CN103479735A - Compound relieving immunosuppression of pigs and application thereof - Google Patents
Compound relieving immunosuppression of pigs and application thereof Download PDFInfo
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- CN103479735A CN103479735A CN201310421620.8A CN201310421620A CN103479735A CN 103479735 A CN103479735 A CN 103479735A CN 201310421620 A CN201310421620 A CN 201310421620A CN 103479735 A CN103479735 A CN 103479735A
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Abstract
The invention discloses a compound relieving immunosuppression of pigs and the application of the compound. The compound comprises astragalus polysaccharide, epimedium extract, glossy privet fruit extract, fructus psoraleae extract, bicarb, butafosfan and Victim B12. When the compound serves as a feed additive and is added to feed and applied to immunosuppression of the pigs, the immunosuppression of the pigs can be effectively relieved, and disease resistance performance of the pigs and vaccine immune effect can be improved.
Description
Technical field
The present invention relates to a kind of alleviation pig immunosuppressant complex and application thereof, belong to field of veterinary.
Background technology
In the aspect fast developments such as breed improvement, cultivation scale, trophic level, epidemic disease health care prevention and control and the degree of specialization of raising pigs, also be faced with great puzzlement along with China's pig industry.Be mainly manifested in the continuous situation about improving of cultivating condition, the level of production does not but obtain corresponding raising, wherein maximum problem is the high rate of epidemic disease, and cause epidemic disease main cause occurred frequently, it is immunosuppressant, affected the immune effect of vaccine, make the great epidemic disease of pig clinically be difficult to control, vicious cycle even occurs, seriously restricted pig industry production.
Also well do not eliminate at present or alleviation pig immunosuppressant ways and means.Main method commonly used is to use the Chinese herbal medicine of immunostimulant, functional peptide class, functional amino etc.
Summary of the invention
The present invention is directed in prior art that to control pig immunosuppressant effect of drugs undesirable, purpose is to be to provide a kind of can effectively alleviate pig immunosuppressant complex.
Another object of the present invention is the application that is to provide a kind of described complex, is added on the stress that can effectively eliminate pig in the full price pig feed using described complex as feed additive and alleviates its immunosuppressant effect, improves the resistance of its body.
The invention provides a kind of alleviation pig immunosuppressant complex, this complex comprises following mass component:
Described complex also comprises mcg vitamin B12, and mass parts is 0.000010～0.000025 part.
The stem and leaf that described Herba Epimedii extract is Herba Epimedii and/or the extract of root, wherein, the quality percentage composition of icariine >=98%; Herba Epimedii comprises Radix Berberidis Amurensis plant Herba Epimedii, arrow leaf Herba Epimedii or pubescence Herba Epimedii; Described Herba Epimedii extract can be bought the companies such as Xi'an brilliant development in science and technology company limited difficult to understand, Dalian Hong Jiu International Trading Company Ltd or Xi'an Chang Yue plant chemical industry company limited.
The extract that described Fructus Ligustri Lucidi extract is Oleaceae Ligustrum plant Fructus Ligustri Lucidi mature fruit, wherein, the mass content of specnuezhenside is not less than 0.40%, and oleanolic acid and ursolic acid gross mass content are not less than 1%.
Described astragalus polysaccharides purity is not less than 90wt%, and mass percent is not less than 90%; Described astragalus polysaccharides is the root extract of Radix Astagali or Radix Astragali, mainly comprises the water solublity heteropolysaccharides such as sugar such as hexuronic acid, glucose, fructose, rhamnose, arabinose, galacturonic acid and glucuronic acid; Described astragalus polysaccharides can be bought in Jiangxi Kang Shengtang pharmaceutcal corporation, Ltd, Sichuan with safe plant chemical industry company limited, source, the world, Shaanxi bio tech ltd, the Tianjin grand Medicines and Health Product company limited of China or Zhengzhou Yi Yin plant material company limited.
The extract of the dry mature fruit that described Fructus Psoraleae extract is legumes psoraleae, wherein, the gross mass content of psoralen and isopsorapen is not less than 50%; Fructus Psoraleae extract can be bought and be full of medical company limited in Xi'an Chang Yue plant chemical industry company limited, Xi'an brilliant development in science and technology company limited difficult to understand or Xi'an.
The present invention also provides a kind of application of described complex, and this application is to be applied to alleviate the immunosuppressant of pig using described complex as pig feed additive.
Described complex is added in the pig complete feed.
The addition of described complex in the pig complete feed is 0.4～0.7wt%.
The addition of described complex in the pig complete feed is: astragalus polysaccharides 0.2～0.3 kg/ton, Herba Epimedii extract 0.5～1 kg/ton, Fructus Ligustri Lucidi extract 0.5～1 kg/ton, Fructus Psoraleae extract 1～2 kg/ton, sodium bicarbonate 2～5 kg/ton, butafosfan 0.01～0.02 kg/ton, vitamin B12 0.010～0.025 gram/ton.
The immunosuppressant of described alleviation pig is by allowing the pig edible complete feed realization in 7～17 days of having added described complex continuously.
The preparation method of alleviation of the present invention pig immunosuppressant complex: after by the mass parts ratio of component, butafosfan and vitamin B12 being stirred, add successively astragalus polysaccharides, Herba Epimedii extract, Fructus Ligustri Lucidi extract, Fructus Psoraleae extract and sodium bicarbonate in the gained mixture, stir after often adding a component, obtain a kind of alleviation pig immunosuppressant complex.
Beneficial effect of the present invention: alleviation pig immunosuppressant complex of the present invention is to use first composite the obtaining such as Chinese herbal medicine effective ingredients, inorganic matter and organophosphor supplement with unique function, there is the stress that can effectively eliminate pig, alleviate its immunosuppressant effect, and curative effect is certain, be difficult for again producing the characteristics such as drug resistance.The astragalus polysaccharides that the present invention selects mainly has the poultry leukocyte inducement interferon ability of suffering from that improves, Fructus Ligustri Lucidi extract, Fructus Psoraleae extract and Herba Epimedii extract mainly have benefiting action, butafosfan is mainly as the phosphorus supplement agent, and there is the effect that promotes liver function, sodium bicarbonate has certain bactericidal action, vitamin B12 can be used for the neuritis, the non-specific treatment of neuralgia etc., various raw materials there is no obvious alleviation pig immunosuppressant effect while using separately, but through the research of inventor's repetition test, the unexpected discovery: after each raw material is composite according to a certain percentage, between effective ingredient in each raw material, effectively coordinate, synergism is strengthened, the complex that is mainly manifested in gained is added in the pig complete feed, can strengthen the non-specific immunity of pig, can eliminate the stress of pig, alleviate the pig immunosuppressant, improve its resistance against diseases and vitality.
Concrete embodiment
Following examples are intended to further illustrate the present invention, rather than restriction the present invention.
Embodiment 1
One, morbidity basic condition
On May 11st, 2013, the piglet of child care more than the 210 phase secondary disease of the about 21Kg of the body weight of Huaihua City Zhi Jiang county, Hunan Province self-employed pig raiser family left and right, and show obvious hypoimmunity; Acute death is arranged, existing chronic death or the poor growth of becoming thin of later stage multilist in first 4 days.
Two, basic clinical symptoms
40.5 ℃ of left and right of pig body temperature, spirit is depressed, disorderly thick by hair; Rapid breathing, part shows as more obvious ventral breathing; Indivedual pig have sharp ears, afterbody present purple red color spot; Along with the prolongation of time, indivedual pigs are waved on foot, and most of affected pig is become thin gradually.
Three, main pathological anatomical change
Cut open inspection observation main discovery inguinal lymph nodes and mesenteric adenophyma large; Be full of white foam in trachea and bronchus, the part lobe of the lung is meat brown pathological changes (carnification), indivedual pig lung atrophys; Spleen swelling, other organ is without solid lesion.
Four, diagnostic result
Changing tentative diagnosis according to epidemiology, clinical symptoms and pathological anatomy is porcine mycoplasmal secondary circovirus disease, is typical pig immunosuppressive disease.
Five, treatment situation
The conventional therapy scheme of one group of 100 employing of ill pig " tilmicosin+astragalus polysaccharides " spice, after treating 10 days, only have the sub-fraction pig to take a turn for the better, but feed intake is still recovered normally fully; Most of affected pig is not clearly better, and even the part pig state of an illness becomes even more serious, death occurs, does not have dead pig late growing stage speed slow, has become cad pig.
Another organizes 100 use products of the present invention of ill pig, and (wherein astragalus polysaccharides is 0.2 kilogram, 0.5 kilogram of Herba Epimedii extract, 0.5 kilogram of Fructus Ligustri Lucidi extract, 1 kilogram of Fructus Psoraleae extract, 3 kilograms of sodium bicarbonate, 0.01 kilogram of butafosfan, vitamin B12 0.0105 gram is joined 1 ton of complete feed, is treated, pig rehabilitation after 7 days more than 78%, other minority pig returns to one's perfect health about 15 days, there is no other ANOMALOUS VARIATIONS in later stage, and curative effect is significantly better than the conventional therapy group.
Embodiment 2
One, morbidity basic condition
On June 23rd, 2013 starts, 200 many births big porker phase secondary diseases of the about 78Kg of the body weight of Hunan Province Huaihua region self-employed pig raiser family left and right, the obvious dermatitis nephrotic syndrome of main manifestations.
Two, basic clinical symptoms
Pig body temperature, spirit and searching for food is all acted normally, and obviously shows as on skin clinically the red holder that Semen Glycines or Semen Viciae fabae size occur, and more and more, and red sticking together starts to peripheral blackening, then decrustation from central authorities after occurring 3 days.
Three, main pathological anatomical change
Cuing open inspection, to observe major lesions be the typical nephritis pathological changes such as kidney lark, swelling, matter are crisp.Other organ is without solid lesion.
Four, diagnostic result
According to epidemiology, clinical symptoms, pathological anatomy variation diagnostic, it is the dermatitis nephrotic syndrome that Infection of Porcine circovirus causes.
Five, treatment situation
Half ill pig adopts the conventional therapy scheme of antipyretic and antitoxic powder and astragalus polysaccharides spice, after treating 10 days, and the pig rehabilitation less than 70%; Continual cure also has the minority pig to cure in 7 days afterwards.
Second half ill pig is used product of the present invention, and (wherein astragalus polysaccharides is 0.3 kilogram, 1 kilogram of Herba Epimedii extract, 1 kilogram of Fructus Ligustri Lucidi extract, 1 kilogram of Fructus Psoraleae extract, 3 kilograms of sodium bicarbonate, 0.01 kilogram of butafosfan, vitamin B12 0.015 gram is joined 1 ton of complete feed, treated, after 10 days, the pig rehabilitation more than 85%.The sick pig of other parts is in continual cure basic rehabilitation in the time of 7 days, and curative effect is significantly better than the conventional therapy group.
Claims (10)
1. alleviate pig immunosuppressant complex for one kind, it is characterized in that, comprise following mass component:
2. complex as claimed in claim 1, is characterized in that, described complex comprises mcg vitamin B12.
3. complex as claimed in claim 1, is characterized in that, the stem and leaf that described Herba Epimedii extract is Herba Epimedii and/or the extract of root, wherein, the quality percentage composition of icariine >=98%.
4. complex as claimed in claim 1, it is characterized in that, the extract that described Fructus Ligustri Lucidi extract is Oleaceae Ligustrum plant Fructus Ligustri Lucidi mature fruit, wherein, the mass content of specnuezhenside is not less than 0.40%, and oleanolic acid and ursolic acid gross mass content are not less than 1%.
5. complex as claimed in claim 1, is characterized in that, described astragalus polysaccharides purity is not less than 90wt%.
6. complex as claimed in claim 1, is characterized in that, the extract of the dry mature fruit that described Fructus Psoraleae extract is legumes psoraleae, and wherein, the gross mass content of psoralen and isopsorapen is not less than 50%.
7. the application as the described complex of claim 1～6 any one, is characterized in that, is applied to alleviate the immunosuppressant of pig using described complex as pig feed additive.
8. application as claimed in claim 7, is characterized in that, described complex is added in the pig complete feed.
9. application as claimed in claim 8, is characterized in that, the addition of described complex in the pig complete feed is 0.4～0.7wt%.
10. application as claimed in claim 8, it is characterized in that, the addition of described complex in the pig complete feed is: astragalus polysaccharides 0.2～0.3 kg/ton, Herba Epimedii extract 0.5～1 kg/ton, Fructus Ligustri Lucidi extract 0.5～1 kg/ton, Fructus Psoraleae extract 1～2 kg/ton, sodium bicarbonate 2～5 kg/ton, butafosfan 0.01～0.02 kg/ton, vitamin B12 0.010～0.025 gram/ton.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310421620.8A CN103479735B (en) | 2013-09-16 | 2013-09-16 | Compound relieving immunosuppression of pigs and application thereof |
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| CN201310421620.8A CN103479735B (en) | 2013-09-16 | 2013-09-16 | Compound relieving immunosuppression of pigs and application thereof |
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| CN103479735A true CN103479735A (en) | 2014-01-01 |
| CN103479735B CN103479735B (en) | 2015-03-11 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104872443A (en) * | 2015-06-10 | 2015-09-02 | 青岛大信饲料有限公司 | Feed capable of helping cad pig to relieve cad |
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2013
- 2013-09-16 CN CN201310421620.8A patent/CN103479735B/en active Active
Non-Patent Citations (2)
| Title |
|---|
| 任敏等: "黄芪多糖(APS)对断奶仔猪免疫功能的影响", 《郑州牧业工程高等专科学校学报》 * |
| 胡元亮: "中药增强免疫剂最新研究成果发布", 《北方牧业》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104872443A (en) * | 2015-06-10 | 2015-09-02 | 青岛大信饲料有限公司 | Feed capable of helping cad pig to relieve cad |
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| CN103479735B (en) | 2015-03-11 |
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Effective date of registration: 20201216 Address after: 410125 Mapoling, Furong district, Changsha City, Hunan Province Patentee after: CHANGSHA LVYE BIOTECHNOLOGY Co.,Ltd. Address before: 410128, No. 1, Nongda Road, Furong district, Hunan, Changsha Patentee before: Hunan Agricultural University |
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