CN110623771B - Stepping drug administration device - Google Patents

Stepping drug administration device Download PDF

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Publication number
CN110623771B
CN110623771B CN201910969057.5A CN201910969057A CN110623771B CN 110623771 B CN110623771 B CN 110623771B CN 201910969057 A CN201910969057 A CN 201910969057A CN 110623771 B CN110623771 B CN 110623771B
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supporting plate
threaded rod
nut
drug delivery
delivery device
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CN110623771A (en
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吕丹
詹阳
孙语遥
欧阳雨林
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Shenzhen Institute of Advanced Technology of CAS
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Shenzhen Institute of Advanced Technology of CAS
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/48—Other medical applications
    • A61B5/4836—Diagnosis combined with treatment in closed-loop systems or methods
    • A61B5/4839—Diagnosis combined with treatment in closed-loop systems or methods combined with drug delivery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6846—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive
    • A61B5/6847—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive mounted on an invasive device
    • A61B5/685—Microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6846—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive
    • A61B5/6867—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive specially adapted to be attached or implanted in a specific body part
    • A61B5/6868—Brain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
    • A61D7/00—Devices or methods for introducing solid, liquid, or gaseous remedies or other materials into or onto the bodies of animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2503/00—Evaluating a particular growth phase or type of persons or animals
    • A61B2503/40—Animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2503/00—Evaluating a particular growth phase or type of persons or animals
    • A61B2503/42—Evaluating a particular growth phase or type of persons or animals for laboratory research
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
    • A61B2562/02—Details of sensors specially adapted for in-vivo measurements
    • A61B2562/0209—Special features of electrodes classified in A61B5/24, A61B5/25, A61B5/283, A61B5/291, A61B5/296, A61B5/053
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
    • A61B2562/12—Manufacturing methods specially adapted for producing sensors for in-vivo measurements
    • A61B2562/125—Manufacturing methods specially adapted for producing sensors for in-vivo measurements characterised by the manufacture of electrodes

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
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  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Abstract

The invention provides a steppable drug delivery device, comprising: the drug delivery device comprises a bearing assembly, a drug delivery catheter, a line pipe, a threaded rod, a nut, a signal recorder and a connecting rod; the middle part of the threaded rod is sleeved with a nut, the lower end of the threaded rod is contacted with the inner wall of the lower part of the bearing component, the upper end of the threaded rod penetrates through the upper part of the bearing component, and the upper end of the threaded rod is provided with a driving structure; a limiting part for limiting the rotation of the nut is further arranged in the bearing assembly, so that the nut can move up and down when the threaded rod rotates; when the nut moves up and down, the administration catheter is driven to move up and down. Through the device, can realize the step-by-step of pipe of dosing to can give bigger region and dose the operation, and in this scheme in the pipe of dosing add have be used for detecting the wire electrode of neuron signal, with this integration of having realized dosing and signal detection, and can have corresponding detection area of dosing, the acquisition of signal is more timely also more corresponding, thereby makes the signal of acquireing more accurate.

Description

Stepping drug administration device
Technical Field
The invention relates to the field of biomedical experimental devices, in particular to a stepping drug delivery device.
Background
In biological experiments, the administration methods of experimental animals are various, such as intraperitoneal injection, intravenous injection, intragastric administration and the like. However, for the study of the brain nerve and brain diseases, the above administration mode has serious disadvantages:
firstly, some medicines can not penetrate blood brain barrier and can not achieve the expected effect;
secondly, the dosage is small, and is generally several microliters or even less.
The conventional administration mode for experimental animals is limited in terms of the treatment of cranial nerves and brain diseases.
For this reason, there has been developed a central nervous system administration method, which is mostly used for the reaction of the target nucleus or brain region to the drug, and the currently internationally recognized intracerebral acute and chronic micro-administration method for experimental animals is the pre-embedded catheter method: in the specific method, a pipeline (conduit) with an inner core and a proper diameter and length is embedded in a target brain area or nucleus at the position of a stereotaxic apparatus, the exposed part of the pipeline is fixed on the surface of a skull by dental cement and small screws, in addition, after the drug administration, the signal of a neuron is detected and recorded, and the change of the electrical signal of the neuron is recorded through the brain drug administration so as to prove the drug effect or observe the behavioral change after the drug administration.
However, in this way, since the catheter is fixed, the administration can be performed only for a fixed position, and one such device cannot perform the administration for a plurality of positions, and cannot perform the administration for more comprehensive positions; and the current mode occupies too much volume, and a microelectrode array for signal recording cannot be embedded after a catheter is embedded in the brain, so that accurate recording of the electrical signal of the neuron after acute administration cannot be realized.
Thus, there is a need for a better drug delivery device.
Disclosure of Invention
Aiming at the defects in the prior art, the invention provides a stepping drug delivery device, through which the stepping of a drug delivery catheter can be realized, so that the drug delivery operation can be carried out on a larger area, in addition, in the scheme, the drug delivery catheter is additionally provided with an electrode wire for detecting neuron signals, so that the integration of drug delivery and signal detection is realized, the drug delivery area can be detected in a targeted manner, the acquisition of the signals is more timely and more targeted, and the acquired signals are more accurate.
Specifically, the present invention proposes the following specific examples:
the embodiment of the invention provides a stepping drug delivery device, which comprises: the device comprises a bearing component, a drug delivery catheter connected with the bearing component, a plurality of wire tubes, a threaded rod, a nut matched with the threaded rod, a signal recorder for recording neuron signals and a connecting rod for connecting an external stereotaxic apparatus;
the middle part of the threaded rod is sleeved with a nut, the lower end of the threaded rod is contacted with the inner wall of the lower part of the bearing component, the upper end of the threaded rod penetrates through the upper part of the bearing component, and the upper end of the threaded rod is provided with a driving structure; a limiting part for limiting the rotation of the nut is further arranged in the bearing assembly, so that when the threaded rod rotates, the nut can move up and down;
the outer wall of the administration catheter is fixedly connected with a plurality of wire pipes in a parallel mode; one or more wire tubes are internally provided with wire electrodes for detecting and transmitting neuron signals; the electrode wire is connected with the signal recorder; the nut is fixedly connected with the administration catheter, so that the administration catheter is driven to move up and down when the nut moves up and down.
In a specific embodiment, the carrier assembly includes: a first supporting plate positioned at the upper end, a second supporting plate positioned at the lower end and an upright post; wherein the content of the first and second substances,
the first supporting plate and the second supporting plate are respectively provided with a guide pipe connecting hole, a rod connecting hole and an upright post connecting hole;
the drug delivery catheter fixedly connected with the plurality of wire pipes respectively penetrates through the catheter connecting holes in the first supporting plate and the second supporting plate to realize connection with the bearing component; the connecting rods respectively penetrate through the rod connecting holes in the first supporting plate and the second supporting plate to be fixedly connected with the bearing assembly; the upright posts respectively penetrate through upright post connecting holes in the first supporting plate and the second supporting plate to be fixedly connected with the bearing assembly;
the first supporting plate is also provided with a driving hole for accommodating the threaded rod; a groove is formed in the second supporting plate;
the nut is arranged between the first supporting plate and the second supporting plate; the length of the threaded rod is longer than or equal to the height between the first support plate and the second support plate;
the lower end of the threaded rod penetrates through the driving hole and is sleeved with the threads until the lower end of the threaded rod contacts the bottom of the groove.
In a specific embodiment, the upright post is provided with a plurality of upright posts; the number of the upright post connecting holes is equal to or greater than that of the upright posts.
In a specific embodiment, the carrier assembly includes: a first supporting plate positioned at the upper end, a second supporting plate positioned at the lower end, a third supporting plate positioned in the middle and an upright post; wherein the content of the first and second substances,
the first support plate, the second support plate and the third support plate are all provided with a conduit connecting hole, a rod connecting hole and an upright post connecting hole;
the drug delivery catheter fixedly connected with the plurality of wire pipes respectively penetrates through the catheter connecting holes in the first support plate, the second support plate and the third support plate to be connected with the bearing component;
the connecting rod respectively penetrates through the rod connecting holes in the first supporting plate, the second supporting plate and the third supporting plate to be fixedly connected with the bearing assembly;
the upright post respectively penetrates through upright post connecting holes in the first supporting plate, the second supporting plate and the third supporting plate to realize the fixed connection with the bearing component;
the first supporting plate and the third supporting plate are provided with driving holes for accommodating the threaded rods;
the nut is arranged between the first supporting plate and the third supporting plate; the length of the threaded rod is longer than or equal to the height between the first support plate and the second support plate;
the threaded rod penetrates through the driving holes in the first supporting plate and the third supporting plate respectively, the lower end of the threaded rod is blocked by the second supporting plate, and the nut is sleeved on the threaded rod in the area between the first supporting plate and the third supporting plate.
In a specific embodiment, the lower end of the threaded rod is also provided with a head; wherein the head has a cross-sectional area greater than the cross-sectional area of the threaded portion of the threaded shank.
In a specific embodiment, the nut is in a polygonal shape, the pillar is square, and the limiting member includes one or more of the pillars.
In a specific embodiment, the driving structure comprises: a screw cross slot or a screw straight slot.
In a particular embodiment, the signal recorder is adhesively secured to the carrier assembly; the administration catheter fixedly connected with the plurality of line pipes is fixedly connected with the nut in a bonding mode.
In a specific embodiment, the conduit is a silicon conduit.
In a specific embodiment, the connection part of the electrode wire and the signal recorder is packaged in a mode of coating silver paint.
Therefore, the stepping drug delivery device can realize the stepping of the drug delivery catheter through the device, so that drug delivery operation can be performed in a larger area, in addition, the drug delivery catheter is additionally provided with the wire electrode for detecting neuron signals, the integration of drug delivery and signal detection is realized, the drug delivery area can be detected in a targeted manner, the acquisition of the signals is more timely and more targeted, and the acquired signals are more accurate.
Drawings
In order to more clearly illustrate the technical solutions of the embodiments of the present invention, the drawings needed to be used in the embodiments will be briefly described below, it should be understood that the following drawings only illustrate some embodiments of the present invention and therefore should not be considered as limiting the scope, and for those skilled in the art, other related drawings can be obtained according to the drawings without inventive efforts.
FIG. 1 is a schematic view of a step-able drug delivery device according to an embodiment of the present invention;
FIG. 2 is a schematic view of a step-able drug delivery device according to an embodiment of the present invention;
FIG. 3 is a schematic diagram of an exploded view of a step-able drug delivery device according to an embodiment of the present invention;
FIG. 4 is a schematic view of the structure of a drug delivery catheter, a wire conduit and a wire electrode of a step-by-step drug delivery device according to an embodiment of the present invention;
FIG. 5 is a schematic view of a threaded rod and nut of a step-able drug delivery device according to an embodiment of the present invention;
fig. 6 is a schematic structural diagram of a signal recorder in a step-able drug delivery device according to an embodiment of the present invention.
Illustration of the drawings:
1-a carrier assembly; 11-a first support plate; 12-a third support plate; 13-a second support plate; 14-upright post; 2-a drug delivery catheter; 3-a line pipe;
4-a threaded rod; 41-a drive structure;
5-a nut;
6-a signal recorder; 7-a connecting rod; 8-electrode wire.
Detailed Description
Various embodiments of the present disclosure will be described more fully hereinafter. The present disclosure is capable of various embodiments and of modifications and variations therein. However, it should be understood that: there is no intention to limit the various embodiments of the disclosure to the specific embodiments disclosed herein, but rather, the disclosure is to cover all modifications, equivalents, and/or alternatives falling within the spirit and scope of the various embodiments of the disclosure.
The terminology used in the various embodiments of the present disclosure is for the purpose of describing particular embodiments only and is not intended to be limiting of the various embodiments of the present disclosure. As used herein, the singular forms are intended to include the plural forms as well, unless the context clearly indicates otherwise. Unless otherwise defined, all terms (including technical and scientific terms) used herein have the same meaning as commonly understood by one of ordinary skill in the art to which the various embodiments of the present disclosure belong. The terms (such as those defined in commonly used dictionaries) should be interpreted as having a meaning that is consistent with their contextual meaning in the relevant art and will not be interpreted in an idealized or overly formal sense unless expressly so defined in various embodiments of the present disclosure.
Example 1
Embodiments of the present invention provide a stepped drug delivery device, as shown in fig. 1-6, comprising: the device comprises a bearing component 1, a drug delivery catheter 2 connected with the bearing component 1, a plurality of wire tubes 3, a threaded rod 4, a nut 5 matched with the threaded rod 4, a signal recorder 6 used for recording neuron signals and a connecting rod 7 used for connecting an external stereotaxic apparatus;
a nut 5 is sleeved in the middle of the threaded rod 4, the lower end of the threaded rod 4 contacts the inner wall of the lower part of the bearing component 1, the upper end of the threaded rod 4 penetrates through the upper part of the bearing component 1, and a driving structure 41 is arranged at the upper end of the threaded rod 4; a limiting part for limiting the rotation of the nut 5 is further arranged in the bearing component 1, so that when the threaded rod 4 rotates, the nut 5 can move up and down;
concretely, through drive structure 41 rotation threaded rod 4, threaded rod 4 is withstood because its lower extreme is withstood by the inner wall of the lower extreme of carrier assembly 1, can't continue downstream, therefore, the screw thread part rotates, and nut 5 also can not rotate by the spacing part restriction, and threaded rod 4 rotates, can drive nut 5 upwards or move down, and this nut 5 of pipe 2 fixed connection of dosing, thereby can drive pipe 2 of dosing and reciprocate reciprocating at nut 5's reciprocating, thereby realized the step-by of pipe 2 of dosing, pipe 2 can realize the processing of dosing of different positions or different degree of depth positions under drive structure 41's regulation with this.
The specific limiting member may have various embodiments, for example, a circular hole penetrating through the nut 5 from top to bottom is further drilled on the nut 5, in this case, the limiting member may be a cylindrical steel rod, and the limiting member limits the nut 5 in a manner of penetrating through the circular hole, in addition, the limiting member may also be a cylindrical structure matching the shape of the nut 5, and may also play a role in limiting the rotation of the nut 5, in addition, the nut 5 may also be limited in a manner of abutting against a certain side of the nut 5 through a certain side or a certain surface of the periphery of the square column by using a structure in which the periphery of the nut 5 is polygonal, for example, in a manner of a square column, so as to avoid the rotation thereof.
The outer wall of the administration catheter 2 is fixedly connected with a plurality of wire pipes 3 in a parallel mode; one or more of the conduits 3 houses therein a wire electrode 8 for detecting and transmitting neuronal signals; the electrode wire 8 is connected with the signal recorder 6; the nut 5 is fixedly connected with the administration catheter 2, so that the administration catheter 2 is driven to move up and down when the nut 5 moves up and down.
In order to detect the neuron signals of the administration position in the brain region at the first time, the conduit 3 is attached to the periphery of the administration catheter 2, the wire 8 is accommodated in the conduit 3, the detection of the signals is carried out while the administration is carried out, and the signals detected by the subsequent wire 8 are transmitted to the signal recorder 6 for processing and further analysis of the neuron signals can be transmitted to other devices.
Through this device, can realize dosing pipe 2 step-by-step to can give bigger region the operation of dosing, and in this scheme in dosing pipe 2 add have be used for detecting the wire electrode 8 of neuron signal, with this integration of dosing with signal detection has been realized, and can have pointed detection area of dosing, the acquisition of signal is more timely also more pointed, thereby makes the signal of acquireing more accurate.
In a specific embodiment, as shown in fig. 1-3, the load bearing assembly 1 comprises: a first support plate 11 positioned at the upper end, a second support plate 13 positioned at the lower end, a third support plate 12 positioned at the middle part, and a vertical column 14; the particular post 14 may act as a stop to limit the rotation of the nut 5, wherein,
the first support plate 11, the second support plate 13 and the third support plate 12 are all provided with a conduit connecting hole, a rod connecting hole and an upright post connecting hole;
the administration catheter 2 fixedly connected with a plurality of line tubes 3 respectively passes through the catheter connecting holes on the first support plate 11, the second support plate 13 and the third support plate 12 to realize connection with the bearing component 1;
the connecting rod 7 respectively penetrates through rod connecting holes in the first supporting plate 11, the second supporting plate 13 and the third supporting plate 12 to be fixedly connected with the bearing component 1;
the upright column 14 respectively passes through upright column 14 connecting holes on the first supporting plate 11, the second supporting plate 13 and the third supporting plate 12 to realize the fixed connection with the bearing component 1;
the first support plate 11 and the third support plate 12 are both provided with driving holes for accommodating the threaded rods 4;
the nut 5 is disposed between the first support plate 11 and the third support plate 12; the length of the threaded rod 4 is longer than or equal to the height between the first support plate 11 and the second support plate 13;
the threaded rod 4 respectively passes through the driving holes in the first supporting plate 11 and the third supporting plate 12, the lower end of the threaded rod 4 is blocked by the second supporting plate 13, and the nut 5 is sleeved on the threaded rod 4 in the area between the first supporting plate 11 and the third supporting plate 12.
Specifically, in this embodiment, the bearing assembly 1 includes 3 layers of supporting plates, specifically, a metal plate or a polymer material plate, the three layers of supporting plates are fixedly connected into a whole by the upright posts 14 penetrating through the three layers of supporting plates, the upright posts 14 serve as supports, and one or more of the upright posts 14 may be provided, specifically, as long as the three layers of supporting plates can be stably supported, so as to provide a fixed support for other assemblies.
The threaded rod 4 penetrates through the upper supporting plate and the middle supporting plate until the lower end of the threaded rod is propped against the lowest supporting plate, the threaded rod 4 is prevented from continuously descending, and the nut 5 is arranged between the two upper supporting plates; the nut 5 is fixedly connected with the administration catheter 2;
the administration catheter 2 fixedly connecting the plurality of line tubes 3 passes through these three support plates and moves based on the up-and-down movement of the nut 5.
As for the connecting rod 7, the connecting rod is fixed between the three layers of supporting plates, and may be cylindrical or cubic (for example, may be rectangular or the like), and the connecting rod 7 is used for connecting external equipment, and specifically, may be used for connecting a stereotaxic apparatus, so as to accurately position in the subsequent actual operation. The connecting rods 7 may also serve to support the three layers of support plates.
In a specific embodiment, for more stable rotation of the threaded rod 4, the lower end of the threaded rod 4 is further provided with a head (which may be shaped like the head of a screw or the head of a screw, etc.); wherein the cross-sectional area of the head is larger than that of the threaded portion in the threaded rod 4 for more stable rotation and less likely to break the lowermost support plate.
More specifically, the head may be in the shape of a semi-arc or a sphere.
Specifically, the nut 5 has a polygonal shape, such as a 6-sided polygon, a 4-sided polygon, a 5-sided polygon, and the pillar 14 has a square shape, and the limiting member includes one or more pillars 14. The upright column 14 can be abutted against one side of the nut 5, so that the rotation of the nut 5 is limited, and the up-and-down movement of the nut 5 is restrained.
In order to reduce other devices and avoid occupying more space, the driving structure 41 includes: a screw cross slot or a screw straight slot.
In this way, during a specific driving operation, a straight screwdriver or a cross screwdriver can be inserted into the driving structure 41 and manually rotated, so as to drive the entire threaded rod 4 to rotate.
In a particular embodiment, for a simpler and more reliable connection, the signal recorder 6 is adhesively fixed to the carrier assembly 1; the administration catheter 2 fixedly connecting the plurality of line tubes 3 is fixedly connected with the nut 5 in an adhesive manner.
In a particular embodiment, as shown in fig. 4, the conduit 3 may be a silicon conduit. The silicon tube can be made extremely thin, so that the occupied space is reduced as much as possible, the miniaturization of the whole device is facilitated, and the influence on the administration area is reduced as much as possible.
In a specific embodiment, for better signal transmission, the connection between the wire electrode 8 and the signal recorder 6 is encapsulated by painting silver paint. Better insulation can be realized through silver paint, and smooth transmission of signals is guaranteed.
In a specific embodiment, the length of the drug delivery catheter 2 can be set according to the brain region, and the length of the wire electrode 8 can be the same as or slightly longer than 1mm of the length of the drug delivery catheter 2. Then the drug delivery device (namely microelectrode array) is embedded in the brain and is pasted by dental cement, the wire electrode 8 is used for recording the electrical signal of the neuron, and the drug delivery catheter 2 is used for drug delivery, so that the change condition of the neuron can be rapidly recorded after drug delivery
The specific carrier assembly 1 may be composed of three PCB (printed circuit board) boards with a length of 7.5mm and a width of 6mm, and two copper posts with different lengths of 0.8mm and 0.6mm are fixed on the PCB board at the upper end, the PCB board in the middle is also fixed on the two copper posts, a screw (i.e. one specific embodiment of the threaded rod 4) is put into the PCB board from above and in the middle, and a nut 5 is screwed on the lower side of the screw. And then the third PCB is fixed on the long copper column and pressed on the bottom of the screw (at this time, the head of the screw on the upper PCB can be used as a driving structure 41) to prevent the bottom of the screw from moving downwards so that stepping cannot be performed.
And then a holder (namely a connecting rod 7) is inserted into the three layers of PCB boards, wherein the holder is used for fixing the whole microelectrode array on a stereo positioning instrument so as to conveniently bury the microelectrode array in a target brain area. And coating epoxy resin on the joints of the PCB and the copper columns and the holder, and blowing the epoxy resin glue by using a hot air gun until the epoxy resin glue is discolored and solidified. Care was taken not to apply epoxy to the screws, otherwise stepping was not possible.
Coating AB glue on the outer side wall of the administration catheter 2, and adhering 9 silicon tubes with the length of 1.2cm to the outer side of the administration catheter 2, wherein the silicon tubes surround the administration catheter 2 as much as possible. The administration tube 2 is inserted into the 3-layer PCB board, and the nut 5 and the administration tube 2 are adhered together by AB glue which is not adhered to the screw.
After the AB glue is dried, the connector (i.e., the signal recorder 6) is glued to the side of the three-layer PCB board. The prepared four-strand electrode wire 8 is inserted into a silicon tube, four single-strand electrode wires 8 are connected to the fly corners of the signal recorder 6, the four electrode wires 8 are connected to the four adjacent fly corners of the signal recorder 6 and then coated with silver paint, a ground wire reference line can be welded to a preset position of the administration catheter 2, and the fly corners of the connector are sealed by AB glue.
The specific signal recorder 6, as shown in fig. 6, may be a currently available device that functions to record the electrical signal of the neuron, and for example, a signal recorder 6 of model a79026-001, whose DATA CODE may be 1839, may be used. Of course, other existing signal recording devices may be used as long as the electrical signals of the neurons can be recorded.
Finally, the microelectrode array is inversely embedded into the mouse brain, and the change condition of the neuron signal can be recorded after the drug is administrated from the drug administration catheter 2.
Example 2
This embodiment 2 is the same as the foregoing embodiment 1 except for the bearing assembly 1, and specifically, in this embodiment, the bearing assembly 1 includes: a first support plate 11 positioned at the upper end, a second support plate 13 positioned at the lower end, and a column 14; wherein the content of the first and second substances,
the first support plate 11 and the second support plate 13 are respectively provided with a conduit connecting hole, a rod connecting hole and an upright post connecting hole;
the administration catheter 2 fixedly connected with a plurality of wire tubes 3 respectively passes through the catheter connecting holes in the first supporting plate 11 and the second supporting plate 13 to be connected with the bearing component 1; the connecting rods 7 respectively penetrate through rod connecting holes in the first supporting plate 11 and the second supporting plate 13 to be fixedly connected with the bearing component 1; the upright posts 14 respectively penetrate through upright post connecting holes in the first supporting plate 11 and the second supporting plate 13 to realize the fixed connection with the bearing component 1;
the first supporting plate 11 is also provided with a driving hole for accommodating the threaded rod 4; a groove is formed in the second supporting plate 13;
the nut 5 is arranged between the first support plate 11 and the second support plate 13; the length of the threaded rod 4 is longer than or equal to the height between the first support plate 11 and the second support plate 13;
the lower end of the threaded rod 4 penetrates through the driving hole and is sleeved with the threads until the lower end of the threaded rod 4 contacts the bottom of the groove.
Specifically, in this embodiment 2, only two support plates are provided, and in order to ensure the stability of the rotation of the threaded rod 4, the lower end of the threaded rod is not slid or moved, and a groove is provided to limit the lower end of the threaded rod 4.
Further, the column 14 is provided in plurality; the number of the pillar connecting holes may be equal to or greater than the number of the pillars 14.
Those skilled in the art will appreciate that the figures are merely schematic representations of one preferred implementation scenario and that the blocks or flow diagrams in the figures are not necessarily required to practice the present invention.
Those skilled in the art will appreciate that the modules in the devices in the implementation scenario may be distributed in the devices in the implementation scenario according to the description of the implementation scenario, or may be located in one or more devices different from the present implementation scenario with corresponding changes. The modules of the implementation scenario may be combined into one module, or may be further split into a plurality of sub-modules.
The above-mentioned invention numbers are merely for description and do not represent the merits of the implementation scenarios.
The above disclosure is only a few specific implementation scenarios of the present invention, however, the present invention is not limited thereto, and any variations that can be made by those skilled in the art are intended to fall within the scope of the present invention.

Claims (10)

1. A steppable drug delivery device comprising: the device comprises a bearing component, a drug delivery catheter connected with the bearing component, a plurality of wire tubes, a threaded rod, a nut matched with the threaded rod, a signal recorder for recording neuron signals and a connecting rod for connecting an external stereotaxic apparatus;
the middle part of the threaded rod is sleeved with a nut, the lower end of the threaded rod is contacted with the inner wall of the lower part of the bearing component, the upper end of the threaded rod penetrates through the upper part of the bearing component, and the upper end of the threaded rod is provided with a driving structure; a limiting part for limiting the rotation of the nut is further arranged in the bearing assembly, so that when the threaded rod rotates, the nut can move up and down;
the outer wall of the administration catheter is fixedly connected with a plurality of wire pipes in a parallel mode; one or more wire tubes are internally provided with wire electrodes for detecting and transmitting neuron signals; the electrode wire is connected with the signal recorder; the nut is fixedly connected with the administration catheter, so that the administration catheter is driven to move up and down when the nut moves up and down.
2. The step-able drug delivery device of claim 1, wherein the carrier assembly comprises: a first supporting plate positioned at the upper end, a second supporting plate positioned at the lower end and an upright post; wherein the content of the first and second substances,
the first supporting plate and the second supporting plate are respectively provided with a guide pipe connecting hole, a rod connecting hole and an upright post connecting hole;
the drug delivery catheter fixedly connected with the plurality of wire pipes respectively penetrates through the catheter connecting holes in the first supporting plate and the second supporting plate to realize connection with the bearing component; the connecting rods respectively penetrate through the rod connecting holes in the first supporting plate and the second supporting plate to be fixedly connected with the bearing assembly; the upright posts respectively penetrate through upright post connecting holes in the first supporting plate and the second supporting plate to be fixedly connected with the bearing assembly;
the first supporting plate is also provided with a driving hole for accommodating the threaded rod; a groove is formed in the second supporting plate;
the nut is arranged between the first supporting plate and the second supporting plate; the length of the threaded rod is longer than or equal to the height between the first support plate and the second support plate;
the lower end of the threaded rod penetrates through the driving hole, and the nut is sleeved until the lower end of the threaded rod contacts the bottom of the groove.
3. The step-able drug delivery device of claim 2, wherein the post is provided in plurality; the number of the upright post connecting holes is equal to or greater than that of the upright posts.
4. The step-able drug delivery device of claim 1, wherein the carrier assembly comprises: a first supporting plate positioned at the upper end, a second supporting plate positioned at the lower end, a third supporting plate positioned in the middle and an upright post; wherein the content of the first and second substances,
the first support plate, the second support plate and the third support plate are all provided with a conduit connecting hole, a rod connecting hole and an upright post connecting hole;
the drug delivery catheter fixedly connected with the plurality of wire pipes respectively penetrates through the catheter connecting holes in the first support plate, the second support plate and the third support plate to be connected with the bearing component;
the connecting rod respectively penetrates through the rod connecting holes in the first supporting plate, the second supporting plate and the third supporting plate to be fixedly connected with the bearing assembly;
the upright post respectively penetrates through upright post connecting holes in the first supporting plate, the second supporting plate and the third supporting plate to realize the fixed connection with the bearing component;
the first supporting plate and the third supporting plate are provided with driving holes for accommodating the threaded rods;
the nut is arranged between the first supporting plate and the third supporting plate; the length of the threaded rod is longer than or equal to the height between the first support plate and the second support plate;
the threaded rod penetrates through the driving holes in the first supporting plate and the third supporting plate respectively, the lower end of the threaded rod is blocked by the second supporting plate, and the nut is sleeved on the threaded rod in the area between the first supporting plate and the third supporting plate.
5. A stepped drug delivery device according to claim 4, wherein the threaded rod is further provided at its lower end with a head; wherein the head has a cross-sectional area greater than the cross-sectional area of the threaded portion of the threaded shank.
6. The stepwise drug delivery device of claim 4, wherein said nut is in the shape of a polygon, said posts are square, and said stop comprises one or more of said posts.
7. The step-able drug delivery device of claim 1, wherein the drive structure comprises: a screw cross slot or a screw straight slot.
8. A step-able drug delivery device as in claim 1, wherein said signal recorder is adhesively secured to said carrier assembly; the administration catheter fixedly connected with the plurality of line pipes is fixedly connected with the nut in a bonding mode.
9. The step-able drug delivery device of claim 1, wherein the conduit is a silicon tube.
10. A step-able drug delivery device as in claim 1, wherein the connection between the wire electrode and the signal recorder is encapsulated by silver paint.
CN201910969057.5A 2019-10-12 2019-10-12 Stepping drug administration device Active CN110623771B (en)

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