CN105833418A - Vascular administration therapy equipment based on piezoelectric driving and working method of vascular administration therapy equipment - Google Patents
Vascular administration therapy equipment based on piezoelectric driving and working method of vascular administration therapy equipment Download PDFInfo
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- CN105833418A CN105833418A CN201610148105.0A CN201610148105A CN105833418A CN 105833418 A CN105833418 A CN 105833418A CN 201610148105 A CN201610148105 A CN 201610148105A CN 105833418 A CN105833418 A CN 105833418A
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- bolt
- titanium alloy
- alloy substrate
- piezoelectric ceramic
- ceramic piece
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
Abstract
The invention discloses vascular administration therapy equipment based on piezoelectric driving and a working method of the vascular administration therapy equipment; on the basis of the advantages of a dual-substrate structure, linear motion and rotating motion of the equipment are achieved, so that intravascular location and administration on pathological tissues are implemented. A medicine liquid is atomized by virtue of ultrasonic wave generated from piezoelectric ceramics, so that the release of the medicine liquid is achieved. Through an ultrasonic therapeutic action generated from the piezoelectric ceramics during vibrating, the pathological tissues are detected, and meanwhile, real-time administration to the pathological tissues is achieved and an absorbing rate is accelerated, so that absorbing efficiency is improved and the purpose of treating diseases with the least dosage is achieved. By virtue of the vascular administration therapy equipment, side effects caused by residual drugs in a conventional therapy method can be greatly relieved, the pathological tissues can be detected, and meanwhile, the pathological tissues can be cured rapidly, so that the purposes of being convenient for examination, free from wound, free from lead wire, free from pain, free from cross infection, low in dosage and high in cure rate are achieved.
Description
Technical field:
The present invention relates to a kind of vascular drug delivery therapy equipment based on Piezoelectric Driving and method of work thereof, it belongs to ultrasonic neck
Territory, MEMS field, ultrasound medicine, technical field of piezoelectricity.
Background technology:
Vascular drug delivery is a kind of administering mode that can immediately come into force, and is widely used clinically.But some medicine intravascular
Input, can cause extravasation tissue injury in various degree, and the lighter causes pain uncomfortable, and severe one causes dysfunction, very
To amputation and threat to life.The occur character with extravasation property medicine and the individual patients situation of exsomose injury have pass closely
System.Other is such as infusion amount, input speed, perfusion persistent period, pressure, drug level, tissue toxicity, tissue pressure etc.
This is also had an impact.Particularly intensive care patient, children's and old people, diabetes patient and vascular disease.One
Denier medicinal liquid exosmoses, and is more easy to cause damage.And ultrasonic importing medicine-feeding technology is the emerging therapeutic administration that closely grows up during the last ten years
Technology, by the physical action of low frequency ultrasound, makes horny layer inner cell wall or biological corridor expand, makes macromole medicine
Thing or medicinal liquid gradually can be input in the middle of pathological tissues from Ink vessel transfusing.This technology can make some originally can not absorb
Medicine be absorbed by tissue, originally can just be rapidly absorbed by absorbed medicine, therefore it can improve biological tissue's medicine
Permeability, expands the uniformity of drug distribution, thus improves the treatment rate of medicine.And the structure utilizing ultrasound electric machine is excellent
Gesture, can be accurately positioned pathological tissues at Ink vessel transfusing and be administered.
Summary of the invention:
The technical problem to be solved is for above-mentioned the deficiencies in the prior art, and provides a kind of based on Piezoelectric Driving
Vascular drug delivery therapy equipment and method of work.
The present invention adopts the following technical scheme that a kind of vascular drug delivery therapy equipment based on Piezoelectric Driving, closes including the first titanium
Auri body, the first piezoelectric ceramic piece being installed on the first titanium alloy substrate, the second titanium alloy substrate, it is installed on the second titanium
The second piezoelectric ceramic piece on alloy substrate, bolt, radiation under, rotating disk, the 3rd piezoelectric ceramic piece, the 4th piezoelectric ceramics
Sheet, lesion detection device, medicine storage device and nozzle containing photographic head, described first titanium alloy substrate is formed
There is the first hole running through the first left and right side of titanium alloy substrate, the second titanium alloy substrate is also formed through the second titanium and closes
Second hole of the left and right side of auri body, described bolt right-to-left is arranged in the second hole, the first hole successively, bolt
Left-end point is positioned in the first titanium alloy substrate, and the right end of bolt extends beyond outside the right edge of the second titanium alloy substrate,
The bolt partial outer face being positioned in the first hole is smooth, and the inner surface in the first hole is also smooth, bolt outer surface with
The inner surface in the first hole is matched in clearance, and the bolt partial outer face being positioned in the second hole is screw-shaped, the second hole interior
Surface is smooth, and the right end thread of described bolt is connected to the lateral edges of rotating disk, and described radiation under is installed on rotating disk
Cental axial position, described radiation under is positioned at the position below rotating disk and is provided with a cavity, and described 3rd piezoelectric ceramic piece is installed
On radiation under between rotating disk and cavity, described 4th piezoelectric ceramic piece is installed on the inside bottom surface of cavity, described
Nozzle and lesion detection device lay respectively at the left and right sides of radiation under lower surface, and described medicine storage device is positioned at the 4th pressure
Between electroceramics sheet and nozzle.
The present invention also adopts the following technical scheme that the method for work of a kind of vascular drug delivery therapy equipment based on Piezoelectric Driving,
Comprise the steps:
Step 1. vascular drug delivery based on Piezoelectric Driving therapy equipment enters person under inspection's Ink vessel transfusing, flows with blood, motion
Near pathological tissues, telling external operation personnel by the photographic head in lesion detection device, device is close to affected part；
Step 2. second piezoelectric ceramic piece, under the effect of sine and cosine voltage, makes the second titanium alloy substrate produce relative to it
The twist motion of axis, the second titanium alloy-based internal bolt part has screw thread, the twist motion of the second titanium alloy substrate,
Making bolt create linear motion, bolt is connected with rotating disk, makes whole rotating disk move along a straight line, so that nozzle pair
Quasi-lesion, then be discharged into after medicinal atomized in medicine storage device through nozzle by the vibration of the 4th piezoelectric ceramic piece
Pathological tissues surface；
Step 3. first piezoelectric ceramic piece, under the effect of sine and cosine voltage, makes the first titanium alloy substrate produce relative to it
The twist motion of axis, the first titanium alloy-based internal bolt part does not has screw thread, and bolt is by rubbing between surface both
Wiping power is driven, and bolt is rotated, and bolt is connected with rotating disk, makes whole rotating disk be rotated, from
And make radiation under rotate 180 °, then produce ultrasound wave by the vibration of the 3rd piezoelectric ceramic piece, pathological tissues is carried out reality
Time deep treatment, accelerate lesion region drug absorption, reach rapid healing purpose, repeating as above step, making spoke
Rhizoma Belamcandae rotates again 180 °；
Step 4. lesion detection device continues to detect the Cure of pathological tissues in real time, thus further controls
Pharmacy liquid measure, is finally reached and detects the purpose integrated with treatment, when completing to one after the process of lesion, for it
Its lesion, repeat the above steps.
There is advantages that the present invention utilizes Double substrate micro structural advantage, it is achieved the straight line of device is transported with rotating
Dynamic, pathological tissues positioned at Ink vessel transfusing and is administered.Utilize the ultrasonic fog medical solution that piezoelectric ceramics produces, thus
Realize the release of medicinal liquid.Piezoelectric ceramic vibration is utilized to produce the therapeutical effect of ultrasound wave, while detection pathological tissues,
Pathological tissues is administered and accelerates its absorption rate in real time, improves absorption efficiency, reach to cure with minimum medication amount
The purpose of disease.This vascular drug delivery therapy equipment can significantly reduce the secondary work that extra medicinal in traditional therapy produces
With, while detection pathological tissues, just pathological tissues is carried out rapid healing, reach to check that convenience, hurtless measure, nothing are led
Line, no pain, without cross infection, reduce dose and the purpose of high curative rate.
Accompanying drawing illustrates:
Fig. 1 is the structural representation of the present invention.
Fig. 2 is the operating diagram of titanium alloy substrate of the present invention.
Wherein:
1-the first titanium alloy substrate；2-the first piezoelectric ceramic piece；3-the second titanium alloy substrate；4-the second piezoelectric ceramic piece；
5-bolt；6-radiation under；7-rotating disk；8-the 3rd piezoelectric ceramic piece；9-the 4th piezoelectric ceramic piece；10-lesion detection device
(containing photographic head)；11-medicine storage device；12-nozzle.
Detailed description of the invention:
Refer to shown in Fig. 1 and Fig. 2, present invention vascular drug delivery based on Piezoelectric Driving therapy equipment includes the first titanium alloy
Matrix 1, first piezoelectric ceramic piece the 2, second titanium alloy substrate 3 being installed on the first titanium alloy substrate 1, it is installed on
The second piezoelectric ceramic piece 4 on two titanium alloy substrates 3, bolt 5, radiation under 6, rotating disk the 7, the 3rd piezoelectric ceramic piece 8,
4th piezoelectric ceramic piece 9, lesion detection device 10, medicine storage device 11 and nozzle 12 containing photographic head.The
First hole (sign) of the first left and right side of titanium alloy substrate 1 it is formed through on one titanium alloy substrate 1, second
Also second hole (sign) of the second left and right side of titanium alloy substrate 3 it is formed through, wherein on titanium alloy substrate 3
Bolt 5 right-to-left is arranged in the second hole, the first hole successively, and wherein to be positioned at first titanium alloy-based for the left-end point of bolt 5
In body 1, the right end of bolt 5 extends beyond outside the right edge of the second titanium alloy substrate 3.Wherein it is positioned in the first hole
Bolt partial outer face be smooth, the inner surface in the first hole is also smooth, bolt outer surface and the interior table in the first hole
Face is matched in clearance, and bolt 5 and the first titanium alloy substrate 1 are by the friction between bolt outer surface and the first internal surface of hole
Power is driven.The bolt partial outer face being positioned in the second hole is screw-shaped, and the inner surface in the second hole is smooth,
Bolt 5 and the second titanium alloy substrate 3 are to be connected with each other by the screw thread between bolt outer surface and the second internal surface of hole.Bolt
The right end thread of 5 is connected to the lateral edges of rotating disk 7, and radiation under 6 is installed on the cental axial position of rotating disk 7.Radiation under
Being positioned at the position below rotating disk 7 on 6 and be provided with a cavity 13, the 3rd piezoelectric ceramic piece 8 is installed on rotating disk 7 and cavity 13
Between radiation under 6 on, the 4th piezoelectric ceramic piece 9 is installed on the inside bottom surface of cavity 13, nozzle 12 and pathological changes
Detection device 10 lays respectively at the left and right sides of radiation under 6 lower surface, and medicine storage device 11 is positioned at the 4th piezoelectric ceramics
Between sheet 9 and nozzle 12.
The operation principle of present invention vascular drug delivery based on Piezoelectric Driving therapy equipment is as follows: the first piezoelectric ceramic piece 2,
Two piezoelectric ceramic pieces 4, respectively under the effect of sine and cosine voltage, make the first titanium alloy substrate 1 and the second titanium alloy substrate 3
Producing the twist motion relative to its axis, the bolt part being wherein arranged in the first titanium alloy substrate 1 does not has screw thread,
Bolt is rotated, and the bolt part being arranged in the second titanium alloy substrate 3 has screw thread, bolt to move along a straight line.
Bolt 5 is connected with rotating disk 7 again, so that whole rotating disk 7 completes straight line under the effect of sine and cosine voltage or rotates through
Journey.Lesion detection device 10 monitoring in real time and pathological tissues carried out cause of disease detection for device, it is also possible to detection is controlled
Liao Hou biological tissue Cure.By the vibration of the 4th piezoelectric ceramic piece 9 by the medicine mist in medicine storage device 11
It is discharged into pathological tissues surface through nozzle 12 after change, produces ultrasound wave by the vibration of the 3rd piezoelectric ceramic piece 8, to disease
Become tissue and carry out real-time deep treatment, accelerate the drug absorption of lesion region, reach rapid healing purpose.
The work process of present invention vascular drug delivery based on Piezoelectric Driving therapy equipment is as follows:
Step 1. vascular drug delivery based on Piezoelectric Driving therapy equipment enters person under inspection's Ink vessel transfusing, and it flows with blood, fortune
Moving near pathological tissues, tell external operation personnel by the photographic head in lesion detection device 10, device is the most close
Affected part.
Step 2. second piezoelectric ceramic piece 4, under the effect of sine and cosine voltage, makes the second titanium alloy substrate 3 produce relatively
Bolt part in the twist motion of its axis, the second titanium alloy substrate 3 has screw thread, so the second titanium alloy substrate 3
Twist motion, make bolt create linear motion.Bolt 5 is connected with rotating disk 7 again, makes whole rotating disk 7 carry out directly
Line moves.So that nozzle alignment lesion, then by the vibration of the 4th piezoelectric ceramic piece 9 by medicine storage device 11
In medicinal atomized after be discharged into pathological tissues surface through nozzle 12.
Step 3. first piezoelectric ceramic piece 2, under the effect of sine and cosine voltage, makes the first titanium alloy substrate 1 produce relatively
Bolt part in the twist motion of its axis, the first titanium alloy substrate 1 does not has screw thread, bolt by surface both it
Between frictional force be driven, bolt is rotated.Bolt 5 is connected with rotating disk 7 again, makes whole rotating disk 7 enter
Row rotary motion.So that radiation under rotates 180 °, then produce ultrasound wave by the vibration of the 3rd piezoelectric ceramic piece 8,
Pathological tissues is carried out real-time deep treatment, accelerates the drug absorption of lesion region, reach rapid healing purpose.At weight
Multiple as above step, makes radiation under rotate again 180 °.
Step 4. lesion detection device 10 continues to detect the Cure of pathological tissues in real time, thus further
Control amount of liquid medicine, be finally reached and detect the purpose integrated with treatment, when completing to one after the process of lesion, for
Other lesion, repeat the above steps.
The above is only the preferred embodiment of the present invention, it is noted that for those skilled in the art
For, some improvement can also be made under the premise without departing from the principles of the invention, these improvement also should be regarded as the present invention's
Protection domain.
Claims (2)
1. a vascular drug delivery therapy equipment based on Piezoelectric Driving, it is characterised in that: include the first titanium alloy substrate (1),
The first piezoelectric ceramic piece (2), the second titanium alloy substrate (3) that are installed on the first titanium alloy substrate (1), it is installed on
The second piezoelectric ceramic piece (4) on second titanium alloy substrate (3), bolt (5), radiation under (6), rotating disk (7),
3rd piezoelectric ceramic piece (8), the 4th piezoelectric ceramic piece (9), the lesion detection device (10) containing photographic head, medicine
Storage device (11) and nozzle (12), described first titanium alloy substrate (1) is formed through first titanium alloy-based
First hole of body (1) left and right side, the second titanium alloy substrate (3) is also formed through the second titanium alloy substrate (3)
Second hole of left and right side, described bolt (5) right-to-left is arranged in the second hole, the first hole successively, bolt (5)
Left-end point be positioned in the first titanium alloy substrate (1), the right end of bolt (5) extends beyond the second titanium alloy substrate (3)
Right edge outside, the bolt partial outer face being positioned in the first hole is smooth, and the inner surface in the first hole is also smooth,
The inner surface in bolt outer surface and the first hole is matched in clearance, and the bolt partial outer face being positioned in the second hole is screw-like
, the inner surface in the second hole is smooth, and the right end thread of described bolt (5) is connected to the lateral edges of rotating disk (7),
Described radiation under (6) is installed on the cental axial position of rotating disk (7), described radiation under (6) is positioned under rotating disk (7)
The position of side is provided with a cavity (13), and described 3rd piezoelectric ceramic piece (8) is installed on rotating disk (7) and cavity (13)
Between radiation under (6) on, described 4th piezoelectric ceramic piece (9) is installed on the inside bottom surface of cavity (13),
Described nozzle (12) and lesion detection device (10) lay respectively at the left and right sides of radiation under (6) lower surface, described
Medicine storage device (11) is positioned between the 4th piezoelectric ceramic piece (9) and nozzle (12).
2. a method of work for vascular drug delivery therapy equipment based on Piezoelectric Driving as claimed in claim 1, its feature
It is: comprise the steps
Step 1. vascular drug delivery based on Piezoelectric Driving therapy equipment enters person under inspection's Ink vessel transfusing, flows with blood, motion
Near pathological tissues, telling external operation personnel by the photographic head in lesion detection device (10), device is the most close
Affected part；
Step 2. second piezoelectric ceramic piece (4), under the effect of sine and cosine voltage, makes the second titanium alloy substrate (3) produce
The raw twist motion relative to its axis, the bolt part in the second titanium alloy substrate (3) has screw thread, the second titanium alloy
The twist motion of matrix (3), makes bolt create linear motion, and bolt (5) is connected with rotating disk (7), makes whole
Individual rotating disk (7) moves along a straight line, so that nozzle alignment lesion, then shaking by the 4th piezoelectric ceramic piece (9)
Dynamic it is discharged into pathological tissues surface by after medicinal atomized in medicine storage device (11) through nozzle (12)；
Step 3. first piezoelectric ceramic piece (2), under the effect of sine and cosine voltage, makes the first titanium alloy substrate (1) produce
The raw twist motion relative to its axis, the bolt part in the first titanium alloy substrate (1) does not has screw thread, bolt to pass through
Frictional force between surface both is driven, and bolt is rotated, and bolt (5) is connected with rotating disk (7),
Whole rotating disk (7) is made to be rotated, so that radiation under rotates 180 °, then by the 3rd piezoelectric ceramic piece (8)
Vibration produce ultrasound wave, pathological tissues is carried out real-time deep treatment, accelerates the drug absorption of lesion region, reach
Rapid healing purpose, is repeating as above step, makes radiation under rotate again 180 °；
Step 4. lesion detection device (10) continues to detect the Cure of pathological tissues in real time, thus enters again
One step controls amount of liquid medicine, is finally reached and detects the purpose integrated with treatment, when completing to one after the process of lesion,
For other lesion, repeat the above steps.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610148105.0A CN105833418B (en) | 2016-03-15 | 2016-03-15 | Blood vessel treatment device of dosing based on piezoelectricity drive |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610148105.0A CN105833418B (en) | 2016-03-15 | 2016-03-15 | Blood vessel treatment device of dosing based on piezoelectricity drive |
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| CN105833418A true CN105833418A (en) | 2016-08-10 |
| CN105833418B CN105833418B (en) | 2022-04-22 |
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| CN201610148105.0A Active CN105833418B (en) | 2016-03-15 | 2016-03-15 | Blood vessel treatment device of dosing based on piezoelectricity drive |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN107096124A (en) * | 2017-04-28 | 2017-08-29 | 南京航空航天大学 | A kind of ultrasonic decoction of the intestines and stomach based on Piezoelectric Driving promotees to ooze device and its method of work |
| CN109432586A (en) * | 2018-11-26 | 2019-03-08 | 南京航空航天大学 | A kind of targeted therapy ultrasound drug delivery system and working method applied to superficial tumor |
| CN115887815A (en) * | 2022-12-27 | 2023-04-04 | 北京大学 | Medicine injection pump and manufacturing method thereof |
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| CN201399128Y (en) * | 2009-02-26 | 2010-02-10 | 陈凯 | Micro-jet drug delivery device driven by piezoceramic stack |
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| CN102843063A (en) * | 2012-09-05 | 2012-12-26 | 哈尔滨工业大学 | Screw-thread-driven rotary-linear ultrasonic motor using columnar stator high-order bending vibration mode |
| CN205649728U (en) * | 2016-03-15 | 2016-10-19 | 南京航空航天大学 | Blood vessel drug treatment device based on piezoelectricity drive |
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| WO2008053396A2 (en) * | 2006-10-31 | 2008-05-08 | Koninklijke Philips Electronics N.V. | Design of swallowable multi-nozzle, dosing device for releasing medicines in the gastrointesinal tract |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN107096124A (en) * | 2017-04-28 | 2017-08-29 | 南京航空航天大学 | A kind of ultrasonic decoction of the intestines and stomach based on Piezoelectric Driving promotees to ooze device and its method of work |
| CN109432586A (en) * | 2018-11-26 | 2019-03-08 | 南京航空航天大学 | A kind of targeted therapy ultrasound drug delivery system and working method applied to superficial tumor |
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| CN115887815A (en) * | 2022-12-27 | 2023-04-04 | 北京大学 | Medicine injection pump and manufacturing method thereof |
| CN115887815B (en) * | 2022-12-27 | 2023-11-21 | 北京大学 | Medicine injection pump and manufacturing method thereof |
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