CN111226946A - Bactericidal disinfectant and preparation method thereof - Google Patents
Bactericidal disinfectant and preparation method thereof Download PDFInfo
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- CN111226946A CN111226946A CN202010081077.1A CN202010081077A CN111226946A CN 111226946 A CN111226946 A CN 111226946A CN 202010081077 A CN202010081077 A CN 202010081077A CN 111226946 A CN111226946 A CN 111226946A
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/64—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with three nitrogen atoms as the only ring hetero atoms
- A01N43/647—Triazoles; Hydrogenated triazoles
- A01N43/653—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/30—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests characterised by the surfactants
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
- A01N37/34—Nitriles
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Abstract
The invention provides a sterilization disinfectant, which comprises the following raw materials in parts by weight: targeting agent: 5-10; and (3) bactericide: 30-60 parts of; penetrant: 1-5; a crosslinking agent: 1-5. The preparation method comprises the following steps: selecting a targeting agent, a bactericide, a penetrating agent and a cross-linking agent which are powder materials in parts by weight, and fully mixing in a powder mixer to form a mixture A; injecting deionized water and the mixture A into a high-speed disperser according to the weight ratio of 6-10:1, slowly adding the mixture A, uniformly stirring and dispersing for 60-90 minutes to prepare a thick mixed solution B; and transporting the mixed solution B to a use site, and stirring and diluting the mixed solution B and clean water according to the volume ratio of 1:10-1000 to prepare the liquid sterilizing disinfectant. The invention can greatly improve the speed of sterilization and disinfection, reduce the dosage, not only can kill fungi and germs, but also has strong killing effect on intractable viruses and spores, and is a high-efficiency, broad-spectrum and strong-killing-capacity disinfection product.
Description
Technical Field
The invention belongs to the technical field of disinfectants, and particularly relates to a bactericidal disinfectant applied to livestock breeding industry, aquaculture industry, silkworm production, medical treatment and public places and a preparation method thereof.
Background
In the current disinfectant market, disinfectants such as chlorine preparations, iodine preparations, aldehydes, oxidation and the like have advantages and disadvantages in effect, can effectively kill germs, fungi and bacteria, but have small effect on viruses; however, disinfectants that kill viruses do not have good spore killing effect; although the disinfectants imported from abroad have certain killing power on fungi, bacteria, viruses and spores, the disinfectants are influenced by factors such as temperature, climate, pH value and the like.
In recent years, "sars", avian influenza, foot-and-mouth disease, and other serious epidemics have frequently occurred worldwide. Seriously endangering human survival and health, and causing great loss to the development of society and the lives and properties of people. The prevention and control of epidemic spread and occurrence have become a major topic of health and epidemic prevention organizations and scientific research institutions of all countries. Disinfectants are increasingly showing their importance and urgency as a primary material for controlling epidemics. With the general improvement of people's disinfection consciousness, the use amount of the disinfectant is continuously increased, and meanwhile, higher requirements are put forward on the disinfection effect, the use method, the use range and the like of the disinfectant. The novel, broad-spectrum, powerful and economical disinfectant is urgently needed, and the requirements of people on production and life are met. The development of high-efficiency and broad-spectrum disinfectants is imperative.
Disclosure of Invention
The invention aims to overcome the defects of the prior art, and firstly provides a chitosan bromotebuconazole sterilization disinfectant which can be applied to livestock breeding industry, aquaculture industry, silkworm production, medical treatment and public places, so that the sterilization speed can be greatly improved, and the dosage can be reduced.
The invention provides a sterilizing disinfectant, which comprises the following raw materials in parts by weight: targeting agent: 5-10; and (3) bactericide: 30-60 parts of; penetrant: 1-5; a crosslinking agent: 1-5.
Further, the targeting agent can be hydroxypropyl chitosan; the bactericide can be selected from 2, 2-dibromo-3-cyanopropionamide and/or tebuconazole; the penetrating agent can be decyne diol or pentanediol; the cross-linking agent can be sodium carboxymethyl cellulose.
The preparation method of the sterilizing disinfectant comprises the following steps:
s1, selecting a targeting agent, a bactericide, a penetrating agent and a cross-linking agent which are powder materials according to parts by weight;
s2, fully mixing the raw materials in a powder mixer to form a mixture A;
s3, weighing deionized water and the mixture A according to the weight ratio of 6-10:1, then injecting the deionized water into a high-speed disperser, slowly adding the mixture A, uniformly stirring and dispersing for 60-90 minutes to prepare a thick mixed solution B;
s4, transporting the mixed liquid B to a use site, stirring and diluting the mixed liquid B and clean water according to the volume ratio of 1:10-1000, and then preparing the liquid sterilizing disinfectant.
The sterilization disinfectant causes the fungus Extracellular Polymeric Substance (EPS) to be damaged and released through the oxidative lysis, and the active DBNPA molecules quickly act on the protein of the microbial cell membrane to stop the normal oxidation reduction of the cell. Its branch can selectively brominate or oxidize special enzyme metabolite of microbe to finally result in cell death, and it not only can kill fungus and germ, but also has strong killing action to intractable virus and spore, and is a high-effective broad-spectrum disinfecting product with strong killing power. Meanwhile, the components of the disinfectant are environment-friendly, non-toxic and harmless, the preparation process is simple and convenient, the defects of large using amount, serious equipment loss corrosion, potential harm to the environment and the like of the traditional disinfectant are avoided, and the disinfectant has technical advantages and excellent popularization value compared with the existing disinfectant.
Detailed Description
In order to make the objects, technical solutions and advantages of the present invention more apparent, the present invention is further described in detail with reference to the following embodiments. It should be understood that the specific embodiments described herein are merely illustrative of the invention and are not intended to limit the invention.
The embodiment of the invention firstly provides a sterilization disinfectant, which comprises the following raw materials in parts by mass: targeting agent: 5-10; and (3) bactericide: 30-60 parts of; penetrant: 1-5; a crosslinking agent: 1-5.
In the raw material components, the targeting agent can be solid hydroxypropyl chitosan (HPCS); the bactericide can be solid 2, 2-dibromo-3-cyanopropionamide (DBNPA) and/or solid tebuconazole; the osmotic agent can be solid decyne diol or solid pentanediol; the cross-linking agent can be solid sodium carboxymethyl cellulose, and the balance is water. In the above raw material components, the targeting agent, the bactericide, the penetrating agent and the cross-linking agent may be selected from solid raw materials or liquid raw materials as required, and the raw materials are not limited to the above list, and may be raw materials with similar properties of each component, which are all the protection ranges of the bactericidal disinfectant of the present invention, and are not described herein again.
The sterilizing disinfectant provided by the invention selects hydroxypropyl chitosan as a targeting agent, leads the bactericide 2.2-dibromo-3-cyanopropionamide and/or tebuconazole as main components, selectively reacts with bacterial cells of a target tissue, and meanwhile, by means of a penetrating agent, all raw materials can be controllably distributed on the cell walls of microorganisms, and active DBNPA and/or tebuconazole molecules quickly act on proteins of the cell membranes of the microorganisms, so that the normal oxidation reduction of the cells is stopped. Its branching can also selectively brominate or oxidize specific enzyme metabolites of the microorganism, ultimately leading to cell death.
The specific mechanism is as follows: chitosan is used as a targeting agent, the main components of the targeting bactericide 2, 2-dibromo-3-cyanopropionamide and/or tebuconazole selectively react with target histiocytes, so that the bactericide can be conveyed to a target area of a cell wall to the maximum extent and can be controllably distributed on the cell wall, the bactericide is preferentially enriched on the cell wall of bacteria to increase the concentration of the bactericide, the time for the action of the bactericide and the target histiocytes is shortened, the bactericide specially reacts with the bacterial cells, and the wall breaking effect of the bacterial cells can be obviously improved. The chitosan targeting effect is closely related to the electropositivity of the chitosan, because the cell surface has negative charges, the chitosan can be adsorbed to the cell surface to neutralize the charges, and the amino group with positive charges formed in an acidic environment has affinity with somatic cells, and the targeting way is because the cell surface has a protein called mannose receptor which has strong affinity to mannose. Chitosan also alters the flux and permeability of a large number of microbial cell membranes in water, caused by the interaction of its positively charged groups with negatively charged groups on the microbial cell surface. Chitosan has a high affinity for microbial DNA, can enter the nucleus, interact with negatively charged DNA, and affect DNA replication and RNA transcription. The killing mechanism for viruses is: because most viruses do not have cell membranes, when host cells of the viruses are damaged, mannoprotein on the cell surfaces cannot provide living spaces for the viruses after being damaged, and therefore, the effects of indirectly killing the viruses are achieved.
2.2-dibromo-3-cyanopropionamide (DBNPA) is used as an organic bromine bactericide, has broad-spectrum bactericidal performance, and has good killing effects on bacteria, fungi, yeasts, algae, biological slime, pathogenic microorganisms threatening human health and the like. DBNPA is characterized by extremely high sterilization speed and high efficiency, and the sterilization rate can reach more than 99 percent in 5-10 minutes. Under the guiding and matching of hydroxypropyl chitosan, 2-dibromo-3-cyanopropionamide (DBNPA) is used as an organic bromine bactericide, molecules can be conveyed to a cell wall target region to the maximum extent, the bactericide is preferentially enriched on a cell wall, rapidly penetrates through a microbial cell membrane and acts on a protein group of the microbial cell membrane, normal oxidation reduction of cells is stopped, the acting time of the bactericide and target tissue cells is shortened, and branches of the bactericide can selectively bromize or oxidize special enzyme metabolites of the microbes to finally cause cell death. Its branching can also selectively brominate or oxidize specific enzyme metabolites of the microorganism, ultimately leading to cell death. Tebuconazole is an agricultural azole fungicide and also inhibits CYP51, and the IC50 values for Candida albicans CYP51(CaCYP51) and segmented human CYP51 (delta 60HsCYP51) are 0.9 and 1.3 mu M, respectively. Tebuconazole is a triazole bactericidal pesticide with high efficiency, broad spectrum and systemic property, has three functions of protection, treatment and eradication, has the characteristics of wide bactericidal spectrum, better systemic conductivity, longer lasting period and long lasting period. In the embodiment of the invention, the 2, 2-dibromo-3-cyanopropionamide and the tebuconazole are used as bactericides and can be selected according to different requirements, and the 2, 2-dibromo-3-cyanopropionamide and the tebuconazole are adopted for sterilization in a matching way, so that the effect that 1+1 is more than 2 can be achieved, and the broad spectrum performance of the chitosan bromocomplex tebuconazole bactericidal disinfectant is enhanced. When the 2, 2-dibromo-3-cyanopropionamide and the tebuconazole are used in a matching way, the ratio of the tebuconazole to the 2, 2-dibromo-3-cyanopropionamide to the tebuconazole is 10:0.5-1 when the tebuconazole is used in a matching way because the tebuconazole has a strong sterilization effect.
Decyne glycol is used as a penetrating agent, is a non-ionic surfactant, has low molecular weight, high dispersibility, low toxicity, high polarity and hydrophilicity, can reduce the dynamic surface tension of a system, and has high hydrophobicity; meanwhile, the decyne glycol has stable performance, has strong affinity to the metal surface, is easy to adsorb on the metal surface, and is beneficial to removing bacteria adhered to the metal wall in a water system. Similarly, pentane-1, 2-diol is a straight chain diol with significant polarity and non-polarity, and this particular charge distribution gives it unique characteristics and versatility that can improve its stability, taking advantage of its polar and non-polar effects and its good solubilizing effect in the present invention.
Sodium carboxymethylcellulose (CMC) belongs to anionic cellulose ethers, is white or yellowish flocculent fiber powder or white powder in appearance, is odorless and tasteless, and is nontoxic; it is easily dissolved in cold water or hot water to form a transparent solution with certain viscosity. The solution is neutral or slightly alkaline, insoluble in organic solvent such as ethanol, diethyl ether, isopropanol, acetone, etc., and soluble in 60% ethanol or acetone solution. The solution is stable at a pH value of 2-10, the pH value is lower than 2, solids are separated out, and the viscosity is reduced when the pH value is higher than 10. The color change temperature is 227 ℃, the carbonization temperature is 252 ℃, and the surface tension of the 2 percent aqueous solution is 71 mn/n. Carboxymethyl cellulose (CMC) is obtained after carboxymethylation of cellulose, and an aqueous solution of the carboxymethyl cellulose has the effects of thickening, film forming, adhesion, water retention, colloid protection, emulsification, suspension and the like, is widely applied to industries such as petroleum, food, medicine, textile, papermaking and the like, is one of the most important cellulose ethers, and is used as a cross-linking agent for compatibility in the invention.
The chitosan is used as the targeting agent, targets mannose with negative charge on the cell surface by utilizing the electropositive way, guides the bactericide to be conveyed to a target area of a cell wall at the fastest speed, enriches the bactericide on the cell wall in a controllable concentration, selectively reacts with target tissue cells, rapidly penetrates through microbial cells to enter cell nucleus, interacts with DNA with the DNA with negative charge, influences the replication of the DNA and the transcription of the RNA, selectively bromizes or oxidizes special enzyme metabolites of the microbes by virtue of bromoquaternary ammonium salt branches, destroys the integrity of the cell membrane and enables intracellular substances (Na +, K +, PO43-, DNA, RNA and the like) to be released, increases the ion permeability of bacteria, simultaneously reduces the dynamic surface tension and the adhesiveness of a system by virtue of the penetrating agent, utilizes the good hydrophobicity of the sterilizing agent, reduces the affinity with water, shortens the time of the action of the bactericide on the target tissue cells, improves the cell membrane killing effect, enables a large amount of intracellular substances and β substances to be capable of rapidly killing bacteria cells by utilizing the penetrating agent, and enables the bactericide to have good synergistic effect of enhancing the cell wall breaking effect of killing the biological cell membrane and the targeted bactericide and the extracellular disinfectant to be capable of enhancing the cell wall breaking the cell wall of killing effect of causing the cell wall and the cell wall of the bactericide.
Further, the preparation method of the embodiment of the disinfectant comprises the following steps:
s1, selecting the raw materials of the targeting agent, the bactericide, the penetrating agent and the cross-linking agent as powder materials according to the parts by weight.
In the step, the targeting agent is solid hydroxypropyl chitosan; the bactericide selects solid 2, 2-dibromo-3-cyanopropionamide and/or solid tebuconazole; the penetrating agent is solid decyne diol or pentanediol; the cross-linking agent is solid sodium carboxymethylcellulose, can be powder, and has a particle size below 200 meshes.
If the bactericide is selected from 2.2-dibromo-3-cyanopropionamide and tebuconazole for use, the 2.2-dibromo-3-cyanopropionamide and the tebuconazole can be mixed according to the proportion of 10:0.5-1 due to certain viscosity of the solid tebuconazole, and then the mixture is mixed with a targeting agent, namely hydroxypropyl chitosan, a penetrating agent, namely decyne glycol or pentanediol, and a crosslinking agent, namely sodium carboxymethylcellulose to form a mixture A.
S2 the raw materials were mixed thoroughly in a powder mixer to form a mixture a.
S3, weighing the deionized water and the mixture A according to the weight ratio of 6-10:1, then injecting the deionized water into a high-speed disperser, slowly adding the mixture A while rotating the high-speed disperser, uniformly stirring and dispersing for 60-90 minutes to prepare a thick mixed solution B.
In this step, after injecting the deionized water into the high-speed disperser, the high-speed disperser is rotated at a low speed of 500-. After the mixture A is completely added, the high-speed disperser is rotated at a high speed of 3000-3500 rpm and stirred for 50-70 min.
The reason is that hydroxypropyl chitosan has low solubility in water, needs a certain time and has a viscosity requirement when being mixed with deionized water, and in addition, the organic bromine bactericide has low solubility in water, and the solubility of water needs to be improved by a penetrating agent (decyne glycol or pentanediol) to accelerate the dissolution of the organic bromine bactericide, so that a cross-linking agent and the bactericide are dissolved with a targeting agent. The mixture A is gradually and slowly added and stirred at low speed at the same time, so that the targeting agent and the organic bromine bactericide are dissolved in water. After the mixture A is completely added, the cross-linking agent sodium carboxymethyl cellulose can be uniformly dispersed to form suspension by high-speed stirring, so that the high-speed stirring is adopted in the subsequent step, and the raw materials can be fully and uniformly dispersed in water.
S4, transporting the mixed liquid B to a use site, stirring and diluting the mixed liquid B and clean water according to the volume ratio of 1:10-1000, and preparing the liquid disinfectant.
The prepared sterilizing disinfectant which is uniformly stirred is conveyed to a plastic barrel for packaging and standby application, the effective period is 60 days, and the effect of the sterilizing disinfectant can be influenced when the effective period is exceeded.
The concentration can be prepared according to an application object, and when the bactericide is used as a circulating cooling water system bactericide, the adding concentration is recommended to be 20-40 ppm; when the adhesive is used as a slime stripping agent, the recommended adding concentration is 30-50 ppm; when the compound is used as an algicide for killing algae, the suggested adding concentration is 50-70 ppm; when the composite material is used as a sludge wall breaking agent, the suggested adding concentration is 100-150 ppm.
The preparation method of the embodiment of the sterilizing disinfectant agent is characterized in that hydroxypropyl chitosan is used as a targeting agent, 2-dibromo-3-cyanopropionamide and tebuconazole are used as sterilizing agents, decynediol or pentanediol is used as a penetrating agent, sodium carboxymethylcellulose (CMC) is used as a cross-linking agent, and the sterilizing disinfectant agent is prepared by compounding the hydroxypropyl chitosan, the 2, 2-dibromo-3-cyanopropionamide and the tebuconazole according to a certain sequence and proportion. The whole process is simple, special equipment is not needed, the process parameters are easy to control, and the cost is low. It is characterized in that:
1. the chitosan bromopiconazole sterilization disinfectant has high-efficiency sterilization disinfectant, and has high-efficiency killing effect on common pathogenic microorganisms and unicellular organisms (including staphylococcus aureus, escherichia coli, bacillus subtilis, legionella, mould, fungi, hepatitis B virus, atypical pneumonia virus, AIDS virus, HIV virus, influenza virus, algae, flea and the like);
2. the chitosan bromopiconazole disinfectant has small dosage, and the common concentration unit is one hundred thousand dosage; the effective bromine content in the water body is 2-5mg/L, and the sterilization effect of more than 99.9 percent can be achieved, and the usage amount of the effective bromine content of 200mg/L can achieve the sterilization effect of more than 99 percent within 5-10 minutes in the use of solid sterilization;
3. the stability is good: the chitosan bromotebuconazole bactericidal disinfectant has good adaptability to the temperature and the pH value of water and environment, the temperature is in the range of 15-35 ℃, the pH value is in the range of 2-9, the chitosan bromotebuconazole bactericidal disinfectant has good disinfection effect, is stable in the water, and has a natural degradation speed of 52% within 10 hours (according to the experimental test result guided by professor of microorganism of life science institute of Shenzhen university); in contrast, chlorine dioxide, trichloro and other chlorine-containing disinfectants generally have the concentration reduced to be incapable of being used for replenishment within 4 hours, and the residual chlorine amount needs to be kept to ensure the disinfection effect;
4. the chitosan bromotebuconazole disinfectant has long lasting action time: as the 1, 3-dibromo-5, 5-dimethylhydantoin has a certain slow release effect in water, the chitosan bromoquaternary ammonium salt efficient disinfectant for sterilizing can continuously generate effective sterilizing factors in water within a certain time, and has longer most use time and economic value of repeated use; meanwhile, the antibacterial agent also has a certain antibacterial effect;
5. the chitosan bromopiconazole disinfectant has low comprehensive use cost, and because the usage amount is small and the action time is long, the dosage is greatly reduced, the disinfection time interval is increased and the comprehensive cost is reduced in the common use process;
6. the main components of the chitosan bromojulozolid tebuconazole sterilizing disinfectant are respectively degraded into carbon dioxide, ammonia gas, water and trace bromine gas and bromide after being disinfected, the bromine and the bromide are natural components of natural water and have no harmful residues in the water and the disinfected substances, according to the experimental determination of a third party laboratory in Shenzhen City, 10min after the disinfection of mango and pawpaw is carried out, the residual bromine content in 100g of fruits is lower than 0.35mg and is lower than the national standard, and the bromine content can be further reduced after the washing and the airing;
7. the chitosan bromocyclopentazolol sterilizing disinfectant does not produce irritant gas, has no stimulation to skin, is nontoxic and pollution-free, has low release amount of ammonia gas and carbon dioxide, and has no pollution to the environment.
Comparison table of chitosan bromopiconazole disinfectant and other common disinfectants
The application field of the sterilizing disinfectant of the invention is as follows:
can quickly kill bacteria, fungi, yeasts, heterotrophic bacteria and sulfate reducing bacteria, can also effectively kill pathogens of toxic bacteria (including legionnaires disease-legionella pneumophila), has excellent killing, inhibiting and stripping effects on algae and biological slime, and is a high-performance industrial bactericide.
Representative application areas include the following:
(1) a recirculating cooling water system;
(2) pulp, paper making and board production;
(3) a direct current industrial water system;
(4) an industrial air scrubber system;
(5) oil field and oil field flooding systems;
(6) a water-based metalworking fluid system.
The present invention will be described in further detail with reference to examples.
The first embodiment is as follows:
s1, mixing 2, 2-dibromo-3-cyanopropionamide serving as a bactericide and tebuconazole in a ratio of 10:1 to prepare 60kg of powder, and then placing 10kg of hydroxypropyl chitosan serving as a targeting agent, 5kg of decynediol serving as a penetrating agent and 5kg of sodium carboxymethyl cellulose serving as a crosslinking agent in a powder mixer for fully mixing to form a mixture A;
s2, injecting 500kg of deionized water into a high-speed disperser, adding the mixture A under stirring at the rotating speed of the high-speed disperser of 1000 rpm for about 20 minutes, and after the mixture A is completely added, rotating the high-speed disperser at the high speed of 3500-rpm, and stirring for 70 minutes at the same time to uniformly disperse the powder of each component to prepare a thick mixed solution B.
S3, transporting the mixed solution B to a use site, stirring and diluting the mixed solution B and clean water according to the proportion of adding concentration of 20-40 ppm to prepare a liquid disinfectant, and adding the liquid disinfectant into a circulating cooling system for use.
And (3) detection results:
during detection, the content of sulfate reducing bacteria in the cooling water system is more than 103Per mL to 104one/mL, saprophytic bacteria content is more than 103Per mL to 104each/mL, iron bacteria content greater than 102Per mL to 103And (4) adding no bactericide into the water sample per mL.
(1) Detection method
High performance liquid chromatography is adopted.
A sample is extracted from cooling water of a circulating cooling system added with the sterilizing disinfectant, the sample is dissolved by a mobile phase (a mixed solution of methanol and water), then a sample solution is injected into a chromatographic system, a 220nm UV detector is used for detection, and the amount is measured by an area normalization method.
(2) Detection reagent
Methanol: special high-grade liquid chromatography;
water: the specification of the secondary water in GB/T6682 is met;
(3) detection instrument
Liquid chromatograph: a UV-220 nm detector is arranged;
a quantitative sample injection valve: 20 mu L of the solution;
a chromatography workstation; a chromatographic column tube: 150mm x 3.9mm (inside diameter), stainless steel; column packing: CHEMCOSOB 5-ODS-H5 μm;
microsyringe: 100 μ L.
(4) Chromatographic conditions
Column temperature: room temperature;
mobile phase: methanol + water-50 +50(v + v);
flow rate: 1.0 mL/min.
(5) Analytical procedure
Accurately weighing 0.1-0.2 g (accurate to 0.0001g) of sample in a 50ml volumetric flask, dissolving with a mobile phase, degassing for about 30min with ultrasonic waves, and analyzing by sample injection after the instrument is stable.
(6) Results and analysis:
the sterilization rate of sulfate reducing bacteria is more than or equal to 97.8 percent;
the sterilization rate of saprophytic bacteria is more than or equal to 98.2 percent;
the sterilization rate to iron bacteria is more than or equal to 98.5 percent;
the number of residual bacteria of sulfate reducing bacteria is less than or equal to 0.5 multiplied by 101one/mL.
According to the detection results, the embodiment has strong killing rate on various bacteria in the cooling water.
The embodiment can be used as a sterilizing disinfectant to be put into circulating cooling water systems of power plants, chemical plants, cokes and oil refineries, particularly open circulating cooling systems, and dust, bacteria, microorganisms and the like easily enter the circulating water due to the fact that water flow is in contact with the atmosphere, and a large amount of bacteria and microorganisms can be bred. The sterilization disinfectant of the embodiment is put into the pot, so that the sterilization disinfectant has a very good sterilization and disinfection effect.
Example 2:
s1, placing 8kg of hydroxypropyl chitosan powder serving as a targeting agent, 40kg of 2.2-dibromo-3-cyanopropionamide powder serving as a bactericide, 2kg of decynediol powder serving as a penetrating agent and 2kg of sodium carboxymethylcellulose powder serving as a crosslinking agent in a powder mixer for fully mixing to form a mixture A;
s2, injecting 400kg of deionized water into a high-speed disperser, adding the mixture A under stirring at the high-speed disperser rotating speed of 800 revolutions per minute for about 15 minutes, and after the mixture A is completely added, rotating the high-speed disperser at the high speed of 3000 revolutions per minute, and stirring for 50 minutes at the same time to uniformly disperse the powder of each component to prepare a thick mixed solution B.
S3, transporting the mixed solution B to a use site, stirring and diluting the mixed solution B and clean water according to the proportion of adding concentration of 30-50 ppm, and using the diluted mixed solution B and clean water to prepare a liquid disinfectant serving as a slime stripping agent.
The detection process of the embodiment is basically consistent with that of the embodiment, the killing rate of sulfate reducing bacteria, nitrobacteria, nitrosobacteria and the like in water is higher than 98.5%, and the method has a strong killing effect.
This embodiment is used as slime stripper and is system in circulative cooling system, can effectively peel off and is stained with the bacterium slime on the cooling circulation system pipeline inner wall, has good slime stripping action and certain dispersion, infiltration, and can effectively restrain the slime and increase, all has fine bactericidal effect in the pH value within range of difference, makes the slime discharge along with rivers after droing, reaches powerful peeling off and abluent purpose.
Example 3:
s1 placing 5kg of targeting agent hydroxypropyl chitosan powder, 30kg of bactericide tebuconazole powder, 1kg of penetrating agent pentanediol powder and 1kg of cross-linking agent carboxymethylcellulose sodium powder in a powder mixer for fully mixing to form a mixture A;
s2, 450kg of deionized water is injected into a high-speed disperser, the mixture A is added under the condition of stirring at the rotating speed of the high-speed disperser of 500 revolutions per minute for about 15 minutes, and after the mixture A is completely added, the high-speed disperser is rotated at a high speed of 3000-revolutions per minute and stirred for 50 minutes at the same time, so that the powder of each component is uniformly dispersed, and thick mixed liquid B is prepared.
S3, transporting the mixed liquid B to a use site, stirring and diluting the mixed liquid B and clean water according to the proportion of adding concentration of 50-70 ppm, and using the mixed liquid B and the clean water to prepare the liquid disinfectant for killing algae, wherein the liquid disinfectant is used as an algicide for killing algae.
The bactericidal disinfectant is put into open circulating systems such as a circulating cooling system of a nuclear power station, industrial circulating cooling water, a central air-conditioning cooling tower and the like as a bactericidal disinfectant, so that the breeding of bacteria and algae in the circulating cooling water system can be controlled, most of microorganisms are killed, the bactericidal rate is 99%, the bactericidal effect is strong, the permeability and the dispersibility are quite good, and the algae propagation in water can be effectively eliminated.
Example 4:
s1 putting 10kg of hydroxypropyl chitosan powder serving as a targeting agent, 50kg of 2.2-dibromo-3-cyanopropionamide powder serving as a bactericide, 3kg of decynediol powder serving as a penetrating agent and 3kg of sodium carboxymethylcellulose powder serving as a crosslinking agent into a powder mixer for fully mixing to form a mixture A;
s2, 600kg of deionized water is injected into a high-speed disperser, the mixture A is added under the condition that the rotating speed of the high-speed disperser is 1000 revolutions per minute, the time is about 20 minutes, after the mixture A is completely added, the high-speed disperser rotates at a high speed of 3500 revolutions per minute, and the mixture A is stirred for 60 minutes, so that the powder of each component is uniformly dispersed, and thick mixed liquid B is prepared.
S3, transporting the mixed liquid B to a use site, stirring and diluting the mixed liquid B and clean water according to the proportion of adding concentration of 100-150 ppm, and using the mixed liquid B and the clean water to prepare a liquid sterilization disinfectant which is used as a sludge wall breaking agent and is used for reducing the amount of the water-containing sludge.
The embodiment is applied to a Shenzhen certain water quality purification plant as a sludge wall breaking agent, after sludge is conditioned by the sludge wall breaking agent with different components, the moisture content of a sludge cake discharged from the Shenzhen certain water quality purification plant can be respectively 59.3%, 53.6% and 49.7% through the middle test plate frame squeezing for 20min, and the moisture content of the sludge cake is averagely less than 60%, so that the requirement of the manufacturer on each index in the sludge conditioning process can be met.
The above-described embodiments of the present invention are merely exemplary and not intended to limit the present invention, and those skilled in the art may make various modifications, substitutions and improvements without departing from the spirit of the present invention.
Claims (9)
1. The sterilizing disinfectant is characterized by comprising the following raw materials in parts by weight:
targeting agent: 5-10; and (3) bactericide: 30-60 parts of; penetrant: 1-5; a crosslinking agent: 1-5.
2. The disinfectant of claim 1 wherein said targeting agent is hydroxypropyl chitosan.
3. The disinfectant according to claim 1, wherein said disinfectant is 2, 2-dibromo-3-cyanopropionamide and/or tebuconazole.
4. The bactericidal disinfectant according to claim 3, wherein the ratio of the 2, 2-dibromo-3-cyanopropionamide to the tebuconazole is 10: 0.5-1.
5. The germicidal sterilant of claim 1 wherein the penetrant is selected from the group consisting of decynediol and pentanediol.
6. The germicidal sterilant of claim 1 wherein the cross-linking agent is sodium carboxymethylcellulose.
7. A process for the preparation of a germicidal sterilant according to any of the claims 1 to 6 comprising the steps of:
s1, selecting a targeting agent, a bactericide, a penetrating agent and a cross-linking agent which are powder materials according to parts by weight;
s2, fully mixing the raw materials in a powder mixer to form a mixture A;
s3, weighing deionized water and the mixture A according to the weight ratio of 6-10:1, then injecting the deionized water into a high-speed disperser, slowly adding the mixture A, uniformly stirring and dispersing for 60-90 minutes to prepare a thick mixed solution B;
s4, transporting the mixed liquid B to a use site, stirring and diluting the mixed liquid B and clean water according to the volume ratio of 1:10-1000, and then preparing the liquid sterilizing disinfectant.
8. The method for preparing a germicidal sterilant according to claim 7 wherein: when the bactericide is a combination of 2.2-dibromo-3-cyanopropionamide and tebuconazole, the 2.2-dibromo-3-cyanopropionamide and the tebuconazole are mixed according to the proportion and then mixed with the targeting agent, the penetrating agent and the crosslinking agent to form a mixture A.
9. The method of preparing a germicidal sterilant according to claim 7 or 8 wherein: in the step S3, after injecting the deionized water into the high-speed disperser, the high-speed disperser is rotated at a speed of 500-.
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