CN103494906A - Chewable tablet for livestock, as well as preparation method and application of tablet - Google Patents
Chewable tablet for livestock, as well as preparation method and application of tablet Download PDFInfo
- Publication number
- CN103494906A CN103494906A CN201310473216.5A CN201310473216A CN103494906A CN 103494906 A CN103494906 A CN 103494906A CN 201310473216 A CN201310473216 A CN 201310473216A CN 103494906 A CN103494906 A CN 103494906A
- Authority
- CN
- China
- Prior art keywords
- parts
- chewable tablet
- radix glycyrrhizae
- preparation
- calcium carbonate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Abstract
The invention provides a chewable tablet for livestock. The chewable tablet is prepared from following raw materials and auxiliary materials in parts by weight: 60-100 parts of crataegus pinnatifida bunge, 12-20 parts of glycyrrhiza uralensis, 25-35 parts of calcium carbonate, 40-50 parts of lactose, 5-15 parts of starch and a suitable amount of a lubricating agent. The chewable tablet is good in external properties, is proper in mouth feel and rigidity, has the effects of invigorating the stomach and helping to digest, supplementing calcium and increasing the weight, can obviously accelerate the growth of the livestock and has a high clinical value.
Description
Technical field
The present invention relates to a kind of chewable tablet for animals and its production and use.
Background technology
The Fructus Crataegi Gly cyrrhiza tea, be comprised of Fructus Crataegi 30 grams, Radix Glycyrrhizae 6 grams, is the good recipe of promoting digestion and invigorating the stomach, blood circulation promoting and blood stasis dispelling.Wherein, Fructus Crataegi since ancient times, just becomes the good medicine of spleen benefiting and stimulating the appetite, relieving dyspepsia, phlegm reduction of blood circulation promoting.Fructus Crataegi does medicinal with fruit, slightly warm in nature, and sour in the mouth is sweet, enters spleen, stomach, Liver Channel, and the function of promoting digestion and invigorating the stomach, activating blood circulation to dissipate blood stasis, convergence dysentery relieving is arranged.Fructus Crataegi is rich in multiple organic acid, can keep the vitamin C in Fructus Crataegi, even in the situation that heating is also unlikely destroyed.Radix Glycyrrhizae has invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, the effect of coordinating the actions of various ingredients in a prescription.For weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, gastral cavity abdomen, the anxious pain of extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strong." not Lu " record: " warming the middle warmer and descending qi, hinder dirty cough, the warming the meridian arteries and veins, and sharp vim and vigour, separate hundred poison of drug." " Japan hanako materia medica " record: " the peace soul is determined soul.Mend five kinds of strain and seven kinds of impairment, all are deficient, palpitation with fear, unhappy, forgetful.Also there is antiinflammatory, antiviral, and the effects such as protecting liver and detoxication and enhancing immunologic function.Radix Glycyrrhizae can promote stomach mucus to form and secretion, extends the epithelial cell life-span, and anti-inflammatory activity is arranged, and is usually used in the treatment of chronic ulcer and duodenal ulcer; The flavone of Radix Glycyrrhizae has antiinflammatory, spasmolytic and antiacid effect.
Calcium carbonate is calsium supplement commonly used in current veterinary drug, in current most veterinary drugs, all has Fructus Crataegi Radix Glycyrrhizae and calcium carbonate compound recipe, thus the effect that reaches invigorating the stomach and promoting digestion simultaneously and replenish the calcium.
Chewable tablet, be chew in oral cavity or suck after clothes dissolve sheet the tablet of swallowing, and through chewing, rear surface is long-pending to increase tablet, can promote medicine dissolving and absorption in vivo; Taking convenience, can swallow, chew containing sucking or with taking after aqueous dispersion.If Fructus Crataegi Gly cyrrhiza tea and calcium carbonate compound recipe can be prepared into to chewable tablet, will be convenient to the utilization of medicine.
Summary of the invention
The object of the present invention is to provide a kind of chewable tablet for animals and its production and use.
The invention provides a kind of chewable tablet for animals, it is that supplementary material by following weight proportion is prepared from:
60～100 parts of Fructus Crataegis, 12～20 parts, Radix Glycyrrhizae, 25～35 parts of calcium carbonate, 40～50 parts of lactose, 5～15 parts of starch, lubricant are appropriate.
Further, it is that supplementary material by following weight proportion is prepared from:
80 parts of Fructus Crataegis, 16 parts, Radix Glycyrrhizae, 30 parts of calcium carbonate, 45 parts of lactose, 10 parts of starch, lubricant are appropriate.
Further, described lubricant is selected from magnesium stearate.
Preferably, the consumption of described magnesium stearate is 0.5～2 part.
The present invention also provides the preparation method of above-mentioned chewable tablet, and it comprises following operating procedure:
(1) take supplementary material by proportioning;
(2) get Fructus Crataegi, Radix Glycyrrhizae, decocting, merge decocting liquid, and concentrating under reduced pressure obtains extractum;
(3) get extractum prepared by step (2), add calcium carbonate, lactose and starch, granulate, then add lubricant, mix, tabletting obtains chewable tablet.
Further, described extractum quality is 1/6～1/7 of Fructus Crataegi and Radix Glycyrrhizae total amount.
Further, the concrete operations of described decocting are as follows:
The water that adds 10～20 times of Fructus Crataegis, Radix Glycyrrhizae total amount, after immersion, decoct and extract 2～3 times, each 0.5～1.5h.
Preferably, the concrete operations of described decocting are as follows:
The water that adds 15 times of Fructus Crataegis, Radix Glycyrrhizae total amount, after immersion, decoct and extract 2 times, each 1h.
The present invention also provides the purposes of above-mentioned chewable tablet in the veterinary drug for preparing stomach invigorating, replenishes the calcium.
Further, described medicine is the pig medicine.
Chewable tablet of the present invention, appearance character is good, and mouthfeel and hardness are suitable, and the effect that has invigorating the stomach and promoting digestion, replenishes the calcium and increase weight can significantly promote the fowl dirty swine long, has higher clinical value.
The specific embodiment
The preparation of embodiment 1 chewable tablet of the present invention
Prescription:
Preparation technology
Take replenish the calcium Fructus Crataegi, the licorice piece of recipe quantity of chewable tablet of stomach invigorating, add the distilled water of 15 times of amounts, soak 30min, then decoct and extract 2 times, each 1h, merge decocting liquid twice, and concentrating under reduced pressure becomes the Fructus Crataegi Radix Glycyrrhizae extractum of 15g left and right, standby.Take lactose, the starch of recipe quantity again and after calcium carbonate is mixed homogeneously, add the Fructus Crataegi Radix Glycyrrhizae extractum fully to stir and make soft material, crossing 18 mesh sieves and granulate, aeration-drying under 70 ℃ of conditions, sieve and add magnesium stearate, mix homogeneously, and compression molding is both.
The preparation of embodiment 2 chewable tablet of the present invention
Prescription:
Preparation technology:
Take replenish the calcium Fructus Crataegi, the licorice piece of recipe quantity of chewable tablet of stomach invigorating, add the distilled water of 10 times of amounts, be dipped to the heart, then decoct and extract 3 times, each 0.5h, collecting decoction, be evaporated to extractum weight and be 1/6 of crude drug, standby.Take lactose, the starch of recipe quantity again and after calcium carbonate is mixed homogeneously, add the Fructus Crataegi Radix Glycyrrhizae extractum fully to stir and make soft material, crossing 18 mesh sieves and granulate, aeration-drying under 70 ℃ of conditions, sieve and add magnesium stearate, mix homogeneously, and compression molding is both.
The preparation of embodiment 3 chewable tablet of the present invention
Prescription:
Preparation technology:
Take replenish the calcium Fructus Crataegi, the licorice piece of recipe quantity of chewable tablet of stomach invigorating, add the distilled water of 20 times of amounts, be dipped to the heart, then decoct and extract 3 times, 1.5h, 1h, 0.5h for the third time for the second time for the first time, collecting decoction, be evaporated to extractum weight and be 1/7 of crude drug, standby.Take lactose, the starch of recipe quantity again and after calcium carbonate is mixed homogeneously, add the Fructus Crataegi Radix Glycyrrhizae extractum fully to stir and make soft material, crossing 18 mesh sieves and granulate, aeration-drying under 70 ℃ of conditions, sieve and add magnesium stearate, mix homogeneously, and compression molding is both.
Embodiment 4 prescription screenings
Prepare chewable tablet by embodiment 1 method, the crude drug consumption is as embodiment 1(Fructus Crataegi, Radix Glycyrrhizae, calcium carbonate), supplementary product kind and consumption are screened.
The screening of table 1 prescription adjuvant
According to the mensuration of the indexs such as the outward appearance to chewable tablet, hardness, disintegration time, mouthfeel, finally show that the tablet that uses mannitol to do filler is all partially soft, hardness is defective.Sucrose is cooked filler, and tablet appearance is not satisfied.Finally preferably going out optimum prescription is 7,9.According to the chewable tablet mouthfeel, optimize prescription 7 for final prescription.
Below illustrate beneficial effect of the present invention by test example.
Test example 1 clinical trial
Choose 20 of healthy pigletss, body weight is in 20 ± 1.5kg left and right.Be divided into two groups, normally feed as a control group for one group, outside another group is normally fed, give the chewable tablet of embodiment 1 preparation every day as test group, every two weeks is weighed, and obtains a result as following table 2.
Each first quarter moon average weight gain amount (kg) of table 2 piglets
As can be seen from the data, chewable tablet of the present invention has the effect that promotes the piglets growth, and average growth rate is far above the group of the chewable tablet of not feeding, stomach invigorating prepared by the present invention chewable tablet of replenishing the calcium is described, have invigorating the stomach and promoting digestion, the effect of the weightening finish of replenishing the calcium, have higher clinical value.
Claims (10)
1. a chewable tablet for animals is characterized in that: it is that supplementary material by following weight proportion is prepared from:
60～100 parts of Fructus Crataegis, 12～20 parts, Radix Glycyrrhizae, 25～35 parts of calcium carbonate, 40～50 parts of lactose, 5～15 parts of starch, lubricant are appropriate.
2. chewable tablet according to claim 1 is characterized in that: it is that supplementary material by following weight proportion is prepared from:
80 parts of Fructus Crataegis, 16 parts, Radix Glycyrrhizae, 30 parts of calcium carbonate, 45 parts of lactose, 10 parts of starch, lubricant are appropriate.
3. chewable tablet according to claim 1 and 2, it is characterized in that: described lubricant is selected from magnesium stearate.
4. chewable tablet according to claim 3, it is characterized in that: the consumption of described magnesium stearate is 0.5～2 part.
5. the preparation method of the described chewable tablet of claim 1～4 any one, it is characterized in that: it comprises following operating procedure:
(1) take supplementary material by proportioning;
(2) get Fructus Crataegi, Radix Glycyrrhizae, decocting, merge decocting liquid, and concentrating under reduced pressure obtains extractum;
(3) get extractum prepared by step (2), add calcium carbonate, lactose and starch, granulate, then add lubricant, mix, tabletting obtains chewable tablet.
6. preparation method according to claim 5, it is characterized in that: described extractum quality is 1/6～1/7 of Fructus Crataegi and Radix Glycyrrhizae total amount.
7. preparation method according to claim 5, it is characterized in that: the concrete operations of described decocting are as follows:
The water that adds 10～20 times of Fructus Crataegis, Radix Glycyrrhizae total amount, after immersion, decoct and extract 2～3 times, each 0.5～1.5h.
8. preparation method according to claim 7, it is characterized in that: the concrete operations of described decocting are as follows:
The water that adds 15 times of Fructus Crataegis, Radix Glycyrrhizae total amount, after immersion, decoct and extract 2 times, each 1h.
9. the purposes of the described chewable tablet of claim 1～4 any one in preparation stomach invigorating, the veterinary drug of replenishing the calcium.
10. purposes according to claim 9, it is characterized in that: described medicine is the pig medicine.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310473216.5A CN103494906B (en) | 2013-10-11 | 2013-10-11 | Chewable tablet for livestock, as well as preparation method and application of tablet |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310473216.5A CN103494906B (en) | 2013-10-11 | 2013-10-11 | Chewable tablet for livestock, as well as preparation method and application of tablet |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103494906A true CN103494906A (en) | 2014-01-08 |
| CN103494906B CN103494906B (en) | 2015-04-22 |
Family
ID=49860229
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201310473216.5A Expired - Fee Related CN103494906B (en) | 2013-10-11 | 2013-10-11 | Chewable tablet for livestock, as well as preparation method and application of tablet |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN103494906B (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105211886A (en) * | 2015-09-21 | 2016-01-06 | 大方县九龙天麻开发有限公司 | A kind of immunity regulating type Rhizoma gastrodiae beverage and preparation method thereof |
| CN106074798A (en) * | 2016-06-30 | 2016-11-09 | 信阳农林学院 | A kind of dog chewable tablet and preparation method thereof of replenishing the calcium |
| CN113663047A (en) * | 2021-08-31 | 2021-11-19 | 广州白云山奇星药业有限公司 | Composition with kidney tonifying and bone strengthening effects and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1352937A (en) * | 2000-11-03 | 2002-06-12 | 张学农 | Dispersed calcium carbonate-xylitol solid and chewing compound calcium carbonate tablet |
| US20120201882A1 (en) * | 2003-07-31 | 2012-08-09 | Delavau L.L.C. | Calcium carbonate granulation |
-
2013
- 2013-10-11 CN CN201310473216.5A patent/CN103494906B/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1352937A (en) * | 2000-11-03 | 2002-06-12 | 张学农 | Dispersed calcium carbonate-xylitol solid and chewing compound calcium carbonate tablet |
| US20120201882A1 (en) * | 2003-07-31 | 2012-08-09 | Delavau L.L.C. | Calcium carbonate granulation |
Non-Patent Citations (3)
| Title |
|---|
| 国家药典委员会编: "《中华人民共和国药典：2010年版.二部》", 31 January 2010, 中国中医药科技出版社 * |
| 学长2012: "山楂甘草茶", 《HTTP://BAIKE.BAIDU.COM/VIEW/8682235.HTM?FR=ALADDIN》 * |
| 沈文华: "母猪产后瘫痪的辨证施治", 《吉林畜牧兽医》 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105211886A (en) * | 2015-09-21 | 2016-01-06 | 大方县九龙天麻开发有限公司 | A kind of immunity regulating type Rhizoma gastrodiae beverage and preparation method thereof |
| CN106074798A (en) * | 2016-06-30 | 2016-11-09 | 信阳农林学院 | A kind of dog chewable tablet and preparation method thereof of replenishing the calcium |
| CN113663047A (en) * | 2021-08-31 | 2021-11-19 | 广州白云山奇星药业有限公司 | Composition with kidney tonifying and bone strengthening effects and preparation method thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN103494906B (en) | 2015-04-22 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102670994A (en) | Composition capable of relieving physical fatigue and preparation method of composition | |
| CN104983902A (en) | Traditional Chinese medicine composition for treating insomnia and dreaminess and preparation method and application thereof | |
| CN110584132A (en) | Special medical nutritional formula food for kidney diseases and preparation method thereof | |
| CN1806840A (en) | Chinese medicinal compound preparation and its preparing process | |
| CN101837087B (en) | Chinese medicinal composition for improving immunity, resisting fatigue and improving sexual function | |
| CN103494906B (en) | Chewable tablet for livestock, as well as preparation method and application of tablet | |
| CN103479754B (en) | Hypotensive drug and preparation method thereof | |
| CN104998168A (en) | Blood-enriching and qi-tonifying compound traditional Chinese lozenge and preparation technology thereof | |
| CN104587429A (en) | Ginger juice and honey impregnated American ginseng preparation and preparation method thereof | |
| CN102488881B (en) | Compound propolis composition for promoting pig growth and fattening as well as its preparation method | |
| CN104352821A (en) | Traditional Chinese medicine granule for treating hypertension | |
| CN104258359A (en) | Traditional Chinese medicine combination for curing pregnancy reaction and preparation method of preparations thereof | |
| CN102451260A (en) | Traditional Chinese medicine composition with function of alleviating fatigue and preparation method thereof | |
| CN109527573A (en) | A kind of nourishing yin and clearing heat Guiling Jelly and preparation method thereof | |
| CN102335387B (en) | Traditional Chinese medicine composition for treating liver stagnation, improving appetite and promoting digestion and preparation method thereof | |
| CN102335388B (en) | Chinese medicine composition for soothing liver, removing stagnation, stimulating appetite, and promoting digestion and preparation method thereof | |
| CN102552754B (en) | Compound propolis composition for promoting growth and fattening of livestock and preparation method thereof | |
| CN102145059B (en) | Chinese patent medicament for treating intractable hypertension | |
| CN105250747A (en) | Health maintenance paste | |
| CN104906547A (en) | Medicinal granules for treating spleen-qi deficiency type diarrhea associated with menstruation and preparation method of medicinal granules | |
| CN103330861B (en) | Medicine for curing cholera and preparation method thereof | |
| CN106728645A (en) | A kind of Traditional Chinese medicine compound composition of domestic animal lactagogue | |
| CN107737250A (en) | A kind of hypertension Chinese medicine composition and preparation method thereof | |
| CN101019979B (en) | Lactation promoting health product | |
| CN107007748A (en) | Improve Chinese medicine composition, medicine of physically weak symptom and its preparation method and application |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C56 | Change in the name or address of the patentee | ||
| CP01 | Change in the name or title of a patent holder |
Address after: 611130 Wenjiang, Chengdu, Chengdu cross strait science and Technology Industrial Development Zone, Jin Fu Road, Sichuan Patentee after: Chengdu Qiankun animal pharmaceutical Limited by Share Ltd Address before: 611130 Wenjiang, Chengdu, Chengdu cross strait science and Technology Industrial Development Zone, Jin Fu Road, Sichuan Patentee before: Chengdu Qiankun Animal Pharmaceutical Co.,Ltd. |
|
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20150422 Termination date: 20191011 |
|
| CF01 | Termination of patent right due to non-payment of annual fee |