CN104367319A - Electrode device for chronic recording - Google Patents
Electrode device for chronic recording Download PDFInfo
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- CN104367319A CN104367319A CN201410616299.3A CN201410616299A CN104367319A CN 104367319 A CN104367319 A CN 104367319A CN 201410616299 A CN201410616299 A CN 201410616299A CN 104367319 A CN104367319 A CN 104367319A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
- A61B5/25—Bioelectric electrodes therefor
- A61B5/279—Bioelectric electrodes therefor specially adapted for particular uses
- A61B5/291—Bioelectric electrodes therefor specially adapted for particular uses for electroencephalography [EEG]
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Abstract
The invention provides an electrode device for chronic recording. The electrode device comprises an electrode skeleton and at least three electrodes, wherein hole channels which penetrate through the electrode skeleton in parallel are distributed in the electrode skeleton, and the electrodes penetrate through the hole channels to be fixed to the electrode skeleton, and are used for collecting chronic electrophysiological signals of multiple brain regions. Due to the fact that the chronic electrophysiological signals of the multiple brain regions can be provided at the same time, the research on neural circuits is facilitated, and the analysis of one neural circuit composed of one brain region and the related brain regions of the upstream part and the downstream part of the brain region is also facilitated.
Description
Technical field
The present invention relates to field of medical technology, particularly a kind of electrode assembly for carrying out chronic Recording.
Background technology
Electrophysiology technology is brain cognition and the technical method in disease of brain scientific research, the especially research of this brain network analysis aspect got most of the attention for 2 years.Electrophysiology technology mainly comprises Patch-clamp techniques and multichannel electrophysiological recording technology.Wherein patch clamp recording mainly has very important effect in the further investigation of full cell and even ion channel, and multichannel electrophysiological recording technology then mainly records a large amount of extracellular electrical activities.Along with computational science share fast development in recent years, especially large data store the arrival with the epoch analyzed, before making multichannel electrophysiological recording to the mass data problem of understanding difficulty be expected to solve, this electrophysiological technique is more and more indispensable.Compared to the single unit recording of patch clamp technique, record while multichannel electrophysiological recording can realize a large amount of cellular activity, can obtain more information; The more important thing is, the advantage of multichannel electrophysiological recording technology is the record under condition of living body.
Acute record and the large class of chronic Recording two can be divided in the multichannel electrophysiological recording technology of body.Wherein acute record mainly refers to the record under body record and light-duty rigid condition under anesthesia, and chronic Recording mainly refers to the electrophysiological recording on freely movable sobering animal.Therefore, the advantage of chronic Recording is also apparent---can connect with specific behavior, neuronic active situation in research related brain areas.As the neuron activity situation of corpus amygdaloideum in the fear of vola electricity irritation induction can be zoologizeed.
The Chronic Electrode sold in the market is also few, commercially available electrode is acute electrode mainly, if record effect is unsatisfactory after acute electrode is used for chronic implantation, this is mainly because organism causes the decline of electrode performance to cause to the inflammatory reaction that implant electrode produces.Wherein Utah electrode still can accept reluctantly for the neuron activity effect recording cortex, because brain gets over shallow-layer, as slighter in the inflammatory reaction of cortex to implant electrode.Therefore, the core group in deep, more lacks effective Chronic Electrode.
Some Chronic Electrodes are usually made by oneself for experiment in Ge great research institution.This mainly comprises the problem that two class methods solve above-mentioned chronic implantation inflammatory reaction: one, is improved the biocompatibility of electrode, reduces the inflammatory reaction of electrode surface, improve electrode performance by the method for electrode surface modifying interface; Its two, design a kind of can the electrode of stepping, by the electrode-inter nerve plane of a manufacture acute injury of coming in before electrode is in cerebral tissue before needing record, be then recorded to the neuron activity that electrode newly touches.Above-mentioned Chronic Electrode mainly refers to the electrode of Dan Nao district record, and also can realize the electrophysiological recording in Shuan Nao district at very little a part of laboratory.
In a neural circuitry research, usually relate to the parsing of a loop of a Ge Nao district and upstream and downstream related brain areas composition thereof, especially certain the specific neural circuitry involved by parsing behavior is needed, but the electrode in the electrode Huo Shuannao district in Dan Nao district of the prior art is unfavorable for the research to neural circuitry.
Summary of the invention
Embodiments providing a kind of electrode assembly for carrying out chronic Recording, being unfavorable for the technical problem of the research to neural circuitry with the electrode in the electrode Huo Shuannao district solving prior art Zhong Dannao district.This electrode assembly comprises: electrode skeleton and at least 3 electrodes, wherein, described electrode skeleton is distributed with and runs through described electrode skeleton and the duct be parallel to each other; Described at least 3 electrodes, are fixed on described electrode skeleton through described duct, and described at least 3 electrodes are for gathering the chronic electricity physiological signal in multiple brain district.
In one embodiment, described electrode skeleton is formed by least 3 pieces of thin plate levels are fixing, the described electrode assembly for carrying out chronic Recording also comprises: driver part, at least 3 pieces of thin plates described in fixing for level, and the distance described in adjustment at least 3 pieces of thin plates in the thin plate of the superiors and described at least 3 pieces of thin plates between other two pieces of thin plates, to make described in changing at least 3 electrodes enter the length in described multiple brain district.
In one embodiment, described driver part comprises: screw, and the thin plate of described screw the superiors from described at least 3 pieces of thin plates is through the default duct on described at least 3 pieces of thin plates; Fastener, is fixed on the screw rod of described screw, the thin plate of the superiors at least 3 pieces of thin plates described in described screw is fixed on by described fastener on the direction at vertical thin board plane, and allows described screw to rotate along the axle center of screw rod; Nut, is threaded with the screw rod lower end of described screw, in described at least 3 pieces of thin plates between other two pieces of thin plates, and is fixedly connected with these two pieces of thin plates.
In one embodiment, also comprise: driving arrangement, rotate described screw according to predetermined amount and angle.
In one embodiment, described at least 3 pieces of thin plates are printed circuit board (Printed Circuit Board, referred to as PCB).
In one embodiment, also comprise: optical fiber, be fixed on described electrode skeleton through described duct, for being described multiple brain districts input optical signal; And/or delivery tube, is fixed on described electrode skeleton through described duct, for being described multiple brain district input biochemical molecule.
In one embodiment, also comprise: guide member, be fixed in described duct, at least 3 electrodes described in guiding through described duct.
In one embodiment, also comprise: electrode clamping assembly, be connected with described electrode skeleton, the position in described multiple brain district can be entered at least 3 electrodes described in being clamped to by described electrode skeleton.
In embodiments of the present invention, by fixing at least 3 electrodes in duct that electrode skeleton distributes, and gathered the chronic electricity physiological signal in multiple brain district by least 3 electrodes simultaneously, achieve the chronic electricity physiological signal that simultaneously can gather multiple brain district, compared with the electrode in the electrode Huo Shuannao district in Dan Nao district of the prior art, the chronic electricity physiological signal in multiple brain district can be provided simultaneously, more be conducive to the research to neural circuitry, also help the parsing of a neural circuitry of a Ge Nao district and upstream and downstream related brain areas composition thereof.
Accompanying drawing explanation
Accompanying drawing described herein is used to provide a further understanding of the present invention, forms a application's part, does not form limitation of the invention.In the accompanying drawings:
Fig. 1 is the structure chart of a kind of electrode assembly for carrying out chronic Recording that the embodiment of the present invention provides;
Fig. 2 is the structure chart of a kind of concrete electrode skeleton that the embodiment of the present invention provides.
Detailed description of the invention
For making the object, technical solutions and advantages of the present invention clearly understand, below in conjunction with embodiment and accompanying drawing, the present invention is described in further details.At this, exemplary embodiment of the present invention and illustrating for explaining the present invention, but not as a limitation of the invention.
Inventor considers, the electrode in the electrode Huo Shuannao district in prior art Zhong Dannao district can not gather the chronic electricity physiological signal in multiple brain district simultaneously, make the research being unfavorable for carrying out neural circuitry, therefore a kind of adjustable, electrode assembly for carrying out acute record that simultaneously can gather the chronic electricity physiological signal in multiple brain districts is proposed, so that carry out the research of neural circuitry.
Based on this, in embodiments of the present invention, provide a kind of electrode assembly for carrying out chronic Recording, as shown in Figure 1, this electrode assembly comprises:
Electrode skeleton 101 and at least 3 electrodes 102, wherein,
Described electrode skeleton 101 is distributed with and runs through described electrode skeleton and the duct be parallel to each other;
Described at least 3 electrodes 102, are fixed on described electrode skeleton through described duct, and described at least 3 electrodes are for gathering the chronic electricity physiological signal in multiple brain district.
Known as shown in Figure 1, in embodiments of the present invention, by fixing at least 3 electrodes in duct that electrode skeleton distributes, and gathered the chronic electricity physiological signal in multiple brain district by least 3 electrodes simultaneously, achieve the chronic electricity physiological signal that simultaneously can gather multiple brain district, compared with the electrode in the electrode Huo Shuannao district in Dan Nao district of the prior art, the chronic electricity physiological signal in multiple brain district can be provided simultaneously, more be conducive to the research to neural circuitry, also help the parsing of a neural circuitry of a Ge Nao district and upstream and downstream related brain areas composition thereof.
During concrete enforcement, the above-mentioned electrode assembly for carrying out chronic Recording can also comprise the joint/pricking with needle of electrode and electrophysiological recording system, coupled, the pricking with needle of different pattern, different port number, different number can be selected as required, the half of pricking with needle is bonded on electrode skeleton securely, with electrodes adhere conducting, second half is connected with multichannel electrophysiological recording instrument.
During concrete enforcement, in order to enter the length of Brain TisX according to different demand adjustment electrode, in the present embodiment, as shown in Figure 2, described electrode skeleton 101 is formed by least 3 pieces of thin plates 201 level is fixing, the described electrode assembly for carrying out chronic Recording also comprises: driver part, at least 3 pieces of thin plates described in fixing for level, and the distance described in adjustment at least 3 pieces of thin plates in the thin plate of the superiors and described at least 3 pieces of thin plates between other two pieces of thin plates, to make described in changing at least 3 electrodes enter the length in described multiple brain district.Concrete, as shown in Figure 2, described driver part comprises: screw 202, and the thin plate of described screw the superiors from described at least 3 pieces of thin plates is through the default duct (namely screw 202 can pass the circular hole of same loci on described at least 3 pieces of thin plates) on described at least 3 pieces of thin plates; Fastener 203, on the screw rod being fixed on described screw (such as, by curing molding glue, fastener 203 can be fixed on the screw rod of screw 202), in at least 3 pieces of thin plates described in described screw is fixed on by described fastener on the direction at vertical thin board plane, (namely screw can not have a bit movement perpendicular on the direction of sheet plane for the thin plate of the superiors, also just suitable in the circular hole of thin plate, can not double swerve), and allow described screw to rotate along the axle center of screw rod; Nut 204, be threaded with the screw rod lower end of described screw, in described at least 3 pieces of thin plates between other two pieces of thin plates, and be fixedly connected with (such as with these two pieces of thin plates, nut 204 can be bonded in after between two pieces of thin plates, preferably coat appropriate curing molding glue (as 207 in Fig. 1,2, also be curing molding glue with the black shade on 702 antisymmetric angles, angle, place) be wrapped in nut side, during to guarantee screw turns, nut can not follow rotation between orifice plate, and curing molding glue can be AB glue etc.).After electrode skeleton 101 is fixing by above-mentioned driver part, can be advanced by rotary screw 202 or slow astern segment distance (such as, 30 microns), can move up and down with the thin plate of the superiors at least 3 pieces of thin plates described in making, adjust between the thin plate of the superiors at least 3 pieces of thin plates and other two pieces of thin plates in distance, to change the length that electrode enters Brain TisX, and then adjustment electrode enters the degree of depth of cerebral tissue.
During concrete enforcement, the thin plate forming above-mentioned electrode skeleton can be pcb board, and the shape of the present embodiment to the thin plate of the above-mentioned electrode skeleton of composition does not limit, and such as, can be rectangle as shown in Figure 2, also can be other regular shape.In order to the thin plate forming above-mentioned electrode skeleton can be firmly fixed, and the distance adjusted neatly between thin plate, the above-mentioned electrode assembly for carrying out chronic Recording can comprise multiple driver part, such as, if above-mentioned thin plate is rectangle, then can select 3 driver parts, be separately fixed on 3 angles of thin plate, after three groups of screws install completely, with same direction successively rotary screw by a small margin, nut moves up and down with piece orifice plate of two below, and the angle that the distance of movement is rotated by screw opposing nut determines.
During concrete enforcement, need the forward-reverse distance adjusted after implanting according to electrode, orlop gauge of sheet in adjustable electrode skeleton, the thicker then adjustable scope of thin plate is larger; Or can the thickness of adjusting nut, nut is thicker, then the scope that electrode is adjustable is also larger.
During concrete enforcement, in order to the rotation of screw accurately can be controlled, in the present embodiment, also comprise for the electrode assembly carrying out chronic Recording: driving arrangement, rotate described screw according to predetermined amount and angle.Such as, this driving arrangement can be have graduation mark or zero point tag line screwdriver, according to predetermined amount and angle rotary screw so that calculate electrode advance or retreat distance.
During concrete enforcement, in order to realize pharmacology or light hereditism and electrophysiological effective combination, even some neuronic function is rolled into a ball to some core in neural circuitry and carries out fine resolution, in the present embodiment, the above-mentioned electrode assembly for carrying out chronic Recording also comprises: optical fiber, be fixed on described electrode skeleton through described duct, for being described multiple brain districts input optical signal; And/or delivery tube, is fixed on described electrode skeleton through described duct, for being described multiple brain district input biochemical molecule.Concrete, optical fiber or delivery tube can stimulate with ambient light or the instrument and equipment such as administration pump be coupled, carry out disturbance parsing to the neural circuitry that certain specific behavior or emotion etc. in the animal of freely activity is correlated with.
During concrete enforcement, for the ease of electrode, optical fiber and delivery tube etc. are introduced in duct, in the present embodiment, as shown in Figure 1, the above-mentioned electrode assembly for carrying out acute record also comprises: directing assembly 103, is fixed in described duct, at least 3 electrodes described in guiding through described duct.Concrete, directing assembly 103 can be placed in the duct of the different loci of electrode skeleton, the demand experimentally designed, can be replaced with the input/output component of the electrophysiological recordings such as optoelectronic pole, optical fiber, delivery tube, administration electrode, labelling electrode, light genetics technology, neuro pharmacology correlation technique by electrod-array simple in way.
The present embodiment does not limit, as shown in Figure 2, the arrangement of certain way can be carried out in duct 205 on electrode skeleton 101 according to real needs, and then realize electrode, optical fiber, delivery tube etc. fixing, the relative position of fixed electrode, optical fiber, delivery tube etc., with the accurate location of realize target core group, each duct can one of them or combination in any in fixed electrode, optical fiber and delivery tube.
During concrete enforcement, for the ease of the fixing of electrode and ensure that electrode can accurate target approach brain district, in the present embodiment, as shown in Figure 2, the above-mentioned electrode assembly for carrying out acute record also comprises: electrode clamping assembly 206, be connected with described electrode skeleton, the position in described multiple brain district can be entered at least 3 electrodes described in being clamped to by described electrode skeleton, with holding electrode point vertically or enter cerebral tissue exactly with fixed angle.
The above-mentioned electrode assembly for carrying out chronic Recording, in actual use, electrode can be electrod-array also can be Single lead, can also be optoelectronic pole or electricity irritation-recording electrode and delivery tube etc.In addition, the present invention mainly lists the above-mentioned electrode assembly for carrying out chronic Recording for the relation research between brain district several in neural circuitry, but in actual use, according to different designs, lighting/inducing of the animal model of some disease can be realized by the administration of delivery tube, carry out the Results research of disease by photostimulation, medicine, neural circuitry between different behavior, different problem in science can be studied when being necessary and interact or shared mechanism etc.
In embodiments of the present invention, by fixing at least 3 electrodes in duct that electrode skeleton distributes, and the chronic electricity physiological signal in multiple brain district is gathered by least 3 electrodes, achieve the chronic electricity physiological signal that simultaneously can gather multiple brain district, compared with the electrode in the electrode Huo Shuannao district in Dan Nao district of the prior art, the chronic electricity physiological signal in multiple brain district can be provided simultaneously, more be conducive to the research to neural circuitry, also help the parsing of a neural circuitry of a Ge Nao district and upstream and downstream related brain areas composition thereof.
The foregoing is only the preferred embodiments of the present invention, be not limited to the present invention, for a person skilled in the art, the embodiment of the present invention can have various modifications and variations.Within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.
Claims (8)
1. for carrying out an electrode assembly for chronic Recording, it is characterized in that, comprising: electrode skeleton and at least 3 electrodes, wherein,
Described electrode skeleton is distributed with and runs through described electrode skeleton and the duct be parallel to each other;
Described at least 3 electrodes, are fixed on described electrode skeleton through described duct, and described at least 3 electrodes are for gathering the chronic electricity physiological signal in multiple brain district.
2. as claimed in claim 1 for carrying out the electrode assembly of chronic Recording, it is characterized in that, described electrode skeleton is formed by least 3 pieces of thin plate levels are fixing, and the described electrode assembly for carrying out chronic Recording also comprises:
Driver part, at least 3 pieces of thin plates described in fixing for level, and the distance described in adjustment at least 3 pieces of thin plates in the thin plate of the superiors and described at least 3 pieces of thin plates between other two pieces of thin plates, to make described in changing at least 3 electrodes enter the length in described multiple brain district.
3. as claimed in claim 2 for carrying out the electrode assembly of chronic Recording, it is characterized in that, described driver part comprises:
Screw, the thin plate of described screw the superiors from described at least 3 pieces of thin plates is through the default duct on described at least 3 pieces of thin plates;
Fastener, is fixed on the screw rod of described screw, the thin plate of the superiors at least 3 pieces of thin plates described in described screw is fixed on by described fastener on the direction at vertical thin board plane, and allows described screw to rotate along the axle center of screw rod;
Nut, is threaded with the screw rod lower end of described screw, in described at least 3 pieces of thin plates between other two pieces of thin plates, and is fixedly connected with these two pieces of thin plates.
4., as claimed in claim 3 for carrying out the electrode assembly of chronic Recording, it is characterized in that, also comprise:
Driving arrangement, rotates described screw according to predetermined amount and angle.
5. as claimed in claim 2 for carrying out the electrode assembly of chronic Recording, it is characterized in that, described at least 3 pieces of thin plates are printed circuit board.
6. according to any one of claim 1 to 5 for carrying out the electrode assembly of chronic Recording, it is characterized in that, also comprise:
Optical fiber, is fixed on described electrode skeleton through described duct, for being described multiple brain districts input optical signal; And/or
Delivery tube, is fixed on described electrode skeleton through described duct, for being described multiple brain district input biochemical molecule.
7. according to any one of claim 1 to 5 for carrying out the electrode assembly of chronic Recording, it is characterized in that, also comprise:
Guide member, is fixed in described duct, at least 3 electrodes described in guiding through described duct.
8. according to any one of claim 1 to 5 for carrying out the electrode assembly of chronic Recording, it is characterized in that, also comprise:
Electrode clamping assembly, is connected with described electrode skeleton, can enter the position in described multiple brain district at least 3 electrodes described in being clamped to by described electrode skeleton.
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| CN105251117A (en) * | 2015-09-11 | 2016-01-20 | 郑州大学 | Electrode applicable to animal brain area and adjustable in implantation depth |
| CN107149472A (en) * | 2017-06-26 | 2017-09-12 | 北京大学 | Suitable for many brain area information gathering electrode propellers of rat |
| CN108742942A (en) * | 2018-06-19 | 2018-11-06 | 中国科学院电子学研究所 | General anesthesia neuromechanism studies acute experiment platform and chronic experiment platform |
| CN110200595A (en) * | 2019-06-25 | 2019-09-06 | 中国科学院深圳先进技术研究院 | A kind of step-by-step movement detection device and system |
| CN111000548A (en) * | 2019-12-16 | 2020-04-14 | 中国科学院深圳先进技术研究院 | Reusable chronic multi-channel electrode device and application thereof |
| CN112915379A (en) * | 2020-02-24 | 2021-06-08 | 广州中医药大学(广州中医药研究院) | Electrical stimulation device |
| WO2021119953A1 (en) * | 2019-12-16 | 2021-06-24 | 中国科学院深圳先进技术研究院 | Reusable chronic multi-channel electrode device and application thereof |
| CN113274027A (en) * | 2021-06-17 | 2021-08-20 | 复旦大学 | In-vivo multichannel electroencephalogram signal recording device |
| CN114469115A (en) * | 2021-12-14 | 2022-05-13 | 中国科学院深圳先进技术研究院 | Integrated pushable electrode driver |
| WO2023109641A1 (en) * | 2021-12-17 | 2023-06-22 | 深圳先进技术研究院 | Integrated multi-channel stepping electrode stent and manufacturing method therefor |
| CN116784866A (en) * | 2023-06-13 | 2023-09-22 | 华南师范大学 | Implant device for brain research and method of use |
| CN117898745A (en) * | 2024-01-17 | 2024-04-19 | 浙江大学 | Angle-adjustable multi-channel clamping microelectrode propelling manipulator |
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| CN108742942A (en) * | 2018-06-19 | 2018-11-06 | 中国科学院电子学研究所 | General anesthesia neuromechanism studies acute experiment platform and chronic experiment platform |
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| CN112915379A (en) * | 2020-02-24 | 2021-06-08 | 广州中医药大学(广州中医药研究院) | Electrical stimulation device |
| CN113274027A (en) * | 2021-06-17 | 2021-08-20 | 复旦大学 | In-vivo multichannel electroencephalogram signal recording device |
| CN114469115A (en) * | 2021-12-14 | 2022-05-13 | 中国科学院深圳先进技术研究院 | Integrated pushable electrode driver |
| CN114469115B (en) * | 2021-12-14 | 2023-07-18 | 中国科学院深圳先进技术研究院 | Integrated propelling electrode driver |
| WO2023109641A1 (en) * | 2021-12-17 | 2023-06-22 | 深圳先进技术研究院 | Integrated multi-channel stepping electrode stent and manufacturing method therefor |
| CN116784866A (en) * | 2023-06-13 | 2023-09-22 | 华南师范大学 | Implant device for brain research and method of use |
| CN116784866B (en) * | 2023-06-13 | 2023-12-01 | 华南师范大学 | Implant device for brain research and method of use |
| CN117898745A (en) * | 2024-01-17 | 2024-04-19 | 浙江大学 | Angle-adjustable multi-channel clamping microelectrode propelling manipulator |
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