CN103494967A

CN103494967A - Chinese medicinal preparation for treating tubercular meningitis of children

Info

Publication number: CN103494967A
Application number: CN201310428985.3A
Authority: CN
Inventors: 赵高伟
Original assignee: Individual
Current assignee: Individual
Priority date: 2013-09-09
Filing date: 2013-09-09
Publication date: 2014-01-08

Abstract

The invention discloses a Chinese medicinal preparation for treating tubercular meningitis of children. Traditional Chinese medicine theory shows that main pathogenesis of the tubercular meningitis of children comprises that are as follows: tuberculosis spreads into nutrient blood by taking advantage of a weak point, mental confusion is caused, yin and blood are deficient, blood can not nourish muscles and tendons and endogenous deficient wind is produced; t. Therefore, traditional Chinese medicines, namely baikal betony rhizome, companumoea root, tartarian buckwheat root and rhizome, autumn zephyrlily herb, alpine swertia, pungent litse fruit, lindera aggregate leaves, capitellate hedyotis herb, irkutsk anemone rhizome and lycopus, which have the effects of nourishing yin and clearing away heat, nourishing liver and relieving dizziness, warming yang and preventing steam counterflowfor resuscitation as well as inducing resuscitation by virtue of fragrance, are decocted into decoction with water, and; a clinical test carried out by a hospital (described in the specification) shows that the total effective rate is 97.4% and is obviously better than that of a control group.

Description

A kind of Chinese medicine preparation for the treatment of tuberculous meningitis in children

Technical field

The present invention relates to a kind of Chinese medicine composition, relate in particular to a kind of Chinese medicine preparation for the treatment of tuberculous meningitis in children.

Background technology

Tuberculous meningitis is because tulase is invaded pia mater encephali, arachnoidea and brain essence, the cerebrovascular pathological changes that the central nervous system causes.This disease is type the most serious in tuberculosis in children, and clinical manifestation is except general symptom lungy, often have symptoms such as severe headache, projectile vomiting, neck rigidity and disturbance of consciousness, cranial nerve palsy, paralysis.Can be divided into slurry type, basilar meningitis type, meningoencephalitis type and Tuberculous marrowbrain soft or hard meningitis type according to pathological change and clinical characters.Primary disease spring, morbidity was more, and age of onset mostly is 1-5 year.The applicant, through clinical trial for many years, utilizes the Children Treated with Chinese Traditional Drugs tuberculous meningitis to obtain curative effect preferably, and side effect is little.

Summary of the invention

The purpose of this invention is to provide a kind of Chinese medicine preparation for the treatment of tuberculous meningitis in children.The traditional Chinese medical science thinks that the main pathogenesis of primary disease is that the consumptive disease worm scurries into nutrient blood in an opponent's defence, the clear key of upper illiteracy, deficiency of YIN-blood, blood failing to nourish tendons, stirring-up of pathogenic wind in the interior resulting from deficiency.Sick position is mainly at the heart, liver, spleen.Characteristic of disease belongs to deficiency in origin and excess in superficiality more.Primary disease is critical syndrome, and deficiency of vital QI is it.The main principle for the treatment of primary disease is replenishing YIN and removing heat, and easing the affected liver relieves dizziness, high fever, infantile convulsions, epilepsy, etc., and warming YANG is rescued contrary, causing resuscitation with aromatic drugs.

The objective of the invention is to be achieved through the following technical solutions, the Chinese medicine preparation of this treatment tuberculous meningitis in children is made by the Chinese medicine of following weight portion: Rhizoma Stachydis 13-16 part, Radix Campanumoeae 8-15 part, Rhizoma Fagopyri Cymosi 15-20 part, Herba Zephyranthis Candidae 15-25 part, Herba Swertiae heteranthae 10-15 part, Fructus Litseae pungentis 5-10 part, Folium Linderae strychnifoliae 5-10 part, Lignum seu Radix Acronychiae 15-25 part, Rhizoma Anemones Altaicae 5-15 part, Rhizoma Lycopi Lucidi 5-15 part.

Preferably, 15 parts of Rhizoma Stachydiss, 12 parts of Radix Campanumoeaes, 18 parts of Rhizoma Fagopyri Cymosi, 20 parts of Herba Zephyranthis Candidaes, 12 parts of Herba Swertiae heteranthaes, 8 parts of Fructus Litseae pungentiss, 8 parts of Folium Linderae strychnifoliaes, 20 parts of Lignum seu Radix Acronychiaes, 10 parts of Rhizoma Anemones Altaicaes, 10 parts of Rhizoma Lycopi Lucidi.

Preparation method is made decoction by above-mentioned Chinese medicine decocting.

In side: Rhizoma Stachydis relieves inflammation or internal heat, suppressing the hyperactive liver, nourishing YIN; The Radix Campanumoeae nourishing YIN and moistening the lung, heat-clearing and toxic substances removing; The Rhizoma Fagopyri Cymosi heat-clearing and toxic substances removing, expelling wind and removing dampness; Herba Zephyranthis Candidae, Herba Swertiae heteranthae easing the affected liver relieve dizziness, high fever, infantile convulsions, epilepsy, etc.; Fructus Litseae pungentis, Folium Linderae strychnifoliae, Lignum seu Radix Acronychiae warming spleen and stomach for dispelling cold, promoting the circulation of QI to relieve pain, warming YANG are rescued contrary; The Rhizoma Anemones Altaicae eliminating phlegm of having one's ideas straightened out, the removing toxic substances of dispeling the wind; Rhizoma Lycopi Lucidi is had one's ideas straightened out and is invigorated blood circulation, the QI invigorating water that disappears.

Clinical data

1. this group of physical data infant 76 examples, be the out-patient, by table of random number, case is divided into to treatment group and each 38 examples of matched group at random.Male 20 examples for the treatment of group 38 example, female's 18 examples; Age is 1～6 years old, 3.1 years old mean age; 1～3 years old 25 example wherein, 4～6 years old 13 example.Show as heating person's 31 examples, 8 examples of having a headache, vomit 14 examples, 12 examples of twitching, and disorder of limb ' s activity 9 examples, neck rigidity 20 examples, loss of appetite 23 examples, become thin, night sweat 15 examples.Male 21 examples of matched group 38 example, female's 17 examples; Age is 1～6 years old, 3.2 years old mean age; 1～3 years old 24 example wherein, 4～6 years old 14 example.Show as heating person's 33 examples, 7 examples of having a headache, vomit 15 examples, 15 examples of twitching, and disorder of limb ' s activity 10 examples, neck rigidity 17 examples, loss of appetite 25 examples, become thin, night sweat 16 examples.Two groups of patients compare aspect sex, age, the state of an illness, and no significant difference (P>0.05), have comparability.

2. the vomiting of diagnostic criteria (1) unknown cause, headache and disposition change.(2) tuberculin test can be false negative.(3) cerebrospinal fluid: increased pressure, appearance transparent or be ground-glass-like, after standing 12～24 hours, can have the spider reticulation thin film to form, and plate coating checking, can find tulase.Total white blood cells (50～500) * 109/L, lymphocyte is main, and sugar and chloride content reduce, and protein quantification increases.(4) x-ray rabat: 85% knot brain infant has tuberculosis to change.(5) ophthalmofundoscopy: see the granular tubercle of choroid foxtail millet.

3. Therapeutic Method treatment group infant is taken Chinese medicine preparation of the present invention, take Rhizoma Stachydis 15g, Radix Campanumoeae 12g, Rhizoma Fagopyri Cymosi 18g, Herba Zephyranthis Candidae 20g, Herba Swertiae heteranthae 12g, Fructus Litseae pungentis 8g, Folium Linderae strychnifoliae 8g, Lignum seu Radix Acronychiae 20g, Rhizoma Anemones Altaicae 10g, Rhizoma Lycopi Lucidi 10g, decocting becomes decoction, every day potion, divide and sooner or later take for 2 times, each 10ml below 3 years old, 3～5 years old each 20m1,6 years old and above each 30ml.Matched group infant intramuscular injection streptomycin, consumption is 20-30mg/kg, every day 1 time; Oral isoniazid, every daily dose is 15-25mg/kg, every day 1 time.Two groups equal two weeks be a course for the treatment of, treat continuously 3 courses for the treatment of.

4. criterion of therapeutical effect is cured: symptom and sign disappears; Normal or the normal of CSF (cell<10/mm3, albumen<100mg/dl, sugar>36mg/dl, chloride>700mg/dl).Effectively: symptom, sign disappear; CSF is normal but have clear improvement not.Invalid: symptom, without alleviation, has the severe sequela, disability.

After two groups of therapeutic outcomes treatment 3 courses for the treatment of curative effect relatively, treatment group 38 examples, wherein cure 23 examples (60.5%); Effective 14 examples (36.9%), invalid 1 example (2.6%), total effective rate 97.4%; Matched group 38 examples, wherein cure 17 examples (44.7%); Effective 13 examples (34.2%), invalid 8 examples (21.1%), total effective rate 78.9%.Two groups relatively, and treatment group cure rate, total effective rate obviously are better than matched group, have comparability.P＜0.05。

The specific embodiment

Embodiment mono-: Rhizoma Stachydis 15g, Radix Campanumoeae 12g, Rhizoma Fagopyri Cymosi 18g, Herba Zephyranthis Candidae 20g, Herba Swertiae heteranthae 12g, Fructus Litseae pungentis 8g, Folium Linderae strychnifoliae 8g, Lignum seu Radix Acronychiae 20g, Rhizoma Anemones Altaicae 10g, Rhizoma Lycopi Lucidi 10g, make decoction by above-mentioned Chinese medicine decocting.

Embodiment bis-: Rhizoma Stachydis 16g, Radix Campanumoeae 15g, Rhizoma Fagopyri Cymosi 20g, Herba Zephyranthis Candidae 25g, Herba Swertiae heteranthae 15g, Fructus Litseae pungentis 5g, Folium Linderae strychnifoliae 10g, Lignum seu Radix Acronychiae 15g, Rhizoma Anemones Altaicae 15g, Rhizoma Lycopi Lucidi 5g, make decoction by above-mentioned Chinese medicine decocting.

Embodiment tri-: Rhizoma Stachydis 13g, Radix Campanumoeae 8g, Rhizoma Fagopyri Cymosi 15g, Herba Zephyranthis Candidae 15g, Herba Swertiae heteranthae 10g, Fructus Litseae pungentis 10g, Folium Linderae strychnifoliae 5g, Lignum seu Radix Acronychiae 25g, Rhizoma Anemones Altaicae 5g, Rhizoma Lycopi Lucidi 15g, make decoction by above-mentioned Chinese medicine decocting.

Claims

1. a Chinese medicine preparation for the treatment of tuberculous meningitis in children, is characterized in that this Chinese medicine preparation made by the Chinese medicine of following weight portion: Rhizoma Stachydis 13-16 part, Radix Campanumoeae 8-15 part, Rhizoma Fagopyri Cymosi 15-20 part, Herba Zephyranthis Candidae 15-25 part, Herba Swertiae heteranthae 10-15 part, Fructus Litseae pungentis 5-10 part, Folium Linderae strychnifoliae 5-10 part, Lignum seu Radix Acronychiae 15-25 part, Rhizoma Anemones Altaicae 5-15 part, Rhizoma Lycopi Lucidi 5-15 part.

2. a kind of Chinese medicine preparation for the treatment of tuberculous meningitis in children according to claim 1, is characterized in that this Chinese medicine preparation made by the Chinese medicine of following weight portion: 15 parts of Rhizoma Stachydiss, 12 parts of Radix Campanumoeaes, 18 parts of Rhizoma Fagopyri Cymosi, 20 parts of Herba Zephyranthis Candidaes, 12 parts of Herba Swertiae heteranthaes, 8 parts of Fructus Litseae pungentiss, 8 parts of Folium Linderae strychnifoliaes, 20 parts of Lignum seu Radix Acronychiaes, 10 parts of Rhizoma Anemones Altaicaes, 10 parts of Rhizoma Lycopi Lucidi.