CN103430026A - 急性肺损伤的诊断方法 - Google Patents
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Abstract
Description
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PCT/JP2012/053174 WO2012108538A1 (ja) | 2011-02-10 | 2012-02-10 | 急性肺損傷診断方法 |
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CN103430026A true CN103430026A (zh) | 2013-12-04 |
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EP (1) | EP2674755B1 (zh) |
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CN (1) | CN103430026B (zh) |
WO (1) | WO2012108538A1 (zh) |
Cited By (1)
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CN112710847A (zh) * | 2020-12-17 | 2021-04-27 | 温州医科大学慈溪生物医药研究院 | Apelin蛋白在制备诊断呼吸系统疾病试剂的应用 |
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CA2774383A1 (en) | 2011-06-22 | 2012-12-22 | Shaf Keshavjee | Repaired organ and method for making the same |
KR101468047B1 (ko) * | 2013-01-16 | 2014-12-02 | 고려대학교 산학협력단 | 열충격단백질군의 mRNA 발현 양상 분석을 통한 사인 추정방법 |
AU2017313138B2 (en) * | 2016-08-17 | 2024-01-04 | The Regents Of The University Of California | A novel immunoprobe-based method to assess organ injury status through a biofluid-based cell-free DNA (cfDNA) assay |
JP2019116507A (ja) * | 2019-04-25 | 2019-07-18 | 有限会社オービット | Hsp47の発現促進剤、脱毛抑制方法、Hsp47の発現促進剤の製造方法及び飲食物の製造方法 |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH08301757A (ja) * | 1995-05-10 | 1996-11-19 | Kureha Chem Ind Co Ltd | Hsp47合成抑制剤 |
JP2006519774A (ja) * | 2003-02-21 | 2006-08-31 | ジェネンテック・インコーポレーテッド | 癌の治療のための組成物と方法 |
CN101102795A (zh) * | 2004-12-22 | 2008-01-09 | 北海道公立大学法人札幌医科大学 | 用于抑制纤维化的药物载体和药物载体试剂盒 |
JP2008122276A (ja) * | 2006-11-14 | 2008-05-29 | Kitasato Gakuen | コラーゲン特異的分子シャペロンhsp47の測定方法 |
WO2009033284A1 (en) * | 2007-09-14 | 2009-03-19 | Mcmaster University | Inhibitors of collagen biosynthesis as anti-tumor agents |
WO2009103542A1 (en) * | 2008-02-22 | 2009-08-27 | Mubio Products Bv | Small cell lung carcinoma biomarker panel |
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JP3156857B2 (ja) * | 1991-07-04 | 2001-04-16 | 株式会社日立製作所 | 核磁気共鳴を用いた検査装置 |
JPH08240593A (ja) * | 1995-03-06 | 1996-09-17 | Kureha Chem Ind Co Ltd | Hsp47の検出方法及び悪性腫瘍転移性検査試薬 |
US6190857B1 (en) * | 1997-03-24 | 2001-02-20 | Urocor, Inc. | Diagnosis of disease state using MRNA profiles in peripheral leukocytes |
CA2340176A1 (en) | 1998-08-13 | 2000-02-24 | Hadasit Medical Research Services And Development Company Ltd. | Inhibition of pathogenic processes related to tissue trauma |
EP1425412A2 (en) * | 2000-11-28 | 2004-06-09 | University Of Cincinnati | Blood assessment of injury |
JP2003159087A (ja) | 2001-09-13 | 2003-06-03 | Japan Science & Technology Corp | 組織線維化抑制オリゴヌクレオチド |
JP2011027679A (ja) | 2009-07-29 | 2011-02-10 | Osaki Electric Co Ltd | 電流検出器 |
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2012
- 2012-02-10 EP EP12744724.1A patent/EP2674755B1/en not_active Not-in-force
- 2012-02-10 CN CN201280014503.3A patent/CN103430026B/zh not_active Expired - Fee Related
- 2012-02-10 JP JP2012556945A patent/JP5966227B2/ja active Active
- 2012-02-10 US US13/984,623 patent/US20130323763A1/en not_active Abandoned
- 2012-02-10 WO PCT/JP2012/053174 patent/WO2012108538A1/ja active Application Filing
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH08301757A (ja) * | 1995-05-10 | 1996-11-19 | Kureha Chem Ind Co Ltd | Hsp47合成抑制剤 |
JP2006519774A (ja) * | 2003-02-21 | 2006-08-31 | ジェネンテック・インコーポレーテッド | 癌の治療のための組成物と方法 |
CN101102795A (zh) * | 2004-12-22 | 2008-01-09 | 北海道公立大学法人札幌医科大学 | 用于抑制纤维化的药物载体和药物载体试剂盒 |
JP2008122276A (ja) * | 2006-11-14 | 2008-05-29 | Kitasato Gakuen | コラーゲン特異的分子シャペロンhsp47の測定方法 |
WO2009033284A1 (en) * | 2007-09-14 | 2009-03-19 | Mcmaster University | Inhibitors of collagen biosynthesis as anti-tumor agents |
WO2009103542A1 (en) * | 2008-02-22 | 2009-08-27 | Mubio Products Bv | Small cell lung carcinoma biomarker panel |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN112710847A (zh) * | 2020-12-17 | 2021-04-27 | 温州医科大学慈溪生物医药研究院 | Apelin蛋白在制备诊断呼吸系统疾病试剂的应用 |
CN112710847B (zh) * | 2020-12-17 | 2022-04-08 | 温州医科大学慈溪生物医药研究院 | Apelin蛋白在制备诊断呼吸系统疾病试剂的应用 |
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CN103430026B (zh) | 2016-01-27 |
EP2674755A4 (en) | 2014-12-03 |
EP2674755A1 (en) | 2013-12-18 |
WO2012108538A1 (ja) | 2012-08-16 |
JPWO2012108538A1 (ja) | 2014-07-03 |
JP5966227B2 (ja) | 2016-08-10 |
EP2674755B1 (en) | 2017-07-26 |
US20130323763A1 (en) | 2013-12-05 |
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