CN103458895B - 罗替戈汀、其衍生物或罗替戈汀或其衍生物药用盐的组合物 - Google Patents

罗替戈汀、其衍生物或罗替戈汀或其衍生物药用盐的组合物 Download PDF

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CN103458895B
CN103458895B CN201180049447.2A CN201180049447A CN103458895B CN 103458895 B CN103458895 B CN 103458895B CN 201180049447 A CN201180049447 A CN 201180049447A CN 103458895 B CN103458895 B CN 103458895B
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plga
acid
content
rotigotine
microsphere composition
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Chinese (zh)
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CN103458895A (zh
Inventor
王爱萍
李又欣
刘万卉
孙考祥
李军
孙丽芳
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Green Leaf Jiaao Pharmaceutical Shijiazhuang Co ltd
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Shandong Luye Pharmaceutical Co Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Inorganic Chemistry (AREA)
  • Psychology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CN201180049447.2A 2010-11-25 2011-11-25 罗替戈汀、其衍生物或罗替戈汀或其衍生物药用盐的组合物 Active CN103458895B (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201180049447.2A CN103458895B (zh) 2010-11-25 2011-11-25 罗替戈汀、其衍生物或罗替戈汀或其衍生物药用盐的组合物

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
CN201010576447.5 2010-11-25
CN201010576447 2010-11-25
PCT/CN2011/001958 WO2012068783A1 (en) 2010-11-25 2011-11-25 Compositions of rotigotine, derivatives thereof, or pharmaceutically acceptable salts of rotigotine or its derivative
CN201180049447.2A CN103458895B (zh) 2010-11-25 2011-11-25 罗替戈汀、其衍生物或罗替戈汀或其衍生物药用盐的组合物

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CN103458895A CN103458895A (zh) 2013-12-18
CN103458895B true CN103458895B (zh) 2014-07-09

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US (1) US9265835B2 (enExample)
EP (1) EP2642993B1 (enExample)
JP (2) JP6006225B2 (enExample)
KR (1) KR101481643B1 (enExample)
CN (1) CN103458895B (enExample)
AU (1) AU2011334494B2 (enExample)
BR (1) BR112013012726B1 (enExample)
CA (1) CA2816288C (enExample)
ES (1) ES2572948T3 (enExample)
MY (1) MY165003A (enExample)
PH (1) PH12013500923A1 (enExample)
PL (1) PL2642993T3 (enExample)
RU (1) RU2589700C2 (enExample)
WO (1) WO2012068783A1 (enExample)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8682462B2 (en) 2011-08-13 2014-03-25 Colin M. Leonard Systems and methods for dynamic audio processing
US11074031B1 (en) 2016-09-06 2021-07-27 Colin Leonard Systems and methods for dynamic audio processing
EP2559435A1 (en) 2011-08-19 2013-02-20 UCB Pharma GmbH Rotigotine in the treatment of hemispatial neglect, stroke and deficits following stroke
KR101558042B1 (ko) * 2012-07-05 2015-10-07 에스케이케미칼주식회사 로티고틴을 함유한 경피흡수제제
AU2014375268B2 (en) * 2013-12-31 2019-11-14 Pb & B Sa Controlled release fatty acid compositions for use in body reconstruction and body-shaping
CN105310974B (zh) * 2014-08-01 2019-08-23 山东绿叶制药有限公司 罗替戈汀及其衍生物或其药用盐的植入剂
CN106474070B (zh) * 2015-08-26 2020-03-17 四川科伦药物研究院有限公司 一种克服停滞期、恒速释放疏水性药物的微球及制备方法
CN105963253A (zh) * 2016-06-19 2016-09-28 朱武欣 一种罗替戈汀长效水性混悬型注射剂
ES2855976T3 (es) 2016-07-21 2021-09-27 Shandong luye pharmaceutical co ltd Behenato de rotigotina y procedimiento de fabricación y aplicación del mismo
WO2018045000A1 (en) 2016-08-30 2018-03-08 Dow Agrosciences Llc Picolinamides as fungicides
WO2018096560A1 (en) 2016-11-23 2018-05-31 Cipla Limited Long acting depot formulation for the continuous dopaminergic stimulation
KR102089737B1 (ko) * 2017-11-01 2020-03-16 한국화학연구원 에씨탈로프람을 함유한 미립구형 서방출 주사제 및 그의 제조방법
KR102181231B1 (ko) * 2018-11-22 2020-11-20 주식회사 메디포럼제약 로티고틴 함유 고분자 미립자의 제조방법
CN115484935A (zh) * 2020-02-14 2022-12-16 G2G生物公司 包括含有glp-1类似物或其药学上可接受的盐的缓释微球的药物组合物

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1762495A (zh) * 2004-09-21 2006-04-26 山东绿叶制药有限公司 含有多巴胺受体激动剂类药物的长效缓释制剂及其制备工艺
CN101467959A (zh) * 2007-12-27 2009-07-01 财团法人工业技术研究院 持续释放组合物及其制备方法

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GB9718986D0 (en) * 1997-09-09 1997-11-12 Danbiosyst Uk Controlled release microsphere delivery system
DE10234673B4 (de) * 2002-07-30 2007-08-16 Schwarz Pharma Ag Heißschmelz-TTS zur Verabreichung von Rotigotin und Verfahren zu seiner Herstellung sowie Verwendung von Rotigotin bei der Herstellung eines TTS im Heißschmelzverfahren
CA2574085C (en) * 2004-07-16 2014-02-11 Oakwood Laboratories, L.L.C. Gonadotropin releasing hormone antagonists
US8691277B2 (en) 2004-09-21 2014-04-08 Shandong Luye Pharmaceutical Co., Ltd. Long acting sustained-release formulation containing dopamine receptor agonist and the preparation method thereof

Patent Citations (2)

* Cited by examiner, † Cited by third party
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CN1762495A (zh) * 2004-09-21 2006-04-26 山东绿叶制药有限公司 含有多巴胺受体激动剂类药物的长效缓释制剂及其制备工艺
CN101467959A (zh) * 2007-12-27 2009-07-01 财团法人工业技术研究院 持续释放组合物及其制备方法

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
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《PLGA微球注射剂的研究进展》;高秀娟等;《大连理工大学生物医学工程学术论文集》;20051231;第2卷;第418页倒数第2段至第419页第段 *

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Publication number Publication date
JP6006225B2 (ja) 2016-10-12
US9265835B2 (en) 2016-02-23
ES2572948T3 (es) 2016-06-03
MY165003A (en) 2018-02-28
PL2642993T3 (pl) 2016-09-30
BR112013012726A2 (enExample) 2017-04-04
AU2011334494B2 (en) 2015-11-05
JP2016028043A (ja) 2016-02-25
KR20130130727A (ko) 2013-12-02
JP2013543874A (ja) 2013-12-09
US20140377369A2 (en) 2014-12-25
RU2589700C2 (ru) 2016-07-10
JP6067803B2 (ja) 2017-01-25
EP2642993A4 (en) 2014-05-14
RU2013128430A (ru) 2014-12-27
EP2642993B1 (en) 2016-03-02
EP2642993A1 (en) 2013-10-02
HK1186978A1 (en) 2014-03-28
PH12013500923A1 (en) 2016-02-08
KR101481643B1 (ko) 2015-01-12
US20130309314A1 (en) 2013-11-21
AU2011334494A1 (en) 2013-07-11
CN103458895A (zh) 2013-12-18
CA2816288A1 (en) 2012-05-31
WO2012068783A1 (en) 2012-05-31
BR112013012726B1 (pt) 2022-03-29
CA2816288C (en) 2016-01-26

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