CN103860604A - Compound tablet containing kelp extract and cordyceps militaris - Google Patents
Compound tablet containing kelp extract and cordyceps militaris Download PDFInfo
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- CN103860604A CN103860604A CN201310677736.8A CN201310677736A CN103860604A CN 103860604 A CN103860604 A CN 103860604A CN 201310677736 A CN201310677736 A CN 201310677736A CN 103860604 A CN103860604 A CN 103860604A
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- thallus
- cordyceps militaris
- extract
- thallus laminariae
- eckloniae
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- 241001264174 Cordyceps militaris Species 0.000 title claims abstract description 34
- 150000001875 compounds Chemical class 0.000 title claims abstract description 13
- 241000512259 Ascophyllum nodosum Species 0.000 title abstract 8
- 239000000654 additive Substances 0.000 claims abstract description 11
- 230000000996 additive effect Effects 0.000 claims abstract description 11
- 238000000034 method Methods 0.000 claims abstract description 5
- 239000002131 composite material Substances 0.000 claims description 15
- 238000002360 preparation method Methods 0.000 claims description 9
- 239000013535 sea water Substances 0.000 claims description 8
- 239000007788 liquid Substances 0.000 claims description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 7
- 239000000843 powder Substances 0.000 claims description 6
- 239000000203 mixture Substances 0.000 claims description 5
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 4
- 230000007935 neutral effect Effects 0.000 claims description 4
- 235000021110 pickles Nutrition 0.000 claims description 4
- XAEFZNCEHLXOMS-UHFFFAOYSA-M potassium benzoate Chemical compound [K+].[O-]C(=O)C1=CC=CC=C1 XAEFZNCEHLXOMS-UHFFFAOYSA-M 0.000 claims description 4
- 238000001556 precipitation Methods 0.000 claims description 4
- 238000010298 pulverizing process Methods 0.000 claims description 4
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- 241000208340 Araliaceae Species 0.000 claims description 3
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 claims description 3
- 235000003140 Panax quinquefolius Nutrition 0.000 claims description 3
- 235000008434 ginseng Nutrition 0.000 claims description 3
- 150000004676 glycans Chemical class 0.000 abstract description 12
- 229920001282 polysaccharide Polymers 0.000 abstract description 12
- 239000005017 polysaccharide Substances 0.000 abstract description 12
- 208000017169 kidney disease Diseases 0.000 abstract description 9
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- 238000002474 experimental method Methods 0.000 abstract description 3
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- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 3
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- 241001474374 Blennius Species 0.000 description 2
- SHZGCJCMOBCMKK-UHFFFAOYSA-N D-mannomethylose Natural products CC1OC(O)C(O)C(O)C1O SHZGCJCMOBCMKK-UHFFFAOYSA-N 0.000 description 2
- 208000007342 Diabetic Nephropathies Diseases 0.000 description 2
- PNNNRSAQSRJVSB-SLPGGIOYSA-N Fucose Natural products C[C@H](O)[C@@H](O)[C@H](O)[C@H](O)C=O PNNNRSAQSRJVSB-SLPGGIOYSA-N 0.000 description 2
- SHZGCJCMOBCMKK-DHVFOXMCSA-N L-fucopyranose Chemical compound C[C@@H]1OC(O)[C@@H](O)[C@H](O)[C@@H]1O SHZGCJCMOBCMKK-DHVFOXMCSA-N 0.000 description 2
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 2
- 229920000615 alginic acid Polymers 0.000 description 2
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- 206010020710 Hyperphagia Diseases 0.000 description 1
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- 239000003472 antidiabetic agent Substances 0.000 description 1
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Images
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- Medicines Containing Plant Substances (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
The invention discloses a compound tablet containing a kelp extract and cordyceps militaris. The compound tablet comprises the following components in percentage by weight: 10-45% of the kelp extract, 10-45% of cordyceps militaris and 5-30% of an additive. A method for preparing the compound tablet containing kelp extract and cordyceps militaris comprises the following steps: (1) preparing the kelp extract; (2) adding cordyceps militaris into the kelp extract prepared in the step (1); and (3) adding the additive and tabletting a compound sugar-tablet. By extracting polysaccharide substances from kelp, the cordyceps militaris is added to form complex carbohydrate, so that the compound tablet has better treatment effect on diabetes and nephropathy then medicine only containing kelp extract or the cordyceps militaris. Based on effectively exerting the effect of two natural polysaccharides of algal polysaccharide and the cordyceps militaris, the compound tablet is formed through full and accurate experiments. The effect of the compound tablet is remarkably better than that of single prescription of the algal polysaccharide and the cordyceps militaris.
Description
Technical field
The present invention relates to the composite sheet of a kind of Thallus Laminariae (Thallus Eckloniae) extract and Cordyceps militaris (L.) Link..
Background technology
Along with growth in the living standard, all there is large variation in dietary structure and daily life system time, the people of diabetes, nephropathy of so-called " affluenza " is more and more, and diabetes, nephropathy are all to belong to chronic disease, need to take medicine for a long time, serious need to beat insulin or dialysis treatment, somewhat expensive.In long-term taking, the side effect wanted of west is obvious, patient takes medicine the function that can cause toleration or injure conversely kidney for a long time.Therefore in the urgent need to a kind of stand-by food or medicine that has mitigation to have no side effect to diabetes, nephropathy simultaneously.The food compound prescription of the low side effect of present stage to diabetes, nephropathy does not exist substantially.
Summary of the invention
Technical problem to be solved by this invention is: the composite sheet of a kind of Thallus Laminariae (Thallus Eckloniae) extract and Cordyceps militaris (L.) Link. is provided, is used for the treatment of diabetes, nephropathy.
For solving the problems of the technologies described above, the technical solution used in the present invention is:
A composite sheet for Thallus Laminariae (Thallus Eckloniae) extract and Cordyceps militaris (L.) Link., is characterized in that, comprises the composition of following weight fraction: Thallus Laminariae (Thallus Eckloniae) extract 10-45%, Cordyceps militaris (L.) Link. 10-45%, additive 5-30%.
Preferably, additive is one or more in artificial Radix Ginseng, Concha Ostreae powder, Agaricus blazei Murrill dry powder.Additive can be used as filler, jointly makes composite sheet.
The method of preparing the composite sheet of Thallus Laminariae (Thallus Eckloniae) extract and Cordyceps militaris (L.) Link., comprises the following steps:
(
1) preparation of Thallus Laminariae (Thallus Eckloniae) extract: Thallus Laminariae (Thallus Eckloniae) weight in wet base 1000kg, without pulverizing or cutting into pieces, putting into sea water heats in the large-scale steamer of 85 degrees Celsius 1 minute, take out after Thallus Laminariae (Thallus Eckloniae), go with sea water is cold, in order to prevent that in Thallus Laminariae (Thallus Eckloniae), not overflowing of polysaccharide liquid stirred, add the neutral potassium salt that is equivalent to weight in wet base Thallus Laminariae (Thallus Eckloniae) 40%, pickle 24 hours, the raising of salinity in water, can cause that Thallus Laminariae (Thallus Eckloniae) cell wall acutely shrinks, secrete a large amount of humoral substances, centrifuge dewatering obtain 300 liters of liquid that contain Thallus Laminariae (Thallus Eckloniae) extract, then add water, alcohol precipitation obtain Thallus Laminariae (Thallus Eckloniae) extract
(2) in step (1), in the Thallus Laminariae (Thallus Eckloniae) extract of preparation, add Cordyceps militaris (L.) Link.,
(3) add additive, and be pressed into compound sugar-tablet.
Thallus Laminariae (Thallus Eckloniae) extract main component is as follows:
Fucoidin sulfate: 5%-40%
Fucose
20%,
Fucoidin sulfate molecular weight at fucose molecular weight between 8000-400000 between 8000-400000
Micromolecule Algin: between 5%-25%
Micromolecule Algin: between 8000-2000000
Brown of light color.
The present invention, by after the extraction of polysaccharide material in Thallus Laminariae (Thallus Eckloniae), adds Cordyceps militaris (L.) Link., forms glycoconjugates, to the successful of diabetes, nephropathy, is better than independent use Thallus Laminariae (Thallus Eckloniae) extract or Cordyceps militaris (L.) Link.; The folk prescription that existing technology substantially all concentrates on algal polysaccharides, Cordyceps mycelium uses above, under the prerequisite of the food attribute that has kept pure natural, have no side effect, the successful of nephropathy and diabetes is better than to folk prescription.On the basis of this formula natural polysaccharide effect in effectively bringing into play seaweeds polysaccharide and Cordyceps militaris (L.) Link. two, form composite sheet by full and accurate experiment, its successful is better than the folk prescription of seaweeds polysaccharide and Cordyceps militaris (L.) Link..
Brief description of the drawings
Below in conjunction with accompanying drawing, the specific embodiment of the present invention is described in further detail.
Fig. 1 is that TK improves the heterophagous result figure of symptom to showing of diabetes rat (with matched group, P<0.05).
Fig. 2 is that TK affects result figure to the body weight of diabetes rat.
Fig. 3 is that TK slows down the result figure that increases blood glucose to diabetes rat.(*, with matched group, P <0.05)
Fig. 4 is that diabetes rat glycolated hemoglobin level is showing the result figure reducing, and TK group is than matched group (*, with matched group, P <0.05).
Fig. 5 is diabetes rat insulin secretion result figure, reduces at TK group (*, with matched group, P<0.05).
Fig. 6 is diabetes rat microdose urine protein/creatinine level result figure, and TK group is than matched group low (*, with matched group, P <0.05).
Fig. 7 is kidneys of diabetic rats section.
In figure, in bar diagram, the cylindricality of three comparisons is respectively from left to right control group, TK2% group, normal group.
Detailed description of the invention
Embodiment 1
A composite sheet for Thallus Laminariae (Thallus Eckloniae) extract and Cordyceps militaris (L.) Link., comprises the composition of following weight fraction: Thallus Laminariae (Thallus Eckloniae) extract 45%, Cordyceps militaris (L.) Link. 45%, and artificial Radix Ginseng 10%,
The method of preparing the composite sheet of Thallus Laminariae (Thallus Eckloniae) extract and Cordyceps militaris (L.) Link., comprises the following steps:
(
1) preparation of Thallus Laminariae (Thallus Eckloniae) extract: Thallus Laminariae (Thallus Eckloniae) weight in wet base 1000kg, without pulverizing or cutting into pieces, putting into sea water heats in the large-scale steamer of 85 degrees Celsius 1 minute, take out after Thallus Laminariae (Thallus Eckloniae), go with sea water is cold, in order to prevent that in Thallus Laminariae (Thallus Eckloniae), not overflowing of polysaccharide liquid stirred, add the neutral potassium salt that is equivalent to weight in wet base Thallus Laminariae (Thallus Eckloniae) 40%, pickle 24 hours, the raising of salinity in water, can cause that Thallus Laminariae (Thallus Eckloniae) cell wall acutely shrinks, secrete a large amount of humoral substances, centrifuge dewatering obtain 300 liters of liquid that contain Thallus Laminariae (Thallus Eckloniae) extract, then add water, alcohol precipitation obtain Thallus Laminariae (Thallus Eckloniae) extract
(2) in step (1), in the Thallus Laminariae (Thallus Eckloniae) extract of preparation, add Cordyceps militaris (L.) Link.,
(3) add additive, and be pressed into compound sugar-tablet.
Embodiment 2
A composite sheet for Thallus Laminariae (Thallus Eckloniae) extract and Cordyceps militaris (L.) Link., comprises the composition of following weight fraction: Thallus Laminariae (Thallus Eckloniae) extract 40%, Cordyceps militaris (L.) Link. 40%, and Concha Ostreae powder 10%, Agaricus blazei Murrill dry powder 10%,
The method of preparing the composite sheet of Thallus Laminariae (Thallus Eckloniae) extract and Cordyceps militaris (L.) Link., comprises the following steps:
1) preparation of Thallus Laminariae (Thallus Eckloniae) extract: Thallus Laminariae (Thallus Eckloniae) weight in wet base 1000kg, without pulverizing or cutting into pieces, putting into sea water heats in the large-scale steamer of 85 degrees Celsius 1 minute, take out after Thallus Laminariae (Thallus Eckloniae), go with sea water is cold, in order to prevent that in Thallus Laminariae (Thallus Eckloniae), not overflowing of polysaccharide liquid stirred, add the neutral potassium salt that is equivalent to weight in wet base Thallus Laminariae (Thallus Eckloniae) 40%, pickle 24 hours, the raising of salinity in water, can cause that Thallus Laminariae (Thallus Eckloniae) cell wall acutely shrinks, secrete a large amount of humoral substances, centrifuge dewatering obtain 300 liters of liquid that contain Thallus Laminariae (Thallus Eckloniae) extract, then add water, alcohol precipitation obtain Thallus Laminariae (Thallus Eckloniae) extract
(2) in step (1), in the Thallus Laminariae (Thallus Eckloniae) extract of preparation, add Cordyceps militaris (L.) Link.,
(3) add additive, and be pressed into compound sugar-tablet.
Embodiment 3 zooperies
As shown in Fig. 1-7, TK: the composite sheet that Thallus Laminariae (Thallus Eckloniae) extract, Cordyceps militaris (L.) Link. form.
Thallus Laminariae (Thallus Eckloniae) extract, pupa worm glycoconjugates grass can stimulating human islet cells line (RIN-5F) and Mice Islet Cells line MIN-6 excreting insulins.We sent out and can improve glycolated hemoglobin KK-Ay/Ta in rat blood afterwards, can be widely used in type 2 diabetes mellitus treatment.Select the rat of Spontaneous Diabetic (SDT); The obvious hyperglycemia of male SDT rat, polyuria, polydipsia, polyphagia, insulin level in blood and body weight all present downward trend gradually, and due to long-term hyperglycemia, SDT rat suffers from early diabetic nephropathy, diabetic peripheral neuropathy, diabetic retinopathy.
laboratory observation:
The foodstuff mixture of traditional standard, TK is in the concentration of 2%w/w, and since 100 week age to Oral Administration in Rats.Matched group gives common food does not have TK, and wild type SD rat is as Normal group.Survey weekly body weight, blood glucose, food intake dose and microdose urine protein/creatinine level, in serum insulin and blood, per fortnight of glycolated hemoglobin level measures once.In results in the end of the year, carry out nephridial tissue pathological examination.
Experiment conclusion
1.TK is the protection successful to glycolated hemoglobin, kidney in the anti-diabetic of SDT type ii diabetes rat model.The rat of 2.TK shows blood glucose and glycolated hemoglobin growth slowdown.3.SDT rat appetite is larger, and rear body weight increase in 15 weeks is very fast, and this shows that metabolism becomes worse.Than the not too not large variation of TK body weight, show to improve the metabolism of TK with common mouse.
The serum insulin of 4.SDT rat has fallen suddenly, reaches almost nil 18 week age and 20 weeks.5. before 18 weeks, the serum insulin of SDT and TK keeps normal, but starts at 20 weeks to decline.6. uroscopy is found, the diabetic nephropathy of SDT rat, 13 week age, belongs to early stage what test.And TK significantly suppresses nephropathy.
7.TK nephridial tissue pathology does not occur.
Claims (3)
1. a composite sheet for Thallus Laminariae (Thallus Eckloniae) extract and Cordyceps militaris (L.) Link., is characterized in that, comprises the composition of following weight fraction: Thallus Laminariae (Thallus Eckloniae) extract 10-45%, Cordyceps militaris (L.) Link. 10-45%, additive 5-30%.
2. the composite sheet of Thallus Laminariae (Thallus Eckloniae) extract according to claim 1 and Cordyceps militaris (L.) Link., is characterized in that, additive is one or more in artificial Radix Ginseng, Concha Ostreae powder, Agaricus blazei Murrill dry powder.
3. the method for the composite sheet of the Thallus Laminariae (Thallus Eckloniae) extract described in preparation claim 2 and Cordyceps militaris (L.) Link., is characterized in that, comprises the following steps:
(
1) preparation of Thallus Laminariae (Thallus Eckloniae) extract: Thallus Laminariae (Thallus Eckloniae) weight in wet base 1000kg, without pulverizing or cutting into pieces, putting into sea water heats in the large-scale steamer of 85 degrees Celsius 1 minute, take out after Thallus Laminariae (Thallus Eckloniae), go with sea water is cold, add the neutral potassium salt that is equivalent to weight in wet base Thallus Laminariae (Thallus Eckloniae) 40%, pickle 24 hours, centrifuge dewatering obtain 300 liters of liquid that contain Thallus Laminariae (Thallus Eckloniae) extract, then add water, alcohol precipitation obtain Thallus Laminariae (Thallus Eckloniae) extract;
(2) in step (1), in the Thallus Laminariae (Thallus Eckloniae) extract of preparation, add Cordyceps militaris (L.) Link.;
(3) add additive, and be pressed into compound sugar-tablet.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310677736.8A CN103860604B (en) | 2013-12-13 | 2013-12-13 | Compound tablet containing kelp extract and cordyceps militaris |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310677736.8A CN103860604B (en) | 2013-12-13 | 2013-12-13 | Compound tablet containing kelp extract and cordyceps militaris |
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| CN103860604A true CN103860604A (en) | 2014-06-18 |
| CN103860604B CN103860604B (en) | 2017-01-11 |
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| CN104083528A (en) * | 2014-07-20 | 2014-10-08 | 青岛昆布生物工程有限公司 | Brown seaweed and agaricus blazei murill compound tablet for improving human immunity and preparation method of compound tablet |
| CN107050066A (en) * | 2017-02-14 | 2017-08-18 | 厦门华言科技有限公司 | Astaxanthin kelp self-emulsifying soft capsule and its preparation method and application |
| CN107125753A (en) * | 2017-06-22 | 2017-09-05 | 烟台市芝罘区康华生物研究所 | A kind of golden cordyceps sinensis jelly fungi electuary |
| CN107136281A (en) * | 2017-06-09 | 2017-09-08 | 清华大学 | It is a kind of to be used to improve kelp cordyceps sinensis pressed candy of women renal function and preparation method thereof |
| CN107410642A (en) * | 2017-06-05 | 2017-12-01 | 清华大学 | It is a kind of to be used to improve kelp cordyceps sinensis pressed candy of male's renal function and preparation method thereof |
| CN110354150A (en) * | 2019-06-19 | 2019-10-22 | 青岛昆布生物工程有限公司 | A kind of anti-chemotherapy brown alga composite sheet of service hoisting leucocyte |
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| CN1623423A (en) * | 2003-12-03 | 2005-06-08 | 王福来 | Method of preparing sodium algin jelly skin directly using kelp |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104083528A (en) * | 2014-07-20 | 2014-10-08 | 青岛昆布生物工程有限公司 | Brown seaweed and agaricus blazei murill compound tablet for improving human immunity and preparation method of compound tablet |
| CN107050066A (en) * | 2017-02-14 | 2017-08-18 | 厦门华言科技有限公司 | Astaxanthin kelp self-emulsifying soft capsule and its preparation method and application |
| CN107410642A (en) * | 2017-06-05 | 2017-12-01 | 清华大学 | It is a kind of to be used to improve kelp cordyceps sinensis pressed candy of male's renal function and preparation method thereof |
| CN107136281A (en) * | 2017-06-09 | 2017-09-08 | 清华大学 | It is a kind of to be used to improve kelp cordyceps sinensis pressed candy of women renal function and preparation method thereof |
| CN107125753A (en) * | 2017-06-22 | 2017-09-05 | 烟台市芝罘区康华生物研究所 | A kind of golden cordyceps sinensis jelly fungi electuary |
| CN110354150A (en) * | 2019-06-19 | 2019-10-22 | 青岛昆布生物工程有限公司 | A kind of anti-chemotherapy brown alga composite sheet of service hoisting leucocyte |
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