CN103535385B - Plant extract and synergist contained antimicrobial composition - Google Patents
Plant extract and synergist contained antimicrobial composition Download PDFInfo
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- CN103535385B CN103535385B CN201310511646.1A CN201310511646A CN103535385B CN 103535385 B CN103535385 B CN 103535385B CN 201310511646 A CN201310511646 A CN 201310511646A CN 103535385 B CN103535385 B CN 103535385B
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Abstract
The invention discloses a plant extract and synergist contained antimicrobial composition. The composition contains a plant extract (A), a synergist (B), a mildew preventive (C), an antiseptic (D) and a solvent (E). The composition disclosed by the invention has a good inhibiting effect on bacteria and fungi (molds nod saccharomycetes); through the synergistic effect of all the components, the consumption of the traditional chemical antiseptic IPBC (Iodopropynyl Butylcarbamate) or nipagin esters is remarkably reduced, the safety in using the composition is improved, the irritation is reduced, and the possible risks are reduced. Meanwhile, the antiseptic is compounded in the composition, so that the antibacterial spectrum of an antiseptic system of the composition is effectively expanded, and the bacteriostatic ability is enhanced.
Description
Technical field
The present invention relates to a kind of antimicrobial compositions containing plant extracts and synergetic effect additive, be mainly used in the antisepsis and sterilization of microorganism in personal care articles, household articles for washing and wet tissue.
Background technology
In the products such as personal care articles, household articles for washing and wet tissue, common microorganism mainly contains bacterium, fungi (yeast and mold), in order to prevent the Growth and Reproduction of these microorganisms, generally all needs to add a certain amount of anticorrosion and bactericidal agent.These anticorrosion and bactericidal agents will all have good sterilization and antibacterial effect to bacterium, fungi (yeast and mold), also will have less excitant, higher safety simultaneously and meet the requirement of laws and regulations.
Anticorrosion and bactericidal agent, in the process used, in order to increase the broad spectrum activity of its suppression microbicide, generally all needing to carry out suitable composite, using by the preservative of directed toward bacteria with for after the mould inhibitor combination of fungi (yeast and mold).
In recent years, the use of chemosynthesis class anticorrosion and bactericidal agent is more and more subject to the restriction of more laws and regulations, in addition the requirement of consumer to product is also more and more higher, and some plant extractss start extensively approved and use, can some or all of alternative chemosynthesis class anticorrosion and bactericidal agent.
Traditional mould inhibitor mainly contains nipagin esters series and iodine propilolic alcohol butyl mephenesin Carbamate (hereinafter referred to as IPBC) etc., and in use procedure in recent years, these kinds are also quite disputed on, and occur some hot issues relevant to safety.Although if IPBC is the best a kind of mould inhibitor of effect, usually only need several ppm just can play extraordinary anti-mold effect; But because its amount of iodine is higher, the restriction that regulation uses it is also more and more stricter, particularly in the application aspect of infant's product, all specify in the cosmetics regulation of the regulatory affairs (Directive76/768/EEC) before European Union and up-to-date execution [Regulation(EC) No1223/2009], IPBC can not be used for the baby formula (bath article and shampoo except) of less than three years old, also be not used in (contact large area skin) body dew and body frost product, in consumption, also receive strict restriction.Owing to having certain estrogen effect, the safety of nipagin esters product series also receives many queries, just propagates its belief on a large scale in the middle of manufacturer and consumer without the concept of nipagin esters (paraben-free).
For these reasons, for evading various possibility risk, all try one's best in daily chemical products particularly infant's product consumption reducing IPBC and nipagin esters or the protective system not adopting the type.
China Patent Publication No. CN102480944A, publication date on 05 30th, 2012, disclose a kind of composition containing anhydro sorbitol list caprylate and anti-microbial active matter, said composition contains multiple bacteriostatic activity thing, as organic acid and salt, formaldehyde sustained release, nipagin esters and salt thereof, and anhydro sorbitol list caprylate.China Patent Publication No. CN101951779A, No. 19, publication date 2011 01 month, disclose a kind of antimicrobial compositions, said composition contains water-alcohol solvent system and the cationic antimicrobial agent of the rudimentary alcohol and water of C2-C5.
The invention provides a kind of antimicrobial compositions containing plant extracts, synergetic effect additive and anticorrosion and bactericidal agent, pass through synergistic function, composite Determination of Preservatives simultaneously, to reach the broad-spectrum antibacterial effect to bacterium and fungi, reduce the consumption of IPBC, both reach antiseptic effect, also reduce the negative effect of IPBC to product.
Summary of the invention
The invention provides a kind of antimicrobial compositions containing plant extracts, synergetic effect additive, mould inhibitor, anticorrosion and bactericidal agent.Said composition can not only meet the products such as personal-care supplies, household articles for washing and wet tissue to the control overflow of microorganism, the safety in utilization of the products such as personal-care supplies, household articles for washing and wet tissue can also be improved, reduce the consumption of IPBC or nipagin esters, reduce the possible risk of IPBC and nipagin esters.Said composition can reach the control of microorganisms effect that IPBC is used alone, and can substitute the anticorrosion and bactericidal agent product that other contains IPBC and nipagin esters.
The antimicrobial compositions of plant extracts contained by the present invention and synergetic effect additive contains:
A) plant extracts;
B) synergetic effect additive;
C) mould inhibitor;
D) anticorrosion and bactericidal agent;
E) solvent.
A in described composition) plant extracts comprises the mixture of a kind of in thyme linaloe oil, Honegsukle flower P.E, licorice, Radix et Caulis Opuntiae Dillenii extract or at least two kinds.
B in described composition) synergetic effect additive comprises the mixture of a kind of in lauric monoglyceride, 1,2-butanediol, 1,2-pentanediol, 1,2-hexylene glycol, 1,2-ethohexadiol, 1,2-decanediol, benzyl carbinol, Sensiva SC50 or at least two kinds;
C in described composition) mould inhibitor comprises the mixture of a kind of in iodine propilolic alcohol butyl mephenesin Carbamate (IPBC), methyl hydroxybenzoate, ethylparaben, propylben, butyl hydroxybenzoate, nipalgin isopropyl ester, iso-butyl p-hy-droxybenzoate or at least two kinds.
D in described composition) anticorrosion and bactericidal agent comprises the mixture of a kind of in benzethonium chloride, triclosan, Phenoxyethanol, imidazolidinyl urea, diazonium imidazolidinyl urea, 1,3-diformazan methylol dimethyl hydantion (english abbreviation DMDMH), methylisothiazolinone, methylchloroisothiazandnone or at least two kinds;
E in described composition) solvent comprises a kind of in 1,2-PD, polyethylene glycol (hereinafter referred to as PEG), water or at least two kinds mixture.
The preferred < 12 of the degree of polymerization of described PEG.PEG(8) degree of polymerization of expression PEG is 8.
Wherein, A in described composition) weight percentage of plant extracts is 1.0 ~ 30%, is preferably 5 ~ 25%, most more preferably is 10 ~ 20%.
B in described composition) weight percentage of synergetic effect additive is 5 ~ 80%, is preferably 10 ~ 60%, is more preferably 15 ~ 40%.
C in described composition) weight percentage of mould inhibitor is 0.5 ~ 25%, is preferably 2 ~ 20%, is more preferably 3 ~ 10%.
D in described composition) weight percentage of anticorrosion and bactericidal agent is 0.5 ~ 40%, is preferably 5 ~ 30%, is more preferably 8 ~ 20%.
E in described composition) weight percentage of solvent is 5 ~ 90%, is preferably 15 ~ 70%, is more preferably 20 ~ 60%.
A in described composition) plant extracts buyable commercial prod or by conventional method preparation (can be liquid or solid).Described plant extracts General Requirements is: content >=5% of Thymol in thyme linaloe oil; Content >=2% of Honegsukle flower P.E Content of Chlorogenic Acid; Content >=5% of glycyrrhizic acid in licorice; Content >=1% of brass class chemicals in Radix et Caulis Opuntiae Dillenii extract.
The present composition can adopt this area conventional method preparation; Or preparation method is: 1. by B) synergetic effect additive and E) after solvent, be warming up to 40 ~ 50 DEG C, add C) mould inhibitor, stir until dissolution of solid is complete; 2. D is added after being cooled to 20 ~ 35 DEG C) anticorrosion and bactericidal agent and A) plant extracts, continues to stir until evenly; 3. filter.
Composition of the present invention all has good inhibitory action to bacterium, fungi (yeast and mold).By plant extracts, synergetic effect additive, mould inhibitor, anticorrosion and bactericidal agent synergy, significantly reduce the consumption of traditional chemical type anticorrosion and bactericidal agent IPBC or nipagin esters series, improve said composition safety in utilization, reduce excitant, reducing may risk.Meanwhile, composite anticorrosion and bactericidal agent in composition, effectively expands the antimicrobial spectrum of composition antisepsis and sterilization system, enhances bacteriostasis.
The microbial disinfection that described composition can be used in the products such as personal care articles, household articles for washing or wet tissue is anticorrosion.
Personal care articles of the present invention, household articles for washing, wet tissue, comprise all products in this area, as cream frost, emulsion, mildy wash, shampoo, shower cream, hand cleanser, toothpaste, toner, washing agent, liquid detergent, leather nursing product, wet tissue series products etc.
Embodiment
The following examples contribute to the present invention of those skilled in the art's comprehend, but do not limit the present invention in any way.
Embodiment 1
Table 1. antimicrobial compositions is respectively filled a prescription inventory (% by weight)
Embodiment 2
Measured the minimum inhibitory concentration (MIC value) of 1#-8# composition in embodiment 1 table 1 by spread plate (to mould, saccharomycete) and dilution cultivation (to bacterium), the results are shown in Table 2.
Table 2.MIC value (ppm)
As can be seen from Table 2: 1# and 5# formula is contrast sample, 5# formula is after interpolation synergist and plant extracts, its MIC value significantly reduces, as dropped to 500ppm to colibacillary MIC from 650ppm, the MIC value of dialogue candidiasis drops to 10ppm from 100ppm, and other bacterial classification also has similar effect.3# and 8# formula is contrast sample, 3# formula is after interpolation synergist and plant extracts, equivalent or in a slight decrease to the MIC value of aspergillus niger, penicillium expansum and candida albicans bacterium, for candida albicans bacterium, in 3# and 8# formula, the active quantities of IPBC is respectively 2.0% × 70ppm and 1.0% × 70ppm; Reach same fungistatic effect, after interpolation synergist and plant extracts, the consumption of IPBC can be reduced.
Embodiment 3
The product of the present invention's " antimicrobial compositions " can be used in personal care articles, comprises rinse-off products (as mildy wash, shampoo, shower cream, hand cleanser, toothpaste etc.) and resident type product (as cream frost, emulsion, toner etc.); Also can be used for household articles for washing (as washing agent, liquid detergent, leather nursing liquid, floor wax polish, kitchen cleaning agent etc.); Also can be used in all kinds of wet tissue.
The product of table 3. containing the present invention's " antimicrobial compositions "
" antimicrobial compositions " numbering and formula are with embodiment 1.The addition of data representation this kind of antimicrobial compositions in various product (personal care articles, household articles for washing or wet tissue) in form.
Claims (12)
1. the antimicrobial compositions containing plant extracts and synergetic effect additive, is characterized in that, described composition by:
A) weight percentage is the plant extracts of 1.0 ~ 30%;
B) weight percentage is the synergetic effect additive of 5 ~ 80%;
C) weight percentage is the mould inhibitor of 0.5 ~ 25%;
D) weight percentage is the anticorrosion and bactericidal agent of 0.5 ~ 40%;
E) weight percentage is the solvent composition of 5 ~ 90%;
A in described composition) plant extracts comprises the mixture of a kind of in thyme linaloe oil, Honegsukle flower P.E, licorice, Radix et Caulis Opuntiae Dillenii extract or at least two kinds;
B in described composition) synergetic effect additive comprises the mixture of a kind of in lauric monoglyceride, 1,2-butanediol, 1,2-pentanediol, 1,2-hexylene glycol, 1,2-ethohexadiol, 1,2-decanediol, benzyl carbinol, Sensiva SC50 or at least two kinds.
2. composition according to claim 1, it is characterized in that, C in described composition) mould inhibitor comprises the mixture of a kind of in iodine propilolic alcohol butyl mephenesin Carbamate, methyl hydroxybenzoate, ethylparaben, propylben, butyl hydroxybenzoate, nipalgin isopropyl ester, iso-butyl p-hy-droxybenzoate or at least two kinds.
3. composition according to claim 1, it is characterized in that, D in described composition) anticorrosion and bactericidal agent comprises the mixture of a kind of in benzethonium chloride, triclosan, Phenoxyethanol, imidazolidinyl urea, diazonium imidazolidinyl urea, DMDMH, methylisothiazolinone, methylchloroisothiazandnone or at least two kinds.
4. composition according to claim 1, is characterized in that, E in described composition) solvent comprises the mixture of a kind of in 1,2-PD, polyethylene glycol, water or at least two kinds.
5. composition according to claim 4, is characterized in that, the degree of polymerization < 12 of described polyethylene glycol.
6., according to the arbitrary described composition of claim 1-4, it is characterized in that, A in described composition) weight percentage of plant extracts is 10 ~ 20%.
7., according to the arbitrary described composition of claim 1-5, it is characterized in that, B in described composition) weight percentage of synergetic effect additive is 15 ~ 40%.
8., according to the arbitrary described composition of claim 1-4, it is characterized in that, C in described composition) weight percentage of mould inhibitor is 3 ~ 10%.
9., according to the arbitrary described composition of claim 1-4, it is characterized in that, D in described composition) weight percentage of anticorrosion and bactericidal agent is 8 ~ 20%.
10., according to the arbitrary described composition of claim 1-4, it is characterized in that, E in described composition) weight percentage of solvent is 20 ~ 60%.
11. are used for the purposes of personal care articles, household articles for washing or wet tissue according to the arbitrary described composition of claim 1-10.
12. 1 kinds of personal care articles, household articles for washing or wet tissues containing the arbitrary described composition of claim 1-10.
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