CN113349738A

CN113349738A - Medicine injection and electrophysiological synchronous monitoring deep electrode

Info

Publication number: CN113349738A
Application number: CN202110786008.5A
Authority: CN
Inventors: 陈晗青; 安小广; 李凯旺
Original assignee: Beijing Hkhs Healthcare Co ltd
Current assignee: Beijing Hkhs Healthcare Co ltd
Priority date: 2021-07-12
Filing date: 2021-07-12
Publication date: 2021-09-07

Abstract

The application relates to a medicine injection and electrophysiological synchronous monitoring deep electrode, which comprises a tube body, a plurality of second electrode points, a plurality of leads and an injection tube, wherein one end of the tube body is a closed end; a lead placing cavity and an injection cavity for a lead to penetrate are formed in the tube body, and the injection tube is communicated with the injection cavity; a plurality of injection holes communicated with the injection cavity are arranged on the tube body. The closed-loop monitoring system formed by medicine injection and electroencephalogram monitoring can realize accurate positioning and accurate administration of the focus of nervous system diseases.

Description

Medicine injection and electrophysiological synchronous monitoring deep electrode

Technical Field

The application relates to the field of electrodes for sensing and recording intracranial bioelectric waves, in particular to a deep electrode for drug injection and electrophysiological synchronous monitoring.

Background

The human brain continuously emits weak brain electricity, which is an intuitive embodiment of brain activity. By monitoring and studying the brain electricity, the real-time physiological state in the brain can be known.

The nervous system disease or the brain tissue lesion can cause abnormal brain tissue discharge, taking epilepsy as an example, the epilepsy can cause the intense abnormal discharge of the brain as a common and serious nervous system disease, the physician can be helped to determine the type of the disease and the position of the disease occurrence by monitoring the electroencephalogram signals, and valuable information is provided for determining a treatment scheme.

Due to the complexity of nerve activity, monitoring errors easily occur only by means of a single electroencephalogram signal, neurosurgery is irreversible, once the judgment of the cutting position is wrong, the dense functional area of the brain is easily damaged, and irretrievable results are caused. Although drug treatment methods can avoid surgical irreversible results, the drug resistance of the patient and the unintended diffusion of the drug can prevent the drug from acting on the target area and thus the therapeutic effect cannot be achieved. Also, for mild neurological diseases, precise medication is effective, while for intractable neurological diseases, treatment can only be performed by neurosurgery.

Disclosure of Invention

In order to overcome the defect that a deep electrode cannot accurately position an intracranial focus area, the application provides a medicament injection and electrophysiological synchronous monitoring electrode.

The application provides a medicine injection and synchronous monitoring deep electrode of electrophysiology adopts following technical scheme:

a medicine injection and electrophysiological synchronous monitoring deep electrode comprises a tube body, a plurality of second electrode points, a plurality of leads and an injection tube, wherein one end of the tube body is a closed end;

a lead placing cavity and an injection cavity for a lead to penetrate are formed in the tube body, and the injection tube is communicated with the injection cavity;

a plurality of injection holes communicated with the injection cavity are arranged on the tube body.

By adopting the technical scheme, the monitoring electrode is arranged in the deep part of the brain in a brain surgery or a stereotactic mode, when the second electrode point preliminarily monitors the electroencephalogram, the hollow structural characteristics of the tube body are utilized, external medicine injection equipment is connected to the injection tube, molecular medicines enter the tube body through the injection tube and are finally discharged to the area with intracranial dysfunction and an epileptogenic focus through the injection hole, when the molecular medicines act on the area with intracranial dysfunction and the epileptogenic focus, the electroencephalogram at the corresponding intracranial part fluctuates, so that doctors can further determine the focal zone, a plurality of novel deep electrodes are used, a three-dimensional monitoring area can be formed in the cranium of a patient, and the intracranial deep monitoring area can be further determined while the intracranial electrode is formed. In addition, the device can provide real-time data of brain electricity change before and after drug administration on scientific research work, reflects the effect of drug treatment, is beneficial to scientific researchers to know complex neural activity, and helps the scientific researchers to research nervous system diseases.

Optionally, the second electrode point is in an annular shape adapted to the tube body, and the second electrode point is sleeved on the tube body.

Through adopting above-mentioned technical scheme, second electrode point simple structure when being convenient for make, still does benefit to and installs second electrode point stable mounting on the body.

Optionally, install first electrode point on the closed end of body, the both ends of first electrode point are open end and blind end respectively, and open end cover is established on the body, and the blind end sets up to the sphere.

By adopting the technical scheme, the first electrode point can increase the intracranial electroencephalogram monitoring area of the patient, and the closed end of the spherical surface of the first electrode point is favorable for inserting the monitoring electrode into the brain tissue of the patient.

Optionally, the other end of the tube body is an open end, a fixing cap is mounted on the open end of the tube body, and one end of the injection tube is connected with the fixing cap.

Through adopting above-mentioned technical scheme, the locking cap can seal the tip of body, can also be convenient for connect the injection syringe on the body.

Optionally, a plug for plugging with the fixing cap is mounted on one end of the injection tube.

Through adopting above-mentioned technical scheme, use the plug to be convenient for be connected injection tube and locking cap.

Optionally, a connector is mounted at the other end of the syringe.

Through adopting above-mentioned technical scheme, the connector is convenient for be connected injection syringe and external medicine injection apparatus.

Optionally, a wire conduit for a wire to pass through is installed on the fixing cap.

Through adopting above-mentioned technical scheme, the wire for with the intraductal many wires of doing benefit to rationally accomodate to promote monitoring electrode's use reliability.

Optionally, a plug connector is connected to one end of the wire far away from the second electrode point.

By adopting the technical scheme, the plug connector is convenient for electrically connecting the lead with the external computer system.

Optionally, a plurality of injection holes are formed on the circumferential surface of the closed end of the tube body;

the injection tube is arranged in the tube body, one end of the injection tube is arranged at an interval with the inside of the closed end of the tube body, and the other end of the injection tube is communicated with the injection tube.

By adopting the technical scheme, the monitoring electrode is inserted into the intracranial, the medicine is directly applied to the suspected lesion position of the patient in a partitioned mode, the medicine can gradually flow into the intracranial space when the medicine extends into the intracranial space along with the monitoring electrode, the diffusion space of the medicine is effectively improved, and meanwhile the monitoring range of the electrode point to the lesion area can be further improved, so that the accuracy of determining the lesion area is improved.

Optionally, a blocking piece for covering the injection hole is fixedly connected to the outer wall of the tube body, and the blocking piece is made of medical plastics.

By adopting the technical scheme, when the pipe body is inserted into the cranium, the injection hole is in a closed state under the covering of the baffle plate, so that the intracranial substances can be effectively prevented from entering the injection cavity through the injection hole, the possibility that the injection hole is blocked by the intracranial substances is effectively reduced, and the baffle plate has good elasticity and flexibility and cannot interfere the injection of the medicine into the cranium.

In summary, the present application includes at least one of the following beneficial technical effects:

1. by arranging the tube body, the second electrode point, the lead and the injection tube, when the second electrode point monitors the electroencephalogram, molecular drugs enter the tube body through the injection tube and are finally discharged to an intracranial dysfunctional region and an epileptogenic focus through the injection hole, so that doctors can further determine a focal region, real-time data of electroencephalogram change before and after administration can be provided, the effect of drug treatment is reflected, researchers can know complex nervous activities, and the researchers can be helped to study nervous system diseases;

2. the second electrode point is arranged in an annular shape, so that the manufacturing is facilitated, and meanwhile, the second electrode point is favorably and stably arranged on the tube body;

3. through setting up first electrode point, first electrode point can increase when to the intracranial brain electricity monitoring area of patient, and the blind end of its sphere still does benefit to and inserts the monitoring electrode in patient's the brain tissue.

Drawings

FIG. 1 is a schematic diagram of a deep electrode for simultaneous drug injection and electrophysiological monitoring in accordance with an embodiment;

FIG. 2 is a schematic cross-sectional view of a drug injection and electrophysiological monitoring deep electrode;

FIG. 3 is an enlarged partial schematic view of portion A of FIG. 2;

FIG. 4 is a schematic diagram of the structure of a deep electrode for simultaneous drug injection and electrophysiological monitoring in accordance with the second embodiment;

FIG. 5 is an enlarged partial view of portion B of FIG. 4;

FIG. 6 is a schematic cross-sectional view of a deep electrode for simultaneous drug injection and electrophysiological monitoring in accordance with a second embodiment;

FIG. 7 is an enlarged partial schematic view of portion C of FIG. 6;

FIG. 8 is a schematic cross-sectional view of a drug injection and electrophysiological monitoring deep electrode of the present embodiment;

fig. 9 is a partially enlarged schematic view of a portion D in fig. 8.

Description of reference numerals: 1. a pipe body; 11. a wire placement cavity; 12. an injection cavity; 13. an injection hole; 14. a baffle plate; 141. a connecting section; 142. a shielding section; 15. a fixing plate; 2. a fixing cap; 3. an electrode point; 31. a first electrode point; 32. a second electrode point; 4. a conduit; 5. a plug-in unit; 6. a wire; 7. an injection tube; 8. a plug; 9. a connector; 10. a medicine injection tube.

Detailed Description

The present application is described in further detail below with reference to figures 1-9.

Example one

The application discloses medicine injection and synchronous monitoring deep electrode of electrophysiology refer to figure 1, including body 1 that one end set up to the blind end, set up solid fixed cap 2 on the body 1 other end, set up electric pole 3 on the body 1 outer peripheral face, and one end connect on solid fixed cap 2 and with the injection pipe 7 of body 1 inside intercommunication.

Referring to fig. 2, an interlayer is provided in the tube body 1, the interlayer separates the interior of the tube body 1 into a wire placing cavity 11 and an injection cavity 12 for injecting molecular drugs, a wire 6 electrically connected with an electrode point 3 is placed in the wire placing cavity 11, one end of the wire 6 is connected with the electrode point 3, the other end of the wire penetrates through the fixing cap 2 and is located outside the tube body 1, and the fixing cap 2 can seal the wire placing cavity 11.

Referring to fig. 2 and 3, a plurality of injection holes 13 communicating with the injection cavity 12 are further formed in the tube body 1, and the plurality of injection holes 13 are arranged at intervals along the length direction of the tube body 1.

Referring to fig. 1 and 2, the electrode points 3 include a first electrode point 31 and six second electrode points 32 installed on the closed end of the tube body 1, the first electrode point 31 is in a cap structure, two ends of the first electrode point 31 are respectively provided with a closed end and an open end, the inner diameter of the open end of the first electrode point 31 is consistent with the outer diameter of the tube body 1, and the open end of the first electrode point 31 is sleeved on the closed end of the tube body 1. The closed end of the first electrode point 31 is arranged as a sphere to facilitate the insertion of the tube body 1 in the brain tissue of the patient.

The plurality of injection holes 13 are respectively located between the first electrode point 31 and the second electrode point 32 adjacent to the first electrode point 31 and between two adjacent second electrode points 32.

Combine figure 1, fig. 2, still install the conduit 4 that is used for accomodating wire 6 on the locking cap 2, the one end fixed connection of conduit 4 is on locking cap 2, wire 6 wears to establish in conduit 4, wear to establish at wire 6 and serve at conduit 4 and install plug connector 5, plug connector 5 is made by conducting material, be convenient for carry out the electricity with wire 6 and external brain machine system through plug connector 5 and be connected to make electrode point 3 can monitor intracranial brain electricity.

With reference to fig. 1 and 2, a plug 8 and a connector 9 for connecting with the fixing cap 2 are respectively installed at two ends of the injection tube 7, the outer diameter of the plug 8 is gradually reduced from one end to the other end, the injection tube 7 is connected to the end with the larger diameter of the plug 8, a jack matched with the plug 8 is formed in the fixing cap 2, and the end with the smaller diameter of the plug 8 can be inserted into the jack. The connector 9 is convenient for be connected injection tube 7 with external medicine injection equipment to promote the monitoring electrode to carry out the convenience when medication to the patient.

Example two

The difference between this embodiment and the first embodiment is:

referring to fig. 4 and 5, a blocking piece 14 for blocking the injection hole 13 is fixedly connected to the tube body 1, the blocking piece 14 is made of medical plastics, and the blocking piece 14 has good flexibility and elasticity.

Referring to fig. 5, the blocking sheet 14 includes the linkage segment 141 of rigid coupling on the outer wall of the tube body 1 and the shielding segment 142 with linkage segment 141 integrated into one piece, the linkage segment 141 sets up towards the closed end of the tube body 1, the shielding segment 142 is an arc-shaped plate matched with the outer wall of the tube body 1, and the shielding segment 142 covers the injection hole 13, so as to seal the injection hole 13, the shielding segment 142 made of medical plastics can be stably attached to the outer wall of the tube body 1, and the sealing performance of the shielding segment 142 is improved.

With reference to fig. 6 and 7, when the tube body 1 is inserted into the cranium, the injection hole 13 is in a closed state under the cover of the shielding section 142, so that the intracranial substances can be effectively prevented from entering the injection cavity 12 through the injection hole 13, and the possibility that the injection hole 13 is blocked by the intracranial substances is effectively reduced. When the medicine flows out through the injection hole 13 through the injection cavity 12, the shielding section 142 is flushed away from the outer wall of the tube body 1 under the action of the medicine so as to flow out the medicine, and the use reliability of the monitoring electrode is improved.

Referring to fig. 5, the side edges of the connecting section 141 and the shielding section 142 are processed into arc-shaped surfaces, so that when the monitoring electrode is inserted into the cranium, the arc-shaped side surfaces on the blocking pieces 14 can effectively reduce the blocking of intracranial substances, and the insertion of the tube body 1 into the cranium is facilitated.

EXAMPLE III

The difference between this embodiment and the second embodiment is:

referring to fig. 8 and 9, a fixing plate 15 adapted to the tube body 1 is fixedly installed inside the tube body 1, the closed end of the tube body 1 is processed into a spherical surface, and a plurality of injection holes 13 are formed in a section of the tube body 1 near the spherical surface along the circumferential direction of the tube body 1.

The deep electrode for medicine injection and electrophysiological synchronous monitoring further comprises a medicine injection tube 10 installed in the tube body 1, an injection cavity 12 is formed in the medicine injection tube 10, and a wire placing cavity 11 is formed in a cavity between the medicine injection tube 10 and the tube body 1. The lead 6 is disposed in the lead placing cavity 11. Set up the through-hole that supplies injection tube 10 to pass on fixed plate 15, injection tube 10 wears to establish on the through-hole and with fixed plate 15 fixed connection, and injection tube 10 passes the one end of fixed plate 15 and the blind end interval setting of body 1, and the other end and the looks butt of locking cap 2 of injection tube 10, and injection tube 10 can be linked together with injection syringe 7.

When the device is used, firstly, the medicament injection equipment is connected to the injection tube 7, then the monitoring electrode is inserted into the intracranial, the medicament is directly applied to the suspected lesion position of a patient in a subarea mode, the medicament can gradually flow into the intracranial space when extending into the intracranial space along with the monitoring electrode, the monitoring range of the electrode point 3 on the lesion area can be improved while the diffusion space of the medicament is effectively improved, and the accuracy of determining the lesion area is improved.

Example four

The difference between this embodiment and the third embodiment is that:

the blocking piece 14 is connected to the tube body 1, the connecting section 141 is fixedly connected to the outer wall of the tube body 1, the connecting section 141 faces the spherical end of the tube body 1, and the shielding section 142 can cover the injection hole 13.

The above embodiments are preferred embodiments of the present application, and the protection scope of the present application is not limited by the above embodiments, so: all equivalent changes made according to the structure, shape and principle of the present application shall be covered by the protection scope of the present application.

Claims

1. A medicine injection and electrophysiological synchronous monitoring deep electrode is characterized in that: the device comprises a tube body (1) with one end being a closed end, a plurality of second electrode points (32) arranged on the tube body (1) at intervals along the length direction of the tube body (1), a plurality of leads (6) arranged in the tube body (1) and used for being electrically connected with the second electrode points (32), and an injection tube (7) with one end communicated with the other end of the tube body (1);

a lead placing cavity (11) for a lead (6) to penetrate through and an injection cavity (12) are formed in the tube body (1), and the injection tube (7) is communicated with the injection cavity (12);

a plurality of injection holes (13) communicated with the injection cavity (12) are formed in the tube body (1).

2. The deep electrode for simultaneous drug injection and electrophysiological monitoring of claim 1, wherein: the second electrode point (32) is in an annular shape matched with the tube body (1), and the tube body (1) is sleeved with the second electrode point (32).

3. The deep electrode for simultaneous drug injection and electrophysiological monitoring of claim 1, wherein: install first electrode point (31) on the closed end of body (1), the both ends of first electrode point (31) are open end and blind end respectively, and open end cover is established on body (1), and the blind end sets up to the sphere.

4. The deep electrode for simultaneous drug injection and electrophysiological monitoring of claim 3, wherein: the other end of the tube body (1) is an open end, a fixing cap (2) is installed on the open end of the tube body (1), and one end of the injection tube (7) is connected with the fixing cap (2).

5. The deep electrode for simultaneous drug injection and electrophysiological monitoring of claim 4, wherein: a plug (8) which is used for being plugged with the fixed cap (2) is arranged at one end of the injection tube (7).

6. The deep electrode for simultaneous drug injection and electrophysiological monitoring of claim 5, wherein: and the other end of the injection tube (7) is provided with a connector (9).

7. The deep electrode for simultaneous drug injection and electrophysiological monitoring of claim 4, wherein: and the fixing cap (2) is provided with a conduit (4) for a lead (6) to penetrate.

8. The deep electrode for simultaneous drug injection and electrophysiological monitoring of claim 1, wherein: and a plug connector (5) is connected to one end of the lead (6) far away from the second electrode point (32).

9. The deep electrode for simultaneous drug injection and electrophysiological monitoring of claim 1, wherein: a plurality of injection holes (13) are formed in the circumferential surface of the closed end of the tube body (1);

a medicine injection tube (10) is arranged in the tube body (1), one end of the medicine injection tube (10) is arranged at an interval with the inside of the closed end of the tube body (1), and the other end of the medicine injection tube (10) is communicated with the injection tube (7).

10. The deep electrode for simultaneous drug injection and electrophysiological monitoring of claim 1 or 9, wherein: a baffle (14) used for covering the injection hole (13) is fixedly connected to the outer wall of the tube body (1), and the baffle (14) is made of medical plastics.