CN103476927A - 发酵单胞菌中的泛酸生物合成 - Google Patents

发酵单胞菌中的泛酸生物合成 Download PDF

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Publication number
CN103476927A
CN103476927A CN2012800159591A CN201280015959A CN103476927A CN 103476927 A CN103476927 A CN 103476927A CN 2012800159591 A CN2012800159591 A CN 2012800159591A CN 201280015959 A CN201280015959 A CN 201280015959A CN 103476927 A CN103476927 A CN 103476927A
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polypeptide
aspartate
bacterial strain
decarboxylase
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Chinese (zh)
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陶峦
J-F.汤布
P.V.维坦恩
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EIDP Inc
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EI Du Pont de Nemours and Co
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/02—Amides, e.g. chloramphenicol or polyamides; Imides or polyimides; Urethanes, i.e. compounds comprising N-C=O structural element or polyurethanes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
    • C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
    • C12P7/06—Ethanol, i.e. non-beverage
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
    • C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
    • C12P7/06—Ethanol, i.e. non-beverage
    • C12P7/065—Ethanol, i.e. non-beverage with microorganisms other than yeasts
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
    • C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
    • C12Y101/01169—2-Dehydropantoate 2-reductase (1.1.1.169), i.e. ketopantoate-reductase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y401/00—Carbon-carbon lyases (4.1)
    • C12Y401/01—Carboxy-lyases (4.1.1)
    • C12Y401/01011—Aspartate 1-decarboxylase (4.1.1.11)
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
    • Y02E50/00—Technologies for the production of fuel of non-fossil origin
    • Y02E50/10—Biofuels, e.g. bio-diesel

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
CN2012800159591A 2011-04-07 2012-04-06 发酵单胞菌中的泛酸生物合成 Pending CN103476927A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161472664P 2011-04-07 2011-04-07
US61/472,664 2011-04-07
PCT/US2012/032558 WO2012145179A1 (en) 2011-04-07 2012-04-06 Pantothenic acid biosynthesis in zymomonas

Publications (1)

Publication Number Publication Date
CN103476927A true CN103476927A (zh) 2013-12-25

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CN2012800159591A Pending CN103476927A (zh) 2011-04-07 2012-04-06 发酵单胞菌中的泛酸生物合成

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US (1) US8765426B2 (enExample)
EP (1) EP2694648A1 (enExample)
JP (1) JP2014511699A (enExample)
CN (1) CN103476927A (enExample)
AU (1) AU2012245871A1 (enExample)
BR (1) BR112013025716A2 (enExample)
CA (1) CA2832559A1 (enExample)
WO (1) WO2012145179A1 (enExample)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111718396A (zh) * 2019-03-21 2020-09-29 中央研究院 合成肽，包含该合成肽的药学组合物，以及其在治疗与栓塞相关的疾病中的用途
CN112195143A (zh) * 2020-09-24 2021-01-08 浙江工业大学 一种用于发酵法生产d-泛酸的菌株及发酵法生产d-泛酸的方法
CN117736959A (zh) * 2024-01-26 2024-03-22 湖北大学 运动发酵单胞菌的工程菌株、制备方法及应用
WO2024114333A1 (en) * 2022-11-28 2024-06-06 Enzymaster (Ningbo) Bio-Engineering Co., Ltd. An enzyme catalyst and method for synthesizing D-pantoic acid

Families Citing this family (8)

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US20130316364A1 (en) * 2012-05-23 2013-11-28 Lanzatech New Zealand Limited Selection Method and Recombinant Microorganisms and uses Therefor
WO2014087184A1 (en) * 2012-12-03 2014-06-12 Metabolic Explorer Neopentyl glycol fermentative production by a recombinant microorganism
US9580758B2 (en) 2013-11-12 2017-02-28 Luc Montagnier System and method for the detection and treatment of infection by a microbial agent associated with HIV infection
CN110835610B (zh) * 2018-08-17 2022-08-26 吉林农业大学 一种适用于降解秸秆的复合菌剂及制备方法
CN109402097A (zh) * 2018-10-23 2019-03-01 江南大学 一种L-天冬氨酸α-脱羧酶的基因工程菌株以及应用
CN110055188A (zh) * 2019-03-07 2019-07-26 南京师范大学 一株产抑菌肽的多粘类芽孢杆菌xw4及其分离筛选和应用
CN111088206A (zh) * 2020-01-07 2020-05-01 江南大学 一种酶法生产d-泛酸的方法
CN116640700B (zh) * 2023-06-24 2024-05-14 西南大学 一株抑制黄曲霉生长和毒素产生的副干酪乳杆菌f50及其应用

Citations (5)

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CN1254758A (zh) * 1998-10-09 2000-05-31 底古萨－胡尔斯股份公司 通过扩增编码酮泛解酸盐还原酶的核苷酸序列制备泛酸的方法
WO2003006664A2 (en) * 2001-07-07 2003-01-23 Degussa Ag Process for the preparation of d-pantothenic acid and/or salts thereof
CN1420931A (zh) * 1999-09-21 2003-05-28 Basf公司 制备泛化合物的方法和微生物
WO2010085731A2 (en) * 2009-01-23 2010-07-29 Microbia, Inc. Production of 1,4 butanediol in a microorganism
CN101970671A (zh) * 2007-10-30 2011-02-09 纳幕尔杜邦公司 在包含浓缩糖和乙酸盐的培养基中具有改进的乙醇产量的发酵单胞菌属

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US5712133A (en) 1994-04-15 1998-01-27 Midwest Research Institute Pentose fermentation by recombinant zymomonas
US5514583A (en) 1994-04-15 1996-05-07 Midwest Research Institute Recombinant zymomonas for pentose fermentation
WO1995028476A1 (en) 1994-04-15 1995-10-26 Midwest Research Institute Recombinant zymomonas for pentose fermentation
US8232081B2 (en) 1999-09-21 2012-07-31 Basf Se Methods and microorganisms for production of panto-compounds
US7223575B2 (en) 2000-05-01 2007-05-29 Midwest Research Institute Zymomonas pentose-sugar fermenting strains and uses thereof
DE60327804D1 (de) 2002-01-18 2009-07-09 Novozymes As Alanin-2,3-aminomutase
WO2006022664A2 (en) 2004-07-30 2006-03-02 Cargill Incorporated Alanine 2, 3 aminomutases
JP5149785B2 (ja) 2005-04-12 2013-02-20 イー・アイ・デュポン・ドウ・ヌムール・アンド・カンパニー エタノールを得るためのバイオマスの処理
US7629156B2 (en) 2006-09-28 2009-12-08 E.I. Du Pont De Nemours And Company Ethanol production in fermentation of mixed sugars containing xylose
US7741119B2 (en) 2006-09-28 2010-06-22 E. I. Du Pont De Nemours And Company Xylitol synthesis mutant of xylose-utilizing zymomonas for ethanol production
US7741084B2 (en) 2006-09-28 2010-06-22 E. I. Du Pont De Nemours And Company Ethanol production using xylitol synthesis mutant of xylose-utilizing zymomonas
ATE506447T1 (de) 2007-10-30 2011-05-15 Du Pont Verfahren zur herstellung von etahnol in einem xylose enthaltenden medium unter verwendung eines rekombinanten zymomonas stammes mit reduzierter hima expression
CA2716585C (en) 2008-03-27 2017-05-09 E.I. Du Pont De Nemours And Company Zymomonas recombinant for substituted glyceraldehyde-3-phosphate dehydrogenase promoter and xylose isomerase gene for improved xylose utilization
ES2627671T3 (es) 2008-03-27 2017-07-31 E. I. Du Pont De Nemours And Company Promotores de Zymomonas de alta expresión
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CN1254758A (zh) * 1998-10-09 2000-05-31 底古萨－胡尔斯股份公司 通过扩增编码酮泛解酸盐还原酶的核苷酸序列制备泛酸的方法
CN1420931A (zh) * 1999-09-21 2003-05-28 Basf公司 制备泛化合物的方法和微生物
WO2003006664A2 (en) * 2001-07-07 2003-01-23 Degussa Ag Process for the preparation of d-pantothenic acid and/or salts thereof
CN101970671A (zh) * 2007-10-30 2011-02-09 纳幕尔杜邦公司 在包含浓缩糖和乙酸盐的培养基中具有改进的乙醇产量的发酵单胞菌属
WO2010085731A2 (en) * 2009-01-23 2010-07-29 Microbia, Inc. Production of 1,4 butanediol in a microorganism

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Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111718396A (zh) * 2019-03-21 2020-09-29 中央研究院 合成肽，包含该合成肽的药学组合物，以及其在治疗与栓塞相关的疾病中的用途
CN112195143A (zh) * 2020-09-24 2021-01-08 浙江工业大学 一种用于发酵法生产d-泛酸的菌株及发酵法生产d-泛酸的方法
WO2024114333A1 (en) * 2022-11-28 2024-06-06 Enzymaster (Ningbo) Bio-Engineering Co., Ltd. An enzyme catalyst and method for synthesizing D-pantoic acid
CN117736959A (zh) * 2024-01-26 2024-03-22 湖北大学 运动发酵单胞菌的工程菌株、制备方法及应用
CN117736959B (zh) * 2024-01-26 2024-05-14 湖北大学 运动发酵单胞菌的工程菌株、制备方法及应用

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Publication number Publication date
US20130078694A1 (en) 2013-03-28
BR112013025716A2 (pt) 2016-12-13
CA2832559A1 (en) 2012-10-26
US8765426B2 (en) 2014-07-01
AU2012245871A1 (en) 2013-08-15
WO2012145179A1 (en) 2012-10-26
EP2694648A1 (en) 2014-02-12
JP2014511699A (ja) 2014-05-19

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