CN103494190A - Preparation method for polyghace-seche ginseng softgel - Google Patents
Preparation method for polyghace-seche ginseng softgel Download PDFInfo
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- CN103494190A CN103494190A CN201310406321.7A CN201310406321A CN103494190A CN 103494190 A CN103494190 A CN 103494190A CN 201310406321 A CN201310406321 A CN 201310406321A CN 103494190 A CN103494190 A CN 103494190A
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- LPMXVESGRSUGHW-HBYQJFLCSA-N ouabain Chemical compound O[C@@H]1[C@H](O)[C@@H](O)[C@H](C)O[C@H]1O[C@@H]1C[C@@]2(O)CC[C@H]3[C@@]4(O)CC[C@H](C=5COC(=O)C=5)[C@@]4(C)C[C@@H](O)[C@@H]3[C@@]2(CO)[C@H](O)C1 LPMXVESGRSUGHW-HBYQJFLCSA-N 0.000 description 1
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- -1 trypsase Proteins 0.000 description 1
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Classifications
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L5/00—Preparation or treatment of foods or foodstuffs, in general; Food or foodstuffs obtained thereby; Materials therefor
- A23L5/51—Concentration
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
- A23P10/00—Shaping or working of foodstuffs characterised by the products
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Health & Medical Sciences (AREA)
- Nutrition Science (AREA)
- Mycology (AREA)
- Cosmetics (AREA)
- Medicines Containing Plant Substances (AREA)
- Enzymes And Modification Thereof (AREA)
Abstract
A preparation method for polyghace-seche ginseng softgel belongs to the field of health food containing polyghaceseche and other plants, and helps to solve the problem that the extraction ratio of polyghaceseche polysaccharide is low by employing water extraction, and helps to fill up the blank that polyghaceseche and ginseng are taken as raw materials for immune food in the present field of plant health food. The preparation method comprises the following: weighing polyghaceseche and fresh ginseng according to a weight ratio, adding distilled water, crushing, processing by a colloid mill, heating, adding a mixture of cellulase and hemicellulase for enzymatic hydrolysis, adding protease for enzymatic hydrolysis, heating, bathing with water, filtering to remove slags and obtain polyghace-seche ginseng extract, and preparing into softgel. In the polyghace-seche ginseng softgel finished product prepared by using the preparation method, the polyghaceseche polysaccharide extraction ratio is improved by 50% or more than that of water extraction.
Description
Technical field
The present invention relates to the plant health food processing technique field such as radix polygonati officinalis, be specifically related to a kind of preparation method of radix polygonati officinalis ginseng soft capsule.
Background technology
Radix polygonati officinalis has another name called the Tibetan custard, the female withers, and is the dry rhizome of liliaceous plant radix polygonati officinalis.The radix polygonati officinalis cold nature, distinguish the flavor of sweet flat, attaches to the lung and stomach meridians, and has nourishing yin to moisten dryness, the merit promoted the production of body fluid to quench thirst.Contain the Multiple components such as polysaccharide, steroid saponin, flavones, alkaloid, cardiac glycoside in radix polygonati officinalis, the highest fragrant solomonseal rhizome polyoses of content wherein, as one of effective medicinal ingredient of radix polygonati officinalis, fragrant solomonseal rhizome polyoses have immunological regulation, hypoglycemic, anti-ageing, adjust the pharmacologically actives such as blood fat and anti peroxidation of lipid, enhancing mouse hypoxia-bearing capability, antitumor action.
The main component of ginseng is panaxoside (Ginsenoside), and China scientific worker has now isolated 39 kinds of Saponins from ginseng.Except panaxoside, ginseng also contains panaxan, Radix Ginseng protein, ginseng essential oil, amino acid, inorganic elements, peptide matters, multivitamin, the materials such as organic acid, alkaloid, fats, flavonoids, enzyme, sterol, nucleosides, lignin.
Panaxoside is the main active of extracting from Araliaceae ginseng, stem, leaf, has the quantity of leucocyte of increasing, improves body immunity, promotes metabolism, antifatigue, the anti-ageing effect of waiting for a long time; The panaxan can the enhanced machine body immunity function, can overcome the side effect that chemotherapy of tumors and radiotherapy cause.
At present, usually adopt water extraction to extract the polysaccharide in radix polygonati officinalis, the problem that this water extraction exists is that the recovery rate of fragrant solomonseal rhizome polyoses is only 25% left and right, does not reach industrial needs at all, has caused the serious waste of material.Yet the immune food that radix polygonati officinalis and ginseng be primary raw material of take have not been reported.
Summary of the invention
For solve existing adopt water extraction to extract the problem that recovery rate that fragrant solomonseal rhizome polyoses exists is low and fill up existing plant field of health care food take the blank of the immune food that the radix polygonati officinalis ginseng is primary raw material, the invention provides a kind of preparation method of radix polygonati officinalis ginseng soft capsule.
The present invention is that the technical scheme that adopts of technical solution problem is as follows:
The preparation method of radix polygonati officinalis ginseng soft capsule, condition and the step of the method are as follows:
(1) weight ratio according to beautiful bamboo ︰ fresh ginseng=1 ︰ 1～9 ︰ 1 takes radix polygonati officinalis and fresh ginseng, with radix polygonati officinalis and fresh ginseng gross weight 8～12 times, adds distilled water, is crushed to 13～17 orders, obtains the mixture A of radix polygonati officinalis and fresh ginseng;
(2) weight ratio according to mixture A ︰ distilled water=1 ︰ 0.1～1 ︰ 5 adds distilled water, crosses colloid mill, obtains latex B;
(3) latex B is warming up to 40～60 ℃, according to the weight ratio of the mixture of latex B ︰ cellulase and hemicellulase=1 ︰ 100～1 ︰ 10000, adds the mixture of cellulase and hemicellulase, enzymolysis 50～70min, obtain enzymolysis product C;
In the mixture of described cellulase and hemicellulase, the weight ratio of cellulase and hemicellulase is 1 ︰ 1;
(4) weight ratio according to enzymolysis product C ︰ protease=1 ︰ 100～1 ︰ 10000 adds protease, and enzymolysis 50～70min, obtain enzymolysis product D;
(5) enzymolysis product D is warming up to 60～100 ℃, water-bath 50～70min, obtain mixture E;
(6), by the mixture E filter cleaner, being evaporated to density is 1 ︰ 1.1～1 ︰ 1.2, obtains the radix polygonati officinalis Radix Ginseng extractum;
(7) the radix polygonati officinalis Radix Ginseng extractum is made to radix polygonati officinalis ginseng soft capsule.
Preferably, in step (1), according to the weight ratio of Yu Zhu ︰ fresh ginseng=2 ︰ 1～5 ︰ 1, take radix polygonati officinalis and fresh ginseng.
Preferably, in step (1), according to the weight ratio of Yu Zhu ︰ fresh ginseng=7 ︰ 3, take radix polygonati officinalis and fresh ginseng.
Preferably, in step (1), radix polygonati officinalis and fresh ginseng are crushed to 15 orders.
Preferably, in step (2), according to the weight ratio of mixture A ︰ distilled water=1 ︰ 1, add distilled water.
Preferably, in step (3), latex B is warming up to 50 ℃.
Preferably, in step (3), according to the mixture of latex B ︰ cellulase and hemicellulase=weight ratio of 1 ︰ 1000, add the mixture of cellulase and hemicellulase.
Preferably, in step (4), described protease is trypsase, Proteinase K, papain, chymotrypsin or Collagenase.
Preferably, in step (4), according to the weight ratio of enzymolysis product C ︰ protease=1 ︰ 1000, add protease.
Preferably, in step (5), enzymolysis product D is warming up to 80 ℃.
The invention has the beneficial effects as follows:
1, radix polygonati officinalis, sweet, return lung stomach warp, ginseng, sweet, micro-hardship, tepor, return lung spleen the heart channel of Hang-Shaoyin, the present invention reuses radix polygonati officinalis, gets the radix polygonati officinalis nourishing yin to moisten dryness, the merit promoted the production of body fluid to quench thirst, be aided with ginseng energy reinvigoration, YIN and YANG balance regulating, help machine to make yin and yang in equilibrium, strengthen the merit of resisting outer heresy, two things share, both tonifying Qi and blood, went back to again this training unit, helps body to resist the merit of outer heresy;
2, radix polygonati officinalis processing of Panax ginseng technique of the present invention is in conjunction with modern phyical methods and biological technique method, adopt the colloid mill ultramicro grinding, take full advantage of the characteristics that enzyme is made the catalyst high specificity and can not exerted an influence to the unclassified stores composition, adopt cellulase, hemicellulase and protease carry out the specificity degraded, not only increase the content of soluble cellulose and hemicellulose (being dietary fiber) in extract, help lend some impetus to gastrointestinal peristalsis, and increased polyoses content and the protein content in the product, add protease, increased the abundance of polypeptide, contribute to improve the nutritive value of product, promote nutraceutical digestion and absorption, contribute to improve immunity, promoted the release of cellular content simultaneously, improved effective utilization of radix polygonati officinalis and ginseng,
3, in the radix polygonati officinalis ginseng soft capsule finished product that utilizes preparation method of the present invention to obtain, the recovery rate of fragrant solomonseal rhizome polyoses has improved more than 50% than the polysaccharide extract rate under water extraction, as one of effective medicinal ingredient of radix polygonati officinalis, fragrant solomonseal rhizome polyoses have immunological regulation, hypoglycemic, anti-ageing, adjust the pharmacologically actives such as blood fat and anti peroxidation of lipid, enhancing mouse hypoxia-bearing capability, antitumor action, thereby, that radix polygonati officinalis ginseng soft capsule of the present invention can be used for making is hypoglycemic, adjust blood fat and anti peroxidation of lipid, in the medicine of antitumor action, have certain medical value.
4, it is supplementary that the present invention adds the ginseng mediation, panaxoside in ginseng has the body immunity of raising, promotes metabolism, antifatigue, the anti-ageing effect of waiting for a long time, make final products radix polygonati officinalis ginseng soft capsule of the present invention there is stronger immune function of human body, antifatigue and the anti-ageing effect of waiting for a long time, can extensively promote and make to produce.
The specific embodiment
Experiment material:
Radix polygonati officinalis is purchased from Jilin Province Ze Kang pharmaceutcal corporation, Ltd;
Fresh ginseng, purchased from the Jilin Fusong, in present embodiment, is not cooked restriction for the kind of fresh ginseng, and ginseng, red ginseng etc. all can in vain;
Cellulase, hemicellulase, trypsase, Proteinase K, papain, chymotrypsin or Collagenase are purchased from middle section space in morning bio tech ltd;
Distilled water is purchased from market.
In present embodiment, the method that just the radix polygonati officinalis Radix Ginseng extractum makes soft capsule, for having method now, can adopt a kind of realization in following two kinds of methods: 1, pressing: the first step, prepare capsule material glue.According to the capsule material formula, gelatin is put into to the distilled water immersion and make its expansion, after gelatin dissolves, unclassified stores is added in the lump, be uniformly mixed; Second step, the glue sheet.The capsule material glue that taking-up prepares, be coated on smooth plate surface, makes thickness even, then, with the heating of the temperature of 90 ℃ of left and right, makes the surface moisture evaporation, and becoming has certain toughness, certain flexible cushion compound is arranged.The 3rd step, the compacting soft capsule.During small lot batch manufacture, with the manual compacting of pelleting mould; During production in enormous quantities, often adopt the automatic rotation rolling capsule machine to be produced.
2, dropping preparation method: dropping preparation method refers to by the method for the standby soft capsule of autocratic monarchy's mechanism.Should be noted formula, the viscosity of glue during making, and the density of all annex solutions and temperature.
In present embodiment, radix polygonati officinalis and ginseng are selected fresh goods or dry product, are preferably fresh goods, when selecting dry product, need to send out and process through bubble.
Comparative Examples 1
Radix polygonati officinalis and fresh ginseng are cleaned up, and the weight ratio according to Yu Zhu ︰ fresh ginseng=7 ︰ 3, take radix polygonati officinalis 14g and fresh ginseng 6g, extracts the mixture of radix polygonati officinalis and ginseng according to the processing step of water extraction, and the content that records polysaccharide in mixture is fresh weight 4.4%.
Embodiment 1
(1) radix polygonati officinalis and fresh ginseng are cleaned up, the weight ratio according to beautiful bamboo ︰ fresh ginseng=7 ︰ 3, take radix polygonati officinalis 14g and fresh ginseng 6g, with radix polygonati officinalis and fresh ginseng gross weight 10 times, adds distilled water, is crushed to 15 orders, obtains the mixture A of radix polygonati officinalis and fresh ginseng;
(2) weight ratio according to mixture A ︰ distilled water=1 ︰ 1 adds distilled water, crosses colloid mill, obtains latex B;
(3) latex B is warming up to 50 ℃, according to the mixture of latex B ︰ cellulase and hemicellulase=weight ratio of 1 ︰ 1000, adds the mixture of cellulase and hemicellulase, enzymolysis 60min, obtain enzymolysis product C;
In the mixture of described cellulase and hemicellulase, the weight ratio of cellulase and hemicellulase is 1 ︰ 1;
(4) weight ratio according to enzymolysis product C ︰ papain=1 ︰ 1000 adds papain, and enzymolysis 60min, obtain enzymolysis product D;
(5) enzymolysis product D is warming up to 80 ℃, water-bath 60min, obtain mixture E;
(6), by the mixture E filter cleaner, being evaporated to density is 1 ︰ 1.2, obtains the radix polygonati officinalis Radix Ginseng extractum;
(7) the radix polygonati officinalis Radix Ginseng extractum is made to soft capsule.
The content that records soluble polysaccharide in radix polygonati officinalis ginseng soft capsule finished product is 76.3%, with Comparative Examples 1 acquired results, compares, and polysaccharide extract rate has improved 68.2%.
Comparative Examples 2
Radix polygonati officinalis and fresh ginseng are cleaned up, and the weight ratio according to Yu Zhu ︰ fresh ginseng=2 ︰ 1, take radix polygonati officinalis 14g and fresh ginseng 7g, extracts the mixture of radix polygonati officinalis and ginseng according to the processing step of water extraction, and the content that records polysaccharide in mixture is fresh weight 4.1%.
Embodiment 2
(1) radix polygonati officinalis and fresh ginseng are cleaned up, the weight ratio according to beautiful bamboo ︰ fresh ginseng=2 ︰ 1, take radix polygonati officinalis 14g and fresh ginseng 7g, with radix polygonati officinalis and fresh ginseng gross weight 8 times, adds distilled water, is crushed to 13 orders, obtains the mixture A of radix polygonati officinalis and fresh ginseng;
(2) weight ratio according to mixture A ︰ distilled water=1 ︰ 0.1 adds distilled water, crosses colloid mill, obtains latex B;
(3) latex B is warming up to 40 ℃, according to the mixture of latex B ︰ cellulase and hemicellulase=weight ratio of 1 ︰ 100, adds the mixture of cellulase and hemicellulase, enzymolysis 50min, obtain enzymolysis product C;
In the mixture of described cellulase and hemicellulase, the weight ratio of cellulase and hemicellulase is 1 ︰ 1;
(4) weight ratio according to enzymolysis product C ︰ trypsase=1 ︰ 100 adds trypsase, and enzymolysis 70min, obtain enzymolysis product D;
(5) enzymolysis product D is warming up to 60 ℃, water-bath 50min, obtain mixture E;
(6), by the mixture E filter cleaner, being evaporated to density is 1 ︰ 1.1, obtains the radix polygonati officinalis Radix Ginseng extractum;
(7) the radix polygonati officinalis Radix Ginseng extractum is made to soft capsule.
The content that records soluble polysaccharide in radix polygonati officinalis ginseng soft capsule finished product is 72.5%, with Comparative Examples 2 acquired results, compares, and polysaccharide extract rate has improved 52.8%.
Comparative Examples 3
Radix polygonati officinalis and fresh ginseng are cleaned up, and the weight ratio according to Yu Zhu ︰ fresh ginseng=5 ︰ 1, take radix polygonati officinalis 15g and fresh ginseng 3g, extracts the mixture of radix polygonati officinalis and ginseng according to the processing step of water extraction, and the content that records polysaccharide in mixture is fresh weight 4.3%.
Embodiment 3
(1) radix polygonati officinalis and fresh ginseng are cleaned up, the weight ratio according to beautiful bamboo ︰ fresh ginseng=5 ︰ 1, take radix polygonati officinalis 15g and fresh ginseng 3g, with radix polygonati officinalis and fresh ginseng gross weight 12 times, adds distilled water, is crushed to 17 orders, obtains the mixture A of radix polygonati officinalis and fresh ginseng;
(2) weight ratio according to mixture A ︰ distilled water=1 ︰ 5 adds distilled water, crosses colloid mill, obtains latex B;
(3) latex B is warming up to 60 ℃, according to the mixture of latex B ︰ cellulase and hemicellulase=weight ratio of 1 ︰ 10000, adds the mixture of cellulase and hemicellulase, enzymolysis 70min, obtain enzymolysis product C;
In the mixture of described cellulase and hemicellulase, the weight ratio of cellulase and hemicellulase is 1 ︰ 1;
(4) weight ratio according to enzymolysis product C ︰ Proteinase K=1 ︰ 10000 adds Proteinase K, and enzymolysis 50min, obtain enzymolysis product D;
(5) enzymolysis product D is warming up to 100 ℃, water-bath 70min, obtain mixture E;
(6), by the mixture E filter cleaner, being evaporated to density is 1 ︰ 1.15, obtains the radix polygonati officinalis Radix Ginseng extractum;
(7) the radix polygonati officinalis Radix Ginseng extractum is made to soft capsule.
The content that records soluble polysaccharide in radix polygonati officinalis ginseng soft capsule finished product is 64.4%, with Comparative Examples 3 acquired results, compares, and polysaccharide extract rate has improved 50.1%.
Comparative Examples 4
Radix polygonati officinalis and fresh ginseng are cleaned up, and the weight ratio according to Yu Zhu ︰ fresh ginseng=1 ︰ 1, take radix polygonati officinalis 10g and fresh ginseng 10g, extracts the mixture of radix polygonati officinalis and ginseng according to the processing step of water extraction, and the content that records polysaccharide in mixture is fresh weight 3.8%.
Embodiment 4
(1) radix polygonati officinalis and fresh ginseng are cleaned up, the weight ratio according to beautiful bamboo ︰ fresh ginseng=1 ︰ 1, take radix polygonati officinalis 10g and fresh ginseng 10g, with radix polygonati officinalis and fresh ginseng gross weight 9 times, adds distilled water, is crushed to 14 orders, obtains the mixture A of radix polygonati officinalis and fresh ginseng;
(2) weight ratio according to mixture A ︰ distilled water=1 ︰ 3 adds distilled water, crosses colloid mill, obtains latex B;
(3) latex B is warming up to 55 ℃, according to the mixture of latex B ︰ cellulase and hemicellulase=weight ratio of 1 ︰ 5000, adds the mixture of cellulase and hemicellulase, enzymolysis 65min, obtain enzymolysis product C;
In the mixture of described cellulase and hemicellulase, the weight ratio of cellulase and hemicellulase is 1 ︰ 1;
(4) weight ratio according to enzymolysis product C ︰ chymotrypsin=1 ︰ 4000 adds chymotrypsin, and enzymolysis 55min, obtain enzymolysis product D;
(5) enzymolysis product D is warming up to 90 ℃, water-bath 65min, obtain mixture E;
(6), by the mixture E filter cleaner, being evaporated to density is 1 ︰ 1.2, obtains the radix polygonati officinalis Radix Ginseng extractum;
(7) the radix polygonati officinalis Radix Ginseng extractum is made to soft capsule.
The content that records soluble polysaccharide in radix polygonati officinalis ginseng soft capsule finished product is 72.3%, with Comparative Examples 4 acquired results, compares, and polysaccharide extract rate has improved 53.2%.
Comparative Examples 5
Radix polygonati officinalis and fresh ginseng are cleaned up, and the weight ratio according to Yu Zhu ︰ fresh ginseng=9 ︰ 1, take radix polygonati officinalis 18g and fresh ginseng 2g, extracts the mixture of radix polygonati officinalis and ginseng according to the processing step of water extraction, and the content that records polysaccharide in mixture is fresh weight 4.8%.
Embodiment 5
(1) radix polygonati officinalis and fresh ginseng are cleaned up, the weight ratio according to beautiful bamboo ︰ fresh ginseng=9 ︰ 1, take radix polygonati officinalis 18g and fresh ginseng 2g, with radix polygonati officinalis and fresh ginseng gross weight 11 times, adds distilled water, is crushed to 16 orders, obtains the mixture A of radix polygonati officinalis and fresh ginseng;
(2) weight ratio according to mixture A ︰ distilled water=1 ︰ 4 adds distilled water, crosses colloid mill, obtains latex B;
(3) latex B is warming up to 45 ℃, according to the mixture of latex B ︰ cellulase and hemicellulase=weight ratio of 1 ︰ 3000, adds the mixture of cellulase and hemicellulase, enzymolysis 55min, obtain enzymolysis product C;
In the mixture of described cellulase and hemicellulase, the weight ratio of cellulase and hemicellulase is 1 ︰ 1;
(4) weight ratio according to enzymolysis product C ︰ Collagenase=1 ︰ 6000 adds Collagenase, and enzymolysis 65min, obtain enzymolysis product D;
(5) enzymolysis product D is warming up to 85 ℃, water-bath 55min, obtain mixture E;
(6), by the mixture E filter cleaner, being evaporated to density is 1 ︰ 1.1, obtains the radix polygonati officinalis Radix Ginseng extractum;
(7) the radix polygonati officinalis Radix Ginseng extractum is made to soft capsule.
The content that records soluble polysaccharide in radix polygonati officinalis ginseng soft capsule finished product is 80.6%, with Comparative Examples 5 acquired results, compares, and polysaccharide extract rate has improved 64.8%.
Comparative Examples 6
Radix polygonati officinalis and fresh ginseng are cleaned up, and the weight ratio according to Yu Zhu ︰ fresh ginseng=6 ︰ 2.5, take radix polygonati officinalis 12g and fresh ginseng 5g, extracts the mixture of radix polygonati officinalis and ginseng according to the processing step of water extraction, and the content that records polysaccharide in mixture is fresh weight 4.2%.
Embodiment 6
(1) radix polygonati officinalis and fresh ginseng are cleaned up, the weight ratio according to beautiful bamboo ︰ fresh ginseng=6 ︰ 2.5, take radix polygonati officinalis 12g and fresh ginseng 5g, with radix polygonati officinalis and fresh ginseng gross weight 10 times, adds distilled water, is crushed to 14 orders, obtains the mixture A of radix polygonati officinalis and fresh ginseng;
(2) weight ratio according to mixture A ︰ distilled water=1 ︰ 2 adds distilled water, crosses colloid mill, obtains latex B;
(3) latex B is warming up to 60 ℃, according to the mixture of latex B ︰ cellulase and hemicellulase=weight ratio of 1 ︰ 7000, adds the mixture of cellulase and hemicellulase, enzymolysis 60min, obtain enzymolysis product C;
In the mixture of described cellulase and hemicellulase, the weight ratio of cellulase and hemicellulase is 1 ︰ 1;
(4) weight ratio according to enzymolysis product C ︰ papain=1 ︰ 8000 adds papain, and enzymolysis 60min, obtain enzymolysis product D;
(5) enzymolysis product D is warming up to 70 ℃, water-bath 60min, obtain mixture E;
(6), by the mixture E filter cleaner, being evaporated to density is 1 ︰ 1.15, obtains the radix polygonati officinalis Radix Ginseng extractum;
(7) the radix polygonati officinalis Radix Ginseng extractum is made to soft capsule.
The content that records soluble polysaccharide in radix polygonati officinalis ginseng soft capsule finished product is 73.9%, with Comparative Examples 5 acquired results, compares, and polysaccharide extract rate has improved 50.1%.
Comparative Examples 7
Radix polygonati officinalis and fresh ginseng are cleaned up, and the weight ratio according to Yu Zhu ︰ fresh ginseng=7 ︰ 1, take radix polygonati officinalis 17.5g and fresh ginseng 2.5g, extracts the mixture of radix polygonati officinalis and ginseng according to the processing step of water extraction, and the content that records polysaccharide in mixture is fresh weight 4.6%.
Embodiment 7
(1) radix polygonati officinalis and fresh ginseng are cleaned up, the weight ratio according to beautiful bamboo ︰ fresh ginseng=7 ︰ 1, take radix polygonati officinalis 17.5g and fresh ginseng 2.5g, with radix polygonati officinalis and fresh ginseng gross weight 10 times, adds distilled water, is crushed to 15 orders, obtains the mixture A of radix polygonati officinalis and fresh ginseng;
(2) weight ratio according to mixture A ︰ distilled water=1 ︰ 0.8 adds distilled water, crosses colloid mill, obtains latex B;
(3) latex B is warming up to 60 ℃, according to the mixture of latex B ︰ cellulase and hemicellulase=weight ratio of 1 ︰ 4000, adds the mixture of cellulase and hemicellulase, enzymolysis 55min, obtain enzymolysis product C;
In the mixture of described cellulase and hemicellulase, the weight ratio of cellulase and hemicellulase is 1 ︰ 1;
(4) weight ratio according to enzymolysis product C ︰ trypsase=1 ︰ 2000 adds trypsase, and enzymolysis 50min, obtain enzymolysis product D;
(5) enzymolysis product D is warming up to 75 ℃, water-bath 65min, obtain mixture E;
(6), by the mixture E filter cleaner, being evaporated to density is 1 ︰ 1.1, obtains the radix polygonati officinalis Radix Ginseng extractum;
(7) the radix polygonati officinalis Radix Ginseng extractum is made to soft capsule.
The content that records soluble polysaccharide in radix polygonati officinalis ginseng soft capsule finished product is 79.8%, with Comparative Examples 5 acquired results, compares, and polysaccharide extract rate has improved 51.5%.
Comparative Examples 8
Radix polygonati officinalis and fresh ginseng are cleaned up, and the weight ratio according to Yu Zhu ︰ fresh ginseng=4 ︰ 1, take radix polygonati officinalis 16g and fresh ginseng 4g, extracts the mixture of radix polygonati officinalis and ginseng according to the processing step of water extraction, and the content that records polysaccharide in mixture is fresh weight 4.3%.
Embodiment 8
(1) radix polygonati officinalis and fresh ginseng are cleaned up, the weight ratio according to beautiful bamboo ︰ fresh ginseng=4 ︰ 1, take radix polygonati officinalis 16g and fresh ginseng 4g, with radix polygonati officinalis and fresh ginseng gross weight 8 times, adds distilled water, is crushed to 14 orders, obtains the mixture A of radix polygonati officinalis and fresh ginseng;
(2) weight ratio according to mixture A ︰ distilled water=1 ︰ 1 adds distilled water, crosses colloid mill, obtains latex B;
(3) latex B is warming up to 45 ℃, according to the mixture of latex B ︰ cellulase and hemicellulase=weight ratio of 1 ︰ 2000, adds the mixture of cellulase and hemicellulase, enzymolysis 65min, obtain enzymolysis product C;
In the mixture of described cellulase and hemicellulase, the weight ratio of cellulase and hemicellulase is 1 ︰ 1;
(4) weight ratio according to enzymolysis product C ︰ trypsase=1 ︰ 7000 adds trypsase, and enzymolysis 60min, obtain enzymolysis product D;
(5) enzymolysis product D is warming up to 80 ℃, water-bath 65min, obtain mixture E;
(6), by the mixture E filter cleaner, being evaporated to density is 1 ︰ 1.2, obtains the radix polygonati officinalis Radix Ginseng extractum;
(7) the radix polygonati officinalis Radix Ginseng extractum is made to soft capsule.
The content that records soluble polysaccharide in radix polygonati officinalis ginseng soft capsule finished product is 78.1%, with Comparative Examples 5 acquired results, compares, and polysaccharide extract rate has improved 62.1%.
Obviously, above-described embodiment is only for example clearly is described, and is not the restriction to embodiment; For the person of an ordinary skill in the technical field, can also make other changes in different forms on the basis of the above description; Here exhaustive without also giving all embodiments; And the apparent variation of being extended out thus or change are still among the protection domain in the invention.
Claims (10)
1. the preparation method of radix polygonati officinalis ginseng soft capsule, is characterized in that, condition and the step of the method are as follows:
(1) weight ratio according to beautiful bamboo ︰ fresh ginseng=1 ︰ 1～9 ︰ 1 takes radix polygonati officinalis and fresh ginseng, with radix polygonati officinalis and fresh ginseng gross weight 8～12 times, adds distilled water, is crushed to 13～17 orders, obtains the mixture A of radix polygonati officinalis and fresh ginseng;
(2) weight ratio according to mixture A ︰ distilled water=1 ︰ 0.1～1 ︰ 5 adds distilled water, crosses colloid mill, obtains latex B;
(3) latex B is warming up to 40～60 ℃, according to the weight ratio of the mixture of latex B ︰ cellulase and hemicellulase=1 ︰ 100～1 ︰ 10000, adds the mixture of cellulase and hemicellulase, enzymolysis 50～70min, obtain enzymolysis product C;
In the mixture of described cellulase and hemicellulase, the weight ratio of cellulase and hemicellulase is 1 ︰ 1;
(4) weight ratio according to enzymolysis product C ︰ protease=1 ︰ 100～1 ︰ 10000 adds protease, and enzymolysis 50～70min, obtain enzymolysis product D;
(5) enzymolysis product D is warming up to 60～100 ℃, water-bath 50～70min, obtain mixture E;
(6), by the mixture E filter cleaner, being evaporated to density is 1 ︰ 1.1～1 ︰ 1.2, obtains the radix polygonati officinalis Radix Ginseng extractum;
(7) the radix polygonati officinalis Radix Ginseng extractum is made to radix polygonati officinalis ginseng soft capsule.
2. the preparation method of radix polygonati officinalis ginseng soft capsule according to claim 1, is characterized in that, in step (1), according to the weight ratio of Yu Zhu ︰ fresh ginseng=2 ︰ 1～5 ︰ 1, takes radix polygonati officinalis and fresh ginseng.
3. the preparation method of radix polygonati officinalis ginseng soft capsule according to claim 1, is characterized in that, in step (1), according to the weight ratio of Yu Zhu ︰ fresh ginseng=7 ︰ 3, takes radix polygonati officinalis and fresh ginseng.
4. the preparation method of radix polygonati officinalis ginseng soft capsule according to claim 1, is characterized in that, in step (1), radix polygonati officinalis and fresh ginseng is crushed to 15 orders.
5. the preparation method of radix polygonati officinalis ginseng soft capsule according to claim 1, is characterized in that, in step (2), according to the weight ratio of mixture A ︰ distilled water=1 ︰ 1, adds distilled water.
6. the preparation method of radix polygonati officinalis ginseng soft capsule according to claim 1, is characterized in that, in step (3), latex B is warming up to 50 ℃.
7. the preparation method of radix polygonati officinalis ginseng soft capsule according to claim 1, is characterized in that, in step (3), according to the mixture of latex B ︰ cellulase and hemicellulase=weight ratio of 1 ︰ 1000, adds the mixture of cellulase and hemicellulase.
8. the preparation method of radix polygonati officinalis ginseng soft capsule according to claim 1, is characterized in that, in step (4), described protease is trypsase, Proteinase K, papain, chymotrypsin or Collagenase.
9. the preparation method of radix polygonati officinalis ginseng soft capsule according to claim 1, is characterized in that, in step (4), according to the weight ratio of enzymolysis product C ︰ protease=1 ︰ 1000, adds protease.
10. the preparation method of radix polygonati officinalis ginseng soft capsule according to claim 1, is characterized in that, in step (5), enzymolysis product D is warming up to 80 ℃.
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104026706B (en) * | 2014-06-27 | 2015-10-14 | 广西健美乐食品有限公司 | A kind of preparation method of red bamboo liquid |
| CN104984331A (en) * | 2015-07-08 | 2015-10-21 | 徐培良 | Solution preparation using biological active multienzyme to restore pancreatic beta-cells and preparation method thereof |
| CN108969671A (en) * | 2018-08-29 | 2018-12-11 | 长白山制药股份有限公司 | It is a kind of with the pharmaceutical composition and preparation method thereof for improving immunity of organism, increasing radiation-resisting functional |
| CN110384757A (en) * | 2018-04-19 | 2019-10-29 | 雅安迅康药业有限公司 | A kind of pressed candy and purposes improving Qi deficiency physique |
| CN113440587A (en) * | 2021-07-27 | 2021-09-28 | 东莞市尚慈生物医药科技有限公司 | Traditional Chinese medicine composition and application thereof in preparation of refreshing medicine |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101585885A (en) * | 2009-06-16 | 2009-11-25 | 西北农林科技大学 | Method for preparing polygonatum odoratum polysaccharide |
-
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101585885A (en) * | 2009-06-16 | 2009-11-25 | 西北农林科技大学 | Method for preparing polygonatum odoratum polysaccharide |
Non-Patent Citations (1)
| Title |
|---|
| 许丽丽 等: "玉竹多糖的研究进展", 《中药材》 * |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104026706B (en) * | 2014-06-27 | 2015-10-14 | 广西健美乐食品有限公司 | A kind of preparation method of red bamboo liquid |
| CN104984331A (en) * | 2015-07-08 | 2015-10-21 | 徐培良 | Solution preparation using biological active multienzyme to restore pancreatic beta-cells and preparation method thereof |
| CN110384757A (en) * | 2018-04-19 | 2019-10-29 | 雅安迅康药业有限公司 | A kind of pressed candy and purposes improving Qi deficiency physique |
| CN108969671A (en) * | 2018-08-29 | 2018-12-11 | 长白山制药股份有限公司 | It is a kind of with the pharmaceutical composition and preparation method thereof for improving immunity of organism, increasing radiation-resisting functional |
| CN113440587A (en) * | 2021-07-27 | 2021-09-28 | 东莞市尚慈生物医药科技有限公司 | Traditional Chinese medicine composition and application thereof in preparation of refreshing medicine |
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