CN103494607B - A kind of brain administration pipe laying sleeve pipe recording extracellular potential - Google Patents
A kind of brain administration pipe laying sleeve pipe recording extracellular potential Download PDFInfo
- Publication number
- CN103494607B CN103494607B CN201310460116.9A CN201310460116A CN103494607B CN 103494607 B CN103494607 B CN 103494607B CN 201310460116 A CN201310460116 A CN 201310460116A CN 103494607 B CN103494607 B CN 103494607B
- Authority
- CN
- China
- Prior art keywords
- pipe laying
- pipe
- cap
- nut
- sleeve pipe
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Landscapes
- Electrotherapy Devices (AREA)
Abstract
The invention discloses a kind of brain administration pipe laying sleeve pipe recording extracellular potential, this brain administration pipe laying sleeve pipe that can record extracellular potential comprises: pipe laying casing main body, electrode sleeve pipe, tube core cap, delivery tube, hold-down nut, wire electrode, tube core, pipe laying sleeve cap; The present invention by will stimulating, damage, administration, record, extraction tissue fluid function five in one, simplifies experimental implementation, reduces experimental cost, improve experiment success rate, improve motility and the accuracy of device; Structure of the present invention is simple, and easy to operate, cost of manufacture is low, and preferably resolve pipe laying administration sleeve pipe operating function in existing brain single, use cost is high, easily causes the problem of secondary injury.
Description
Technical field
The invention belongs to technical field of medical instruments, particularly relate to a kind of brain administration pipe laying sleeve pipe recording extracellular potential.
Background technology
In Neuroscience Research, in the technology that body research is current hot topic, usually physiological and pharmacological method, electrophysiological method is used, physiological pharmacology method comprises Naoliqing capsule pharmacology control, fixed point damage, tissue fluid extraction etc., electrophysiological method comprises the method for local field potentials, extracellular stimulus and record, need to use pipe laying sleeve pipe in brain in these techniques, micro-injection administration needle, extracellular eeg recording and stimulating electrode, electricity melts damage electrode, and in brain, pipe laying administration needle can meet the needs of Cerebrum nucleus Region-specificity administration; Extracellular eeg recording and stimulating electrode are used to record brain electricity or brain given to the stimulation of feature, and electricity melts damage electrode and is used to carry out stereoscopic localized electricity between Naokong and melts, and this is the important way of the function of damage research at present brain area and nucleus; Pipe laying sleeve pipe is meanwhile utilized to also have other functions (extract cerebrospinal fluid, administration needle uses perfusion instead or dialysis needle then realizes other functions).
In current brain, pipe laying administration sleeve pipe, extracellular eeg recording electrode and electricity melt damage electrode is isolated system respectively, but usually process and record are that this that carry out (process has pharmacology to control and damages, record extracellular recording and field potential change) needs drill two holes on laboratory animal head and need to repeat the wound that insertion two sub-electrode expands laboratory animal greatly simultaneously; Meanwhile because electrode is expendable consumed product, not only make experimental implementation become trouble, and add the expense of experiment equipment.
The device of current existence mostly can only a kind of function of complete independently, another device is then needed when another function of needs, more it should be noted that, if independent device completes each function, so need separately each device (electrode or pipe laying) to be positioned in brain, namely after laboratory animal brain respectively sphenotresia, stereoscopic localized operation is carried out, significantly increase operation cost like this, animal surgery complexity and the infringement to laboratory animal, especially laboratory animal is easily caused to destroy excessive and dead because of all brain structures or cannot successfully record brain electricity.
In existing brain, pipe laying administration sleeve pipe operating function is single, and use cost is high, easily causes secondary injury.
Summary of the invention
The object of the embodiment of the present invention is to provide a kind of brain administration pipe laying sleeve pipe recording extracellular potential, and be intended to solve pipe laying administration sleeve pipe operating function in existing brain single, use cost is high, easily causes the problem of secondary injury.
The embodiment of the present invention realizes like this, record a brain administration pipe laying sleeve pipe for extracellular potential, this brain administration pipe laying sleeve pipe that can record extracellular potential comprises: pipe laying casing main body, electrode sleeve pipe, tube core cap, delivery tube, hold-down nut, wire electrode, tube core, pipe laying sleeve cap;
Electrode sleeve pipe is arranged on the both sides of pipe laying casing main body, pipe laying sleeve cap is arranged on the top of pipe laying casing main body, tube core is arranged on the centre position of pipe laying casing main body, wire electrode is fixed on electrode inside pipe casing by hold-down nut, tube core cap is arranged on the top of tube core, hold-down nut is arranged on the both sides of pipe laying sleeve cap by the plastic cap being arranged on pipe laying sleeve cap, and delivery tube is arranged on die internal.
Further, pipe laying casing main body adopts plastic-steel material.
Further, pipe laying sleeve cap is made up of plastic material.
Further, wire electrode can be stimulating electrode silk or recording electrode silk.
Further, hold-down nut adopts the metal material of conduction to make.
Further, tube core adopts solid plastics-steel material to make, and tube core cap is set to semicircle ball-type.
Further, pipe laying sleeve cap arranges screw thread, and the screw thread of upper 1/3rd is used for being tightened with tube core cap, and lower 1/3rd screw threads are used for being fixed by dental cement and skull.
Further, the top of delivery tube is set to pencil glue head, and delivery tube glue head is set to taper shape, adopts the good plastic cement of elasticity to make.
Further, hold-down nut also comprises: nut head, nut draw-in groove, nut cap;
Nut head is arranged on the front end of hold-down nut, and nut draw-in groove is arranged on hold-down nut both sides, and nut cap is arranged on the end of hold-down nut.
Further, nut draw-in groove can connect wire, and in order to export or input electrical signal, nut cap arranges insulation layer, is cross or manifold.
The brain administration pipe laying sleeve pipe recording extracellular potential provided by the invention, by stimulating, damage, administration, record, extract tissue fluid function five in one, simplify experimental implementation, reduce experimental cost, improve experiment success rate, improve motility and the accuracy of device; This utility model structure is simple, and easy to operate, cost of manufacture is low, and preferably resolve pipe laying administration sleeve pipe operating function in existing brain single, use cost is high, easily causes the problem of secondary injury.
Accompanying drawing explanation
Fig. 1 is the structural representation of the brain administration pipe laying sleeve pipe of the recorded extracellular potential that the embodiment of the present invention provides;
Fig. 2 is the structural representation of the delivery tube that the embodiment of the present invention provides;
Fig. 3 is the structural representation of the hold-down nut that the embodiment of the present invention provides;
In figure: 1, pipe laying casing main body; 2, electrode sleeve pipe; 3, tube core cap; 4, delivery tube; 4-1, delivery tube glue head; 5, hold-down nut; 5-1, nut head; 5-2, nut draw-in groove; 5-3, nut cap; 6, wire electrode; 7, tube core; 8, pipe laying sleeve cap.
Detailed description of the invention
In order to make object of the present invention, technical scheme and advantage clearly understand, below in conjunction with embodiment, the present invention is further elaborated.Should be appreciated that specific embodiment described herein only in order to explain the present invention, be not intended to limit the present invention.
Below in conjunction with drawings and the specific embodiments, application principle of the present invention is further described.
As shown in Figure 1, the recorded extracellular potential of the embodiment of the present invention brain administration pipe laying sleeve pipe primarily of: pipe laying casing main body 1, electrode sleeve pipe 2, tube core cap 3, delivery tube 4, hold-down nut 5, wire electrode 6, tube core 7, pipe laying sleeve cap 8 form;
Electrode sleeve pipe 2 is arranged on the both sides of pipe laying casing main body 1, pipe laying casing main body 1 adopts plastic-steel material, pipe laying sleeve cap 8 is arranged on the top of pipe laying casing main body 1, pipe laying sleeve cap 8 is made up of plastic material, tube core 7 is arranged on the centre position of pipe laying casing main body 1, it is inner that wire electrode 6 is fixed on electrode sleeve pipe 2 by hold-down nut 5, tube core cap 3 is arranged on the top of tube core 7, hold-down nut 5 is arranged on the both sides of pipe laying sleeve cap 8, linked together by the plastic cap being arranged on pipe laying sleeve cap 8, it is inner that delivery tube 4 is arranged on tube core 7;
As shown in Figure 2, delivery tube glue head 4-1 is arranged on the top of delivery tube 4, delivery tube glue head 4-1 adopts the good plastic cement of elasticity to make can be freely movable, coning, delivery tube glue head 4-1 can relative motion thus control can block pipe laying sleeve cap 8 at the bottom of delivery tube 4 length, delivery tube glue head 4-1 and control delivery tube 4 insertion depth;
As shown in Figure 3, hold-down nut 5 of the present utility model comprises: nut head 5-1, nut draw-in groove 5-2, nut cap 5-3 form; Nut head 5-1 is arranged on the front end of hold-down nut 5, and nut draw-in groove 5-2 is arranged on hold-down nut 5 both sides, and nut cap 5-3 is arranged on the end of hold-down nut 5, nut draw-in groove 5-2 can connect wire, in order to export or input electrical signal, nut cap 5-3 has insulation layer, is cross or manifold; By the nut 5 that is tightened, nut head 5-1 contacts the wire electrode 6 in electrode sleeve pipe 2, and fixed electrode silk 6;
On pipe laying sleeve cap 8, the screw thread of 1/3rd is used for being tightened with tube core cap 3, and lower 1/3rd screw threads are used for being fixed by dental cement (surgical cement) and skull;
Wire electrode 6 can be stimulating electrode silk or recording electrode silk;
Hold-down nut 5 adopts the metal material of good conductivity to make;
Tube core 7 shields for solid prestige Steel material is made: prevent pipe laying cannula occlusion, prevent cerebrospinal fluid blood from overflowing; Tube core cap 3 semicircle ball-type, protection pipe laying sleeve pipe by extension;
Operation principle of the present utility model:
This utility model arranges electrode sleeve pipe 2 in the both sides of pipe laying casing main body 1, at the inner implant electrode silk 6 of motor sleeve pipe 2, wire electrode 6 can be recording electrode silk or stimulating electrode silk, realize pipe laying sleeve pipe record and stimulatory function, by hold-down nut 5, wire electrode 6 is fixed on electrode sleeve pipe 2, is set to pencil 4 in tube core 7 inside, achieve the function of administration and extraction tissue fluid, structure is simple, easy to operate.
The foregoing is only preferred embodiment of the present invention, not in order to limit the present invention, all any amendments done within the spirit and principles in the present invention, equivalent replacement and improvement etc., all should be included within protection scope of the present invention.
Claims (10)
1. one kind can be recorded the brain administration pipe laying sleeve pipe of extracellular potential, it is characterized in that, this brain administration pipe laying sleeve pipe that can record extracellular potential comprises: pipe laying casing main body, electrode sleeve pipe, tube core cap, delivery tube, hold-down nut, wire electrode, tube core, pipe laying sleeve cap;
Electrode sleeve pipe is arranged on the both sides of pipe laying casing main body, pipe laying sleeve cap is arranged on the top of pipe laying casing main body, tube core is arranged on the centre position of pipe laying casing main body, wire electrode is fixed on electrode inside pipe casing by hold-down nut, tube core cap is arranged on the top of tube core, hold-down nut is arranged on the both sides of pipe laying sleeve cap by the plastic cap being arranged on pipe laying sleeve cap, and delivery tube is arranged on die internal.
2. can record the brain administration pipe laying sleeve pipe of extracellular potential as claimed in claim 1, it is characterized in that, pipe laying casing main body adopts plastic-steel to make.
3. can record the brain administration pipe laying sleeve pipe of extracellular potential as claimed in claim 1, it is characterized in that, pipe laying sleeve cap is made up of plastic material.
4. can record the brain administration pipe laying sleeve pipe of extracellular potential as claimed in claim 1, it is characterized in that, wire electrode can be stimulating electrode silk or recording electrode silk.
5. can record the brain administration pipe laying sleeve pipe of extracellular potential as claimed in claim 1, it is characterized in that, hold-down nut adopts the metal material of conduction to make.
6. can record the brain administration pipe laying sleeve pipe of extracellular potential as claimed in claim 1, it is characterized in that, tube core adopts solid plastics-steel material to make, and tube core cap is set to semicircle ball-type.
7. can record the brain administration pipe laying sleeve pipe of extracellular potential as claimed in claim 1, it is characterized in that, pipe laying sleeve cap arranges screw thread, and the screw thread of upper 1/3rd is used for being tightened with tube core cap, and lower 1/3rd screw threads are used for being fixed by dental cement and skull.
8. can record the brain administration pipe laying sleeve pipe of extracellular potential as claimed in claim 1, it is characterized in that, the top of delivery tube is set to pencil glue head, and delivery tube glue head is set to taper shape, adopts Elastic plastic-rubber to make.
9. can record the brain administration pipe laying sleeve pipe of extracellular potential as claimed in claim 1, it is characterized in that, hold-down nut also comprises: nut head, nut draw-in groove, nut cap;
Nut head is arranged on the front end of hold-down nut, and nut draw-in groove is arranged on hold-down nut both sides, and nut cap is arranged on the end of hold-down nut.
10. can record the brain administration pipe laying sleeve pipe of extracellular potential as claimed in claim 9, it is characterized in that, nut draw-in groove connects wire, and in order to export or input electrical signal, nut cap arranges insulation layer, is cross or manifold.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310460116.9A CN103494607B (en) | 2013-09-29 | 2013-09-29 | A kind of brain administration pipe laying sleeve pipe recording extracellular potential |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310460116.9A CN103494607B (en) | 2013-09-29 | 2013-09-29 | A kind of brain administration pipe laying sleeve pipe recording extracellular potential |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103494607A CN103494607A (en) | 2014-01-08 |
| CN103494607B true CN103494607B (en) | 2016-03-02 |
Family
ID=49859940
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201310460116.9A Expired - Fee Related CN103494607B (en) | 2013-09-29 | 2013-09-29 | A kind of brain administration pipe laying sleeve pipe recording extracellular potential |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN103494607B (en) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104367314B (en) * | 2014-11-05 | 2017-07-14 | 中国科学院深圳先进技术研究院 | Electrode assembly for carrying out acute record |
| CN104367319A (en) * | 2014-11-05 | 2015-02-25 | 中国科学院深圳先进技术研究院 | Electrode device for chronic recording |
| CN107198592A (en) * | 2017-05-16 | 2017-09-26 | 于生元 | Rat inflammation soup stimulates model and method for building up |
| CN112120695A (en) * | 2020-09-29 | 2020-12-25 | 中国科学院上海微系统与信息技术研究所 | Deep flexible brain electrode combined with drug delivery channel and preparation method thereof |
| CN112656535A (en) * | 2021-01-04 | 2021-04-16 | 中国人民解放军空军军医大学 | Optical fiber connection photobiological treatment window for rats |
Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN2754557Y (en) * | 2004-12-13 | 2006-02-01 | 谭坤 | Intracranical deep electrode |
| CN1911470A (en) * | 2006-07-28 | 2007-02-14 | 中国科学院上海微系统与信息技术研究所 | Implantation micro-electrode having integrated medicinal agent releasing function, its manufacturing method and application |
| JP4163745B1 (en) * | 2008-05-07 | 2008-10-08 | 日本ライフライン株式会社 | Electrode catheter |
| CN101804240A (en) * | 2010-03-18 | 2010-08-18 | 山西医科大学 | Stimulation, recording and administration combined device for research on use of hippocampal field potentials of mouse and rat |
| CN101822857A (en) * | 2010-04-06 | 2010-09-08 | 陈丽晔 | Medicinal instrument combined electric pulse generation and lead-in device |
| US8229539B1 (en) * | 2011-02-25 | 2012-07-24 | Tohoku-Microtec Co., Ltd. | Brain probe and method for manufacturing same |
| CN202761829U (en) * | 2012-09-21 | 2013-03-06 | 复旦大学附属华山医院 | Stem cell transplantation helix electrode used for ventriculus dexter |
| CN103040537A (en) * | 2012-12-22 | 2013-04-17 | 中国人民解放军第四军医大学 | Trace drug delivery and changing device utilizing electroosmosis/pressure technology and application and manufacturing method of trace drug delivery and changing device |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050027338A1 (en) * | 2003-07-29 | 2005-02-03 | Advanced Neuromodulation Systems, Inc. | Stretchable lead body, method of manufacture, and system |
| WO2005123182A2 (en) * | 2004-06-11 | 2005-12-29 | University Of South Florida | Nervous tissue electrode device |
-
2013
- 2013-09-29 CN CN201310460116.9A patent/CN103494607B/en not_active Expired - Fee Related
Patent Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN2754557Y (en) * | 2004-12-13 | 2006-02-01 | 谭坤 | Intracranical deep electrode |
| CN1911470A (en) * | 2006-07-28 | 2007-02-14 | 中国科学院上海微系统与信息技术研究所 | Implantation micro-electrode having integrated medicinal agent releasing function, its manufacturing method and application |
| JP4163745B1 (en) * | 2008-05-07 | 2008-10-08 | 日本ライフライン株式会社 | Electrode catheter |
| CN101804240A (en) * | 2010-03-18 | 2010-08-18 | 山西医科大学 | Stimulation, recording and administration combined device for research on use of hippocampal field potentials of mouse and rat |
| CN101822857A (en) * | 2010-04-06 | 2010-09-08 | 陈丽晔 | Medicinal instrument combined electric pulse generation and lead-in device |
| US8229539B1 (en) * | 2011-02-25 | 2012-07-24 | Tohoku-Microtec Co., Ltd. | Brain probe and method for manufacturing same |
| CN202761829U (en) * | 2012-09-21 | 2013-03-06 | 复旦大学附属华山医院 | Stem cell transplantation helix electrode used for ventriculus dexter |
| CN103040537A (en) * | 2012-12-22 | 2013-04-17 | 中国人民解放军第四军医大学 | Trace drug delivery and changing device utilizing electroosmosis/pressure technology and application and manufacturing method of trace drug delivery and changing device |
Also Published As
| Publication number | Publication date |
|---|---|
| CN103494607A (en) | 2014-01-08 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN103494607B (en) | A kind of brain administration pipe laying sleeve pipe recording extracellular potential | |
| CN201612673U (en) | Improved peripheral nerve block retaining trocar | |
| CN103040537B (en) | Trace drug delivery and changing device utilizing electroosmosis/pressure technology and application and manufacturing method of trace drug delivery and changing device | |
| CN110013346A (en) | A kind of integrated apparatus recorded for the administration of rat brain area and electroneurographic signal | |
| CN206613034U (en) | It is a kind of to be used for cup-shape electrode of the minitype animal experiment through cranium galvanic current stimulation | |
| CN209153668U (en) | A kind of brain electric equipment with RF coagulation | |
| CN203555798U (en) | Novel buried pipe core for brain drug feeding | |
| CN104874093A (en) | Cerebrospinal fluid extracting device | |
| CN207186616U (en) | A kind of fibril electrode array of implanted acquiring brain waves | |
| CN204337030U (en) | A kind of Combined bone screw | |
| CN209595862U (en) | A kind of Pain Management anesthetic care device | |
| CN203291374U (en) | Cervix medicine applying device | |
| CN207768835U (en) | A kind of medical trocar with protection | |
| CN202459649U (en) | Non-invasive syringe needle | |
| CN204542218U (en) | A kind of Neonate puncture needle | |
| CN203736230U (en) | Electric heating coating device for B-ultrasonic sound conducting gel of function department | |
| CN203075361U (en) | Novel injection syringe | |
| CN204261145U (en) | Disposable syringe | |
| CN203280827U (en) | Intracerebral multi-point injection scalp embedment liquid guide bag | |
| CN201375750Y (en) | Hermetic vein three-way indwelling needle | |
| CN203677606U (en) | Thoracic puncture needle capable of being fixed by single person | |
| CN215995121U (en) | Medical infusion auxiliary tool | |
| CN201643235U (en) | Injection needle protection device | |
| CN203075317U (en) | Automatic filling device of infusion apparatus | |
| CN206729969U (en) | Guider guide pin |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| ASS | Succession or assignment of patent right |
Owner name: NO.3 ARMY MEDICAL UNIV., PLA Free format text: FORMER OWNER: ZHANG KAIYUAN Effective date: 20131230 |
|
| C41 | Transfer of patent application or patent right or utility model | ||
| C53 | Correction of patent of invention or patent application | ||
| CB03 | Change of inventor or designer information |
Inventor after: Zhang Kaiyuan Inventor after: Zhang Jiqiang Inventor after: Lan Chunhui Inventor after: Liao Shengtao Inventor after: Liu Chang Inventor before: Zhang Kaiyuan Inventor before: Zhang Jiqiang Inventor before: Liao Shengtao |
|
| COR | Change of bibliographic data |
Free format text: CORRECT: INVENTOR; FROM: ZHANG KAIYUAN ZHANG JIQIANG LIAO SHENGTAO TO: ZHANG KAIYUAN ZHANG JIQIANG LAN CHUNHUI LIAO SHENGTAO LIU CHANG |
|
| TA01 | Transfer of patent application right |
Effective date of registration: 20131230 Address after: Chongqing city Shapingba street 400038 gaotanyan No. 30 Applicant after: THIRD MILITARY MEDICAL University Address before: Chongqing city Shapingba street 400038 gaotanyan No. 30 of No. 34 Applicant before: Zhang Kaiyuan |
|
| DD01 | Delivery of document by public notice |
Addressee: THIRD MILITARY MEDICAL University Document name: Notification of Passing Preliminary Examination of the Application for Invention |
|
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| CB03 | Change of inventor or designer information |
Inventor after: Zhang Kaiyuan Inventor after: Zhang Jiqiang Inventor after: Liao Shengtao Inventor after: Ge Hongfei Inventor after: Tan Liang Inventor after: Hu Rong Inventor after: Liu Xin Inventor after: Feng Hua Inventor before: Zhang Kaiyuan Inventor before: Zhang Jiqiang Inventor before: Lan Chunhui Inventor before: Liao Shengtao Inventor before: Liu Chang |
|
| COR | Change of bibliographic data | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20160302 Termination date: 20210929 |