CN103385906A - Drug for shortening sow labor process and preparation method thereof - Google Patents
Drug for shortening sow labor process and preparation method thereof Download PDFInfo
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- CN103385906A CN103385906A CN2013103047378A CN201310304737A CN103385906A CN 103385906 A CN103385906 A CN 103385906A CN 2013103047378 A CN2013103047378 A CN 2013103047378A CN 201310304737 A CN201310304737 A CN 201310304737A CN 103385906 A CN103385906 A CN 103385906A
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Abstract
The invention discloses a drug for shortening a sow labor process and a preparation method thereof. The preparation method comprises the following steps of adding 88.8806-88.8810% of injection water into a concentration tank, carrying out stirring, slowly adding 0.1-0.3% of metronidazole into the concentration tank, carrying out heating boiling, adding 9-11% of weighed glucose, 0.008-0.012% of triphosadenine, 0.006-0.01% of dexamethasone and 0.8-1.0% of common salt into the boiling solution until complete dissolution, adding active carbon of which humidity is pre-adjusted into the mixed solution for decoloration, filtering the hot mixed solution by a concentration and filtration titanium rod, collecting the filtrate by a dilution tank, carrying out stirring by the dilution tank, diluting the filtrate by injection water until the diluent filtrate volume is 90% of the total dilution tank volume, adjusting a pH value to 6.0-7.0 by a sodium hydroxide solution having the content of 0.1mol/L, carrying out dilution until the diluent filtrate volume is equal to the total dilution tank volume, adding active carbon of which humidity is pre-adjusted into the diluent filtrate for decoloration, carrying out filtration by a filter membrane until the filtrate is clear and transparent, feeding the filtrate to a soft bag liquid-conveying production line by a delivery pump, and carrying out loading.
Description
Technical field
The present invention relates to a kind of medicine, relate in particular to a kind of medicine that shortens the sow stages of labor.The invention still further relates to the preparation method of the medicine of this shortening sow stages of labor.
Background technology
At present, disclose a kind of like this medicine that shortens the sow stages of labor on market, primary raw material is oxytocin inj.Energy selective excitement uterus, strengthen the contraction of uterine smooth muscle.Its excited uterine smooth muscle effect is different because of dosage size, hormone in vivo level.The low dose of rhythmicity that can increase uterus muscle third trimester of pregnancy is shunk, and the contraction diastole is even; Heavy dose can cause the contraction of the tetanic property of uterine smooth muscle, makes the blood vessel in myometrium suffer oppression and play the hemostasis effect.In addition, oxytocin can promote the myoepithelial cell around mammary gland alveolus and gland conduit to shrink, and promotes milk ejection.Be used for hastening parturition, puerperal metrorrhagia, placenta retention and promote milk ejection etc.Stages of labor is long, white stillborn fetus is higher, anti-inflammation is poor, appetite is recovered slower phenomenon but exist.
Summary of the invention
The purpose of this invention is to provide a kind ofly shorten stages of labor, reduce white stillborn fetus, anti-inflammation is more satisfactory, recover as soon as possible the medicine of the shortening sow stages of labor of appetite.
For achieving the above object, a kind of medicine that shortens the sow stages of labor of the present invention, it is the medicine of being made by the raw material of following weight proportioning
Glucose 9-11% adenosine triphosphate 0.008-0.012% DIMI 0.006-0.01% neostigmine methylsulfate 0.0010-0.0014% metronidazole 0.1-0.3% sodium chloride 0.8-1.0% water for injection 88.8806-88.8810%.
Wherein the proportioning of each raw material weight is
Glucose 10% adenosine triphosphate 0.01% DIMI 0.008% neostigmine methylsulfate 0.0012% metronidazole 0.2% sodium chloride 0.9% water for injection 88.8808%.
A kind of process for preparing medicine that shortens the sow stages of labor, the method comprises the step of following order:
(1) first water for injection was rinsed 10 minutes the dense preparing tank inwall, and open delivery pump, systemic circulation was cleaned 10 minutes, cleaned complete water is drained and closes, and rinsed the washing liquid merging of dense preparing tank and paddle and has filtered into connected dilute preparing tank,
(2) then add water for injection 88.8806-88.8810% in dense preparing tank, open the interlayer inlet valve, regulate the solidifying water valve of steam discharge, open and stir, slowly add metronidazole 0.1-0.3%, intensification is boiled,
(3) after raw material dissolves fully, add the glucose 9-11%, adenosine triphosphate 0.008-0.012%, DIMI 0.006-0.01%, sodium chloride 0.8-1.0% of load weighted recipe quantity to dissolving fully, the active carbon that adds damping in advance, decoloured 15 minutes
(4) then filter dilute preparing tank (after systemic circulation is cleaned, with water for injection, rinse the dilute preparing tank inwall before material charging every day first, rinse and complete water is drained, close bottom valve, be stand-by) through dense filter titanium rod while hot,
(5) open dilute preparing tank and stir, with water for injection, be diluted to 90% of material cumulative volume, and with the sodium hydroxide solution of 0.1mol/L, regulate pH value to 6.0～7.0,
(6) be diluted to material cumulative volume 100% with water for injection again,
(7) add subsequently the active carbon of damping in advance, decoloured 15 minutes,
(8) finally by membrane filtration to clear, deliver to soft bag infusion production line through delivery pump, fill with detecting qualified medicinal liquid.
Said boiling time is 10 minutes.
The active carbon that adds damping in advance is 50% of the total input amount of material.
With 0.22um filtering with microporous membrane solution 30 minutes.
The pouring process fluid temperature remains 50-70 ℃, and the filling time is no more than 5 hours.
The present invention has following advantage:
(1) shorten stages of labor: supplement the uterus rhythmicity and shrink required energy and special dietary composition, keep the normal physiological function in uterus, can greatly reduce the generation that causes white stillborn fetus phenomenon because stages of labor is long.
(2) anti-inflammation: optimize antibacterial combination, has a broad antifungal spectrum, antiphlogistic effects is good.
(3) recover appetite: impel sow to recover as early as possible appetite puerperal, and reduce the syndromic generation of anorexia in puerperal.
The specific embodimentBelow in conjunction with embodiment, the present invention is further described.
Embodiment one:
first water for injection was rinsed 10 minutes the dense preparing tank inwall, and unlatching delivery pump, systemic circulation was cleaned 10 minutes, clean and complete water is drained and closes, the washing liquid of having rinsed dense preparing tank and paddle merges filters into connected dilute preparing tank, then add water for injection 88.8808% in dense preparing tank, open the interlayer inlet valve, make steam enter dense preparing tank, regulate the solidifying water valve of steam discharge, open and stir, slowly add metronidazole 0.2%, intensification is boiled, boiling time is 10 minutes, after raw material dissolves fully, add load weighted glucose 10%, adenosine triphosphate 0.012%, DIMI 0.008%, sodium chloride 0.9% is to dissolving fully, 50% the active carbon for the total input amount of material that adds damping in advance, decoloured 15 minutes, (material charging every day first is front after systemic circulation is cleaned then to filter dilute preparing tank through dense filter titanium rod while hot, rinse the dilute preparing tank inwall with water for injection, rinse and complete water is drained, close bottom valve, stand-by), the unlatching dilute preparing tank stirs, be diluted to 90% of material cumulative volume with water for injection, and with the sodium hydroxide solution of 0.1mol/L, regulate pH value to 6.0～7.0, be diluted to material cumulative volume 100% with water for injection again, 50% the active carbon for the total input amount of material that adds subsequently damping in advance, decoloured 15 minutes, finally by 0.22um filtering with microporous membrane 30 minutes to clear, deliver to soft bag infusion production line with detecting qualified medicinal liquid through delivery pump, the pouring process fluid temperature remains 50-70 ℃, filling time is no more than 5 hours.
Embodiment two
first water for injection was rinsed 10 minutes the dense preparing tank inwall, and unlatching delivery pump, systemic circulation was cleaned 10 minutes, clean and complete water is drained and closes, the washing liquid of having rinsed dense preparing tank and paddle merges filters into connected dilute preparing tank, then add water for injection 88.8806% in dense preparing tank, open the interlayer inlet valve, make steam enter dense preparing tank, regulate the solidifying water valve of steam discharge, open and stir, slowly add metronidazole 0.3%, intensification is boiled, boiling time is 10 minutes, after raw material dissolves fully, add load weighted glucose 9%, adenosine triphosphate 0.008%, DIMI 0.01%, sodium chloride 1.0% is to dissolving fully, 50% the active carbon for the total input amount of material that adds damping in advance, decoloured 15 minutes, (material charging every day first is front after systemic circulation is cleaned then to filter dilute preparing tank through dense filter titanium rod while hot, rinse the dilute preparing tank inwall with water for injection, rinse and complete water is drained, close bottom valve, stand-by), the unlatching dilute preparing tank stirs, be diluted to 90% of material cumulative volume with water for injection, and with the sodium hydroxide solution of 0.1mol/L, regulate pH value to 6.0～7.0, be diluted to material cumulative volume 100% with water for injection again, 50% the active carbon for the total input amount of material that adds subsequently damping in advance, decoloured 15 minutes, finally by 0.22um filtering with microporous membrane 30 minutes to clear, deliver to soft bag infusion production line with detecting qualified medicinal liquid through delivery pump, the pouring process fluid temperature remains 50-70 ℃, filling time is no more than 5 hours.
Embodiment three
first water for injection was rinsed 10 minutes the dense preparing tank inwall, and unlatching delivery pump, systemic circulation was cleaned 10 minutes, clean and complete water is drained and closes, the washing liquid of having rinsed dense preparing tank and paddle merges filters into connected dilute preparing tank, then add water for injection 88.8810% in dense preparing tank, open the interlayer inlet valve, make steam enter dense preparing tank, regulate the solidifying water valve of steam discharge, open and stir, slowly add metronidazole 0.1%, intensification is boiled, boiling time is 10 minutes, after raw material dissolves fully, add load weighted glucose 11%, adenosine triphosphate 0.01%, DIMI 0.006%, sodium chloride 0.8% is to dissolving fully, 50% the active carbon for the total input amount of material that adds damping in advance, decoloured 15 minutes, (material charging every day first is front after systemic circulation is cleaned then to filter dilute preparing tank through dense filter titanium rod while hot, rinse the dilute preparing tank inwall with water for injection, rinse and complete water is drained, close bottom valve, stand-by), the unlatching dilute preparing tank stirs, be diluted to 90% of material cumulative volume with water for injection, and with the sodium hydroxide solution of 0.1mol/L, regulate pH value to 6.0～7.0, be diluted to material cumulative volume 100% with water for injection again, 50% the active carbon for the total input amount of material that adds subsequently damping in advance, decoloured 15 minutes, finally by 0.22um filtering with microporous membrane 30 minutes to clear, deliver to soft bag infusion production line with detecting qualified medicinal liquid through delivery pump, the pouring process fluid temperature remains 50-70 ℃, filling time is no more than 5 hours.
Embodiment four
first water for injection was rinsed 10 minutes the dense preparing tank inwall, and unlatching delivery pump, systemic circulation was cleaned 10 minutes, clean and complete water is drained and closes, the washing liquid of having rinsed dense preparing tank and paddle merges filters into connected dilute preparing tank, then add water for injection 88.8810% in dense preparing tank, open the interlayer inlet valve, make steam enter dense preparing tank, regulate the solidifying water valve of steam discharge, open and stir, slowly add metronidazole 0.1%, intensification is boiled, boiling time is 10 minutes, after raw material dissolves fully, add load weighted glucose 9%, adenosine triphosphate 0.012%, DIMI 0.01%, sodium chloride 1.0% is to dissolving fully, 50% the active carbon for the total input amount of material that adds damping in advance, decoloured 15 minutes, (material charging every day first is front after systemic circulation is cleaned then to filter dilute preparing tank through dense filter titanium rod while hot, rinse the dilute preparing tank inwall with water for injection, rinse and complete water is drained, close bottom valve, stand-by), the unlatching dilute preparing tank stirs, be diluted to 90% of material cumulative volume with water for injection, and with the sodium hydroxide solution of 0.1mol/L, regulate pH value to 6.0～7.0, be diluted to material cumulative volume 100% with water for injection again, 50% the active carbon for the total input amount of material that adds subsequently damping in advance, decoloured 15 minutes, finally by 0.22um filtering with microporous membrane 30 minutes to clear, deliver to soft bag infusion production line with detecting qualified medicinal liquid through delivery pump, the pouring process fluid temperature remains 50-70 ℃, filling time is no more than 5 hours.
Embodiment five
first water for injection was rinsed 10 minutes the dense preparing tank inwall, and unlatching delivery pump, systemic circulation was cleaned 10 minutes, clean and complete water is drained and closes, the washing liquid of having rinsed dense preparing tank and paddle merges filters into connected dilute preparing tank, then add water for injection 88.8806% in dense preparing tank, open the interlayer inlet valve, make steam enter dense preparing tank, regulate the solidifying water valve of steam discharge, open and stir, slowly add metronidazole 0.1%, intensification is boiled, boiling time is 10 minutes, after raw material dissolves fully, add load weighted glucose 11%, adenosine triphosphate 0.008%, DIMI 0.006%, sodium chloride 0.8% is to dissolving fully, 50% the active carbon for the total input amount of material that adds damping in advance, decoloured 15 minutes, (material charging every day first is front after systemic circulation is cleaned then to filter dilute preparing tank through dense filter titanium rod while hot, rinse the dilute preparing tank inwall with water for injection, rinse and complete water is drained, close bottom valve, stand-by), the unlatching dilute preparing tank stirs, be diluted to 90% of material cumulative volume with water for injection, and with the sodium hydroxide solution of 0.1mol/L, regulate pH value to 6.0～7.0, be diluted to material cumulative volume 100% with water for injection again, 50% the active carbon for the total input amount of material that adds subsequently damping in advance, decoloured 15 minutes, finally by 0.22um filtering with microporous membrane 30 minutes to clear, deliver to soft bag infusion production line with detecting qualified medicinal liquid through delivery pump, the pouring process fluid temperature remains 50-70 ℃, filling time is no more than 5 hours.
Above embodiment effect:
Table one: experimental result statistical table:
Claims (7)
1. a medicine that shortens the sow stages of labor, is characterized in that it is the medicine of being made by the raw material of following weight proportioning
Glucose 9-11% adenosine triphosphate 0.008-0.012% DIMI 0.006-0.01% neostigmine methylsulfate 0.0010-0.0014% metronidazole 0.1-0.3% sodium chloride 0.8-1.0% water for injection 88.8806-88.8810%.
2. a kind of medicine that shortens the sow stages of labor according to claim 1, wherein the proportioning of each raw material weight is
Glucose 10% adenosine triphosphate 0.01% DIMI 0.008% neostigmine methylsulfate 0.0012% metronidazole 0.2% sodium chloride 0.9% water for injection 88.8808%.
3. process for preparing medicine that shortens the sow stages of labor, the method comprises the step of following order:
(1) first water for injection was rinsed 10 minutes the dense preparing tank inwall, and open delivery pump, systemic circulation was cleaned 10 minutes, cleaned complete water is drained and closes, and rinsed the washing liquid merging of dense preparing tank and paddle and has filtered into connected dilute preparing tank,
(2) then add water for injection 88.8806-88.8810% in dense preparing tank, open the interlayer inlet valve, regulate the solidifying water valve of steam discharge, open and stir, slowly add metronidazole 0.1-0.3%, intensification is boiled,
(3) after raw material dissolves fully, add the glucose 9-11%, adenosine triphosphate 0.008-0.012%, DIMI 0.006-0.01%, sodium chloride 0.8-1.0% of load weighted recipe quantity to dissolving fully, the active carbon that adds damping in advance, decoloured 15 minutes
(4) then filter dilute preparing tank (after systemic circulation is cleaned, with water for injection, rinse the dilute preparing tank inwall before material charging every day first, rinse and complete water is drained, close bottom valve, be stand-by) through dense filter titanium rod while hot,
(5) open dilute preparing tank and stir, with water for injection, be diluted to 90% of material cumulative volume, and with the sodium hydroxide solution of 0.1mol/L, regulate pH value to 6.0～7.0,
(6) be diluted to material cumulative volume 100% with water for injection again,
(7) add subsequently the active carbon of damping in advance, decoloured 15 minutes,
(8) finally by membrane filtration to clear, deliver to soft bag infusion production line through delivery pump, fill with detecting qualified medicinal liquid.
4. a kind of process for preparing medicine that shortens the sow stages of labor according to claim 3, is characterized in that said boiling time is 10 minutes.
5. a kind of process for preparing medicine that shortens the sow stages of labor according to claim 3, the active carbon that it is characterized in that adding damping in advance is 50% of the total input amount of material.
6. a kind of process for preparing medicine that shortens the sow stages of labor according to claim 3, is characterized in that using 0.22um filtering with microporous membrane solution 30 minutes.
7. a kind of process for preparing medicine that shortens the sow stages of labor according to claim 3, is characterized in that the pouring process fluid temperature remains 50-70 ℃, and the filling time is no more than 5 hours.
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| CN201310304737.8A CN103385906B (en) | 2013-07-19 | 2013-07-19 | A kind of medicine shortening sow stages of labor and preparation method thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105395480A (en) * | 2015-12-25 | 2016-03-16 | 成都巨星农牧科技有限公司 | Glucose solution |
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| CN1156591A (en) * | 1996-02-06 | 1997-08-13 | 钱嘉达 | Oxytocic aid for fishes and hasten parturition method thereof |
| CN1730097A (en) * | 2005-07-25 | 2006-02-08 | 华中农业大学 | Pharmaceutical composition for preventing and curing endometritis and retained afterbirth disease of milk cow |
| CN101480396A (en) * | 2008-01-07 | 2009-07-15 | 中国水产科学研究院东海水产研究所 | Spawning-induced addition agent for artificial propagation of sea water fish |
| CN102919570A (en) * | 2012-10-25 | 2013-02-13 | 淮安正昌饲料有限公司 | Special gestation compound feed for sows at later stage of pregnancy and preparation method thereof |
-
2013
- 2013-07-19 CN CN201310304737.8A patent/CN103385906B/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1156591A (en) * | 1996-02-06 | 1997-08-13 | 钱嘉达 | Oxytocic aid for fishes and hasten parturition method thereof |
| CN1730097A (en) * | 2005-07-25 | 2006-02-08 | 华中农业大学 | Pharmaceutical composition for preventing and curing endometritis and retained afterbirth disease of milk cow |
| CN101480396A (en) * | 2008-01-07 | 2009-07-15 | 中国水产科学研究院东海水产研究所 | Spawning-induced addition agent for artificial propagation of sea water fish |
| CN102919570A (en) * | 2012-10-25 | 2013-02-13 | 淮安正昌饲料有限公司 | Special gestation compound feed for sows at later stage of pregnancy and preparation method thereof |
Non-Patent Citations (1)
| Title |
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| 夏伟斌: "催产素合并地塞米松治疗母猪过期不产效果好", 《畜牧与兽医》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105395480A (en) * | 2015-12-25 | 2016-03-16 | 成都巨星农牧科技有限公司 | Glucose solution |
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Address after: 364000, Fujian Longyan Industrial Zone, Xinluo District, Longzhou Zhang Bai area high-tech zone Applicant after: Fujian Ao Mulong biological engineering company limited Address before: 364000, Fujian Longyan Industrial Zone, Xinluo District, Longzhou Zhang Bai area high-tech zone Applicant before: Fujian Aomron Animal Pharmaceutical Co., Ltd. |
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Denomination of invention: A medicine for shortening sow labor process and its preparation method Effective date of registration: 20210520 Granted publication date: 20160810 Pledgee: Societe Generale Bank Limited by Share Ltd. Longyan branch Pledgor: FUJIAN AOMRON BIOLOGICAL ENGINEERING Co.,Ltd. Registration number: Y2021980003842 |
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