CN103458922B - 诱导对甲型流感病毒的异源亚型免疫反应的重组病毒载体和方法 - Google Patents
诱导对甲型流感病毒的异源亚型免疫反应的重组病毒载体和方法 Download PDFInfo
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- CN103458922B CN103458922B CN201280015880.9A CN201280015880A CN103458922B CN 103458922 B CN103458922 B CN 103458922B CN 201280015880 A CN201280015880 A CN 201280015880A CN 103458922 B CN103458922 B CN 103458922B
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- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
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- C12N2710/00011—Details
- C12N2710/24011—Poxviridae
- C12N2710/24111—Orthopoxvirus, e.g. vaccinia virus, variola
- C12N2710/24122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
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- C12N2710/24011—Poxviridae
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- C12N2710/00011—Details
- C12N2710/24011—Poxviridae
- C12N2710/24111—Orthopoxvirus, e.g. vaccinia virus, variola
- C12N2710/24134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2710/00011—Details
- C12N2710/24011—Poxviridae
- C12N2710/24111—Orthopoxvirus, e.g. vaccinia virus, variola
- C12N2710/24141—Use of virus, viral particle or viral elements as a vector
- C12N2710/24143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
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- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
- C12N2760/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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- Bioinformatics & Cheminformatics (AREA)
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- Medicinal Chemistry (AREA)
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- General Engineering & Computer Science (AREA)
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- Chemical Kinetics & Catalysis (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161438024P | 2011-01-31 | 2011-01-31 | |
| US61/438,024 | 2011-01-31 | ||
| PCT/US2012/023085 WO2012106231A2 (en) | 2011-01-31 | 2012-01-30 | Recombinant viral vectors and methods for inducing a heterosubtypic immune response to influenza a viruses |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103458922A CN103458922A (zh) | 2013-12-18 |
| CN103458922B true CN103458922B (zh) | 2017-10-03 |
Family
ID=45561167
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201280015880.9A Active CN103458922B (zh) | 2011-01-31 | 2012-01-30 | 诱导对甲型流感病毒的异源亚型免疫反应的重组病毒载体和方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US9463237B2 (enExample) |
| EP (1) | EP2670430B1 (enExample) |
| JP (2) | JP6169494B2 (enExample) |
| CN (1) | CN103458922B (enExample) |
| AU (2) | AU2012212463B2 (enExample) |
| WO (1) | WO2012106231A2 (enExample) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2670430B1 (en) * | 2011-01-31 | 2015-04-01 | Baxter International Inc | Recombinant viral vectors and methods for inducing a heterosubtypic immune response to influenza a viruses |
| US10434166B2 (en) * | 2013-03-15 | 2019-10-08 | University Of Maryland, College Park | Methods and compositions for in vivo immune stimulation and antigen production |
| US10286062B2 (en) | 2013-07-09 | 2019-05-14 | Texas Tech University System | Universal influenza vaccine |
| CA3003103A1 (en) * | 2015-10-22 | 2017-04-27 | Modernatx, Inc. | Broad spectrum influenza virus vaccine |
| PL3402802T3 (pl) * | 2016-01-08 | 2023-06-05 | Geovax, Inc. | Kompozycje i sposoby generowania odpowiedzi immunologicznej względem antygenu powiązanego z guzem nowotworowym |
| US10370416B2 (en) * | 2016-03-01 | 2019-08-06 | Texas Tech University System | Dual purpose universal influenza vaccine confers protective immunity against anthrax |
| KR102731582B1 (ko) | 2016-06-03 | 2024-11-15 | 사노피 파스퇴르 인코포레이티드 | 조작된 인플루엔자 헤마글루티닌 폴리펩티드의 변형 |
| CN107841513B (zh) * | 2016-09-18 | 2023-04-14 | 中国科学院上海巴斯德研究所 | 基于M2e表位的广谱型流感疫苗 |
| US10925958B2 (en) | 2016-11-11 | 2021-02-23 | Modernatx, Inc. | Influenza vaccine |
| US11311612B2 (en) | 2017-09-19 | 2022-04-26 | Geovax, Inc. | Compositions and methods for generating an immune response to treat or prevent malaria |
| JP7382634B2 (ja) * | 2017-12-21 | 2023-11-17 | 株式会社グリーンバイオメッド | 交差免疫抗原ワクチン及びその調製方法 |
| CN109096376A (zh) * | 2018-09-20 | 2018-12-28 | 扬州大学 | 流感病毒ha多肽、klh偶联多肽及多克隆抗体的制备方法 |
| CN113004422B (zh) * | 2021-03-04 | 2023-01-20 | 辽宁成大生物股份有限公司 | 一种融合蛋白、含其的疫苗及其应用 |
| WO2023019274A1 (en) * | 2021-08-13 | 2023-02-16 | Purdue Research Foundation | Methods and compositions for vaccination against heterosubtypic influenza viruses using an adenoviral vector leading to enhanced t cell response through autophagy |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008118487A2 (en) * | 2007-03-26 | 2008-10-02 | University Of Massachusetts Medical School | Compositions and methods for incresing immunogenicity of glycoprotein vaccines |
| WO2010117786A1 (en) * | 2009-03-30 | 2010-10-14 | Mount Sinai School Of Medicine Of New York University | Influenza virus vaccines and uses thereof |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7045313B1 (en) | 1982-11-30 | 2006-05-16 | The United States Of America As Represented By The Department Of Health And Human Services | Recombinant vaccinia virus containing a chimeric gene having foreign DNA flanked by vaccinia regulatory DNA |
| AT393277B (de) | 1990-01-04 | 1991-09-25 | Immuno Ag | Verfahren zur herstellung von fruehsommer- meningoenzephalitis-virus (fsme-virus)-antigen |
| MX2008009929A (es) * | 2006-02-02 | 2008-10-01 | Globeimmune Inc | Vacuna a base de levadura para inducir una respuesta inmune. |
| EP1820511A1 (en) * | 2006-02-20 | 2007-08-22 | Prolmmune Limited | MHC binding peptides and their uses |
| CA2673994A1 (en) * | 2006-12-29 | 2008-07-24 | Institut Pasteur Of Shanghai | Lentivirus pseudotyped with influenza hemagglutinin and methods of use |
| US20110177122A1 (en) * | 2008-09-26 | 2011-07-21 | The United States Of America, As Represented By The Secretary, Dept. Of Health & Human Services | Dna prime/activated vaccine boost immunization to influenza virus |
| US7998488B2 (en) | 2008-11-14 | 2011-08-16 | Baxter International Inc. | Vaccine formulations and uses thereof |
| CA2762044A1 (en) | 2009-05-18 | 2010-11-25 | Panacea Biotec Ltd | Universal influenza vaccine based on recombinant modified vaccinia ankara virus (mva) |
| EP2670430B1 (en) | 2011-01-31 | 2015-04-01 | Baxter International Inc | Recombinant viral vectors and methods for inducing a heterosubtypic immune response to influenza a viruses |
-
2012
- 2012-01-30 EP EP12702162.4A patent/EP2670430B1/en active Active
- 2012-01-30 AU AU2012212463A patent/AU2012212463B2/en active Active
- 2012-01-30 JP JP2013552568A patent/JP6169494B2/ja active Active
- 2012-01-30 WO PCT/US2012/023085 patent/WO2012106231A2/en not_active Ceased
- 2012-01-30 CN CN201280015880.9A patent/CN103458922B/zh active Active
- 2012-01-30 US US13/982,524 patent/US9463237B2/en active Active
-
2016
- 2016-09-30 AU AU2016235002A patent/AU2016235002B2/en active Active
- 2016-10-07 US US15/289,106 patent/US10329583B2/en active Active
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2017
- 2017-06-28 JP JP2017126499A patent/JP6461244B2/ja active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008118487A2 (en) * | 2007-03-26 | 2008-10-02 | University Of Massachusetts Medical School | Compositions and methods for incresing immunogenicity of glycoprotein vaccines |
| WO2010117786A1 (en) * | 2009-03-30 | 2010-10-14 | Mount Sinai School Of Medicine Of New York University | Influenza virus vaccines and uses thereof |
Non-Patent Citations (6)
| Title |
|---|
| A Pandemic influenza H1N1 live vaccine based on modified vaccinia ankara is highly immunogenic and protects mice in active and passive immunizations;ANNETT HESSEL ET AL;《PLOS ONE》;20100101;第5卷(第8期);E12217 * |
| A universal influenza A vaccine based on adenovirus expressing matrix-2 ectodomain and nucleoprotein protects mice from lethal challenge;ZHOU DONGMING et al;《MOLECULAR THERAPY:THE JOURNAL OF THE AMERICAN SOCIETY OF GENE THERAPY》;20101231;第18卷(第12期);2182-2189 * |
| Comparative efficacy of hemagglutinin,nucleoprotein,and matrix 2 protein gene-based vaccination against H5N1 influenza in mouse and ferret;SRINIVAS S.RAO ET AL;《PLOS ONE》;20100101;第5卷(第3期);E9812 * |
| Heterosubtypic protection conferred by combined vaccination with M2e peptide and split influenza vaccine;WU F ET AL;《VACCINE》;20091009;第27卷(第43期);6095-6101 * |
| Influenza virus vaccine based on the conserved hemagglutinin stalk domain;STEEL JOHN ET AL;《MBIO》;20100430;第1卷(第1期) * |
| M2e-based universal influenza a vaccine;FIERS WALTER ET AL;《Vaccine》;20091023;第27卷(第45期);6280-6283 * |
Also Published As
| Publication number | Publication date |
|---|---|
| JP6169494B2 (ja) | 2017-07-26 |
| WO2012106231A3 (en) | 2012-09-20 |
| WO2012106231A2 (en) | 2012-08-09 |
| AU2016235002B2 (en) | 2018-08-09 |
| EP2670430B1 (en) | 2015-04-01 |
| US10329583B2 (en) | 2019-06-25 |
| US9463237B2 (en) | 2016-10-11 |
| EP2670430A2 (en) | 2013-12-11 |
| JP2017221195A (ja) | 2017-12-21 |
| US20170121735A1 (en) | 2017-05-04 |
| JP6461244B2 (ja) | 2019-01-30 |
| AU2012212463B2 (en) | 2016-07-07 |
| CN103458922A (zh) | 2013-12-18 |
| US20140050759A1 (en) | 2014-02-20 |
| JP2014506785A (ja) | 2014-03-20 |
| AU2012212463A1 (en) | 2013-05-02 |
| AU2016235002A1 (en) | 2016-10-27 |
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Effective date of registration: 20160923 Address after: Swiss Aupu Applicant after: Baxter Co. Address before: Illinois State Applicant before: Baxter International Inc. Applicant before: BAXTER HEALTHCARE S.A. Effective date of registration: 20160923 Address after: American Florida Applicant after: nanomedicine Address before: Swiss Aupu Applicant before: Baxter Co. |
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