CN103509102B - 野生型人生长激素突变体 - Google Patents
野生型人生长激素突变体 Download PDFInfo
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/61—Growth hormones [GH] (Somatotropin)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/70—Vectors or expression systems specially adapted for E. coli
Abstract
Description
A | B | C(EC50) | D | |
Wild Type | 0.38683 | 0.97738 | 62.41051 | 1.18484 |
Mutant1 | 0.3935 | 0.94341 | 30.59938 | 1.30384 |
Mutant2 | 0.40064 | 0.98 | 16.45342 | 1.23912 |
Mutant3 | 0.39798 | 0.99938 | 31.619 | 1.21946 |
Mutant4 | 0.37564 | 0.92167 | 31.58003 | 1.3006 |
Mutant5 | 0.37548 | 0.94143 | 8.08501 | 1.23807 |
Claims (1)
Priority Applications (1)
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CN201210198920.XA CN103509102B (zh) | 2012-06-15 | 2012-06-15 | 野生型人生长激素突变体 |
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CN201210198920.XA CN103509102B (zh) | 2012-06-15 | 2012-06-15 | 野生型人生长激素突变体 |
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CN103509102B true CN103509102B (zh) | 2015-07-22 |
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KR20180003677A (ko) * | 2016-06-30 | 2018-01-10 | 주식회사 크레아플래닛 | 인간 성장호르몬 변이 단백질 또는 이의 트랜스페린 융합 단백질을 유효성분으로 포함하는 약학적 조성물 |
CN112239760B (zh) * | 2020-09-18 | 2022-02-11 | 深圳科兴药业有限公司 | 高效表达重组hGH的重组工程菌及构建方法和应用 |
CN113880954A (zh) * | 2021-09-29 | 2022-01-04 | 江苏大学 | 一种重组人生长激素及其构建方法和应用 |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1269805A (zh) * | 1997-07-14 | 2000-10-11 | 博尔德生物技术公司 | 生长激素和相关蛋白的衍生物 |
WO2012010516A1 (en) * | 2010-07-22 | 2012-01-26 | Novo Nordisk Health Care Ag | Growth hormone conjugates |
-
2012
- 2012-06-15 CN CN201210198920.XA patent/CN103509102B/zh active Active
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1269805A (zh) * | 1997-07-14 | 2000-10-11 | 博尔德生物技术公司 | 生长激素和相关蛋白的衍生物 |
WO2012010516A1 (en) * | 2010-07-22 | 2012-01-26 | Novo Nordisk Health Care Ag | Growth hormone conjugates |
Non-Patent Citations (2)
Title |
---|
AAK69708;Roytrakul,S.et al.;《NCBI》;20030523;全文 * |
人生长激素突变体的制备及其对受体亲和力和生物活性的研究;李伟 等;《细胞生物学杂志》;20031231;全文 * |
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