AU2012212463B2 - Recombinant viral vectors and methods for inducing a heterosubtypic immune response to influenza A viruses - Google Patents

Recombinant viral vectors and methods for inducing a heterosubtypic immune response to influenza A viruses Download PDF

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AU2012212463B2
AU2012212463B2 AU2012212463A AU2012212463A AU2012212463B2 AU 2012212463 B2 AU2012212463 B2 AU 2012212463B2 AU 2012212463 A AU2012212463 A AU 2012212463A AU 2012212463 A AU2012212463 A AU 2012212463A AU 2012212463 B2 AU2012212463 B2 AU 2012212463B2
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mva
seq
region
set out
gene cassette
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AU2012212463A1 (en
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P. Noel Barrett
Hartmut Ehrlich
Falko-Gunter Falkner
Annett Hessel
Thomas R. Kreil
Birgit Schafer
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Ology Bioservices Inc
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Nanotherapeutics Inc
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    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86Viral vectors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/12Viral antigens
    • A61K39/145Orthomyxoviridae, e.g. influenza virus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K39/275Poxviridae, e.g. avipoxvirus
    • A61K39/285Vaccinia virus or variola virus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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    • C12N2710/24011Poxviridae
    • C12N2710/24111Orthopoxvirus, e.g. vaccinia virus, variola
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    • C12N2710/24011Poxviridae
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    • C12N2710/24011Poxviridae
    • C12N2710/24111Orthopoxvirus, e.g. vaccinia virus, variola
    • C12N2710/24134Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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    • C12N2710/00011Details
    • C12N2710/24011Poxviridae
    • C12N2710/24111Orthopoxvirus, e.g. vaccinia virus, variola
    • C12N2710/24141Use of virus, viral particle or viral elements as a vector
    • C12N2710/24143Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
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    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2760/00011Details
    • C12N2760/16011Orthomyxoviridae
    • C12N2760/16111Influenzavirus A, i.e. influenza A virus
    • C12N2760/16134Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein

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  • Health & Medical Sciences (AREA)
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  • Molecular Biology (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AU2012212463A 2011-01-31 2012-01-30 Recombinant viral vectors and methods for inducing a heterosubtypic immune response to influenza A viruses Active AU2012212463B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2016235002A AU2016235002B2 (en) 2011-01-31 2016-09-30 Recombinant viral vectors and methods for inducing a heterosubtypic immune response to influenza a viruses

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161438024P 2011-01-31 2011-01-31
US61/438,024 2011-01-31
PCT/US2012/023085 WO2012106231A2 (en) 2011-01-31 2012-01-30 Recombinant viral vectors and methods for inducing a heterosubtypic immune response to influenza a viruses

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AU2012212463B2 true AU2012212463B2 (en) 2016-07-07

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US (2) US9463237B2 (enExample)
EP (1) EP2670430B1 (enExample)
JP (2) JP6169494B2 (enExample)
CN (1) CN103458922B (enExample)
AU (2) AU2012212463B2 (enExample)
WO (1) WO2012106231A2 (enExample)

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EP2670430B1 (en) * 2011-01-31 2015-04-01 Baxter International Inc Recombinant viral vectors and methods for inducing a heterosubtypic immune response to influenza a viruses
US10434166B2 (en) * 2013-03-15 2019-10-08 University Of Maryland, College Park Methods and compositions for in vivo immune stimulation and antigen production
US10286062B2 (en) 2013-07-09 2019-05-14 Texas Tech University System Universal influenza vaccine
CA3003103A1 (en) * 2015-10-22 2017-04-27 Modernatx, Inc. Broad spectrum influenza virus vaccine
PL3402802T3 (pl) * 2016-01-08 2023-06-05 Geovax, Inc. Kompozycje i sposoby generowania odpowiedzi immunologicznej względem antygenu powiązanego z guzem nowotworowym
US10370416B2 (en) * 2016-03-01 2019-08-06 Texas Tech University System Dual purpose universal influenza vaccine confers protective immunity against anthrax
KR102731582B1 (ko) 2016-06-03 2024-11-15 사노피 파스퇴르 인코포레이티드 조작된 인플루엔자 헤마글루티닌 폴리펩티드의 변형
CN107841513B (zh) * 2016-09-18 2023-04-14 中国科学院上海巴斯德研究所 基于M2e表位的广谱型流感疫苗
US10925958B2 (en) 2016-11-11 2021-02-23 Modernatx, Inc. Influenza vaccine
US11311612B2 (en) 2017-09-19 2022-04-26 Geovax, Inc. Compositions and methods for generating an immune response to treat or prevent malaria
JP7382634B2 (ja) * 2017-12-21 2023-11-17 株式会社グリーンバイオメッド 交差免疫抗原ワクチン及びその調製方法
CN109096376A (zh) * 2018-09-20 2018-12-28 扬州大学 流感病毒ha多肽、klh偶联多肽及多克隆抗体的制备方法
CN113004422B (zh) * 2021-03-04 2023-01-20 辽宁成大生物股份有限公司 一种融合蛋白、含其的疫苗及其应用
WO2023019274A1 (en) * 2021-08-13 2023-02-16 Purdue Research Foundation Methods and compositions for vaccination against heterosubtypic influenza viruses using an adenoviral vector leading to enhanced t cell response through autophagy

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WO2010117786A1 (en) * 2009-03-30 2010-10-14 Mount Sinai School Of Medicine Of New York University Influenza virus vaccines and uses thereof

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AT393277B (de) 1990-01-04 1991-09-25 Immuno Ag Verfahren zur herstellung von fruehsommer- meningoenzephalitis-virus (fsme-virus)-antigen
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Publication number Publication date
JP6169494B2 (ja) 2017-07-26
WO2012106231A3 (en) 2012-09-20
WO2012106231A2 (en) 2012-08-09
AU2016235002B2 (en) 2018-08-09
EP2670430B1 (en) 2015-04-01
US10329583B2 (en) 2019-06-25
US9463237B2 (en) 2016-10-11
EP2670430A2 (en) 2013-12-11
JP2017221195A (ja) 2017-12-21
US20170121735A1 (en) 2017-05-04
JP6461244B2 (ja) 2019-01-30
CN103458922B (zh) 2017-10-03
CN103458922A (zh) 2013-12-18
US20140050759A1 (en) 2014-02-20
JP2014506785A (ja) 2014-03-20
AU2012212463A1 (en) 2013-05-02
AU2016235002A1 (en) 2016-10-27

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