CN109463607A - A kind of food digesting stomach fortifying, food and medicament dual-purpose solid beverage product of promoting the circulation of qi defaecation and preparation method thereof - Google Patents
A kind of food digesting stomach fortifying, food and medicament dual-purpose solid beverage product of promoting the circulation of qi defaecation and preparation method thereof Download PDFInfo
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Classifications
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
- A23L2/385—Concentrates of non-alcoholic beverages
- A23L2/39—Dry compositions
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
- A23L2/02—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation containing fruit or vegetable juices
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
- A23L2/02—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation containing fruit or vegetable juices
- A23L2/04—Extraction of juices
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K36/42—Cucurbitaceae (Cucumber family)
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- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
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- A61K36/752—Citrus, e.g. lime, orange or lemon
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- A61P1/10—Laxatives
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
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- Alternative & Traditional Medicine (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Nutrition Science (AREA)
- Polymers & Plastics (AREA)
- Food Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
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- Medicines Containing Plant Substances (AREA)
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Abstract
The present invention relates to technical field of Chinese medicine, and in particular to a kind of food digesting stomach fortifying, food and medicament dual-purpose solid beverage product of promoting the circulation of qi defaecation and preparation method thereof.The effective component of the product is prepared from the following materials: hawthorn, fig, orange peel, Siraitia grosvenorii, jujube, Radix Glycyrrhizae.Using hawthorn, fig as monarch drug in a prescription；Orange peel, Siraitia grosvenorii are ministerial drug；Jujube, Radix Glycyrrhizae are adjuvant, have food digesting stomach fortifying, promoting the circulation of qi defaecation effect.It can be used for that postpartum is high in fat, high-protein diet intake is excessive, move very few, fullness in chest and hypochondrium, distending pain in abdomen occur, the symptoms such as constipation caused by food of receiving is reduced or hemorrhoid and postpartum uterus restore bad.The present invention selects pressure difference solvent fluid broken wall+continuous gradient molecule sieving repeatedly+low temperature to be concentrated and dried the orientation abstraction technique combination such as crystallization+on-line near infrared spectroscopy analysis, the harmful and invalid components such as removing heavy metals, agriculture are residual, change is residual, impurity are gone to greatest extent, and are efficiently kept completely separate extraction active constituent.
Description
Technical field
The present invention relates to technical field of Chinese medicine, and in particular to a kind of food digesting stomach fortifying, promoting the circulation of qi defaecation food and medicament dual-purpose solid
Beverage product and preparation method thereof.
Background technique
Overexertion when puerpera is because of childbirth, postpartum bed is excessive, and puerperium excessive sweating or stress reaction are excessive, ridge
Column and the micro- arthrochalasis of pelvis shift, and usually can all make abdominal muscle and pelvic diaphragm muscle relaxation, shrink inability, and abdominal pressure disappears, and abdomen is dirty
Internal organs postpartum resets slowly, to keep enterocinesia slow, big benefit of traditional postpartum in addition is high in fat, high-protein diet is excessive, and causes just
It is secret, and then uterus recovery is also influenced, and will affect mood and lactation, cause a series of postpartum problems.Clinically it is generally necessary to
Symptomatic treatment is carried out using oral drugs, mainly for decorporation just medication, lacks whole nourish and improves；In addition woman's postpartum health
Lack of control causes to be easy to appear the common postpartum disease such as the deficiency of vital energy, deficiency of blood, also has the special physiologicals period such as woman menstruation also can be because
The problems such as endocrine, is led to the symptoms such as constipation, indigestion and mood change, generally also may require that alleviate these symptoms and adopts
Symptomatic treatment is carried out with oral drugs.
Although also occur on the market now it is some for women special physiological period or postpartum fullness in chest and hypochondrium, it is swollen in abdomen
Bitterly, the oral drugs for the symptoms such as food of receiving is reduced, and defecation is unsmooth, these product one side effects are relatively simple, such as main performance
Decorporation is just or the abdominal distension that disappears acts on, and there are certain side effects, and there are also extract oral products for diseases such as postpartum deficient qi and bloods
Shape, less effective work slower, lack the Orally taken product with multiple comprehensive health-care effect；On the other hand, existing traditional Chinese medicine mouth
Take product exist formula is excessively complicated, chemical assistant content is higher, technology content is lower, quality matte, active constituent are indefinite,
Impurity composition is higher, sanitary standard is lower, security quality causes anxiety, and cost is also higher equal obvious insufficient.Especially most of tastes
Scent experience is poor, it is difficult to adhere to taking.Urgently there is upgraded product to meet the city of mainstream consumer group's rapid growth of new generation
Field just needs.
Summary of the invention
In order to overcome prior art defect, the object of the present invention is to provide a kind of food digesting stomach fortifyings, the food medicine two of promoting the circulation of qi defaecation
With solid beverage product, postpartum is high in fat, high-protein diet intake is excessive to alleviate, and moves very few, fullness in chest and hypochondrium occurs, swollen in abdomen
Bitterly, it receives and eats the symptoms such as reduction or hemorrhoid and postpartum uterus and the bad caused constipation of pelvic cavity internal organs organ position recovery
Person can be used as the safe postpartum oral administration solid beverage product of pure natural active in women postpartum and special physiological period.
Further, the present invention, which also resides in, provides the food and medicament dual-purpose solid beverage product of a kind of food digesting stomach fortifying, promoting the circulation of qi defaecation
Preparation method, can be improved the extraction of raw material pharmaceutically active ingredient and the quality of application efficiency and product, and product meets compared with Gao Wei
Raw standard, can reach organic food-grade quality, the safe drink of women for being more in line with the special physiological phase just needs.
In order to achieve the goal above, the technical scheme adopted by the invention is that:
A kind of food digesting stomach fortifying, promoting the circulation of qi defaecation food and medicament dual-purpose solid beverage product, effective component by following parts by weight original
Material is prepared: 5~30 parts of hawthorn, 5~30 parts of fig, 5~25 parts of orange peel, 5~30 parts of Siraitia grosvenorii, 5~30 parts of jujube, sweet
5~20 parts of grass.
Preferably, above-mentioned food digesting stomach fortifying, promoting the circulation of qi defaecation food and medicament dual-purpose solid beverage product, effective component is by following heavy
Amount number raw material be prepared: 10~25 parts of hawthorn, 10~25 parts of fig, 10~20 parts of orange peel, 10~25 parts of Siraitia grosvenorii,
10~25 parts of jujube, 5~10 parts of Radix Glycyrrhizae.
It is further preferred that the food and medicament dual-purpose solid beverage product of above-mentioned food digesting stomach fortifying, promoting the circulation of qi defaecation, effective component by
The raw material of following parts by weight is prepared: 20 parts of hawthorn, 20 parts of fig, 13 parts of orange peel, 20 parts of Siraitia grosvenorii, 20 parts of jujube,
7 parts of Radix Glycyrrhizae.
It is both medicinal material and the genuine food and medicament dual-purpose food materials of food that above-mentioned raw materials medicine, which is selected, safe to the human body harmless.
Above-mentioned food digesting stomach fortifying, promoting the circulation of qi defaecation food and medicament dual-purpose solid beverage product preparation method, including following operation step
It is rapid:
S1. raw material crushes: after weighing hawthorn, fig, orange peel, jujube, Siraitia grosvenorii, Radix Glycyrrhizae crushing in parts by weight, must crush
Material；
S2. impregnate: by the comminuting matter in S1, adding volumetric concentration is that 20 ~ 40% ethyl alcohol is impregnated；
S3. wall-breaking abstraction: using volumetric concentration be 20 ~ 40% ethyl alcohol as solvent, step S2 is impregnated into material and passes through pressure difference solvent stream
The continuous dynamic extraction of body, obtains extract liquor；
S4. it is centrifugated: absolute extract liquid will be obtained after extract liquor centrifugation, filtering in S3；
S5. molecular sieve micro-filtration: the absolute extract liquid of step S4 is subjected to molecular sieve filtration, obtains target extract liquor；
S6. it is concentrated: after the target extract liquor of step S5 is successively recycled ethyl alcohol, and carrying out reverse osmosis membrane concentration and reduced pressure,
Thick medicinal extract is obtained, it is dry after thick medicinal extract is crystallized, material is made to get the solid beverage product.
Optionally, crush in step S1 is specially to crush hawthorn, fig, orange peel, jujube, Siraitia grosvenorii, Radix Glycyrrhizae cleaning
To 30 ~ 300 mesh.
Optionally, impregnating in step S2 is specially 10 ~ 30min of ethyl alcohol immersion that 15 ~ 30 times of volumes are added.
Optionally, in step S3 the continuous dynamic extraction of pressure difference solvent fluid low pressure be 3MPa ~ 5MPa, high pressure be 18MPa ~
20MPa, Extracting temperature are 25 ~ 65 DEG C, and extraction time is 20 ~ 60min.
Optionally, molecular sieve filtration is successively to be sieved through filter by many-level molecule in step S5, wherein filtering molecular sieves for the first time
Filtration MW having a size of 10000nm ~ 100000nm, the filtration MW of quadratic component sieve is having a size of 50nm ~ 800nm, end
The filtration MW of secondary molecular sieve is having a size of 10nm~100nm.
Optionally, it carries out reverse osmosis membrane in step S6 first to target extract liquor and is concentrated into Baume degrees to be 2 ~ 15, then exist
Vacuum degree -0.09MPa carries out being concentrated under reduced pressure into Baume degrees 20 ~ 35 under the conditions of 45 ~ 55 DEG C, obtains thick medicinal extract.
Above-mentioned gynaecology's postpartum oral administration solid beverage product is whole during the preparation process to use on-line near infrared spectroscopy analysis skill
Art realizes the online timely, Visible human plan to product quality.
Above-mentioned solid beverage product when in use, with appropriate warm boiled water, took in by, high-protein diet high in fat to postpartum
It is more, it moves very few, fullness in chest and hypochondrium occurs, distending pain in abdomen is big caused by food of receiving is reduced or hemorrhoid and postpartum uterus restore bad
The symptoms such as constipation knot can play rapid recovery and therapeutic effect.
Food digesting stomach fortifying of the present invention, promoting the circulation of qi defaecation food and medicament dual-purpose solid beverage product, using hawthorn, fig as monarch drug in a prescription, nothing
Flowers and fruits are sweet in flavor, warm, and stomach invigorating digestion-aid effect is gentle, hawthorn acid, sweet, warm, two medicines share both can flavoring, can also make appetizing effect,
Gram cutting down effect will not be too strong, and because hawthorn disappears, carnivorous, gram food effect is more violent, so two medicine compatibilities play mutual balanced action, makes spleen
Stomach must help, without excessively undermining the gas of temper.Orange peel, Siraitia grosvenorii ministerial drug, dried orange peel promoting the circulation of qi invigorating the spleen, Siraitia grosvenorii can clearing lung-heat heat and
Logical stool.Two medicines and monarch drug in a prescription are with that can reinforce the help digestion stagnant, abdominal distension that disappears effect and alleviation abdominal pain pain, and fig is later to control in addition
Hemorrhoid and be it is civil commonly used, then hemorrhoid aggravate for constipation, Siraitia grosvenorii and fig compatibility, not only defaecation but also the hemorrhoid that disappear, this is orthodox
Doctor is the excellent compatibility seldom noticed, the side of holding person is excavated obtained by the wild civil experience in township.Jujube, Radix Glycyrrhizae are adjuvant,
Air making-up and spleen enlivening, makes that full side is aid digestion, the stagnant defaecation that disappears is more gentle, and ingredient is based on fruit article, after prescription based on sour-sweet, makes
Patient is more easily accepted by.Party's promoting the circulation of qi helps digestion, tonneau stool, in order to be unable to cut down too, so addition jujube, Radix Glycyrrhizae replenish qi to invigorate the spleen,
Play balanced action.Full side reaches food digesting stomach fortifying, promoting the circulation of qi defaecation effect.It can be used for that postpartum is high in fat, high-protein diet intake is excessive,
It moves very few, fullness in chest and hypochondrium occurs, distending pain in abdomen, stool caused by food of receiving is reduced or hemorrhoid and postpartum uterus restore bad
Constipated equal symptoms.
Compared with prior art, the invention has the following advantages and beneficial effects:
1, product is made with hawthorn, fig, orange peel, Siraitia grosvenorii, jujube, glycyrrhizic liuwei drug in the formula of innovative product of the present invention
Effective component, have food digesting stomach fortifying, promoting the circulation of qi defaecation effect.It can be used for that postpartum is high in fat, high-protein diet intake is excessive, be moved through
It is few, there is fullness in chest and hypochondrium, distending pain in abdomen, it is big caused by food of receiving is reduced or hemorrhoid and the displacement of postpartum pelvic cavity internal organs restore bad
The symptoms such as constipation knot can provide the multifunctional solid beverage system of a kind of more safety and fashion the postpartum special physiological phase for women
Product；
2, the present invention select the continuous cleaning of dynamic crush+repeatedly solvent fluid broken wall+continuous gradient molecule sieving+low temperature concentration it is dry
Constipation crystalline substance+on-line near infrared spectroscopy analysis etc. orients abstraction technique combination, by hawthorn, fig, orange peel, jujube, Siraitia grosvenorii, sweet
Grass is crushed using cleaning, with the continuous dynamic broken wall of pressure difference solvent fluid and molecular orientation screening extraction, can be removed to greatest extent
The harmful components such as heavy metal, agriculture is residual, change is residual, bacterium, impurity, and efficiently, completely by contained effective component separating and extracting；And this
Kind extracting method is suitble to the manufacture of 4.0 wisdom of high-volume quantity-produced, and overall process is without heating, and non-exhaust emission, industrial water can
It is recycled and recovery processing, waste residue full price utilizes, comply fully with green manufacturing standard, wisdom manufacture with higher can operate
Property and ecological environment cost performance；
3, pressure difference solvent fluid extraction stage of the present invention, vacuum concentration stage and drying phase under vacuum, temperature control 35-65 DEG C
Within, whole low temperature is more advantageous to compared with traditional water boiling and extraction technique and guarantees active principle activity；
4, present invention extraction material belongs to high loose crystalline solid, and dissolubility is good, cold and hot all molten, and does not add any excipient, resistive connection
Agent, the auxiliary materials such as flavoring agent, preservative, the scope of application is wider, safer；
5, the Chinese medicine in inventive formulation is food and medicament dual-purpose food materials, safe and non-toxic, can be used for a long time, and women special physiological is suitable for
The health care in postpartum phase.
6, product of the present invention ingredient is small-molecule substance, is easily directly absorbed by mucous membranes such as oral cavity and throat and oesophaguses,
The significant biopotency of comparison is shown, so as to comparatively fast play nutrient energy supplement and balanced action.
7, product of the present invention can be completely dissolved within 3 seconds, as clear as crystal, without any precipitating and impurity, be retained
There are the color, smell and taste gas of former 80% or more plant material, good mouthfeel, consumer is more willing to accept.
Specific embodiment
The technical scheme of the invention is described in detail through specific implementation examples.
It is both medicinal material and the genuine food and medicament dual-purpose food materials of food that bulk pharmaceutical chemicals in following embodiments, which are selected, is pacified to human body
Completely without evil.
Embodiment 1
A kind of food digesting stomach fortifying, promoting the circulation of qi defaecation food and medicament dual-purpose solid beverage product, effective component by following parts by weight original
Material is prepared: 20 parts of hawthorn, 20 parts of fig, 13 parts of orange peel, 20 parts of Siraitia grosvenorii, 20 parts of jujube, 7 parts of Radix Glycyrrhizae.
Preparation method, including following operating procedure:
S1. raw material crushes: weigh hawthorn in parts by weight, fig, orange peel, jujube, Siraitia grosvenorii, Radix Glycyrrhizae cleaning be crushed to 60 ~
150 mesh, obtain comminuting matter；
S2. impregnate: by the comminuting matter in S1, the ethyl alcohol that the volumetric concentration that 20 times of amounts are added is 20% impregnates 30 minutes；
S3. wall-breaking abstraction: for the ethyl alcohol for being 30% using volumetric concentration as solvent, material is 4MPa in low pressure after step S2 is impregnated, high
Pressure is 20MPa, and Extracting temperature is to obtain extract liquor the continuous Dynamic Extraction of pressure difference solvent fluid 45 minutes under the conditions of 35 ~ 50 DEG C；
S4. it is centrifugated: absolute extract liquid will be obtained after extract liquor centrifugation, filtering in S3；
S5. molecular sieve micro-filtration: by the filtration MW of the absolute extract liquid of step S4 filtering molecular sieve for the first time having a size of 10000nm
~ 100000nm, the filtration MW of quadratic component sieve having a size of 50nm ~ 800nm, take measurements by the filtering molecular of last molecular sieve
For 10nm~100nm, target extract liquor is obtained；
S6. it is concentrated: the target extract liquor of step S5 successively being carried out reverse osmosis membrane to be concentrated into Baume degrees being 2, obtains primary extract；So
It is afterwards -0.09MPa in vacuum degree by primary extract, carries out being concentrated under reduced pressure into Baume degrees 25 under the conditions of 50 DEG C, obtain thick medicinal extract；It will be thick
It is dry after medicinal extract is crystallized, material is made to get the solid beverage product.
Embodiment 2
A kind of food digesting stomach fortifying, promoting the circulation of qi defaecation food and medicament dual-purpose solid beverage product, effective component by following parts by weight original
Material is prepared: 30 parts of hawthorn, 5 parts of fig, 25 parts of orange peel, 25 parts of Siraitia grosvenorii, 5 parts of jujube, 5 parts of Radix Glycyrrhizae.
The preparation method of above-mentioned food digesting stomach fortifying, promoting the circulation of qi defaecation solid beverage product, with embodiment 1.
Embodiment 3
A kind of food digesting stomach fortifying, promoting the circulation of qi defaecation solid beverage product, effective component are prepared by following raw material in parts by weight:
5 parts of hawthorn, 30 parts of fig, 5 parts of orange peel, 30 parts of Siraitia grosvenorii, 10 parts of jujube, 20 parts of Radix Glycyrrhizae.
The preparation method of above-mentioned food digesting stomach fortifying, promoting the circulation of qi defaecation solid beverage product, with embodiment 1.
Embodiment 4
A kind of food digesting stomach fortifying, promoting the circulation of qi defaecation food and medicament dual-purpose solid beverage product, effective component by following parts by weight original
Material is prepared: 10 parts of hawthorn, 25 parts of fig, 10 parts of orange peel, 5 parts of Siraitia grosvenorii, 30 parts of jujube, 10 parts of Radix Glycyrrhizae.
The preparation method of above-mentioned food digesting stomach fortifying, promoting the circulation of qi defaecation solid beverage product, including following operating procedure:
S1. raw material crushes: weigh hawthorn in parts by weight, fig, orange peel, jujube, Siraitia grosvenorii, Radix Glycyrrhizae cleaning be crushed to 30 ~
150 mesh, obtain comminuting matter；
S2. impregnate: by the comminuting matter in S1, the ethyl alcohol that the volumetric concentration that 30 times of amounts are added is 40% impregnates 10 minutes；
S3. wall-breaking abstraction: for the ethyl alcohol for being 20% using volumetric concentration as solvent, material is 5MPa in low pressure after step S2 is impregnated, high
Pressure is 19MPa, and Extracting temperature is to obtain extract liquor the continuous Dynamic Extraction of pressure difference solvent fluid 60 minutes under the conditions of 25 ~ 40 DEG C；
S4. it is centrifugated: absolute extract liquid will be obtained after extract liquor centrifugation, filtering in S3；
S5. molecular sieve micro-filtration: by the filtration MW of the absolute extract liquid of step S4 filtering molecular sieve for the first time having a size of 10000nm
~ 100000nm, the filtration MW of quadratic component sieve having a size of 50nm ~ 800nm, take measurements by the filtering molecular of last molecular sieve
For 10nm~100nm, target extract liquor is obtained；
S6. it is concentrated: after the target extract liquor of step S5 is successively recycled ethyl alcohol, successively carrying out reverse osmosis membrane and be concentrated into Baume degrees and be
15, obtain primary extract；Then it is -0.09MPa in vacuum degree by primary extract, carries out being concentrated under reduced pressure into Baume degrees under the conditions of 55 DEG C
35, obtain thick medicinal extract；It is dry after thick medicinal extract is crystallized, material is made to get the solid beverage product.
Embodiment 5
A kind of food digesting stomach fortifying, promoting the circulation of qi defaecation food and medicament dual-purpose solid beverage product, effective component by following parts by weight original
Material is prepared: 25 parts of hawthorn, 10 parts of fig, 20 parts of orange peel, 10 parts of Siraitia grosvenorii, 25 parts of jujube, 10 parts of Radix Glycyrrhizae.
Above-mentioned food digesting stomach fortifying, promoting the circulation of qi defaecation food and medicament dual-purpose solid beverage product preparation method, including following operation step
It is rapid:
S1. raw material crushes: weigh hawthorn in parts by weight, fig, orange peel, jujube, Siraitia grosvenorii, Radix Glycyrrhizae cleaning be crushed to 100 ~
300 mesh, obtain comminuting matter；
S2. impregnate: by the comminuting matter in S1, the ethyl alcohol that the volumetric concentration that 15 times of amounts are added is 30% impregnates 20 minutes；
S3. wall-breaking abstraction: for the ethyl alcohol for being 40% using volumetric concentration as solvent, material is 3MPa in low pressure after step S2 is impregnated, high
Pressure is 18MPa, and Extracting temperature is to obtain extract liquor the continuous Dynamic Extraction of pressure difference solvent fluid 20 minutes under the conditions of 45 ~ 65 DEG C；
S4. it is centrifugated: absolute extract liquid will be obtained after extract liquor centrifugation, filtering in S3；
S5. molecular sieve micro-filtration: by the filtration MW of the absolute extract liquid of step S4 filtering molecular sieve for the first time having a size of 10000nm
~ 100000nm, the filtration MW of quadratic component sieve having a size of 50nm ~ 800nm, take measurements by the filtering molecular of last molecular sieve
For 10nm~100nm, target extract liquor is obtained；
S6. it is concentrated: after the target extract liquor of step S5 is recycled ethyl alcohol, successively carrying out reverse osmosis membrane and be concentrated into Baume degrees to be 10,
Obtain primary extract；Then it is -0.09MPa in vacuum degree by primary extract, carries out being concentrated under reduced pressure into Baume degrees 20 under the conditions of 45 DEG C,
Obtain thick medicinal extract；It is dry after thick medicinal extract is crystallized, material is made to get the solid beverage product.
Comparative example 1
This comparative example, effective component are prepared by following raw material in parts by weight: 50 parts of hawthorn, 50 parts of fig.Specifically
The preparation method is the same as that of Example 1.
This comparative example difference from example 1 is that, keep bulk pharmaceutical chemicals total weight number it is constant, and monarch drug in a prescription use
In the case where measuring constant rate, ministerial drug and adjuvant are saved.Drug effect verification result shows that the comparative example is to production compared to embodiment 1
After there is fullness in chest and hypochondrium, distending pain in abdomen, the diseases such as constipation caused by food of receiving is reduced or hemorrhoid and postpartum uterus restore bad
Shape, without apparent treatment and alleviation effect.
Comparative example 2
This comparative example, effective component are prepared by following raw material in parts by weight: 27 parts of hawthorn, 27 parts of fig, orange peel
19 parts, 27 parts of Siraitia grosvenorii.It is specific that the preparation method is the same as that of Example 1.
This comparative example difference from example 1 is that, keep bulk pharmaceutical chemicals total weight number it is constant, monarch drug in a prescription, minister
Survival dose constant rate, saves adjuvant.Drug effect verification result shows that, compared to embodiment 1, which chest side of body occurs to postpartum
Turgor, distending pain in abdomen, the symptoms such as constipation caused by food of receiving is reduced or hemorrhoid and postpartum uterus restore bad, without bright
Aobvious treatment and alleviation effect.
Comparative example 3
This comparative example, effective component are prepared by following raw material in parts by weight: 30 parts of hawthorn, 13 parts of orange peel, Siraitia grosvenorii
30 parts, 20 parts of jujube, 7 parts of Radix Glycyrrhizae.It is specific that the preparation method is the same as that of Example 1.
This comparative example difference from example 1 is that, keep bulk pharmaceutical chemicals total weight number it is constant, monarch drug in a prescription hawthorn
Ratio increases, and saves fig, and adjuvant is constant, and drug effect verification result shows that, compared to embodiment 1, which goes out postpartum
Existing fullness in chest and hypochondrium, distending pain in abdomen, the reduced symptom of food of receiving without apparent treatment and alleviates effect, to postpartum hemorrhoid and postpartum
The treatment of the symptoms such as constipation caused by palace restores bad and alleviation effect are decreased obviously.
Comparative example 4
This comparative example, effective component are prepared by following raw material in parts by weight: 20 parts of radish seed, 20 parts of fig, tangerine
13 parts of skin, 20 parts of Siraitia grosvenorii, 20 parts of jujube, 7 parts of Radix Glycyrrhizae；It is specific that the preparation method is the same as that of Example 1.
This comparative example difference from example 1 is that, keep bulk pharmaceutical chemicals total weight number it is constant, use and mountain
The similar radish seed of short, bristly hair or beard action and efficacy replaces hawthorn, and drug effect verification result shows that, compared to embodiment 1, which goes out postpartum
Existing fullness in chest and hypochondrium, distending pain in abdomen, the symptoms such as constipation caused by food of receiving is reduced or hemorrhoid and postpartum uterus restore bad
Treatment and alleviation effect are decreased obviously.
Comparative example 5
This comparative example, effective component are prepared by following raw material in parts by weight: 20 parts of hawthorn, 20 parts of fig, fingered citron
13 parts, 20 parts of Siraitia grosvenorii, 20 parts of jujube, 7 parts of Radix Glycyrrhizae；It is specific that the preparation method is the same as that of Example 1.
This comparative example difference from example 1 is that, orange peel is replaced using the fingered citron similar with orange peel action and efficacy,
Drug effect verification result shows that, compared to embodiment 1, which fullness in chest and hypochondrium, distending pain in abdomen occurs to postpartum, and food of receiving is reduced, or
The treatment of the symptoms such as constipation caused by hemorrhoid and postpartum uterus restore bad and alleviation effect are decreased obviously.
Comparative example 6
This comparative example, effective component are prepared by following raw material in parts by weight: 20 parts of hawthorn, 20 parts of fig, orange peel
13 parts, 20 parts of lily, 20 parts of jujube, 7 parts of Radix Glycyrrhizae.
This comparative example difference from example 1 is that, using lily similar to Siraitia grosvenorii effect replace Siraitia grosvenorii, medicine
Effect card the result shows that, compare embodiment 1, the symptoms such as which fullness in chest and hypochondrium occurs to postpartum, distending pain in abdomen, and food of receiving is reduced
Treatment alleviate effect and be decreased obviously, there are hemorrhoid to postpartum and the symptoms such as constipation caused by postpartum uterus restores bad
Without apparent treatment and alleviate effect.
Comparative example 7
This comparative example, effective component are prepared by following raw material in parts by weight: 36 parts of hawthorn, 4 parts of fig, orange peel 13
Part, 20 parts of Siraitia grosvenorii, 20 parts of jujube, 7 parts of Radix Glycyrrhizae.It is specific that the preparation method is the same as that of Example 1.
Compared with Example 1 compared with: the preparation method of comparative example does not change, but the proportion being formulated changes, wherein monarch drug in a prescription hawthorn
The effect of ratio increases, and fig ratio reduces, promoting the circulation of qi defaecation reduces, and full side's food digesting stomach fortifying, promoting the circulation of qi defaecation effect is just not so good as original
Ratio is comprehensive and works well, and proportion of this formula is whole not in the invention patent ratio range, influences to be formulated effect, reduction
Therapeutic effect.
Comparative example 8
This comparative example, effective component are prepared by following raw material in parts by weight: 20 parts of hawthorn, 20 parts of fig, orange peel 4
Part, 36 parts of Siraitia grosvenorii, 20 parts of jujube, 7 parts of Radix Glycyrrhizae.It is specific that the preparation method is the same as that of Example 1.
Compared with Example 1 compared with: the preparation method of comparative example does not change, but the proportion being formulated changes, wherein ministerial drug arhat
Fruit ratio increases, and the ratio of orange peel reduces, and full side's food digesting stomach fortifying, promoting the circulation of qi defaecation effect is just not so good as former ratio comprehensively and effect is good
Good, the proportion of this formula is whole not in the invention patent ratio range, influences to be formulated effect, reduces therapeutic effect.
Comparative example 9
This comparative example, effective component are prepared by following raw material in parts by weight: 27 parts of hawthorn, 32 parts of fig, orange peel
13 parts, 20 parts of Siraitia grosvenorii, 4 parts of jujube, 4 parts of Radix Glycyrrhizae.
Compared with embodiment: the preparation method of comparative example does not change, but the proportion being formulated changes, and wherein adjuvant is big
Jujube, Radix Glycyrrhizae ratio reduce, and monarch drug in a prescription fig ratio increases.Full side's food digesting stomach fortifying, it is comprehensive that promoting the circulation of qi defaecation effect is just not so good as former ratio
With work well, proportion of this formula is whole not in the invention patent ratio range, influences to be formulated effect, reduces treatment effect
Fruit.
By the drug effect verification result of above-mentioned comparative example and embodiment 1 it is found that ministerial drug or adjuvant when formula omit, formula
The type of middle replacement bulk pharmaceutical chemicals is the bulk pharmaceutical chemicals with same drug effect, changes the bulk pharmaceutical chemicals usage ratio of formula, can be made entire
The effect of formula, changes, so that effect declines, or cannot play more comprehensively comprehensive action and efficacy, or even will appear
The effects of can only whet the appetite effect, cannot play and uterine contraction is remarkably reinforced, and improve puerperal constipation, it can be seen that the invention
Property selection hawthorn, fig, orange peel, jujube, Siraitia grosvenorii, Radix Glycyrrhizae compound made of effective component, using each bulk pharmaceutical chemicals from
The particularity of body makes to can be good at playing collaboration compatibility effect, raising and abundant curative effect of medication between each other.
Test example
Clinical effectiveness verification test:
Clinical case is chosen: choosing clinical diagnosis postpartum, eating accumulation postpartum and abdominal distension occurs and receives trouble of the poor person's age at 25 ~ 40 years old
Person 120, it is randomly divided into 10 groups；Postpartum constipation person's age is chosen at patient 120 of 25 ~ 40 years old, is randomly divided into 10 groups；
Every group of patient is corresponding respectively using the product of embodiment 1, comparative example 1 ~ 9；
Application method: each 2g, with about 150ml warm boiled water, 3 times a day；
Use the course for the treatment of: 7 days
Curative effect determinate standard:
Effective: symptom disappears after taking 7 days or integral reduces >=70%；
Effective: symptom improves after taking 7 days, and integral reduces >=30%, < 70%；
Invalid: symptom reduces < 30% without alleviation or integral after taking 7 days.
The effective percentage and inefficiency of every group of patient are counted, wherein efficient is (effective number+effective number)/total case
Number；Inefficiency is invalid number/total case number, as a result as shown in table 1 below:
Table 1
Embodiment 4, clinical effectiveness and the embodiment 1 of 5 product of embodiment are basic is equal, the comprehensive effect of embodiment 2 and embodiment 3
Fruit is not so good as embodiment 1, but comprehensive function effect is better than comparative example 1 ~ 9.
Observe and record each product to puerperal abdominal flatulence receive difference effect, the results showed that 1 > comparative example of embodiment, 6 > comparative example
8 > comparative example, 9 > comparative example, 5 > comparative example, 7 > comparative example, 4 > comparative example, 2 > comparative example, 1 > comparative example 3.
Each product is observed and recorded to the effect of postpartum constipation, the results showed that 1 > comparative example of embodiment, 4 > comparative example
9 > comparative example, 5 > comparative example, 8 > comparative example, 3 > comparative example, 2 > comparative example, 7 > comparative example, 1 > comparative example 6.
By the result of the clinical effectiveness verification test of above-mentioned test example it is found that 1 product of embodiment has food digesting stomach fortifying, promoting the circulation of qi
Defaecation effect.It can be used for that postpartum is high in fat, high-protein diet intake is excessive, move very few, fullness in chest and hypochondrium occur, distending pain in abdomen is received
Food is reduced or the symptoms such as hemorrhoid and the bad caused constipation of postpartum uterus recovery generate significant treatment and alleviation work
With.The usage ratio for changing inventive formulation bulk pharmaceutical chemicals, changes the monarch compatibility of formula, or even replace with by bulk pharmaceutical chemicals
Other bulk pharmaceutical chemicals with same drug effect can all influence entire effect of product.The present invention is suitably former by the selection of innovation
Expect medicine, using the specific pharmacological property of bulk pharmaceutical chemicals, it is made to cooperate with compatibility between each other, while simplifying formula, so that preparation
Product has multi-efficiency, and the safety that can be used as women postpartum and special physiological period takes orally gynaecology's postpartum oral administration solid beverage
Product.
Finally, it should be noted that the above embodiments are merely illustrative of the technical solutions of the present invention, rather than its limitations；Although
Present invention has been described in detail with reference to the aforementioned embodiments, those skilled in the art should understand that: it still may be used
To modify the technical solutions described in the foregoing embodiments or equivalent replacement of some of the technical features；
And these are modified or replaceed, technical solution of various embodiments of the present invention that it does not separate the essence of the corresponding technical solution spirit and
Range.
Claims (9)
1. the food and medicament dual-purpose solid beverage product of a kind of food digesting stomach fortifying, promoting the circulation of qi defaecation, which is characterized in that its effective component is by following
The raw material of parts by weight is prepared: 5~30 parts of hawthorn, 5~30 parts of fig, 5~25 parts of orange peel, 5~30 parts of Siraitia grosvenorii, big
5~30 parts of jujube, 5~20 parts of Radix Glycyrrhizae.
2. the food and medicament dual-purpose solid beverage product of food digesting stomach fortifying as described in claim 1, promoting the circulation of qi defaecation, which is characterized in that its
Effective component is prepared by following raw material in parts by weight: 10~25 parts of hawthorn, 10~25 parts of fig, orange peel 10~20
Part, 10~25 parts of Siraitia grosvenorii, 10~25 parts of jujube, 5~10 parts of Radix Glycyrrhizae.
3. the food and medicament dual-purpose solid beverage product of food digesting stomach fortifying as described in claim 1, promoting the circulation of qi defaecation, which is characterized in that its
Effective component is prepared by following raw material in parts by weight: 20 parts of hawthorn, 20 parts of fig, 13 parts of orange peel, 20 parts of Siraitia grosvenorii,
20 parts of jujube, 7 parts of Radix Glycyrrhizae.
4. it is a kind of as the described in any item food digesting stomach fortifyings of claim 1 ~ 3, promoting the circulation of qi defaecation food and medicament dual-purpose solid beverage product
Preparation method, which is characterized in that including following operating procedure:
S1. raw material crushes: weighing hawthorn, fig, orange peel, jujube, Siraitia grosvenorii, Radix Glycyrrhizae in parts by weight and crushes, obtains 60-200
Mesh comminuting matter；
S2. it impregnates: by the comminuting matter in S1, the ethyl alcohol that volumetric concentration is 20 ~ 40% is added and is impregnated；
S3. wall-breaking abstraction: using volumetric concentration be 20 ~ 40% ethyl alcohol as solvent, step S2 is impregnated into material and passes through pressure difference solvent stream
The continuous dynamic extraction of body, obtains extract liquor；
S4. it is centrifugated: absolute extract liquid will be obtained after extract liquor centrifugation, filtering in S3；
S5. molecular sieve micro-filtration: the absolute extract liquid of step S4 is subjected to molecular sieve filtration, obtains target extract liquor；
S6. it is concentrated: after the target extract liquor of step S5 is recycled ethyl alcohol, successively carrying out reverse osmosis membrane concentration and reduced pressure, obtain
Thick medicinal extract, it is dry after thick medicinal extract is crystallized, material is made to get the solid beverage product.
5. the preparation method of food digesting stomach fortifying as claimed in claim 4, promoting the circulation of qi defaecation solid beverage product, which is characterized in that step
The low pressure of the continuous dynamic extraction of pressure difference solvent fluid is 3MPa ~ 5MPa in rapid S3, and high pressure is 18MPa ~ 20MPa, and Extracting temperature is
25 ~ 65 DEG C, extraction time is 20 ~ 60min.
6. the preparation method of food digesting stomach fortifying as claimed in claim 4, promoting the circulation of qi defaecation solid beverage product, which is characterized in that step
In rapid S5 molecular sieve filtration be successively be sieved through filter by many-level molecule, wherein for the first time the filtration MW of filtering molecular sieve having a size of
10000nm ~ 100000nm, the filtration MW of quadratic component sieve is having a size of 50nm ~ 800nm, the filtering molecular of last molecular sieve
It takes measurements as 10nm~100nm.
7. the preparation method of food digesting stomach fortifying as claimed in claim 4, promoting the circulation of qi defaecation solid beverage product, which is characterized in that step
Ethyl alcohol recycling is carried out first to target extract liquor in rapid S6, and being concentrated into Baume degrees by reverse osmosis membrane is 2 ~ 15, then true
Reciprocal of duty cycle -0.09MPa carries out being concentrated under reduced pressure into Baume degrees 20 ~ 35 under the conditions of 45 ~ 55 DEG C, obtains thick medicinal extract.
8. the preparation method of food digesting stomach fortifying as claimed in claim 4, promoting the circulation of qi defaecation solid beverage product, which is characterized in that step
It is impregnated in rapid S2 for the ethyl alcohol of 15 ~ 30 times of volumes of material is added and impregnates 10 ~ 30min.
9. the preparation method of food digesting stomach fortifying as claimed in claim 4, promoting the circulation of qi defaecation solid beverage product, which is characterized in that step
It is crushed in rapid S1 as 30 ~ 300 mesh will be crushed to after hawthorn, fig, orange peel, jujube, Siraitia grosvenorii, Radix Glycyrrhizae cleaning.
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Application publication date: 20190315 |