CN103551216A - Full automatic liquid relief instrument and application thereof - Google Patents
Full automatic liquid relief instrument and application thereof Download PDFInfo
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- CN103551216A CN103551216A CN201310544587.8A CN201310544587A CN103551216A CN 103551216 A CN103551216 A CN 103551216A CN 201310544587 A CN201310544587 A CN 201310544587A CN 103551216 A CN103551216 A CN 103551216A
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- line slideway
- release lever
- carriage release
- mobile foundation
- pipetting
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Abstract
The invention provides a liquid relief workstation. The liquid relief workstation comprises a liquid relief mechanism support and multiple liquid relief mechanisms, wherein the liquid relief mechanism comprises a moving base which is movably assembled on a moving rod of the moving base, a moving rod driving mechanism, a gear which can rotate around a vertical direction, a linear guide rail fixing base and a liquid relief head arranged on the lower end of the moving rod. The invention also provides a liquid relief mechanism. The invention further provides applications of the liquid relief workstation in performing operations of liquid sample adding, liquid diversion and the like. The liquid relief mechanism of the liquid relief workstation provided by the invention can independently carry out vertical or horizontal movement, the lubricating operation is avoided or greatly reduced, and the pollution is avoided.
Description
Technical field
The present invention relates to automatic fluid treatment facility.More specifically, the present invention relates to a kind of liquid instrument and pipetting device wherein of automatically moving, and in the purposes of implementing the aspects such as liquid application of sample, liquid transfer.
Background technology
Develop rapidly along with Life Sci-Tech, what the research work of Biochemical Lab was faced is more complicated research object and the sample size of being on the increase, traditional manual mode of operation can not meet desired high efficiency, accuracy and security in high flux sample treatment process, and in experimental implementation flow process, the automatic operating of part or overall process has become inexorable trend.
Fully automatic liquid processing workstation is by automation mechanized operation and the ingenious biological medicine laboratory automation operating platform merging of liquid handling, and the automatic sample, reagent that can realize sample distributes, ultramicron is moved liquid and the vibration relevant to liquid handling, the operation such as hatch.Can be widely used in the fields such as nucleic acid purification, gene protein order-checking, clone's rapid screening, cell cultivation, biochip sample preparation.
Pipetting device is one of core institution of fully automatic liquid processing workstation, for realizing the actions such as liquid conveying between normal fluid container, extracting, transfer.In the use of modern fully automatic liquid processing workstation, the most frequently used normal fluid container is normal fluid containers such as 8 orifice plates, 96 orifice plates.Wherein, the conventional normal fluid container adjacent holes spacing minimums such as 96 orifice plates in laboratory are 9mm, the about 0.5ml of volume, 8 holes of single-row distribution.Therefore, automated fluid processing workstation, particularly pipetting device wherein, need to be in very little spatial dimension, realize high accuracy and high duplication a plurality of, for example eight move liquid passage at the same time or separately move the work that surges.
The automated fluid processing workstation of prior art and pipetting device exist that mechanism wear is large, noise is large, robust motion is not high, the requirement on machining accuracy of mobile foundation chute is higher, assembling process debugging is numerous and diverse, the defect that workload is large, and daily operation and maintenance loaded down with trivial details, and easily in instrument internal, produce and pollute and the problem of corrosion.
Summary of the invention
The invention provides a kind of novel Automatic Workstation, overcome the problem that in prior art, pipetting device wearing and tearing are large, assembling and setting is numerous and diverse and mechanism's overall operation flatness is poor, and provide maintenance simple, do not produce the internal environment of pollution.
The invention provides a kind of liquor removing workstation, comprising:
(a) pipetting device support;
(b) several pipetting devices, wherein, described pipetting device has:
Mobile foundation;
Be assemblied in movably the carriage release lever of described mobile foundation, described carriage release lever can be done moving relative to described mobile foundation in the vertical direction;
Carriage release lever driving mechanism, comprises and the driving mechanism of the horizontally disposed screw mandrel of described carriage release lever and described screw mandrel, described screw mandrel is by driving connector to be fixedly connected with described carriage release lever;
Be assemblied in gear on mobile foundation and the driving mechanism of described gear, described gear can rotate around vertical direction;
Be fixed on the line slideway holder on mobile foundation; And
What be arranged on carriage release lever lower end moves liquid head;
(c) along continuous straight runs setting, forms the tooth bar of gear pair with the gear of described pipetting device, when gear rotates, drives mobile foundation to move horizontally along tooth bar; And
(d) along continuous straight runs setting, the line slideway parallel with described tooth bar, the slide block of described line slideway is connected and fixes with the line slideway holder of described pipetting device, and mobile foundation can carry out the movement of horizontal direction with the slide block of line slideway along the track of line slideway thus.
In the pipetting device of above-mentioned liquor removing workstation of the present invention, described line slideway holder can be connected and fix with the slide block of line slideway.Described line slideway can along continuous straight runs setting, parallel with aforementioned tooth bar.The slide block of described line slideway is connected and fixes with described line slideway holder, thus line slideway holder and be connected with line slideway holder and fixing mobile foundation can carry out the movement of horizontal direction with the slide block of line slideway along the track of sliding catheter.
Of the present invention aspect one of them, the gear of described liquor removing workstation and tooth bar, and the position set-up mode of line slideway holder and line slideway makes when gear rotates, can realize and drive the mobile foundation fixing with the slide block of line slideway to move horizontally along the slide rail direction of tooth bar and line slideway.For example, gear and line slideway holder are arranged on the same side of frame, corresponding tooth bar and the upper and lower parallel juxtaposition of line slideway.
Of the present invention aspect one of them, described line slideway holder has surface with the slide block of line slideway identical or analogous shape and big or small square surface.For example, the height H 1 of described line slideway holder is greater than 25mm, is preferably greater than 30mm.The line slideway that described line slideway holder can coordinate or use is greater than 25mm for having slide block width w, is preferably greater than the line slideway of 30mm.
Of the present invention, aspect one of them, described in described pipetting device, line slideway holder is connected with mobile foundation by line slideway fixed block.Described line slideway fixed block and above-mentioned mobile foundation can integrally castings or are fixed on mobile foundation by modes such as screw threads.Described line slideway fixed block is used for fixing two described line slideway holders.Conventionally, the height (being often referred to the length of vertical direction) that described line slideway fixed block has the same or analogous width of line slideway holder (being often referred to the length of horizontal direction) and is not less than twice.For example, the height H 2 of described line slideway fixed block is more than or equal to 50mm, preferably greater than or equal to 60mm.
Of the present invention, aspect one of them, the mobile foundation of described pipetting device has tetragonal housing, and its four limits are respectively upper beam, underbeam and two frames.
Of the present invention, aspect one of them, carriage release lever described in the pipetting device of described liquor removing workstation is assemblied in described mobile foundation one side frame movably.
Of the present invention aspect one of them, described in the pipetting device of described liquor removing workstation, for assembling the frame of carriage release lever, there is groove, described slot opening is to the inner side of mobile foundation, described carriage release lever is assemblied in described groove movably, a part for carriage release lever is outside groove, give prominence to left frame inner surface, the ledge of this carriage release lever can be used for being fixed and being connected with the driving connector of carriage release lever driving mechanism.
Of the present invention aspect one of them, carriage release lever described in the pipetting device of described liquor removing workstation is assemblied in the frame on described mobile foundation movably by being arranged on the carriage release lever sliding sleeve of frame, wherein said carriage release lever sliding sleeve is fixedly connected with frame, and described carriage release lever can move in carriage release lever sliding sleeve.
Of the present invention, aspect one of them, carriage release lever sliding sleeve described in the pipetting device of described liquor removing workstation is sliding sleeve prepared by macromolecule polymer material.The easy iglidur of Gus (Igus) company for example
series, as iglidur
g, iglidur
w300, iglidur
j, iglidur
x and iglidur
m250 etc.Part prepared by these polymeric materials has the characteristic of exempting to lubricate (self-lubricating), and has good soda acid resistance, and shock-absorbing performance is good, without sealing or oil-scraping ring, and convenient installation and replacement.Preferably, carriage release lever sliding sleeve described in pipetting device of the present invention is not metallic material parts.
Of the present invention, aspect one of them, carriage release lever described in the pipetting device of described liquor removing workstation is hollow grooved tube.In hollow grooved tube, can be used for installing wire or move fluid catheter.
Of the present invention aspect one of them, the drive motors that described in the pipetting device of described liquor removing workstation, the driving mechanism of screw mandrel is described screw mandrel.Described screw mandrel drives by drive motors.Preferably, described drive motors is servomotor.
Of the present invention aspect one of them, described screw mandrel by feed screw nut with drive connector to be fixedly connected with carriage release lever.For example, feed screw nut's spinning, on screw mandrel, drives one end of connector to be fixedly connected with carriage release lever, and the other end is fixed on described feed screw nut outside.Preferably, wherein said feed screw nut is high molecular polymer preparation.Choosing, feed screw nut described in pipetting device of the present invention is not metallic material parts.
Of the present invention, aspect one of them, move liquid head and have limited block described in the pipetting device of described liquor removing workstation, and pipet stand, be connected to the conduit of pipet stand below, described conduit can connect removable liquid transfer gun head.Of the present invention, wherein aspect another, described in described pipetting device, on conduit, be provided with de-pipe box cylinder.Of the present invention wherein aspect another, described in move liquid head and there is level sensor.
Of the present invention, aspect one of them, described liquor removing workstation also comprises along continuous straight runs setting, forms the tooth bar of gear pair with described gear, when gear rotates, drives mobile foundation to move horizontally along tooth bar.
Of the present invention aspect one of them, described liquor removing workstation also comprises along continuous straight runs setting, the line slideway parallel with described tooth bar, the slide block of described line slideway is connected and fixes with described line slideway holder, and mobile foundation can carry out the movement of horizontal direction with the slide block of line slideway along the track of line slideway thus.Of the present invention, aspect one of them, described mobile foundation is be connected and fix with the slide block of line slideway by line slideway holder (also can comprise line slideway fixed bit).
Of the present invention, aspect one of them, the position set-up mode of wherein said gear and line slideway holder makes when gear rotates, and drives mobile foundation to move horizontally along the slide rail direction of tooth bar and line slideway.Mobile foundation is be connected and fix with the slide block of line slideway by line slideway holder (also can comprise line slideway fixed bit).For example, gear and line slideway holder are arranged on the same side of one of them frame, corresponding tooth bar and the upper and lower parallel juxtaposition of line slideway.
Of the present invention, aspect one of them, move liquid head and have limited block described in described pipetting device, and pipet stand, be connected to the conduit of pipet stand below, described conduit can connect replaceable liquid transfer gun head.Of the present invention, wherein aspect another, on described conduit, be provided with de-pipe box cylinder.Of the present invention, wherein aspect another, the wherein said liquid head that moves has level sensor.Described level sensor can be arranged on pipet stand below.
Of the present invention aspect one of them, described liquor removing workstation has several (for example four or eight) aforementioned pipetting device, two or more in wherein said several pipetting device assemble side by side, the carriage release lever of two or more pipetting devices of described assembling arranged side by side is arranged point-blank, and the gear of two or more pipetting devices of described assembling arranged side by side and same tooth bar formation gear pair.Of the present invention, wherein aspect another, in two or more pipetting devices of described assembling arranged side by side, the line slideway holder of the mobile foundation of two pipetting devices is connected with two slide blocks of same line slideway.For example, by the line slideway holder on adjacent two mobile foundations, be separately fixed at the first half or the latter half on the line slideway fixed block of mobile foundation, two mobile foundations in several pipetting devices of described assembling arranged side by side can be connected with two slide blocks of same line slideway respectively thus.Described gear and tooth bar, and the position set-up mode of line slideway holder and line slideway makes when gear rotates, and can realize and drive the mobile foundation fixing with the slide block of line slideway to move horizontally along the slide rail direction of tooth bar and line slideway.
Of the present invention, aspect one of them, described liquor removing workstation comprises four or eight described pipetting devices.In comprising the liquor removing workstation of eight described pipetting devices, described eight pipetting devices divide two groups that are in a parallel set, and every group of four pipetting devices assemble side by side, and the gear of every group of four pipetting devices and same tooth bar form gear pair.Of the present invention, wherein aspect another, in described every group of four pipetting devices, the line slideway holder of mobile foundation of two pipetting devices and two slide blocks of same line slideway are connected.For example, by the line slideway holder on adjacent two mobile foundations, be separately fixed at the first half or the latter half on the line slideway fixed block of mobile foundation, two mobile foundations in four of described assembling arranged side by side pipetting devices can be connected with two slide blocks of same line slideway respectively thus.Described gear and tooth bar, and the position set-up mode of line slideway holder and line slideway makes when gear rotates, and can realize and drive the mobile foundation fixing with the slide block of line slideway to move horizontally along the slide rail direction of tooth bar and line slideway.In liquor removing workstation of the present invention, the carriage release lever of described every group of four pipetting devices is arranged point-blank, is crisscross arranged with the carriage release lever of four pipetting devices of another group, and the liquid transfer gun head of eight described pipetting devices can be arranged point-blank.
Of the present invention aspect one of them, described liquor removing workstation also comprises other checkout gear or container, for example syringe pump, heating plate, oscillator, ELIASA ,PCRYi, handgrip mechanism, and the various containers that hold sample or reagent, as microcentrifugal tube, centrifuge tube, PCR microwell plate, deep-well plates, micro-porous filtration plate, pipe support etc.
Of the present invention, aspect one of them, also provide a kind of aforesaid pipetting device.Of the present invention, aspect one of them, also provide a kind of multi-channeled transposition arrangement that adopts described pipetting device, described multi-channeled transposition arrangement is equipped with two, four or eight described pipetting devices.
Pipetting device of the present invention, device and instrument can be realized each pipetting device in running and carry out independently horizontal or vertical movement, and integrally-built layout is more reasonable, space is clearer and more definite, and difficulty and the complexity of its assembling and setting are also reduced greatly.In addition, pipetting device of the present invention adopts self-lubricating, non-maintaining macromolecule polymer material for the preparation of the sliding sleeve of fixing and make its carriage release lever sliding therein, the slip of hollow square tube in high molecular polymer sliding sleeve is smooth-going, soft, noise is little, and avoid or reduced the operation that it is lubricated, the pollution of having avoided grease class lubricator likely to cause pipetting.In addition, pipetting device of the present invention use for realizing the lead screw pair of moving the motion of liquid head erect direction, with driven by servomotor leading screw, can overcome in prior art mechanical oscillation large, unsettled defect.And wherein feed screw nut is taked gap-eliminating structure, can eliminate most of mechanical clearance of moving between feed screw nut and leading screw, can further realize more accurate transmission, thereby realize, move liquid meticulous pipetting on first watch.Wherein, feed screw nut also can be polymeric material preparation, thus, drives and moves the mechanism that liquid head vertical direction moves and can avoid or reduce the operation that it is lubricated, the pollution of having avoided grease class lubricator likely to cause pipetting.
Accompanying drawing explanation
Fig. 1 is local interior's installation drawing of the liquor removing workstation of the preferred embodiment of the present invention;
Fig. 2 is the stereogram of pipetting device of the liquor removing workstation of the preferred embodiment of the present invention;
Fig. 3 is the cutaway view of pipetting device of the liquor removing workstation of the preferred embodiment of the present invention;
Fig. 4 is the partial assembled schematic diagram of pipetting device of the liquor removing workstation of the preferred embodiment of the present invention;
Fig. 5 is the schematic perspective view of another angle of part-structure of the liquor removing workstation of the preferred embodiment of the present invention.
In accompanying drawing, each mark is respectively:
1 mobile foundation
2 square tube sliding sleeves
201 square tube sliding sleeve projections
3 screw mandrel shaft couplings
4 screw mandrels
6 feed screw nuts
7 hollow square bars
8 gear couplings
9 frame backboards
11 motor cabinets
12 gear drive motors
13 carriage release lever drive motors
14 gear-bearings
15 gear shafts
16 gears
17 drive connector
18 top boards
19 base plates
21 upper beams
22 underbeams
23 left frames
231 left frame grooves
24 left frames
25 pipet stands
26 conduits
27 pipet stands
28 de-pipe box cylinders
30 liquid transfer gun heads
31 limited blocks
33 cablings are walked pipe joint
34 line slideway holders
35 line slideway fixed blocks
36 circuit board box
40 line slideways
41 line slideway slide rails
42 straight-line guide rail slide blocks
43 tooth bars
The specific embodiment
For a better understanding and interpretation of the present invention, the present invention is described in further detail below with reference to accompanying drawings.
Fig. 1 is local interior's installation drawing of liquor removing workstation according to a preferred embodiment of the present invention.
Liquor removing workstation of the present invention generally has eight for implementing the pipetting device 38 of liquid application of sample, liquid transfer.Described eight pipetting devices divide two groups that are in a parallel set, and every group of four pipetting devices assemble side by side.Fig. 1 illustrates the interior section device schematic diagram of liquor removing workstation of the present invention, and it comprises the device of above-mentioned one group of four pipetting device that assemble side by side.Described pipetting device has mobile foundation 1, and described mobile foundation has tetragonal housing.What described pipetting device also had carriage release lever on a side frame that is vertically assemblied in movably mobile foundation 7 and was arranged on this carriage release lever lower end moves liquid head 30.Described carriage release lever can be done moving up and down of relatively described mobile foundation in vertical direction in described frame.The driving mechanism moving up and down that drives described carriage release lever to do relatively described mobile foundation comprises and being assemblied on described mobile foundation, with the screw mandrel 4 of described carriage release lever level.Moving liquid head is the mechanism for functions such as liquid induction, conveying, absorptions, can, with the moving up and down of described carriage release lever, realize and process the function that is arranged on the fluid sample in the vessel ware that moves liquid head below.
Described pipetting device also has the gear 16 that can rotate around vertical direction that is assemblied in mobile foundation frame outside, and described gear can be secondary with horizontally disposed tooth bar 43 formative gears, when gear rotates, drives mobile foundation to move horizontally along tooth bar.Described pipetting device also has on the mobile foundation of being fixed on, and for the slide block 42 with line slideway, is connected and fixing line slideway holder, and mobile foundation can slide to realize along horizontally disposed line slideway 40 and move horizontally thus.Gear 16 and tooth bar 43, and the position set-up mode of line slideway holder 34 and line slideway 40 makes, when gear 16 rotation, can realize and drive the mobile foundation fixing with the slide block of line slideway to move horizontally along the slide rail direction of tooth bar and line slideway.
The carriage release lever of every group of four pipetting devices of liquor removing workstation of the present invention is arranged point-blank, is crisscross arranged with the carriage release lever of four pipetting devices of another group, and the liquid transfer gun head of eight described pipetting devices can be arranged point-blank.
In preferred embodiment as described in Figure, the gear of every group of four pipetting devices of liquor removing workstation of the present invention and same tooth bar form gear pair, wherein the line slideway holder 34 on adjacent two mobile foundations is connected with two slide blocks of same line slideway respectively, and every group of four pipetting devices are connected with two line slideways thus.A described tooth bar and described two line slideways be arranged in parallel up and down.
Liquor removing workstation of the present invention also can have casing (not shown) and support the support of aforementioned pipetting device.Support can comprise pillar, crossbeam and the backboard etc. for supporting and/or set up pipetting device.As shown in Figure 1, a described tooth bar 43 and described two line slideways 40 be arranged in parallel up and down, are fixed on backboard 9.Backboard 9 can be fixed on chassis sidewall or be fixed on the crossbeam that is erected at internal body.
Fig. 2 is the schematic perspective view of pipetting device according to a preferred embodiment of the present invention.Fig. 3 is the internal view of the pipetting device of a preferred embodiment of the present invention.
As shown in Figures 2 and 3, this pipetting device has mobile foundation, and described mobile foundation has tetragonal housing; What described pipetting device also had the carriage release lever of (left frame 23 as shown) on a side frame that is vertically assemblied in movably mobile foundation and was arranged on this carriage release lever lower end moves liquid head, described carriage release lever can be done moving up and down of relatively described mobile foundation in vertical direction in described frame, moving liquid head is the mechanism for functions such as liquid induction, conveying, absorptions, can, with the moving up and down of described carriage release lever, realize and process the function that is arranged on the fluid sample in the vessel ware that moves liquid head below; Described pipetting device also has for driving described carriage release lever to do the driving mechanism moving up and down of relatively described mobile foundation, comprise and being assemblied on described mobile foundation, with the screw mandrel of described carriage release lever level and the drive motors of described screw mandrel, described screw mandrel is by driving connector to be fixedly connected with described carriage release lever; Described pipetting device also has and is assemblied in the gear that can rotate around vertical direction in mobile foundation frame outside and the driving mechanism of described gear, described gear can form gear pair with horizontally disposed tooth bar, when gear rotates, drive mobile foundation to move horizontally along tooth bar; Described pipetting device also has on the mobile foundation of being fixed on, and for being connected with the slide block of line slideway and fixing line slideway holder, mobile foundation can slide to realize along horizontally disposed line slideway and move horizontally thus.
In the pipetting device of the preferred embodiment of the present invention shown in Fig. 2, described mobile foundation is cuboid parts, has tetragonal housing, and its four limits are respectively upper beam 21, underbeam 22, left frame 23 and left frame 24.Described pedestal is conventionally by can alleviator weight and reduce metal material that liquid adheres to and make as materials such as aluminium or stainless steels.Described frame has certain thickness, with to motor, for holding the devices such as the circuit board box effect of providing support of the circuit board of controlling the equipment such as motor, and can be for holding and supporting aforementioned carriage release lever.For example, described frame can have the thickness similar to motor width (such as the diameter of column type motor or the width of rectangular build motor etc.), or has the thickness of the width (such as the diameter of cylindrical carriage release lever or the width of square carriage release lever etc.) that is greater than described carriage release lever.Of the present invention, aspect one of them, described frame has the thickness that is greater than 0.5cm.Employing has the design of frame, can reduce the advantages such as component weight.In other embodiments, mobile foundation also can be for not having the cuboid parts of hollow space.Now, the part on its four limits is also equal to aforementioned tetragonal housing, i.e. " upper beam, underbeam, left frame and left frame ".
In the diagram preferred embodiment of the present invention, left frame 23 is for arranging the aforementioned carriage release lever moving up and down 7 of doing relatively described mobile foundation in described frame.In diagram preferred embodiment, left frame 23 is hollow structure, and described carriage release lever 7 is assemblied in described left frame movably.In diagram preferred embodiment, left frame 23 has groove, described slot opening is to the inner side (facing a side of left frame) of mobile foundation, described carriage release lever is assemblied in described groove movably, a part for carriage release lever is outside groove, give prominence to left frame inner surface, the ledge of this carriage release lever can be used for being fixed and being connected with the driving mechanism that drives carriage release lever to move up and down.
As shown in Figures 2 and 3, the driving mechanism moving up and down of doing relatively described mobile foundation for driving in described carriage release lever on the left side frame comprises and is assemblied in described mobile foundation, with the screw mandrel 4 of described carriage release lever level and the drive motors 13 of described screw mandrel.Preferably, described drive motors 13 is servomotor.Described drive motors 13 is connected and transmission with screw mandrel 4 by shaft coupling 3.The two ends up and down of described screw mandrel are limited between the upper beam and underbeam of mobile foundation by bearing.Drive motors 13 can be arranged on the top of described screw mandrel.In diagram the preferred embodiments of the present invention, the upper beam of described mobile foundation has groove, can hold shaft coupling 3 therein, and top board 18 is set in addition above upper beam, and described drive motors 13 vertical racks are located at described top board 18 tops.Described top board can have and the same or analogous length of upper beam and width.Described top board also can have the length large compared with upper beam, except can be used for setting up described drive motors 13, also can be used for setting up the devices such as circuit board box (as the circuit board box 29 in Fig. 1) that hold the circuit board of controlling the equipment such as motor.This design can be saved the inner space of the automatic moving liquid instrument that adopts pipetting device of the present invention greatly, is convenient to electric wire, moves setting up of fluid catheter.
Described screw mandrel 4 is fixedly connected with carriage release lever 7 with driving connector 17 by feed screw nut 6.Wherein, feed screw nut's 6 spinnings, on screw mandrel, drive one end of connector 17 to be fixedly connected with carriage release lever 7 by modes such as screws, and the other end can be fixed on feed screw nut 6 outsides by spinning mode.When screw mandrel rotates under drive motors 13 drives, drive connector 17 within the scope of the depth of beam up and down of mobile foundation, to move up and down, thereby drive carriage release lever to move up and down.Of the present invention, aspect one of them, described feed screw nut can be taked gap-eliminating structure, eliminates most of mechanical clearance of moving between feed screw nut and leading screw.Of the present invention, aspect one of them, described feed screw nut adopts macromolecule polymer material preparation.The easy iglidur of Gus (Igus) company for example
series, as iglidur
g, iglidur
w300, iglidur
j, iglidur
x and iglidur
m250 etc.Part prepared by these polymeric materials has the characteristic of exempting to lubricate (self-lubricating), and has good soda acid resistance, and shock-absorbing performance is good, without sealing or oil-scraping ring, and convenient installation and replacement.
Carriage release lever shown in pipetting device of the present invention movably vertically (i.e. the direction parallel with frame) is fixed on mobile foundation.Preferably, carriage release lever shown in is fixed in one of them frame of mobile foundation movably.For example, by being arranged on the carriage release lever sliding sleeve at the upper and lower two ends of frame, be assemblied in movably in the frame on described mobile foundation, wherein said carriage release lever sliding sleeve is fixedly connected with frame, and described carriage release lever can move in carriage release lever sliding sleeve.In the illustrated embodiment, described carriage release lever is square pole 7, fixing movably at the two ends up and down of mobile foundation by square tube sliding sleeve 2 and left frame 23.Fig. 4 is described square pole 7, the annexation schematic diagram of square tube sliding sleeve 2 and left frame 23.As shown in Figure 4, square tube sliding sleeve is fixed on wherein (illustrated upper end for example, one end of left frame 23, it also has same structure in lower end) inside (for example coordinating with the groove 231 at left frame edge by the projection 201 on square tube sliding sleeve), square pole 7 is assemblied in square tube sliding sleeve 2 slidably.Of the present invention, aspect one of them, described square tube sliding sleeve adopts the polymeric material preparation of self-lubricating.The easy iglidur of Gus (Igus) company for example
series, as iglidur
g, iglidur
w300, iglidur
j, iglidur
x and iglidur
m250 etc.These polymeric materials have good soda acid resistance, and shock-absorbing performance is good, without sealing or oil-scraping ring, and convenient installation and replacement.
In the illustrated embodiment, carriage release lever shown in is the square pole 7 of hollow.Described carriage release lever adopts hollow grooved tube, can be used for installing wire or moves fluid catheter etc.For example, can be used for cabling, comprise with conduit and being connected, for the catheter of conveying and the extracting of liquid, and the electric wire that uses of all parts and mechanism, the cable of level sensor for example, the electric wire of motor etc.On the top of square pole 7, cabling can be set and walk pipe joint 33.
Pipetting device of the present invention also has the gear 16(that can rotate around vertical direction that is arranged on (for example scuncheon or outside) on mobile foundation and on horizontal plane, rotates).In the illustrated embodiment, described gear setting is to assemble the outside of opposite side frame of the frame of described carriage release lever 7.Described gear can form gear pair with horizontally disposed tooth bar, while realizing thus gear rotation, drives mobile foundation to move horizontally along tooth bar.The rotation of gear is driven by gear drive motor 12.Gear drive motor 12 can be arranged on gear top, for example, be vertically set on the motor cabinet 11 in the frame outside that is fixed on mobile foundation.Gear drive motor 12 passes through shaft coupling 8 to gear 16 transmissions.Preferably, described gear drive motor is servomotor.
Pipetting device of the present invention also has on the mobile foundation of being fixed on, the line slideway holder 34 being fixed for the slide block with line slideway.Of the present invention, aspect one of them, described line slideway holder 34 is fixed on mobile foundation frame (for example illustrated left frame 24) outside.Line slideway holder has the square surface with the same or similar size in surface of the slide block of line slideway.Of the present invention, aspect one of them, the height H 1 of described line slideway holder is not less than 25mm, is preferably not less than 30mm.Pipetting device of the present invention or to adopt line slideway that the automatic moving liquid instrument of described pipetting device can coordinate or use be that to have slide block width w(be the slide block of the line slideway length in the vertical direction of the slide rail with line slideway) be not less than 25mm, be preferably not less than the line slideway of 30mm.Employing has the line slideway of above-mentioned slide block width and/or the line slideway holder of above-mentioned height, has greatly improved unexpectedly the stability of pipetting device operation of the present invention.The described line slideway holder of pipetting device of the present invention and the slide block of line slideway can be fixed by modes such as screws, and mobile foundation can slide along line slideway mobile thus.At pipetting device of the present invention or adopt the moving in liquid instrument of pipetting device of the present invention, line slideway is horizontally disposed with, and realizes thus mobile foundation and moves horizontally along line slideway direction.
Of the present invention, aspect one of them, pipetting device of the present invention has line slideway fixed block 35, and described line slideway holder 34 can be by being fixed on described line slideway fixed block 35 and is connected with mobile foundation.Described line slideway fixed block 35 and mobile foundation can integrally castings, or are fixed on mobile foundation by modes such as screws.In a kind of embodiment, line slideway fixed block 35 can be a part for frame therein.Of the present invention, aspect one of them, the height of described line slideway fixed block is more than or equal to the height H 2 of the line slideway holder of twice.Preferably, the height of described line slideway fixed block is not less than 50mm, is preferably not less than 60mm.Line slideway holder 34 can be fixed on the first half or the latter half of line slideway fixed block 35.
In the pipetting device of the preferred embodiment of the present invention, for example, in preferred embodiment shown in the drawings, the same outside of frame that the gear 16 that can rotate around vertical axis and line slideway holder 34 be arranged on mobile foundation, left frame outside as shown.As shown in Fig. 1 or Fig. 5, can be arranged in parallel with the line slideway 40 being connected with line slideway holder 34 with the tooth bar 43 of gear 16 formative gear pairs.The position set-up mode of gear 16 and line slideway holder 34 makes when gear 16 rotates, and can realize and drive the mobile foundation fixing with the slide block of line slideway to move horizontally along the slide rail direction of tooth bar and line slideway.Preferably, gear 16 and line slideway holder 34 are arranged on the same side of frame, corresponding tooth bar 43 and the upper and lower parallel juxtaposition of line slideway 40.Thus, can greatly save the inner space of the automatic moving liquid instrument that adopts pipetting device of the present invention.In other embodiments, gear 16 and line slideway holder 34 also can be arranged on other suitable position of mobile foundation, can realize and drive the mobile foundation fixing with the slide block of line slideway to move horizontally along the slide rail direction of tooth bar and line slideway.
The pipetting device of the described preferred embodiment of the present invention also have be fixedly mounted on carriage release lever 7 lower ends move liquid head.Moving liquid head is for the mechanism of the functions such as liquid induction, extracting, has comprised the parts of realizing these functions.In the illustrated embodiment, this moves liquid head and comprises pipet stand 27, de-pipe box cylinder 28, conduit 26, limited block 31, liquid transfer gun head 30 and liquid level detector 25.Wherein, pipet stand 27 is for setting up liquid level detector 25 and conduit 26, and conduit 26 is for connecting liquid transfer gun head, limited block 31.Thereby de-pipe box cylinder 28 is for realizing the separated object that reaches automatic replacing of liquid transfer gun head and conduit.Because the combination of liquid transfer gun head and conduit is very tight, de-pipe box cylinder need to be realized the separated of liquid transfer gun head and conduit in very little distance range.The design that pipetting device of the present invention moves liquid head makes de-pipe box cylinder can reach this object.Liquid level detector can be used for sensing and moves the middle liquid of normal fluid container (for example 8 orifice plates, 96 orifice plates) of liquid head below and the distance between liquid transfer gun head, signal feedback is arrived to automatic operation station, and under programme-control, signal feedback, give the instrument of controlling pipetting device as required.
Full-automatic liquor removing workstation of the present invention can assemble four or eight described pipetting devices.Described four or eight described pipetting devices can independent horizontals or the movement of vertical direction, also the synchronously movement of occurred level or vertical direction, and identical horizontal range occurs two adjacent pipetting devices changes, make adjacent liquid transfer gun head that identical horizontal range occur and change.
Fig. 5 is the schematic perspective view of another angle of part-structure of the full-automatic liquor removing workstation of the preferred embodiment of the present invention.
Full-automatic liquor removing workstation of the present invention is assembling four or eight described pipetting devices conventionally, described eight pipetting devices are divided into parallel two groups, every group of four pipetting devices assemble side by side, the carriage release lever of every group of four pipetting devices is arranged point-blank, line slideway holder 34 on the mobile foundation of adjacent two pipetting devices is separately fixed at the first half or the latter half on line slideway fixed block 35, the mobile foundation of two in same group of four pipetting devices can be connected (by line slideway holder and line slideway fixed bit) with two slide blocks of same line slideway respectively thus, thereby greatly save the inner space of the automatic moving liquid instrument that adopts pipetting device of the present invention.In full-automatic liquor removing workstation of the present invention, the carriage release lever of every group of four pipetting devices is arranged point-blank, is crisscross arranged with the carriage release lever of four pipetting devices of another group, and the liquid transfer gun head of eight described pipetting devices can be arranged point-blank.
The multi-channeled transposition arrangement of eight pipetting device formation can be processed the normal fluid containers such as 8 orifice plates, 24 orifice plates, 96 orifice plates easily.Wherein each pipetting device can move up and down independently.
The invention described above liquor removing workstation can be used for to liquid respond to, the operation such as detection, absorption and discharge, thereby realize the transfer of liquid.
The present invention also provides pipetting device, multi-channeled transposition arrangement or the full-automatic liquor removing workstation of the invention described above for liquid is responded to, surveys, drawn and discharges, thereby realizes the purposes of the transfer of liquid.
In operation, the whole workflow of the liquor removing workstation of the invention described above preferred embodiment is as follows:
Need to for example, when moving normal fluid container (8 orifice plates, 96 orifice plates) below liquid head and carry out the absorption of liquid or emit action, under programme-control, make pipetting device move to above normal fluid container.Liquid level detector sensing moves the normal fluid liquid in containers of liquid head below and the distance between liquid transfer gun head, signal feedback is arrived to control system, can make screw mandrel rotate by carriage release lever drive motors 13, screw mandrel makes carriage release lever 7 do vertically and move in the vertical hole of mobile foundation left frame by driving connector 17, thereby realizes moving up and down of imbibition head.When moving liquid pedestal and need to carry out mobile in horizontal direction, the rotation of gear drive motor 12 driven wheel 16 occurred level directions, drives mobile foundation by fixing with the slide block of line slideway thus, can move horizontally along line slideway.
The design of pipetting device of the present invention makes each pipetting device in the liquor removing workstation that adopts it can carry out completely independently horizontal or vertical movement, mutually, there is no annexation. such structure is arranged so that integrally-built layout is more reasonable, space is clearer and more definite, and difficulty and the complexity of its assembling and setting are also reduced greatly.When carrying out the safeguarding of pipetting device, only need to certain damage wherein move liquid passage maintain and replace, without the dismounting that relates to other passages.
In addition, in liquor removing workstation of the present invention, control the parts move in the mechanism that liquid head moves and adopt self-lubricating, non-maintaining high molecular polymer preparation more, avoid or greatly reduced the operation that it is lubricated, the pollution of having avoided grease class lubricator likely to cause pipetting.
Although describe in detail about example embodiment of the present invention and advantage thereof, be to be understood that in the situation that do not depart from the protection domain that spirit of the present invention and claims limit, can carry out various variations, substitutions and modifications to these embodiment.For other examples, when those of ordinary skill in the art should easily understand within keeping protection domain of the present invention, the order of processing step can change.
In addition, range of application of the present invention is not limited to technique, mechanism, manufacture, material composition, means, method and the step of the specific embodiment of describing in description.From disclosure of the present invention, as those of ordinary skill in the art, will easily understand, for the technique, mechanism, manufacture, material composition, means, method or the step that have existed or be about to develop at present later, wherein they carry out identical function or the identical result of acquisition cardinal principle of corresponding embodiment cardinal principle of describing with the present invention, according to the present invention, can apply them.Therefore, claims of the present invention are intended to these technique, mechanism, manufacture, material composition, means, method or step to be included in its protection domain.
Claims (12)
1. a liquor removing workstation, comprising:
(a) pipetting device support;
(b) several pipetting devices, wherein, described pipetting device has:
Mobile foundation (1);
The carriage release lever (7) that is assemblied in movably described mobile foundation (1), described carriage release lever can be done moving relative to described mobile foundation in the vertical direction; Preferably, wherein said carriage release lever is hollow grooved tube;
Carriage release lever driving mechanism, comprises and the driving mechanism of the horizontally disposed screw mandrel of described carriage release lever (7) (4) and described screw mandrel, described screw mandrel (4) is by driving connector (17) to be fixedly connected with described carriage release lever (7);
Be assemblied in gear (16) on mobile foundation (1) and the driving mechanism of described gear, described gear (16) can rotate around vertical direction;
Be fixed on the line slideway holder (34) on mobile foundation (1); And
What be arranged on carriage release lever (7) lower end moves liquid head;
(c) along continuous straight runs setting, with the tooth bar (43) of gear (16) the formative gear pair of described pipetting device, when gear rotates, drives mobile foundation to move horizontally along tooth bar; And
(d) along continuous straight runs setting, the line slideway parallel with described tooth bar, the slide block of described line slideway is connected and fixes with the line slideway holder (34) of described pipetting device, and mobile foundation can carry out the movement of horizontal direction with the slide block of line slideway along the track of line slideway thus.
2. liquor removing workstation claimed in claim 1, wherein said mobile foundation has tetragonal housing, and described carriage release lever (7) is assemblied in described mobile foundation (1) one side frame movably.
3. liquor removing workstation claimed in claim 2, wherein said have groove for assembling the frame of carriage release lever (7), described slot opening is to the inner side of mobile foundation, described carriage release lever is assemblied in described groove movably, a part for carriage release lever is outside groove, give prominence to left frame inner surface, the ledge of this carriage release lever can be used for being fixed and being connected with the driving connector (17) of carriage release lever driving mechanism.
4. liquor removing workstation claimed in claim 3, wherein said carriage release lever is assemblied in the frame on described mobile foundation movably by being arranged on the carriage release lever sliding sleeve of frame, wherein said carriage release lever sliding sleeve is fixedly connected with frame, described carriage release lever can move in carriage release lever sliding sleeve, preferably, described carriage release lever sliding sleeve is high molecular polymer sliding sleeve.
5. liquor removing workstation claimed in claim 1, the driving mechanism of wherein said screw mandrel comprises the drive motors of described screw mandrel, preferred, described gear drive motor is servomotor.
6. liquor removing workstation claimed in claim 1, wherein said screw mandrel (4) is fixedly connected with carriage release lever (7) with driving connector (17) by feed screw nut (6), wherein, feed screw nut (6) spinning is on screw mandrel, drive one end of connector (17) to be fixedly connected with carriage release lever 7, the other end is fixed on described feed screw nut (6) outside, and preferred, wherein said feed screw nut is high molecular polymer feed screw nut.
7. liquor removing workstation claimed in claim 1, wherein said line slideway holder (34) is connected with mobile foundation by line slideway fixed block (35),
Preferably, the height H 1 of wherein said line slideway holder (34) is greater than 25mm, is preferably greater than 30mm; And/or
Preferably, the height H 2 of wherein said line slideway fixed block is more than or equal to 50mm, preferably greater than or equal to 60mm.
8. the liquor removing workstation described in any one in claim 1-7, two or more in wherein said several pipetting device assemble side by side, the carriage release lever of two or more pipetting devices of described assembling arranged side by side is arranged point-blank, and the gear of two or more pipetting devices of described assembling arranged side by side and same tooth bar formation gear pair.
9. liquor removing workstation claimed in claim 8, in two or more pipetting devices of wherein said assembling arranged side by side, the line slideway holder 34 of the mobile foundation of two pipetting devices is connected with two slide blocks of same line slideway, for example, in two or more pipetting devices of described assembling arranged side by side, the line slideway holder 34 of the mobile foundation of adjacent two pipetting devices is separately fixed at the first half or the latter half on its line slideway fixed block.
10. the liquor removing workstation described in any one in claim 1-9, it comprises four or eight described pipetting devices.
11. liquor removing workstations claimed in claim 10, it comprises eight described pipetting devices, described eight pipetting devices divide two groups that are in a parallel set, every group of four pipetting devices assemble side by side, the gear of every group of four pipetting devices and same tooth bar form gear pair, and in described every group of four pipetting devices, the line slideway holder of mobile foundation and two slide blocks of same line slideway of two pipetting devices are connected, for example, wherein the line slideway holder 34 on adjacent two mobile foundations is separately fixed at the first half or the latter half on line slideway fixed block 35.
Liquor removing workstation described in 12. claims 10 or 11, wherein the carriage release lever of every group of four pipetting devices is arranged point-blank, be crisscross arranged with the carriage release lever of four pipetting devices of another group, the liquid transfer gun head of eight described pipetting devices can be arranged point-blank.
Priority Applications (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310544587.8A CN103551216A (en) | 2013-11-06 | 2013-11-06 | Full automatic liquid relief instrument and application thereof |
| CN201410104387.5A CN103846113B (en) | 2013-11-06 | 2014-03-20 | Full-automatic shifting liquid instrument and its purposes |
| US15/034,373 US20160266162A1 (en) | 2013-11-06 | 2014-05-11 | Fully-automatic pipetting instrument and use thereof |
| PCT/CN2014/090402 WO2015067180A1 (en) | 2013-11-06 | 2014-11-05 | Fully-automatic pipetting instrument and use thereof |
| HK14112362.9A HK1198962A1 (en) | 2013-11-06 | 2014-12-09 | Full-automatic pipetting instrument and application thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310544587.8A CN103551216A (en) | 2013-11-06 | 2013-11-06 | Full automatic liquid relief instrument and application thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN103551216A true CN103551216A (en) | 2014-02-05 |
Family
ID=50005669
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201310544587.8A Pending CN103551216A (en) | 2013-11-06 | 2013-11-06 | Full automatic liquid relief instrument and application thereof |
| CN201410104387.5A Expired - Fee Related CN103846113B (en) | 2013-11-06 | 2014-03-20 | Full-automatic shifting liquid instrument and its purposes |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410104387.5A Expired - Fee Related CN103846113B (en) | 2013-11-06 | 2014-03-20 | Full-automatic shifting liquid instrument and its purposes |
Country Status (2)
| Country | Link |
|---|---|
| CN (2) | CN103551216A (en) |
| HK (1) | HK1198962A1 (en) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2015067180A1 (en) * | 2013-11-06 | 2015-05-14 | 北京自由度科学机器有限公司 | Fully-automatic pipetting instrument and use thereof |
| WO2015139667A1 (en) * | 2014-03-21 | 2015-09-24 | 北京自由度科学机器有限公司 | Full-automatic pipetting station and application thereof |
| CN109142708A (en) * | 2018-09-02 | 2019-01-04 | 广州源起健康科技有限公司 | A kind of Full-automatic magnetic beads time-resolved fluorescence immunoassay instrument |
| CN110361230A (en) * | 2018-04-09 | 2019-10-22 | 冷泉港生物科技股份有限公司 | Detect the automatic fluid injection method and device of monogenic inheritance disease |
| WO2022021377A1 (en) * | 2020-07-31 | 2022-02-03 | 杭州九洋生物科技有限公司 | Pipette and pipetting method |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102014108688A1 (en) * | 2014-06-20 | 2015-12-24 | Hamilton Bonaduz Ag | Pipetting device with modular pipetting head |
| CN106350438B (en) * | 2016-10-27 | 2018-05-22 | 上海理工大学 | Improve the device that monoclonal selects instrument flux |
| CN110849701B (en) * | 2019-11-04 | 2023-02-28 | 山东见微生物科技有限公司 | Sample processing apparatus |
| CN112300911A (en) * | 2020-10-27 | 2021-02-02 | 广州和实生物技术有限公司 | Nucleic acid detector and nucleic acid detection method |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5055263A (en) * | 1988-01-14 | 1991-10-08 | Cyberlab, Inc. | Automated pipetting system |
| CN101596469B (en) * | 2009-07-03 | 2011-12-28 | 烟台艾德康生物科技有限公司 | Multi-channel loading device |
| CN203170349U (en) * | 2013-01-15 | 2013-09-04 | 北京金麦格生物技术有限公司 | Liquid transferring mechanism |
| CN203173796U (en) * | 2013-01-15 | 2013-09-04 | 北京金麦格生物技术有限公司 | Liquid transferring device |
-
2013
- 2013-11-06 CN CN201310544587.8A patent/CN103551216A/en active Pending
-
2014
- 2014-03-20 CN CN201410104387.5A patent/CN103846113B/en not_active Expired - Fee Related
- 2014-12-09 HK HK14112362.9A patent/HK1198962A1/en not_active IP Right Cessation
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2015067180A1 (en) * | 2013-11-06 | 2015-05-14 | 北京自由度科学机器有限公司 | Fully-automatic pipetting instrument and use thereof |
| WO2015139667A1 (en) * | 2014-03-21 | 2015-09-24 | 北京自由度科学机器有限公司 | Full-automatic pipetting station and application thereof |
| CN110361230A (en) * | 2018-04-09 | 2019-10-22 | 冷泉港生物科技股份有限公司 | Detect the automatic fluid injection method and device of monogenic inheritance disease |
| CN110361230B (en) * | 2018-04-09 | 2021-12-14 | 冷泉港生物科技股份有限公司 | Automatic liquid injection method and device for detecting monogenic genetic diseases |
| CN109142708A (en) * | 2018-09-02 | 2019-01-04 | 广州源起健康科技有限公司 | A kind of Full-automatic magnetic beads time-resolved fluorescence immunoassay instrument |
| CN109142708B (en) * | 2018-09-02 | 2023-01-24 | 广州源起健康科技有限公司 | Full-automatic magnetic bead time-resolved fluorescence immunoassay appearance |
| WO2022021377A1 (en) * | 2020-07-31 | 2022-02-03 | 杭州九洋生物科技有限公司 | Pipette and pipetting method |
Also Published As
| Publication number | Publication date |
|---|---|
| HK1198962A1 (en) | 2015-07-24 |
| CN103846113A (en) | 2014-06-11 |
| CN103846113B (en) | 2016-08-31 |
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Application publication date: 20140205 |