CN201399128Y - Micro-jet drug delivery device driven by piezoceramic stack - Google Patents
Micro-jet drug delivery device driven by piezoceramic stack Download PDFInfo
- Publication number
- CN201399128Y CN201399128Y CN2009201141410U CN200920114141U CN201399128Y CN 201399128 Y CN201399128 Y CN 201399128Y CN 2009201141410 U CN2009201141410 U CN 2009201141410U CN 200920114141 U CN200920114141 U CN 200920114141U CN 201399128 Y CN201399128 Y CN 201399128Y
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- Prior art keywords
- drug delivery
- piezoceramic stack
- micro
- ampoule
- piezoelectric
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- 238000012377 drug delivery Methods 0.000 title abstract 5
- 239000003708 ampul Substances 0.000 claims abstract description 20
- 238000006073 displacement reaction Methods 0.000 claims abstract description 13
- 230000008878 coupling Effects 0.000 claims abstract description 11
- 238000010168 coupling process Methods 0.000 claims abstract description 11
- 238000005859 coupling reaction Methods 0.000 claims abstract description 11
- 239000007921 spray Substances 0.000 claims description 19
- 239000000919 ceramic Substances 0.000 claims description 13
- 238000002347 injection Methods 0.000 abstract description 28
- 239000007924 injection Substances 0.000 abstract description 28
- 238000004519 manufacturing process Methods 0.000 abstract description 5
- 238000007920 subcutaneous administration Methods 0.000 abstract description 2
- 239000003814 drug Substances 0.000 description 10
- 229940079593 drug Drugs 0.000 description 6
- 230000000694 effects Effects 0.000 description 6
- 239000007788 liquid Substances 0.000 description 5
- 230000006837 decompression Effects 0.000 description 4
- 238000003860 storage Methods 0.000 description 4
- 238000005516 engineering process Methods 0.000 description 3
- 230000008602 contraction Effects 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 238000000520 microinjection Methods 0.000 description 2
- 208000032843 Hemorrhage Diseases 0.000 description 1
- 238000001467 acupuncture Methods 0.000 description 1
- 230000003321 amplification Effects 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- 238000009434 installation Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000003199 nucleic acid amplification method Methods 0.000 description 1
- 206010033675 panniculitis Diseases 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- 238000012797 qualification Methods 0.000 description 1
- 238000004904 shortening Methods 0.000 description 1
- 210000004304 subcutaneous tissue Anatomy 0.000 description 1
- 238000013268 sustained release Methods 0.000 description 1
- 239000012730 sustained-release form Substances 0.000 description 1
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- Infusion, Injection, And Reservoir Apparatuses (AREA)
Abstract
The utility model discloses a micro-jet drug delivery device driven by a piezoceramic stack, which belongs to the field of needless subcutaneous drug delivery devices in medical instruments. The micro-jet drug delivery device comprises an injecting device, the front end joint of the injecting device is sleeved with an ampoule, the injecting device comprises the piezoceramic stack which is mountedin a casing and provided with a flexible expansion piezoelectric amplifying mechanism, a coupling head is mounted at the front end of the piezoceramic stack, the outer wall of the coupling head is sleeved with a spring, and the coupling head is connected with a piston push rod of the ampoule. Besides, a lead screw driven by a stepping motor is mounted on a support of the casing, a stopper is coupled on the lead screw, and the upper end of the stopper penetrates through a displacement opening arranged at the bottom end of the casing to abut upon the back of the piezoceramic stack. The piezoceramic stack and the stepping motor are controlled by an identical control circuit. The micro-jet drug delivery device driven by a piezoceramic stack has convenient and fast retracting piston, low manufacturing cost, accurate injected dose, controllable injection speed and easy implementation.
Description
Technical field
The utility model discloses a kind of little spray doser that drives by the piezoelectric ceramics heap, belong to subcutaneous needleless doser technical field in the medical device.
Background technology
The pressure that common Needleless injection system adopts compressed air or spring to produce forms high-speed jet by miniature spray orifice, and medicine is expelled to into subcutaneous tissue.As a kind of method of transdermal administration, jet injection has many good qualities than traditional pin injection that has, such as safety, convenience, good, the minimizing acupuncture fear of drug diffusion absorbability, or the like.But through the development of decades, general jet injection technology still is not extensive use of.Exist multiple cause influence at present and applying of jet injection technology: the pain once in a while when causing injection and hemorrhage such as the uncertain meeting of spray penetration; Owing to be disposable injection, injected dose is not really accurate usually; Injection speed is uncontrollable, is not suitable for the drug conveying of sustained release.
In order to improve existing Needleless injection system, recently, U.S. scientist proposes a kind of pulse micro-spray device that drives of piling by piezoelectric ceramics.Can carry out Rapid Expansion after applying voltage to piezoelectric ceramics heap, promote piston and make medicine form high-speed jet from miniature spray orifice.Because the span of piezoelectric pile behind making alive is very little, medicine can form very tiny jet.This jet may be controlled to and just sees through skin layer, forms atraumatic and penetrates.In addition, this device can be controlled the dosage and the injection speed of each pulse injection by circuit, accomplishes accurate control, has overcome a series of problems of conventional spray injection technique.The applicant is preposition to apply for a patent " pulse injection apparatus " (application number 200810063468.X) and proposes a kind of pulse based on piezoelectricity administration jet injection system that declines, and this system forms by having piezoelectricity pulse injector, the ampoule that has spray orifice and the Drug Storage that displacement amplifies.Its injection operation principle is, voltage pulse signal is applied on the piezoelectric pile, at the peak value place of pulse signal, the piezoelectric pile elongation promotes piston and makes injection spray from spray orifice after amplifying, after pulse signal disappears, piezoelectric pile decompression and shortening, piston resets under the effect of spring force, re-injects injection in the ampoule cavity, carry out the injection second time, until all the injection injections in the Drug Storage are finished.The Drug Storage of this device becomes the original position near piston, the use that is used for saving one-way flow valves with the connector Position Design of ampoule.In practical operation, this design brings some problems, and ampoule often props up skin during owing to injection, because the ampoule front end does not have atmospheric pressure, can cause piston to be difficult to rollback.Micro one-way valve can address this problem, but the problem that exists the manufacturing cost height, is difficult to install.In clinical use, the normally disposable consumptive material of ampoule and Drug Storage, it is unpractical using manufacturing and the very high micro one-way valve of installation cost like this.
The utility model content
In order to address the above problem, this utility model provides a kind of piston rollback easily and fast, low cost of manufacture, the little spray doser by the driving of piezoelectric ceramics heap that injected dose is accurate, injection speed is controlled.
To achieve these goals, the technical scheme that this utility model adopted is:
A kind of little spray doser that drives by the piezoelectric ceramics heap, comprise the device of propelling that is set with ampoule on the front end interface, the described device of propelling comprises the piezoelectric pile that is installed in the housing and has flexible extension piezoelectricity enlarger, the piezoelectric pile front end is equipped with the coupling head that is with spring on the outer wall, and this coupling head is connected with the piston push rod of ampoule; One leading screw driven by stepper motors is installed on the support of housing, and coupling has link stopper on the leading screw, and this link stopper upper end is passed the displacement opening that is arranged on the housing bottom and kept out rear in piezoelectric pile; Piezoelectric pile and motor are controlled by same control circuit.
Described control circuit is installed in outside the housing.
Described link stopper is a wedge type block.
This utility model adopts motor to drive leading screw and rotates, the rotation of leading screw moves forward the link stopper of keeping out at the piezoelectric pile rear, the retraction displacement that is produced when being used for compensating the piezoelectric pile decompression, making Rapid Expansion after the pressurization of each piezoelectric pile can form displacement adds up, spray by the multiple pulses amount of declining like this and carry out the micro-injection injection, until all being injected, the medicinal liquid in the ampoule finishes, at this moment reverse by stepping driven by motor leading screw by control circuit again, the counter-rotating of leading screw drives link stopper and moves backward, up to piezoelectric pile under the effect of the elastic restoring force of spring, return to original position, piston also returns to original position under the pulling force effect of piston push rod simultaneously.
In a word, a kind of little spray doser that drives by piezoelectric ceramics heap of this utility model, piston rollback easily and fast, low cost of manufacture, injected dose is accurate, injection speed is controlled and easy realization.
The utility model is described in further detail below in conjunction with the drawings and specific embodiments.
Description of drawings
Fig. 1 is the structural representation of this utility model specific embodiment;
Fig. 2 has flexible piezoelectric pile schematic diagram of upholding the piezoelectricity enlarger in this utility model.
The specific embodiment
As shown in Figure 1, a kind of little spray doser that drives by the piezoelectric ceramics heap of this utility model, comprise the device of propelling that is set with ampoule 11 on the front end interface, propel device and comprise the piezoelectric pile 3 that is installed in the housing 1 and has flexible extension piezoelectricity enlarger, piezoelectric pile 3 front ends are equipped with the coupling head 9 that is with spring 2 on the outer wall, and this coupling head 9 is connected with the piston push rod 10 of ampoule 11.One leading screw 8 that is driven by motor 5 is installed on the support of housing 1, and coupling has link stopper 6 on the leading screw 8, and these link stopper 6 upper ends are passed the displacement opening 7 that is arranged on housing 1 bottom and kept out rear in piezoelectric pile 3.In order to make apparatus structure more compact, link stopper 6 is selected wedge type block for use.Piezoelectric pile 3 is controlled by same control circuit 4 with motor 5, and certainly, as preferred version, control circuit 4 preferably is installed in outside the housing 1.
Operation principle of the present utility model is as follows:
The ampoule 11 that medicinal liquid will be housed earlier is socketed on housing 1 front end interface.Before injection, piezoelectric pile 3 is in initial position, after opening the on and off switch of control circuit 4, control circuit 4 sends pulse voltage and is pressurized to piezoelectric pile 3, produce the stretch amount (displacement of general piezoelectric pile can reach the hundreds of micron after flexibility is upheld the amplification of piezoelectricity enlarger about tens microns) of a hundreds of micron.Because the rear end of piezoelectric pile 3 is propped up by link stopper 6, so the front end of piezoelectric pile 3 will be upheld the hundreds of micron forward suddenly, and the piston 13 that promotes in the ampoule 11 by piston push rod 10 moves ahead, medicinal liquid in the ampoule 11 will form high-speed jet and enter human body skin by miniature spray orifice 12 (injection diameter is at 50 to 100 microns usually) ejection at a high speed.Because the medicine liquid volume very little (usually less than 1 milliliter) that single pulse is sprayed, therefore this jet injection has the characteristics of atraumatic, accurate control equally.Piezoelectric pile 3 can be shunk when the pulse voltage decompression, in case and piezoelectric pile 3 is shunk, spring 2 also can produce retraction under the effect of elastic restoring force, finally drive piston 13 and get back to initial position.Therefore, for avoiding the generation of this situation, in the pulse voltage decompression, control circuit 4 sends signal to motor 5, drive leading screw 8 by motor 5 and rotate an angle, the rotation of leading screw 8 drives link stopper 6 and produces certain displacement forward, and this displacement compensates the contraction of piezoelectric pile 3 just.The design of control circuit 4 keeps synchronously the time that link stopper 6 moves ahead and the contraction of piezoelectric pile 3, and the front end of piezoelectric pile 3 just remains on and just injected the same position of finishing like this, and just the piston 13 in the ampoule 11 also remains on and just injected the same position of finishing.When next pulse voltage was added to piezoelectric pile 3, piston 13 moved ahead again and carries out micro-injection, and so circulation finishes until the medicinal liquid in the ampoule 11 is all injected.At this moment can allow stepping motor 5 reverse by control circuit 4, drive leading screw 8 counter-rotatings, the counter-rotating of leading screw 8 drives link stopper 6 and moves backward, up to piezoelectric pile 3 under the effect of the elastic restoring force of spring 2, return to original position, piston 13 also returns to original position under the pulling force effect of piston push rod 10 simultaneously.
As shown in Figure 2, have the flexible piezoelectric pile 3 of upholding the piezoelectricity enlarger by being clipped between two thin end caps at the polar piezoelectric ceramics 14 of thickness direction, the inner surface of each end cap all has a truncated cone-shaped hole.By piezoelectric ceramics 14 small radial displacements are amplified, convert axial displacement to, enlarged the stroke of piezoelectric actuator.This flexible piezoelectricity enlarger of upholding can be amplified to the displacement that piezoelectric pile 3 produces about 10 times, and produces tens newton's power output.
The foregoing description only is used to the inventive concept of the present utility model of explaining, but not to the qualification of this utility model rights protection, allly utilizes this design that this utility model is carried out the change of unsubstantiality, all should fall into protection domain of the present utility model.
Claims (3)
1, a kind of little spray doser that drives by the piezoelectric ceramics heap, comprise the device of propelling that is set with ampoule (11) on the front end interface, it is characterized in that: the described device of propelling comprises the piezoelectric pile (3) that is installed in the housing (1) and has flexible extension piezoelectricity enlarger, piezoelectric pile (3) front end is equipped with the coupling head (9) that is with spring (2) on the outer wall, and this coupling head (9) is connected with the piston push rod (10) of ampoule (11); One leading screw (8) that is driven by motor (5) is installed on the support of housing (1), is coupled with block (6) on the leading screw (8), and this block (6) upper end is passed the displacement opening (7) that is arranged on housing (1) bottom and kept out rear in piezoelectric pile (3); Piezoelectric pile (3) is controlled by same control circuit (4) with motor (5).
2, a kind of little spray doser that is driven by the piezoelectric ceramics heap as claimed in claim 1, it is characterized in that: described control circuit (4) is installed in outside the housing (1).
3, a kind of little spray doser that is driven by the piezoelectric ceramics heap as claimed in claim 1, it is characterized in that: described block (6) is a wedge type block.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2009201141410U CN201399128Y (en) | 2009-02-26 | 2009-02-26 | Micro-jet drug delivery device driven by piezoceramic stack |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2009201141410U CN201399128Y (en) | 2009-02-26 | 2009-02-26 | Micro-jet drug delivery device driven by piezoceramic stack |
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| Publication Number | Publication Date |
|---|---|
| CN201399128Y true CN201399128Y (en) | 2010-02-10 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN2009201141410U Expired - Lifetime CN201399128Y (en) | 2009-02-26 | 2009-02-26 | Micro-jet drug delivery device driven by piezoceramic stack |
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102629116A (en) * | 2012-04-12 | 2012-08-08 | 曾毅祺 | Control circuit and fluid output control device |
| CN105031768A (en) * | 2015-07-09 | 2015-11-11 | 刘英志 | Anesthetic needle capable of accurately controlling dosage |
| CN105709311A (en) * | 2016-01-18 | 2016-06-29 | 华南农业大学 | Needleless injector based on piezoelectric conversion and using method of needleless injector |
| CN105833418A (en) * | 2016-03-15 | 2016-08-10 | 南京航空航天大学 | Vascular administration therapy equipment based on piezoelectric driving and working method of vascular administration therapy equipment |
| CN107982612A (en) * | 2017-10-20 | 2018-05-04 | 南京航空航天大学 | Booster for medical syringe and its method of work based on double piezoelectric actuator ultra-precision drivings |
| CN110623771A (en) * | 2019-10-12 | 2019-12-31 | 中国科学院深圳先进技术研究院 | Stepping drug administration device |
| US10709843B2 (en) | 2015-05-10 | 2020-07-14 | Kolorpen Ltd. | Device and method for repetitive needleless injection |
-
2009
- 2009-02-26 CN CN2009201141410U patent/CN201399128Y/en not_active Expired - Lifetime
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102629116A (en) * | 2012-04-12 | 2012-08-08 | 曾毅祺 | Control circuit and fluid output control device |
| US10709843B2 (en) | 2015-05-10 | 2020-07-14 | Kolorpen Ltd. | Device and method for repetitive needleless injection |
| US11684718B2 (en) | 2015-05-10 | 2023-06-27 | Kolorpen Ltd. | Device and method for repetitive needleless injection |
| CN105031768A (en) * | 2015-07-09 | 2015-11-11 | 刘英志 | Anesthetic needle capable of accurately controlling dosage |
| CN105031768B (en) * | 2015-07-09 | 2019-05-21 | 刘英志 | A kind of anestetic needle that can accurately control dosage |
| CN105709311A (en) * | 2016-01-18 | 2016-06-29 | 华南农业大学 | Needleless injector based on piezoelectric conversion and using method of needleless injector |
| CN105833418A (en) * | 2016-03-15 | 2016-08-10 | 南京航空航天大学 | Vascular administration therapy equipment based on piezoelectric driving and working method of vascular administration therapy equipment |
| CN107982612A (en) * | 2017-10-20 | 2018-05-04 | 南京航空航天大学 | Booster for medical syringe and its method of work based on double piezoelectric actuator ultra-precision drivings |
| CN107982612B (en) * | 2017-10-20 | 2023-09-29 | 南京航空航天大学 | Injector booster driven by double piezoelectric actuators and working method thereof |
| CN110623771A (en) * | 2019-10-12 | 2019-12-31 | 中国科学院深圳先进技术研究院 | Stepping drug administration device |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| ASS | Succession or assignment of patent right |
Owner name: HENAN SHUGUANG MEDICAL EQUIPMENT CO., LTD. Free format text: FORMER OWNER: CHEN KAI Effective date: 20111027 |
|
| C41 | Transfer of patent application or patent right or utility model | ||
| COR | Change of bibliographic data |
Free format text: CORRECT: ADDRESS; FROM: 312000 SHAOXING, ZHEJIANG PROVINCE TO: 462000 LUOHE, HENAN PROVINCE |
|
| TR01 | Transfer of patent right |
Effective date of registration: 20111027 Address after: The coastal city of Luohe City, Henan Province, Yuanhui District Xiangjiang road 462000 Patentee after: Henan Shuguang Jianshi Medical Equipment Group Co., Ltd. Address before: 102 room 11, pearl garden, Yue Yue District, Zhejiang, Shaoxing, 312000 Patentee before: Chen Kai |
|
| C56 | Change in the name or address of the patentee | ||
| CP03 | Change of name, title or address |
Address after: Luohe City, Henan province 462000 Yuanhui District Riverside Metro Xiangjiang Road Patentee after: Henan Shugang Jianshi Medical Devices Group Co., Ltd. Address before: The coastal city of Luohe City, Henan Province, Yuanhui District Xiangjiang road 462000 Patentee before: Henan Shuguang Jianshi Medical Equipment Group Co., Ltd. |
|
| CX01 | Expiry of patent term |
Granted publication date: 20100210 |
|
| CX01 | Expiry of patent term |