CN112586502A - Disinfectant suitable for high-temperature and high-pressure spray disinfection pipeline and disinfection composition containing disinfectant - Google Patents
Disinfectant suitable for high-temperature and high-pressure spray disinfection pipeline and disinfection composition containing disinfectant Download PDFInfo
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- CN112586502A CN112586502A CN202011502174.XA CN202011502174A CN112586502A CN 112586502 A CN112586502 A CN 112586502A CN 202011502174 A CN202011502174 A CN 202011502174A CN 112586502 A CN112586502 A CN 112586502A
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- disinfectant
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
- A01N43/50—1,3-Diazoles; Hydrogenated 1,3-diazoles
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N31/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic oxygen or sulfur compounds
- A01N31/02—Acyclic compounds
Abstract
The invention discloses a disinfectant suitable for high-temperature and high-pressure spray disinfection pipelines and a disinfection composition containing the disinfectant. The disinfectant of the scheme of the invention can better resist wear of a high-temperature high-pressure spray disinfection pipeline, can be better gasified at high temperature to form atomized particles with moderate particle size, can be better carbonized to form smoke-shaped particles, and is sprayed out from the mouth of the high-temperature high-pressure spray disinfection pipeline, so that pipeline blockage is not easy to occur. The composition also includes a synergist. The disinfectant of the scheme of the invention can form molecular nano spray by compounding with the synergist, increase the smoke yield and indicate the dissolution condition of the disinfectant; the disinfection composition can be more uniformly diffused to any corner in a disinfection space, and can be durably suspended in the air for disinfection for a plurality of hours; meanwhile, the composition can kill various viruses and pathogenic microorganisms (such as escherichia coli, bacillus subtilis, staphylococcus aureus and the like); is particularly suitable for killing microorganisms in livestock breeding places.
Description
Technical Field
The invention relates to the technical field of disinfection, in particular to a disinfectant suitable for high-temperature and high-pressure spray disinfection pipelines and a disinfection composition containing the disinfectant.
Background
With the development of society and the progress of human beings, the air environment problem is concerned. Pollution and control of the environment have become one of the concerns of the scientific community, the public and legislation. Microbial contamination is one of the environmental pollutions and also the source of the main infectious diseases. The microorganisms can cause the spread of human and animal and plant diseases, and particularly, in recent years, the prevalence and outbreak of some large public health events, such as COVID-19, avian influenza, swine fever and the like, are related to microbial contamination. Especially, the indoor pollution is increased in recent years, and the health and economic development of human beings are threatened.
In indoor public places with intensive people flow and intensive animal husbandry breeding places, the space is relatively closed, the air circulation is poor, viruses are easily concentrated, and the propagation speed of bacteria is high, so that the space sterilization is needed. Space disinfection refers to a process of eliminating or killing pathogenic microorganisms on the body surface, the space where the body surface is located and related articles by a physical, chemical or biological method. The purpose of disinfection is to eliminate pathogenic microorganisms or cut off the transmission path, prevent and control the occurrence and transmission speed of infectious diseases, and is an important measure for preventing and extinguishing the infectious diseases. The disinfection methods commonly used in indoor places include spraying, sprinkling, fumigation, flame, ultraviolet methods, and the like. The traditional spraying method is to dilute the disinfectant by several times and then spray the diluted disinfectant upwards in an atomizing manner, so that the disinfectant can be uniformly suspended in the air or uniformly covered in public places to achieve the aim of thorough disinfection.
A high-temperature high-pressure spray disinfection method (such as a disinfection spraying device disclosed in patent application document CN 109821049A) is a spray disinfection technology emerging in recent years, and is characterized in that a disinfectant is gasified at high temperature, and then the gasified disinfectant is sprayed out under high pressure to form smoke-shaped particles at a nozzle, wherein the atomized particles are small and can be suspended in the air for a long time, and meanwhile, a large amount of solvent is not required for dilution, so that the disinfection effect is good, the humidity is lower, and the environment in a disinfected farm is more comfortable. However, the method not only requires that the disinfectant not be easily decomposed at high temperature, but also can achieve better atomization and dispersion effects during use. In the prior art, quaternary ammonium salt disinfectants are used, but the disinfectant has poor solubility and is easy to react with nonionic surfactants to lose efficacy, so that the using effect of the disinfectant is poor.
Based on the technical scheme, the disinfectant suitable for the high-temperature and high-pressure spray disinfection pipeline is of great significance.
Disclosure of Invention
The present invention is directed to solving at least one of the problems of the prior art. Therefore, the invention provides a disinfectant which can be effectively applied to high-temperature and high-pressure spray disinfection technology.
The invention also provides a disinfection composition containing the disinfectant.
According to an embodiment of the first aspect of the invention, the disinfectant is dimethylol hydantoin.
According to some embodiments of the present invention, the high temperature and high pressure spray disinfection pipeline is a disinfection pipeline installed in a molecular suspension disinfection machine of triband zero technology ltd, phantom in south of Hunan province or other disinfection machines based on the same principle (such as other disinfection devices based on the same principle of CN 109821049A).
According to some embodiments of the invention, the elevated temperature is 150 ℃ or higher; preferably 150 to 300 ℃.
According to some embodiments of the invention, the pipe diameter of the pipe is below 3 mm.
The disinfectant according to the embodiment of the invention has at least the following beneficial effects: the disinfectant can be well dispersed in a high-temperature high-pressure spray disinfection pipeline, smoke-shaped particles with moderate particle size (0.2-10 microns) can be well formed in the disinfectant at high temperature, and are sprayed out of the high-temperature high-pressure spray disinfection pipeline, so that pipeline blockage is not easy to occur.
The sanitizing composition according to the second aspect embodiment of the invention further comprises a builder.
According to some embodiments of the invention, the synergist is selected from polyols.
According to some embodiments of the present invention, the synergist is selected from lower polyols, wherein the lower polyol refers to a polyol having 4 or less carbon atoms.
According to some embodiments of the invention, the synergist is selected from glycols.
According to some embodiments of the invention, the synergist is at least one of propylene glycol, ethylene glycol, diethylene glycol, or triethylene glycol.
According to some embodiments of the invention, the disinfectant is present in the composition in an amount of 25% by weight or more. When the mass fraction of the disinfectant is more than 25%, the disinfectant composition can better kill gram-positive bacteria (staphylococcus aureus) and bacillus (such as bacillus subtilis).
According to some embodiments of the invention, the disinfectant is present in the composition in an amount of 45 to 55% by weight.
The disinfecting composition according to the embodiment of the invention has at least the following beneficial effects: the disinfectant of the scheme of the invention can form molecular nano spray by compounding with the synergist, increase the smoke yield and indicate the dissolution condition of the disinfectant; the synergist can assist in suspension, and the disinfection composition of the scheme of the invention can be more uniformly diffused to any corner in a disinfection space and can be durably suspended in the air for disinfection for hours; meanwhile, the composition can kill various viruses and pathogenic microorganisms (such as escherichia coli, bacillus subtilis, staphylococcus aureus and the like); is particularly suitable for killing microorganisms in livestock breeding places, and has good application prospect in the fields of veterinary drugs and defensive drugs.
Additional aspects and advantages of the invention will be set forth in part in the description which follows and, in part, will be obvious from the description, or may be learned by practice of the invention.
Drawings
Fig. 1 is a top view of a cultivation room during a disinfection effect test according to an embodiment of the present invention, in which 1 represents a disinfection machine placement position, 2 represents a vertical height plate placement position, and 3 represents another position for ground plate placement.
Fig. 2 is a layout of the vertical height plate of fig. 1.
FIG. 3 is a graph showing the colony distribution pattern in the plate before and after sterilization with the sterilizing composition of example 1 of the present invention.
FIG. 4 is a graph showing the colony distribution in the plate before and after sterilization with the sterilizing composition of example 2 of the present invention.
FIG. 5 is a graph showing the distribution of E.coli colonies on plates before and after 30min of sterilization with the sterilizing composition of example 3 of the present invention.
FIG. 6 is a graph showing the colony distribution in the plate after 40min of sterilization with the sterilizing composition of example 3 of the present invention.
FIG. 7 is a graph showing the distribution of Staphylococcus aureus colonies on plates before and after 30min of sterilization with the sterilizing composition of example 3 of the present invention.
FIG. 8 is a graph showing the distribution of Bacillus subtilis colonies on plates before and after 30min of sterilization with the sterilizing composition of example 3 of the present invention.
FIG. 9 is a graph showing the distribution of Bacillus subtilis colonies on plates before and after sterilization with the sterilizing composition of example 4 of the present invention.
FIG. 10 is a graph showing the distribution of Staphylococcus aureus colonies on plates before and after sterilization with the sterilizing composition of example 4 of the present invention.
FIG. 11 is a graph showing the distribution of E.coli colonies on plates before and after sterilization with the sterilizing composition of example 4 of the present invention.
FIG. 12 is a state view of a nozzle of a sterilizing machine using a sterilizing agent in example 5 of the present invention;
FIG. 13 is a view showing the state of a nozzle of a sterilizing machine using the disinfectant of comparative examples 1 to 3 of the present invention.
Detailed Description
In order to explain technical contents, achieved objects, and effects of the present invention in detail, the following description is made with reference to the accompanying drawings in combination with the embodiments. The test methods used in the examples are all conventional methods unless otherwise specified; the materials, reagents and the like used are commercially available reagents and materials unless otherwise specified.
The first embodiment of the invention is as follows: a disinfectant composition comprises dimethylol hydantoin powder and propylene glycol, wherein the mass fraction of dimethylol hydantoin is 55%.
The second embodiment of the invention is as follows: a disinfectant composition comprises dimethylol hydantoin powder and propylene glycol, wherein the mass fraction of dimethylol hydantoin is 45%.
The third embodiment of the invention is as follows: a disinfectant composition comprises dimethylol hydantoin powder and propylene glycol, wherein the mass fraction of dimethylol hydantoin is 35%.
The fourth embodiment of the invention is as follows: a disinfectant composition comprises dimethylol hydantoin powder and propylene glycol, wherein the mass fraction of dimethylol hydantoin is 25%.
The fifth embodiment of the invention is as follows: a disinfectant for high-temp and-pressure spray disinfecting pipeline is dihydroxymethyl hydantoin.
The first comparative example of the present invention is: a disinfection composition comprises dibromohydantoin powder and propylene glycol, wherein the mass fraction of the dibromohydantoin is 55%.
The second comparative example of the present invention is: a disinfectant composition comprises dichlorohydantoin powder and propylene glycol, wherein the mass fraction of the dichlorohydantoin is 55%.
The third comparative example of the present invention is: a disinfectant composition comprises bromochlorohydantoin powder and propylene glycol, wherein the mass fraction of the bromochlorohydantoin is 55%.
To test the performance of the disinfecting compositions of examples 1 to 4 and comparative examples 1 to 3, the following tests were carried out:
selecting 8 breeding rooms (numbered 1-8 in sequence) which are subjected to any disinfection in a certain farm within 1 month before the test (the space volume is 1000 m)3Height 4m) as shown in fig. 1, the sterilizer is placed at position 1 and position 2The plates are placed in the distribution shown in fig. 2, and position 3 places only one plate on the ground. A test flat plate is placed on the ground at the position No. 2, the wall at the positions 1m, 2m and 3m in each room. Before the test, the ground is flushed with tap water, and the test is carried out after the ground is naturally dried for 1 h. Each test plate (commercially available TSA solid medium) in each culture room was provided with three groups, and group I was coated with 10 layers before testing5cfu/ml representative gram-negative bacteria (E.coli, product number zk09800, Beijing Kezhu Biotech, Inc.), group II before testing 105cfu/ml gram-positive bacteria (Staphylococcus aureus) and group III 10 before testing5cfu/ml Bacillus (Bacillus subtilis, available from Beijing Kogyo Biotech Co., Ltd., product No. CMCC (B) 63501). Wherein, a phantom 360 molecular suspension sterilizer (placed at position No. 1 in figure 1) is placed in No. 1-7 breeding rooms, the sterilizing compositions of examples 1-4 and comparative examples 1-3 are sequentially matched for use, and the molecular suspension sterilizer and a test panel are placed in a distribution manner in figures 1 and 2. In fig. 2, 2.1a represents an upright flat plate placed at a height of 3 meters, and 2.1b represents an inverted flat plate placed at a height of 3 meters; 2.2a represents an upright flat plate placed at a height of 2m, and 2.2b represents an inverted flat plate placed at a height of 2 m; 2.3a represents an upright flat plate placed at a height of 1 meter, and 2.3b represents an inverted flat plate placed at a height of 1 meter; 2.4a represents a flat upright placed at the ground. Except that no phantom 360 molecule suspension disinfector is used in the No. 8 breeding room, the arrangement of the other parts is the same as that of the pictures 1 and 2, and the flat plate which is under the same condition with the rooms 1-7 is placed on the ground of the room 8 to be used as a contrast.
The specific operations in the test procedure were as follows: starting a sterilizer (the temperature is set to 150 ℃, the spraying is usually finished within 3-5 min, and the spraying is finished within 4min in the test process), and spraying according to the volume of 1ml/m3The disinfectant composition is sprayed upwards, the disinfectant composition is sprayed out of a pipeline of the sterilizer after being gasified, and high-pressure spraying is formed due to the small diameter of the pipeline, so that smoke-shaped particles are formed at the outlet of the pipeline. After a certain period of action (40 min for example 1, 50min for example 2, and 30min for others), the plates were harvested and placed in a 37 ℃ incubatorAfter 12h incubation, the plate surface was examined for colony distribution.
The disinfection results of the disinfection composition of example 1 are shown in fig. 3, in which the disinfection composition of fig. 3 is placed on the floor 3 in room No. 8, room No. 1, 2.4a, 2.3b, 2.2a, 2.2b, 2.1a and 2.1b from left to right in the order of the plates, and staphylococcus aureus, escherichia coli and bacillus subtilis are placed on the plates from top to bottom in the order of the plates. As can be seen from FIG. 3, the disinfectant composition can almost completely kill the three microorganisms in the space, and the microorganisms in all places except the ground Escherichia coli, but the ground Escherichia coli can also completely kill after the action time is prolonged.
The disinfection results of the disinfection composition of example 2 are shown in fig. 4, from left to right, the disinfection composition is placed in the room No. 8, 2.3a, 2.3b, 2.1a, 2.1b (since the effect of 2.2a and b is similar to that of 2.3a and b, which are not included in the text for avoiding redundancy) and the disinfection composition is placed in the ground position No. 3 in the room No. 2, from top to bottom, in the order of staphylococcus aureus, escherichia coli and bacillus subtilis. As can be seen from FIG. 4, the disinfectant composition can almost completely kill the three microorganisms in the space, except the part on the ground where the microorganisms are not killed, the microorganisms in other places are completely killed, and the Escherichia coli on the ground can also be completely killed after the action time is prolonged. The 45% concentration of 1ml/m3 acts for 40 minutes, and can kill the air-borne Escherichia coli completely. Repeated experiments show that all the medicaments can be killed within 60 min.
The results of the disinfection composition of example 3 after 30min and 40min of E.coli treatment are shown in FIGS. 5 and 6, respectively, where the first row of plates in FIGS. 5 and 6 are placed in the No. 8 room, 2.3a, 2.2a and 2.1a positions in the No. 3 room in sequence from left to right; the second row of flat plates is sequentially placed at 2.3b, 2.2b and 2.1b positions in the No. 3 room from left to right. As can be seen from figures 5-6, after 30min of action, the disinfection composition can kill all the rightly placed escherichia coli; the sterilization rate of the escherichia coli which is placed on the flat plate after 40min of action is 100%. The results of Staphylococcus aureus and Bacillus subtilis after 30min of action are shown in FIGS. 7 and 8, respectively. In fig. 7, the first row of flat plates is sequentially placed in the room No. 8, the room No. 3 and the 2.3a and the 2.1a positions from left to right; the second row of flat plates is sequentially placed at 2.3b, 2.1b and 2.4a positions in the No. 3 room from left to right. Since the effect of 2.2a and b is similar to that of 2.3a and b, in order to avoid redundancy, the attached text does not show that staphylococcus aureus which is positioned and inverted at each position can be killed by 100% after 30min from the graph in fig. 7. In fig. 8, the first row of flat plates is sequentially placed in the room No. 8, 2.3a, 2.2a and 2.1a in the room No. 3 from left to right; the second row of flat plates is sequentially placed at 2.3b, 2.2b and 2.1b positions in the No. 3 room from left to right. As can be seen from FIG. 8, after 30min of action, the air Bacillus subtilis can achieve complete killing (i.e. the sterilization rate is 100%).
The results of the three bacteria after the disinfection composition in example 4 is acted for 30min are shown in fig. 9-11, wherein the first row of the bacteria in fig. 9-11 is placed in the room No. 8, 2.4a, 2.3a, 2.2a and 2.1a from left to right in the room No. 4 in sequence; the second row of flat plates are sequentially placed at the positions of No. 3, 2.3b, 2.2b and 2.1b in the No. 4 room from left to right. As can be seen from figures 9-11, after 30min of action, the air bacillus subtilis is positively killed completely (the sterilization rate is 100%), the sterilization rate is 90% at 3m position and is 50% at 1m position; the staphylococcus aureus is killed completely when being placed rightly and almost completely when being placed reversely.
The disinfectant of embodiment 5 of the invention also has a good disinfection effect, and can be sprayed in the air through the disinfection pipeline to be disinfected, so that the disinfectant has a good disinfection effect. The nozzle orifice is in the same condition as that in fig. 12 (similar to that in the other embodiments), and as can be seen from the figure, the nozzle orifice is in good condition and is not blocked.
In the disinfection compositions of comparative examples 1 to 3, due to the formation of flocculent structural substances, the pipeline of the disinfection machine is seriously blocked after the test is started (as shown in fig. 13), so that the subsequent test cannot be carried out; thus, it is shown that not all hydantoin-based compounds are suitable for high temperature and high pressure spray disinfection of pipelines. The above description is only an embodiment of the present invention, and not intended to limit the scope of the present invention, and all equivalent changes made by using the contents of the present specification and the drawings, or applied directly or indirectly to the related technical fields, are included in the scope of the present invention.
Claims (10)
1. The disinfectant suitable for high-temperature and high-pressure spray disinfection pipelines is characterized in that: the disinfectant is dimethylol hydantoin.
2. The disinfectant suitable for high-temperature and high-pressure spray sterilization of pipelines according to claim 1, wherein: the high temperature is 150 ℃ or higher.
3. The disinfectant suitable for high-temperature and high-pressure spray sterilization of pipelines according to claim 2, wherein: the high temperature is 150-300 ℃.
4. The disinfectant suitable for high-temperature and high-pressure spray sterilization of pipelines according to claim 1, wherein: the pipe diameter of the pipeline is below 3 mm.
5. A disinfecting composition comprising a disinfecting agent as claimed in any one of claims 1 to 4, characterized in that: also comprises a synergist.
6. The sanitizing composition according to claim 5, wherein: the synergist is selected from polyalcohol substances.
7. The sanitizing composition according to claim 6 wherein: the synergist is selected from lower polyol, wherein the lower polyol is a polyol with the carbon number of less than 4.
8. The sanitizing composition according to claim 5, wherein: the synergist is selected from dihydric alcohol substances; preferably at least one of propylene glycol, ethylene glycol, diethylene glycol or triethylene glycol.
9. The sanitizing composition according to claim 5, wherein: in the composition, the mass fraction of the disinfectant is more than 25%.
10. The sanitizing composition according to claim 9 wherein: the mass fraction of the disinfectant is 45-55%.
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