CN215272708U - Cortical electrode for synchronously monitoring drug injection and electrophysiology - Google Patents
Cortical electrode for synchronously monitoring drug injection and electrophysiology Download PDFInfo
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- CN215272708U CN215272708U CN202121581006.4U CN202121581006U CN215272708U CN 215272708 U CN215272708 U CN 215272708U CN 202121581006 U CN202121581006 U CN 202121581006U CN 215272708 U CN215272708 U CN 215272708U
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Abstract
The application relates to a medicine injection and synchronous monitoring cortex electrode of electrophysiology, it includes flexible basement, still including setting up wire and setting on the electroencephalogram conduction piece are connected to electroencephalogram conduction piece, one end on the flexible basement are in injection runner on the flexible basement, electroencephalogram conduction piece are located the flexible basement on the surface, injection runner is including going out the liquid end, goes out the one side that liquid end intercommunication flexible basement was provided with the electroencephalogram conduction piece. The application not only has the function of accurately positioning the focus of the nervous system disease, but also can realize accurate administration of the focus.
Description
Technical Field
The application relates to the field of electrodes for sensing and recording intracranial bioelectric waves, in particular to a cortical electrode for medicament injection and electrophysiological synchronous monitoring.
Background
The human brain continuously emits weak brain electricity, which is an intuitive embodiment of brain activity. By monitoring and studying the brain electricity, the real-time physiological state in the brain can be known.
The nervous system disease or the brain tissue lesion can cause abnormal brain tissue discharge, taking epilepsy as an example, the epilepsy can cause the intense abnormal discharge of the brain as a common and serious nervous system disease, the physician can be helped to determine the type of the disease and the position of the disease occurrence by monitoring the electroencephalogram signals, and valuable information is provided for determining a treatment scheme.
Due to the complexity of nerve activity, monitoring errors easily occur only by means of a single electroencephalogram signal, neurosurgery is irreversible, once the judgment of the cutting position is wrong, the dense functional area of the brain is easily damaged, and irretrievable results are caused. Although drug treatment methods can avoid surgical irreversible results, the drug resistance of the patient and the unintended diffusion of the drug can prevent the drug from acting on the target area and thus the therapeutic effect cannot be achieved. For mild neurological conditions, precise drug therapy is effective, but for refractory neurological conditions, treatment can only be achieved by neurosurgery.
SUMMERY OF THE UTILITY MODEL
The defect that a deep electrode cannot accurately position an intracranial focus area is overcome, and the application provides a cortical electrode for synchronously monitoring drug injection and electrophysiology.
The application provides a medicine injection and synchronous monitoring cortex electrode of electrophysiology adopts following technical scheme:
the utility model provides a medicine injection and synchronous monitoring cortex electrode of electrophysiology, includes the flexible basement, still including setting up brain electricity conduction spare, one end on the flexible basement are connected wire on brain electricity conduction spare and set up injection flow channel on the flexible basement, brain electricity conduction spare is located the surface of flexible basement, injection flow channel includes the liquid outlet end, and the one side that the flexible basement of liquid outlet end intercommunication was provided with brain electricity conduction spare.
Through adopting above-mentioned technical scheme, place intracranial cortex electrode in the encephalic cerebral cortex of patient through surgery on, the brain electricity conduction piece is collected and is conducted the brain electricity condition of patient to do benefit to and monitor the brain electricity condition of patient. After the suspected lesion position is determined through electric signal monitoring, a doctor can connect a medicament injection device to an injection flow channel, corresponding therapeutic medicaments are used for directly administering the medicament to the suspected lesion position of a patient in a partitioned mode through the injection flow channel, and medicament molecules can directly influence severe electroencephalogram activity of a real lesion area, so that the accurate position of the intracranial lesion area is further determined.
Optionally, the electroencephalogram conducting piece is arranged as an injection needle, the injection needle comprises a connecting end and an injection end, the connecting end is communicated with the liquid outlet end of the injection flow channel, and the injection end is located outside the flexible substrate.
By adopting the technical scheme, the injection needle can conduct electroencephalogram, and can also puncture the encephalic blood brain barrier to transport the medicine to the brain parenchyma, so that whether the medicine can not break through the blood brain barrier or not can be not considered, and the medicine molecules are quickly diffused to a target area from an injection point by utilizing a blood circulation system in the brain, so that the treatment efficiency and accuracy are improved.
Optionally, a retaining ring is arranged on the connecting end of the injection needle.
Through adopting above-mentioned technical scheme, keep off the ring card and establish inside flexible basement, can set up the syringe needle stably on flexible basement, in addition, keep off the ring and can also be connected with the wire, under the prerequisite that does not interfere wire and syringe needle conduction brain electricity, can also promote the stability of being connected of wire and syringe needle.
Optionally, the injection end of the injection needle is provided as a tip.
Through adopting above-mentioned technical scheme, the point does benefit to the syringe needle and breaks through the blood brain barrier, promotes the treatment of molecular medicine.
Optionally, the brain electrical conduction element is set as an electrode point.
Optionally, the injection flow channel includes a main flow channel and an auxiliary flow channel with one end communicated with the main flow channel, and the end of the auxiliary flow channel far away from the main flow channel is a liquid outlet end.
Through adopting above-mentioned technical scheme, the sprue is convenient for be connected with external medicine injection equipment, and the auxiliary flow way is convenient for carry the molecule medicine to the focus district to realize accurate dosing, promote treatment.
Optionally, the injection flow channel is opened inside the flexible substrate.
By adopting the technical scheme, the injection flow channel arranged in the flexible substrate can not increase the integral volume of the cortical electrode, and can not influence the joint of the flexible substrate and the intracranial cerebral cortex.
Optionally, an external conduit is connected to the liquid inlet end of the injection flow channel.
Through adopting above-mentioned technical scheme, be connected medicine injection equipment and external catheter, be convenient for communicate medicine injection equipment and injection flow channel to be convenient for carry out the medicine injection.
Optionally, the drug injection and electrophysiological synchronous monitoring electrode is configured as a grid electrode.
Optionally, the drug injection and electrophysiological synchronous monitoring electrode is configured as a strip electrode.
In summary, the present application includes at least one of the following beneficial technical effects:
1. by arranging the electroencephalogram conduction piece, the lead and the injection flow channel, the intracranial direct drug delivery of the patient can be carried out while the electroencephalogram condition of the patient is monitored, so that the accurate position of an intracranial focal zone is further determined, the accurate positioning of the focal can provide reliable guidance for neurosurgery operation for refractory nervous system diseases, and the success rate of the operation is remarkably improved; for mild disease, doctors can continuously administer drugs to the focus of a patient through the micro-channel within the implantable life of the electrode, so as to realize the purpose of direct administration treatment; and the design of electrode synchronous monitoring and direct administration forms a closed-loop monitoring system, which can provide a powerful tool for scientific research personnel to research pathogenesis of nervous system diseases;
2. by arranging the injection needle, the injection needle can conduct electroencephalogram, can also quickly diffuse medicine molecules from an injection point to a target area by utilizing a blood circulation system in the brain without considering whether the medicine can not break through a blood brain barrier or not, and thus the treatment efficiency and accuracy are improved;
3. through setting up the sprue and assisting the runner, the sprue is convenient for be connected with external medicine injection equipment, and it carries the molecule medicine to the focus district to assist the runner to be convenient for, is favorable to the diffusion of medicine, promotes treatment.
Drawings
FIG. 1 is a schematic diagram of the structure of a cortical electrode for simultaneous drug injection and electrophysiological monitoring in example 1;
FIG. 2 is a schematic diagram showing the structure of a cortical electrode for simultaneous drug injection and electrophysiological monitoring in example 2;
FIG. 3 is a schematic cross-sectional view of the monitoring electrode of FIG. 2;
FIG. 4 is an enlarged partial schematic view of portion A of FIG. 3;
FIG. 5 is a schematic diagram showing the structure of a cortical electrode for simultaneous drug injection and electrophysiological monitoring in example 3;
FIG. 6 is a schematic cross-sectional view of the monitoring electrode of FIG. 5;
FIG. 7 is a schematic diagram of the cortical electrode for simultaneous drug injection and electrophysiological monitoring in example 4.
Description of reference numerals:
1. a flexible substrate; 2. an electrode point; 3. a wire; 4. an injection flow channel; 41. a main flow channel; 42. an auxiliary flow channel; 5. connecting a conduit externally; 6. an injection needle; 61. and (4) a baffle ring.
Detailed Description
The present application is described in further detail below with reference to figures 1-7.
Example one
The application discloses a medicine injection and synchronous monitoring cortex electrode of electrophysiology, refer to fig. 1, monitoring electrode includes that be rectangular flexible basement 1, evenly lay the brain electricity conduction piece on flexible basement 1 coplanar, one end connect the wire 3 on brain electricity conduction piece and set up on flexible basement 1 and go out the liquid end and lie in the injection runner 4 on flexible basement 1 coplanar with brain electricity conduction piece.
After the monitoring electrode is placed on the intracranial cerebral cortex of a patient through an operation, the electroencephalogram conducting piece can collect and detect the intracranial electroencephalogram of the patient, a doctor uses medicines for the patient, medicine injection equipment is connected onto an injection flow channel 4, the medicines act on a focus area, the electroencephalogram of the focus area fluctuates, and when the monitoring electrode monitors that abnormal conditions of the intracranial electroencephalogram occur, the intracranial focus area can be accurately determined.
In this embodiment, the flexible substrate 1 is the flexible substrate 1 made of medical silica gel, and the medical silica gel has better flexibility, so that the flexible substrate 1 can be better attached to the cerebral cortex, and the flexible substrate 1 is set to be a rectangular grid.
Referring to fig. 1, in the present embodiment, the electroencephalogram conducting element adopts electrode points 2, the electrode points 2 are arranged in four rows at intervals, and the direction of each row of electrode points 2 is parallel to the length direction of the flexible substrate 1. Every row of electrode point 2 interval is provided with eight, and evenly distributed's a plurality of electrode point 2 can enlarge the region of monitoring electrode pair patient brain monitoring, can also improve the monitoring accuracy nature. The four rows of electrode points 2 form three gaps, and the leads 3 connecting the four rows of electrode points 2 are arranged in the two gaps which are spaced.
The electrode point 2 can be made of platinum-iridium alloy or medical stainless steel, so that the electrode point 2 can meet medical conditions and conduct electroencephalogram.
Referring to fig. 1, injection flow channel 4 has seted up two sets ofly, and two sets of injection flow channel 4 all set up in the space placed in the middle that four rows of electrode points 2 formed, the finite space on the rational utilization flexible substrate 1 to make wire 3 and injection flow channel 4 rational distribution on flexible substrate 1, mutual noninterference promotes the use reliability of monitoring electrode.
The injection flow channel 4 comprises a main flow channel 41 with the length direction parallel to the length direction of the flexible substrate 1 and an auxiliary flow channel 42 with one end communicated with the main flow channel 41, one end of the main flow channel 41 is positioned in the flexible substrate 1, the other end of the main flow channel is communicated with the side surface of the flexible substrate 1, one end of the main flow channel 41 communicated with the side surface of the flexible substrate 1 is set as a liquid inlet end, and the liquid inlet ends of the two main flow channels 41 are positioned on the same side of the flexible substrate 1. The auxiliary flow channels 42 are provided with seven, the seven auxiliary flow channels 42 are positioned at one end of the main flow channel 41 in the flexible substrate 1 and are distributed at intervals along the length direction of the main flow channel 41, and each auxiliary flow channel 42 is respectively positioned at the middle position between two adjacent electrode points 2. The end of the auxiliary flow passage 42 away from the main flow passage 41 is set as a liquid outlet end.
The auxiliary flow channels 42 uniformly distributed among the electrode points 2 can improve the uniformity of the injected molecular drugs and reasonably control the dispersion area of the molecular drugs so as to improve the probability that the drugs directly act on the focus area, thereby improving the treatment effect and determining the accuracy of the focus area.
Referring to fig. 1, the monitoring electrode further includes an external conduit 5 having one end connected to the liquid inlet end of the main channel 41, and a section of the lead 3 away from the electrode point 2 is located on the same side of the flexible substrate 1 as the external conduit 5. When the monitoring electrode is used for medication of a patient, the external medicine injection equipment is conveniently communicated with the main flow channel 41 through the external connecting conduit 5, so that the use convenience of the monitoring electrode is improved.
Example two
The difference between this embodiment and the first embodiment is:
with reference to fig. 2 and 3, the electroencephalogram conducting piece in this embodiment is provided with an injection needle 6, two ends of the injection needle 6 are respectively provided with a connecting end and an injection end, the connecting end is communicated with the liquid outlet end of the auxiliary flow channel 42, and the injection section is located outside the flexible substrate 1. The injection end is processed to form an inclined section and a tip, and the inclined planes of all the injection needles 6 are consistent in orientation and back to the liquid inlet end of the main flow passage 41.
The injection needle 6 can be made of platinum-iridium alloy, medical stainless steel or nickel-chromium alloy, and the size specification of the injection needle 6 can be 1-10mm in length and 0.1-2mm in diameter, so that the injection needle 6 can meet medical conditions and conduct electroencephalogram.
After implanting the patient brain with the monitoring electrode, set up the injection end of syringe needle 6 towards cerebral cortex, syringe needle 6 can enough conduct the brain electricity, and syringe needle 6 can also penetrate cerebral cortex to can not consider whether the medicine exists the defect that can not break through the blood brain barrier, utilize the inside blood circulation system of brain to spread the medicine molecule to the target area by the injection point is fast, with the speed and the accuracy that promote the treatment.
Referring to fig. 3 and 4, a stopper 61 is provided on the connection end of the injection needle 6, the surface of the stopper 61 is perpendicular to the axial direction of the injection needle 6, and the lead 3 is connected to the stopper 61.
The baffle ring 61 is arranged in the flexible substrate 1, so that the installation stability of the injection needle 6 can be effectively improved, and the connection reliability of the connecting end and the liquid outlet end can be improved.
Referring back to fig. 2, in the embodiment, the injection flow channel 4 is provided with four groups corresponding to the four rows of injection needles 6, each group is provided with four injection flow channels 4, each injection flow channel 4 includes a main flow channel 41 and an auxiliary flow channel 42 communicated with the main flow channel 41, liquid inlet ends of the four groups of main flow channels 41 are all communicated with the same side surface of the flexible substrate 1, the other end of the main flow channel 41 is connected to a middle point position of the length of the auxiliary flow channel 42, two ends of the auxiliary flow channel 42 are respectively connected with one injection needle 6, and the liquid inlet end is connected with the external conduit 5.
EXAMPLE III
The difference between this embodiment and the second embodiment is:
referring to fig. 5, in this embodiment, the flexible substrate 1 is set to be a strip, eight flexible substrates 1 of the brain electrical conduction component are arranged at intervals in the length direction, in this embodiment, the brain electrical conduction component adopts electrode points 2, the wires 3 are sequentially connected to the eight electrode points 2, two groups of injection flow channels 4 are arranged, and the two groups of injection flow channels 4 are respectively located on two sides of one row of electrode points 2 in the length direction.
Each set of injection flow channel 4 comprises a main flow channel 41 and an auxiliary flow channel 42 communicated with the main flow channel 41, one end of the main flow channel 41 is positioned in the flexible substrate 1, the other end of the main flow channel is communicated with the side surface of the flexible substrate 1, one end of the main flow channel 41 communicated with the flexible substrate 1 is set to be a liquid inlet end, the liquid inlet ends of the two main flow channels 41 are positioned at the same end of the flexible substrate 1, and one section of the lead 3, which is positioned outside the flexible substrate 1, and the liquid inlet end are positioned at the same end of the flexible substrate 1.
Four auxiliary flow channels 42 are communicated with one main flow channel 41, the four auxiliary flow channels 42 are respectively positioned at the middle point positions of the interval between two adjacent electrode points 2, and the two groups of auxiliary flow channels 42 are sequentially arranged close to the eight electrode points 2. An external conduit 5 is connected to the liquid inlet end of the main channel 41.
Referring to fig. 6, the electrode points 2 are arranged as circular pieces with a protruding middle part, and the cross sections of the electrode points are in a shape of a Chinese character 'tu'. The part protruding from the electrode point 2 body is positioned on the flexible substrate 1, and the part with larger diameter of the electrode point 2 is positioned in the flexible substrate 1.
The convex electrode points 2 can improve the stability of the electrode points 2 installed in the flexible substrate 1, so that the use reliability of the strip-shaped electrodes is improved.
Example four
The difference between this embodiment and the third embodiment is that:
referring to fig. 7, in the present embodiment, the electroencephalogram conducting component is provided as an injection needle 6 (not shown in the figure), the injection flow channels 4 are provided in four groups, each two groups are respectively located at two sides of a row of injection needles 6 in the length direction, the injection flow channels 4 in the present embodiment are the same as the injection flow channels 4 in the second embodiment, and eight injection needles 6 are respectively connected to two ends of the auxiliary flow channel 42.
The above embodiments are preferred embodiments of the present application, and the protection scope of the present application is not limited by the above embodiments, so: all equivalent changes made according to the structure, shape and principle of the present application shall be covered by the protection scope of the present application.
Claims (10)
1. The utility model provides a medicine injection and synchronous monitoring cortex electrode of electrophysiology, includes flexible base (1), its characterized in that: the electroencephalogram conduction piece is arranged on the flexible substrate (1), one end of the wire (3) is connected onto the electroencephalogram conduction piece, the injection flow channel (4) is arranged on the flexible substrate (1), the electroencephalogram conduction piece is located on the surface of the flexible substrate (1), the injection flow channel (4) comprises a liquid outlet end, and the liquid outlet end is communicated with one surface, provided with the electroencephalogram conduction piece, of the flexible substrate (1).
2. The cortical electrode for simultaneous medication injection and electrophysiology monitoring of claim 1, wherein: the electroencephalogram conducting piece is arranged as an injection needle (6), the injection needle (6) comprises a connecting end and an injection end, the connecting end is communicated with the liquid outlet end of the injection flow channel (4), and the injection end is located outside the flexible substrate (1).
3. The cortical electrode for simultaneous medication injection and electrophysiology monitoring of claim 2, wherein: a retaining ring (61) is arranged on the connecting end of the injection needle (6).
4. The cortical electrode for simultaneous medication injection and electrophysiology monitoring of claim 2 or 3, wherein: the injection end of the injection needle (6) is provided with a sharp end.
5. The cortical electrode for simultaneous medication injection and electrophysiology monitoring of claim 1, wherein: the brain electric conduction piece is set as an electrode point (2).
6. The cortical electrode for simultaneous medication injection and electrophysiology monitoring of claim 1, wherein: the injection flow channel (4) comprises a main flow channel (41) and an auxiliary flow channel (42) with one end communicated with the main flow channel (41), and the end, far away from the main flow channel (41), of the auxiliary flow channel (42) is a liquid outlet end.
7. The cortical electrode for simultaneous medication injection and electrophysiology monitoring of claim 6, wherein: the injection flow channel (4) is arranged in the flexible substrate (1).
8. The cortical electrode for simultaneous medication injection and electrophysiology monitoring of claim 7, wherein: the liquid inlet end of the injection flow channel (4) is connected with an external conduit (5).
9. The cortical electrode for simultaneous medication injection and electrophysiology monitoring of claim 1, wherein: the medicine injection and electrophysiological synchronous monitoring electrode is set as a grid electrode.
10. The cortical electrode for simultaneous medication injection and electrophysiology monitoring of claim 1, wherein: the drug injection and electrophysiological synchronous monitoring electrode is arranged as a strip electrode.
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| Application Number | Priority Date | Filing Date | Title |
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| CN202121581006.4U CN215272708U (en) | 2021-07-12 | 2021-07-12 | Cortical electrode for synchronously monitoring drug injection and electrophysiology |
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| Application Number | Priority Date | Filing Date | Title |
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| CN202121581006.4U CN215272708U (en) | 2021-07-12 | 2021-07-12 | Cortical electrode for synchronously monitoring drug injection and electrophysiology |
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| CN215272708U true CN215272708U (en) | 2021-12-24 |
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