CN106361416B - The minimally invasive micro multiple target point injecting systems of intracerebral for stereotaxis navigation equipment - Google Patents
The minimally invasive micro multiple target point injecting systems of intracerebral for stereotaxis navigation equipment Download PDFInfo
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- CN106361416B CN106361416B CN201610851340.4A CN201610851340A CN106361416B CN 106361416 B CN106361416 B CN 106361416B CN 201610851340 A CN201610851340 A CN 201610851340A CN 106361416 B CN106361416 B CN 106361416B
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- 230000033912 thigmotaxis Effects 0.000 title claims abstract description 27
- 239000007924 injection Substances 0.000 claims abstract description 46
- 238000002347 injection Methods 0.000 claims abstract description 46
- 239000007788 liquid Substances 0.000 claims abstract description 30
- 239000002184 metal Substances 0.000 claims abstract description 20
- 229910052751 metal Inorganic materials 0.000 claims abstract description 20
- 238000000520 microinjection Methods 0.000 claims abstract description 8
- 230000000007 visual effect Effects 0.000 abstract description 4
- 230000009286 beneficial effect Effects 0.000 abstract description 2
- 239000003814 drug Substances 0.000 description 18
- 210000004556 brain Anatomy 0.000 description 15
- 229940079593 drug Drugs 0.000 description 13
- 238000000034 method Methods 0.000 description 10
- 230000006378 damage Effects 0.000 description 8
- 210000005013 brain tissue Anatomy 0.000 description 7
- 208000027418 Wounds and injury Diseases 0.000 description 5
- 238000010586 diagram Methods 0.000 description 5
- 208000014674 injury Diseases 0.000 description 5
- 241001448725 Endorchis Species 0.000 description 4
- 238000013461 design Methods 0.000 description 4
- 241001465754 Metazoa Species 0.000 description 3
- 238000005516 engineering process Methods 0.000 description 3
- 239000002504 physiological saline solution Substances 0.000 description 3
- 230000001225 therapeutic effect Effects 0.000 description 3
- 239000003708 ampul Substances 0.000 description 2
- 210000004204 blood vessel Anatomy 0.000 description 2
- 239000006285 cell suspension Substances 0.000 description 2
- 230000002490 cerebral effect Effects 0.000 description 2
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- VYPSYNLAJGMNEJ-UHFFFAOYSA-N silicon dioxide Inorganic materials O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 210000000278 spinal cord Anatomy 0.000 description 2
- 206010002091 Anaesthesia Diseases 0.000 description 1
- 208000014644 Brain disease Diseases 0.000 description 1
- 206010053942 Cerebral haematoma Diseases 0.000 description 1
- 201000005171 Cystadenoma Diseases 0.000 description 1
- 241000699670 Mus sp. Species 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 241000288906 Primates Species 0.000 description 1
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- 229910000831 Steel Inorganic materials 0.000 description 1
- 230000037005 anaesthesia Effects 0.000 description 1
- 238000005452 bending Methods 0.000 description 1
- 239000003124 biologic agent Substances 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
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- 210000003169 central nervous system Anatomy 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000012377 drug delivery Methods 0.000 description 1
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- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 1
- 239000010931 gold Substances 0.000 description 1
- 229910052737 gold Inorganic materials 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 238000009434 installation Methods 0.000 description 1
- 238000007917 intracranial administration Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
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- 210000001178 neural stem cell Anatomy 0.000 description 1
- 230000000149 penetrating effect Effects 0.000 description 1
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods
- A61B17/34—Trocars; Puncturing needles
- A61B17/3478—Endoscopic needles, e.g. for infusion
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods
- A61B17/34—Trocars; Puncturing needles
- A61B17/3403—Needle locating or guiding means
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods
- A61B17/34—Trocars; Puncturing needles
- A61B17/3415—Trocars; Puncturing needles for introducing tubes or catheters, e.g. gastrostomy tubes, drain catheters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods
- A61B17/34—Trocars; Puncturing needles
- A61B17/3472—Trocars; Puncturing needles for bones, e.g. intraosseus injections
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods
- A61B17/34—Trocars; Puncturing needles
- A61B17/3417—Details of tips or shafts, e.g. grooves, expandable, bendable; Multiple coaxial sliding cannulas, e.g. for dilating
- A61B2017/3454—Details of tips
- A61B2017/3456—Details of tips blunt
Landscapes
- Health & Medical Sciences (AREA)
- Surgery (AREA)
- Life Sciences & Earth Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Molecular Biology (AREA)
- Pathology (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Veterinary Medicine (AREA)
- Medical Informatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Gastroenterology & Hepatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
Abstract
The invention discloses a kind of minimally invasive micro multiple target point injecting systems of intracerebral for stereotaxis navigation equipment, including needle core and the housing needle tubing being sheathed on needle core, the front end of the housing needle tubing is provided with injection needle head end sheath, the rear end of housing needle tubing is inserted with connector, the connector rear end is connected with metal connecting piece, the front end of the needle core and the part of housing needle tubing joint are rounded blunt nosed, the rear end of needle core is connected with handpiece, rotatable transparent carrier liquid pipe connections are equipped in the metal connecting piece, the rear end of the transparent carrier liquid pipe connections is connected with the connector being connect with micro-injection pump by transparent carrier liquid pipe.Beneficial effects of the present invention：Has the advantages that minimally invasive, micro, visual controllable, multiple target point stereotactic injection.
Description
Technical field
The present invention relates to technical field of medical equipment more particularly to a kind of intracerebral for stereotaxis navigation equipment are minimally invasive
Micro multiple target point injecting systems.
Background technology
Drug injection to intracerebral local lesion directly can be treated into brain diseases, clinically common usage is using common
Intracerebral puncture needle（Diameter 2-3mm, length 19cm）Radionuclide list target spot is injected to intracerebral with stereotaxis navigation equipment
In cystoma venereal disease becomes, to achieve the purpose that local radiation is treated.Above-mentioned puncture needle pusher is connected using ordinary syringe
Injection product, the volume for injecting drug is often greater than 500ul, and the medicine of this volume is unable in direct injection to brain parenchym, because
Slight occupation time process will be generated for larger volume injected, the Accessory injury except therapeutic effect is caused to brain parenchym, and only
The drug release of single puncture path list target spot can be carried out in brain tissue.
Existing puncture needle can not achieve the minimally invasive, micro of medicine in brain parenchym, multiple target point injection.In addition, patent is examined
Suo Faxian " a kind of visual minimal removed of intracranial drug delivery device "（104225772 A of application publication number CN）Core apparatus be a kind of use
In toy（Rats and mice）The capillary quartz ampoule of experiment（Internal diameter is 0.35mm, outer diameter 0.5mm）.This device cannot match vertical
Body directed navigation equipment, and long quartz ampoule has the risk to fracture in intracerebral, be unsuitable for being applied to the mankind, primate and its
It injects in the brain deep of his larger animal.
Invention content
The object of the present invention is to provide a kind of minimally invasive micro multiple target point injection systems of intracerebral for stereotaxis navigation equipment
System, to overcome the shortcomings of in currently available technology.
To realize the above-mentioned technical purpose, the technical proposal of the invention is realized in this way：
A kind of minimally invasive micro multiple target point injecting systems of intracerebral for stereotaxis navigation equipment, including needle core and be arranged
The front end of housing needle tubing on needle core, the housing needle tubing is provided with injection needle head end sheath, the rear end of housing needle tubing is inserted into
There are connector, the connector rear end to be connected with metal connecting piece, the part of the front end and housing needle tubing joint of the needle core
Rounded blunt nosed, the rear end of needle core is connected with handpiece, and rotatable transparent carrier liquid Guan Lian is equipped in the metal connecting piece
The rear end of fitting, the transparent carrier liquid pipe connections is connected with the connector being connect with micro-injection pump by transparent carrier liquid pipe.
Further, the length of the housing needle tubing is 50-300mm, and the pipe thickness of outer diameter 1mm, housing needle tubing are
0.25mm。
Further, the length of the housing needle tubing is 198mm.
Further, the length of the needle core is 62-312mm, a diameter of 0.4mm.
Further, the length of the needle core is 210mm.
Further, the metal connecting piece includes front end, the rear end being connect with front end and connects with rear end
The length of the block plate connect, the front end is 7mm, external screw thread is provided on front end, the length of the rear end is 9mm, institute
The thickness for stating block plate is 2mm.
Further, the injection needle head end sheath includes the head in cone and the tail portion that is connect with head, institute
The length for stating head is 10mm, and the length of the tail portion is 8mm.
Further, graduation mark is provided on the transparent carrier liquid pipe, the length of transparent carrier liquid pipe is 1000-3000mm.
Further, the internal thread to match with external screw thread is provided on the connector, the length of connector is 15mm.
Beneficial effects of the present invention：Directly reduce the contact area of injection needle and brain tissue, and with high rigidity and straight
Reduce or eliminate rotation inserting needle when caused by brain tissue cutting damage.In piercing process, the injection needle head end of round blunt can have
Effect pushes cerebral blood vessel open, reduces the generation for even avoiding intracerebral hematoma, and minimum injection injection volume can reach 5ul, very well
The intracerebral occupation time process for controlling medicine, pass through the transparent graduated PVC carrier fluids pipe of mark, it is ensured that injection process
Visuality and controllability.Minimally invasive design so that it is same enter cranium point multi-angle puncture be known as may, more targets can be carried out
Point stereotactic injection.To sum up the present invention has the advantages that minimally invasive, micro, visual controllable, multiple target point stereotactic injection.
Description of the drawings
It in order to more clearly explain the embodiment of the invention or the technical proposal in the existing technology, below will be to institute in embodiment
Attached drawing to be used is needed to be briefly described, it should be apparent that, the accompanying drawings in the following description is only some implementations of the present invention
Example, for those of ordinary skill in the art, without creative efforts, can also obtain according to these attached drawings
Obtain other attached drawings.
Fig. 1 is the minimally invasive micro multiple target point note of the intracerebral for stereotaxis navigation equipment described according to embodiments of the present invention
Penetrate the structural schematic diagram of system；
Fig. 2 is the overall structure diagram of the housing needle tubing described according to embodiments of the present invention；
Fig. 3 is the partial enlarged view at A in Fig. 2；
Fig. 4 is the structural schematic diagram of the needle core described according to embodiments of the present invention；
Fig. 5 is the structural schematic diagram of the metal connecting piece described according to embodiments of the present invention；
Fig. 6 is the structural schematic diagram of the stereotaxis navigation equipment fixing piece described according to embodiments of the present invention；
Fig. 7 is Fig. 6 vertical views；
Fig. 8 is the sectional view of Fig. 7.
In figure：
1, housing needle tubing；2, needle core；3, metal connecting piece；4, injection needle head end sheath；5, connector；6, transparent carrier liquid pipe
Connector；7, transparent carrier liquid pipe；8, stereotaxis navigation equipment fixing piece；9, handpiece；10, connector；31, front end；32、
Rear end；33, block plate；81, centre bore.
Specific implementation mode
Following will be combined with the drawings in the embodiments of the present invention, and technical solution in the embodiment of the present invention carries out clear, complete
Site preparation describes, it is clear that described embodiments are only a part of the embodiments of the present invention, instead of all the embodiments.It is based on
Embodiment in the present invention, all other embodiment that those of ordinary skill in the art are obtained belong to what the present invention protected
Range.
As shown in figures 1-8, a kind of intracerebral for stereotaxis navigation equipment according to embodiments of the present invention is minimally invasive
Micro multiple target point injecting systems, including needle core 2 and the housing needle tubing 1 that is sheathed on needle core 2, the front end of the housing needle tubing 1
It is provided with injection needle head end sheath 4, inserted with connector 10,10 rear end of the connector is connected with gold for the rear end of housing needle tubing 1
Belong to connector 3, the part of the front end and 1 joint of housing needle tubing of the needle core 2 is rounded blunt nosed, and the rear end of needle core 2 is connected with
Handpiece 9 is equipped with rotatable transparent carrier liquid pipe connections 6 in the metal connecting piece 3, is harder rubber product,
It is inserted in metal connecting piece 3, by 3 foward dome of metal connecting piece and rear baffle, by metal connecting piece 3 and transparent carrier liquid pipe
Connector 6 links together, and metal connecting piece 3 can rotate, and cannot be detached on the two position, the transparent carrier liquid pipe connections
6 rear end is connected with the connector 5 being connect with micro-injection pump by transparent carrier liquid pipe 7.
The length of the housing needle tubing 1 is 50-300mm, and the pipe thickness of outer diameter 1mm, housing needle tubing 1 are 0.25mm.
Preferably, the length of the housing needle tubing 1 is 198mm.
The length of the needle core 2 is 62-312mm, a diameter of 0.4mm.Preferably, the length of the needle core 2 is 210mm.
The metal connecting piece 3 includes front end 31, the rear end 32 being connect with front end 31 and connects with rear end 32
The length of the block plate 33 connect, the front end 31 is 7mm, and external screw thread, the length of the rear end 32 are provided on front end 31
Thickness for 9mm, the block plate 33 is 2mm.
The injection needle head end sheath 4 includes the head and the tail portion that is connect with head in cone, the head
Length is 10mm, and tip is sharp, can puncture endocranium, the length of the tail portion is 8mm.
Graduation mark is provided on the transparent carrier liquid pipe 7, the length of transparent carrier liquid pipe 7 is 1000-3000mm.
The internal thread to match with external screw thread is provided on the connector 10, the length of connector is 15mm.
In order to facilitate understand the present invention above-mentioned technical proposal, below by way of in specifically used mode to the present invention it is above-mentioned
Technical solution is described in detail.
It using the present apparatus, is needing in advance using the common disposable sterilized injection for having extracted 3-5ml physiological saline in advance
Device is rinsed, and keeps being full of physiological saline in tube chamber, after connector 5 is connected to micro-injection pump；
After the integral device pumpback 5ul air that will be filled with physiological saline, the drug or cell suspension of requirement can be carried out
Loading, the equipment for loading drug or cell suspension is stablized transparent carrier liquid pipe connections 6 by metal connecting piece 3, watertight
The tail end for being fixed on housing needle tubing 1 of envelope.
Operation consent carries out 3DMR scannings to big animal or human central nervous system, and application software carries out preoperative plan target
The setting of point, and it is designed into the bore position of cranium point or the target position of spinal cord；
Conventional big animal or human body, anesthesia, position support, after stereotaxis navigation equipment is installed, according to it is preoperative plan into
Row sphenotresia or spinal lamina are opened；
By the safety of stereotaxis navigation equipment fixing piece 8 it is firm be installed to stereotaxis navigation equipment after, needle core 2 is inserted
Enter in housing needle tubing 1, after 2 stable connection of housing needle tubing 1 and needle core, checks that the head end that the two combines should be seamless round blunt
Housing needle tubing 1 and 2 combination of needle core are slow transitted through stereotaxis navigation equipment fixing piece 8 by state；
Wherein, injection needle is inserted into single or upper and lower 2 fixing pieces and is consolidated by stereotaxis navigation equipment fixing piece 8
Fixed, 81 internal diameter of centre bore of stereotaxis navigation equipment fixing piece 8 is 1+（0.1 mm -0.2mm）, it is fixed to meet Leksell solids
To the fixing piece of frame, designed in ladder sample, each ladder height is 10mm, and the 1st ladder designs for rectangle, facilitates determining base
Line, the 2nd ladder outer diameter meet orientation folder clamping internal diameter；
Before touching endocranium and endorchis, by the knot of the installation of injection needle head end sheath 4 to housing needle tubing 1 and needle core 2
Fit front end, continuation slowly wear out endocranium or endorchis using the sharpening forward ends of injection needle head end sheath 4 forward；
After penetrating endocranium or endorchis, appropriate rollback housing needle tubing 1, needle core 2 and injection needle head end sheath 4 combine
Body removes injection needle head end sheath 4, continues 2 combination of slow rotary sleeve needle tubing 1 and needle core, across the endocranium perforated
Or endorchis, it is inserted into brain tissue or spinal cord, entire inserting needle process, which should be, to be stablized, without vibrating state.
Wherein, metal connecting piece 3, injection needle head end sheath 4, connector 5, transparent carrier liquid pipe connections 6 and transparent carrier liquid
7 five parts of pipe are mounted entirety, and forward metal connector 3 is placed on outside transparent carrier liquid pipe connections 6, and the two opposite can turn
It is dynamic, transparent carrier liquid pipe connections 6 can be stablized by metal connecting piece 3, the tail end for being fixed on housing needle tubing 1 of water-stop；Thoroughly
6 rear water-stop connection transparent carrier liquid pipe 7 of bright carrier fluid pipe connections, 7 rear end of transparent carrier liquid pipe is connected with connector 5, connector 5
Continue to connect micro-injection pump.
According to the demand of injection, the micro-injection of each target spot ＞ 5ul is carried out, recommends the injection ranging from 5- of each target spot
40ul；After the completion of injecting target spot at one, it can realize that the straight line in single needle road is more by changing housing needle tubing 1 in the depth of intracerebral
Target spot is injected；And realize the injection of 3-D Multi-Target point by changing needle track, the needle track quantity of recommendation is 1-5.
The present invention in order to achieve the purpose that it is minimally invasive, reduce puncture path Accessory injury：1）It is required that the diameter of injection needle is smaller,
Diameter range is 1-2 millimeters, this designs the contact area that can reduce injection needle and brain tissue；2）It is higher stainless using hardness
Steel material ensures that the rigidity of injection needle with straight, when being rotated into needle in brain parenchym in this way, can be reduced or eliminated because of note as far as possible
Penetrate brain tissue incised injury caused by the bending of needle；3）The head end of injection needle needs round blunt, can push head end in piercing process open and contact
Cerebral blood vessel.In order to reduce the occupation time process in the brain parenchym that injection volume is brought, the smaller needle internal diameter of design, range
Liquid is promoted at 0.2-0.8 millimeter, and using micro-injection pump, the fixing fabric structure injected every time is in 5-50ul.Because above-mentioned
Expedients, operation will greatly control the Accessory injury of brain tissue, it is same enter cranium point, carry out multi-angle brain deep and wear
Thorn, and the depth for combining adjustment to puncture, realize the injection of 3-D Multi-Target point.Injection needle rear end connects transparent PVC pipeline, pipeline subscript
Scale and number are remembered, in the process real time drug liquid mobility status of injection.
Common drug and biological agent can be achieved in the present invention（Including neural stem cell etc.）In lesion in brain parenchym or
Perilesional direct injection.It relies on existing a variety of stereotaxis and navigates frame apparatus, it can be achieved that accurately in brain parenchym
Target spot is injected.For injection therapeutic medicine in brain parenchym, need to ensure that the surgical procedure of injection therapeutic medicine generates brain parenchym
Minimum Accessory injury.These Accessory injuries include：1）Puncture path damages（Include being said to the Direct perforantes damage and puncture of brain parenchym
Blood）With 2）The occupation time process in brain parenchym that the injection volume of injection point is brought.Drug is injected in multiple target point brain parenchym, it can be direct
Increase the region of drug covering, and under the premise of drug concentration is certain, increases drug dose.Compared with single target spot injection,
Its medication effect significantly will have more Clinical practicability.Medicine needs to lead in the bolus infusion processes into brain parenchym
Visual access is crossed to determine the unobstructed of injection needle.
The foregoing is merely illustrative of the preferred embodiments of the present invention, is not intended to limit the invention, all essences in the present invention
With within principle, any modification, equivalent replacement, improvement and so on should all be included in the protection scope of the present invention god.
Claims (9)
1. a kind of minimally invasive micro multiple target point injecting systems of intracerebral for stereotaxis navigation equipment, including needle core（2）And set
Set on needle core（2）On housing needle tubing（1）, it is characterised in that：The housing needle tubing（1）Front end be provided with injection needle head end shield
Set（4）, housing needle tubing（1）Rear end inserted with connector（10）, the connector（10）Rear end is connected with metal connecting piece
（3）, the needle core（2）Front end and housing needle tubing（1）The part of joint is rounded blunt nosed, needle core（2）Rear end be connected with
Handpiece（9）, the metal connecting piece（3）Inside it is equipped with rotatable transparent carrier liquid pipe connections（6）, the transparent carrier liquid pipe
Connector（6）Rear end pass through transparent carrier liquid pipe（7）It is connected with the connector being connect with micro-injection pump（5）.
2. the minimally invasive micro multiple target point injecting systems of the intracerebral according to claim 1 for stereotaxis navigation equipment,
It is characterized in that：The housing needle tubing（1）Length be 50-300mm, outer diameter 1mm, housing needle tubing（1）Pipe thickness be
0.25mm。
3. the minimally invasive micro multiple target point injecting systems of the intracerebral according to claim 2 for stereotaxis navigation equipment,
It is characterized in that：The housing needle tubing（1）Length be 198mm.
4. the minimally invasive micro multiple target point injecting systems of the intracerebral according to claim 1 for stereotaxis navigation equipment,
It is characterized in that：The needle core（2）Length be 62-312mm, a diameter of 0.4mm.
5. the minimally invasive micro multiple target point injecting systems of the intracerebral according to claim 4 for stereotaxis navigation equipment,
It is characterized in that：The needle core（2）Length be 210mm.
6. the minimally invasive micro multiple target point injecting systems of the intracerebral according to claim 1 for stereotaxis navigation equipment,
It is characterized in that：The metal connecting piece（3）Including front end（31）With front end（31）The rear end of connection（32）And with it is rear
End（32）The block plate of connection（33）, the front end（31）Length be 7mm, front end（31）On be provided with external screw thread, institute
State rear end（32）Length be 9mm, the block plate（33）Thickness be 2mm.
7. the minimally invasive micro multiple target point injecting systems of the intracerebral according to claim 1 for stereotaxis navigation equipment,
It is characterized in that：The injection needle head end sheath（4）The tail portion for including the head in cone and being connect with head, the head
Length be 10mm, the length of the tail portion is 8mm.
8. the minimally invasive micro multiple target point injecting systems of the intracerebral according to claim 1 for stereotaxis navigation equipment,
It is characterized in that：The transparent carrier liquid pipe（7）On be provided with graduation mark, transparent carrier liquid pipe（7）Length be 1000-3000mm.
9. the minimally invasive micro multiple target point injecting systems of the intracerebral according to claim 1 for stereotaxis navigation equipment,
It is characterized in that：The connector（10）On be provided with the internal thread to match with external screw thread, connector（10）Length be 15mm.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610851340.4A CN106361416B (en) | 2016-09-26 | 2016-09-26 | The minimally invasive micro multiple target point injecting systems of intracerebral for stereotaxis navigation equipment |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201610851340.4A CN106361416B (en) | 2016-09-26 | 2016-09-26 | The minimally invasive micro multiple target point injecting systems of intracerebral for stereotaxis navigation equipment |
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| CN106361416A CN106361416A (en) | 2017-02-01 |
| CN106361416B true CN106361416B (en) | 2018-10-19 |
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| CN112494115A (en) * | 2020-11-26 | 2021-03-16 | 北京益华生物科技有限公司 | Brain stereo-orientation medicine moistening device |
| CN114886598A (en) * | 2022-05-11 | 2022-08-12 | 宁夏医科大学 | Laboratory mouse lateral ventricle catheterization device and method |
Citations (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1386552A (en) * | 2002-06-20 | 2002-12-25 | 杨际芝 | Monitoring and therapeutic apparatus for draining and displacing cerebrospinal fluid and pressurizing |
| EP1782850A1 (en) * | 2005-10-31 | 2007-05-09 | Codman & Shurtleff Inc. | Method of removing a stylette from a catheter |
| CN200939268Y (en) * | 2006-06-17 | 2007-08-29 | 秦惠娣 | Externally feeding-medicine transfusion system with low position connecting tube |
| CN201612673U (en) * | 2009-07-20 | 2010-10-27 | 余斌 | Improved peripheral nerve block retaining trocar |
| CN102626337A (en) * | 2012-04-12 | 2012-08-08 | 郑遵成 | Multi-target vertebral canal spinal needle and use method thereof |
| CN202699849U (en) * | 2012-07-27 | 2013-01-30 | 娄世锋 | Injection needle in marrow cavity |
| CN203001074U (en) * | 2012-11-15 | 2013-06-19 | 中国人民解放军北京军区总医院 | Minimally invasive hematoma puncture needle |
| CN104225772A (en) * | 2014-09-25 | 2014-12-24 | 山西医科大学 | Visual minimally-invasive intracranial dosing device |
| CN105013042A (en) * | 2015-07-31 | 2015-11-04 | 中国医科大学附属第一医院 | System for continuously injecting stem cells into minimally-invasive coronary artery blood vessel |
| CN205322383U (en) * | 2016-01-25 | 2016-06-22 | 曹树伟 | Tumour minimal access surgery intervenes treatment needle |
| CN206518584U (en) * | 2016-09-26 | 2017-09-26 | 张广柱 | The minimally invasive micro Mutiple Targets injecting systems of intracerebral for stereotaxis navigation equipment |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6478775B1 (en) * | 2000-10-02 | 2002-11-12 | Genyx Medical Inc. | Device for delivering non-biodegradable bulking composition to a urological site |
| US20070255167A1 (en) * | 2004-03-01 | 2007-11-01 | Wolfe Tory Medical, Inc. | Apparatus for monitoring intra-abdominal pressure |
| US7666177B2 (en) * | 2003-09-15 | 2010-02-23 | James Guest | Method and system for cellular transplantation in the spinal cord |
| EP1773219A2 (en) * | 2004-06-24 | 2007-04-18 | BCU International | Method and medical device for rapid and accurate entry through soft tissue and bone |
| US8690884B2 (en) * | 2005-11-18 | 2014-04-08 | Carefusion 2200, Inc. | Multistate-curvature device and method for delivering a curable material into bone |
-
2016
- 2016-09-26 CN CN201610851340.4A patent/CN106361416B/en active Active
Patent Citations (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1386552A (en) * | 2002-06-20 | 2002-12-25 | 杨际芝 | Monitoring and therapeutic apparatus for draining and displacing cerebrospinal fluid and pressurizing |
| EP1782850A1 (en) * | 2005-10-31 | 2007-05-09 | Codman & Shurtleff Inc. | Method of removing a stylette from a catheter |
| CN200939268Y (en) * | 2006-06-17 | 2007-08-29 | 秦惠娣 | Externally feeding-medicine transfusion system with low position connecting tube |
| CN201612673U (en) * | 2009-07-20 | 2010-10-27 | 余斌 | Improved peripheral nerve block retaining trocar |
| CN102626337A (en) * | 2012-04-12 | 2012-08-08 | 郑遵成 | Multi-target vertebral canal spinal needle and use method thereof |
| CN202699849U (en) * | 2012-07-27 | 2013-01-30 | 娄世锋 | Injection needle in marrow cavity |
| CN203001074U (en) * | 2012-11-15 | 2013-06-19 | 中国人民解放军北京军区总医院 | Minimally invasive hematoma puncture needle |
| CN104225772A (en) * | 2014-09-25 | 2014-12-24 | 山西医科大学 | Visual minimally-invasive intracranial dosing device |
| CN105013042A (en) * | 2015-07-31 | 2015-11-04 | 中国医科大学附属第一医院 | System for continuously injecting stem cells into minimally-invasive coronary artery blood vessel |
| CN205322383U (en) * | 2016-01-25 | 2016-06-22 | 曹树伟 | Tumour minimal access surgery intervenes treatment needle |
| CN206518584U (en) * | 2016-09-26 | 2017-09-26 | 张广柱 | The minimally invasive micro Mutiple Targets injecting systems of intracerebral for stereotaxis navigation equipment |
Non-Patent Citations (1)
| Title |
|---|
| 《神经干细胞多靶点精准脑内移植术》;张广柱，等;《中华神经创伤外科电子杂志》;20160430;第2卷(第2期);第127-128页 * |
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