CN105412222A - Preparation method of sweet tea and cyclocarya paliurus composite original tea - Google Patents
Preparation method of sweet tea and cyclocarya paliurus composite original tea Download PDFInfo
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
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Abstract
The invention discloses a preparation method of sweet tea and cyclocarya paliurus composite original tea. The preparation method includes the steps that the sweet tea and the cyclocarya paliurus are mixed according to weight ratio of (1-2):(1-10), 60-75v% of ethyl alcohol is added, extraction is conducted under the ultrasonic condition, whitewash is added to a extracting solution to adjust the pH to be 7.6-7.8, centrifugation is conducted, liquid supernatant is filtered out, sediment is picked to be frozen and dried, and the composite original tea is obtained. The composite original tea prepared through the method has a synergistic effect on the aspect of reduction of blood sugar of diabetes and has a certain protective function of improving diabetic complication abnormal fat metabolism and kidney injury.
Description
Technical field
The present invention relates to the preparation method of the former tea of a kind of compound, be specifically related to the preparation method of the former tea of compound of a kind of Folium hydrangeae strigosae and Cyclocarya paliurus Iljinskaja.
Background technology
Diabetes are chronic lifelong participation diseases, and along with the raising of people's living standard, its sickness rate is in the trend risen year by year.In order to control blood glucose, long-term limit sugar diet and Drug therapy have also had a strong impact on the quality of life of patient.Folium hydrangeae strigosae (RubusSuavissmusSLee) is the leaf of the distinctive natural sweet taste plant in Guangxi, is also Gao Tian best in the world, low grade fever, safety non-toxic and have the sweet-tasting plant of health care.In Folium hydrangeae strigosae about containing the bioflavonoids of 4.1%, the sweet tea tannins of 18.04% and 5% glycosides (Rubusoside).Research finds that glycosides can reduce normal mouse blood sugar level, has obvious inhibitory action to mice glyconeogenesis.By the hyperglycemic rat gavage that sweet tea extract brings out streptozotocin, the indexs such as blood glucose, fructosamine, insulin and SOD are surveyed after 3 weeks, find that sweet tea extract can reduce rat blood sugar significantly, strengthen its oxidation resistance, the secretion of insulin can be stimulated to reduce blood glucose simultaneously.
Although prior art discloses Folium hydrangeae strigosae can be used for the treatment of diabetes separately, the target spot of its effect limits to relatively, effectively cannot prevent and treat the generation of diabetic complication.
Summary of the invention
The technical problem to be solved in the present invention is to provide the preparation method of the former tea of compound of a kind of Folium hydrangeae strigosae and Cyclocarya paliurus Iljinskaja; the former tea of this compound not only has synergism at diabetes blood sugar-reduction formula mask, and to improving diabetic complication Anomalous lipid metablism and kidney injury has certain protective effect.
Technical scheme provided by the invention is the preparation method of the former tea of compound of Folium hydrangeae strigosae and Cyclocarya paliurus Iljinskaja, Folium hydrangeae strigosae and Cyclocarya paliurus Iljinskaja are mixed by 1 ~ 2:1 ~ 10 weight ratio, add the ethanol of 60 ~ 75v%, extract under Ultrasonic Conditions, add lime water toward extracting solution and regulate pH to 7.6 ~ 7.8, centrifugal, elimination supernatant, taking precipitate lyophilization, is the former tea of compound.
The Cyclocarya paliurus Iljinskaja dry leaf that to be Cyclocarya paliurus Iljinskaja be (Latin literary fame: Cyclocaryapaliurus.), has certain hypoglycemic activity.
Step 1) in, be the composition such as the polyphenol in the ethanol extraction Folium hydrangeae strigosae of 60 ~ 75% and the polysaccharide in Cyclocarya paliurus Iljinskaja by volumetric concentration.Lime water regulates pH to 7.6 ~ 7.8, can by the polyphenols complex-precipitation in extracting solution.There is multiple ortho positions phenolic hydroxyl group in sweet tea tannins molecule, can be used as multidentate ligand and Ca
2+complexation, forms the chelate of ring-type and produces precipitation, and when pH value is 7.6 ~ 7.8, sweet tea tannins is with the negative oxygen ion of an ionic state and a phenolic hydroxyl group and Ca
2+complexation, or with the negative oxygen ion of two ionic state and Ca
2+complexation, formation be an aglucon complex compound sediment.Meanwhile, under this pH value condition, sweet tea tannins also also form an aglucon complex compound sediment with Cyclocarya paliurus Iljinskaja polysaccharide molecule.
Ultrasonic Conditions 1 ~ 3 time, each 1 ~ 2h; Ultrasonic Conditions is: temperature 40 ~ 50 DEG C, frequency are 250 ~ 400Hz.Preferred ultrasonic frequency is 300 ~ 400Hz.During each extraction, the addition of ethanol is 4 ~ 10 times of Folium hydrangeae strigosae and Cyclocarya paliurus Iljinskaja gross weight.
The preferred weight ratio of Folium hydrangeae strigosae and Cyclocarya paliurus Iljinskaja is 1:1.
Former tea of the present invention conveniently technique can be deployed into compound tea, for diabetes patients.
Compared with prior art, the present invention is by sweet tea tannins molecule and Ca
2+complexation generates an aglucon complex compound sediment; and sweet tea tannins and the complexation of Cyclocarya paliurus Iljinskaja polysaccharide molecule are formed an aglucon complex compound sediment; the mixture of an above-mentioned aglucon complex can play collaborative hypoglycemic effect, and to improving diabetic complication Anomalous lipid metablism and kidney injury has certain protective effect.Empirical tests, the hypoglycemic effect of this mixed complex is far superior to the conventional extract of Folium hydrangeae strigosae and Cyclocarya paliurus Iljinskaja.
Detailed description of the invention
Embodiment 1
Sweet tea and leaf of Cyclocarya paliurus Iljinskaja are pressed 1:1 weight ratio co-grinding, add the ethanol of 60v%, the addition of ethanol is 4 times of Folium hydrangeae strigosae and Cyclocarya paliurus Iljinskaja gross weight, 1h is extracted under being the Ultrasonic Conditions of 250Hz in temperature 40 DEG C, frequency, in extracting solution, add lime water regulate pH to 7.6, centrifugal, elimination supernatant, taking precipitate lyophilization, is the former tea of compound.
Reference examples 1
Pulverized by leaf of Cyclocarya paliurus Iljinskaja, add the ethanol of 60v%, 4 times of the addition Cyclocarya paliurus Iljinskaja weight of ethanol, extract 1h in temperature 40 DEG C, frequency under being the Ultrasonic Conditions of 250Hz, by extracting solution concentrating under reduced pressure recycling design, lyophilization, is the former tea of Cyclocarya paliurus Iljinskaja.
Reference examples 2
Sweet tea is pulverized, adds the water of Folium hydrangeae strigosae weight 4 times, extract 1h in temperature 40 DEG C, frequency under being the Ultrasonic Conditions of 250Hz, extracting solution is concentrated into extractum, lyophilization, be the former tea of Folium hydrangeae strigosae.
Embodiment 2
Sweet tea and leaf of Cyclocarya paliurus Iljinskaja are pressed 1:10 weight ratio co-grinding, add the ethanol of 75v%, the addition of ethanol is 10 times of Folium hydrangeae strigosae and Cyclocarya paliurus Iljinskaja gross weight, extracts 3 times, each 2h under temperature 50 C, frequency are the Ultrasonic Conditions of 400Hz, merge extractive liquid, in extracting solution, add lime water regulate pH to 7.8, centrifugal, elimination supernatant, taking precipitate lyophilization, is the former tea of compound.
Embodiment 3
Sweet tea and leaf of Cyclocarya paliurus Iljinskaja are pressed 2:1 weight ratio co-grinding, add the ethanol of 70v%, the addition of ethanol is 6 times of Folium hydrangeae strigosae and Cyclocarya paliurus Iljinskaja gross weight, extracts 2 times, each 1.5h under temperature 45 C, frequency are the Ultrasonic Conditions of 300Hz, merge extractive liquid, in extracting solution, add lime water regulate pH to 7.8, centrifugal, elimination supernatant, taking precipitate lyophilization, is the former tea of compound.
Embodiment 4
Sweet tea and leaf of Cyclocarya paliurus Iljinskaja are pressed 2:10 weight ratio co-grinding, add the ethanol of 60v%, the addition of ethanol is 10 times of Folium hydrangeae strigosae and Cyclocarya paliurus Iljinskaja gross weight, extract 2h, merge extractive liquid, in temperature 40 DEG C, frequency under being the Ultrasonic Conditions of 400Hz, in extracting solution, add lime water regulate pH to 7.7, centrifugal, elimination supernatant, taking precipitate lyophilization, is the former tea of compound.
Experimental example
1, the foundation of diabetic mouse model
By the healthy kunming mice 100 of body weight at 18 ~ 22g, male and female half and half, carry out randomly drawing 20 after adaptability feeds one week for blank group, except blank group mice feeds chow diet, all the other 80 mices all feed high lipid food, feed equal overnight fasting after 4 weeks, take every Mouse Weight, and according to every Mouse Weight, give abdominal cavity, 80 mice lower-lefts disposable injection streptozotocin (STZ) the citric acid-sodium citrate injection 200mg/kg except blank group, blank group only injects the citric acid-sodium citrate buffer of equal volume.Inject after STZ3 days, fasting 12h, tail venous blood sampling surveys its fasting glucose, and with fasting glucose >=11.1mmol/L is the successful standard of experimental NIDDM Establishment of mouse model.
High lipid food formula: normal feedstuff 78.8%, yolk powder 10%, Adeps Sus domestica 10%, cholesterol 1%, sodium cholate 0.2%.
The mice be successfully established by model is divided into model control group, experimental group, matched group 1, matched group 2 at random, often organizes 20.Model control group continues to give high lipid food, uses distilled water gavage.All the other each group while giving high lipid food, according to dosage 350mg/kg gives the former tea gavage of embodiment 1, reference examples 1 and reference examples 2 respectively.Every morning 9 gavages, every day 1 time, continuous gavage 12 weeks, fasting 12h after administration in 12nd week, to after every mice according to dosage 2g/kg glucose gavage at the carbohydrate tolerance that its corresponding time tail venous blood sampling measures, afterwards, weigh the body weight of every mice, take to pluck eyeball method and get blood 1.5ml, upper serum is drawn after 3500r/min is centrifugal 10 minutes, pick the liver,spleen,kidney of mice, pancreas, clean with normal saline and weigh after blotting with clean filter paper to be placed on immediately in-80 DEG C of refrigerators together with serum and preserve, for subsequent use.
2, STZ is caused to the experiment of diabetic mice carbohydrate tolerance
Gavage process is after 12 weeks, the equal fasting 8h of each group mice, take mouse tail vein to get blood glucose value that blood records as the blood glucose value of 0h, then according to dosage 2g/kg gavage glucose solution, then after gavage 0.5,1,1.5,2h tail venous blood sampling measures blood glucose value.Observe the change of each group of blood sugar concentration on each time point.
3, the mensuration of indices
After diabetic mouse model is successfully established, every day observes the ordinary circumstance of mice, as chroma of hair, motion frequency, feed inflow, body weight etc.Weigh the body weight of each group of mice at gastric infusion in 12 weeks on every Fridays morning, and after fasting 12h, adopt tail venous blood sampling to measure the fasting blood sugar of each group of mice.
3.1 blood preparation indexs
Go eyeball to get blood, the centrifugal 10min of 3500r/min, separation of serum, measure blood glucose (GLU), T-CHOL (TC), triglyceride (TG), serum creatinine (SCr) with full automatic biochemical apparatus; Glycolated hemoglobin (GHbA1c), biological transforming factor β is measured by microplate reader
1(TGF-β
1).
3.2 urine specimen indexs
Experiment terminates the previous day collects 24h urine, gets 4ml after metering, and the centrifugal 10min of 3000r/min removes sediment, gets 2ml and measures 24h urine micro protein (mALB) and urine creatine (UCr).
4, experimental result:
The former tea of 4.1 compound causes the impact of diabetic mice fasting glucose in table 1 to STZ:
The former tea of table 1 compound on STZ cause diabetic mice fasting glucose impact (
n=20)
Note: each group compares with blank group, * p < 0.05, * * p < 0.01; Each group is compared with model control group, △ p < 0.05, △ △ p < 0.01.
The former tea of 4.2 compound causes the impact of diabetic mice carbohydrate tolerance in table 2 to STZ:
The former tea of table 2 compound causes the impact of diabetic mice carbohydrate tolerance on STZ
From table 1 and table 2, the former tea of experimental group has obvious hypoglycemic activity, improves its carbohydrate tolerance, effectively have adjusted the carbohydrate metabolism in diabetic mice.
The former tea of 4.3 compound on STZ cause diabetic mice TC the impact of TG in table 3:
The former tea of table 3 compound on STZ cause diabetic mice TC TG impact (
n=20)
| Group | TC(mmol/l) | TG(mmol/l) |
| Blank group | 3.00±0.61△ | 1.15±0.33△ |
| Model control group | 4.72±3.22 | 1.36±0.72 |
| Experimental group | 3.70±1.43△ | 1.16±0.53△ |
| Matched group 1 | 4.29±1.37△△ | 1.22±0.65△ |
| Matched group 2 | 4.18±1.73△ | 1.24±0.85△ |
Note: administration is respectively organized after 12 weeks and compared with model control group, △ p < 0.05, △ △ p < 0.01.
As shown in Table 3, the former tea of compound of experimental group is by reducing cholesterol TC too high in diabetic mice, triacylglycerol TG, the ability of enhancing body lipid metabolism, and successful is better than matched group.
The former tea of 4.4 compound causes diabetic mice TGF-β to STZ
1, mALB, GHbA1c impact in table 4:
The former tea of table 4 compound causes diabetic mice TGF-β to STZ
1, mALB, GHbA1c impact (
n=20)
| Group | TGF-β 1(pg/ml) | mALB(μg/ml) | GHbA1c(ng/ml) |
| Blank group | 6.67±1.21△△ | 1.46±1.02△ | 4.77±1.09△ |
| Model control group | 17.11±1.30 | 19.91±3.61 | 13.77±1.02 |
| Experimental group | 7.28±1.04△ | 7.60±2.70△ | 5.65±1.80△△ |
| Matched group 1 | 10.04±1.23△△ | 11.60±2.15△△ | 7.89±0.88△ |
| Matched group 2 | 10.91±1.06△ | 10.60±2.70△ | 7.65±1.80△△ |
Note: administration is respectively organized after 12 weeks and compared with model control group, △ p < 0.05, △ △ p < 0.01.
As shown in Table 5, biological transforming factor β 1 is the important factor causing diabetic mice kidney injury, and the former tea of compound of experimental group can reduce the content of biological transforming factor β 1 in diabetic mice significantly, and effect is better than matched group.Show that the kidney of experimental group to diabetic mice has protective effect, and certain preventive effect is played to the generation of diabetic nephropathy and development.
The former tea of compound of experimental group can obviously reduce glycated hemoglobin levels in Mice Body, alleviate because glycated hemoglobin levels raises the histanoxia caused to a great extent, alleviate glycated hemoglobin levels raise cause especially occur in the abundant position microangiopathies of kidney tip blood capillary, and then alleviate and cause histiocyte hypoxic-ischemic and tissue injury thus, and then the content of microdose urine protein also significantly reduces.The former tea of compound of experimental group significantly can reduce the content of microdose urine protein and glycolated hemoglobin in diabetic mice, have certain effect, and successful is better than matched group to diabetes and nephropathy preventing.
The former tea of 5.5 compound causes the impact of diabetic mice serum creatinine (SCr) and urine creatine (UCr) in table 5 to STZ:
The former tea of table 5 compound on STZ cause diabetic mice serum creatinine (SCr) and urine creatine (UCr) impact (
n=20)
| Group | SCr(μmol/l) | UCr(μmol/l) |
| Blank group | 9.43±1.41△△ | 425.77±1.23△ |
| Model control group | 16.91±1.02* | 103.32±1.04** |
| Experimental group | 9.61±1.70**△△ | 221.78±1.20*△ |
| Matched group 1 | 10.60±1.15*△ | 161.89±0.98*△△ |
| Matched group 2 | 10.73±1.64**△△ | 158.65±1.36**△△ |
Note: administration is respectively organized after 12 weeks and compared with blank group, * p < 0.05, * * p < 0.01; Each group is compared with model control group, △ p < 0.05, △ △ p < 0.01.
As shown in Table 5, serum creatinine and urine creatine are all the indexs of reflection kidney injury degree.The former tea of experimental group compound can reduce the content of serum creatinine in diabetic mice significantly; and the content of urine creatine in diabetic mice can be improved significantly; concentration both the former tea of the former tea of illustrative experiment group compound can effectively regulate in diabetic mice; thus reach the effect of protection kidney, and successful is better than matched group.
From table 1 ~ table 5, the former tea of compound of experimental group can by reducing cholesterol too high in diabetic mice, triacylglycerol, the ability of enhancing body lipid metabolism, blood sugar level in remarkable reduction diabetic mice, improve its carbohydrate tolerance, diabetic mice blood can also be improved simultaneously, the content of the urine creatine in urine, reduce diabetic mice blood, serum creatinine in urine, transforming growth factor-beta 1, microdose urine protein, effect of saccharification hemoglobin content, alleviate the kidney injury of diabetic nephropathy mice, to the damage of the mouse kidney that prevents diabetes, there is protective effect.
Claims (5)
1. the preparation method of the former tea of the compound of Folium hydrangeae strigosae and Cyclocarya paliurus Iljinskaja, it is characterized in that: Folium hydrangeae strigosae and Cyclocarya paliurus Iljinskaja are mixed by 1 ~ 2:1 ~ 10 weight ratio, add the ethanol of 60 ~ 75v%, extract under Ultrasonic Conditions, add lime water toward extracting solution and regulate pH to 7.6 ~ 7.8, centrifugal, elimination supernatant, taking precipitate lyophilization, is the former tea of compound.
2. the preparation method of the former tea of the compound of Folium hydrangeae strigosae according to claim 1 and Cyclocarya paliurus Iljinskaja, is characterized in that: Ultrasonic Conditions 1 ~ 3 time, each 1 ~ 2h; Described Ultrasonic Conditions is: temperature 40 ~ 50 DEG C, frequency are 250 ~ 400Hz.
3. the preparation method of the former tea of the compound of Folium hydrangeae strigosae according to claim 2 and Cyclocarya paliurus Iljinskaja, is characterized in that: described ultrasonic frequency is 300 ~ 400Hz.
4. the preparation method of the Folium hydrangeae strigosae according to any one of claims 1 to 3 and the former tea of the compound of Cyclocarya paliurus Iljinskaja, is characterized in that: the addition of ethanol is 4 ~ 10 times of Folium hydrangeae strigosae and Cyclocarya paliurus Iljinskaja gross weight.
5. the preparation method of the Folium hydrangeae strigosae according to any one of claims 1 to 3 and the former tea of the compound of Cyclocarya paliurus Iljinskaja, is characterized in that: the weight ratio of Folium hydrangeae strigosae and Cyclocarya paliurus Iljinskaja is 1:1.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108686053A (en) * | 2018-07-02 | 2018-10-23 | 广西壮族自治区药用植物园 | Compound blood pressure reducing instant tea and preparation method thereof |
| CN108853184A (en) * | 2018-08-31 | 2018-11-23 | 吉首大学 | A kind of blue or green money willow and Pasania cuspidata extract combination |
| CN114916597A (en) * | 2022-05-10 | 2022-08-19 | 湖南德康茶业科技有限公司 | Tea therapy composition for treating type 2 diabetes |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101669636A (en) * | 2009-09-23 | 2010-03-17 | 上海应用技术学院 | Chrysanthemum sweet tea chewable tablet and preparation method thereof |
| CN104042679A (en) * | 2014-07-08 | 2014-09-17 | 江平凡 | Hypoglycemic product containing cyclocarya paliurus |
-
2015
- 2015-12-22 CN CN201510974279.8A patent/CN105412222A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101669636A (en) * | 2009-09-23 | 2010-03-17 | 上海应用技术学院 | Chrysanthemum sweet tea chewable tablet and preparation method thereof |
| CN104042679A (en) * | 2014-07-08 | 2014-09-17 | 江平凡 | Hypoglycemic product containing cyclocarya paliurus |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108686053A (en) * | 2018-07-02 | 2018-10-23 | 广西壮族自治区药用植物园 | Compound blood pressure reducing instant tea and preparation method thereof |
| CN108853184A (en) * | 2018-08-31 | 2018-11-23 | 吉首大学 | A kind of blue or green money willow and Pasania cuspidata extract combination |
| CN108853184B (en) * | 2018-08-31 | 2021-04-13 | 吉首大学 | Cyclocarya paliurus and lithocarpus polystachyus rehd extract composition |
| CN114916597A (en) * | 2022-05-10 | 2022-08-19 | 湖南德康茶业科技有限公司 | Tea therapy composition for treating type 2 diabetes |
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