CN104874093A - Cerebrospinal fluid extracting device - Google Patents
Cerebrospinal fluid extracting device Download PDFInfo
- Publication number
- CN104874093A CN104874093A CN201510197536.1A CN201510197536A CN104874093A CN 104874093 A CN104874093 A CN 104874093A CN 201510197536 A CN201510197536 A CN 201510197536A CN 104874093 A CN104874093 A CN 104874093A
- Authority
- CN
- China
- Prior art keywords
- pipe
- cerebrospinal fluid
- tube
- silica gel
- jugular vein
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- External Artificial Organs (AREA)
Abstract
The invention discloses a cerebrospinal fluid extracting device which comprises a jugular vein indwelling tube device, a two-sided lateral ventricle indwelling tube device and cauda equine cone indwelling tube device. The two-sided lateral ventricle indwelling tube device comprises a two-sided lateral ventricle indwelling tube and a cerebrospinal fluid volumetric flask, the jugular vein indwelling tube device comprises a jugular vein indwelling tube and an intravenous syringe, and the cauda equine cone indwelling tube device comprises a cauda equine cone indwelling tube and a cerebrospinal fluid collector. The cerebrospinal fluid extracting device has the advantages that the cerebrospinal fluid extracting device is easy and convenient to operate, short in time and stable in operation, can become effective fast and can be used for research experiments on drugs which pass blood brain barriers, diversified nervous system diseases and nervous system disease targeted drug metabolism, intravenous administration can be facilitated, and a large quantity of cerebrospinal fluid can be continuously extracted by the aid of the cerebrospinal fluid extracting device.
Description
Technical field
The invention belongs to field of medical appliances, particularly a kind of cerebrospinal fluid extraction device.
Background technology
Cerebrospinal fluid is a kind of colourless transparent liquid produced by the choroid plexus cell of the ventricles of the brain, and its every indication has reacted biochemistry and the pathological condition of central nervous system.People are devoted to long-term cerebrospinal fluid of collecting continuously always and are also detected, to be used for studying central nervous system disease, such as alzheimer's disease and parkinson.And the research of cerebrospinal fluid is normal and intravenously administrable hook, to obtain practicality can act on nervous system and through the medicine of blood brain barrier.
Traditionally, cerebrospinal fluid is generally collected by cisternal puncture, about needs 20 minutes at every turn, can collect about 100 μ l, but the interval time between 2 times is 2 ~ 3 months.This method can not be used for collecting cerebrospinal fluid continuously for a long time.On this basis, " Chinese clinicist's magazine (electronic edition) " December the 7th volume the 24th phase classification number R-332 in 2013 discloses rodent cerebrospinal fluid sampling technique, start out a kind of method of putting pipe in cerebellomedullary cistern, can collect 30 – 50 μ L cerebrospinal fluid, the interval of 2 times is minimum is 3 hours at every turn.Experiment proves the sustainable collection of this method 2 ~ 3 weeks.But this model still can not realize continuously and collect cerebrospinal fluid in large quantities.
Summary of the invention
The object of this invention is to provide a kind of easy and simple to handle, the time is short, instant effect, and intravenously administrable is convenient, and running is stable, can extract the draw-out device of cerebrospinal fluid continuously in large quantities.
For achieving the above object, the invention provides following technical scheme:
Cerebrospinal fluid extraction device of the present invention, comprise jugular vein tube-placing device, bilateral tricorn puts and stay pipe device and horse hair circular cone tube-placing device, it is characterized in that, the bilateral tricorn indwelling tube that described bilateral tricorn indwelling tube device comprises cerebrospinal fluid volumetric flask and is connected with cerebrospinal fluid volumetric flask, described bilateral tricorn indwelling tube end connecting duct cap;
Described jugular vein tube-placing device comprises jugular vein and puts pipe and put the intravenous injector of managing and being connected with jugular vein, jugular vein is put pipe and is made up of a PE pipe and the first silica gel tube, a described PE pipe inserts in the first silica gel tube, fixed by glue between a described PE pipe and the first silica gel tube, be provided with a silica gel apart from a 2.5cm place, PE pipe front end and expand bubble;
Described horse hair circular cone tube-placing device comprises horse hair circular cone and puts pipe and be placed in the cerebrospinal fluid catcher that horse hair circular cone puts pipe end, described horse hair circular cone is put pipe and is made up of the 2nd PE pipe and the second silica gel tube, described 2nd PE pipe inserts in the second silica gel tube, fixed by glue between described 2nd PE pipe and the second silica gel tube, be respectively provided with a silica gel apart from the 2nd 2.5cm place, PE pipe front end and tail end 2cm place and expand bubble.
Further, described PE pipe range 3cm, silica gel pipe range 6cm.
The internal diameter of described PE pipe is 0.25mm, and external diameter is 0.5mm, and the internal diameter of described silica gel tube is 0.5mm, and external diameter is 1mm.
Further, described jugular vein puts pipe and horse hair circular cone tube-placing device rear end is provided with conduit and conduit cap, closes when not using, and improves device sealing.
Further, described jugular vein tube-placing device, bilateral tricorn indwelling tube and horse hair circular cone tube-placing device inside are hollow.Guarantee puts that pipe is unimpeded, and wherein jugular vein tube-placing device needs the perfusion regularly carrying out heparin sodium normal saline solution to keep clear, and improves administration and extracts cerebrospinal fluid efficiency.
During use, under operating microscope, insert jugular vein and put pipe, silica gel expands bubble can be prevented from jugular vein from putting pipe coming off, open tip catheter cap, connect and promote intravenous injector, in right atrium, injection is containing the medicine of chlorpromazine, micro-staight scissors are used to cut a V-shaped part on experiment thing spinal dura mater, spinal dura mater is picked up with micro-straight forceps, implant horse hair circular cone and put pipe, until the bubble that expands of PE tip end arrives otch, putting in pipe with horse hair circular cone has cerebrospinal fluid backflow to be as the criterion, determine that horse hair circular cone is put pipe and injected subarachnoid space, ligature is tightened up in pre-ligation, knotting is fixing, horse hair circular cone is put pipe and is finally passed from subcutaneous, the bubble that expands of tail end can prevent from horse hair circular cone from putting pipe coming off, use conduit cap to seal horse hair circular cone and put pipe end, for ensureing that putting pipe does not block, every day is respectively toward bilateral tricorn injecting heparin sodium normal saline solution and artificial cerebrospinal fluid at regular time and quantity.Postoperative 3rd day, cerebrospinal fluid volumetric flask is connected toward bilateral tricorn perfusion artificial cerebrospinal fluid by bilateral tricorn indwelling tube, the pressure of the ventricles of the brain increases and the cerebrospinal fluid of tail side is flowed out from subarachnoid space, opens horse hair circular cone and puts pipe tip catheter cap, and cerebrospinal fluid flows into cerebrospinal fluid catcher.
The jugular vein tube-placing device that the present invention adopts is used for injectable drug, bilateral tricorn indwelling tube device is for injecting artificial cerebrospinal fluid and normal saline, horse hair circular cone tube-placing device is for collecting cerebrospinal fluid, and each device cooperatively interacts running, has worked in coordination with cerebrospinal fluid extraction work.
Compared with prior art, the invention has the beneficial effects as follows: cerebrospinal fluid extraction setup time of the present invention is short, instant effect, intravenously administrable is convenient, easy and simple to handle, and running is stable, can extract cerebrospinal fluid in large quantities continuously.
Accompanying drawing explanation
In order to be illustrated more clearly in the embodiment of the present invention or technical scheme of the prior art, be briefly described to the accompanying drawing used required in embodiment or description of the prior art below, apparently, accompanying drawing in the following describes is only some embodiments of the present invention, for those of ordinary skill in the art, under the prerequisite not paying creative work, other accompanying drawing can also be obtained according to these accompanying drawings.
Below in conjunction with accompanying drawing, specific embodiments of the present invention are further described in detail;
Fig. 1 is package unit structural representation;
Fig. 2 is bilateral tricorn indwelling tube apparatus structure schematic diagram;
Fig. 3 is jugular vein tube-placing device structural representation;
Fig. 4 is horse hair circular cone tube-placing device structural representation;
Fig. 5 is that jugular vein puts tubular construction schematic diagram;
Fig. 6 is that horse hair circular cone puts tubular construction schematic diagram;
Each symbol of element explanation in figure
1, intravenous injector; 2, cerebrospinal fluid volumetric flask; 3, bilateral tricorn indwelling tube;
4, jugular vein puts pipe; 5, horse hair circular cone puts pipe; 6, cerebrospinal fluid catcher;
11, the first expands bubble; 12, glue; 13, one PE pipe; 14, ligature; 15, first silica gel tube;
21, the second expands bubble; 22, three expands bubble; 23, two PE pipe; 24, second silica gel tube.
Detailed description of the invention
Although the present invention is described with reference to concrete embodiment, those skilled in the art, by after reading foregoing description, can make apparent amendment and modification to the present invention, and without prejudice to the intent of the present invention and essence.The present invention has a mind to these amendments and modification to comprise within the scope of the claims.
With reference to accompanying drawing 1 ~ Fig. 6, cerebrospinal fluid extraction device of the present invention, comprises jugular vein tube-placing device, bilateral tricorn indwelling tube device and horse hair circular cone tube-placing device,
The bilateral tricorn indwelling tube that described bilateral tricorn indwelling tube device comprises cerebrospinal fluid volumetric flask and is connected with cerebrospinal fluid volumetric flask, described bilateral tricorn indwelling tube end connecting duct cap;
Described jugular vein tube-placing device comprises jugular vein and puts pipe 4 and put with jugular vein the intravenous injector 1 that pipe 4 is connected, jugular vein is put pipe 4 and is made up of a PE pipe 13 and the first silica gel tube 15, a described PE pipe 13 inserts in the first silica gel tube 15, fixed by glue 12 between a described PE pipe 13 and the first silica gel tube 15, be provided with a silica gel apart from a 2.5cm place, PE pipe 13 front end and expand bubble;
Described horse hair circular cone tube-placing device comprises horse hair circular cone and puts pipe 5 and be placed in the cerebrospinal fluid catcher 6 that horse hair circular cone puts pipe 5 end, described horse hair circular cone is put pipe 5 and is made up of the 2nd PE pipe 23 and the second silica gel tube 24, described 2nd PE pipe 23 inserts in the second silica gel tube 24, fixed by glue 12 between described 2nd PE pipe 23 and the second silica gel tube 24, be respectively provided with a silica gel apart from the 2nd 2.5cm place, PE pipe 23 front end and tail end 2cm place and expand bubble;
The long 3cm of described PE pipe 13, silica gel pipe range 6cm; The internal diameter of described PE pipe is 0.25mm, and external diameter is 0.5mm, and the internal diameter of described silica gel tube is 0.5mm, and external diameter is 1mm.Described jugular vein is put pipe 4 and horse hair circular cone and is put pipe 5 rear end and be provided with conduit and conduit cap, closes, improve device sealing when not using.Described jugular vein is put pipe 4, bilateral tricorn indwelling tube 3 and horse hair circular cone and is put pipe 5 inside and be hollow.
Operation principle: under operating microscope, insert jugular vein and put pipe 4, open tip catheter cap, connect and promote intravenous injector 1, in right atrium, injection is containing the medicine of chlorpromazine, micro-staight scissors are used to cut a V-shaped part on experiment thing spinal dura mater, spinal dura mater is picked up with micro-straight forceps, implant horse hair circular cone and put pipe 5, until second of the 2nd PE pipe 23 tip expands bubble 21 and arrives otch, putting in pipe 5 with horse hair circular cone has cerebrospinal fluid backflow to be as the criterion, determine that horse hair circular cone is put pipe 5 and injected subarachnoid space, ligature 14 is tightened up in pre-ligation, knotting is fixing, horse hair circular cone is put pipe 5 and is finally passed from subcutaneous, the 3rd of tail end expands bubble 22 can be prevented from horse hair circular cone from putting pipe 5 coming off, use conduit cap to seal horse hair circular cone and put pipe 5 end, for ensureing that putting pipe does not block, every day is respectively toward bilateral tricorn injecting heparin sodium normal saline solution and artificial cerebrospinal fluid at regular time and quantity.Postoperative 3rd day, cerebrospinal fluid volumetric flask 2 is connected toward bilateral tricorn perfusion artificial cerebrospinal fluid by bilateral tricorn indwelling tube 3, the pressure of the ventricles of the brain increases and the cerebrospinal fluid of tail side is flowed out from subarachnoid space, open horse hair circular cone and put pipe 5 tip catheter cap, cerebrospinal fluid flows into cerebrospinal fluid catcher 6, the cerebrospinal fluid can extracting 100 microlitres out per hour, and the extraction of sustainable more than 10 hours, can continue with this drug metabolism detected in cerebrospinal fluid to change, draw medicine cerebrospinal fluid metabolic chart.
Cerebrospinal fluid extraction setup time of the present invention is short, instant effect, and intravenously administrable is convenient, easy and simple to handle, running is stable, can extract cerebrospinal fluid in large quantities continuously, can be used for the research experiment of agent permeates therethrough blood brain barrier, multiple nervous system disease and the metabolism of nervous system disease targeted drug.
Claims (5)
1. a cerebrospinal fluid extraction device, comprise jugular vein tube-placing device, bilateral tricorn indwelling tube device and horse hair circular cone tube-placing device, it is characterized in that, the bilateral tricorn indwelling tube that described bilateral tricorn indwelling tube device comprises cerebrospinal fluid volumetric flask and is connected with cerebrospinal fluid volumetric flask, described bilateral tricorn indwelling tube end connecting duct cap;
Described jugular vein tube-placing device comprises jugular vein and puts pipe and put the intravenous injector of managing and being connected with jugular vein, jugular vein is put pipe and is made up of a PE pipe and the first silica gel tube, a described PE pipe inserts in the first silica gel tube, fixed by glue between a described PE pipe and the first silica gel tube, be provided with a silica gel apart from a 2.5cm place, PE pipe front end and expand bubble;
Described horse hair circular cone tube-placing device comprises horse hair circular cone and puts pipe and be placed in the cerebrospinal fluid catcher that horse hair circular cone puts pipe end, described horse hair circular cone is put pipe and is made up of the 2nd PE pipe and the second silica gel tube, described 2nd PE pipe inserts in the second silica gel tube, fixed by glue between described 2nd PE pipe and the second silica gel tube, be respectively provided with a silica gel apart from the 2nd 2.5cm place, PE pipe front end and tail end 2cm place and expand bubble.
2. cerebrospinal fluid extraction device as claimed in claim 1, is characterized in that, described PE pipe range 3cm, silica gel pipe range 6cm.
3. cerebrospinal fluid extraction device as claimed in claim 1, it is characterized in that, the internal diameter of described PE pipe is 0.25mm, and external diameter is 0.5mm, and the internal diameter of described silica gel tube is 0.5mm, and external diameter is 1mm.
4. cerebrospinal fluid extraction device as claimed in claim 1, is characterized in that, described jugular vein is put pipe and horse hair circular cone and put pipe rear end and be provided with conduit and conduit cap.
5. cerebrospinal fluid extraction device as claimed in claim 1, is characterized in that, described jugular vein is put pipe, bilateral tricorn indwelling tube and horse hair circular cone and put pipe inside and be hollow.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510197536.1A CN104874093A (en) | 2015-04-24 | 2015-04-24 | Cerebrospinal fluid extracting device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510197536.1A CN104874093A (en) | 2015-04-24 | 2015-04-24 | Cerebrospinal fluid extracting device |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN104874093A true CN104874093A (en) | 2015-09-02 |
Family
ID=53941931
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510197536.1A Pending CN104874093A (en) | 2015-04-24 | 2015-04-24 | Cerebrospinal fluid extracting device |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN104874093A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2018014167A1 (en) * | 2016-07-18 | 2018-01-25 | 刘金凤 | Device capable of temporarily storing cerebrospinal fluid |
| CN110646599A (en) * | 2019-09-25 | 2020-01-03 | 福州大学 | Device for rapidly extracting hydrogen sulfide in cerebrospinal fluid and serum sample and using method thereof |
| CN115541861A (en) * | 2022-12-05 | 2022-12-30 | 山东第一医科大学附属省立医院(山东省立医院) | Body fluid sampling and detecting device for neurology department |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN2391615Y (en) * | 1999-10-26 | 2000-08-16 | 鞠作泉 | Closed type cerebrospinal fluid replacement device |
| CN201044828Y (en) * | 2007-03-21 | 2008-04-09 | 张�浩 | An exterior transposing instrument for cerebrospinal liquid |
| CN101167657A (en) * | 2007-12-10 | 2008-04-30 | 北京师范大学 | Mouse cerebrospinal fluid microscale sampler and its special-purpose manufacturing equipment and using method |
| CN201453338U (en) * | 2009-02-17 | 2010-05-12 | 上海市第一人民医院 | Lumbar puncture needle |
| CN102784012A (en) * | 2012-03-16 | 2012-11-21 | 中山大学 | Blood brain barrier pharmacokinefic continuous dosing system and detecting system |
| CN202666168U (en) * | 2012-03-08 | 2013-01-16 | 新疆维吾尔自治区人民医院 | Double-airbag fixed drainage rubber hose |
| CN204619144U (en) * | 2015-04-24 | 2015-09-09 | 中山大学 | A kind of cerebrospinal fluid extraction device |
-
2015
- 2015-04-24 CN CN201510197536.1A patent/CN104874093A/en active Pending
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN2391615Y (en) * | 1999-10-26 | 2000-08-16 | 鞠作泉 | Closed type cerebrospinal fluid replacement device |
| CN201044828Y (en) * | 2007-03-21 | 2008-04-09 | 张�浩 | An exterior transposing instrument for cerebrospinal liquid |
| CN101167657A (en) * | 2007-12-10 | 2008-04-30 | 北京师范大学 | Mouse cerebrospinal fluid microscale sampler and its special-purpose manufacturing equipment and using method |
| CN201453338U (en) * | 2009-02-17 | 2010-05-12 | 上海市第一人民医院 | Lumbar puncture needle |
| CN202666168U (en) * | 2012-03-08 | 2013-01-16 | 新疆维吾尔自治区人民医院 | Double-airbag fixed drainage rubber hose |
| CN102784012A (en) * | 2012-03-16 | 2012-11-21 | 中山大学 | Blood brain barrier pharmacokinefic continuous dosing system and detecting system |
| CN204619144U (en) * | 2015-04-24 | 2015-09-09 | 中山大学 | A kind of cerebrospinal fluid extraction device |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2018014167A1 (en) * | 2016-07-18 | 2018-01-25 | 刘金凤 | Device capable of temporarily storing cerebrospinal fluid |
| CN110646599A (en) * | 2019-09-25 | 2020-01-03 | 福州大学 | Device for rapidly extracting hydrogen sulfide in cerebrospinal fluid and serum sample and using method thereof |
| CN115541861A (en) * | 2022-12-05 | 2022-12-30 | 山东第一医科大学附属省立医院(山东省立医院) | Body fluid sampling and detecting device for neurology department |
| CN115541861B (en) * | 2022-12-05 | 2023-03-10 | 山东第一医科大学附属省立医院(山东省立医院) | Body fluid sampling and detecting device for neurology department |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN104874093A (en) | Cerebrospinal fluid extracting device | |
| CN203227081U (en) | Implantable intravenous administration device | |
| CN204502064U (en) | A kind of craniocerebral operations postoperation subcutaneous hydrops drainage device | |
| CN204619144U (en) | A kind of cerebrospinal fluid extraction device | |
| CN203710531U (en) | External ventricular drainage device with function of arranging drainage pipe through subcutaneous tunnel | |
| CN203971078U (en) | A kind of dual pathways entry needle | |
| CN204219475U (en) | Disposable thoracocentesis abdominocentesis drain bag | |
| CN201930328U (en) | Subcutaneous indwelling needle | |
| CN207236807U (en) | Extract sticky cyst fluid Thyroid gland puncture drainage device | |
| CN203989254U (en) | Automatic liquid-stopping transfusion apparatus | |
| CN209253614U (en) | A kind of vein makes up a prescription infusion | |
| CN209437809U (en) | Multiple-head type self-destroyed syringe | |
| CN203694231U (en) | Needle-free connecting piece type infusion apparatus | |
| CN203001550U (en) | Burette type infusion apparatus with indwelling needle | |
| CN201939795U (en) | Disposable indwelling needle jacket | |
| CN201710813U (en) | Infusion device with capabilities of automatic medicine delivery and radiation shielding | |
| CN203169704U (en) | Siphon infusion set | |
| CN206151996U (en) | Marrow filters and infusion device | |
| CN216725420U (en) | Syringe for anesthesia department | |
| CN201286907Y (en) | Jugular vein imbedding type injector | |
| CN204500724U (en) | A kind of can the remaining needle of Real-time Collection blood or administration | |
| CN204147346U (en) | One can supporting transfusion utensil connecting pipe | |
| CN205460192U (en) | Implanted venous transfusion connects syringe needle with infusion in port | |
| CN201996926U (en) | Injector | |
| CN208339538U (en) | A kind of fat transfer needle |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| EXSB | Decision made by sipo to initiate substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20150902 |
|
| RJ01 | Rejection of invention patent application after publication |