CN103536852A - Pharmaceutical composition for treating mental disease and use thereof - Google Patents
Pharmaceutical composition for treating mental disease and use thereof Download PDFInfo
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Abstract
The invention relates to the technical field of a traditional Chinese medicine, in particular to a pharmaceutical composition for treating a mental disease and use thereof for treating schizophrenia, depressive disorder or drug-induced obesity. The pharmaceutical composition comprises the following traditional Chinese medicinal materials or extracts thereof in parts by weight: 10-15 parts of processed rhizoma pinelliae, 10-12 parts of old arisaema cum bile, 15 parts of poria cocos, 15 parts of poria with hostwood, 10-15 parts of rhizoma cyperi, 10-15 parts of rhizoma acori graminei, 12-15 parts of radix curcumae, 10 parts of polygala tenuifolia, 20 parts of root of red-rooted salvia, 15-30 parts of spina date seed and 8-10 parts of coptis chinensis. The pharmaceutical composition disclosed by the invention has good effect on treatment of the schizophrenia by combining with sulpiride. The pharmaceutical composition disclosed by the invention has good effect on treatment of the depressive disorder, and does not generate the drug-induced obesity.
Description
[technical field]
The present invention relates to technical field of Chinese medicines, be specifically related to a kind of pharmaceutical composition for the treatment of mental sickness and its and be used for the treatment of the purposes in schizophrenia, depression or drug-induced obesity.
[background technology]
The performance of mental sickness is people's hyperpraxia, as not normal in the fluctuation of disturbance in thinking, emotion, and most patients are easily recurred, and the course of disease is longer.Mental sickness also can be by treatment, controlled and recovery from illness.Increase along with people's life, operating pressure, the mental sickness of depression and other symptom is very common, and just there is about 20,000,000 psychiatric patient in ，Jin China according to statistics, wherein schizophrenia is modal mental sickness, accounts for the more than half of principal characteristic mental sickness.The cause of disease of mental sickness is because the aspect performances such as the sensation that thalamus, brain dysfunction and pathological changes occur, memory, thinking, emotion, behavior are abnormal, under the domination of pathology psychology, psychiatric patient has the action behavior of committing suiside or attacking, injuring other people, to society, brings unsafe factor.The most of patients pulse condition stringy and rolling pulse of mental sickness, sliding number, thin and delicate or heavy weak unable, how because excessive thinking causes depression of liver-QI, temper is not raw, stagnation of QI expectorant knot, strongly fragrant heat-transformation of a specified duration, disturbs and the mind, undermines heart spleen.Treat and above-mentionedly mainly adopt with the following method at present as mental sickness such as schizophrenia, depressions: the one, with the method treatment of compacting, all take and calm, sleep peacefully medicine as main, can not eradicate disease, side effect is large; The 2nd, by reconciliation method treatment, spiritedness therapy, surgical therapy, acupuncture therapy, combination of Chinese and Western medicine Drug therapy, said method treatment time is long, and cure rate is low.
In addition, the medicine of long-term taking treatment mental sickness also can bring out obesity, after resisting mental disease medicine obesity may with intemperance of taking food, hypomotility, zang-fu organs qi movement is not smooth, lifting is out-of-sequence and weakness due to chronic disease all has relation, due to stagnation of QI due to depression of the liver, and dysfunction of the spleen in transportation, cause the phlegm-damp stasis of blood and amass into cream fat, gather and in body, form obesity.
[summary of the invention]
The object of the present invention is to provide a kind of pharmaceutical composition for the treatment of mental sickness, Adjunctive Treatment For Schizophrenia, Cure of depression are all had to preferably effect, the medicine of significantly alleviating because of long-term taking treatment mental sickness also can bring out obesity.
Object of the present invention can realize by following technical measures:
Treat a pharmaceutical composition for mental sickness, described pharmaceutical composition comprises that the Chinese crude drug of following weight portion or its extract form: 8～10 parts of 10～15 parts of Rhizoma Pinelliae Preparata, 10～12 parts of Arisaema Cum Biles, 15 parts, Poria, 15 parts of Poria cum Radix Pinis, 10～15 parts of Rhizoma Cyperis, 10～15 parts of Rhizoma Acori Graminei, 12～15 parts of Radix Curcumaes, 10 parts of Radix Polygalaes, 20 parts of Radix Salviae Miltiorrhizaes, 15～30 parts of Semen Ziziphi Spinosaes and Rhizoma Coptidis.
Preferably, for schizophrenic, described pharmaceutical composition also comprises that the Chinese crude drug of following weight portion or its extract form: 10～15 parts of Radix Et Rhizoma Rhei, 3～5 parts of succinums.Aforementioned pharmaceutical compositions can be assisted sulpiride treatment schizophrenia.
Preferably, for patients with depression, described pharmaceutical composition also comprises that the Chinese crude drug of following weight portion or its extract form: 30 parts of 10 parts of Radix Bupleuri (processed with vinegar), 10 parts of Fructus Aurantiis and Bulbus Liliies.
Preferably, for the drug-induced obesity of long-term taking resisting mental disease, described pharmaceutical composition also comprises that the Chinese crude drug of following weight portion or its extract form: 30 parts of 12 parts of Rhizoma Atractylodis, 12 parts of the Rhizoma Atractylodis Macrocephalaes, 10 parts of Fructus Aurantiis and Fructus Crataegi.
Preferably, described extract is alcohol extract, water extract or volatile oil.
Preferably, described pharmaceutical composition also comprises pharmaceutically acceptable adjuvant, and described pharmaceutical composition is prepared to tablet, capsule, electuary, pill, powder, suspensoid, powder, solution, drop or drop pill together with described adjuvant.
The present invention also provides the purposes of aforementioned pharmaceutical compositions in the medicine for the preparation of the drug-induced obesity for the treatment of schizophrenia, depression or long-term taking resisting mental disease on the other hand.Compared with prior art, beneficial effect of the present invention is, pharmaceutical composition of the present invention and sulpiride therapeutic alliance be schizoid has good effect; Pharmaceutical composition of the present invention has good effect to the treatment of depression; Pharmaceutical composition of the present invention can not produce medicine source property obesity.
[specific embodiment]
In order to make object of the present invention, technical scheme and advantage clearer, below in conjunction with the drawings and specific embodiments, the present invention is described in further detail.Should be appreciated that specific embodiment described herein, only in order to explain the present invention, is not intended to limit the present invention.
The present invention is directed to that psychiatric patient is many causes depression of liver-QI because of excessive thinking, temper is not raw, the symptom of stagnation of QI expectorant knot, to there is heat clearing and damp drying, activating QI to eliminate phlegm, the Rhizoma Coptidis WEIDANTANG component of stomach function regulating cholagogic efficacy combines with the fixed mad removing blood stasis soup component with the sensible effect of the thin stasis of blood, treatment mental sickness, wherein, described pharmaceutical composition is comprised of Chinese crude drug or its extract of following weight portion: 10～15 parts of Rhizoma Pinelliae Preparata, 10～12 parts of Arisaema Cum Biles, 15 parts, Poria, 15 parts of Poria cum Radix Pinis, 10～15 parts of Rhizoma Cyperis, 10～15 parts of Rhizoma Acori Graminei, 12～15 parts of Radix Curcumaes, 10 parts of Radix Polygalaes, 20 parts of Radix Salviae Miltiorrhizaes, 8～10 parts of 15～30 parts of Semen Ziziphi Spinosaes and Rhizoma Coptidis.
The pharmaceutical composition of the embodiment of the present invention mainly comprises the Rhizoma Coptidis WEIDANTANG components such as Rhizoma Pinelliae Preparata, Poria and Rhizoma Coptidis, and the fixed mad removing blood stasis soup component such as Rhizoma Cyperi, Rhizoma Acori Graminei, Radix Curcumae and Radix Salviae Miltiorrhizae, also coordinates other compositions such as Arisaema Cum Bile, Poria cum Radix Pini, Radix Polygalae and Semen Ziziphi Spinosae.
The pharmaceutical composition of the embodiment of the present invention all produces effect in treatment schizophrenia, depression and the drug-induced obesity of long-term taking resisting mental disease.
In a preferred version of the present invention, in order to improve schizoid therapeutic effect, also added the Chinese crude drug of following weight portion or its extract to form: 10～15 parts of Radix Et Rhizoma Rhei, 3～5 parts of succinums.
In another preferred version of the present invention, in order to improve the therapeutic effect of depression, also added the Chinese crude drug of following weight portion or its extract to form: 30 parts of 10 parts of Radix Bupleuri (processed with vinegar), 10 parts of Fructus Aurantiis and Bulbus Liliies.
In another preferred version of the present invention, in order to improve the therapeutic effect of the drug-induced obesity of long-term taking resisting mental disease, also added the Chinese crude drug of following weight portion or its extract to form: 30 parts of 12 parts of Rhizoma Atractylodis, 12 parts of the Rhizoma Atractylodis Macrocephalaes, 10 parts of Fructus Aurantiis and Fructus Crataegi.
Mental sickness of the present invention refers to schizophrenia well known to those skilled in the art and depression, described schizoid diagnostic criteria draft for: repeatedly there is verbal auditory ballucination in (1); (2) significantly loosening of association, splitting of thought, speech are discontinuous, or poverty of content of thought; (3) thought is inserted people, is withdrawn, is sent out, thinking interrupts, or forced thinking; (4) passive, controlled, or known clearly experience; (5) vain hope of primary delusion (comprising delusional perception, delusional mood) or other absurdities; (6) thinking logic perversion, morbid symbolic thinking, or neologism; (7) parathymia, or significantly apathy; (8) tension syndrome, strange behavior, or unwise behavior; (9) obvious hypobulia or shortage (according to < < psychiatry > >).Exclusion standard is for getting rid of except organic mental disorders, and psychoactive drug substance and non-addiction material caused by mental disorder.The compound Chinese Spirit Obstacles classification of schizoid all cases described in the embodiment of the present invention and diagnostic criteria the 3rd edition (CCMD-3), and the positive symptom and scale for the assessment of negative symptoms (PANSS) the scoring schizophrenic of >=60 minutes, get rid of serious physical disease, self inflicted injury, the tendency person that commits suiside and hurt sb.'s feelings, get rid of gestation and women breast-feeding their children.
It is low as main that described depression be take mental state, unbecoming with its situation, can, from depressed to extremely grieved, even occur numb.Can there is the psychotic symptoms such as hallucination, vain hope in severe patient.The anxiety of some case and mobility are intense very remarkable.
In pharmaceutical composition of the present invention, each drug introduction is as follows:
Rhizoma Pinelliae Preparata: be the Preparation process product of the Rhizoma Pinelliae, Preparation process method is as follows: get the clean Rhizoma Pinelliae, size separately, is soaked in water to interior without the dry heart, takes out; Another extracting liquorice is appropriate, decocts with water secondary, collecting decoction, pour in the lime liquor of making by suitable quantity of water, stir evenly, add the above-mentioned Rhizoma Pinelliae having soaked into, soak, stir 1～2 every day, and keep immersion pH value more than 12, yellow evenly to section, mouth is tasted micro-while having numb feeling in the tongue, takes out, clean, dry in the shade or dry, obtain, wherein, the clean Rhizoma Pinelliae of every 100kg, with Radix Glycyrrhizae 15kg, quicklime 10kg.The described Rhizoma Pinelliae is the tuber of the aroid Rhizoma Pinelliae (Pinellia ternata (Thunb) Breit.).There is drying dampness to eliminate phlegm, stopping nausea and vomiting by lowering the adverse flow of QI, the merit of dissolving lump and resolving mass.
Arisaema Cum Bile: be again Arisaema Cum Bile, concoct and form with Rhizoma Zingiberis Recens or bile for Rhizoma Arisaematis, concocting method is as follows: Arisaema Cum Bile is placed in clear water and is repeatedly floated to without after spicy sense, wear into fine powder; Separately with the assorted juice of elimination, be incorporated to the equivalent Fel Bovis seu Bubali that copper pot worries along, mix thoroughly with Rhizoma Arisaematis powder; Treat that bile absorbs completely, shine to after half-dried, enter in mortar, beat and, be cut into small pieces, weather exposure to without fishy smell for spending.Described Rhizoma Arisaematis is the tuber of aroid Gouzhua Banxia (Pinellia pedatisecta Schott).Arisaema Cum Bile has removing heat-phlegm, the effect of dispelling wind and relieving convulsion.
Poria: be On Polyporaceae Poria (Poria cocos(Schw.) Wolf) dry sclerotia.Function: diuretic medicine; Diuretics with the action of eliminating dampness.Cure mainly: dysuria; Edema distension; Phlegm retention cough with dyspnea; Vomiting;
Insufficiency of the spleen lack of appetite; Have loose bowels; Palpitation and restlessness; Insomnia forgetfulness; Seminal emission nebulousurine.
Poria cum Radix Pini: be Polyporaceae plant Poria (Poria cocos(Schw.) Wolf) the natural white portion of entertaining Radix Pini massonianae (i.e. " Lignum Poria ") in the middle of sclerotium.There is mind calming, calm the nerves, the effect of diuretic.Control the palpitation with fear of having a guilty conscience, forgetful, insomnia, infantile convulsion, dysuria.
Rhizoma Cyperi: be the dry rhizome of sedge dried tuber Cyperus rotundus L..The fragrant head grass of another name, later blue or green, passeris montani saturati head is fragrant.The tool resolving depression of regulating the flow of vital energy, the merit of menstruction regulating and pain relieving.For stagnation of QI due to depression of the liver, breast, the side of body, abdominal distention, menoxenia, distending pain of the breast.That the compatibility Radix Paeoniae Alba has is soothing the liver, yin nourishing, regulate the flow of vital energy, the effect of pain relieving.
Rhizoma Acori Graminei: be the rhizome of acorus gramineus araceae plant (Acorus gramineus).There is removing dampness appetizing, the eliminating phlegm of having one's ideas straightened out, the effect of refreshment Fructus Alpiniae Oxyphyllae.
Radix Curcumae: be the tuber of zingiberaceous plant Radix Curcumae Curcuma aromatica Salisb..There is promoting blood circulation and stopping pain, promoting QI circulation for relieving depression, the removing heat from blood that clears away heart-fire, the effect of promoting the function of the gallbladder to alleviate jaundice.
Radix Polygalae: be the dry root of milk wort Radix Polygalae Polygala tenuifolia Willd..There is the Fructus Alpiniae Oxyphyllae of calming the nerves, eliminate the phlegm, the effect of detumescence.Cure mainly insomnia and dreamful sleep, the diseases such as forgetful palpitation with fear.
Radix Salviae Miltiorrhizae: be the dry root and rhizome of dicotyledon Labiatae salvia Radix Salviae Miltiorrhizae Salvia miltiorrhizaBge.The effect with promoting blood circulation to restore menstrual flow, evacuation of pus granulation promoting.
Semen Ziziphi Spinosae: for the seed of Rhamnaceae plant Ziziphi Spinosae Ziziphus jujuba var spinosa (Bunge) Hu, collect pit after fruit maturation, remove sarcocarp and nucleocapsid, take out seed, dry.Have nourishing the liver, mind calming, calms the nerves, the effect of arresting sweating.
Rhizoma Coptidis: be the dry rhizome of cohosh Rhizoma Coptidis (Coptis chinensis Franch.), Coptis deltoidea C.Y.Cheng et Hsiao (Coptis deltoidea C.Y.Cheng et Hsiao) and Coptis Teeta Wall (Coptis teeta Wall.).There is heat clearing and damp drying, the effect of eliminating fire and detoxication.
Radix Et Rhizoma Rhei: be the dry root and rhizome of polygonum rheum palmatum Rheum palmatum L., Rheum tanguticum Rheum tanguticum Maxim.ex Balf. or Rheum officinale Rheum officinale Baill..There is purging heat and dredging bowels, removing pathogenic heat from blood and toxic substance from the body, the effect of eliminating blood stasis and inducing menstruation.
Succinum: there is calmness, diuresis, the effect of invigorating blood circulation.
Radix Bupleuri (processed with vinegar): concoct and form for Radix Bupleuri: first get Radix Bupleuri sheet and add quantitative rice vinegar to mix (every 100kg Radix Bupleuri agreement that contracts a film or TV play to an actor or actress is with rice vinegar 20kg) thoroughly, slightly moistening, after vinegar is sucked, puts to fry and process in container, and by slow fire heating, fried dry, taking-up is dried in the air cold.The bitter temperature of vinegar nature and flavor, master enters Liver Channel blood system, and has convergence, removing toxic substances, eliminating stasis to stop pain, the effect of taste masking, therefore vinegar method for making is used for dispersing the stagnated live-QI to relieve the stagnation of QI, eliminating stasis to stop pain, captures the medicine of relieving oedema or abdominal distension through diuresis or purgation.It rises loose property mitigation Radix Bupleuri (processed with vinegar), and the effect of Shugan Zhitong strengthens, and for the distending pain over the hypochondrium of stagnation of QI due to depression of the liver, the diseases such as stomachache have good therapeutic effect.Described Radix Bupleuri is samphire Radix Bupleuri (Bupleurum chinense DC.), with root, is used as medicine.
Fructus Aurantii: be the dry immature fruit of rutaceae Citrus aurantium Linn. Citrus aurantium L. and variety thereof.There is dispelling the stagnated QI, row expectorant, the effect of removing food stagnancy.
Bulbus Lilii: be the dry meat scale leaf of liliaceous plant tiger lily Lilium lancifolium Thunb., Bulbus Lilii Lilium brownii F.E.Brown var.viridulum Baker or Bulbus lilii concoloris Bulbus Lilii (Lilium tenuifolium) Lilium pumilum DC..There is nourishing YIN and moistening the lung, the effect of clearing away heart-fire for tranquillization.For deficiency of YIN chronic cough, sputum mixed with blood, fidgets due to deficiency palpitation with fear, insomnia and dreamful sleep, absentminded.
Fructus Crataegi: for the fruit of rosaceous plant Fructus Crataegi (Crataegus pinnatifida), take off, remove impurity, section is dried.Have removing food stagnancy, clots absorbing, changes stagnant effect.
Rhizoma Atractylodis: be the dry rhizome of feverfew Atractylodes lancea (Thunb.) DC. Atractylodes lancea (Thunb.) DC. or Atractylis chinensis Atractylodes chinensis (DC.) Koidz..Cure mainly: air making-up and spleen enlivening, dampness diuretic, hidroschesis, antiabortive.Clinical practice: for deficiency of spleen-QI and stomach-QI, transporting is unable, anorexia and loose stool, distension and fullness in the abdomen, the cards such as the soft Mental fatigue of limb; For insufficiency of the spleen water retention, and be that water is wet, phlegm retention, edema, dysuria; For deficiency of the spleen causing weakness of QI, and the not solid hyperhidrosis of flesh table; For deficiency of the spleen causing weakness of QI, frequent fetal movement.Have drying damp and strengthening spleen, the effect of wind-damp dispelling.
The Rhizoma Atractylodis Macrocephalae: be the dry rhizome of feverfew Rhizoma Atractylodis Macrocephalae Atractylodes macrocephala Koidz..There is invigorating the spleen and replenishing QI, invigorating the spleen and regulating the stomach, dampness diuretic, reduces phlegm, and hidroschesis is antiabortive, increases the effect of appetite.
Table 1 is depicted as take the concrete content of each component in the pharmaceutical composition that Adjunctive Treatment For Schizophrenia is object:
Table 1
Table 2 is depicted as take the concrete content of each component in the pharmaceutical composition that Cure of depression is object:
Table 2
Table 3 is depicted as take the concrete content of each component in the pharmaceutical composition that obesity that medicine brings out is object:
Table 3
Application examples 1
Adopt the pharmaceutical composition Adjunctive Treatment For Schizophrenia of embodiment of the present invention 1-6
case selection
From 2006-2012 Nian，Cong the court, select 78 routine schizophrenics, be divided into experimental group and matched group.
Experimental group: 39 examples adopt sulpiride associating embodiment of the present invention 1-6(according to the situation of the state of an illness, the consumption of Chinese medicine to be adjusted) pharmaceutical composition, 28.23 ± 9.75 years old mean age, average course of disease 5.92 ± 4.39 months.
Matched group: 39 examples adopt common haloperidol to treat, 27.65 ± 10.37 years old mean age, average course of disease 6.17 ± 5.73 months.
diagnostic criteria
The compound Chinese Spirit Obstacles classification of schizoid all cases described in the embodiment of the present invention and diagnostic criteria the 3rd edition (CCMD-3), and the positive symptom and scale for the assessment of negative symptoms (PANSS) the scoring schizophrenic of >=60 minutes, get rid of serious physical disease, self inflicted injury, the tendency person that commits suiside and hurt sb.'s feelings, get rid of gestation and women breast-feeding their children.
therapeutic Method
Experimental group: press every dose of decocting twice of proportioning (every part for 1g) of embodiment 1-6, take medicinal liquid 400ml, each oral 200ml, 2 times on the one, 1 dose of general every day, 2 doses of serious symptom the first case every days; Within 30 days, be a course for the treatment of, observe altogether 2 courses for the treatment of; Sulpiride initial dose 0.4g/ day, the next day dosing 0.2g/ day, add to 0.8g～1.2g/ day in two weeks; Before treatment and after treatment, within 8 weeks, carry out the evaluation that PANSS total points and each factor are divided, before treatment and finish rear inspection electrocardiogram, routine blood test, liver function and renal function the course for the treatment of.
Matched group: haloperidol group is to haloperidol initial dose 6mg/ day, the next day dosing 4mg/ day, add to 20～40mg/ day in two weeks.
treatment standard and result
Recovery from illness: symptom disappears completely or substantially disappears, and insight exists;
Effective: symptom disappears substantially, part insight exists;
Progressive: symptom alleviates to some extent, part insight exists;
Invalid: symptom has no to alleviate, and insight does not recover.
therapeutic outcome
Experimental group: 13 examples of fully recovering, effective 15 examples, progressive 7 examples, invalid 4 examples, total effective rate 89.1%;
Matched group: 8 examples of fully recovering, effective 12 examples, progressive 14 examples, invalid 5 examples, total effective rate 87.1%.
The cure rate of experimental group and obvious effective rate are obviously better than matched group (P<0.01).The pharmaceutical composition of embodiment 1-embodiment 6 has significant effect on Adjunctive Treatment For Schizophrenia.
Application examples 2
Adopt the medicine composite for curing depression of embodiment of the present invention 7-12
case selection
From 1990-2012 Nian，Cong the court, select 60 routine schizophrenics, be divided into experimental group and matched group.
Experimental group: 30 examples adopt embodiment of the present invention 7-12(according to the situation of the state of an illness, the consumption of Chinese medicine to be adjusted) pharmaceutical composition, 33 ± 9 years old mean age, average course of disease 5.92 ± 4.39 months.
Matched group: 30 examples adopt common tricyclic antidepressant to treat, 35 ± 10 years old mean age.
diagnostic criteria
The compound Chinese Spirit Obstacles classification of all cases and the diagnostic criteria the 3rd edition (CCMD-3) of the depression described in the embodiment of the present invention, it is low as main that symptom standard be take mental state, this symptom continues more than 2 weeks, and has following 4 at least: (1) hebetude, the happy sense of nothing; (2) energy goes down or tired sense; (3) psychomotor activity is sluggish or intense; (4) too low, the self-accusation of self evaluation, or has feeling of guilt; (5) association difficulty or conscious elaborative faculty decline; (6) repeatedly there is the thought of wanting to die or have suicide, autolesionism; (7) sleep disorder, as insomnia, early awakening, or hypersomnia; (8) appetite depression or body weight obviously alleviate; (9) hyposexuality.
therapeutic Method
Experimental group: press every dose of decocting twice of proportioning (every part is 1g) of embodiment 8-14,1 dose of every day, decocting twice, gets decocting liquid 400ml, and before sleeping, clothes head is decocted, and takes two next day and decocts.Within 2 weeks, be a course for the treatment of, take continuously 1～2 course for the treatment of;
Matched group: tricyclic antidepressant, every day 2 times, continuously 2-4 week.
treatment standard
Recovery from illness: transference cure, emotion is normal;
Effective: symptom disappears substantially, emotion is basicly stable;
Effective: symptom alleviates, partial symptoms disappears substantially, and emotion is basicly stable;
Invalid: symptom, emotion are all without improving.
therapeutic outcome
Experimental group: 5 examples of fully recovering, effective 7 examples, effective 13 examples, invalid 5 examples, total effective rate 83%;
Matched group: 3 examples of fully recovering, effective 5 examples, effective 17 examples, invalid 5 examples, total effective rate 83%.
The cure rate of experimental group and obvious effective rate are obviously better than matched group (P<0.01).The pharmaceutical composition of embodiment 8-embodiment 14 has significant effect on Cure of depression.
Application examples 3
Adopt the drug-induced obesity of medicine composite for curing long-term taking resisting mental disease of embodiment of the present invention 13-18
case selection
From 1996-2012 Nian，Cong the court, select 60 routine schizophrenics, male's 32 examples wherein, women's 28 examples; Following 2 examples of 20 years old age, 21～40 years old 32 example, 41～50 years old 20 example, 51 years old above 6 example is the course of disease the shortest January, the longest 18 years; In 60 examples, diagnosis 40 Cases of Schizophrenia, all the other are affective disorder, reactive disorder etc.; In 60 routine patients, take risperidone 12 examples, clozapine 30 examples, sulpiride 6 examples, amitriptyline 2 examples, drug combination 10 examples.Be divided at random experimental group and matched group.
Experimental group: 30 examples are Taking Antipsychotics on time, takes embodiment of the present invention 15-21(simultaneously and according to the situation of the state of an illness, the consumption of Chinese medicine is adjusted) pharmaceutical composition, 40.23 ± 9.75 years old mean age, average course of disease 9.8 ± 2.1 years.
Matched group: 30 examples are Taking Antipsychotics on time, 47.65 ± 10.37 years old mean age, average course of disease 9.17 ± 3.73 months.
diagnostic criteria
Schizoid all cases described in the embodiment of the present invention causes that because taking resisting mental disease medicine body weight increases, and surpasses normal type standard more than 20%.
therapeutic Method
Experimental group: press every dose of decocting twice of proportioning (every part is 1g) of embodiment 13-18, take medicinal liquid 400ml, each oral 200ml, 2 times on the one, 1 dose of general every day; Within 30 days, be a course for the treatment of, observe altogether 2 courses for the treatment of; The antipsychotic drug that patient took is originally taken as usual.
Matched group: the antipsychotic drug that patient took is originally taken as usual.
treatment standard and result
Effective: to lose weight the 3kg/ month;
Effective: to lose weight 1～2kg/ month;
Invalid: to lose weight the not enough 1kg/ month.
therapeutic outcome
Experimental group: effective 10 examples, effective 14 examples, invalid 6 examples, total effective rate 80%;
Matched group: invalid 30 examples.
The total effective rate of experimental group is obviously better than matched group (P<0.01).Embodiment 15-embodiment 21 has significant effect in the drug-induced obesity for the treatment of long-term taking resisting mental disease.
The above the specific embodiment of the present invention, does not form limiting the scope of the present invention.Various other corresponding changes and distortion that any technical conceive according to the present invention is made, all should be included in the protection domain of the claims in the present invention.
Claims (10)
1. a pharmaceutical composition for the treatment of mental sickness, it is characterized in that, described pharmaceutical composition comprises that the Chinese crude drug of following weight portion or its extract form: 8～10 parts of 10～15 parts of Rhizoma Pinelliae Preparata, 10～12 parts of Arisaema Cum Biles, 15 parts, Poria, 15 parts of Poria cum Radix Pinis, 10～15 parts of Rhizoma Cyperis, 10～15 parts of Rhizoma Acori Graminei, 12～15 parts of Radix Curcumaes, 10 parts of Radix Polygalaes, 20 parts of Radix Salviae Miltiorrhizaes, 15～30 parts of Semen Ziziphi Spinosaes and Rhizoma Coptidis.
2. pharmaceutical composition according to claim 1, is characterized in that, described pharmaceutical composition also comprises that the Chinese crude drug of following weight portion or its extract form: 10～15 parts of Radix Et Rhizoma Rhei, 3～5 parts of succinums.
3. pharmaceutical composition according to claim 1, is characterized in that, described pharmaceutical composition also comprises that the Chinese crude drug of following weight portion or its extract form: 30 parts of 10 parts of Radix Bupleuri (processed with vinegar), 10 parts of Fructus Aurantiis and Bulbus Liliies.
4. pharmaceutical composition according to claim 1, is characterized in that, described pharmaceutical composition also comprises that the Chinese crude drug of following weight portion or its extract form: 30 parts of 12 parts of Rhizoma Atractylodis, 12 parts of the Rhizoma Atractylodis Macrocephalaes, 10 parts of Fructus Aurantiis and Fructus Crataegi.
5. pharmaceutical composition according to claim 2, is characterized in that, described pharmaceutical composition also comprises sulpiride.
6. according to the pharmaceutical composition described in claim 1 to 4 any one, it is characterized in that, described extract is alcohol extract, water extract or volatile oil.
7. according to the pharmaceutical composition described in claim 1 to 4 any one, it is characterized in that, described pharmaceutical composition also comprises pharmaceutically acceptable adjuvant, and described pharmaceutical composition is prepared to tablet, capsule, electuary, pill, powder, suspensoid, powder, solution, drop or drop pill together with described adjuvant.
8. the purposes of pharmaceutical composition claimed in claim 1 in the medicine for the preparation for the treatment of schizophrenia, depression or drug-induced obesity.
9. the purposes of pharmaceutical composition claimed in claim 3 in the medicine for the preparation of Cure of depression.
10. the purposes of pharmaceutical composition claimed in claim 4 in the medicine for the preparation of the drug-induced obesity for the treatment of long-term taking resisting mental disease.
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Cited By (6)
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| CN104096182A (en) * | 2014-07-28 | 2014-10-15 | 高思山 | Traditional Chinese medicine composition for treating forced laughter or crying after stroke |
| CN104474426A (en) * | 2014-12-09 | 2015-04-01 | 张祺 | Drug for treating schizophrenia |
| CN104800761A (en) * | 2015-04-30 | 2015-07-29 | 唐国萍 | Traditional Chinese medicine composition for treating postnatal depression |
| CN105641148A (en) * | 2016-02-26 | 2016-06-08 | 辽宁中医药大学 | Application of bitter orange volatile oil extract in preparation of antidepressant drug |
| CN107569646A (en) * | 2016-06-29 | 2018-01-12 | 殷学臣 | It is a kind of to treat insomnia, depression, the Chinese medicine preparation of mental disease |
| CN108653684A (en) * | 2018-08-16 | 2018-10-16 | 赵树森 | A kind of Chinese medicine composition and its preparation method and application |
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104096182A (en) * | 2014-07-28 | 2014-10-15 | 高思山 | Traditional Chinese medicine composition for treating forced laughter or crying after stroke |
| CN104474426A (en) * | 2014-12-09 | 2015-04-01 | 张祺 | Drug for treating schizophrenia |
| CN104800761A (en) * | 2015-04-30 | 2015-07-29 | 唐国萍 | Traditional Chinese medicine composition for treating postnatal depression |
| CN105641148A (en) * | 2016-02-26 | 2016-06-08 | 辽宁中医药大学 | Application of bitter orange volatile oil extract in preparation of antidepressant drug |
| CN105641148B (en) * | 2016-02-26 | 2019-09-17 | 辽宁中医药大学 | Application of the Fructus Aurantii volatile oil extract as preparation antidepressant |
| CN107569646A (en) * | 2016-06-29 | 2018-01-12 | 殷学臣 | It is a kind of to treat insomnia, depression, the Chinese medicine preparation of mental disease |
| CN108653684A (en) * | 2018-08-16 | 2018-10-16 | 赵树森 | A kind of Chinese medicine composition and its preparation method and application |
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Application publication date: 20140129 |