CN114469115B - Integrated propelling electrode driver - Google Patents

Integrated propelling electrode driver Download PDF

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Publication number
CN114469115B
CN114469115B CN202111528246.2A CN202111528246A CN114469115B CN 114469115 B CN114469115 B CN 114469115B CN 202111528246 A CN202111528246 A CN 202111528246A CN 114469115 B CN114469115 B CN 114469115B
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screw
arms
nut
integrated
supporting
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CN114469115A (en
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徐苏芮
张曦昊
王振
詹阳
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Shenzhen Institute of Advanced Technology of CAS
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Shenzhen Institute of Advanced Technology of CAS
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/24Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
    • A61B5/25Bioelectric electrodes therefor
    • A61B5/279Bioelectric electrodes therefor specially adapted for particular uses
    • A61B5/291Bioelectric electrodes therefor specially adapted for particular uses for electroencephalography [EEG]
    • A61B5/293Invasive
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/24Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
    • A61B5/30Input circuits therefor
    • A61B5/307Input circuits therefor specially adapted for particular uses
    • A61B5/31Input circuits therefor specially adapted for particular uses for electroencephalography [EEG]

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medical Informatics (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Electrotherapy Devices (AREA)
  • Measuring Leads Or Probes (AREA)

Abstract

The invention relates to an integrated push-type electrode driver, which comprises a supporting part, a screw driver and a bottom bracket, wherein the screw driver is arranged on the supporting part; the support part comprises two support arms and adhesion arms, the two support arms are oppositely arranged, and the adhesion arms are positioned between the two support arms and are respectively connected with the rear sides of the two support arms; the screw driver is positioned on the upper sides of the two supporting arms and is respectively connected with the two supporting arms; the bottom bracket is positioned at the lower sides of the two supporting arms and is respectively connected with the two supporting arms; the screw driver is positioned on the upper sides of the two supporting arms and is respectively connected with the two supporting arms; the screw driver is provided with an iron column hole, a silicon tube hole and a screw hole, and the bottom bracket has the same structure as the screw driver. The invention provides an integrated push-type electrode driver, which simplifies parts and a manufacturing method for manufacturing an electrode bracket, and enables a three-dimensional positioning embedded electrode to be more accurate.

Description

Integrated propelling electrode driver
Technical Field
The invention belongs to the technical field of neuroelectrophysiology experiments, and relates to an integrated propelling electrode driver.
Background
In the cognitive activity process of awake animals, the activity rule of each relevant brain region neuron of the brain and the interaction relation of the activity of the relevant brain region neuron are important research fields of the front edge of neuroscience in recent years. Multichannel carrier recording technology is also increasingly receiving attention from researchers as a method of detecting neuronal activity.
As a main technical means of neurophysiology, the manufacture of the electrode has high requirements on hardware, and the operation steps are complex, including four-electrode manufacture, motor driver manufacture, assembly of an electrode cap, electrode gold plating and the like. Wherein the fabrication of the electrode drive affects the accuracy of the implantation of the electrode into the brain region. The traditional electrode manufacturing is to sequentially penetrate the copper columns and the screws into corresponding holes on the PCB in the manufacturing process by assembling the PCB, the screws, the square copper columns and the like to serve as electrode driving devices, after the position is adjusted, epoxy resin is coated on each contact point of the copper columns and the PCB, and the positions coated with the epoxy resin are heated by a hot air gun so as to promote hardening of the epoxy resin. Since the electrodes are to be implanted precisely in the brain region of the mice, the assembled PCB boards are required to be relatively parallel. And the uppermost plate is tightly propped against the head of the screw so as to prevent the electrode wire from shaking up and down. However, the support plates assembled by the scattered plates are often not parallel, so that the screws and the electrode wires are inclined to different degrees due to the misalignment of the positions of the holes. The board can be blown askew by the wind force in the process of heating the glue by using the hot air gun, and the epoxy resin can be blown onto the screw, so that the screw is stuck on the PCB board and cannot step. The operation process is also relatively complex and fine.
Disclosure of Invention
In order to overcome the problems in the prior art, the invention provides an integrated push-type electrode driver, which simplifies parts and a manufacturing method for manufacturing an electrode bracket and enables a three-dimensional positioning embedded electrode to be more accurate.
The technical scheme for solving the problems is as follows: an integrated push-type electrode driver is characterized in that:
comprises a supporting part, a screw driver and a bottom bracket;
the support part comprises two support arms and adhesion arms, the two support arms are oppositely arranged, and the adhesion arms are positioned between the two support arms and are respectively connected with the rear sides of the two support arms; the screw driver is positioned on the upper sides of the two supporting arms and is respectively connected with the two supporting arms;
the bottom bracket is positioned at the lower sides of the two supporting arms and is respectively connected with the two supporting arms;
the screw driver is positioned on the upper sides of the two supporting arms and is respectively connected with the two supporting arms;
the screw driver is provided with an iron column hole, a silicon tube hole and a screw hole, and the bottom bracket has the same structure as the screw driver.
Preferably, the supporting arm and the adhesion arm are both plate-shaped structures.
Preferably, the diameter of the silicon tube hole is 0.7mm.
Preferably, the diameter of the screw hole is 1.4mm.
Preferably, the diameter of the iron pillar hole is 0.6mm.
Preferably, the center distance between the silicon tube hole and the screw hole is 1.7mm.
Preferably, the distance from the center of the screw hole to the supporting arm and the adhesion arm is 1.25mm.
Preferably, the support portion, screw drive and bottom bracket are of unitary construction.
Preferably, the material of the support part, the screw driver and the bottom bracket is photosensitive resin.
Preferably, the support part, the screw driver and the bottom bracket are formed by 3D printing.
The invention has the advantages that:
(1) Precision is reliable: the electrode provided by the invention has the advantages that errors caused by manual manufacturing are avoided, so that hole pairs on the top surface and the bottom surface are aligned, experimental errors are reduced, even if the structure is very stable by printing through photosensitive resin, shaking and fracture can not occur, and the adhesion arm can be well contacted with a connector and is firmer;
(2) The volume is small: the length of the existing propelling point electrode is about 13.1mm, the width is 10mm, and the height is 8mm, while the length of the propelling point electrode is 7mm, the width is less than 7mm, the height is about 5mm, the smaller volume reduces the burden on the head of a mouse, and the experiment is more accurate;
(3) The cost is low: the variety of the used materials is few, the manufacturing cost is reduced, and the requirement on the materials is low;
(4) Easy manufacture: the structure is simple, the device can be used immediately without assembling a bracket, and a complex and fine operation process is avoided;
(5) Time is saved: the time for manufacturing the electrode driver is saved.
Drawings
FIG. 1 is a schematic diagram of an integrated pusher electrode driver according to the present invention;
FIG. 2 is a top view of an integrated pusher electrode driver according to the present invention;
FIG. 3 is a schematic bottom view of an integrated pusher electrode driver according to the present invention;
fig. 4 is a rear side view of an integrated pusher electrode driver according to the present invention.
Wherein: 1. screw drive, 2, iron pillar holes, 3, silicon pipe holes, 4, screw holes, 5, supporting arms, 6, adhesion arms, 7 and a bottom bracket.
Detailed Description
For the purpose of making the objects, technical solutions and advantages of the embodiments of the present invention more apparent, the technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings in the embodiments of the present invention, and it is apparent that the described embodiments are some embodiments of the present invention, but not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the present invention without making any inventive effort, are intended to fall within the scope of the present invention. Thus, the following detailed description of the embodiments of the invention, as presented in the figures, is not intended to limit the scope of the invention, as claimed, but is merely representative of selected embodiments of the invention.
Referring to fig. 1-4, an integrated, pusher-type electrode driver comprises a support portion, a screw drive 1 and a bottom bracket 7; the support part comprises two support arms and adhesion arms, the two support arms are oppositely arranged, and the adhesion arms are positioned between the two support arms and are respectively connected with the rear sides of the two support arms; the screw driver 1 is positioned on the upper sides of the two supporting arms and is respectively connected with the two supporting arms; the bottom bracket 7 is positioned at the lower sides of the two supporting arms and is respectively connected with the two supporting arms; the screw driver 1 is positioned on the upper sides of the two supporting arms and is respectively connected with the two supporting arms; the screw driver 1 is provided with an iron column hole 2, a silicon tube hole 3 and a screw hole 4, and the bottom bracket 7 has the same structure as the screw driver 1.
As a preferred embodiment of the present invention, the support arm and the adhesion arm are each plate-like structures.
As a preferred embodiment of the present invention, the support part, the screw driver 1 and the bottom bracket 7 are of an integral structure.
As a preferred embodiment of the present invention, the material of the support part, the screw driver 1 and the bottom bracket 7 is a photosensitive resin.
As a preferred embodiment of the present invention, the support part, screw driver 1 and bottom bracket 7 are 3D printed.
As a preferred embodiment of the invention, the diameter of the silicon tube hole 3 is 0.7mm.
As a preferred embodiment of the present invention, the screw hole 4 has a diameter of 1.4mm.
As a preferred embodiment of the present invention, the diameter of the iron pillar hole 2 is 0.6mm.
As a preferred embodiment of the present invention, the center distance between the silicon tube hole 3 and the screw hole 4 is 1.7mm.
As a preferred embodiment of the invention, the distance from the center of the screw hole 4 to the supporting arm 5 and the adhesion arm 6 is 1.25mm.
Examples
Referring to fig. 1 to 4, the present invention relates to an integrated propelling electrode driver, which is approximately of a cuboid structure, hollow inside, and support arms 5 on two sides and an adhesion arm 6 on the rear side form a support part; the top is a screw driving part, and the bottom is a bottom bracket 7. The integrated propelling electrode driver is formed by 3D printing by using photosensitive resin.
The support arm 5 serves as a support. The adhesive arm 6 connects the two support arms 5. In addition, the supporting arm 5 and the adhesion arm 6 also play a role of fixing the nut, so that the nut cannot rotate along with the screw, and the stepping purpose is realized. The adhesive arm 6 is used for adhering the connector.
The screw driver 1 and the bottom bracket 7 have the same structure, and the screw driver 1 is provided with an iron column hole 2, a silicon tube hole 3 and a screw hole 4. The iron column hole 2, the silicon tube hole 3 and the screw hole 4 are respectively used for fixing the iron column, the silicon tube and the screw, and the top surface and the bottom surface are respectively provided. The diameter of the iron pillar hole 2 is 0.6mm, the diameter of the silicon tube hole 3 is 0.7mm, and the diameter of the screw hole 4 is 1.4mm. The center distance between the silicon tube hole 3 and the screw hole 4 is 1.7mm. The distance from the center of the screw hole 4 to the supporting arm 5 or the adhesion arm 6 is 1.25mm. The bottom support 7 can be more easily connected with dental cement during electrode implantation to stabilize the fixed electrode.
When in use, the positions of the iron column holes 2 and the silicon tube holes 3 are determined according to the target brain region. Printing or customizing the stent. Firstly, a screw of M1.4 is inserted into the screw hole 4 on the top surface, a hexagonal nut is put in and is inserted through, the position of the nut is adjusted, and one surface of the nut is propped against the supporting arm 5 or the adhesion arm 6. The screw continues to pass through the screw hole 4 on the bottom surface, and a nut is added to enable the screw to pass through. And the position of the last second nut is adjusted, so that the screw head and the second nut are tightly clamped on the top surface and the bottom surface of the bracket, and the second nut is welded on the screw by an electric iron and cannot be loosened or tightened along with the rotation of the nut. The first nut is positioned between the top and bottom surfaces. And secondly, inserting a cluster of 8-9 silicon tubes into the silicon tube hole 3. And (3) adjusting the position of the silicon tube to enable the exposed lengths of the two ends to be approximately the same, and then adhering the silicon tube on one edge of the hexagonal nut by using 502 glue and AB glue successively. It is tested whether the silicon tube can move up and down with the nut. The iron column is put into the iron column hole 2 and is stuck and fixed by epoxy resin. Finally, the joint is stuck on the sticking arm by using 502 glue and AB glue in sequence, and the subsequent operation can be carried out.
In the invention, the position of the screw hole 4 can be adjusted according to the brain region, but the distance between the center of the screw hole 4 and the supporting wall 5 or the adhesion wall 6 is 1.25mm.
Further, in the present invention, the diameter of the silicon tube hole 3 may be adjusted according to the number of electrodes used.
Further, in the present invention, the position of the silicon tube hole 3 is changed according to the position of the screw hole 4.
The foregoing description is only exemplary embodiments of the present invention, and is not intended to limit the scope of the present invention, and all equivalent structures or equivalent processes using the descriptions and the drawings of the present invention, or direct or indirect application in other related system fields are included in the scope of the present invention.

Claims (10)

1. An integrated, pusher-type electrode driver, characterized by:
comprises a supporting part, a screw driver (1) and a bottom bracket (7);
the support part comprises two support arms and adhesion arms, the two support arms are oppositely arranged, and the adhesion arms are positioned between the two support arms and are respectively connected with the rear sides of the two support arms; the screw driver (1) is positioned on the upper sides of the two supporting arms and is respectively connected with the two supporting arms;
the bottom bracket (7) is positioned at the lower sides of the two supporting arms and is respectively connected with the two supporting arms;
the screw driver (1) is positioned on the upper sides of the two supporting arms and is respectively connected with the two supporting arms;
an iron column hole (2), a silicon tube hole (3) and a screw hole (4) are formed in the screw driver (1), and the bottom bracket (7) has the same structure as the screw driver (1);
determining the positions of iron column holes (2) and silicon tube holes (3) according to a target brain region, and printing or customizing a bracket; firstly, penetrating a screw of M1.4 into a screw hole (4) on the top surface, putting a hexagonal nut and enabling the screw to penetrate, adjusting the position of the nut, enabling one surface of the nut to prop against a supporting arm (5) or an adhesion arm (6), enabling the screw to continuously penetrate through the screw hole (4) on the bottom surface, adding a nut, enabling the screw to penetrate through, adjusting the position of a final second nut, enabling a screw head and the second nut to be tightly clamped on the top surface and the bottom surface of a bracket, welding the second nut on the screw by an electric soldering iron, loosening or tightening along with the rotation of the nut, and adjusting the position of the first nut to enable the first nut to be between the top surface and the bottom surface; inserting a cluster of 8-9 silicon tubes into the silicon tube holes (3), adjusting the positions of the silicon tubes to enable the two ends to be exposed to be as long as possible, then adhering the silicon tubes on one edge of the hexagonal nut by using 502 glue and AB glue successively, testing whether the silicon tubes can move up and down along with the nut, loading iron columns into the iron column holes (2), and adhering and fixing the iron columns by using epoxy resin; and finally, sequentially using 502 glue and AB glue to adhere the connector to the adhesion arm.
2. An integrated, pusher electrode driver according to claim 1, wherein:
the supporting arm and the adhesion arm are both plate-shaped structures.
3. An integrated, pusher electrode driver according to claim 2, wherein:
the diameter of the silicon tube hole (3) is 0.7mm.
4. An integrated, pusher electrode driver according to claim 3, wherein:
the diameter of the screw hole (4) is 1.4mm.
5. An integrated, pusher electrode driver according to claim 4, wherein:
the diameter of the iron column hole (2) is 0.6mm.
6. An integrated, pusher electrode driver according to claim 5, wherein:
the distance between the circle centers of the silicon tube hole (3) and the screw hole (4) is 1.7mm.
7. The integrated, pusher electrode driver of claim 6, wherein:
the distance from the center of the screw hole (4) to the supporting arm (5) and the adhesion arm (6) is 1.25mm.
8. An integrated, pusher electrode driver according to claim 7, wherein:
the supporting part, the screw driver (1) and the bottom bracket (7) are of an integrated structure.
9. An integrated, pusher electrode driver according to claim 8, wherein:
the supporting part, the screw driver (1) and the bottom bracket (7) are made of photosensitive resin.
10. An integrated, pusher electrode driver according to claim 9, wherein:
the supporting part, the screw driver (1) and the bottom bracket (7) are formed by 3D printing.
CN202111528246.2A 2021-12-14 2021-12-14 Integrated propelling electrode driver Active CN114469115B (en)

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Application Number Priority Date Filing Date Title
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Application Number Priority Date Filing Date Title
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CN114469115B true CN114469115B (en) 2023-07-18

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Citations (13)

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US7769421B1 (en) * 2005-07-13 2010-08-03 Neuralynx, Inc. Multi-electrode microdrive array
CN202619649U (en) * 2012-04-17 2012-12-26 中国科学院昆明动物研究所 Microelectrode thruster
CN203195686U (en) * 2013-04-16 2013-09-18 中国科学院昆明动物研究所 Bidirectional microelectrode propeller and microelectrode
CN104367314A (en) * 2014-11-05 2015-02-25 中国科学院深圳先进技术研究院 Electrode device for acute recording
CN104367319A (en) * 2014-11-05 2015-02-25 中国科学院深圳先进技术研究院 Electrode device for chronic recording
CN105251117A (en) * 2015-09-11 2016-01-20 郑州大学 Electrode applicable to animal brain area and adjustable in implantation depth
CN205665265U (en) * 2016-04-27 2016-10-26 哈尔滨理工大学 Movable electrode for partial discharge experiments
CN106618563A (en) * 2016-11-09 2017-05-10 中国人民解放军第三军医大学 Light reusable microelectrode propeller and embedding method thereof
CN107149472A (en) * 2017-06-26 2017-09-12 北京大学 Suitable for many brain area information gathering electrode propellers of rat
CN207679452U (en) * 2017-06-26 2018-08-03 北京大学 Electrode propeller and propeller body frame
CN110013346A (en) * 2019-05-13 2019-07-16 山西医科大学 A kind of integrated apparatus recorded for the administration of rat brain area and electroneurographic signal
CN110623771A (en) * 2019-10-12 2019-12-31 中国科学院深圳先进技术研究院 Stepping drug administration device

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US20210098341A1 (en) * 2019-09-30 2021-04-01 Paradromics Inc. Microelectrode array and methods of fabricating same

Patent Citations (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1317290A (en) * 2000-04-08 2001-10-17 中国科学院昆明动物研究所 Device for recording discharges of neures in rat brain
US7769421B1 (en) * 2005-07-13 2010-08-03 Neuralynx, Inc. Multi-electrode microdrive array
CN202619649U (en) * 2012-04-17 2012-12-26 中国科学院昆明动物研究所 Microelectrode thruster
CN203195686U (en) * 2013-04-16 2013-09-18 中国科学院昆明动物研究所 Bidirectional microelectrode propeller and microelectrode
CN104367314A (en) * 2014-11-05 2015-02-25 中国科学院深圳先进技术研究院 Electrode device for acute recording
CN104367319A (en) * 2014-11-05 2015-02-25 中国科学院深圳先进技术研究院 Electrode device for chronic recording
CN105251117A (en) * 2015-09-11 2016-01-20 郑州大学 Electrode applicable to animal brain area and adjustable in implantation depth
CN205665265U (en) * 2016-04-27 2016-10-26 哈尔滨理工大学 Movable electrode for partial discharge experiments
CN106618563A (en) * 2016-11-09 2017-05-10 中国人民解放军第三军医大学 Light reusable microelectrode propeller and embedding method thereof
CN107149472A (en) * 2017-06-26 2017-09-12 北京大学 Suitable for many brain area information gathering electrode propellers of rat
CN207679452U (en) * 2017-06-26 2018-08-03 北京大学 Electrode propeller and propeller body frame
CN110013346A (en) * 2019-05-13 2019-07-16 山西医科大学 A kind of integrated apparatus recorded for the administration of rat brain area and electroneurographic signal
CN110623771A (en) * 2019-10-12 2019-12-31 中国科学院深圳先进技术研究院 Stepping drug administration device

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