CN103492389B - 用作激酶抑制剂的吡唑并[4,3-d]嘧啶 - Google Patents
用作激酶抑制剂的吡唑并[4,3-d]嘧啶 Download PDFInfo
- Publication number
- CN103492389B CN103492389B CN201280019429.4A CN201280019429A CN103492389B CN 103492389 B CN103492389 B CN 103492389B CN 201280019429 A CN201280019429 A CN 201280019429A CN 103492389 B CN103492389 B CN 103492389B
- Authority
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- China
- Prior art keywords
- pyrazolo
- base
- pyrimidine
- phenyl
- amine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 0 *Nc1c(C(N)=O)[n]nc1 Chemical compound *Nc1c(C(N)=O)[n]nc1 0.000 description 2
- CTVRFJSJXPCPFX-UHFFFAOYSA-N CC(C)c1c[n](cccc2)c2n1 Chemical compound CC(C)c1c[n](cccc2)c2n1 CTVRFJSJXPCPFX-UHFFFAOYSA-N 0.000 description 1
- TVSMLBGFGKLKOO-UHFFFAOYSA-N CC1CCN(C)CC1 Chemical compound CC1CCN(C)CC1 TVSMLBGFGKLKOO-UHFFFAOYSA-N 0.000 description 1
- IQISOVKPFBLQIQ-UHFFFAOYSA-N Cc(cc(cc1)OC)c1OC Chemical compound Cc(cc(cc1)OC)c1OC IQISOVKPFBLQIQ-UHFFFAOYSA-N 0.000 description 1
- PQNUIDJXNXPHGG-UHFFFAOYSA-N Cc(cc1)cnc1N1CCCC1 Chemical compound Cc(cc1)cnc1N1CCCC1 PQNUIDJXNXPHGG-UHFFFAOYSA-N 0.000 description 1
- GYPMBQZAVBFUIZ-UHFFFAOYSA-N Cc(cc1OC)ccc1OC Chemical compound Cc(cc1OC)ccc1OC GYPMBQZAVBFUIZ-UHFFFAOYSA-N 0.000 description 1
- QWVGKYWNOKOFNN-UHFFFAOYSA-N Cc(cccc1)c1O Chemical compound Cc(cccc1)c1O QWVGKYWNOKOFNN-UHFFFAOYSA-N 0.000 description 1
- QENGPZGAWFQWCZ-UHFFFAOYSA-N Cc1c[s]cc1 Chemical compound Cc1c[s]cc1 QENGPZGAWFQWCZ-UHFFFAOYSA-N 0.000 description 1
- HDMDXJAWWCMBSV-UHFFFAOYSA-N Cc1cc(N2CCOCC2)ccc1 Chemical compound Cc1cc(N2CCOCC2)ccc1 HDMDXJAWWCMBSV-UHFFFAOYSA-N 0.000 description 1
- OSIGJGFTADMDOB-UHFFFAOYSA-N Cc1cc(OC)ccc1 Chemical compound Cc1cc(OC)ccc1 OSIGJGFTADMDOB-UHFFFAOYSA-N 0.000 description 1
- XQQBUAPQHNYYRS-UHFFFAOYSA-N Cc1ccc[s]1 Chemical compound Cc1ccc[s]1 XQQBUAPQHNYYRS-UHFFFAOYSA-N 0.000 description 1
- LONDBHTYIYKOCM-UHFFFAOYSA-N Cc1cccc(-c2cnccc2)c1 Chemical compound Cc1cccc(-c2cnccc2)c1 LONDBHTYIYKOCM-UHFFFAOYSA-N 0.000 description 1
- YXFVVABEGXRONW-UHFFFAOYSA-N Cc1ccccc1 Chemical compound Cc1ccccc1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 1
- FKNQCJSGGFJEIZ-UHFFFAOYSA-N Cc1ccncc1 Chemical compound Cc1ccncc1 FKNQCJSGGFJEIZ-UHFFFAOYSA-N 0.000 description 1
- XKVUYEYANWFIJX-UHFFFAOYSA-N Cc1n[nH]cc1 Chemical compound Cc1n[nH]cc1 XKVUYEYANWFIJX-UHFFFAOYSA-N 0.000 description 1
- LDZYRENCLPUXAX-UHFFFAOYSA-N Cc1nc(cccc2)c2[nH]1 Chemical compound Cc1nc(cccc2)c2[nH]1 LDZYRENCLPUXAX-UHFFFAOYSA-N 0.000 description 1
- PJQIBTFOXWGAEN-UHFFFAOYSA-N Cc1nc(cccc2)c2[n]1C Chemical compound Cc1nc(cccc2)c2[n]1C PJQIBTFOXWGAEN-UHFFFAOYSA-N 0.000 description 1
- DXYYSGDWQCSKKO-UHFFFAOYSA-N Cc1nc(cccc2)c2[s]1 Chemical compound Cc1nc(cccc2)c2[s]1 DXYYSGDWQCSKKO-UHFFFAOYSA-N 0.000 description 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Dermatology (AREA)
- Ophthalmology & Optometry (AREA)
- Pain & Pain Management (AREA)
- Otolaryngology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Diabetes (AREA)
- Cardiology (AREA)
- Transplantation (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161517582P | 2011-04-21 | 2011-04-21 | |
| US61/517,582 | 2011-04-21 | ||
| PCT/EP2012/001737 WO2012143144A1 (en) | 2011-04-21 | 2012-04-23 | Pyrazolo [4, 3-d] pyrimidines useful as kinase inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103492389A CN103492389A (zh) | 2014-01-01 |
| CN103492389B true CN103492389B (zh) | 2016-09-14 |
Family
ID=46017783
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201280019429.4A Active CN103492389B (zh) | 2011-04-21 | 2012-04-23 | 用作激酶抑制剂的吡唑并[4,3-d]嘧啶 |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US9802937B2 (https=) |
| EP (1) | EP2699579B1 (https=) |
| JP (1) | JP6222776B2 (https=) |
| KR (1) | KR101649611B1 (https=) |
| CN (1) | CN103492389B (https=) |
| AP (1) | AP2013007253A0 (https=) |
| AU (1) | AU2012244550C1 (https=) |
| BR (1) | BR112013026521A2 (https=) |
| CA (1) | CA2831634C (https=) |
| CL (1) | CL2013003051A1 (https=) |
| CO (1) | CO6831982A2 (https=) |
| CR (1) | CR20130536A (https=) |
| CU (1) | CU20130143A7 (https=) |
| EA (1) | EA029040B1 (https=) |
| EC (1) | ECSP13012982A (https=) |
| GT (1) | GT201300255A (https=) |
| IL (1) | IL228968A (https=) |
| MA (1) | MA35124B1 (https=) |
| MX (1) | MX363696B (https=) |
| PE (1) | PE20140928A1 (https=) |
| PH (1) | PH12013502185A1 (https=) |
| SG (1) | SG194549A1 (https=) |
| TN (1) | TN2013000419A1 (https=) |
| TW (1) | TWI606049B (https=) |
| WO (1) | WO2012143144A1 (https=) |
| ZA (1) | ZA201307839B (https=) |
Families Citing this family (62)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2691399B1 (en) * | 2011-03-28 | 2016-07-13 | F.Hoffmann-La Roche Ag | Thiazolopyrimidine compounds |
| UA111841C2 (uk) | 2011-04-21 | 2016-06-24 | Гіліад Сайєнсіз, Інк. | Сполуки бензотіазолу та їх фармацевтичне застосування |
| AP2013007253A0 (en) | 2011-04-21 | 2013-11-30 | Origenis Gmbh | Pyrazolo [4,3-D] pyrimidines useful as kinase inhibitors |
| US9284323B2 (en) | 2012-01-04 | 2016-03-15 | Gilead Sciences, Inc. | Naphthalene acetic acid derivatives against HIV infection |
| US9376392B2 (en) | 2012-01-04 | 2016-06-28 | Gilead Sciences, Inc. | 2-(tert-butoxy)-2-(7-methylquinolin-6-yl) acetic acid derivatives for treating AIDS |
| AR090650A1 (es) | 2012-04-12 | 2014-11-26 | Alcon Res Ltd | Tratamiento para respuestas inflamatorias inducidas por microbios en el ojo |
| US20120323214A1 (en) * | 2012-05-16 | 2012-12-20 | Totada R Shantha | Alzheimer's disease treatment with multiple therapeutic agents delivered to the olfactory region through a special delivery catheter and iontophoresis |
| EP2867236B1 (en) | 2012-06-29 | 2017-06-14 | Pfizer Inc | Novel 4-(substituted-amino)-7h-pyrrolo[2,3-d]pyrimidines as lrrk2 inhibitors |
| WO2014060112A1 (en) * | 2012-10-19 | 2014-04-24 | Origenis Gmbh | Pyrazolo[4,3-d]pyrimidines as kinase inhibitors |
| WO2014134774A1 (en) | 2013-03-04 | 2014-09-12 | Merck Sharp & Dohme Corp. | Compounds inhibiting leucine-rich repeat kinase enzyme activity |
| WO2014134776A1 (en) | 2013-03-04 | 2014-09-12 | Merck Sharp & Dohme Corp. | Compounds inhibiting leucine-rich repeat kinase enzyme activity |
| WO2014134772A1 (en) | 2013-03-04 | 2014-09-12 | Merck Sharp & Dohme Corp. | Compounds inhibiting leucine-rich repeat kinase enzyme activity |
| WO2014137728A1 (en) | 2013-03-04 | 2014-09-12 | Merck Sharp & Dohme Corp. | Compounds inhibiting leucine-rich repeat kinase enzyme activity |
| TW201534597A (zh) | 2013-06-20 | 2015-09-16 | Ab Science | 作為選擇性蛋白質激酶抑制劑之苯并咪唑衍生物 |
| US9718818B2 (en) | 2013-08-22 | 2017-08-01 | Merck Sharp & Dohme Corp. | Compounds inhibiting leucine-rich repeat kinase enzyme activity |
| WO2015057945A1 (en) | 2013-10-18 | 2015-04-23 | Indiana University Research And Technology Corporation | Hepatitis b viral assembly effectors |
| EP3083618B1 (en) | 2013-12-17 | 2018-02-21 | Pfizer Inc | Novel 3,4-disubstituted-1h-pyrrolo[2,3-b]pyridines and 4,5-disubstituted-7h-pyrrolo[2,3-c]pyridazines as lrrk2 inhibitors |
| RU2016134751A (ru) | 2014-01-29 | 2018-03-02 | Глэксосмитклайн Интеллекчуал Проперти Дивелопмент Лимитед | Соединения |
| MA39219B1 (fr) | 2014-01-29 | 2018-11-30 | Glaxosmithkline Ip Dev Ltd | Nouveaux composés inhibiteurs de la kinase lrrk2 utilisés pour le traitement du parkinson, de l’alzheimer et de la sclérose latérale amyotrophique |
| WO2015162515A1 (en) | 2014-04-25 | 2015-10-29 | Pfizer Inc. | Heteroaromatic compounds and their use as dopamine d1 ligands |
| US10004751B2 (en) | 2014-07-10 | 2018-06-26 | The J. David Gladstone Institutes | Compositions and methods for treating Dengue virus infection |
| CN107801397B (zh) | 2015-02-13 | 2021-07-30 | 达纳－法伯癌症研究所公司 | Lrrk2抑制剂及其制备和使用方法 |
| CA2982811A1 (en) | 2015-04-17 | 2016-10-20 | Indiana University Research And Technology Corporation | Hepatitis b viral assembly effectors |
| US10729691B2 (en) | 2015-06-26 | 2020-08-04 | Kadmon Corporation, Llc | Treatment of infectious diseases with glucose uptake inhibitors |
| JP2018518518A (ja) | 2015-06-26 | 2018-07-12 | カドモン コーポレイション，リミティド ライアビリティ カンパニー | グルコース取り込み阻害剤 |
| RU2722149C1 (ru) | 2015-09-14 | 2020-05-27 | Пфайзер Инк. | Новые производные имидазо[4,5-c] хинолинов и имидазо[4,5-c][1,5] нафтиридинов в качестве ингибиторов LRRK2 |
| US9762007B2 (en) | 2016-02-10 | 2017-09-12 | Dish Network L.L.C. | Push on connector |
| WO2018049214A1 (en) | 2016-09-09 | 2018-03-15 | Incyte Corporation | Pyrazolopyridine derivatives as hpk1 modulators and uses thereof for the treatment of cancer |
| US20180072741A1 (en) | 2016-09-09 | 2018-03-15 | Incyte Corporation | Pyrazolopyrimidine compounds and uses thereof |
| US10280164B2 (en) | 2016-09-09 | 2019-05-07 | Incyte Corporation | Pyrazolopyridone compounds and uses thereof |
| CN115819417A (zh) | 2016-09-09 | 2023-03-21 | 因赛特公司 | 作为hpk1调节剂的吡唑并吡啶衍生物及其用于治疗癌症的用途 |
| RU2019112740A (ru) | 2016-09-30 | 2020-11-02 | АСАНА БАЙОСАЙЕНСИЗ, ЭлЭлСи | P2x3 и/или p2x2/3 соединения и способы |
| CN106620315A (zh) * | 2016-11-17 | 2017-05-10 | 郑州郑先医药科技有限公司 | 一种用于治疗风湿病的药物组合物 |
| CN106667990A (zh) * | 2016-11-17 | 2017-05-17 | 郑州郑先医药科技有限公司 | 一种治疗风湿病的药物 |
| US20180153922A1 (en) | 2016-12-06 | 2018-06-07 | New York Society For The Ruptured And Crippled Maintaining The Hospital For Special Surgery | Inhibition of expansion and function of pathogenic age-associated b cells and use for the prevention and treatment of autoimmune disease |
| CN106580974A (zh) * | 2016-12-06 | 2017-04-26 | 郑州郑先医药科技有限公司 | 一种治疗脊髓损伤的西药组合物及其应用 |
| US12539297B2 (en) | 2017-02-07 | 2026-02-03 | Oncocross Co., Ltd. | Composition for inhibiting cancer metastasis and treating cancer |
| JP6900067B2 (ja) * | 2017-02-07 | 2021-07-07 | オンコクロス カンパニー，リミテッド | 癌の転移抑制および治療用組成物 |
| WO2018152220A1 (en) | 2017-02-15 | 2018-08-23 | Incyte Corporation | Pyrazolopyridine compounds and uses thereof |
| MX2019012431A (es) | 2017-04-21 | 2020-08-03 | Ikena Oncology Inc | Inhibidores del receptor de hidrocarburos de arilo (ahr) de indol y usos de los mismos. |
| US10722495B2 (en) | 2017-09-08 | 2020-07-28 | Incyte Corporation | Cyanoindazole compounds and uses thereof |
| CN108178760B (zh) * | 2017-12-27 | 2020-02-18 | 安徽医科大学 | 一种嘧啶并吡唑杂环化合物、制备方法、用途 |
| US10752635B2 (en) | 2018-02-20 | 2020-08-25 | Incyte Corporation | Indazole compounds and uses thereof |
| EP3755703B1 (en) | 2018-02-20 | 2022-05-04 | Incyte Corporation | N-(phenyl)-2-(phenyl)pyrimidine-4-carboxamide derivatives and related compounds as hpk1 inhibitors for treating cancer |
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