CN103494959B - Drug for treating high blood pressure - Google Patents
Drug for treating high blood pressure Download PDFInfo
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- CN103494959B CN103494959B CN201310480608.4A CN201310480608A CN103494959B CN 103494959 B CN103494959 B CN 103494959B CN 201310480608 A CN201310480608 A CN 201310480608A CN 103494959 B CN103494959 B CN 103494959B
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Abstract
The invention discloses a drug for treating high blood pressure and relates to Chinese traditional patent medicine. The drug is prepared from, according to a formula, by weight, 1-2 parts of smelly jasmine leaves, 1-2 parts of persimmon leaves and 10-20 parts of black Chinese olive leaves. The dried smelly jasmine leaves, the dried persimmon leaves and the dried black Chinese olive leaves are blended and smashed to be prepared into an agent, or capsules, or packed into packages through tea-brewing paper. The drug for treating the high blood pressure has the advantages of good curative effect with a total effective rate of treating the high blood pressure reaching to 97.5% and an efficiency show rate reaching to 86.9%, rapidness in effect and immediate effect for symptoms of brain swelling and fatigue, safeness and no toxic side effects for normal use, and easiness in obtaining raw materials and preparing and applying.
Description
Technical field
The present invention relates to Chinese patent medicine, espespecially one treats hypertensive medicine.
Background technology
Hypertension raises with systolic arterial pressure under quiescent condition and diastolic pressure to exceed the disease that normal range is symptom, is a kind of systemic disease being attended by the functional or organic change of heart, blood vessel, brain and kidney and other organs.
The Chinese medicine of China is a treasure-house of extensive knowledge and profound scholarship, contains huge usefulness, Chinese medicine or Chinese patent drugs for treatment hypertension no exception.
Chinese patent discloses health-care blood pressure lowering food (publication number CN 102028219A), and its formula is (by weight) Folium Crataegi 1 ~ 5 part, Folium clausenae lansii 0.1 ~ 2 part, 0.1 ~ 2 part, Fructus Citri tangerinae leaf, Folium Canarii Pimelae 5 ~ 20 parts.This health-care blood pressure lowering food has started beginning Folium Canarii Pimelae being used for blood pressure lowering, and the combination of their specific deal has the effect of blood pressure lowering.But its formula requires further improvement, curative effect needs to improve further, and using method needs the selection that more can meet patient.
Summary of the invention
The present invention is intended to the kind enriching blood pressure lowering Chinese patent medicine, improves the effect of blood pressure lowering Chinese patent medicine, provides one to treat hypertensive medicine.Its formula material is easy to get, and makes easy, can be made into multiple dosage form, and curative effect is given prominence to.
In order to realize above-mentioned task, the present invention is a kind of, and to treat the technical scheme of hypertensive medicine as follows.
One treats hypertensive medicine, and formula is by weight, 1 ~ 2 part, Radix clerodendri fragrantis (Radix Clerodendri Philippini) leaf, Folium Kaki 1 ~ 2 part, Folium Canarii Pimelae 10 ~ 20 parts; By the dry Radix clerodendri fragrantis (Radix Clerodendri Philippini) leaf of described deal, dry Folium Kaki and dry Folium Canarii Pimelae co-grinding, make tablet or capsule or make with paper bag of making tea and wrap.
Described Radix clerodendri fragrantis (Radix Clerodendri Philippini) leaf in we is the leaf of Radix clerodendri fragrantis (Radix Clerodendri Philippini), and Radix clerodendri fragrantis (Radix Clerodendri Philippini) belongs to semishrub plant.See army rear service portion, Guangzhou " conventional Chinese herbal medicine handbook " the 374th page (People's Health Publisher, in March, 1970 publishes), a main expelling wind and activating blood circulation in we, detumescence, the effect of blood pressure lowering.
Described Folium Kaki in we is the leaf of fruit tree Fructus Kaki.Edit " Chinese herbal medicine identification and application " (middle volume) the 154th page (the Guangdong People's Press, in December, 2010 publish) see Liu Jizhu, in we main rise sending down the abnormal ascending QI only oh, arrhythmia and sedation.
Modern pharmacology research shows, Folium Kaki has pharmacological action widely, comprise the multiple efficacies such as vasodilation (vessel softening), blood fat-reducing blood pressure-decreasing, hemostasis (" chemical composition of Folium Kaki, pharmacological action, clinical practice and exploitation " food and fermentation industries 2005 VOL 31 NO7, Lin Jiaofen etc.).
Described Folium Canarii Pimelae in we is the leaf of Fructus Canarii Pimelae fruit tree." southern medicinal plants illustrated handbook " the 122nd page (publishing house of University Of Shantou, in JIUYUE, 2004 is published) is edited see Wang Yusheng, Cai Yuewen.Mainly in we play hemostasis, heat-clearing and toxic substances removing, reducing swelling and alleviating pain, reduce phlegm, effect of diuretic.
Modern study experiment proves, Folium Canarii Pimelae water extract is to Hypertensive Rats having remarkable hypotensive effect (" Folium Canarii Pimelae water extract to stress Hypertensive Rats have the research of remarkable hypotensive effect ", Tianjin medical science, 2007,35(8): 587 ~ 590).Point out in " Folium Canarii Pimelae water extract is to Isolated Rat blood vessel direct effect experimentation " (Guangdong medical science, November the 29th in 2008 volume o. 11th): 1. Folium Canarii Pimelae has has diastole effect to vascular smooth muscle, and has certain dose relation; 2. to high potassium bring out vascular ring shrink tension force there is booster action.
Hypertensive is a very complicated process, relate to many aspects such as nerve, body fluid, inner skin cell function, genetic defect, be summed up three approach and cause elevation of the blood pressure: 1. peripheral blood vessel increases (resistance vessel contraction)---cause based on the hypertension of diastolic pressure rising; 2. cardiac output increases (increased heart rate, myocardial contraction strengthens)---and causing systolic pressure to raise is main hypertension; 3. the increase of blood vessel amount or blood viscosity increase.
The traditional Chinese medical science thinks that hypertension is depressed emotion, be enraged troubled thoughts so that depression of liver-QI, fire-transformation impairment of YIN; Or intemperance of taking food, hungry full inappropriate, taste are injured, the turbid interior life of expectorant; Or old asthenia, Liver and kidney imbalance of YIN and YANG etc.The basic principle of Traditional Chinese Medical on Treating Hypertension: conditioning viscera function, recovers equilibrium between yin and yang.In above-mentioned three kinds of leaves, Radix clerodendri fragrantis (Radix Clerodendri Philippini) leaf plays expelling wind and activating blood circulation, detumescence, blood pressure lowering.Folium Kaki plays blood fat reducing, reduces blood viscosity, reduces hypertensive effect.Folium Canarii Pimelae plays significant hypotensive activity, the heating that simultaneously cures cold, cough due to lung-heat, reduces phlegm.These three kinds of cool collocation of leaf temperature, hot or cold and cool body constitution is all suitable.We from the promoting flow of QI and blood that reduces phlegm, remove unnecessary blood fat and cholesterol is started with, and to reduce blood viscosity for handgrip, the effective ingredient of three kinds of leaves is coordinated mutually, complements each other, and realizes reducing hypertensive effect with its specific composition combination and specific deal combination thereof.
The present invention has outstanding feature: one is good effect, and treatment high blood pressure disease total effective rate reaches 97.5%, and obvious effective rate reaches 86.9%; Two is instant effects, especially to dizzy or tired symptom, can at once take effect; Three is safety, and positive common medicine, has no side effect.Four is that raw material is easy to get, and makes easy.
Detailed description of the invention
Below, the specific embodiment of the present invention is introduced.
One, embodiment
Embodiment 1
One treats hypertensive medicine, and formula is by weight, 1 part, Radix clerodendri fragrantis (Radix Clerodendri Philippini) leaf, Folium Kaki 1 part, Folium Canarii Pimelae 10 parts; By the dry Radix clerodendri fragrantis (Radix Clerodendri Philippini) leaf of described deal, dry Folium Kaki and dry Folium Canarii Pimelae co-grinding, make tablet or capsule or make with paper bag of making tea and wrap.
Embodiment 2
One treats hypertensive medicine, and formula is by weight, 1 part, Radix clerodendri fragrantis (Radix Clerodendri Philippini) leaf, Folium Kaki 1 part, Folium Canarii Pimelae 15 parts; By the dry Radix clerodendri fragrantis (Radix Clerodendri Philippini) leaf of described deal, dry Folium Kaki and dry Folium Canarii Pimelae co-grinding, make tablet or capsule or make with paper bag of making tea and wrap.
Embodiment 3
One treats hypertensive medicine, and formula is by weight, 1 part, Radix clerodendri fragrantis (Radix Clerodendri Philippini) leaf, Folium Kaki 1 part, Folium Canarii Pimelae 20 parts; By the dry Radix clerodendri fragrantis (Radix Clerodendri Philippini) leaf of described deal, dry Folium Kaki and dry Folium Canarii Pimelae co-grinding, make tablet or capsule or make with paper bag of making tea and wrap.
Embodiment 4
One treats hypertensive medicine, and formula is by weight, 2 parts, Radix clerodendri fragrantis (Radix Clerodendri Philippini) leaf, Folium Kaki 2 parts, Folium Canarii Pimelae 15 parts; By the dry Radix clerodendri fragrantis (Radix Clerodendri Philippini) leaf of described deal, dry Folium Kaki and dry Folium Canarii Pimelae co-grinding, make tablet or capsule or make with paper bag of making tea and wrap.
Two, clinical observation test
(1), clinical treatment
Case selection: since 2012, select 269 routine hyperpietics carry out clinical observation test, all with the diagnostic criteria of higher medical institution teaching material for foundation, be divided into three case groups:
1, tablet case group is taken, 73 examples;
2, capsule case group is taken, 81 examples;
3, group is taken in the mode of making tea, 115 examples.
(2), using method
1, take tablet case group, the tablet of oral medicine, three times on the one, each 5 grams, then reduce in right amount depending on change of illness state.From every day three times, after blood pressure is normal, decrement is to every twice-daily, then decrement is to once a day, to the next day maintenance dose to keep blood pressure normal.
2, take capsule case group, the capsule of oral medicine, three times on the one, each 5 grams, then reduce in right amount depending on change of illness state.From every day three times, after blood pressure is normal, decrement is to every twice-daily, then decrement is to once a day, to the next day maintenance dose to keep blood pressure normal.
The mode of 3, making tea with the boiled water that boils takes group, makes tea oral with this medicated bag, three times on the one, and each 1 parcel (5 grams) boils boiled water bubble, and connect punching 4 ~ 5 and to steep time, often bubble time washes about 150 milliliters, water open, leaches tea and drinks, then reduce in right amount depending on change of illness state.From every day three times, after blood pressure is normal, decrement is to every twice-daily, then decrement is to once a day, to the next day maintenance dose to keep blood pressure normal.
4, observe change, before taking medicine and treatments period, check blood pressure, body temperature, pulse and heartbeat function, treatments period checks once every day.
5, points for attention:
1) if the hypertension caused because of heart, nephropathy, this disease of Ying Xianzhi coordinates blood pressure lowering again.
2) most hyperpietic is relevant with Bad Eating Habit, answers light diet in daily life, the few fat of the few sugar of few salt, few smoking is drunk less and is spilt, dish dredged by polyphagia fruit, and do not eat pluck, fat and decoct, explode, fire food, Broiled Dish is wherein as roasted chicken duck goose etc.
3) contraindication in pregnancy.
4) take after the meal, avoid untoward reaction.
(3), observation of curative effect
1, criterion of therapeutical effect (three groups of cases carry out a standard):
Effective---second day that takes medicine first, dizzy or tired symptom obviously alleviated, and within the 15th day, took blood pressure normal.
Effectively---second day that takes medicine first, dizzy or tired symptom alleviated, the 15th staggering amount blood pressure drops.
Invalid---clinical symptoms without improving [by inquiry with analyze, do not guard against mouth by points for attention requirement with patient, still eat pluck, fat and decoct, explode, to fire food etc. relevant].
2, observed result
(4), toxic and side effects test
Take in the mode of making tea of this medicine, toxicity test is carried out to white mice.Get every day 15 grams steep that the tea (about 750 milliliters) of 5 times is cool freeze with the boiled water that boils after to throw something and feed 10 white mice, within continuous 30 days, observe, white mice reaction without exception, none is dead.
(5), model case introduction
Zhong Tianzhao, 48 years old now, in February, 2012 rose, and has a hunch fatigue, nose heave, blurred vision, sleep before 9 every night, perpendicular day 6 a lot of beds, always have inadequate sensation of sleeping.Through taking blood pressure, being 200/112mmHg, is severe hypertension.Take in the mode of making tea of this medicine, morning, noon and afternoon every day are each after the meal, and once each parcel (5 ɡ) boiled water that boils brews, and connect punching 4 ~ 5 and steep secondary, often bubble washes about 150 milliliters, water open, leaches tea and drinks.Second day original symptom of drinking this medicated tea obviously alleviates, the 5th day 165/92 mmHg that takes blood pressure, the 10th day 152/85 mmHg that takes blood pressure, the 15th day 142/80 mmHg that takes blood pressure, normal blood pressure.Within 16th day, rising to the 36th day was second course for the treatment of, and sooner or later after the meal respectively once each parcel (5 ɡ), took blood pressure, remained between 138 ~ 140/77 ~ 80 mmHg for every 5 days every day.3rd course for the treatment of from the 37th day to half a year, once a day, each parcel (5 ɡ).Change into more every other day once after half a year, each parcel (5 ɡ).Adhere to having drunk more than a year, blood pressure remains on normal range.
Liu Shiguang, 70 years old now, because hypertensive stroke is hospitalized for treatment before 2 years, taking Western medicine after leaving hospital had half a year, blood pressure or higher, and blood pressure is 175/106mmHg.Take morning, noon and afternoon every day early stage after the meal respectively once in the mode of making tea of this medicine, each parcel (5 ɡ) boiled water that boils brews to lightly seasoned, leaches tea and drinks, and within the 5th day, taking blood pressure is 163/98 mmHg, the 10th day
amountblood pressure is 14,2/8 6 mmHg, normal, and change every day after 10 days into sooner or later after the meal respectively once, each parcel (5 ɡ), took blood pressure every 5 days and substantially remain between 140 ~ 142/78 ~ 82 mmHg, belonged to the normal arterial pressure that old people is higher.Drunk again more than 20 day, changed into afterwards once a day, drunk half a year, changed into often every other day once after half a year, have more than a year so far, blood pressure is all in range of normal value.
Pan Mengying, 65 years old now, the year before because hypertension often has headache and fatigue symptom, often arrive community clinic garter and get it filled, blood pressure is still difficult to recover normal value, heavy time light during symptom.Blood pressure 170/102 mmHg before taking this medicine also has headache, fatigue symptom.Easily how first time took this Drug Capsule after one hour, original symptom obviously alleviates.Get this Drug Capsule and overcome use by every day 3 times, each 5, do not beat garter and do not eat other depressor, after 15 days, blood pressure recovers normal value.Thereafter, medication is decrement progressively, and existing maintenance dose every other day once (5 grams).Blood pressure is normal over one year: 139 ~ 140/79 ~ 81 mmHg.
(6), untoward reaction
When taking in the mode of making tea of this medicine, if on an empty stomach drink, saliva is light to have one or two people to feel, has the sensation of regurgitation, therefore drinks after the meal and be advisable.
(7), brief summary
1, from a kind of clinical observation for the treatment of hypertensive medicine of this 269 routine hyperpietic being taken to the present invention's release, this medicine has therapeutical effect to high blood pressure disease, and total effective rate reaches 97.5%, and wherein obvious effective rate reaches 86.9%.
2, in Clinical practice, in the body temperature of patient, blood pressure measurement and cardiac auscultation, do not find obvious adverse reaction, this medicine no side effects can be described.
Claims (5)
1. treat a hypertensive medicine, it is characterized in that, formula is by weight: 1 ~ 2 part, Radix clerodendri fragrantis (Radix Clerodendri Philippini) leaf, Folium Kaki 1 ~ 2 part, Folium Canarii Pimelae 10 ~ 20 parts; By the dry Radix clerodendri fragrantis (Radix Clerodendri Philippini) leaf of described deal, dry Folium Kaki and dry Folium Canarii Pimelae co-grinding, make tablet or capsule or make with paper bag of making tea and wrap.
2. one according to claim 1 treats hypertensive medicine, it is characterized in that, formula is by weight: 1 part, Radix clerodendri fragrantis (Radix Clerodendri Philippini) leaf, Folium Kaki 1 part, Folium Canarii Pimelae 10 parts; By the dry Radix clerodendri fragrantis (Radix Clerodendri Philippini) leaf of described deal, dry Folium Kaki and dry Folium Canarii Pimelae co-grinding, make tablet or capsule or make with paper bag of making tea and wrap.
3. one according to claim 1 treats hypertensive medicine, it is characterized in that, formula is by weight: 1 part, Radix clerodendri fragrantis (Radix Clerodendri Philippini) leaf, Folium Kaki 1 part, Folium Canarii Pimelae 15 parts; By the dry Radix clerodendri fragrantis (Radix Clerodendri Philippini) leaf of described deal, dry Folium Kaki and dry Folium Canarii Pimelae co-grinding, make tablet or capsule or make with paper bag of making tea and wrap.
4. one according to claim 1 treats hypertensive medicine, it is characterized in that, formula is by weight: 2 parts, Radix clerodendri fragrantis (Radix Clerodendri Philippini) leaf, Folium Kaki 2 parts, Folium Canarii Pimelae 15 parts; By the dry Radix clerodendri fragrantis (Radix Clerodendri Philippini) leaf of described deal, dry Folium Kaki and dry Folium Canarii Pimelae co-grinding, make tablet or capsule or make with paper bag of making tea and wrap.
5., according to the hypertensive medicine of claim 1 one kind treatment, it is characterized in that, formula is by weight: 1 part, Radix clerodendri fragrantis (Radix Clerodendri Philippini) leaf, Folium Kaki 1 part, Folium Canarii Pimelae 20 parts; By the dry Radix clerodendri fragrantis (Radix Clerodendri Philippini) leaf of described deal, dry Folium Kaki and dry Folium Canarii Pimelae co-grinding, make tablet or capsule or make with paper bag of making tea and wrap.
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| CN201310480608.4A CN103494959B (en) | 2013-10-15 | 2013-10-15 | Drug for treating high blood pressure |
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