CN112656535A - Optical fiber connection photobiological treatment window for rats - Google Patents
Optical fiber connection photobiological treatment window for rats Download PDFInfo
- Publication number
- CN112656535A CN112656535A CN202110003403.1A CN202110003403A CN112656535A CN 112656535 A CN112656535 A CN 112656535A CN 202110003403 A CN202110003403 A CN 202110003403A CN 112656535 A CN112656535 A CN 112656535A
- Authority
- CN
- China
- Prior art keywords
- optical fiber
- end plate
- rat
- fiber channel
- treatment
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000013307 optical fiber Substances 0.000 title claims abstract description 61
- 241000700159 Rattus Species 0.000 title claims abstract description 30
- 230000000258 photobiological effect Effects 0.000 title abstract description 8
- 210000003205 muscle Anatomy 0.000 claims abstract description 6
- 239000000835 fiber Substances 0.000 claims description 9
- -1 polyethylene Polymers 0.000 claims description 7
- 239000000463 material Substances 0.000 claims description 5
- 239000004698 Polyethylene Substances 0.000 claims description 3
- 229920000573 polyethylene Polymers 0.000 claims description 3
- 238000001815 biotherapy Methods 0.000 claims 1
- 208000020431 spinal cord injury Diseases 0.000 abstract description 15
- 238000000034 method Methods 0.000 abstract description 8
- 230000008569 process Effects 0.000 abstract description 4
- 230000000007 visual effect Effects 0.000 abstract description 4
- 230000009286 beneficial effect Effects 0.000 abstract description 3
- 230000000694 effects Effects 0.000 description 8
- 230000003287 optical effect Effects 0.000 description 5
- 208000027418 Wounds and injury Diseases 0.000 description 4
- 230000006378 damage Effects 0.000 description 3
- 208000014674 injury Diseases 0.000 description 3
- 206010061218 Inflammation Diseases 0.000 description 2
- 239000004743 Polypropylene Substances 0.000 description 2
- 230000004054 inflammatory process Effects 0.000 description 2
- 210000005036 nerve Anatomy 0.000 description 2
- 229920001155 polypropylene Polymers 0.000 description 2
- 210000000278 spinal cord Anatomy 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- 238000010146 3D printing Methods 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 208000028389 Nerve injury Diseases 0.000 description 1
- 208000037273 Pathologic Processes Diseases 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 239000012620 biological material Substances 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 239000000084 colloidal system Substances 0.000 description 1
- 230000006837 decompression Effects 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 239000003018 immunosuppressive agent Substances 0.000 description 1
- 229940124589 immunosuppressive drug Drugs 0.000 description 1
- 230000028709 inflammatory response Effects 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 230000007659 motor function Effects 0.000 description 1
- 230000008764 nerve damage Effects 0.000 description 1
- 210000002569 neuron Anatomy 0.000 description 1
- 230000035764 nutrition Effects 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 230000009054 pathological process Effects 0.000 description 1
- 238000004393 prognosis Methods 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 230000008929 regeneration Effects 0.000 description 1
- 238000011069 regeneration method Methods 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000036573 scar formation Effects 0.000 description 1
- 208000037974 severe injury Diseases 0.000 description 1
- 230000009528 severe injury Effects 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 238000002054 transplantation Methods 0.000 description 1
Images
Landscapes
- Radiation-Therapy Devices (AREA)
Abstract
The invention discloses an optical fiber connection photobiologic treatment window for rats, which comprises an optical fiber channel, an upper end plate and a lower end plate. The optical fiber channel is used for the end part of the optical fiber to extend into, and the optical fiber channel is detachably connected with the joint of the optical fiber; the upper end plate and the lower end plate are fixedly connected to the two ends of the optical fiber channel respectively, the upper end plate is used for being fixedly connected with the skin through a suture line, the lower end plate is used for being fixedly connected with the paraspinal muscles through the suture line, and the upper end plate and the lower end plate are provided with threading holes for the suture line to pass through. Compared with the prior art, the invention can increase the effective dose of the photo-biological treatment reaching the spinal cord injury part, does not need frequent incision treatment on the spinal part of the rat, and is beneficial to the visual observation of the treatment process.
Description
Technical Field
The invention relates to the technical field of optical biological treatment devices, in particular to an optical fiber connection optical biological treatment window for rats.
Background
Spinal Cord Injury (SCI) is a worldwide problem, the pathological process of which is divided into two stages, primary injury and secondary injury, and secondary immune inflammatory response is a key link influencing SCI prognosis. There is no effective treatment method for SCI, which is mainly surgery decompression and nerve nutrition clinically, but has poor treatment effect on severe injury; the new treatment methods such as immunosuppressive drugs, cell transplantation, biological materials and the like have the defects of ethical problems, chemical toxic and side effects and the like, and cannot be popularized and applied in clinic.
Photobiomodulatology (PBM) has been widely used in clinical treatment of various diseases due to its clear inflammation-inhibiting effect, simple operation and no wound, and also has clear effect in repairing nerve injury. Earlier researches find that PBM can inhibit inflammatory reaction, reduce colloid scar formation, protect neuron activity, promote nerve regeneration and effectively promote the motor function recovery of SCI animals, and has good application prospect.
Currently, PBM therapy for SCI is primarily with percutaneous or intravascular radiation. Because the position of the spinal cord tissue is deep, the bone structure has a shielding effect on laser, and the skin muscle tissue has serious scattering and absorption on light energy, so that the light energy with effective treatment dosage can not completely reach the surface of the spinal cord, the curative effect is not exact, and the application of PBM in SCI treatment is seriously limited.
In the past, in a model for photobiological regulation treatment of rat spinal cord injury, percutaneous irradiation is mainly adopted or an incision is opened every time for irradiation, the effective dose of photobiological treatment reaching the spinal cord injury is seriously influenced by the mode of percutaneous irradiation, and serious injury is caused by the mode of opening the incision for irradiation.
Disclosure of Invention
The invention aims to provide an optical fiber connection photobiologic treatment window for rats, which can increase the effective dose of photobiologic treatment reaching spinal cord injury, does not need frequent incision treatment on spinal ridges of rats and is beneficial to the visual observation of the treatment process.
In order to achieve the purpose, the invention provides the following scheme:
the invention discloses an optical fiber connection photobiologic treatment window for rats, which comprises an optical fiber channel, an upper end plate and a lower end plate, wherein the optical fiber channel is used for the end part of an optical fiber to stretch into, and the optical fiber channel is detachably connected with a joint of the optical fiber; the upper end plate with lower end plate fixed connection respectively in fibre channel's both ends, the upper end plate is used for linking to each other through stylolite and skin are fixed, the lower end plate is used for linking to each other through stylolite and paraspinal muscle is fixed, the upper end plate with the lower end plate all is equipped with the confession the through wires hole that the stylolite passed.
Preferably, the optical fiber channel is in threaded connection with a connector of the optical fiber, and the optical fiber channel is provided with internal threads.
Preferably, the length of the internal thread is 3 mm.
Preferably, the number of the threading holes in the lower end plate and the upper end plate is four, and the four threading holes are distributed in a rectangular shape by taking the axis of the optical fiber channel as the center.
Preferably, the optical fiber channel has an outer diameter of 6mm, an inner diameter of 4mm, and a length of 8 mm.
Preferably, the threading holes on the lower end plate and the upper end plate are distributed in a square shape.
Preferably, the material of the optical fiber channel is polyethylene or polypropylene.
Preferably, the rat is 3D printed and molded by connecting the optical fiber with the photobiological treatment window.
Compared with the prior art, the invention has the following technical effects:
after the optical fiber connector is fixed by the optical fiber connection optical biological treatment window for the rat, light rays emitted by the optical fibers directly irradiate the spinal cord injury part, so that the effective dose of optical biological treatment reaching the spinal cord injury part can be increased, and the treatment effect is improved; after the optical fiber connection optical biological treatment window for the rat is fixed on the ridge of the rat, frequent incision treatment on the ridge of the rat is not needed, and visual observation of a treatment process is facilitated.
Drawings
In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings needed in the embodiments will be briefly described below, and it is obvious that the drawings in the following description are only some embodiments of the present invention, and it is obvious for those skilled in the art to obtain other drawings without creative efforts.
FIG. 1 is a front view of the rat in this example with a fiber-optic connection photobioreactor treatment window;
FIG. 2 is a side view of the rat in this example with the fiber attached photobiotherapy window;
FIG. 3 is an isometric view of the rat in this example with a fiber optic connection photobioreactor treatment window;
description of reference numerals: 100-rat connected photobiological therapeutic window with optical fiber; 1-a fiber channel; 2-upper end plate; 3-a lower end plate; 4-threading holes; 5-internal thread.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
The invention aims to provide an optical fiber connection photobiologic treatment window for rats, which can increase the effective dose of photobiologic treatment reaching spinal cord injury, does not need frequent incision treatment on spinal ridges of rats and is beneficial to the visual observation of the treatment process.
In order to make the aforementioned objects, features and advantages of the present invention comprehensible, embodiments accompanied with figures are described in further detail below.
As shown in fig. 1 to 3, this embodiment provides a rat optical fiber connection photobioreactor treatment window, which includes a fiber channel 1, an upper end plate 2 and a lower end plate 3.
The optical fiber channel 1 is used for the end part of the optical fiber to extend into, and the optical fiber channel 1 is detachably connected with the joint of the optical fiber. The upper end plate 2 and the lower end plate 3 are respectively fixedly connected to two ends of the optical fiber channel 1, the upper end plate 2 is fixedly connected with the skin through a suture line, and the lower end plate 3 is fixedly connected with the paraspinal muscles through the suture line. The upper end plate 2 and the lower end plate 3 are both provided with threading holes 4 for the suture threads to pass through.
When the optical fiber connection photobiological treatment window 100 for rats of the embodiment is used, after an incision is made at the ridge position of the rat, the upper end plate 2 and the skin are fixedly connected through the suture line, and the lower end plate 3 and the paraspinal muscles are fixedly connected through the suture line, so that the treatment window is fixed, and the treatment window cannot be displaced. Then, the joint of the external optical fiber is connected with the optical fiber channel 1, and the light emitted by the optical fiber directly irradiates the spinal cord injury part after passing through the optical fiber channel 1.
There are many detachable connection modes of the optical fiber connector and the optical fiber channel 1, and those skilled in the art can select the connection mode according to the needs. In this embodiment, the optical fiber channel 1 is connected to the joint of the optical fiber by a screw thread, and the optical fiber channel 1 is provided with an internal thread 5.
The particular size of the therapeutic window can be flexibly selected by one skilled in the art depending on the size of the test rat. In this embodiment, the outer diameter of the optical fiber channel 1 is 6mm, the inner diameter is 4mm, and the length is 8 mm; the outer diameter of the upper end plate 2 and the lower end plate 3 is 8mm, and the inner diameter is 4 mm; the length of the internal thread 5 is 3 mm.
In order to make this treatment window more firm, the through wires hole 4 on lower endplate 3 and the upper end plate 2 of this embodiment is four, and four through wires holes 4 use the axis of fibre channel 1 to be the rectangle distribution as the center. The threading holes 4 on the lower end plate 3 and the upper end plate 2 are preferably in square distribution.
In this embodiment, the material of the optical fiber channel 1 is a penta-toxic material such as polyethylene or polypropylene, and is integrally formed by 3D printing, and those skilled in the art can select other materials or forming methods according to the requirement.
The principle and the implementation mode of the present invention are explained by applying specific examples in the present specification, and the above descriptions of the examples are only used to help understanding the method and the core idea of the present invention; meanwhile, for a person skilled in the art, according to the idea of the present invention, the specific embodiments and the application range may be changed. In view of the above, the present disclosure should not be construed as limiting the invention.
Claims (8)
1. The optical fiber connection photobiologic treatment window for the rat is characterized by comprising an optical fiber channel, an upper end plate and a lower end plate, wherein the end part of an optical fiber is extended into the optical fiber channel, and the optical fiber channel is detachably connected with a joint of the optical fiber; the upper end plate with lower end plate fixed connection respectively in fibre channel's both ends, the upper end plate is used for linking to each other through stylolite and skin are fixed, the lower end plate is used for linking to each other through stylolite and paraspinal muscle is fixed, the upper end plate with the lower end plate all is equipped with the confession the through wires hole that the stylolite passed.
2. The rat optical fiber connection photobioreactor treatment window according to claim 1, wherein the optical fiber channel is threadedly connected to a connector of the optical fiber, and the optical fiber channel is provided with an internal thread.
3. The rat fiberoptic biotherapy window of claim 2, wherein the length of said internal thread is 3 mm.
4. The fiber-optic connection photobioreactor treatment window for rats according to claim 1, wherein the number of the threading holes in the lower end plate and the upper end plate is four, and the four threading holes are distributed in a rectangular shape with the axis of the fiber channel as the center.
5. The rat fiberoptic biotherapeutic window of claim 1, wherein said fiber channel has an outer diameter of 6mm, an inner diameter of 4mm and a length of 8 mm.
6. The rat optical fiber connection photobioreactor treatment window according to claim 1, wherein the threading holes on the lower end plate and the upper end plate are distributed in a square shape.
7. The rat optical fiber connection photobioreactor treatment window according to claim 1, wherein the material of the optical fiber channel is polyethylene or polypropylene ethylene.
8. The rat-used fiber-optic biotherapeutic window of claim 7, wherein said rat-used fiber-optic biotherapeutic window is 3D printed.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110003403.1A CN112656535A (en) | 2021-01-04 | 2021-01-04 | Optical fiber connection photobiological treatment window for rats |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110003403.1A CN112656535A (en) | 2021-01-04 | 2021-01-04 | Optical fiber connection photobiological treatment window for rats |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN112656535A true CN112656535A (en) | 2021-04-16 |
Family
ID=75412640
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202110003403.1A Pending CN112656535A (en) | 2021-01-04 | 2021-01-04 | Optical fiber connection photobiological treatment window for rats |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN112656535A (en) |
Citations (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103494607A (en) * | 2013-09-29 | 2014-01-08 | 张开元 | Brain buried pipe medicine applying cannula capable of recording cell external electric potential |
| CN105142529A (en) * | 2012-11-21 | 2015-12-09 | 电路治疗公司 | System and method for optogenetic therapy |
| CN106618729A (en) * | 2017-01-03 | 2017-05-10 | 中国科学院化学研究所 | Device for real-time dynamic observation of tumor microenvironment change in radio frequency treatment |
| CN106821532A (en) * | 2017-02-28 | 2017-06-13 | 上海市第六人民医院 | A kind of mouse ridge skin wing form frame |
| WO2018022775A1 (en) * | 2016-07-27 | 2018-02-01 | Zhang Jack K | Componentry and devices for light therapy delivery and methods related thereto |
| CN107684668A (en) * | 2017-05-23 | 2018-02-13 | 西安雅泽泰克医疗科技有限公司 | Laser therapeutic apparantus and spinal cord restorative procedure |
| CN208464322U (en) * | 2018-01-15 | 2019-02-05 | 中国人民解放军陆军军医大学第一附属医院 | A kind of model equipment of simulation Epidural cavity occupy-place compressing effect |
| CN110664507A (en) * | 2019-11-18 | 2020-01-10 | 中国科学院深圳先进技术研究院 | Disposable non-leakage intracranial drug delivery device |
| CN214857753U (en) * | 2021-01-04 | 2021-11-26 | 中国人民解放军空军军医大学 | Optical fiber connection photobiological treatment window for rats |
-
2021
- 2021-01-04 CN CN202110003403.1A patent/CN112656535A/en active Pending
Patent Citations (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105142529A (en) * | 2012-11-21 | 2015-12-09 | 电路治疗公司 | System and method for optogenetic therapy |
| CN103494607A (en) * | 2013-09-29 | 2014-01-08 | 张开元 | Brain buried pipe medicine applying cannula capable of recording cell external electric potential |
| WO2018022775A1 (en) * | 2016-07-27 | 2018-02-01 | Zhang Jack K | Componentry and devices for light therapy delivery and methods related thereto |
| CN106618729A (en) * | 2017-01-03 | 2017-05-10 | 中国科学院化学研究所 | Device for real-time dynamic observation of tumor microenvironment change in radio frequency treatment |
| CN106821532A (en) * | 2017-02-28 | 2017-06-13 | 上海市第六人民医院 | A kind of mouse ridge skin wing form frame |
| CN107684668A (en) * | 2017-05-23 | 2018-02-13 | 西安雅泽泰克医疗科技有限公司 | Laser therapeutic apparantus and spinal cord restorative procedure |
| CN208464322U (en) * | 2018-01-15 | 2019-02-05 | 中国人民解放军陆军军医大学第一附属医院 | A kind of model equipment of simulation Epidural cavity occupy-place compressing effect |
| CN110664507A (en) * | 2019-11-18 | 2020-01-10 | 中国科学院深圳先进技术研究院 | Disposable non-leakage intracranial drug delivery device |
| CN214857753U (en) * | 2021-01-04 | 2021-11-26 | 中国人民解放军空军军医大学 | Optical fiber connection photobiological treatment window for rats |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE60027300T2 (en) | PHOTOABLATIONSSYSTEM | |
| DE69738119T2 (en) | Balloon catheter for photodynamic therapy | |
| EP0292695B1 (en) | Device for circumferential irradiation of objects | |
| DE60031308T2 (en) | Treatment of sphincters with electrosurgical and active substances | |
| DE3804489A1 (en) | LIGHT BEAM RADIATOR FOR USE IN THE MEDICAL TREATMENT OF THE NOSE AND NECK PASSAGE | |
| Manni et al. | Trigeminal influences on extensor muscles of the neck | |
| EP0232511A1 (en) | An endoscope for guiding radiation light rays for use in medical treatment | |
| CH672739A5 (en) | ||
| WO2013168995A1 (en) | Wrinkle removing implant | |
| CN214857753U (en) | Optical fiber connection photobiological treatment window for rats | |
| DE3918609A1 (en) | LIGHT EMISSION DEVICE FOR USE IN MEDICAL TREATMENT | |
| Harris et al. | Parasympathetic influence on heart rate in euthermic and hibernating ground squirrels | |
| Schadé et al. | Electroencephalographic patterns of the goldfish (Carassius auratus L.) | |
| WO2012070851A2 (en) | Open-type module for treating the ear | |
| Kosenko et al. | Effect of xylazine–tiletamine–zolazepam on the local field potential of the rat olfactory bulb | |
| CN112656535A (en) | Optical fiber connection photobiological treatment window for rats | |
| Urban | Intraseptal administration of vasopressin and oxytocin affects hippocampal electroencephalogram in rats | |
| DE102020207582A1 (en) | Laser therapy fiber optic probe | |
| CN216748242U (en) | Ultraviolet LED skin inspection tester with adjustable amplification factor | |
| DE3736360A1 (en) | DEVICE FOR THE CLINICAL IMPLEMENTATION OF EXTERNAL LITHOTRIPSY | |
| CN108635044B (en) | Laser therapeutic instrument | |
| CN212547991U (en) | Absorbable optical fiber clamping device | |
| CN211327806U (en) | Hair care instrument | |
| CN112043969A (en) | Absorbable optical fiber clamping device | |
| WO2021067905A1 (en) | Multilayer and bouquet fiber-based neural probes and methods of making and uses thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination |