KR20090010160A - Stable vitamin c compositions - Google Patents

Abstract

Disclosed is a composition comprising ascorbic acid or a derivative thereof, a silicone containing compound, and an essential oil, wherein at least 50% of the initial amount of the ascorbic acid in the composition remains stable when the composition is stored for at least 1 month at room temperature. The composition can be non-aqueous.

Description

Stable Vitamin C Composition {STABLE VITAMIN C COMPOSITIONS}

Reference-linked to related application

This application claims priority to US Provisional Application No. 60 / 775,734, filed February 21, 2006, the entire contents of which are incorporated by reference.

Background of the Invention

A. Field of Invention

The present invention generally relates to compositions and methods that can be used to stabilize vitamin C.

B. Skills in Related Fields

Vitamin C is an antioxidant that can be beneficial to the skin when applied topically. Topical use of vitamin C may supplement sunscreen protection and may provide additional anticarcinogenic protection (Pinnel, 2003; Humbert 2001). Topical application of vitamin C may provide additional protection against sun damage (Lin et al., 2003). Vitamin C has been shown to result in clinically visible and statistically significant improvements in wrinkle formation in humans (Fitzpatrick et al., 2002).

Topical vitamin C application may be beneficial to the appearance and health of the skin, but there is a problem that the use of vitamin C in the cosmetic composition is limited. In particular, vitamin C can be difficult to stabilize in topical compositions. For example, US Pat. No. 2,400,171 describes the conversion of ascorbic acid to its calcium or zinc salt to maintain a stable aqueous solution. US Pat. No. 6,146,664 describes a difficulty in preparing a stable vitamin C composition due to ascorbic acid being an α-ketolactone having a double bond between the second and third carbon atoms of its structure. This is combined with the fact that the hydroxyl groups at the second and third carbon atoms of vitamin C make vitamin C a fairly strong reducing agent. Thus, in aqueous media, vitamin C loses its beneficial effects due to degradation or reaction with other compounds.

Summary of the Invention

One aspect of the invention relates to compositions comprising ascorbic acid or derivatives thereof, silicone containing compounds, and / or essential oils. The composition may be nonaqueous. Ascorbic acid may be particulate ascorbic acid. Ascorbic acid may be suspended in the composition and / or substantially insoluble in the composition. Particulate ascorbic acid may comprise a particle size of less than about 50 μm. In other embodiments, the particulate size is 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 25, 30 , 35, 40, 45, 50, 60, 70, 80, 90, 100, 150, 200, 250, 300, 350, 400, 450, 500, 550, 600, 650, 700, 750, 800, 850, 900 , 950, 1000, 2000, 3000, 4000, 5000 μm or more, or any number derivable therefrom. In certain embodiments, the particulate ascorbic acid is an ultrafine powder (eg, vitamin C particles having a particle size of about 75 to 850 μm). In certain non-limiting embodiments, the composition can comprise about 5% to about 15%, or about 7% to about 10% by weight of ascorbic acid of the total composition. However, as mentioned elsewhere herein, the amount of vitamin C in the composition may extend beyond the aforementioned ranges. We also contemplate that the compositions of the invention may be aqueous compositions. In certain embodiments, the ratio of any component in the composition as compared to another component (eg, vitamin C to essential oil (s), vitamin C to silicone containing compounds, silicone containing compound to essential oils, vitamin C to phytantriol, and the like) ) Is about 1: 1, 2: 1, 3: 1, 4: 1, 5: 1, 6: 1, 7: 1, 8: 1, 9: 1, 10 based on the weight or volume of the total composition : 1, 11: 1, 12: 1, 13: 1, 14: 1, 15: 1, 16: 1, 17: 1, 18: 1, 19: 1, 20: 1, 21: 1, 22: 1 , 23: 1, 24: 1, 25: 1, 26: 1, 27: 1, 28: 1, 29: 1, 30: 1, 31: 1, 32: 1, 33: 1, 34: 1, 35 : 1, 36: 1, 37: 1, 38: 1, 39: 1, 40: 1, 50: 1, 60: 1, 70: 1, 80: 1, 90: 1, 100: 1 or more, Or any number derivable therefrom. In other embodiments, the ratio of any ingredient in the composition as compared to another ingredient (eg, vitamin C to essential oil (s), vitamin C to silicone containing compounds, silicone containing compound to essential oils, vitamin C to phytantriol, and the like) ) Is about 1: 2, 1: 3, 1: 4, 1: 5, 1: 6, 1: 7, 1: 8, 1: 9, 1:10, 1 based on the weight or volume of the total composition : 11, 1:12, 1:13, 1:14, 1:15, 1:16, 1:17, 1:18, 1:19, 1:20, 1:21, 1:22, 1:23 , 1:24, 1:25, 1:26, 1:27, 1:28, 1:29, 1:30, 1:31, 1:32, 1:33, 1:34, 1:35, 1 : 36, 1:37, 1:38, 1:39, 1:40, 1:50, 1:60, 1:70, 1:80, 1:90, 1: 100 or more, or derived from It can be any number possible.

In other non-limiting embodiments, the compositions of the present invention comprise less than about 50% by weight of the silicon containing compound (e.g., 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12 , 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37 , 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48 or 49%). Other ranges for the amount of silicone containing compound in the composition are contemplated and are provided in other sections herein. In certain embodiments, the silicon containing compound is cyclomethicone. However, it should be appreciated that other silicone containing compounds described in other sections of this specification and silicone containing compounds known to those skilled in the art are considered useful in the present invention. In certain embodiments, ascorbic acid is suspended in silicone containing compounds or essential oils or both.

Non-limiting examples of essential oils that can be used in the context of the present invention include the essential oils identified herein and those known to those skilled in the art. For example, essential oils include sesame oil, macadamia nut oil, tea tree oil, evening primrose oil, Spanish sage oil, Spanish rosemary oil, Coriander oil and Thyme oil. Or Pimento berry oil. In other embodiments, the essential oil is 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 30, 40 or 50 or more combinations of various essential oils. In certain embodiments, the compositions of the present invention include sesame oil; Macadamia nut oil; Tea tree oil; Evening primrose oil; Spanish sage oil; Spanish rosemary oil; Coriander oils; Combinations of both essential oils such as thyme oil or pimento berry oil. In certain embodiments, the compositions of the present invention do not comprise nonvolatile oils.

In another non-limiting embodiment, the compositions of the present invention can include thickening agents, including thickening or gelling agents. In certain embodiments, the thickener is trihydroxystearin or hydrogenated polyisobutene, or a combination of both. However, it should be appreciated that other thickeners described in other sections of this specification and thickeners known to those skilled in the art are contemplated as being useful in the present invention. In certain non-limiting embodiments, the compositions of the present invention comprise from about 5% to about 15%, or from about 7% to about 10% by weight of the thickening agent of the total composition. However, as mentioned elsewhere herein, the amount of thickening agent in the composition may extend beyond the aforementioned ranges.

In other embodiments of the invention, the composition is not an emulsion. In certain embodiments, the composition does not include an emulsifier or surfactant, or both. However, as described in other sections of this specification, the composition may be an emulsion and may include emulsifiers or surfactants or both. In a non-limiting embodiment, the composition can have a pH of about 6 to about 9. In other embodiments, the pH may be 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13 or 14.

The compositions of the present invention may also be stored stably (eg, the components may remain stable or active during and / or after storage). In certain embodiments, the composition is 1, 2, 3, 4, 5 or 6 days at room temperature, or 1, 2, 3 or 4 weeks, or 1, 2, 3, 4, 5, 6, 7, 8, 9, Stably stored if stored for 10, 11 or 12 months, or 1, 2, 3, 4, 5, 6, 7, 8, 9 or 10 years or more. In other non-limiting embodiments, the ascorbic acid in the composition is 1, 2, 3, 4, 5 or 6 days, or 1, 2, 3 or 4 weeks, or 1, 2, 3, 4, 5 at room temperature May remain stable or active if stored for 6, 7, 8, 9, 10, 11 or 12 months, or 1, 2, 3, 4, 5, 6, 7, 8, 9 or 10 years or more Can be. In another non-limiting embodiment, at least 1, 5, 10, 15, 20, 30, 40, 50, 60, 70, 80, 90, 95, 96, 97, 98, 99% or 100 of the initial amount of ascorbic acid %, The composition is 1, 2, 3, 4, 5 or 6 days at room temperature, or 1, 2, 3 or 4 weeks, or 1, 2, 3, 4, 5, 6, 7, 8, 9, 10 , 11 or 12 months, or 1, 2, 3, 4, 5, 6, 7, 8, 9, or 10 years or more, and then remain stable or active.

In other non-limiting embodiments, the compositions of the present invention can be formulated into cosmetic compositions. The composition may be formulated for topical application to the skin. The composition can be included in a cosmetic vehicle. Non-limiting examples of cosmetic vehicles are described in other sections of this specification and are known to those skilled in the art. Examples of cosmetic vehicles include emulsions (eg oil-in-water and water-in-oil emulsions), creams, lotions, solutions (eg aqueous or hydro-alcoholic solutions), anhydrous bases (eg lipsticks) Or powders), gels and ointments. In other non-limiting embodiments, the compositions of the present invention can be included in anti-aging products, cleansing products or moisturizing products. The composition may also be formulated to include a nonaqueous nonpolar organic solvent. In certain embodiments, the non-aqueous nonpolar organic solvent comprises cyclomethicone or trihydroxystearin or a combination of both. The composition may also be formulated for topical application to the skin 1, 2, 3, 4, 5, 6, 7 or more times per day during use. In other embodiments, the compositions of the present invention may be formulated into dietary compositions, pharmaceutical compositions, injectable compositions, and the like.

In certain embodiments, the compositions of the present invention comprise about 7% to about 10% by weight of ascorbic acid or derivatives thereof, about 20% to about 30% by weight of a silicon containing compound, and about 40% to about 50% by weight Essential oils or mixtures of essential oils. The composition may also include from about 7 wt% to about 10 wt% thickener.

In other embodiments, the composition may comprise vitamin E. Vitamin E may be tocopherol or tocopheryl acetate. The composition may comprise vitamin A. Vitamin A may be vitamin A palmitate, retinyl palmitate or retinoic acid. The composition may comprise beta carotene, phytantriol (CAS No. 74563-64-7) or triclicelide. Non-limiting triglycerides include the triglycerides described in other sections of this specification and triglycerides known to those skilled in the art. Examples of such triglycerides include small, medium and large chain triglycerides. In certain embodiments, the triglycerides are medium chain triglycerides (eg caprylic / capric triglycerides). The composition may also include a preservative. Non-limiting examples of preservatives include methylparabens, propylparabens, or mixtures of methylparabens and propylparabens.

In another aspect of the invention, the inventors contemplate methods of treating or preventing skin diseases, including topically applying the compositions of the invention to the skin. Non-limiting examples of skin diseases include pruritis, spider veins, melanoma, blotch, senile purpura, keratosis, blemishes, spots, fine lines or wrinkles, measures, sun damaged skin, dermatitis (e.g. Dermatitis, monetary dermatitis, contact dermatitis, atopic dermatitis, exfoliative dermatitis, perioral dermatitis, and congestive dermatitis), psoriasis, folliculitis, rosacea, acne, impetigo, sole, erythrasma, eczema and the like. In certain non-limiting embodiments, the skin disease is caused by exposure to UV light, age, radiation, chronic sun exposure, environmental pollutants, air pollution, wind, low temperature, heat, chemicals, disease pathology, smoking or malnutrition Can be. The skin can be facial skin or non-facial skin (eg, arms, legs, hands, chest, back, feet, etc.). The method may further comprise identifying a person in need of treating the skin. The person can be male or female. The age of a person is 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 15, 20, 25, 30, 35, 40, 45, 50, 55, 60, 65, 70, 75, It may be 80, 85, 90, 95 years of age or older, or any range derivable therefrom. The method also increases the rate of stratum corneum conversion of the skin; Increase collagen synthesis in fibroblasts; Skin cells (eg, keratinocytes, melanocytes, etc.) that increase the cell's antioxidant defense mechanisms (eg, exogenous addition of antioxidants reduce or prevent oxidative damage to skin, cells, proteins and lipids) Reinforce, supplement or prevent the loss of cellular antioxidants such as catalase or glutathione in Langerhans cells, etc.); Inhibit melanogenesis in melanocytes; Topically applying an amount effective to reduce or prevent oxidative damage to the skin (including reducing the amount of lipid peroxides and / or protein oxidation in the skin). In certain embodiments, the method comprises applying the composition to the skin one, two, three, four, five, six, seven or more times a day.

Another embodiment of the invention is directed to a method of making a vitamin C composition that is stably stored. Such methods may include obtaining ascorbic acid or a derivative thereof, obtaining a silicone containing compound, obtaining an essential oil, and mixing the ascorbic acid or a derivative thereof, a silicone containing compound and an essential oil to obtain a composition, wherein the composition Ascorbic acid (or ascorbic acid derivatives) in the stomach is stable or active. In certain embodiments, the composition is 1, 2, 3, 4, 5 or 6 days at room temperature, or 1, 2, 3 or 4 weeks, or 1, 2, 3, 4, 5, 6, 7, 8, 9, 1, 5, of the initial amount of ascorbic acid (or derivative thereof) when stored for 10, 11 or 12 months or 1, 2, 3, 4, 5, 6, 7, 8, 9 or 10 years or more At least 10, 15, 20, 30, 40, 50, 60, 70, 80, 90, 95, 96, 97, 98, 99% or 100% remains stable or active. In certain embodiments, the ascorbic acid is particulate ascorbic acid. Ascorbic acid may be insoluble in the composition. The composition may be nonaqueous. The composition may include other properties or ingredients identified herein, and properties or ingredients known to those skilled in the art.

We also contemplate kits comprising the compositions of the invention. In certain embodiments, the composition is included in a container. The container may be a bottle, dispenser or package. The container may dispense an amount of the composition. In certain embodiments, the composition is dispensed in a spray, lump or liquid. The container may include an indication on its surface. The indication may be a word, abbreviation, picture or symbol.

The inventors also contemplate articles comprising the compositions of the invention. In a non-limiting embodiment, the product can be a cosmetic product. The cosmetic product may be a product described in other sections of this specification or a product known to those skilled in the art. Non-limiting examples of products include moisturizers, creams, lotions, emollients, foundations, night creams, lipsticks, cleansers, toners, sunscreens, masks, or anti-aging products.

It is contemplated that any embodiment described herein may be performed by any method or composition of the present invention and vice versa. In addition, the composition of the present invention can be used to achieve the method of the present invention.

"Non-volatile oil" includes materials that do not evaporate at room temperature or room temperature.

The term "vitamin C" or "ascorbic acid" includes L-ascorbic acid and derivatives thereof.

The term "dissolved", "dissolved" or any variation of such terms means that ascorbic acid is partially or completely dissolved in the composition of the present invention.

The term "suspended", "suspended" or any variation of such terms means that ascorbic acid is partially or completely dispersed in the composition of the present invention.

"Room temperature" includes the ambient temperature of a given room (eg, laboratory, medicine box, bathroom, etc.), and in most cases includes a temperature of about 20 ° C to about 25 ° C.

The terms “mixture”, “mix” and “mixing” or any variation of such terms, as used in the claims and / or specification, include stirring, blending, dispersion, milling, homogenization, and other similar methods. . Mixing of the components or components of the described compositions can form a solution. In other embodiments, the mixture may not form a solution. The component / component may also be present as an insoluble colloidal suspension.

The term "about" or "approximately" is defined as being understood by one of ordinary skill in the art, and in one non-limiting embodiment such term is defined to be within 10%, within 5%, within 1% or within 0.5%.

The term "substantially" and variations thereof are defined primarily as being understood by those skilled in the art, but not necessarily necessarily, and in one non-limiting embodiment "substantially" is within 10%, within 5%, 1%. Within the range or within 0.5%.

The term “inhibiting”, “reducing” or “preventing” or any variation of such terms, when used in the claims and / or specification, refers to any measurable reduction or complete inhibition to achieve the desired result. Include.

The term "effective" when used in the specification and / or claims means sufficient to achieve the desired, expected or intended result.

The use of the word "a" or "an" may mean "one" when used with the term "comprising" in the claims and / or in the specification, but "one or more", "at least one" and "one" Or more than that ".

The use of the term “or” in the claims supports the definition of meaning only alternative and “and / or”, but unless expressly indicated to mean only alternative or alternatively mutually exclusive. , "And / or" is used to mean.

As used herein and in the claim (s), the terms “consisting” (and any form thereof, such as “consisting of” and “consisting of”), “having” (and any thereof) In the form of, for example, "bears" and "bears"), "comprising" (and any form thereof, such as "comprises" and "comprises") or "containing" (And any form thereof, such as "contains-" and "contains-") are integral or change from context to context and do not exclude additional non-mentioned components or method steps.

Other objects, features and advantages of the present invention will become apparent from the following detailed description. However, it should be understood that the detailed description and examples presented by specific embodiments of the present invention are provided by way of example only. It is also contemplated that changes and modifications within the spirit and scope of the invention will become apparent to those skilled in the art from this detailed description.

Description of Exemplary Embodiments

In today's image-aware society, people are constantly looking for products that can improve the visual appearance of their skin. Vitamin C has been shown to exert a number of beneficial effects on human skin. For example, due to its antioxidant properties, vitamin C has the ability to inhibit toxic free-radicals from skin damage. This may be important for smokers or people who are frequently near smokers or those who are exposed to excessive sunlight or air pollutants (ie, known causes of free-radical damage to the skin).

Vitamin C is also an essential nutrient for the production of skin collagen (a protein that provides elasticity to the skin). As a person ages, the collagen content of the skin decreases. In addition, exposure to the sun can promote age-related collagen loss from the skin. Vitamin C can help reduce or even restore the age-related decrease in collagen content of the skin.

In addition, vitamin C has been found to restore the vitamin E content of the skin. Similar to vitamin C, vitamin E has antioxidant properties that favor skin protection. Thus, vitamin C has the ability to restore the vitamin E content of the skin, which provides an additional level of protection against antioxidant damage to the skin.

In addition, people suffer from limited blood circulation to the skin as they age. Because of this, the skin may not be supplied with vitamin C obtained from a dietary or supplemental source. Therefore, topical application of vitamin C becomes more important as a person ages.

We have found a non-aqueous cosmetic composition with the ability to stabilize vitamin C for an extended period of time. In certain non-limiting embodiments, the composition comprises ascorbic acid or a derivative thereof; Silicon-containing compounds; And essential oils or mixtures of essential oils. These and other aspects of the invention are described in further detail in the following sections.

A. Vitamin C and Derivatives of Vitamin C

Vitamin C is a water soluble vitamin that can be derived from glucose via the euonic acid pathway. As an antioxidant, vitamin C can neutralize free radicals looking for electrons to restore stability. Vitamin C is a source of electrons for free-radicals. Because of this, vitamin C can prevent free radicals from drawing electrons from the source, which can cause significant damage to the skin (eg, skin cells, proteins, etc.).

The stable form of vitamin C is ascorbic acid. The compound name for vitamin C is 2-oxo-L-threo-hexono-1,4-lactone-2,3-ene-diol (also known as ascorbic acid or L-ascorbic acid). CAS numbers associated with ascorbic acid are CAS Nos. 50-81-7 (L-type) and 62624-30-0. The chemical structure of stable vitamin C is as follows:

Derivatives of vitamin C are also considered useful in the context of the present invention. In certain embodiments, “derivative” means a chemically modified compound that still retains the desired properties of the compound before modification of the compound (eg, vitamin C). Thus, vitamin C derivatives may be equivalent to vitamin C in that such derivatives may possess similar effects of vitamin C compounds. Non-limiting examples of such derivatives include ascorbic acid polypeptides, ascorbyl dipalmitate, ascorbyl methylsilanol pectinate, ascorbyl palmitate, ascorbyl stearate, sodium ascorbyl palmitate, disodium astaxanthin Corville sulfate, ester of ascorbic acid, magnesium ascorbate, magnesium ascorbyl phosphate, methylsilanol ascorbate, potassium ascorbyl tocopheryl phosphate, sodium ascorbate, ascorbyl glucoside, or ascorbic Bill Tocopheryl Maleate.

We also contemplate that the following modifications to the vitamin C structure can be made in the context of the present invention. Non-limiting examples of such modifications include lower alkanes such as methyl, ethyl, propyl, or substituted lower alkanes such as hydroxymethyl or aminomethyl groups; Carboxyl group and carbonyl group; Hydroxyl; Nitro, amino, amide, and azo groups; Addition or removal of sulfates, sulfonates, sulfonos, sulfhydryls, sulfonyls, sulfoxides, phosphates, phosphonos, phosphoryl groups, and halide substituents. Further modifications include the addition or deletion of one or more atoms of the atomic framework, eg the substitution of ethyl by propyl; Substitution of phenyl by larger or smaller aromatic groups. Alternatively, in cyclic or bicyclic structures, heteroatoms such as N, S or O may be substituted in the structure instead of carbon atoms.

B. Silicone-Containing Compounds

Silicone containing compounds may have beneficial effects when used in the context of the present invention. These compounds have, for example, the ability to substantially prevent the absorption of water or oxygen into the composition. Due to the ability of water or oxygen to destabilize vitamin C, excluding these elements may help maintain the stability of vitamin C.

In a non-limiting embodiment, the silicon containing compound includes any member of the polymerization product group consisting of alternating silicon and oxygen atoms, along with the side groups where the molecular backbone is attached to the silicon atom. By varying the -Si-O- chain lengths, side groups, and crosslinks, silicones can be synthesized into a wide variety of materials. These can be consistently changed from liquid to gel to gel.

Silicone-containing compounds that can be used in the context of the present invention include the silicone-containing compounds described herein or silicone-containing compounds known to those skilled in the art. Non-limiting examples include silicone oils (eg, volatile and nonvolatile oils), gels, and solids. In one embodiment, the silicon containing compound comprises a silicone oil, for example polyorganosiloxane. Non-limiting examples of polyorganosiloxanes include dimethicone, cyclomethicone, polysilicon-11, phenyl trimethicone, trimethylsilylamodimethicone, stearoxytrimethylsilane or mixtures thereof, and the intended application (eg And other organosiloxane materials in any provided ratio to achieve the desired consistency and application properties, depending on the particular area, such as application to the skin, hair or eye. "Volatile silicone oils" include silicone oils having low thermal evaporation, ie, generally less than about 50 cal thermal evaporation per gram of silicone oil. Non-limiting examples of volatile silicone oils include cyclomethicones such as Dow Corning 344 Fluid, Dow Corning 345 Fluid, Dow Corning 244 Fluid, and Dow Corning 245 Fluid, Volatile Silicone 7207 (Union Carbide Corp , Danbury, Conn.); Low viscosity dimethicones, ie dimethicones having a viscosity of about 50 cst or less (eg, dimethicones such as Dow Corning 200-0.5 cst fluid). Dow Corning Fluid is available from Dow Corning Corporation, Midland, Michigan. Cyclomethicone and dimethicone are each end-blocked in cyclic dimethyl polysiloxane compounds and trimethylsiloxy units in the Third Edition of the CTFA Cosmetic Ingredient Dictionary (incorporated herein by reference). It is described as a mixture of linearly methylated linear siloxane polymers. Other non-limiting volatile silicone oils that can be used in the context of the present invention include General Electric Co., Silicone Products Div., Waterford, NY, and SWS Silicones Div. Of Stauffer Chemical Co. , Adrian, Michigan).

C. Refinery

Essential oils include oils derived from grasses, flowers, trees and other plants. Such oils are typically present in small droplets between plant cells and are known to those skilled in the art in several ways (eg, steam distillation, chilling (ie, extraction with fat), maceration, solvent extraction, or mechanical Compression). When oils of this type are exposed to the atmosphere, they tend to evaporate (ie are volatile oils). As a result, many essential oils are colorless but can oxidize and turn dark over time. Essential oils are water insoluble and soluble in alcohols, ethers, nonvolatile oils (vegetables), and other organic solvents. Typical physical properties found in essential oils include various boiling points from about 160 ° C. to 240 ° C. and densities in the range from about 0.759 to about 1.096.

Essential oils are commonly named by the plants or vegetables on which these oils are found. For example, rose oil or peppermint oil is derived from rose or peppermint plants, respectively. Non-limiting examples of essential oils that may be used in the context of the present invention include sesame oil, macadamia nut oil, tea tree oil, evening primrose oil, Spanish sage oil, Spanish rosemary oil, coriander oil, thyme oil, pimento berry oil, rose oil, anise Oil, balsam oil, bergamot oil, rosewood oil, cedar oil, chamomile oil, sage oil, clary sage oil, cloves oil, cypress oil, eucalyptus oil, fennel oil, sea fennel oil, frankincense oil, geranium oil, ginger oil, Grapefruit oil, jasmine oil, juniper oil, lavender oil, lemon oil, lemongrass oil, lime oil, mandarin oil, marjoram oil, myrrh oil, neroli oil, orange oil, patchouli oil, pepper oil, pepper oil, petti Grain oil, pine oil, rose otto oil, rosemary oil, sandalwood oil, spearmint oil, sage o Sun, vetiver oil, winter green oil, or ylang-ylang oil. Other essential oils known to those skilled in the art are also considered useful in the context of the present invention (see, for example, the International Cosmetic Ingredient Dictionary, 10th edition, 2004).

D. Thickening Agent

Thickeners, including thickeners or gelling agents, include substances that can increase the viscosity of the composition. Thickeners include those that can increase the viscosity of a composition without substantially changing the efficacy of the components in the composition. Thickeners can also increase the stability of the compositions of the present invention. In certain embodiments of the invention, the thickener comprises hydrogenated polyisobutene or trihydroxystearin, or a mixture of both. Other examples include fumed silica and / or other silicone based thickeners.

Non-limiting examples of additional thickeners known to those skilled in the art can be used in the context of the present invention (e.g., US Patent Nos. 5,087,445; 4,509,949; 2,798,053; International Cosmetic Ingredient Dictionary, 10th edition, 2004). Examples include carboxylic acid polymers, crosslinked polyacrylate polymers, polyacrylamide polymers, polysaccharides, and gums. Examples of carboxylic acid polymers include crosslinked compounds containing acrylic acid, substituted acrylic acid, and one or more monomers derived from salts and esters of such acrylic acid and substituted acrylic acid, wherein the crosslinker is two or more carbon-carbon double It contains a bond and is derived from polyhydric alcohol. Examples of commercially available carboxylic acid polymers are carbomers (eg, Carbopol ™ from BF Goodrich, which is a homopolymer of acrylic acid crosslinked with allyl ethers of sucrose or pentaerythritol). 900 series).

Non-limiting examples of crosslinked polyacrylate polymers include cationic and nonionic polymers. Examples thereof include US Pat. No. 5,100,660; 4,849,484; No. 4,835,206; No. 4,628,078; And 4,599,379.

Non-limiting examples of polyacrylamide polymers (including nonionic polyacrylamide polymers including substituted branched or unbranched polymers) include polyacrylamide, isoparaffin and laureth-7, multi-block airbornes of acrylamide Coalesce, and acrylamide substituted with acrylic acid and substituted acrylic acid.

Non-limiting examples of polysaccharides include cellulose, carboxymethyl hydroxyethyl cellulose, cellulose acetate propionate carboxylate, hydroxyethyl cellulose, hydroxyethyl ethyl cellulose, hydroxypropyl cellulose, hydroxypropyl, methyl cellulose, methyl hydroxy Oxyethylcellulose, microcrystalline cellulose, sodium cellulose sulfate, and mixtures thereof. Another example is that the hydroxy group of the cellulose polymer is hydroxyalkylated (eg, hydroxy ethylated or hydroxypropylated) to form hydroxyalkylated cellulose, followed by C ₁₀ -C ₃₀ straight chain or branched through ether linkages. Alkyl substituted cellulose which is further modified with a chain alkyl group. Typically, such polymers are ethers of C ₁₀ -C ₃₀ straight or branched chain alcohols with hydroxyalkylcelluloses. Other useful polysaccharides include sclerroglucans that contain a straight chain of (1-3) linked glucose units with (1-6) linked glucose every three units.

Non-limiting examples of gums that can be used in the present invention include acacia, agar, algin, alginic acid, ammonium alginate, amylopectin, calcium alginate, calcium carrageenan, carnitine, carrageenan, dextrin, gelatin, gellan gum, guar gum, guar hydride Roxypropyltrimonium chloride, hectorite, hyaluronic acid, hydrated silica, hydroxypropyl chitosan, hydroxypropyl guar, karaya gum, kelp, locust bean gum, natto gum, potassium alginate, potassium carrageenan, propylene glycol alginate , Sclerotium gum, sodium carboxymethyl dextran, sodium carrageenan, tragacanth gum, xanthan gum, and mixtures thereof.

E. equivalent

Known and unknown equivalents of the components discussed throughout this specification can be used in the compositions and methods of the present invention. Equivalents can be used as substitutes for the ingredients. Equivalents can also be used to add to the methods and compositions of the present invention. Those skilled in the art will be able to recognize and identify known and unknown equivalents that are acceptable for the component without undue experimentation.

F. Compositions of the Invention

Those skilled in the art will appreciate that compositions of the present invention may include components (eg, vitamin C, derivatives of vitamin C, silicone containing compounds, essential oils, thickeners, sunscreens, humectants, antioxidants, UVA and / or UVB protection) as discussed herein. It will be appreciated that it can include any number of combinations of sunscreens, emollients, emollients, vitamins, trace metals, antibacterial agents, plant extracts, fragrances, dyes and color components, structuring agents, emulsifiers, and the like. will be. It is also contemplated that the concentration of the components may vary. For example, in a non-limiting embodiment, the composition is about 0.0001%, 0.0002%, 0.0003%, 0.0004%, 0.0005%, 0.0006%, 0.0007%, 0.0008%, 0.0009%, 0.0010%, 0.0011% in its final form. , 0.0012%, 0.0013%, 0.0014%, 0.0015%, 0.0016%, 0.0017%, 0.0018%, 0.0019%, 0.0020%, 0.0021%, 0.0022%, 0.0023%, 0.0024%, 0.0025%, 0.0026%, 0.0027%, 0.0028 %, 0.0029%, 0.0030%, 0.0031%, 0.0032%, 0.0033%, 0.0034%, 0.0035%, 0.0036%, 0.0037%, 0.0038%, 0.0039%, 0.0040%, 0.0041%, 0.0042%, 0.0043%, 0.0044%, 0.0045%, 0.0046%, 0.0047%, 0.0048%, 0.0049%, 0.0050%, 0.0051%, 0.0052%, 0.0053%, 0.0054%, 0.0055%, 0.0056%, 0.0057%, 0.0058%, 0.0059%, 0.0060%, 0.0061% , 0.0062%, 0.0063%, 0.0064%, 0.0065%, 0.0066%, 0.0067%, 0.0068%, 0.0069%, 0.0070%, 0.0071%, 0.0072%, 0.0073%, 0.0074%, 0.0075%, 0.0076%, 0.0077%, 0.0078 %, 0.0079%, 0.0080%, 0.0081%, 0.0082%, 0.0083%, 0.0084%, 0.0085%, 0.0086%, 0.0087%, 0.0088%, 0.0089%, 0.0090%, 0.0091%, 0.0092%, 0.0093%, 0.0094%, 0.0095%, 0.0096%, 0.0097%, 0.0098%, 0.0099%, 0.0100%, 0.0200%, 0.0250%, 0.0275%, 0.0300%, 0.0325%, 0.0350%, 0.0375%, 0.0400%, 0.0425%, 0.0450%, 0.0475%, 0.0500%, 0.0525%, 0.0550%, 0.0575%, 0.0600%, 0.0625%, 0.0650% , 0.0675%, 0.0700%, 0.0725%, 0.0750%, 0.0775%, 0.0800%, 0.0825%, 0.0850%, 0.0875%, 0.0900%, 0.0925%, 0.0950%, 0.0975%, 0.1000%, 0.1250%, 0.1500%, 0.1750 %, 0.2000%, 0.2250%, 0.2500%, 0.2750%, 0.3000%, 0.3250%, 0.3500%, 0.3750%, 0.4000%, 0.4250%, 0.4500%, 0.4750%, 0.5000%, 0.5250%, 0.0550%, 0.5750%, 0.6000%, 0.6250%, 0.6500%, 0.6750%, 0.7000%, 0.7250%, 0.7500%, 0.7750%, 0.8000%, 0.8250%, 0.8500%, 0.8750%, 0.9000%, 0.9250%, 0.9500%, 0.9750%, 1.0% , 1.1%, 1.2%, 1.3%, 1.4%, 1.5%, 1.6%, 1.7%, 1.8%, 1.9%, 2.0%, 2.1%, 2.2%, 2.3%, 2.4%, 2.5%, 2.6%, 2.7 %, 2.8%, 2.9%, 3.0%, 3.1%, 3.2%, 3.3%, 3.4%, 3.5%, 3.6%, 3.7%, 3.8%, 3.9%, 4.0%, 4.1%, 4.2%, 4.3%, 4.4%, 4.5%, 4.6%, 4.7%, 4.8%, 4.9%, 5.0%, 5.1%, 5.2%, 5.3%, 5.4%, 5.5%, 5.6%, 5.7%, 5.8%, 5.9%, 6.0% , 6.1%, 6.2%, 6.3%, 6.4%, 6.5%, 6.6%, 6.7%, 6.8%, 6.9%, 7.0%, 7.1%, 7.2%, 7.3%, 7.4%, 7.5%, 7.6%, 7.7 % , 7.8%, 7.9%, 8.0%, 8.1%, 8.2%, 8.3%, 8.4%, 8.5%, 8.6%, 8.7%, 8.8%, 8.9%, 9.0%, 9.1%, 9.2%, 9.3%, 9.4 %, 9.5%, 9.6%, 9.7%, 9.8%, 9.9%, 10%, 11%, 12%, 13%, 14%, 15%, 16%, 17%, 18%, 19%, 20%, 21%, 22%, 23%, 24%, 25%, 26%, 27%, 28%, 29%, 30%, 35%, 40%, 45%, 50%, 60%, 65%, 70% , 75%, 80%, 85%, 90%, 95% or 99% or more, or in any range or integer derivable therefrom, and may include one or more components mentioned throughout the specification and claims have. In a non-limiting embodiment, the percentage can be calculated based on the weight or volume of the total composition. Those skilled in the art will appreciate that the concentration may vary depending on the desired effect of the composition and / or the product incorporated into the composition.

G. Vehicle

All types of vehicles can be incorporated into the compositions of the present invention. Non-limiting examples of suitable vehicles include emulsions (eg, water-in-oil, oil-in-water, oil-in-water, oil-in-water, oil-in-silicone emulsions), creams, lotions, solutions (both aqueous and hydro-alcohol), Anhydrous bases (eg, lipsticks and powders), gels, and ointments or any combination of the above known to those skilled in the art (Remington's, 1990). Variants and other suitable vehicles will be apparent to those skilled in the art and are suitable for use in the present invention. In certain embodiments, it is important that the concentrations and combinations of compounds, components and agents are selected so that the combination is chemically compatible and no complexes precipitate from the finished product.

H. Beauty Products

The compositions of the present invention may also be used in sunscreen products, sunless skin tanning products, hair products, nail products, moisturizing creams, creams and lotions, emollients, day lotions, gels, ointments, foundations that are beneficial to the skin. It can be used in many beauty products, including but not limited to, night creams, lipsticks, cleansers, toners, masks, or other known beauty products or applicators. In addition, the cosmetic product may be formulated as a leave-on or rinse-off product. In certain embodiments, the compositions of the present invention are independent products.

I. Additional Compounds, Agents and Ingredients That Can Be Used With the Compositions of the Invention

The compositions of the present invention are useful for other advantageous agents and compounds, such as sunscreens, acute or chronic moisturizers (eg, wetting agents, occlusive agents, and agents that affect the natural moisturizing mechanism of the skin), antioxidants, UVAs and / or Or sunscreens, emollients, emollients, vitamins, trace metals, antibacterial agents, plant extracts, fragrances, dyes and color components, structuring agents, and / or emulsifiers with UVB protection (US Pat. No. 6,290,938). Reference).

1. Sunscreen

Sunscreen agents that may be used with the compositions of the present invention include chemical and physical sunscreen agents. Non-limiting examples of chemical sunscreens that can be used include para-aminobenzoic acid (PABA), PABA esters (glyceryl PABA, amyldimethyl PABA and octyldimethyl PABA), butyl PABA, ethyl PABA, ethyl dihydroxypropyl PABA, benzo Phenones (oxybenzone, sulfisobenzone, benzophenone, and benzophenone-1 to 12), cinnamates (and octyl methoxycinnamate, isoamyl p-methoxycinnamate, octylmethoxy cinnamate, synoxate, di Isopropyl methyl cinnamate, DEA-methoxy cinnamate, ethyl diisopropyl cinnamate, glyceryl octanoate dimethoxy cinnamate and ethyl methoxy cinnamate), cinnamate ester, salicylate (homomethyl salicylate , Benzyl salicylate, glycol salicylate, isopropylbenzyl salicylate), anthranilate, ethyl urocanate, homosalate, and Parsol 1789 . Non-limiting examples of physical sunscreens include kaolin, talc and metal oxides (eg titanium dioxide and zinc oxide). Non-limiting examples of additional sunscreen agents known to those skilled in the art can be used in the context of the present invention (see, eg, the International Cosmetic Ingredient Dictionary, 10th edition, 2004, incorporated herein by reference).

2. Moisturizer

Non-limiting examples of moisturizers that can be used with the compositions of the present invention include amino acids, chondroitin sulfate, diglycerin, erythritol, fructose, glucose, glycerin, glycerol polymers, glycols, 1,2,6-hexanetriol, Beeswax, hyaluronic acid, hydrogenated beeswax, hydrogenated starch hydrolyzate, inositol, lactitol, maltitol, maltose, mannitol, natural moisturizing factor, PEG-15 butanediol, polyglyceryl sorbitol, salts of pyrrolidone carboxylic acid, potassium PCA, propylene glycol, sodium glucuronate, sodium PCA, sorbitol, sucrose, trehalose, urea, and xylitol.

Other examples include acetylated lanolin, acetylated lanolin alcohols, acrylates / C10-30 alkyl acrylate crosspolymers, acrylate copolymers, alanine, algae extracts, aloe barbadensis, aloe-barbadensis extracts. , Aloe barbadensis gel, althea officinalis extract, aluminum starch octenylsuccinate, aluminum stearate, apricot (prunus armeniaca) seed oil, arginine, arginine aspartate, Arnica montana extract, ascorbic acid, ascorbyl palmitate, aspartic acid, avocado (persea gratissima) oil, barium sulfate, barrier sphingolipids, butyl alcohol, beeswax, behenyl Alcohol, beta-sitosterol, BHT, birch (betula alba) bark extract, borage Borago officinalis extract, 2-bromo-2-nitropropane-1,3-diol, butcherbroom (ruscus aculeatus) extract, butylene glycol, calendula opi Calendula officinalis extract, calendula officinalis oil, candelilla (euphorbia cerifera) wax, canola oil, caprylic / capric triglycerides, cardamom ( Eletaria cardamomum oil, Carnauba (copernicia cerifera) wax, Carrageenan (chondrus crispus), Carrot (Daucus carota sativa) (daucus carota sativa)) oil, castor (ricinus communis) oil, ceramide, ceresin, ceteares-5, ceteares-12, ceteares-20, cetearyl octanoate, cethes- 20, cetes-24, cetyl acetate, cetyl octanoate , Cetyl palmitate, chamomile (anthemis nobilis) oil, cholesterol, cholesterol ester, cholesteryl hydroxystearate, citric acid, salvia (salvia sclarea) oil, cocoa (theob) Roman cacao butter, coco-caprylate / caprate, coconut (cocos nucifera) oil, collagen, collagen amino acids, corn (zea mays) oil, fatty acids, decyl Eight, dextrin, diazolidinyl urea, dimethicone copolyol, dimethiconol, dioctyl adipate, dioctyl succinate, dipentaerythryl hexacaprylate / hexacaprate, DMDM hydantoin, DNA, erythritol , Ethoxydiglycol, ethyl linoleate, eucalyptus globulus oil, evening primrose (oenothera biennis) oil, fatty acids, tructose, gel Latin, Geranium Makuratum Oil, Glucosamine, Glucose Glutamate, Glutamic Acid, Glyceres-26, Glycerin, Glycerol, Glyceryl Distearate, Glyceryl Hydroxtearate, Glyceryl Laurate, Glyceryl Linoleate, Glyceryl Myristate, glyceryl oleate, glyceryl stearate, glyceryl stearate SE, glycine, glycol stearate, glycol stearate SE, glycosaminoglycan, grape (vitis vinifera) seed oil, Hazelnut (Corylus americana) nut oil, hazelnut (Corylus avellana) nut oil, hexylene glycol, beeswax, hyaluronic acid, hybrid safflower (carthamus tinctorius) Oils, hydrogenated castor oil, hydrogenated coco-glycerides, hydrogenated coconut oil, hydrogenated lanolin, hydrogen Hydrogenated lecithin, hydrogenated palm glycerides, hydrogenated palm kernel oil, hydrogenated soymilk, hydrogenated resin glycerides, hydrogenated vegetable oils, hydrolyzed collagen, hydrolyzed elastin, hydrolyzed glycosaminoglycans, hydrolyzed Degraded keratin, hydrolyzed soy protein, hydroxylated lanolin, hydroxyproline, imidazolidinyl urea, iodopropynyl butylcarbamate, isocetyl stearate, isocetyl stearoyl stearate, isodecyl Oleate, isopropyl isostearate, isopropyl ranolate, isopropyl myristate, isopropyl palmitate, isopropyl stearate, isostearamide DEA, isostearic acid, isostearyl lactate, isostearyl neopentano Eight, Jasmine (jasminum officinale) oil, Jojoba (Northus Kinensis) buxus chinensis)) oil, kelp, cucui (aleurites moluccana) nut oil, lactamide MEA, lanes-16, lanes-10 acetate, lanolin, lanolin acid, lanolin alcohol, lanolin oil, Lanolin wax, lavender (lavandula angustifolia) oil, lecithin, lemon (citrus medica limonum) oil, linoleic acid, linolenic acid, macadamia ternifolia nut oil, magnesium stearate, magnesium Sulfate, maltitol, matricaria (chamomilla recutita) oil, methyl glucose sesquistearate, methylsilanol PCA, microcrystalline wax, mineral oil, mink oil, mortierella oil, myristyl lac Tate, myristyl myristate, myristyl propionate, neopentyl glycol dicaprylate / dicaprate, octyldodecanol, octyldodecyl myristate, octyl Dodecyl stearoyl stearate, octyl hydroxystearate, octyl palmitate, octyl salicylate, octyl stearate, oleic acid, olive (olea europaea) oil, orange (citrus aurantium) Dulcis (citrus aurantium dulcis) oil, palm (elaeis guineensis) oil, palmitic acid, panthetin, panthenol, panthenyl ethyl ether, paraffin, PCA, peach (prunus persica )) Nuclear oil, peanut (arachis hypogaea) oil, PEG-8 C12-18 ester, PEG-15 cocamine, PEG-150 distearate, PEG-60 glyceryl isostearate, PEG-5 glyceryl stearate, PEG-30 glyceryl stearate, PEG-7 hydrogenated castor oil, PEG-40 hydrogenated castor oil, PEG-60 hydrogenated castor oil, PEG-20 methyl glucose sesquistearate, PEG40 sorbitan ferrolate, PEG- 5 Soy Sterols, PEG-1O Soy Sterols, PEG-2 Stearate, PEG-8 Stearate, PEG-20 Stearate, PEG-32 Stearate, PEG-40 Stearate, PEG-50 Stearate, PEG-100 Stearate Latex, PEG-150 stearate, pentadecalactone, peppermint (mentha piperita) oil, petrolatum, phospholipids, polyamino sugar condensates, polyglyceryl-3 diisostearate, polyquaternium-24, Polysorbate 20, Polysorbate 40, Polysorbate 60, Polysorbate 80, Polysorbate 85, Potassium Myristate, Potassium Palmitate, Potassium Sorbate, Potassium Stearate, Propylene Glycol, Propylene Glycol Dicaprylate / Dicaprate, Propylene Glycol Dioctanoate, Propylene Glycol Dipellonate, Propylene Glycol Laurate, Propylene Glycol Stearate, Propylene Glycol Stearate SE, P VP, pyridoxine dipalmitate, quaternium-15, quaternium-18 hectorite, quaternium-22, retinol, retinyl palmitate, rice (Oriza sativa) bran oil, RNA, rosemary (rose) Marinus officinalis oil, rose oil, safflower (carthamus tinctorius) oil, sage (salvia officinalis) oil, salicylic acid, sandalwood (acid) Talum alboom oil, serine, serum protein, sesame (sesamum indicum) oil, shea butter (butyrospermum parkii), silk powder, sodium chondroitin sulfate, sodium Hyaluronate, sodium lactate, sodium palmitate, sodium PCA, sodium polyglutamate, sodium stearate, soluble collagen, sorbic acid, sorbitan laurate, sorbitan oleate, sorbitan palmitate, sorbitan Tan sesquioleate, sorbitan stearate, sorbitol, soybean (glycine soja) oil, sphingolipids, squalane, squalene, stearamide MEA-stearate, stearic acid, stearoxy dimethicone, stearoxytrimethyl Silane, stearyl alcohol, stearyl glycyrrhetinate, stearyl heptanoate, stearyl stearate, sunflower (helianthus annuus) seed oil, sweet almond (prunus amigdalus dulcis) prunus amygdalus dulcis)) oil, synthetic beeswax, tocopherol, tocopherol acetate, tocopheryl linoleate, tribehenin, tridecyl neopentanoate, tridecyl stearate, triethanolamine, tristearin, urea, vegetable oil, water , Wax, wheat (triticum vulgare) seed oil, and ylang-ylang (cananga odorata) oil. Non-limiting examples of additional moisturizers known to those skilled in the art can be used in the context of the present invention (see, for example, the International Cosmetic Ingredient Dictionary, 10th edition, 2004, incorporated herein by reference).

3. Antioxidants

Non-limiting examples of antioxidants that may be used with the compositions of the present invention include acetyl cysteine, ascorbic acid polypeptide, ascorbyl dipalmitate, ascorbyl methylsilanol pectinate, ascorbyl palmitate, ascorbyl stearate , BHA, BHT, t-butyl hydroquinone, cysteine, cysteine HCl, diamylhydroquinone, di-t-butylhydroquinone, disetyl thiodipropionate, dioleyl tocopheryl methylsilanol, disodium ascorbyl sulfate, Distearyl thiodipropionate, ditridecyl thiodipropionate, dodecyl gallate, erythorbic acid, ester of ascorbic acid, ethyl ferulate, ferulic acid, gallic acid ester, hydroquinone, isooctyl thioglycolate, Kojic acid, magnesium ascorbate, magnesium ascorbyl phosphate, methylsilanol ascorbate, natural plant antioxidant Agents, for example green tea or grape seed extract, nordihydroguaiaretic acid, octyl gallate, phenylthioglycolic acid, potassium ascorbyl tocopheryl phosphate, potassium sulfite, propyl gallate, quinone, rosmarinic acid, sodium astaxanthin Corbate, sodium bisulfite, sodium erythorbate, sodium metabisulfite, sodium sulfite, peroxide dismutase, sodium thioglycolate, sorbitol furfural, thiodiglycol, thiodiglycolamide, thiodiglycolic acid, Thioglycolic acid, thioractic acid, thiosalicylic acid, tocopheres-5, tocopheres-10, tocopheres-12, tocopheres-18, tocopheres-50, tocopherols, tocophersollan, tocopheryl acetate, tocopheryl linoleate , Tocopheryl nicotinate, tocopheryl succinate, and tris (nonylphenyl) phosphite. Non-limiting examples of additional antioxidants known to those skilled in the art can be used in the context of the present invention (see, for example, the International Cosmetic Ingredient Dictionary, 10th edition, 2004, incorporated herein by reference).

4. Structural Agent

In other non-limiting embodiments, the compositions of the present invention may comprise a structure former. In certain embodiments, the structurant helps to provide rheological properties to the composition and contributes to the stability of the composition. In other embodiments, the structurant may also act as an emulsifier or surfactant. Non-limiting examples of structurants include stearic acid, palmitic acid, stearyl alcohol, cetyl alcohol, behenyl alcohol, stearic acid, palmitic acid, stearyl alcohol with an average of about 1 to about 21 ethylene oxide units. Polyethylene glycol ethers, polyethylene glycol ethers of cetyl alcohol with an average of about 1 to about 5 ethylene oxide units, and mixtures thereof.

5. Emulsifier

In certain embodiments of the invention, the composition does not comprise an emulsifier. However, in other embodiments, the composition may comprise one or more emulsifiers. Emulsifiers can reduce the interfacial tension between phases and can improve the formulation and stability of the emulsion. Emulsifiers may be nonionic, cationic, anionic, and zwitterionic emulsifiers (see McCutcheon's (1986); U.S. Patent Nos. 5,011,681; 4,421,769; 3,755,560). Non-limiting examples include esters of glycerine, esters of propylene glycol, fatty acid esters of polyethylene glycol, fatty acid esters of polypropylene glycol, esters of sorbitol, esters of sorbitan anhydride, carboxylic acid copolymers, esters and ethers of glucose, ethoxy Silylated ethers, ethoxylated alcohols, alkyl phosphates, polyoxyethylene fatty ether phosphates, fatty acid amides, acyl lactylates, soaps, TEA stearates, DEA oleth-3 phosphates, polyethylene glycol 20 sorbitan monolaurate (polysorb Bait 20), polyethylene glycol 5 soy sterols, steares-2, steares-20, steares-21, ceteares-20, PPG-2 methyl glucose ether distearate, cetes-10, polysorbate 80, Cetyl phosphate, potassium cetyl phosphate, diethanolamine cetyl phosphate Sites, polysorbate 60, glyceryl stearate, and includes PEG-100 stearate, and mixtures thereof. Non-limiting examples of additional emulsifiers known to those skilled in the art can be used in the context of the present invention (see, for example, the International Cosmetic Ingredient Dictionary, 10th edition, 2004, incorporated herein by reference).

6. Additional Compounds and Agents

Non-limiting examples of additional compounds and agents that can be used with the compositions of the present invention include vitamins (eg, D, E, A, and K), trace metals (eg, zinc, calcium, and selenium), stimulants ( For example, steroid and nonsteroidal anti-inflammatory agents, plant extracts (for example, aloe vera, chamomile, cucumber extract, ginkgo, ginseng and rosemary), dyes and color components (for example, D & C Blue number 4, D & C green number 5, D & C orange number 5, D & C red number 17, D & C red number 33, D & C violet number 2, D & C yellow number 10, D & C yellow number 11 and DEA-cetyl phosphate), emollients (i.e. Organic esters, fatty acids, lanolin and derivatives thereof, vegetable and animal oils and fats, and diglycerides and triglycerides), antibacterial agents (eg triclosan and ethanol), and fragrances (natural and artificial fragrances).

J. Kit

It is also contemplated that kits may be used in certain embodiments of the present invention. For example, the compositions of the present invention can be included in a kit. The kit may comprise a container. The container may comprise a bottle, a metal tube, a thin tube, a plastic tube, a dispenser, a pressurized container, a barrier container, a package, a compartment, a lipstick container, a dense container, a cosmetic composition (eg, a foundation) Pans, or other types of containers such as dispersions or compositions or injection molded or blow molded plastic containers holding the desired bottles, dispensers or packages. The kit and / or container may comprise an indication on its surface. For example, the indication may be a word, phrase, abbreviation, picture or symbol.

The container may dispense an amount of the composition. In other embodiments, the container may be compressed (eg, a metal, sheet, or plastic tube) to dispense the desired amount of composition. The composition may be dispensed as a spray, aerosol, liquid, fluid, or semisolid. The container may have a spray, pump, or compression mechanism. The kit may also include instructions for use of the kit components with the use of any other dispersions or compositions contained in the container. Instructions can include a description of how to apply, how to use and maintain the product, dispersion or composition.

Example

The following examples are included to demonstrate certain non-limiting aspects of the invention. Those skilled in the art should recognize that the techniques described in the Examples are described as representative techniques discovered by the inventors in order to facilitate their function in the practice of the invention. However, one of ordinary skill in the art appreciates that modifications may be made in the specific embodiments described without departing from the spirit and scope of the invention, and that the same or similar results may be obtained.

Example 1

One embodiment of a non-limiting example of the invention is shown in Table 1. The ingredients in Table 1 provide stabilized vitamin C compositions.

Table 1

ingredient Concentration% (wt%) One. Vitamin C ^* 9.13 2. Sesame oil 46.739 ^** 3. Cyclomethicone 26.99 4. Trihydroxystearin 5.73 5. Hydrogenated polyisobutene 5.454 6. Caprylic / Capric Triglycerides 3.6 7. Macadamia Nut Oil 0.5454 8. Phytantriol 0.054 9. Tea tree oil 0.054 10. Tocopherol 0.2727 11. Evening Primrose Oil 0.054 12. Spanish sage oil 0.054 13. Spanish Rosemary Oil 0.054 14. Coriander oil 0.054 15. Thyme oil 0.054 16. Pimento Berry Oil 0.054 17. Vitamin A Palmitate 0.54 18. Methylparaben 0.54 19. Propylparaben 0.027 20. Beta carotene 0.00054 sum 100

^* This is a Non-limiting examples of vitamin C Vitamin C is an ultrafine powder. Ingredients 2-20 are added to the kitchenette planetary mixing apparatus at once in successive order. Add each ingredient while mixing continuously. Thereafter, vitamin C is added at short intervals and mixed continuously. All mixing procedures are carried out at room temperature.

^** Sesame oil rounded up to 46.739.

Example 2

Vitamin C Stability Study

The compositions described in Table 1 were stored at room temperature (about, 70-75 ° F.) for about 10 years. The composition was then tested to determine the amount of stable vitamin C remaining in the composition. The test procedure involved dispersing the composition in methyl alcohol. Vitamin C was then extracted from the sample using purified water. The stability of vitamin C was calculated by external standard method using reversed phase HPLC using variable wavelength detector (detailed description of the test method used is provided in Example 3). The results are shown in Table 2.

TABLE 2

Years % Of stable vitamin C in the composition 0 9.13 10 8.91

After about 10 years of room temperature storage, 97.6% of stable vitamin C was maintained in the composition. In addition, there was no significant discoloration in the old compositions.

Example 3

Vitamin C Stability Test

Non-limiting methods used to test vitamin C stability in the compositions of Table 1 are described in the following paragraphs.

Apparatus used : HPLC with variable wavelength UV detector and integrator (recommended settings include UV of 255 nm, flow rate of 0.75 mL / min, sample size 5 μL, temperature of 35 ° C.); NH ₂ column, 5μ, 25 cm × 4.6 mm (Whatman, Inc. catalog # 4691-3371); Assay balance (read at 0.1 mg); Volumetric flask (100 mL); Filter discs (nylon 0.45μ); Vortex; Ultrasonic crusher.

Reagents used : Ascorbyl Palmitate; Ascorbic acid; Methanol; Potassium phosphate (first); Phosphoric acid.

Calibration standard used : Approximately 20 mg (0.02 g) of each ascorbyl palmitate and ascorbic acid are added by weighing into a 100 mL volumetric flask. A sufficient amount of methanol is added to disperse the reagents and sonicate for about 10 minutes. Fill with methanol to 100 mL mark and mix. New calibration standards are made.

Mobile phase used : 70:30 methanol / 0.02 M potassium phosphate solution. 2.70 g of potassium monophosphate are dissolved in 1 liter of purified water and the pH is adjusted to 3.5 with phosphoric acid. Filter and mix 30 parts of this solution with 70 parts methanol.

Sample preparation used : The appropriate sample weight is calculated by the formula:

Samples are weighed and added to a 100 mL volumetric flask and the exact weight recorded as 0.1 mg. A sufficient amount of methanol is added to disperse the sample and sonicate for about 2 to 10 minutes. Fill with methanol to 100 mL mark and mix. The solution is filtered through a sample vial using a 0.45 μ filter disk. Samples are prepared in duplicate.

Calibration of HPLC : Calibrate the instrument using standard solutions. Inject three or more times to obtain reaction factors. The relative standard deviation of the response factors should not exceed 3.0%. The tailing factor should be less than 1.5.

Test procedure used : Inject the sample solution in duplicate and calculate the average of the results. The absolute residence time of the analyte peak in the calibration run is compared for each peak in the sample run. If the residence time differs by more than 5% relative, the calibration and sample run are repeated. The relative residence time between calibration and sample run is calculated as follows:

Where

RTs is the retention time of the I.Std or analyte peak in the sample run,

RTc is the retention time of the I.Std or analyte peak in the calibration run,

100 is 100 percent.

Wash the system with 30:70 methanol: water for about 30 minutes after the analysis is complete.

All compositions and / or methods described herein can be prepared and carried out without undue experimentation in light of the present disclosure. Although the compositions and methods of the present invention have been described in particular embodiments, modifications may be made to the steps and / or subsequent steps of the compositions and / or methods and methods described herein without departing from the spirit, spirit and scope of the invention. It will be apparent to those skilled in the art. More particularly, it will be apparent that certain agents which are chemically and physiologically related may replace the agents described herein and the same or similar results may be achieved. All such similar substitutions and variations apparent to those skilled in the art are deemed to be within the spirit, scope and concept of the invention as defined in the appended claims.

references

The following references, exemplary procedures they provide, or other details complementary to those described therein, are specifically incorporated herein by reference.

U.S. Patent 2,400,171

U.S. Patent No. 2,798,053

U.S. Patent 3,755,560

U.S. Patent 4,421,769

U.S. Patent 4,599,379

U.S. Patent 4,628,079

U.S. Patent 4,835,206

U.S. Patent 4,849,484

U.S. Patent 4,509,949

U.S. Patent 5,100,660

U.S. Patent 5,011,681

U.S. Patent 5,087,445

U.S. Patent 6,146,664

U.S. Patent 6,290,938

Claims (45)

(a) ascorbic acid; (b) silicone containing compounds in an amount of less than 50% by weight of the total composition; And (c) A non-aqueous composition comprising an essential oil, wherein the non-aqueous composition maintains at least 50% of the initial amount of ascorbic acid in the composition when the composition is stored at room temperature for at least one month. The composition of claim 1, wherein the ascorbic acid is particulate ascorbic acid. The composition of claim 2, wherein the particulate ascorbic acid comprises a particle size of less than about 50 μm. The composition of claim 2 wherein the particulate ascorbic acid is suspended in a silicon containing compound. The composition of claim 1 wherein the composition comprises from about 5% to about 15% by weight ascorbic acid of the total composition. The composition of claim 1, wherein the composition comprises less than 40% by weight of a silicon containing compound. The composition of claim 1 wherein the silicon containing compound is cyclomethicone. The essential oil of claim 1, wherein the essential oil is sesame oil, macadamia nut oil, tea tree oil, evening primrose oil, Spanish sage oil, Spanish rosemary oil, Coriander oil, Thyme ) Oil or Pimento berry oil. The composition of claim 1 wherein the composition does not comprise a nonvolatile oil. The composition of claim 1, wherein the composition is not an emulsion. The composition of claim 1, wherein the composition does not comprise emulsifiers or surfactants. The composition of claim 1, wherein at least 75% of the initial amount of ascorbic acid in the composition remains stable when the composition is stored at room temperature for at least one month. 13. The composition of claim 12, wherein at least 90% of the initial amount of ascorbic acid in the composition remains stable when the composition is stored at room temperature for at least one month. The composition of claim 1, wherein at least 50% of the initial amount of ascorbic acid in the composition remains stable when the composition is stored at room temperature for at least 6 months. 15. The composition of claim 14, wherein at least 75% of the initial amount of ascorbic acid in the composition remains stable when the composition is stored at room temperature for at least 6 months. The composition of claim 15, wherein at least 90% of the initial amount of ascorbic acid in the composition remains stable when the composition is stored at room temperature for at least 6 months. The composition of claim 1, wherein at least 50% of the initial amount of ascorbic acid in the composition remains stable when the composition is stored at room temperature for at least one year. 18. The composition of claim 17, wherein at least 75% of the initial amount of ascorbic acid in the composition remains stable when the composition is stored at room temperature for at least one year. 19. The composition of claim 18, wherein at least 90% of the initial amount of ascorbic acid in the composition remains stable when the composition is stored at room temperature for at least one year. The method of claim 1, (a) about 7% to about 10% by weight ascorbic acid; (b) about 20 wt% to about 30 wt% of a silicon containing compound; And (c) from about 40% to about 50% by weight of an essential oil or mixture of essential oils. The composition of claim 1, wherein the composition is included in a beauty product. (a) obtaining ascorbic acid, a silicon containing compound and an essential oil; And (b) a process for preparing a storage stable ascorbic acid composition comprising mixing ascorbic acid, a silicone containing compound and an essential oil to obtain a composition, wherein the composition is initially stored at room temperature for at least one month; How to keep more than 50% of the amount stable. The method of claim 22, wherein the ascorbic acid is particulate ascorbic acid. The method of claim 23, wherein the particulate ascorbic acid comprises a particle size of less than about 50 μm. The method of claim 23, wherein the particulate ascorbic acid is suspended in the silicon containing compound. The method of claim 22 wherein the composition comprises from about 5% to about 15% by weight of ascorbic acid of the total composition. The method of claim 22 wherein the composition comprises less than 50% by weight of a silicon containing compound. 28. The method of claim 27, wherein the silicon containing compound is cyclomethicone. 23. The method of claim 22, wherein the essential oil is selected from the group consisting of sesame oil, macadamia nut oil, tea tree oil, evening primrose oil, Spanish sage oil, Spanish rosemary oil, coriander oil, thyme oil or pimento berry oil. The method of claim 22, wherein the composition is a non-aqueous composition. The method of claim 22, wherein the composition does not comprise a nonvolatile oil. The method of claim 22, wherein the composition is not an emulsion. The method of claim 22, wherein the composition does not comprise emulsifiers or surfactants. The method of claim 22, wherein at least 75% of the initial amount of ascorbic acid in the composition remains stable when the composition is stored at room temperature for at least 1 month. 35. The method of claim 34, wherein at least 90% of the initial amount of ascorbic acid in the composition remains stable when the composition is stored at room temperature for at least one month. The method of claim 22, wherein at least 50% of the initial amount of ascorbic acid in the composition remains stable when the composition is stored at room temperature for at least 6 months. The method of claim 36, wherein at least 75% of the initial amount of ascorbic acid in the composition remains stable when the composition is stored at room temperature for at least 6 months. 38. The method of claim 37, wherein at least 90% of the initial amount of ascorbic acid in the composition remains stable when the composition is stored at room temperature for at least 6 months. The method of claim 22, wherein at least 50% of the initial amount of ascorbic acid in the composition remains stable when the composition is stored at room temperature for at least one year. The method of claim 39, wherein at least 75% of the initial amount of ascorbic acid in the composition remains stable when the composition is stored at room temperature for at least one year. The method of claim 40, wherein at least 90% of the initial amount of ascorbic acid in the composition remains stable when the composition is stored at room temperature for at least one year. The composition of claim 22, wherein the composition is (a) about 7% to about 10% by weight ascorbic acid; (b) about 20 wt% to about 30 wt% of a silicon containing compound; And (c) from about 40 wt% to about 50 wt% of an essential oil or mixture of essential oils. The method of claim 22, wherein the composition is included in the cosmetic product. A method of treating a skin disease comprising topically applying the composition of claim 1 to the skin, wherein said topical application treats the skin disease. 45. The method of claim 44, wherein the skin disease is fine lines or wrinkles in the skin.