CN103271966B - Composition for controlling porcine respiratory disease complex and application thereof - Google Patents
Composition for controlling porcine respiratory disease complex and application thereof Download PDFInfo
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- CN103271966B CN103271966B CN201310225145.7A CN201310225145A CN103271966B CN 103271966 B CN103271966 B CN 103271966B CN 201310225145 A CN201310225145 A CN 201310225145A CN 103271966 B CN103271966 B CN 103271966B
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Abstract
The invention discloses a composition for controlling porcine respiratory disease complex and an application thereof. The composition comprises the following components: an echinacea purpurea herb extract product, nano-zinc oxide, Mycobacterium phlei, farrerol, deoxyglucose and astragalus polysaccharide. The composition is used as a feed additive to be applied for controlling porcine respiratory disease complex. By the adoption of the composition provided by the invention, the vast majority of disease causes which trigger porcine respiratory disease complex can be effectively inhibited and killed, various clinical symptoms can be controlled, course of the disease is shortened, death and culling rate is minimized, and growth speed of pigs is raised.
Description
Technical field
The present invention relates to a kind of composition and application thereof of controlling porcine respiratory syndrome, belong to field of veterinary.
Background technology
The main pathogen that causes " porcine respiratory syndrome " disease comprises the pathogens such as virus (pig breeding and breathing syndrome virus, Pseudorabies virus, pig circular ring virus, PRCV, influenza virus etc.), bacterium (Pasteurella, streptococcus, Actinobacillus and haemophilus parasuis etc.), mycoplasma, and airborne toxic and harmful (ammonia, hydrogen sulfide and scatol etc.) and mixed infection and the scabies secondary infection that stress factor causes such as feeding and management is bad.
The main method of existing control " porcine respiratory syndrome " be use antibiotics Western medicine (as Florfenicol, Tilmicosin, Tiamulin, tylosin etc.) and have reduce phlegm, Chinese herbal medicine and the preparation (as balloonflower root, Radix Glycyrrhizae, the root bark of white mulberry, Momordica grosvenori, loguat leaf, tarragon etc.) thereof of antitussive and antiasthmatic effect.And antibiotics Western medicine can only be treated responsive microbial porcine respiratory disease, and invalid to virus and nonpathogenic bacteria; Even the breathing problem that treatment sensitive bacteria causes is also usually cured the symptoms, not the disease, outbreak very easily repeatedly, meanwhile, the long-time use of antibiotic heavy dose easily causes immunity of organism to suppress, and easily produces drug resistance simultaneously and causes medicament residue.Although Chinese herbal medicine can be alleviated clinical symptoms (reduce phlegm, antibechic, relieving asthma) to a certain extent, and pathogen is had to certain inhibitory or killing effect, uncertain therapeutic efficacy is real and very unstable.
Summary of the invention
The present invention is directed to the medicine of controlling porcine respiratory syndrome in prior art exist cure the symptoms, not the disease, easily outbreak and the unsettled defect of curative effect repeatedly, but object is to provide a kind of and can effectively kills most cause of diseases of initiation " porcine respiratory syndrome " and control various clinical symptoms, shorten the course of disease, reduce death rate, improve the composition of the control porcine respiratory syndrome of growth speed of pigs.
Another object of the present invention is to provide a kind of application of above-mentioned composition, be added on the control that is applied to porcine respiratory syndrome in feed, but can effectively kill most cause of diseases of initiation " porcine respiratory syndrome " and control various clinical symptoms, shorten the course of disease, reduce death rate, improve growth speed of pigs.
The invention provides a kind of composition of controlling porcine respiratory syndrome, this additive comprises following mass component:
0.05～0.1 part of Echinacea Purpurea Herb P.E;
0.5～1 part of nano zine oxide;
1～3 part of Mycobacterium graminis;
0.15～0.3 part of farrerol;
0.1～0.2 part of deoxyglucose;
0.2～0.3 part of astragalus polyose.
In described Echinacea Purpurea Herb P.E, the content of polyphenol compound is not less than 4wt% in dry product.
Described Echinacea Purpurea Herb P.E is the cauline leaf of Echinacea or the extract of root; Can buy in Sichuan Tong Tai plant Chemical Co., Ltd. the companies such as bio tech ltd, source, the world, Shaanxi or Xi'an Fei Da Bioisystech Co., Ltd.
Described farrerol purity is not less than 95wt%; Described farrerol be Rhododendron dauricum and other Rhododendron in Lushan Botanical Gardens in extract; Can buy the companies such as Yuan Ye bio tech ltd, Shanghai, Shanghai Fu Sheng Industrial Co., Ltd. or upper ingression Ke Industrial Co., Ltd..
Described astragalus polyose purity is not less than 90wt%; Described astragalus polyose is the root extract of astragalus mongolicus or Astragalus membranacus, mainly comprises the water-soluble heteropolysaccharides such as sugar such as hexuronic acid, glucose, fructose, rhamnose, arabinose, galacturonic acid and glucuronic acid; Can buy in Jiangxi Kang Shengtang pharmaceutcal corporation, Ltd, Sichuan Tong Tai plant Chemical Co., Ltd. bio tech ltd, source, the world, Shaanxi, Tianjin Hua Long Medicines and Health Product Co., Ltd or Zhengzhou Yi Yin plant material Co., Ltd.
Described nano granular of zinc oxide size is 1～100nm.
The preparation method of composition of the present invention is after Echinacea Purpurea Herb P.E and deoxyglucose being stirred by mass parts ratio of component, in gained mixture, add successively farrerol, astragalus polyose, nano zine oxide, Mycobacterium graminis, after often adding a component, stir, must control the composition of porcine respiratory syndrome.
The present invention also provides a kind of application of composition as above, is applied to the control of porcine respiratory syndrome using described composition as feed addictive.
Described composition is added in pig complete feed.
The addition of described composition in pig complete feed is 0.2～0.5wt%.
Described composition is added in pig complete feed; Wherein, Echinacea Purpurea Herb P.E 0.05～0.1 kg/ton complete feed, nano zine oxide 0.5～1 kg/ton complete feed, deoxyglucose 0.1～0.2 kg/ton complete feed, Mycobacterium graminis 1～3 kg/ton complete feed, astragalus polyose 0.2～0.3 kg/ton complete feed, farrerol 0.15～0.3 kg/ton complete feed.
In above-mentioned application, the control of porcine respiratory syndrome allows pig connect the edible complete feed that has added described composition 7～10 days.
Beneficial effect of the present invention: the present invention passes through repetition test, organic Echinacea Purpurea Herb P.E of the effect of antiviral by having, antimycotic, the antitumor and desinsection of discovery, anti-inflammatory, in conjunction with thering is antibacterial bacteriostatic, the inorganic nano zinc oxide of a series of special performances such as the anti-enzyme of taste of dispelling, play comprehensively antiviral, antibacterial effect; On this basis further combined with the deoxyglucose that can block germ energetic supersession, inhibition viral growth and breeding, and improve the astragalus polyose of trouble poultry leucocyte inducement interferon ability and the Mycobacterium graminis that adjusting cell immune system produces immunologic function, enhancing body immunity, mainly can strengthen from suppressing virus and trouble poultry immunity aspect the ability of trouble poultry opposing germ; Above-mentioned each composition effectively coordinates, and synergy, is re-dubbed composition porcine respiratory syndrome to fine drug effect; In addition, also add farrerol, made the sputum of affected pig thinning, be easy to expectoration, and amount of expectoration is reduced gradually, to suffering from respiratory complication, played a good auxiliary effect effect; Simultaneously BA, the absorptivity of Nano-Zinc are high, also improve breeding performonce fo animals when playing the effect of antibacterial bacteriostatic; Said composition is added in pig feed as additive, but can effectively kills most cause of diseases of initiation " porcine respiratory syndrome " and control various clinical symptoms, shorten the course of disease, reduce death rate, improve the speed of growth; Product of the present invention is used Chinese herbal medicine effective ingredients, inorganic matter and the beneficial microbe bacterium with unique function to form through science compatibility first, has environmental protection, curative effect really and is difficult for producing drug resistance and is difficult for the features such as recurrence.
Concrete embodiment
Following examples are intended to further illustrate the present invention, rather than restriction the present invention.
Embodiment 1
After 0.1 kilogram of Echinacea Purpurea Herb P.E is stirred with 0.2 kilogram of deoxyglucose, in gained mixture, add successively 0.15 kilogram of farrerol, 0.2 kilogram of astragalus polyose, 0.5 kilogram of nano zine oxide, 2 kilograms of Mycobacterium graminis, after often adding a component, stir, finally obtain composition.
Embodiment 2
After 0.1 kilogram of Echinacea Purpurea Herb P.E is stirred with 0.2 kilogram of deoxyglucose, in gained mixture, add successively 0.3 kilogram of farrerol, 0.3 kilogram of astragalus polyose, 1.0 kilograms of nano zine oxides, 3 kilograms of Mycobacterium graminis, after often adding a component, stir, finally obtain composition.
Embodiment 3
After 0.08 kilogram of Echinacea Purpurea Herb P.E is stirred with 0.15 kilogram of deoxyglucose, in gained mixture, add successively 0.25 kilogram of farrerol, 0.3 kilogram of astragalus polyose, 0.5 kilogram of nano zine oxide, 2 kilograms of Mycobacterium graminis, after often adding a component, stir, finally obtain composition.
Embodiment 4
One, morbidity basic condition
On February 21st, 2013 starts, the piglet of child care more than the 260 phase secondary disease of the about 25Kg of the body weight left and right of Hunan Province Yiyang City self-employed pig raiser family, and show obvious respiratory symptom; Within first 5 days, there is acute death, general dead 30 bulls.
Two, basic clinical symptoms
Pig hyperthermia to 40～41.5 ℃, spirit is depressed, and it is rubescent that skin has, and is short of breath, and part shows as more obvious abdominal respiration; Indivedual pig have sharp ears, afterbody present purple red color spot; Along with the prolongation of time, indivedual pigs are waved on foot, and part affected pig is become thin gradually.
Three, main pathological anatomical change
Cut open main discovery of inspection observation and be full of white foam in trachea and bronchus, tube wall is congested; Pulmonary emphysema, the part lobe of the lung is meat brown pathology (carnification), indivedual pig lung atrophys; Inguinal lymph nodes and hilar lymph node enlargement; Some spleen swelling, other organ is without solid lesion.
Four, diagnostic result
According to epidemiology, clinical symptoms and pathological anatomy, changing tentative diagnosis is that pig infects mycoplasma initiation acute infection pleuropneumonia, is one of typical porcine respiratory syndrome.
Five, treatment situation
The conventional therapy scheme of one group of 100 employing of ill pig " Tilmicosin+Florfenicol " antibiotic spice, treat after 7 days, the pig rehabilitation of 87% left and right, although but also have sub-fraction pig to show to have had an optimistic view of, but feed intake cannot be recovered normally in a short time completely, indivedual pig late growing stage speed is slow, has even become cad pig, and feedstuff-meat ratio also increases greatly, easily recurrence.
Another organizes 100 composition products that use the embodiment of the present invention 1 preparation of ill pig, by 0.3wt% spice, add in pig complete feed, treat, pig rehabilitation after 5 days more than 95%, other minority pig returned to one's perfect health in the time of 7～8 days, other ANOMALOUS VARIATIONS that there is no the later stage, curative effect is significantly better than antibiotic therapy.
Embodiment 5
One, morbidity basic condition
On April 15th, 2013 starts, 200 many births big porker phase secondary diseases of the about 62Kg of the body weight left and right of Huaihua region, Hunan Province self-employed pig raiser family, the obvious respiratory symptom of main manifestations.
Two, basic clinical symptoms
Pig hyperthermia to 40.5～42 ℃, spirit is highly depressed, does not like motion, waves on foot or astasia, and indivedual pig performance nervous symptoms, are short of breath, and obviously show abdominal respiration; White or celadon purulent secretion are flowed out in nostril, and conjunctival congestion is rubescent, eyelid and bulbar conjunctiva swelling, and most of ill pig rubefaction, indivedual pig have sharp ears, afterbody and body partly present purple red color spot., the rate of dying is higher.
Three, main pathological anatomical change
Cut open main discovery of inspection observation and be full of white foam or red blood in trachea and bronchus, tube wall is congested; Interstitial lung broadening, wind-puff, most of lobe of the lung is carnification, indivedual pig lung atrophys; The congested swelling of inguinal lymph nodes, hilar lymph node and lymph nodes of body as a whole, some severe haemorrhages; Liver, spleen swelling; Kidney lark, swelling, matter is crisp; Other organ is without solid lesion.
Four, diagnostic result
According to epidemiology, clinical symptoms, pathological anatomy variation and laboratory diagnosis, being the mixed infection of pig blue-ear disease, haemophilus parasuis and contagious pleuropneumonia, is one of typical swine disease poison and bacillary mixed infection type respiratory complication.
Five, treatment situation
Half ill pig adopts the conventional therapy scheme of " Tilmicosin+Florfenicol+astragalus polyose+vitamin C etc. " spice, treats after 10 days the pig rehabilitation less than 64%, dead 14; Continual cure also has tens pigs cannot cure and abandon treatment for 7 days afterwards, takes method for innocent treatment to process.
Second half ill pig is used the embodiment of the present invention 2 products to add in pig complete feed by 0.49wt%, treats after 10 days more than 73% pig rehabilitation.Other most of sick pig, in continual cure basic rehabilitation in the time of 10 days, amounts to dead 9.Curative effect is significantly better than conventional therapy group.
Claims (7)
1. a composition of controlling porcine respiratory syndrome, is characterized in that, comprises following mass component:
0.05～0.1 part of Echinacea Purpurea Herb P.E;
0.5～1 part of nano zine oxide;
1～3 part of Mycobacterium graminis;
0.15～0.3 part of farrerol;
0.1～0.2 part of deoxyglucose;
0.2～0.3 part of astragalus polyose;
In described Echinacea Purpurea Herb P.E, the content of polyphenol compound is not less than 4wt% in dry product.
2. composition as claimed in claim 1, is characterized in that, the cauline leaf that described Echinacea Purpurea Herb P.E is Echinacea or the extract of root.
3. composition as claimed in claim 1, is characterized in that, described farrerol purity is not less than 95wt%.
4. composition as claimed in claim 1, is characterized in that, described astragalus polyose purity is not less than 90wt%.
5. an application for the composition as described in claim 1～4 any one, is characterized in that, described composition is applied to the feed addictive that porcine respiratory syndrome is controlled in preparation.
6. application as claimed in claim 5, is characterized in that, the addition of described composition in pig complete feed is 0.2～0.5wt%.
7. application as claimed in claim 5, is characterized in that, described composition is added in pig complete feed; Wherein, Echinacea Purpurea Herb P.E 0.05～0.1 kg/ton complete feed, nano zine oxide 0.5～1 kg/ton complete feed, deoxyglucose 0.1～0.2 kg/ton complete feed, Mycobacterium graminis 1～3 kg/ton complete feed, astragalus polyose 0.2～0.3 kg/ton complete feed, farrerol 0.15～0.3 kg/ton complete feed.
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Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103549150B (en) * | 2013-11-05 | 2015-03-25 | 安徽科技学院 | Compound feed additive for green broiler chickens |
| CN104187112B (en) * | 2014-08-27 | 2016-04-06 | 南昌傲农生物科技有限公司 | A kind of premixed feed by sow feeding enhancing pigling immunity and preparation method thereof |
| CN105168292B (en) * | 2015-09-30 | 2019-03-08 | 成都乾坤动物药业有限公司 | A kind of relieving cough and asthma veterinary medical composition and preparation method thereof |
| CN105106287A (en) * | 2015-09-30 | 2015-12-02 | 成都乾坤动物药业有限公司 | Animal medicinal composition for relieving cough and removing phlegm and preparation method of animal medicinal composition |
| CN106721319B (en) * | 2017-01-19 | 2020-04-10 | 湖南农业大学 | Three-section type composition for preventing and controlling porcine respiratory diseases and application thereof |
| CN107348196A (en) * | 2017-07-31 | 2017-11-17 | 贵港正邦农牧科技有限公司 | A kind of feedstuff for live pigs and preparation method thereof |
| CN111109304B (en) * | 2019-12-30 | 2021-04-02 | 广东省农业科学院动物科学研究所 | Disinfectant composition for improving pig immunity and antiviral ability and application method thereof |
| CN113371753A (en) * | 2021-06-07 | 2021-09-10 | 江苏农林职业技术学院 | Nano zinc and green synthesis method and application thereof |
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| CN100363022C (en) * | 2004-06-04 | 2008-01-23 | 成都地奥制药集团有限公司 | Pharmaceutical composition with immunoregulation function and method for preparing the same |
| CN102716164B (en) * | 2012-06-28 | 2014-11-12 | 齐鲁动物保健品有限公司 | Echinacea extract and preparation method of echinacea extract |
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Effective date of registration: 20201225 Address after: 410125 Mapoling, Furong district, Changsha City, Hunan Province Patentee after: CHANGSHA LVYE BIOTECHNOLOGY Co.,Ltd. Address before: 410128, No. 1, Nongda Road, Furong district, Hunan, Changsha Patentee before: Hunan Agricultural University Patentee before: CHANGSHA LVYE BIOTECHNOLOGY Co.,Ltd. |