CN103599405B - A kind of hypoglycemic medicine composition and preparation method thereof - Google Patents
A kind of hypoglycemic medicine composition and preparation method thereof Download PDFInfo
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- CN103599405B CN103599405B CN201310493295.6A CN201310493295A CN103599405B CN 103599405 B CN103599405 B CN 103599405B CN 201310493295 A CN201310493295 A CN 201310493295A CN 103599405 B CN103599405 B CN 103599405B
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Abstract
The invention discloses a kind of hypoglycemic medicine composition, comprise Radix Codonopsis 20-30 weight portion, Radix Puerariae 20-30 weight portion, Stigma Maydis 20-30 weight portion, Radix Dipsaci 5-15 weight portion, Rhizoma Alismatis 5-15 weight portion, careless Pi 5-15 weight portion, Radix Oenotherae erythrosepalae 5-15 weight portion, Fructus Leonuri 5-15 weight portion.Present invention also offers the preparation method of this hypoglycemic medicine composition.Hypoglycemic medicine composition therapeutic effect provided by the invention is good, toxic and side effects is little, cheap, preparation method is easy, is suitable for clinical practice.
Description
Technical field
The invention belongs to the field of Chinese medicines, be specifically related to a kind of pharmaceutical composition and preparation method thereof, particularly hypoglycemic pharmaceutical composition of one and preparation method thereof.
Background technology
Diabetes (diabetes) act on body by the various virulence factor of inherited genetic factors, immunologic function disorder, infected by microbes and toxin thereof, free radical toxin, Nervous and Mental Factors etc. to cause hypoinsulinism, insulin resistant (InsulinResistance, the a series of metabolism disorder syndrome such as sugar, protein, fat, water and eletrolytes caused such as IR), be main feature clinically with hyperglycemia, the performance such as polyuria, polydipsia, polyphagia can appear in model case, become thin, i.e. " three-many-one-little " symptom.Owing to living now, frequency is accelerated, and people is lived irregular, moves less in addition, thus cause the rising of blood sugar for human body and blood fat, lead diabetogenic sickness rate and increase.The usual clinical manifestation of hyperglycemia of human body is easy on the trigger, and have neurasthenia's phenomenon, dizzy headache, face is micro-red, and trick is ice-cold.Also be usually expressed as and can eat, usually thirsty, drink and just urinate, evening, sleep was unstable, and normal sense is tired in the daytime, loses weight, partially has a sweet tooth.
The treatment of current diabetes is mostly by blood sugar lowering Western medicine, not only expensive, and is mostly hormone medicine, curative effect is short, not obvious, to the heart, brain, liver, the equal toxic side effect of kidney, and diabetes patient's heart and brain kidney liver own has been subject to the infringement of high sugar, two poison have been added, and make the matter worse; Secondly these blood sugar lowering Western medicine stimulate islet secretion, that is can not drug withdrawal, must take everyday.As can be seen here, blood sugar lowering Western medicine is a double-edged sword, controls blood glucose on the one hand, on the other hand also at murder by poisoning life.
Medical research shows that the various saponin that contains in Chinese medicine and various flavone have good adjustment and reduce the effect of hyperlipidemia and blood glucose, but the current various medicine that can regulate and reduce hyperlipidemia and blood glucose, curative effect is undesirable.
Summary of the invention
Technical problem to be solved: in order to solve the defect that existing hypoglycemic drug therapeutic effect is poor, toxic and side effects is large, the invention provides a kind of hypoglycemic medicine composition and preparation method thereof.
Technical scheme: in order to solve the problems of the technologies described above, the invention provides a kind of hypoglycemic medicine composition, comprise Radix Codonopsis 20-30 weight portion, Radix Puerariae 20-30 weight portion, Stigma Maydis 20-30 weight portion, Radix Dipsaci 5-15 weight portion, Rhizoma Alismatis 5-15 weight portion, careless Pi 5-15 weight portion, Radix Oenotherae erythrosepalae 5-15 weight portion, Fructus Leonuri 5-15 weight portion.
Pharmaceutical composition provided by the invention, preferred Radix Codonopsis 25 weight portion, Radix Puerariae 25 weight portion, Stigma Maydis 25 weight portion, Radix Dipsaci 10 weight portion, Rhizoma Alismatis 10 weight portion, careless Pi 10 weight portion, Radix Oenotherae erythrosepalae 10 weight portion, Fructus Leonuri 10 weight portion.
Present invention also offers a kind of preparation method of hypoglycemic medicine composition, comprise the following steps:
(1) Radix Codonopsis 10-15 weight portion, Radix Puerariae 10-15 weight portion, Stigma Maydis 10-15 weight portion, Radix Dipsaci 10-15 weight portion, Rhizoma Alismatis 10-15 weight portion, careless Pi 10-15 weight portion, Radix Oenotherae erythrosepalae 10-15 weight portion, Fructus Leonuri 10-15 weight portion are mixed to get mixed material, add the ethanol water reflux, extract, 2-4 hour of 5-30 times of quality;
(2) elimination medicinal residues, leave standstill 12 to 24 hours, and filter, filtrate is concentrated into the clear paste that relative density is 1.12 to 1.16;
(3) clear paste adds 5-10 times of water gaging, leaves standstill 12 to 24 hours, and filter, filtrate is concentrated into dry, obtains said composition.
Wherein, in step (1), described ethanol water volume ratio is 7:3.
Wherein, in step (1), reflux temperature is 75-85 DEG C.
The quality of described ethanol water is 10-20 times of mixed material.
Beneficial effect: hypoglycemic medicine composition therapeutic effect provided by the invention is good, toxic and side effects is little, cheap, preparation method is easy, is suitable for clinical practice.
Detailed description of the invention
According to following embodiment, the present invention may be better understood.But those skilled in the art will readily understand, concrete material proportion, process conditions and result thereof described by embodiment only for illustration of the present invention, and should can not limit the present invention described in detail in claims yet.
Embodiment 1 hypoglycemic medicine composition 1.
Prescription: Radix Codonopsis 250g, Radix Puerariae 250g, Stigma Maydis 250g, Radix Dipsaci 100g, Rhizoma Alismatis 100g, careless Pi 100g, Radix Oenotherae erythrosepalae 100g, Fructus Leonuri 100g.
Preparation method: Radix Codonopsis 250g, Radix Puerariae 250g, Stigma Maydis 250g, Radix Dipsaci 100g, Rhizoma Alismatis 100g, careless Pi 100g, Radix Oenotherae erythrosepalae 100g, Fructus Leonuri 100g, obtain mixed material, adds 12.5kg ethanol water reflux, extract, 3 hours;
Elimination medicinal residues, leave standstill 12 to 24 hours, and filter, filtrate is concentrated into the clear paste that relative density is 1.12 to 1.16, obtains 400ml clear paste;
Clear paste adds 3200ml water, leaves standstill 12 to 24 hours, and filter, filtrate is concentrated into dry, obtains said composition.
Embodiment 2 hypoglycemic medicine composition 2 and preparation method thereof.
Prescription: Radix Codonopsis 200g, Radix Puerariae 200g, Stigma Maydis 300g, Radix Dipsaci 50g, Rhizoma Alismatis 50g, careless Pi 150g, Radix Oenotherae erythrosepalae 150g, Fructus Leonuri 150g.
Preparation method: Radix Codonopsis 200g, Radix Puerariae 200g, Stigma Maydis 300g, Radix Dipsaci 50g, Rhizoma Alismatis 50g, careless Pi 150g, Radix Oenotherae erythrosepalae 150g, Fructus Leonuri 150g are mixed, obtains mixed material, add 6.25kg ethanol water reflux, extract, 2 hours;
Elimination medicinal residues, leave standstill 12 to 24 hours, and filter, filtrate is concentrated into the clear paste that relative density is 1.12 to 1.16, obtains 120ml clear paste;
Clear paste adds 600ml water, leaves standstill 12 to 24 hours, and filter, filtrate is concentrated into dry, obtains said composition.
Embodiment 3 hypoglycemic medicine composition 3.
Prescription: Radix Codonopsis 300g, Radix Puerariae 300g, Stigma Maydis 300g, Radix Dipsaci 150g, Rhizoma Alismatis 150g, careless Pi 150g, Radix Oenotherae erythrosepalae 150g, Fructus Leonuri 150g.
Preparation method: by Radix Codonopsis 300g, Radix Puerariae 300g, Stigma Maydis 300g, Radix Dipsaci 150g, Rhizoma Alismatis 150g, careless Pi 150g, Radix Oenotherae erythrosepalae 150g, Fructus Leonuri 150g, obtain mixed material, add 25kg ethanol water reflux, extract, 4 hours;
Elimination medicinal residues, leave standstill 12 to 24 hours, and filter, filtrate is concentrated into the clear paste that relative density is 1.12 to 1.16, obtains 500ml clear paste;
Clear paste adds 5000ml water, leaves standstill 12 to 24 hours, and filter, filtrate is concentrated into dry, obtains said composition.
The evaluation of embodiment 4 hypoglycemic drug effect.
1 materials and methods
1.1 experiment material
1.1.1 reagent chain phleomycin (STZ), Gou Bai Sigma Co., USA; The pharmaceutical composition of the embodiment of the present invention 1, embodiment 2, embodiment 3.
1.1.2 laboratory animal SD rat 90, by Shanghai, western pul-Kai laboratory animal company limited provides, male and female dual-purpose, body weight 150g ~ 250g.
1.2 experimental technique
1.2.1 modeling method
Rat Fast, can't help water 12-16h, with the STZ solution (Fresh) that the sodium citrate buffer solution (cold preservation) of 0.1mol/L, PH4.2 is mixed with, 1 the property injection in abdominal cavity, detects blood glucose in modeling after 7 days, and it is model success that random blood sugar value is greater than 11.1mmol/L.
1.2.2 grouping and administration
Rat is by sex and body weight grouping, be divided into 5 groups at random, often organize 18, normal group, model group, embodiment 1 intervention group, embodiment 2 intervention group, embodiment 3 intervention group, gavage the pharmaceutical composition 42mg/kg of distilled water 10mL/kg, the embodiment of the present invention 1, embodiment 2, embodiment 3 respectively.Above-mentioned intervention group is all give pharmaceutical composition of the present invention on modeling rat basis.All animals administration every day 1 time, successive administration 3 weeks, after last administration, fasting 12h, adopts strong blood sugar monitoring instrument and test strips, surveys fasting blood sugar through tail venous blood sampling.
1.3 date processing
Adopt the process of SPSS16.0 statistical software.Test each index determining result to represent with Mean scholar SD.Between group, mean compares employing one factor analysis of variance and paired t-test, and P<0.05 is for there being statistical significance.
2 experimental results, in table 1
Table 1 embodiment of the present invention gained health product blood sugar decreasing effect
Note: compare with normal group,
*p<0.05; Compare with model group,
*p<0.05.
By upper table gained, compared with normal group, the blood sugar level of model group significantly raises, and has significant difference, shows hyperglycemia model modeling success; Compare model group, the rat blood sugar level of embodiment 1 intervention group, embodiment 2 intervention group, embodiment 3 intervention group all significantly reduces, and has significant difference.Show that gained pharmaceutical composition of the present invention has and significantly fall hypoglycemic function.
The above is only the preferred embodiment of the present invention, is noted that for those skilled in the art, in scope disclosed by the invention, carries out some improvement and modification, also should be considered as protection scope of the present invention.
Claims (2)
1. a hypoglycemic medicine composition, is characterized in that: be made up of Radix Codonopsis 20-30 weight portion, Radix Puerariae 20-30 weight portion, Stigma Maydis 20-30 weight portion, Radix Dipsaci 5-15 weight portion, Rhizoma Alismatis 5-15 weight portion, careless Pi 5-15 weight portion, Radix Oenotherae erythrosepalae 5-15 weight portion, Fructus Leonuri 5-15 weight portion.
2. a kind of hypoglycemic medicine composition according to claim 1, is characterized in that: be made up of Radix Codonopsis 25 weight portion, Radix Puerariae 25 weight portion, Stigma Maydis 25 weight portion, Radix Dipsaci 10 weight portion, Rhizoma Alismatis 10 weight portion, careless Pi 10 weight portion, Radix Oenotherae erythrosepalae 10 weight portion, Fructus Leonuri 10 weight portion.
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101322731A (en) * | 2007-06-11 | 2008-12-17 | 刘延华 | Capsule for protecting eye and lowering blood sugar |
| CN103251827A (en) * | 2013-04-29 | 2013-08-21 | 翁炳焕 | Traditional Chinese medicine composition for treating diabetes mellitus and preparation method thereof |
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2013
- 2013-10-18 CN CN201310493295.6A patent/CN103599405B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101322731A (en) * | 2007-06-11 | 2008-12-17 | 刘延华 | Capsule for protecting eye and lowering blood sugar |
| CN103251827A (en) * | 2013-04-29 | 2013-08-21 | 翁炳焕 | Traditional Chinese medicine composition for treating diabetes mellitus and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 糖尿病的中医病机与治法;张燕，等;《中医药临床杂志》;20080831;第20卷(第4期);第347-348页 * |
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Address after: 325200 Wenzhou City, Ruian City, fairy street, the village of the first Village No. 115 Applicant after: Bian Jialin Address before: 212100, No. 4, No. 54, Henderson Pacific Business Center, Dantu New District, Jiangsu, Zhenjiang Applicant before: Bian Jialin |
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Effective date of registration: 20220407 Address after: 016100 No. 069, Albas sumuhu and tolgaigacha, otok banner, Ordos City, Inner Mongolia Autonomous Region Patentee after: Anan Yutaka Address before: 325200 No. 115 Tong Tou village, Xian Jiang Street, Ruian, Wenzhou, Zhejiang Patentee before: Bian Jialin |
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