjected to photograph of batch experiment animal as above, wherein, the two ends of described upper plate slightly are shorter than lower shoe, are respectively equipped be used to the draw-in groove that pulls and pushes closure plate in the inboard, two ends of inside and outside baffle plate.
Further, the chronic point source illumination instrument that is subjected to photograph of batch experiment animal as above wherein, is equipped with ventilation hole on the upper and lower base plate of semicircle cage tool and inside and outside baffle plate.
Further, the chronic point source illumination instrument that is subjected to photograph of batch experiment animal as above, wherein, described cage tool adopts the lucite material; Bonding by acetone between inside and outside baffle plate and upper and lower base plate.
Beneficial effect of the present invention is as follows: point source illumination instrument provided by the present invention both can guarantee that the batch experiment animal was relatively freely movable, can make again animals received arrive the irradiation of even isodose rate, solved problem demanding prompt solution in chronic low dose exposure zoopery, made experimental result more accurately rationally.
Description of drawings
Fig. 1 is the structural representation of semicircle cage tool in embodiment;
Fig. 2 is the end view of Fig. 1.
Embodiment
Present invention is described below in conjunction with the drawings and specific embodiments.
The present invention has set up can be used in and has made the batch experiment animal guarantee relatively freely activity, can accept simultaneously again point source illumination method and the instrument of even isodose rate irradiation, for the animal irradiation experiment in research low dose radiation biological effect provides the isodose rate chronic exposure that illuminating method and instrument are provided.
Can keep relatively freely movable for guaranteeing to be subjected to according to animal in irradiation process, can not adopt the way of geometrical clamp, should adopt the cage tool, and the animal activity space can not be excessive and affect the radioactive dose accuracy; For guaranteeing to shine with batch being subjected to be subject to simultaneously isodose rate according to animal, should adopt the annular illuminating method take radioactive source as the center of circle; Be the alpha ray shield avoiding causing due to cage tool Effect of Materials and scattering etc., need to adopt low density material processing cage tool.
The chronic point source illumination method that is subjected to photograph of batch experiment animal provided by the present invention is that animal is installed in the cage tool of annular, makes animal activity relatively freely in the cage tool; Simultaneously, radioactive source is arranged on the home position of annular cage tool, the animal in the cage tool is carried out the irradiation of stipulated time, make animal different azimuth in the cage tool can both receive the isodose rate irradiation.Concrete radioactive source choose and arranging of irradiation time all can be with reference to existing geometrical clamp experimental technique, the present invention does not have special restrictive condition to this.
Batch experiment animal provided by the present invention is chronic, and to be subjected to the point source illumination instrument of photograph be the loop configuration take radioactive source as the center of circle that two or more circular arc cage tools form, and the two ends of each circular arc cage tool are provided with the opening of getting laboratory animal for dress.In general, the cage tool integral body after combination is annular and gets final product, and specifically is comprised of several circular arcs unit not have strict restriction, and those skilled in the art can be as required and the condition self manufacture.As a kind of better embodiment, the point source illumination instrument is comprised of the semicircle cage tool of two formed objects, and certainly, it is also feasible being comprised of the circular arc cage tool more than three.
Below, be combined as example with the semicircle cage tool of two formed objects and be specifically described.
As shown in Figure 1, 2, each semicircle cage tool comprises upper and lower base plate 1,2 and inside and outside baffle plate 3,4, and the both ends open place of semicircle cage tool is provided with closure plate 5.Upper and lower base plate 1,2 both sides of the edge are respectively equipped with draw-in groove, insert respectively after inside and outside baffle plate 3,4 bendings in upper and lower base plate 1,2 fluting, and are adhesively fixed.The two ends of upper plate 1 slightly are shorter than lower shoe 2, are respectively equipped be used to the draw-in groove that pulls and pushes closure plate 5 in inside and outside baffle plate 3,4 inboard, two ends.Be equipped with ventilation hole 6 on upper and lower base plate and inside and outside baffle plate.
The present invention adopts lucite (polymethyl methacrylate, PMMA) be raw material, adopt the bonding method of draw-in groove+acetone, make two semicircle cage tools, when implementing irradiation, laboratory animal is packed into after two semicircle cage tools, it is assembled into an annular irradiation instrument take source positions as round dot.
Two semicircle cage tool both ends opens are furnished with the plug-in closure plate, and the dress of being convenient to laboratory animal is got; Cage tool internal diameter can be slightly larger than animal bodies diameter used according to the customization of laboratory animal kind, and can realize being subjected to not only can be relatively freely movable in the cage tool according to animal, can guarantee that also animal whole body radioactive dose error is in allowed band; During use, it is spliced into annular irradiation instrument, can realizes the irradiation of different azimuth animals received isodose rate.
The present embodiment take greater than laboratory animal health diameter 2cm as semicircle cage tool internal diameter, cage tool cross section is square; Adopt the conditions such as exposure dose rate according to radioactive source activity, plan, take radioactive source apart from cage tool internal diameter central point as radial design and process the cage tool.With lucite (polymethyl methacrylate, PMMA) sheet material is raw material, the upper and lower bottom plate of the semicircle cage tool of cutting, upper plate slightly is shorter than lower shoe; According to the inside and outside baffle plate of cage tool girth cutting; Process the draw-in groove that adapts with Weir Plate Thickness on cage tool base plate; Inside and outside baffle plate is crooked and insert in the base plate draw-in groove, adopt acetone bonding; Cage tool both ends open place, baffle plate inboard process and pull and push draw-in groove, the shutoff after the laboratory animal that is used for packing into; Open the equidistant ventilation hole (namely shown plum blossom hole in figure, evenly distribute) of cut-off footpath 1cm in cage tool surrounding.
It should be noted that; above-mentioned specific embodiment is only exemplary; under above-mentioned instruction of the present invention, those skilled in the art can carry out various improvement and distortion on the basis of above-described embodiment, and these improvement or distortion drop in protection scope of the present invention.It will be understood by those skilled in the art that top specific descriptions just in order to explain purpose of the present invention, is not for restriction the present invention.Protection scope of the present invention is limited by claim and equivalent thereof.
Claims (8)
1. chronic point source illumination method that is subjected to photograph of batch experiment animal, it is characterized in that: the method is installed in animal in the cage tool of annular, makes the animal can be movable relatively freely in the cage tool; Simultaneously, radioactive source is arranged on the home position of annular cage tool, the animal in the cage tool is carried out the irradiation of stipulated time, make animal different azimuth in the cage tool can both receive the isodose rate irradiation.
2. the chronic point source illumination method that is subjected to photograph of batch experiment animal as claimed in claim 1, it is characterized in that: described annular cage tool is spliced by the semicircle cage tool of two formed objects, and the two ends of semicircle cage tool are provided with the opening of getting laboratory animal for dress.
3. chronic point source illumination instrument that is subjected to photograph of batch experiment animal, it is characterized in that: be the loop configuration take radioactive source as the center of circle that two or more circular arc cage tools form, the two ends of each circular arc cage tool are provided with the opening of getting laboratory animal for dress.
4. the chronic point source illumination instrument that is subjected to photograph of batch experiment animal as claimed in claim 3, it is characterized in that: the semicircle cage tool by two formed objects forms, each semicircle cage tool comprises upper and lower base plate (1,2) and inside and outside baffle plate (3,4), and the both ends open place of semicircle cage tool is provided with closure plate (5).
5. the chronic point source illumination instrument that is subjected to photograph of batch experiment animal as claimed in claim 4, it is characterized in that: the both sides of the edge of described upper and lower base plate (1,2) are respectively equipped with draw-in groove, insert respectively in the fluting of upper and lower base plate after inside and outside baffle plate (3,4) bending, and be adhesively fixed.
6. the chronic point source illumination instrument that is subjected to photograph of batch experiment animal as claimed in claim 5, it is characterized in that: the two ends of described upper plate (1) slightly are shorter than lower shoe (2), are respectively equipped be used to the draw-in groove that pulls and pushes closure plate (5) in the inboard, two ends of inside and outside baffle plate (3,4).
7. the chronic point source illumination instrument that is subjected to photograph of batch experiment animal as claimed in claim 4 is characterized in that: be equipped with ventilation hole (6) on the upper and lower base plate of semicircle cage tool and inside and outside baffle plate.
8. the chronic point source illumination instrument that is subjected to photograph of batch experiment animal as described in any one in claim 4-7, is characterized in that: described cage tool employing lucite material; Bonding by acetone between inside and outside baffle plate (3,4) and upper and lower base plate (1,2).
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| Application Number | Priority Date | Filing Date | Title |
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| CN201110347503.2A CN103081816B (en) | 2011-11-07 | 2011-11-07 | Chronic point source illumination method and the instrument that is subject to photograph of a kind of batch experiment animal |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201110347503.2A CN103081816B (en) | 2011-11-07 | 2011-11-07 | Chronic point source illumination method and the instrument that is subject to photograph of a kind of batch experiment animal |
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| CN103081816A true CN103081816A (en) | 2013-05-08 |
| CN103081816B CN103081816B (en) | 2016-05-25 |
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Cited By (3)
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| CN111558406A (en) * | 2020-04-28 | 2020-08-21 | 中国人民解放军海军军医大学 | Remote control type large-batch sample point source irradiation rack and irradiation laboratory |
| CN112402814A (en) * | 2020-11-12 | 2021-02-26 | 中国人民解放军海军军医大学 | Fixed shielding device and method for local irradiation of batch animal ionizing radiation with adjustable target area |
| CN112841026A (en) * | 2021-02-07 | 2021-05-28 | 兰州大学 | Plant seed neutron irradiation dose distribution device based on compact D-D neutron generator |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111558406A (en) * | 2020-04-28 | 2020-08-21 | 中国人民解放军海军军医大学 | Remote control type large-batch sample point source irradiation rack and irradiation laboratory |
| CN112402814A (en) * | 2020-11-12 | 2021-02-26 | 中国人民解放军海军军医大学 | Fixed shielding device and method for local irradiation of batch animal ionizing radiation with adjustable target area |
| CN112402814B (en) * | 2020-11-12 | 2022-07-12 | 中国人民解放军海军军医大学 | Fixed shielding device and method for local irradiation of batch animal ionizing radiation with adjustable target area |
| CN112841026A (en) * | 2021-02-07 | 2021-05-28 | 兰州大学 | Plant seed neutron irradiation dose distribution device based on compact D-D neutron generator |
| CN112841026B (en) * | 2021-02-07 | 2022-07-05 | 兰州大学 | Plant seed neutron irradiation dose distribution device based on compact D-D neutron generator |
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| CN103081816B (en) | 2016-05-25 |
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