CN103491778B - 1‑甲基‑n‑(2，6‑二甲苯基)‑2‑哌啶甲酰胺的皮肤用药物组合物及其使用方法 - Google Patents

1‑甲基‑n‑(2，6‑二甲苯基)‑2‑哌啶甲酰胺的皮肤用药物组合物及其使用方法 Download PDF

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CN103491778B
CN103491778B CN201180027559.8A CN201180027559A CN103491778B CN 103491778 B CN103491778 B CN 103491778B CN 201180027559 A CN201180027559 A CN 201180027559A CN 103491778 B CN103491778 B CN 103491778B
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mepivacaine
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CN103491778A (zh
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N·巴布尔
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7015—Drug-containing film-forming compositions, e.g. spray-on
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4458—Non condensed piperidines, e.g. piperocaine only substituted in position 2, e.g. methylphenidate
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    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
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    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
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    • A—HUMAN NECESSITIES
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    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
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    • A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
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    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
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    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
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  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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CN201180027559.8A 2010-04-13 2011-04-13 1‑甲基‑n‑(2，6‑二甲苯基)‑2‑哌啶甲酰胺的皮肤用药物组合物及其使用方法 Active CN103491778B (zh)

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CN201710323695.0A CN107115326B (zh) 2010-04-13 2011-04-13 1-甲基-n-(2,6-二甲苯基)-2-哌啶甲酰胺的皮肤用药物组合物及其使用方法

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US32378010P 2010-04-13 2010-04-13
US61/323,780 2010-04-13
PCT/US2011/032381 WO2011130455A1 (en) 2010-04-13 2011-04-13 Dermal pharmaceutical compositions of 1-methyl-2',6'-pipecoloxylidide and method of use

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CN201710323695.0A Division CN107115326B (zh) 2010-04-13 2011-04-13 1-甲基-n-(2,6-二甲苯基)-2-哌啶甲酰胺的皮肤用药物组合物及其使用方法

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CN103491778A CN103491778A (zh) 2014-01-01
CN103491778B true CN103491778B (zh) 2017-05-31

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CN201180027559.8A Active CN103491778B (zh) 2010-04-13 2011-04-13 1‑甲基‑n‑(2，6‑二甲苯基)‑2‑哌啶甲酰胺的皮肤用药物组合物及其使用方法

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US (1) US11607407B2 (enExample)
EP (1) EP2557924B1 (enExample)
JP (1) JP5927506B2 (enExample)
KR (3) KR101955175B1 (enExample)
CN (2) CN107115326B (enExample)
AU (1) AU2011239636A1 (enExample)
CA (1) CA2796575C (enExample)
DK (1) DK2557924T3 (enExample)
WO (1) WO2011130455A1 (enExample)

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WO2022007917A1 (zh) * 2020-07-10 2022-01-13 江苏恒瑞医药股份有限公司 一种含麻醉药物活性成分的透皮制剂及其制备方法

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CN102670815B (zh) * 2011-03-14 2013-08-07 王力 一种治疗脚气的外用中药
FR2983731B1 (fr) * 2011-12-07 2014-04-25 Univ Paris Descartes Emulsions topiques a base de melanges eutectiques d'anesthesiques locaux et d'acide gras
US8663177B1 (en) * 2012-09-28 2014-03-04 Anal-Gesic LLC Medication delivery, dosing and safety devices, systems and kits
WO2015053878A1 (en) * 2013-10-11 2015-04-16 Teikoku Pharma Usa, Inc. Topical sphingosine-1-phosphate receptor agonist formulations and methods of using the same
EP2921184A1 (de) * 2014-03-19 2015-09-23 LTS LOHMANN Therapie-Systeme AG Überpflaster mit verbesserter Verträglichkeit und einer langen Haftungsdauer und Verfahren zu seiner Herstellung
CN104107210B (zh) * 2014-05-21 2017-11-17 安徽康缘药业有限公司 一种抗疲劳微乳液及其制备方法
CN105902494A (zh) * 2016-06-07 2016-08-31 东莞市麦亘生物科技有限公司 一种新型气冷喷雾剂及其使用方法
JP6801554B2 (ja) * 2017-03-29 2020-12-16 東洋インキＳｃホールディングス株式会社 皮膚貼付用粘着剤、皮膚用貼付剤、および剥離用シート状部材付き皮膚用貼付剤の製造方法
CN111315438B (zh) * 2017-08-10 2022-09-27 爱肤柔生命科学公司 经皮药物递送系统
BR112020003022A2 (pt) * 2017-12-26 2020-08-25 Hirotaro Fukuoka composição farmacêutica para o uso no crescimento de cabelo, modificação do couro cabeludo ou pele, cicatrização de uma ferida, promoção da osteogênese ou modificação do cabelo
CN112915072A (zh) * 2021-03-31 2021-06-08 重庆彭铿生物科技有限公司 一种用于骨质增生的膏药
KR20230170008A (ko) * 2021-04-09 2023-12-18 다우 실리콘즈 코포레이션 무용매형 폴리오가노실록산 펠릿 및 실리콘 감압 접착제 베이스의 수성 분산액의 제조 방법
WO2024062423A1 (en) * 2022-09-21 2024-03-28 Masek Josef Oromucosal film compositions
WO2025175174A1 (en) * 2024-02-14 2025-08-21 The Children's Medical Center Corporation 2'-6'-pipecoloxylidide as a sensory-selective anesthetic

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