CN103520437A - Chinese medicinal patch for treating dysmenorrhea, and preparation method and application thereof - Google Patents
Chinese medicinal patch for treating dysmenorrhea, and preparation method and application thereof Download PDFInfo
- Publication number
- CN103520437A CN103520437A CN201310480497.7A CN201310480497A CN103520437A CN 103520437 A CN103520437 A CN 103520437A CN 201310480497 A CN201310480497 A CN 201310480497A CN 103520437 A CN103520437 A CN 103520437A
- Authority
- CN
- China
- Prior art keywords
- parts
- ointment
- containing body
- preparation
- chinese
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Medicinal Preparation (AREA)
Abstract
The invention relates to a Chinese medicinal patch for treating dysmenorrhea, and a preparation method and an application thereof. An ointment-containing body of the Chinese medicinal patch comprises the following components in parts by weight: 8 to 10 parts of Chinese medicinal extract, 4 to 6 parts of kaolin, 10 to 12 parts of aerosil, 2 to 4 parts of glycerine, 4 to 6 parts of menthol, 16 to 20 parts of sodium alginate and 0.5 to 1 part of titanium dioxide. The Chinese medicinal extract is prepared from the following raw medicaments in parts by weight: 14 to 16 parts of cattail pollen, 4 to 6 parts of frankincense, 4 to 6 parts of myrrh and 5 to 6 parts of dragon blood. The Chinese medicinal patch has definite curative effects on dysmenorrhea, an overall effective rate of 98 percent and insignificant toxic and side effects, is more convenient to use and prepare, high in patient compliance and low in cost, and comprises a few Chinese medicinal components, the whole blood specific viscosity and the plasma specific viscosity can be remarkably lowered, and the ratio of PGE2 (prostaglandin E2) to PGF2a (prostaglandin F2a) is increased.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition for the treatment of dysmenorrhea, specifically, is a kind of Chinese herbs paste for the treatment of dysmenorrhea and its preparation method and application.
Background technology
When primary dysmenorrhea (PD) is menstruation, stomachache, without pelvic cavity pathologic condition, generally belongs to the traditional Chinese medical science " unmarried girl's dysmenorrhea " category, and head sees " leukorrhagia, menstrual disorders, the lower abdominal pain and fullness " of " Medical Treasures of the Golden Chamber married woman arteries and veins is demonstrate,proved and controlled ".Think now, its pathology is because the prostaglandin in menstrual endometrium increases suddenly, causes that hysterospasm shrinks, and causes uterus ischemia, the bad pain that occurs of local circulation.
Chinese periodical " practical Chinese medicine magazine ", in February, 2002, the 18th 2 phases of volume, the paper of publishing " supplemented myrrh dragon's blood tablet treatment primary dysmenorrhea observation of curative effect ", disclose from premenstrual 1 week of the moon within 1～2 day, take supplemented myrrh dragon's blood tablet (Rhizoma Curcumae, Olibanum, Myrrha, Rhizoma Sparganii, Radix Cynanchi Paniculati, Rhizoma Corydalis, Oletum Trogopterori, Sanguis Draxonis, Pollen Tyjphae) through row, treated continuously after 3 months, total effective rate is 96%, plasma viscosity significantly declines, urine PGE
2/ PGF
2aratio significantly rises, and shows that it can improve blood viscosity, regulates prostaglandin level.
Chinese periodical " Journal of Traditional Chinese Medicine " the 35th the 2nd phase of volume in 1994, the paper of publishing " clinical research of supplemented myrrh dragon's blood soup treatment primary dysmenorrhea ", supplemented myrrh dragon's blood soup recipe is disclosed: Pollen Tyjphae (bag) 30g, Oletum Trogopterori (parched) (bag) 15g, Pericarpium Citri Reticulatae Viride 6g, Rhizoma Sparganii 15g, Rhizoma Curcumae 15g, Fructus Crataegi 12g, Olibanum 3g, Myrrha 3g, Sanguis Draxonis powder 2g, premenstrual 2 weeks start to take medicine, oral standard preparation 50ml, every day 2 times, take continuously 15 days extremely through damp the 1st day.Through treatment in 3 months, the recent cure rate 41.3% of supplemented myrrh dragon's blood soup group, obviously reduced PGF in menses
2a, PGE
2content and ratio, and significantly reduce the content of peripheral blood midluteal phase E2, rising corpus luteum progesterone content in latter stage.
But the supplemented myrrh dragon's blood soup of above-mentioned treatment dysmenorrhea all has following defect: 1) Chinese medicinal components is too much, be not easy to preparation, cost is higher; 2) be all oral administration, medication is inconvenient, simultaneously relatively large to the side effect of human body.Therefore need that a kind of Chinese medicinal components is relatively less badly, the medicine of convenient drug administration and treatment dysmenorrhea evident in efficacy, but about this class medicine, have not been reported at present.
Summary of the invention
The object of the invention is for deficiency of the prior art, a kind of Chinese herbs paste for the treatment of dysmenorrhea is provided.
One object more of the present invention is that the preparation method of above-mentioned Chinese herbs paste is provided.
Another object of the present invention is that the purposes of above-mentioned Chinese herbs paste is provided.
For achieving the above object, the technical scheme that the present invention takes is:
A kind of Chinese herbs paste for the treatment of dysmenorrhea, in the ointment-containing body of described Chinese herbs paste, each component and weight portion thereof are: Chinese medical concrete 8-10 part, Kaolin 4-6 part, micropowder silica gel 10-12 part, glycerol 2-4 part, menthol 4-6 part, sodium alginate 16-20 part, titanium dioxide 0.5-1 part, described Chinese medical concrete is made by the crude drug of following weight portion: Pollen Typhae 14-16 part, Olibanum 4-6 part, Myrrha 4-6 part, Sanguis Draxonis 5-6 part.
Preferably, described Chinese medical concrete is made by the crude drug of following weight portion: 15 parts of Pollen Typhaes, 5 parts of Olibanums, 5 parts of Myrrhas, 5 parts of Sanguis Draxonis.
Preferably, in the ointment-containing body of described Chinese herbs paste, each component and weight portion thereof are: 10 parts of Chinese medical concretes, 5 parts of Kaolin, 10 parts of micropowder silica gels, 3 parts of glycerol, 5 parts of menthols, 18 parts of sodium alginates, 1 part of titanium dioxide.
For realizing above-mentioned second object, the technical scheme that the present invention takes is:
The preparation method of Chinese herbs paste as above, comprises the following steps:
A) get Pollen Typhae, Olibanum, Myrrha water decoction 4-8 hour, then add Sanguis Draxonis to decoct 2-3 hour, filter post-heating and be concentrated into extractum;
B) add sodium alginate after Kaolin, micropowder silica gel are mixed with glycerol, menthol, stir;
C) Chinese medical concrete that adds step a) to prepare in the substrate of preparing to step b) adds titanium dioxide simultaneously, and under room temperature, 60-80rpm/min stirs, and obtains ointment-containing body;
D) ointment-containing body of being prepared by step c) is coated on backing layer and protective layer.Described backing layer can be non-woven fabrics, artificial cloth etc.; Described protective layer can be separate paper, polyester film, polyethylene film etc.
For realizing above-mentioned the 3rd object, the technical scheme that the present invention takes is:
The application of Chinese herbs paste as above in the medicine of preparation treatment dysmenorrhea.
The invention has the advantages that:
1, Chinese herbs paste treatment dysmenorrhea determined curative effect of the present invention, can significantly reduce whole blood contrast viscosity and plasma viscosity, raising PGE
2/ PGF
2aratio, total effective rate, up to 98%, is better than oral administration route and take 30 parts of Pollen Tyjphae, 15 parts of Oletum Trogopterori (parched)s, 6 parts, Pericarpium Citri Reticulatae Viride, 15 parts of Rhizoma Sparganii, 15 parts of Rhizoma Curcumae, 12 parts of Fructus Crataegi, 3 parts of Olibanums, 3 parts of Myrrhas, 2 parts of patches of preparing as raw material of Sanguis Draxonis powder;
2, Chinese herbs paste use of the present invention is convenient, and toxic and side effects is little, and patient compliance is good;
3, its Chinese medicinal components of Chinese herbs paste of the present invention is few, is convenient to preparation, and cost is low.
The specific embodiment
Below the specific embodiment provided by the invention is elaborated.
embodiment 1 the present invention treats the Chinese herbs paste preparation () of dysmenorrhea
1, basic composition
Backing layer: non-woven fabrics;
Protective layer: polyester film;
Ointment-containing body is comprised of following weight portion material: 10 parts of Chinese medical concretes, 5 parts of Kaolin, 10 parts of micropowder silica gels, 3 parts of glycerol, 5 parts of menthols, 18 parts of sodium alginates, 1 part of titanium dioxide;
Chinese medical concrete is made by the crude drug of following weight portion: 15 parts of Pollen Typhaes, 5 parts of Olibanums, 5 parts of Myrrhas, 5 parts of Sanguis Draxonis.
2, preparation method
A) get Pollen Typhae, Olibanum, Myrrha water and decoct 6 hours, then add Sanguis Draxonis to decoct 3 hours, filter post-heating and be concentrated into extractum;
B) preparation of substrate: add sodium alginate after Kaolin, micropowder silica gel are mixed with glycerol, menthol, stir;
C) preparation of ointment-containing body: the Chinese medical concrete that adds step a) to prepare in the substrate of preparing to step b), add titanium dioxide simultaneously, under room temperature, 70rpm/min stirs 50min, obtains ointment-containing body;
D) coating of ointment-containing body: ointment-containing body prepared by step c) is coated on backing layer and protective layer, room temperature is placed 22h;
E) section;
F) packing.
embodiment 2 the present invention treat the Chinese herbs paste preparation (two) of dysmenorrhea
1, basic composition
Backing layer: artificial cloth;
Protective layer: separate paper;
Ointment-containing body is comprised of following weight portion material: 8 parts of Chinese medical concretes, 6 parts of Kaolin, 10 parts of micropowder silica gels, 4 parts of glycerol, 4 parts of menthols, 20 parts of sodium alginates, 0.5 part of titanium dioxide;
Chinese medical concrete is made by the crude drug of following weight portion: 14 parts of Pollen Typhaes, 6 parts of Olibanums, 4 parts of Myrrhas, 6 parts of Sanguis Draxonis.
2, preparation method
A) get Pollen Typhae, Olibanum, Myrrha water and decoct 8 hours, then add Sanguis Draxonis to decoct 2 hours, filter post-heating and be concentrated into extractum;
B) preparation of substrate: add sodium alginate after Kaolin, micropowder silica gel are mixed with glycerol, menthol, stir;
C) preparation of ointment-containing body: the Chinese medical concrete that adds step a) to prepare in the substrate of preparing to step b), add titanium dioxide simultaneously, under room temperature, 80rpm/min stirs 50min, obtains ointment-containing body;
D) coating of ointment-containing body: ointment-containing body prepared by step c) is coated on backing layer and protective layer, room temperature is placed 22h;
E) section;
F) packing.
embodiment 3 the present invention treat the Chinese herbs paste preparation (three) of dysmenorrhea
1, basic composition
Backing layer: non-woven fabrics;
Protective layer: polyester film;
Ointment-containing body is comprised of following weight portion material: 10 parts of Chinese medical concretes, 4 parts of Kaolin, 12 parts of micropowder silica gels, 2 parts of glycerol, 6 parts of menthols, 16 parts of sodium alginates, 1 part of titanium dioxide;
Chinese medical concrete is made by the crude drug of following weight portion: 16 parts of Pollen Typhaes, 4 parts of Olibanums, 6 parts of Myrrhas, 5 parts of Sanguis Draxonis.
2, preparation method
A) get Pollen Typhae, Olibanum, Myrrha water and decoct 4 hours, then add Sanguis Draxonis to decoct 3 hours, filter post-heating and be concentrated into extractum;
B) preparation of substrate: add sodium alginate after Kaolin, micropowder silica gel are mixed with glycerol, menthol, stir;
C) preparation of ointment-containing body: the Chinese medical concrete that adds step a) to prepare in the substrate of preparing to step b), add titanium dioxide simultaneously, under room temperature, 60rpm/min stirs 50min, obtains ointment-containing body;
D) coating of ointment-containing body: ointment-containing body prepared by step c) is coated on backing layer and protective layer, room temperature is placed 22h;
E) section;
F) packing.
embodiment 4 the present invention treat the Chinese herbs paste preparation (four) of dysmenorrhea
1, basic composition
Backing layer: non-woven fabrics;
Protective layer: polyethylene film;
Ointment-containing body is comprised of following weight portion material: 8 parts of Chinese medical concretes, 4 parts of Kaolin, 12 parts of micropowder silica gels, 4 parts of glycerol, 4 parts of menthols, 16 parts of sodium alginates, 1 part of titanium dioxide;
Chinese medical concrete is made by the crude drug of following weight portion: 14 parts of Pollen Typhaes, 4 parts of Olibanums, 6 parts of Myrrhas, 6 parts of Sanguis Draxonis.
2, preparation method
A) get Pollen Typhae, Olibanum, Myrrha water and decoct 6 hours, then add Sanguis Draxonis to decoct 2.5 hours, filter post-heating and be concentrated into extractum;
B) preparation of substrate: add sodium alginate after Kaolin, micropowder silica gel are mixed with glycerol, menthol, stir;
C) preparation of ointment-containing body: the Chinese medical concrete that adds step a) to prepare in the substrate of preparing to step b), add titanium dioxide simultaneously, under room temperature, 70rpm/min stirs 50min, obtains ointment-containing body;
D) coating of ointment-containing body: ointment-containing body prepared by step c) is coated on backing layer and protective layer, room temperature is placed 22h;
E) section;
F) packing.
embodiment 5 the present invention treat the Chinese herbs paste preparation (five) of dysmenorrhea
1, basic composition
Backing layer: non-woven fabrics;
Protective layer: polyester film;
Ointment-containing body is comprised of following weight portion material: 10 parts of Chinese medical concretes, 6 parts of Kaolin, 10 parts of micropowder silica gels, 2 parts of glycerol, 6 parts of menthols, 20 parts of sodium alginates, 0.5 part of titanium dioxide;
Chinese medical concrete is made by the crude drug of following weight portion: 16 parts of Pollen Typhaes, 6 parts of Olibanums, 4 parts of Myrrhas, 5 parts of Sanguis Draxonis.
2, preparation method
A) get Pollen Typhae, Olibanum, Myrrha water and decoct 8 hours, then add Sanguis Draxonis to decoct 2 hours, filter post-heating and be concentrated into extractum;
B) preparation of substrate: add sodium alginate after Kaolin, micropowder silica gel are mixed with glycerol, menthol, stir;
C) preparation of ointment-containing body: the Chinese medical concrete that adds step a) to prepare in the substrate of preparing to step b), add titanium dioxide simultaneously, under room temperature, 80rpm/min stirs 50min, obtains ointment-containing body;
D) coating of ointment-containing body: ointment-containing body prepared by step c) is coated on backing layer and protective layer, room temperature is placed 22h;
E) section;
F) packing.
embodiment 6 the present invention treat the Chinese herbs paste preparation (six) of dysmenorrhea
1, basic composition
Backing layer: non-woven fabrics;
Protective layer: polyester film;
Ointment-containing body is comprised of following weight portion material: 8 parts of Chinese medical concretes, 6 parts of Kaolin, 12 parts of micropowder silica gels, 2 parts of glycerol, 4 parts of menthols, 20 parts of sodium alginates, 1 part of titanium dioxide;
Chinese medical concrete is made by the crude drug of following weight portion: 14 parts of Pollen Typhaes, 6 parts of Olibanums, 6 parts of Myrrhas, 5 parts of Sanguis Draxonis.
2, preparation method
A) get Pollen Typhae, Olibanum, Myrrha water and decoct 4 hours, then add Sanguis Draxonis to decoct 3 hours, filter post-heating and be concentrated into extractum;
B) preparation of substrate: add sodium alginate after Kaolin, micropowder silica gel are mixed with glycerol, menthol, stir;
C) preparation of ointment-containing body: the Chinese medical concrete that adds step a) to prepare in the substrate of preparing to step b), add titanium dioxide simultaneously, under room temperature, 60rpm/min stirs 50min, obtains ointment-containing body;
D) coating of ointment-containing body: ointment-containing body prepared by step c) is coated on backing layer and protective layer, room temperature is placed 22h;
E) section;
F) packing.
embodiment 7 the present invention treat the Chinese herbs paste preparation (seven) of dysmenorrhea
1, basic composition
Backing layer: non-woven fabrics;
Protective layer: polyester film;
Ointment-containing body is comprised of following weight portion material: 10 parts of Chinese medical concretes, 6 parts of Kaolin, 12 parts of micropowder silica gels, 2 parts of glycerol, 6 parts of menthols, 20 parts of sodium alginates, 0.5 part of titanium dioxide;
Chinese medical concrete is made by the crude drug of following weight portion: 16 parts of Pollen Typhaes, 4 parts of Olibanums, 4 parts of Myrrhas, 5 parts of Sanguis Draxonis.
2, preparation method
A) get Pollen Typhae, Olibanum, Myrrha water and decoct 8 hours, then add Sanguis Draxonis to decoct 2 hours, filter post-heating and be concentrated into extractum;
B) preparation of substrate: add sodium alginate after Kaolin, micropowder silica gel are mixed with glycerol, menthol, stir;
C) preparation of ointment-containing body: the Chinese medical concrete that adds step a) to prepare in the substrate of preparing to step b), add titanium dioxide simultaneously, under room temperature, 70rpm/min stirs 50min, obtains ointment-containing body;
D) coating of ointment-containing body: ointment-containing body prepared by step c) is coated on backing layer and protective layer, room temperature is placed 22h;
E) section;
F) packing.
embodiment 8 the present invention treat the Chinese herbs paste preparation (eight) of dysmenorrhea
1, basic composition
Backing layer: non-woven fabrics;
Protective layer: polyester film;
Ointment-containing body is comprised of following weight portion material: 10 parts of Chinese medical concretes, 4 parts of Kaolin, 10 parts of micropowder silica gels, 2 parts of glycerol, 4 parts of menthols, 20 parts of sodium alginates, 0.5 part of titanium dioxide;
Chinese medical concrete is made by the crude drug of following weight portion: 14 parts of Pollen Typhaes, 4 parts of Olibanums, 4 parts of Myrrhas, 6 parts of Sanguis Draxonis.
2, preparation method
A) get Pollen Typhae, Olibanum, Myrrha water and decoct 8 hours, then add Sanguis Draxonis to decoct 3 hours, filter post-heating and be concentrated into extractum;
B) preparation of substrate: add sodium alginate after Kaolin, micropowder silica gel are mixed with glycerol, menthol, stir;
C) preparation of ointment-containing body: the Chinese medical concrete that adds step a) to prepare in the substrate of preparing to step b), add titanium dioxide simultaneously, under room temperature, 80rpm/min stirs 50min, obtains ointment-containing body;
D) coating of ointment-containing body: ointment-containing body prepared by step c) is coated on backing layer and protective layer, room temperature is placed 22h;
E) section;
F) packing.
comparative example 1
1, basic composition
Backing layer: non-woven fabrics;
Protective layer: polyester film;
Ointment-containing body is comprised of following weight portion material: 10 parts of Chinese medical concretes, 5 parts of Kaolin, 10 parts of micropowder silica gels, 3 parts of glycerol, 5 parts of Borneolum Syntheticums, 18 parts of sodium alginates, 1 part of titanium dioxide;
Chinese medical concrete is made by the crude drug of following weight portion: 15 parts of Pollen Typhaes, 5 parts of Olibanums, 5 parts of Myrrhas, 5 parts of Sanguis Draxonis.
2, preparation method
A) get Pollen Typhae, Olibanum, Myrrha water and decoct 6 hours, then add Sanguis Draxonis to decoct 3 hours, filter post-heating and be concentrated into extractum;
B) preparation of substrate: add sodium alginate after Kaolin, micropowder silica gel are mixed with glycerol, Borneolum Syntheticum, stir;
C) preparation of ointment-containing body: the Chinese medical concrete that adds step a) to prepare in the substrate of preparing to step b), add titanium dioxide simultaneously, under room temperature, 70rpm/min stirs 50min, obtains ointment-containing body;
D) coating of ointment-containing body: ointment-containing body prepared by step c) is coated on backing layer and protective layer, room temperature is placed 22h;
E) section;
F) packing.
comparative example 2
1, basic composition
Backing layer: non-woven fabrics;
Protective layer: polyester film;
Ointment-containing body is comprised of following weight portion material: 10 parts of Chinese medical concretes, 5 parts of Kaolin, 10 parts of micropowder silica gels, 3 parts of glycerol, 5 parts of menthols, 18 parts of sodium alginates, 1 part of titanium dioxide;
Chinese medical concrete is made by the crude drug of following weight portion: 30 parts of Pollen Tyjphae, 15 parts of Oletum Trogopterori (parched)s, 6 parts, Pericarpium Citri Reticulatae Viride, 15 parts of Rhizoma Sparganii, 15 parts of Rhizoma Curcumae, 12 parts of Fructus Crataegi, 3 parts of Olibanums, 3 parts of Myrrhas, 2 parts of Sanguis Draxonis powder.
2, preparation method
A) get Pollen Typhae, Olibanum, Myrrha water and decoct 6 hours, then add Sanguis Draxonis to decoct 3 hours, filter post-heating and be concentrated into extractum;
B) preparation of substrate: add sodium alginate after Kaolin, micropowder silica gel are mixed with glycerol, menthol, stir;
C) preparation of ointment-containing body: the Chinese medical concrete that adds step a) to prepare in the substrate of preparing to step b), add titanium dioxide simultaneously, under room temperature, 70rpm/min stirs 50min, obtains ointment-containing body;
D) coating of ointment-containing body: ointment-containing body prepared by step c) is coated on backing layer and protective layer, room temperature is placed 22h;
E) section;
F) packing.
comparative example 3
1, basic composition
Backing layer: non-woven fabrics;
Protective layer: polyester film;
Ointment-containing body is comprised of following weight portion material: 10 parts of Chinese medical concretes, 4 parts of Kaolin, 10 parts of micropowder silica gels, 2 parts of glycerol, 3.9 parts of menthols, 20 parts of sodium alginates, 0.5 part of titanium dioxide;
Chinese medical concrete is made by the crude drug of following weight portion: 14 parts of Pollen Typhaes, 4 parts of Olibanums, 4 parts of Myrrhas, 6 parts of Sanguis Draxonis.
2, preparation method
A) get Pollen Typhae, Olibanum, Myrrha water and decoct 8 hours, then add Sanguis Draxonis to decoct 3 hours, filter post-heating and be concentrated into extractum;
B) preparation of substrate: add sodium alginate after Kaolin, micropowder silica gel are mixed with glycerol, menthol, stir;
C) preparation of ointment-containing body: the Chinese medical concrete that adds step a) to prepare in the substrate of preparing to step b), add titanium dioxide simultaneously, under room temperature, 80rpm/min stirs 50min, obtains ointment-containing body;
D) coating of ointment-containing body: ointment-containing body prepared by step c) is coated on backing layer and protective layer, room temperature is placed 22h;
E) section;
F) packing.
embodiment 9 the present invention treat the effectiveness study of the Chinese herbs paste of dysmenorrhea
1, physical data
Diagnostic criteria is with reference to " the bureau of drug administration of disease of tcm Standardization of diagnosis and curative effect 》Ji Ministry of Health of the People's Republic of China " guideline of clinical investigations for the treatment of by Chinese herbs dysmenorrhea " of State Administration of Traditional Chinese Medicine's issue.Totally 250 examples, are the special outpatient clinic patient of the court, are divided at random 45 groups for the treatment of group, matched group one, matched group two, matched group three and matched groups, and each organizes 50 examples.Age 16-39 year, course of disease 1-10.Each organizes basic condition no significant difference, has comparability.
2, Therapeutic Method
Treatment group: use the patch of embodiment 1 preparation, SHENQUE acupoint, Guanyuan acupoint are chosen in acupuncture point, start to stick in premenstrual 1 week, sticks before sleeping, 1 paste/day, every adhesion medicine content 25.2g, application time: 8 hours summers, 12 hours other seasons.
Matched group one: use the patch of comparative example 1 preparation, SHENQUE acupoint, Guanyuan acupoint are chosen in acupuncture point, start to stick in premenstrual 1 week, sticks before sleeping, 1 paste/day, every adhesion medicine content 25.2g, application time: 8 hours summers, 12 hours other seasons.
Matched group two: use the patch of comparative example 2 preparations, SHENQUE acupoint, Guanyuan acupoint are chosen in acupuncture point, start to stick in premenstrual 1 week, sticks before sleeping, 1 paste/day, every adhesion medicine content 25.2g, application time: 8 hours summers, 12 hours other seasons.
Matched group three: use the patch of comparative example 3 preparations, SHENQUE acupoint, Guanyuan acupoint are chosen in acupuncture point, start to stick in premenstrual 1 week, sticks before sleeping, 1 paste/day, every adhesion medicine content 25.2g, application time: 8 hours summers, 12 hours other seasons.
Matched group four: from premenstrual 1 week of the moon within 1～2 day, take 5 parts of herb mixtures that decoct preparation of 15 parts of Pollen Typhaes, 5 parts of Olibanums, 5 parts of Myrrhas, Sanguis Draxonis, 3 doses/day, every dose of crude drug content 8.4g through row.
Treatment is added up curative effect after 3 months (course for the treatment of) continuously.
3, observational technique
Fluid rheology, urine PGE have a blood test
2, urine PGF
2a.Personnel are according to menstrual cycle for each group, and BBT situation was taken a blood sample and stayed urine premenstrual 1～2 day of the moon.Before and after treatment, detection time is consistent.Hemorheology adopts circumgyration to measure, and instrument R-80 type automatic blood viscosity apparatus is produced by Beijing Shi Di company.Urine PGE
2, urine PGF
2aadopt enzyme to exempt from method and measure, test kit is provided by U.S. Cayman Chemical company.All data with
± S represents, ranked data employing Ridit analysis, and remainder data is used t check.
4, criterion of therapeutical effect
With reference to " disease of tcm criterion of therapeutical effect ", judge (State Administration of Traditional Chinese Medicine. disease of tcm Standardization of diagnosis and curative effect [M]. Nanjing: publishing house of Nanjing University, 1994. 61～62.).
5, therapeutic outcome
The clinical efficacy of 5.1 each group treatments
The clinical efficacy of each group treatment is in Table 1.In table, data show, use the Chinese herbs paste treatment dysmenorrhea total effective rate of embodiment 1 preparation up to 98%, are significantly higher than matched group one to matched group four (P < 0.05).
Table 1 is respectively organized Clinical efficacy comparison
Note: * represents to compare P < 0.05 with treatment group.
Before and after 1.2 each group treatments, hemorheology changes
Before and after each group treatment, hemorheology situation of change is in Table 2.In table, data show, the whole blood contrast viscosity that treatment group, matched group three, matched group are 43 groups and plasma viscosity equal tool significantly decline (P < 0.05) before and after treatment.T verifies, and the whole blood contrast viscosity for the treatment of group and the fall of plasma viscosity are all significantly higher than matched group three and matched group four (P < 0.05).
Before and after each group treatment of table 2 hemorheology change relatively (
± S)
Note: * represents to compare P < 0.05 with treatment front and back.
Before and after 5.3 each group treatments, prostaglandin changes
Before and after each group treatment, prostaglandin situation of change is in Table 3.In table, data show, the PGE that treatment group, matched group three, matched group are 43 groups
2/ PGF
2aratio equal tool significantly rise (P < 0.05) before and after treatment.T verifies, the PGE for the treatment of group
2/ PGF
2aratio ascensional range is all significantly higher than matched group three and matched group four (P < 0.05).
Before and after each group treatment of table 3 prostaglandin change relatively (
± S)
Note: * represents to compare P < 0.05 with treatment front and back.
In sum, the present invention treats that matrix components, Chinese medical concrete raw material that the Chinese herbs paste of dysmenorrhea adopts form and proportioning is all very appropriate, percutaneous absorbs well, treatment dysmenorrhea effect is significantly better than oral administration route, is significantly better than take 30 parts of Pollen Tyjphae, 15 parts of Oletum Trogopterori (parched)s, 6 parts, Pericarpium Citri Reticulatae Viride, 15 parts of Rhizoma Sparganii, 15 parts of Rhizoma Curcumae, 12 parts of Fructus Crataegi, 3 parts of Olibanums, 3 parts of Myrrhas, 2 parts of patches of preparing as raw material of Sanguis Draxonis powder simultaneously.
The above is only the preferred embodiment of the present invention; it should be pointed out that for those skilled in the art, do not departing under the prerequisite of the inventive method; can also make some improvement and supplement, these improvement and supplement and also should be considered as protection scope of the present invention.
Claims (5)
1. a Chinese herbs paste for the treatment of dysmenorrhea, it is characterized in that, in the ointment-containing body of described Chinese herbs paste, each component and weight portion thereof are: Chinese medical concrete 8-10 part, Kaolin 4-6 part, micropowder silica gel 10-12 part, glycerol 2-4 part, menthol 4-6 part, sodium alginate 16-20 part, titanium dioxide 0.5-1 part, described Chinese medical concrete is made by the crude drug of following weight portion: Pollen Typhae 14-16 part, Olibanum 4-6 part, Myrrha 4-6 part, Sanguis Draxonis 5-6 part.
2. Chinese herbs paste according to claim 1, is characterized in that, described Chinese medical concrete is made by the crude drug of following weight portion: 15 parts of Pollen Typhaes, 5 parts of Olibanums, 5 parts of Myrrhas, 5 parts of Sanguis Draxonis.
3. Chinese herbs paste according to claim 1 and 2, it is characterized in that, in the ointment-containing body of described Chinese herbs paste, each component and weight portion thereof are: 10 parts of Chinese medical concretes, 5 parts of Kaolin, 10 parts of micropowder silica gels, 3 parts of glycerol, 5 parts of menthols, 18 parts of sodium alginates, 1 part of titanium dioxide.
4. the preparation method of the Chinese herbs paste described in claim 1 or 2, is characterized in that, comprises the following steps:
A) get Pollen Typhae, Olibanum, Myrrha water decoction 4-8 hour, then add Sanguis Draxonis to decoct 2-3 hour, filter post-heating and be concentrated into extractum;
B) add sodium alginate after Kaolin, micropowder silica gel are mixed with glycerol, menthol, stir;
C) Chinese medical concrete that adds step a) to prepare in the substrate of preparing to step b) adds titanium dioxide simultaneously, and under room temperature, 60-80rpm/min stirs, and obtains ointment-containing body;
D) ointment-containing body of being prepared by step c) is coated on backing layer and protective layer.
5. the application of the Chinese herbs paste described in claim 1 or 2 in the medicine of preparation treatment dysmenorrhea.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310480497.7A CN103520437B (en) | 2013-10-15 | 2013-10-15 | Chinese medicinal patch for treating dysmenorrhea, and preparation method and application thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310480497.7A CN103520437B (en) | 2013-10-15 | 2013-10-15 | Chinese medicinal patch for treating dysmenorrhea, and preparation method and application thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103520437A true CN103520437A (en) | 2014-01-22 |
| CN103520437B CN103520437B (en) | 2015-07-08 |
Family
ID=49923024
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201310480497.7A Active CN103520437B (en) | 2013-10-15 | 2013-10-15 | Chinese medicinal patch for treating dysmenorrhea, and preparation method and application thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN103520437B (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113082511A (en) * | 2021-03-05 | 2021-07-09 | 上海中医药大学附属岳阳中西医结合医院 | Wearing suit for relieving or treating dysmenorrhea |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1114206A (en) * | 1994-06-30 | 1996-01-03 | 彭多武 | Plaster for curing dysmenorrhea |
| CN1371739A (en) * | 2002-01-16 | 2002-10-02 | 深圳亿胜医药科技发展有限公司 | Supplemented myrrh dragon's blood tablet formula and preparation process thereof |
| CN101036677A (en) * | 2007-04-02 | 2007-09-19 | 昆明制药集团股份有限公司 | Compound notoginseng cataplasm |
-
2013
- 2013-10-15 CN CN201310480497.7A patent/CN103520437B/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1114206A (en) * | 1994-06-30 | 1996-01-03 | 彭多武 | Plaster for curing dysmenorrhea |
| CN1371739A (en) * | 2002-01-16 | 2002-10-02 | 深圳亿胜医药科技发展有限公司 | Supplemented myrrh dragon's blood tablet formula and preparation process thereof |
| CN101036677A (en) * | 2007-04-02 | 2007-09-19 | 昆明制药集团股份有限公司 | Compound notoginseng cataplasm |
Non-Patent Citations (2)
| Title |
|---|
| 丁秀贝: "没竭失笑散治疗膜样痛经80例", 《福建中医药》 * |
| 廖维: "加味没竭片治疗痛经93例观察", 《实用中医药杂志》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113082511A (en) * | 2021-03-05 | 2021-07-09 | 上海中医药大学附属岳阳中西医结合医院 | Wearing suit for relieving or treating dysmenorrhea |
| CN113082511B (en) * | 2021-03-05 | 2023-05-16 | 上海中医药大学附属岳阳中西医结合医院 | Wearing set for relieving or treating dysmenorrhea |
Also Published As
| Publication number | Publication date |
|---|---|
| CN103520437B (en) | 2015-07-08 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101391077B (en) | Preparation method of traditional Chinese medicine for treating chronic pelvic inflammatory disease | |
| CN100574797C (en) | A kind of plaster for the treatment of osteopathia | |
| CN103041173A (en) | Traditional Chinese medicine external preparation for curing dermatitis and eczema and preparing method thereof | |
| CN104189034A (en) | External patch with muscle and bone soothing effect and preparation method of external patch | |
| CN103611031B (en) | Be used for the treatment of the plaster of prostatic hyperplasia | |
| CN103251750B (en) | Externally applied medicinal oil for treating middle-aged and old-aged rheumatic diseases | |
| CN104940810A (en) | Traditional Chinese medicine composition for treating angina | |
| CN107184782A (en) | External medicine composition, preparation method and applications | |
| CN105582428A (en) | Transdermal patch for acupoint sticking therapy and preparation method thereof | |
| CN103071134B (en) | External preparation for treating rheumatic arthrodynia and traumatic pain and swelling and preparation method thereof | |
| CN104258304A (en) | Medicated wine for meridian unblocking, wind dispelling, collaterals activating and pain relieving | |
| CN106491787A (en) | A kind of Chinese mugwort cream moxibustion and preparation method thereof | |
| CN110731953A (en) | Traditional Chinese medicine compound cataplasm for treating qi-stagnation and blood stasis type cervical spondylosis and preparation method thereof | |
| CN103520437B (en) | Chinese medicinal patch for treating dysmenorrhea, and preparation method and application thereof | |
| CN105125708B (en) | A kind of pharmaceutical composition and preparation method thereof for rhinitis | |
| CN103845450A (en) | Application of hawthorns in preparing medicine for treating hyperuricemia, gout and renal insufficiency | |
| CN103893701B (en) | A kind of Chinese medicine composition alleviating patients suffering from postoperative pain and promote wound healing | |
| CN102961633B (en) | A kind of preparation for being used to treat postpartum rheumatism | |
| CN104800302A (en) | Externally applied plaster for treating thromboangiitis obliterans and preparation method | |
| CN102225125B (en) | Externally applied traditional Chinese medicine composite for treating joint pain caused by rheumatoid arthritis and preparation method thereof | |
| CN102743440A (en) | Traditional Chinese medicines for treating femoral head necrosis | |
| CN102283973A (en) | Traditional Chinese medicine plaster for treating benign tumor and reducing weight and preparation method thereof | |
| CN101642550B (en) | Plaster for treating chronic gastroenteritis and preparation method thereof | |
| CN105106786A (en) | Traditional Chinese medicine composition capable of dredging collaterals and relaxing muscles as well as preparation and production method of composition | |
| CN105055835A (en) | Traditional Chinese medicine composition used for treating female menopausal syndrome |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant |