CN110013346A - A kind of integrated apparatus recorded for the administration of rat brain area and electroneurographic signal - Google Patents
A kind of integrated apparatus recorded for the administration of rat brain area and electroneurographic signal Download PDFInfo
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- CN110013346A CN110013346A CN201910394741.5A CN201910394741A CN110013346A CN 110013346 A CN110013346 A CN 110013346A CN 201910394741 A CN201910394741 A CN 201910394741A CN 110013346 A CN110013346 A CN 110013346A
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- 210000004556 brain Anatomy 0.000 title claims abstract description 38
- 239000007787 solid Substances 0.000 claims abstract description 53
- 239000003814 drug Substances 0.000 claims description 10
- 230000005611 electricity Effects 0.000 claims description 9
- 238000002347 injection Methods 0.000 claims description 9
- 239000007924 injection Substances 0.000 claims description 9
- 229920000297 Rayon Polymers 0.000 claims description 5
- 239000003292 glue Substances 0.000 claims description 5
- 239000007788 liquid Substances 0.000 claims description 5
- 210000003625 skull Anatomy 0.000 claims description 5
- 238000009434 installation Methods 0.000 claims description 4
- 238000003466 welding Methods 0.000 claims description 2
- 230000000694 effects Effects 0.000 abstract description 10
- 210000005036 nerve Anatomy 0.000 abstract description 9
- 230000001154 acute effect Effects 0.000 abstract description 4
- 230000003447 ipsilateral effect Effects 0.000 abstract description 4
- 230000002618 waking effect Effects 0.000 abstract description 3
- 238000002474 experimental method Methods 0.000 abstract description 2
- 238000012544 monitoring process Methods 0.000 abstract description 2
- 210000005013 brain tissue Anatomy 0.000 description 7
- 238000010586 diagram Methods 0.000 description 7
- 208000027418 Wounds and injury Diseases 0.000 description 6
- 239000012530 fluid Substances 0.000 description 5
- 238000000034 method Methods 0.000 description 5
- 229940079593 drug Drugs 0.000 description 4
- 230000005540 biological transmission Effects 0.000 description 3
- 230000006378 damage Effects 0.000 description 3
- 238000012377 drug delivery Methods 0.000 description 3
- 210000001320 hippocampus Anatomy 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- 206010002091 Anaesthesia Diseases 0.000 description 2
- 230000037005 anaesthesia Effects 0.000 description 2
- 238000010171 animal model Methods 0.000 description 2
- 239000012153 distilled water Substances 0.000 description 2
- 239000002699 waste material Substances 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 1
- 208000010513 Stupor Diseases 0.000 description 1
- 230000006399 behavior Effects 0.000 description 1
- 230000002490 cerebral effect Effects 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 230000010354 integration Effects 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000000877 morphologic effect Effects 0.000 description 1
- 230000001766 physiological effect Effects 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
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- A—HUMAN NECESSITIES
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- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
- A61B5/25—Bioelectric electrodes therefor
- A61B5/279—Bioelectric electrodes therefor specially adapted for particular uses
- A61B5/291—Bioelectric electrodes therefor specially adapted for particular uses for electroencephalography [EEG]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
- A61B5/316—Modalities, i.e. specific diagnostic methods
- A61B5/369—Electroencephalography [EEG]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
- A61B5/316—Modalities, i.e. specific diagnostic methods
- A61B5/369—Electroencephalography [EEG]
- A61B5/377—Electroencephalography [EEG] using evoked responses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
- A61B5/6846—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive
- A61B5/6867—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive specially adapted to be attached or implanted in a specific body part
- A61B5/6868—Brain
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
- A61D7/00—Devices or methods for introducing solid, liquid, or gaseous remedies or other materials into or onto the bodies of animals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B2503/00—Evaluating a particular growth phase or type of persons or animals
- A61B2503/40—Animals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B2503/00—Evaluating a particular growth phase or type of persons or animals
- A61B2503/42—Evaluating a particular growth phase or type of persons or animals for laboratory research
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Abstract
The invention belongs to electroneurographic signal recording equipment technical fields, more particularly to a kind of integrated apparatus recorded for the administration of rat brain area and electroneurographic signal, including link block, circuit board, solid symbol electrode, hollow recording electrode of L-type etc., the circuit board is located at the upper surface middle part of link block, and the connecting plate connection on the interconnecting piece and link block on circuit board, four solid symbol electrodes and a hollow recording electrode of L-type are connect with the interconnecting piece on circuit board, the present invention solves conventional wireless nerve signal recording electrode and there was only simple record effect, can not intracerebral administration after instantaneous record electrical activity of brain, and there can be the phenomenon that certain experiment interference between traditional intracerebral administration mode and conventional wireless nerve signal recording electrode, realize can it is ipsilateral realization and meanwhile carry out intracerebral administration and electroneurographic signal record , can also accomplish acute administration, the variation of rat electrical activity of brain in front and back and administration is administered under real-time monitoring waking state.
Description
Technical field
The invention belongs to electroneurographic signal recording equipment technical fields, and in particular to one kind is for the administration of rat brain area and mind
The integrated apparatus recorded through electric signal.
Background technique
Intracerebral is wireless nerve signal record system can overcome the shortcomings of wired nerve signal record system, allow experimental animal
It move freely with not being bound, is gradually applied in the research of Neurobiology.Wireless nerve signal records system simultaneously
Have the advantages that for a long time, animal electrical activity of brain under dynamically recording waking state, record data closer to experimental animal just
Normal physiological activity.
But conventional wireless nerve signal recording electrode only has simple record effect, can not the instantaneous record after intracerebral administration
Electrical activity of brain.It since the volume of electrode is larger, and is to be fixed on greatly and after the installation of conventional wireless nerve signal recording electrode
Mouse head, when we need in the administration of ipsilateral intracerebral, intracerebral injection operation can become highly difficult.Carrying out certain experiments
When, acute administration in rat hippocampus is needed, observes the variation of rat electrical activity of brain after administration immediately, due to traditional technology condition
Limitation, the change of rat electrical activity of brain after acute administration under narcosis can only be observed, and cannot achieve Behaviors survey with
The combination of electrical activity of brain.
The intracerebral administration mode that we generally use at present be telocoele pipe laying administration method or use microsyringe
Locating injection is carried out in intracerebral.But every kind of medication has its disadvantage when in conjunction with wireless nerve signal record system.Make
With microsyringe when intracerebral carries out locating injection, requires to relocate before administration every time, meeting repeatedly is administered with administration needle
It does great damage to rat cerebral tissue, influences experimental result, can also waste a large amount of man power and material；Using telocoele pipe laying
When the method for administration, the position of wireless nerve signal recording electrode installation can be occupied, causes electrode that can not install with ventricles of the brain pipe laying
Ipsilateral, since ventricles of the brain pipe laying is thicker, brain tissue can be damaged by pricking in human brain tissue, influence experimental result.And in side
When ventricles of the brain pipe laying, it may appear that can not be accurately positioned, situation about can not directly be given to drug in brain tissue leads to the waste of drug
It is undesirable with experimental result.
Summary of the invention
The present invention, aiming to the above problems, provides a kind of integrations recorded for the administration of rat brain area and electroneurographic signal
Device.
The invention adopts the following technical scheme in order to achieve the above objectives:
A kind of integrated apparatus recorded for the administration of rat brain area and electroneurographic signal, including link block, circuit board, reality
The hollow recording electrode of heart recording electrode, L-type, two ground wires and four connecting lines,
Multiple connecting plates are equipped in the link block upper surface, two rows is symmetrical arranged into before and after multiple connecting plates, is connecting
The lower surface of block is equipped with connecting hole corresponding with each connecting plate, and the circuit board is located at the upper surface middle part of link block and position
In the centre of two rows of connecting plates, muti-piece connection position is respectively provided in two sides of circuit board, each connection position and corresponding connection
Plate is connected, and the quantity of the solid symbol electrode is four, and the quantity of the hollow recording electrode of L-type is one, two therein
Solid symbol electrode constitutes first group, and remaining two solid symbol electrodes and the hollow recording electrode of L-type constitute second group and L-type
The vertical end of hollow recording electrode is located at the centre of remaining two solid symbol electrodes, and first group and second group is separately positioned on electricity
The two sides of road plate, every solid symbol electrode and the hollow recording electrode of L-type are all connected with one of connection position of the same side,
The remaining connecting plate that place is arranged is divided into left and right two parts respectively by first group and second group, and each section connecting plate is connected in parallel
On a piece connecting line, the transverse end of the hollow recording electrode of L-type extends to the outside of circuit board left or right side, two ground wires
One end be connected respectively with being located at circuit board two sides and belong to two connecting lines of left or right side, two ground wires
The other end is respectively wound around on a screw and connect with the skull of mouse.
Further, it is equipped with plunger, at the transverse port of the hollow recording electrode of the L-type to prevent in not liquid medicine injection
In the case of, mouse brain is infected.
Further, the middle part of two sides of circuit board is arranged in the solid symbol electrode and the hollow recording electrode of L-type,
To facilitate the installation and welding of solid symbol electrode and the hollow recording electrode of L-type.
Further, the centre of connection position and connecting plate is arranged in the solid symbol electrode and the hollow recording electrode of L-type,
Preferably to fix solid symbol electrode and the hollow recording electrode of L-type.
Further, the upper surface of link block is arranged in the transverse end of the hollow recording electrode of the L-type, and hollow in L-type
The transverse end of recording electrode and the contact site of link block upper surface are equipped with viscose glue, to fix the transverse direction of the hollow recording electrode of L-type
End.
Further, the diameter of the solid symbol electrode is 0.15-0.35mm.
Further, the outer diameter of the hollow recording electrode of the L-type is 0.50-0.75mm, and internal diameter is 0.20-0.30mm.
Further, the distance between the solid symbol electrode and the hollow recording electrode of L-type A are 0.3mm.
Further, the solid symbol electrode is 4- beyond circuit board top distance B with the hollow recording electrode of L-type
6mm。
Further, the diameter of plug is 0.30-0.50mm on the plunger 6.
Compared with prior art the invention has the following advantages that
1, the hollow recording electrode of L-type of the present invention can it is ipsilateral realization and meanwhile carry out intracerebral administration and neuroelectricity
Signal record can also accomplish acute administration, rat brain electricity before and after administration and in administration process under real-time monitoring waking state
Movable variation；
2, the hollow recording electrode of L-type of the present invention may be implemented to be administered at any time, convenient and efficient；Simultaneously as needed
It is connected from different drug delivery devices, freedom degree is higher；And the hollow recording electrode of L-type is thinner compared to pipe laying, to the damage of brain tissue
Wound is smaller, does not also need multiple inserting needle by the hollow recording electrode administration of L-type, secondary injury will not be caused to brain tissue, in this way
It can accomplish the long-term multiple dosing of intracerebral, the complete brain tissue in side can also be retained, be convenient for subsequent Morphological Experimental；L
The hollow recording electrode administration of type can directly be given to brain tissue, and accurate positioning, administration precision is high, and brain group is administered compared to telocoele
It is more obvious to knit interior administration effect, needs the dosage of drug smaller；
Detailed description of the invention
Fig. 1 is the structural schematic diagram of Example 1 and Example 2 of the present invention；
Fig. 2 is the structural schematic diagram of link block of the present invention；
Fig. 3 is the structural schematic diagram of circuit board of the present invention；
Fig. 4 is the structural schematic diagram of link block of the present invention；
Fig. 5 is front view of the invention；
Fig. 6 is the structural schematic diagram of the hollow recording electrode of L-type of the present invention；
Fig. 7 is usage state diagram of the present invention by the hollow recording electrode administration of L-type；
Fig. 8 is the structural schematic diagram of the embodiment of the present invention 3；
Wherein link block -1, circuit board -2, solid symbol electrode -3, L-type 4, two ground wires-of hollow recording electrode -
5,6, four connecting lines -7 of plunger -, drug delivery device -8, hose -9, syringe needle -10, connecting plate -101, connecting hole -102,
Connection position -201.
Specific embodiment
For the technical solution that the present invention is further explained, the present invention is carried out with reference to the accompanying drawings and embodiments further
Explanation.
Embodiment 1
As shown in Figures 1 to 6, a kind of integrated apparatus recorded for the administration of rat brain area and electroneurographic signal, including
4, two ground wires 5 of the hollow recording electrode of link block 1, circuit board 2, solid symbol electrode 3, L-type and four connecting lines 7,
Two rows are symmetrical arranged into before and after 1 upper surface of link block is equipped with 10 connecting plates, 101,10 connecting plates 101,
It is equipped with connecting hole 102 corresponding with each connecting plate 101 in the lower surface of link block 1, connecting hole 102 is sent out for connection signal
Emitter, to realize that wireless transmission electroneurographic signal, the circuit board 2 are located at the upper surface middle part of link block 1 and are located at two rows of connect
The centre of fishplate bar 101 is respectively provided with 10 pieces of connection positions 201 in two sides of circuit board 2, each connection position 201 and corresponding company
Fishplate bar 101 is connected, and the diameter of the solid symbol electrode 3 is 0.15mm, and quantity is four, outside the hollow recording electrode 4 of L-type
Diameter is 0.50mm, and internal diameter 0.20mm, quantity is one, first group of two solid symbol electrodes 3 composition therein, remaining two
Root solid symbol electrode 3 and the hollow recording electrode 4 of L-type constitute second group and the vertical end of the hollow recording electrode 4 of L-type is located at residue
The centre of two solid symbol electrodes 3, the distance between solid symbol electrode 3 and the hollow recording electrode 4 of L-type A are 0.3mm.The
The one group and second group middle part for being separately positioned on 2 two sides of circuit board, and every solid symbol electrode 3 and the hollow record electricity of L-type
Pole 4 is respectively positioned on the centre of corresponding connection position 201 and connecting plate 101, the solid symbol electrode 3 and the hollow record electricity of L-type
Distance B of the pole 4 beyond 2 top of circuit board is 4mm, and first group and second group is respectively divided into the remaining connecting plate 101 that place is arranged
Left and right two parts, each section connecting plate 101 are connected in parallel on a connecting line 7, the cross of the hollow recording electrode 4 of L-type
The upper surface of link block 1 is set to end, and extends to the outside in 2 left side of circuit board, and in the cross of the hollow recording electrode 4 of L-type
The contact site of 1 upper surface of Xiang Duanyu link block is equipped with viscose glue, to fix the transverse end of the hollow recording electrode 4 of L-type, the L-type
Plunger 6 is equipped at the transverse port of hollow recording electrode 4, to prevent in the case where not liquid medicine injection, mouse brain is infected,
The diameter of plug is 0.30mm on the plunger 6.One end of two ground wires 52 two sides of circuit board and is belonged to being located at respectively
Two connecting lines 7 in left or right side are connected, the other end of two ground wires 5 be respectively wound around on a screw with it is small
The skull of mouse connects.
Embodiment 2
As shown in Figures 1 to 6, a kind of integrated apparatus recorded for the administration of rat brain area and electroneurographic signal, including
4, two ground wires 5 of the hollow recording electrode of link block 1, circuit board 2, solid symbol electrode 3, L-type and four connecting lines 7,
Two rows are symmetrical arranged into before and after 1 upper surface of link block is equipped with 10 connecting plates, 101,10 connecting plates 101,
It is equipped with connecting hole 102 corresponding with each connecting plate 101 in the lower surface of link block 1, connecting hole 102 is sent out for connection signal
Emitter, to realize that wireless transmission electroneurographic signal, the circuit board 2 are located at the upper surface middle part of link block 1 and are located at two rows of connect
The centre of fishplate bar 101 is respectively provided with 10 pieces of connection positions 201 in two sides of circuit board 2, each connection position 201 and corresponding company
Fishplate bar 101 is connected, and the diameter of the solid symbol electrode 3 is 0.35mm, and quantity is four, outside the hollow recording electrode 4 of L-type
Diameter is 0.75mm, and internal diameter 0.30mm, quantity is one, first group of two solid symbol electrodes 3 composition therein, remaining two
Root solid symbol electrode 3 and the hollow recording electrode 4 of L-type constitute second group and the vertical end of the hollow recording electrode 4 of L-type is located at residue
The centre of two solid symbol electrodes 3, the distance between solid symbol electrode 3 and the hollow recording electrode 4 of L-type A are 0.3mm.The
The one group and second group middle part for being separately positioned on 2 two sides of circuit board, and every solid symbol electrode 3 and the hollow record electricity of L-type
Pole 4 is respectively positioned on the centre of corresponding connection position 201 and connecting plate 101, the solid symbol electrode 3 and the hollow record electricity of L-type
Distance B of the pole 4 beyond 2 top of circuit board is 6mm, and first group and second group is respectively divided into the remaining connecting plate 101 that place is arranged
Left and right two parts, each section connecting plate 101 are connected in parallel on a connecting line 7, the cross of the hollow recording electrode 4 of L-type
The upper surface of link block 1 is set to end, and extends to the outside in 2 left side of circuit board, and in the cross of the hollow recording electrode 4 of L-type
The contact site of 1 upper surface of Xiang Duanyu link block is equipped with viscose glue, to fix the transverse end of the hollow recording electrode 4 of L-type, the L-type
Plunger 6 is equipped at the transverse port of hollow recording electrode 4, to prevent in the case where not liquid medicine injection, mouse brain is infected,
The diameter of plug is 0.40mm on the plunger 6.One end of two ground wires 52 two sides of circuit board and is belonged to being located at respectively
Two connecting lines 7 in left or right side are connected, the other end of two ground wires 5 be respectively wound around on a screw with it is small
The skull of mouse connects.
Embodiment 3
As shown in Figures 1 to 6, a kind of integrated apparatus recorded for the administration of rat brain area and electroneurographic signal, including
4, two ground wires 5 of the hollow recording electrode of link block 1, circuit board 2, solid symbol electrode 3, L-type, plunger 6 and four connecting lines 7,
Two rows are symmetrical arranged into before and after 1 upper surface of link block is equipped with 10 connecting plates, 101,10 connecting plates 101,
It is equipped with connecting hole 102 corresponding with each connecting plate 101 in the lower surface of link block 1, connecting hole 102 is sent out for connection signal
Emitter, to realize that wireless transmission electroneurographic signal, the circuit board 2 are located at the upper surface middle part of link block 1 and are located at two rows of connect
The centre of fishplate bar 101 is respectively provided with 10 pieces of connection positions 201 in two sides of circuit board 2, each connection position 201 and corresponding company
Fishplate bar 101 is connected, and the diameter of the solid symbol electrode 3 is 0.25mm, and quantity is four, outside the hollow recording electrode 4 of L-type
Diameter is 0.60mm, and internal diameter 0.25mm, quantity is one, first group of two solid symbol electrodes 3 composition therein, remaining two
Root solid symbol electrode 3 and the hollow recording electrode 4 of L-type constitute second group and the vertical end of the hollow recording electrode 4 of L-type is located at residue
The centre of two solid symbol electrodes 3, the distance between solid symbol electrode 3 and the hollow recording electrode 4 of L-type A are 0.3mm.The
The one group and second group middle part for being separately positioned on 2 two sides of circuit board, and every solid symbol electrode 3 and the hollow record electricity of L-type
Pole 4 is respectively positioned on the centre of corresponding connection position 201 and connecting plate 101, the solid symbol electrode 3 and the hollow record electricity of L-type
Distance B of the pole 4 beyond 2 top of circuit board is 5mm, and first group and second group is respectively divided into the remaining connecting plate 101 that place is arranged
Left and right two parts, each section connecting plate 101 are connected in parallel on a connecting line 7, the cross of the hollow recording electrode 4 of L-type
The upper surface of link block 1 is set to end, and extends to the outside on 2 right side of circuit board, and in the cross of the hollow recording electrode 4 of L-type
The contact site of 1 upper surface of Xiang Duanyu link block is equipped with viscose glue, to fix the transverse end of the hollow recording electrode 4 of L-type, the L-type
Plunger 6 is equipped at the transverse port of hollow recording electrode 4, to prevent in the case where not liquid medicine injection, mouse brain is infected,
The diameter of plug is 0.50mm on the plunger 6.One end of two ground wires 52 two sides of circuit board and is belonged to being located at respectively
Two connecting lines 7 in left or right side are connected, the other end of two ground wires 5 be respectively wound around on a screw with it is small
The skull of mouse connects.
Application method
1, solid symbol electrode 3 of the invention and the hollow recording electrode 4 of L-type are exceeded to the part of circuit board 2 as needed
It is mounted on rat deep brain area (by taking hippocampus as an example, 3.5mm after bregma, 2.5mm, depth 2.5-2.8mm are opened in side), and with dentistry water
Mud is fixed；
2, need the hippocampus ventricles of the brain when being administered with gas anesthesia machine by rat anesthesia；
3, distilled water will first should be filled when drawing medical fluid in hose 9, drug delivery device 10, which is in, " to be taken medicine scale, draw 2 microlitres
Air makes have one section of reserved air in hose 9, then draws required medical fluid, medical fluid can be made to separate with distilled water in this way, side
Just it injects；
4, plunger 6 is removed, syringe needle 10 (diameter is 0.15-0.25mm) is extend into the hollow recording electrode 4 of L-type, should be infused
The inclined-plane of meaning syringe needle 10 facilitates medical fluid to inject the hollow recording electrode 4 of L-type towards the vertical extreme direction of the hollow recording electrode 4 of L-type
It is interior；
5, it is slowly injected into medical fluid, syringe needle 10 is extracted from the hollow recording electrode 4 of L-type after injection, plunger 6 is pacified
Good, administration terminates.
Claims (10)
1. a kind of integrated apparatus recorded for the administration of rat brain area and electroneurographic signal, it is characterised in that: including link block
(1), circuit board (2), solid symbol electrode (3), the hollow recording electrode of L-type (4), two ground wires (5) and 4 connecting lines (7),
Multiple connecting plates (101) are equipped in the link block (1) upper surface, are symmetrical arranged into two before and after multiple connecting plates (101)
Row is equipped with connecting hole (102) corresponding with each connecting plate (101), the circuit board (2) in the lower surface of link block (1)
It is located at the upper surface middle part of link block (1) and is located at the centre of two rows of connecting plates (101), it is each in two sides of circuit board (2)
Equipped with muti-piece connection position (201), each connection position (201) is connected with corresponding connecting plate (101), the solid symbol electrode
(3) quantity is four, and the quantity of the hollow recording electrode of L-type (4) is one, and two solid symbol electrodes (3) therein are constituted
First group, remaining two solid symbol electrodes (3) and the hollow recording electrode of L-type (4) constitute second group and the hollow record electricity of L-type
The vertical end of pole (4) is located at the centre of remaining two solid symbol electrodes (3), and first group and second group is separately positioned on circuit board
(2) two sides, the one of connection position of every solid symbol electrode (3) and the hollow recording electrode of L-type (4) all with the same side
(201) it is connected, the remaining connecting plate (101) that place is arranged is divided into left and right two parts, each portion respectively by first group and second group
Connecting plate (101) are divided to be connected in parallel on a connecting line (7), the transverse end of the hollow recording electrode of L-type (4) extends to circuit board
(2) outside of left or right side, one end of two ground wires (5) respectively be located at circuit board (2) two sides and belong to left side
Or two connecting lines (7) on right side are connected, the other end of two ground wires (5) is respectively wound around on a screw and mouse
Skull connection.
2. a kind of integrated apparatus recorded for the administration of rat brain area and electroneurographic signal according to claim 1,
It is characterized in that: plunger (6) is equipped at the transverse port of the hollow recording electrode of the L-type (4), to prevent in not liquid medicine injection
In the case of, mouse brain is infected.
3. a kind of integrated apparatus recorded for the administration of rat brain area and electroneurographic signal according to claim 1,
Be characterized in that: the solid symbol electrode (3) and the hollow recording electrode of L-type (4) are arranged in (2) two sides of circuit board
Portion, to facilitate the installation and welding of solid symbol electrode (3) and the hollow recording electrode of L-type (4).
4. a kind of integrated apparatus recorded for the administration of rat brain area and electroneurographic signal according to claim 3,
Be characterized in that: the solid symbol electrode (3) and the hollow recording electrode of L-type (4) are arranged in connection position (201) and connecting plate
(101) centre, preferably to fix solid symbol electrode (3) and the hollow recording electrode of L-type (4).
5. a kind of integrated apparatus recorded for the administration of rat brain area and electroneurographic signal according to claim 1,
Be characterized in that: the transverse end of the hollow recording electrode of L-type (4) is arranged in the upper surface of link block (1), and in the hollow note of L-type
The contact site of the transverse end and link block (1) upper surface of recording electrode (4) is equipped with viscose glue, to fix the hollow recording electrode of L-type (4)
Transverse end.
6. a kind of integrated apparatus recorded for the administration of rat brain area and electroneurographic signal according to claim 1,
Be characterized in that: the diameter of the solid symbol electrode (3) is 0.15-0.35mm.
7. a kind of integrated apparatus recorded for the administration of rat brain area and electroneurographic signal according to claim 1,
Be characterized in that: the outer diameter of the hollow recording electrode of L-type (4) is 0.50-0.75mm, and internal diameter is 0.20-0.30mm.
8. a kind of integrated apparatus recorded for the administration of rat brain area and electroneurographic signal according to claim 1,
Be characterized in that: the distance between the solid symbol electrode (3) and the hollow recording electrode of L-type (4) A are 0.3mm.
9. a kind of integrated apparatus recorded for the administration of rat brain area and electroneurographic signal according to claim 1,
Be characterized in that: the solid symbol electrode (3) is 4- beyond circuit board (2) top distance B with the hollow recording electrode of L-type (4)
6mm。
10. a kind of integrated apparatus recorded for the administration of rat brain area and electroneurographic signal according to claim 1,
Be characterized in that: the diameter of plug is 0.30-0.50mm on the plunger (6).
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