CN103349711B - Anti-aging combination with resveratrol and preparation method thereof - Google Patents
Anti-aging combination with resveratrol and preparation method thereof Download PDFInfo
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- CN103349711B CN103349711B CN201310324955.8A CN201310324955A CN103349711B CN 103349711 B CN103349711 B CN 103349711B CN 201310324955 A CN201310324955 A CN 201310324955A CN 103349711 B CN103349711 B CN 103349711B
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- resveratrol
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- acanthopanacis senticosi
- fructus lycii
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Abstract
The invention discloses an anti-aging combination with resveratrol and a preparation method thereof. The anti-aging combination with resveratrol is prepared with the following components by weight: 50 to 200 parts of resveratrol, 40 to 150 parts of acanthopanax senticosus extract, and 40 to 150 parts of wolfberry extract. The anti-aging combination with resveratrol prepared by the invention overcomes the defect that the action time of resveratrol in vivo is short when resveratrol is used alone, the addition of acanthopanax senticosus extractand wolfberry extract gives full play to synergistic effect between groups, the composition is good in stability and long in action time, the curative effect is improved, and the combination is provided with the functions of nourishing the kidney, strengthening the essence and boosting immunity, so as to delay senescence; the composition is safe and has no side effect.
Description
Technical field
The invention belongs to the field of Chinese medicines, be specifically related to a kind of anti-apolexis composition that contains resveratrol and preparation method thereof.
Background technology
Along with world population is stepped into " senescence epoch ", the problem that aging causes more and more receives publicity.Just current progress, aging is the inexorable law in any life process, it is regulation biology independent of man's will, stoping aging is impossible realize, but delaying senility speed is slowly carried out aging, allowing life-span of people reach the maximum life span that nature gives can reach completely, along with the appearance of aging society, to human society, a series of challenge is proposed, so discussion Aging mechanism and research on anti-senescence have become the key subjects of medical circle, biological educational circles.Natural plant composition has accumulated valuable theory and practice experience in health preserving aspect anti-aging, and has its unique advantage.The decline of body's immunity is to cause old and feeble and dead major reason.The causes of senescence of suffering from a deficiency of the kidney is paid attention to by ancient Chinese medicine doctor, also by modern pharmacological research is confirmed, in traditional Chinese medical science causes of senescence, occupies critical role.Kidney storing essence, is the congenital foundation, Source of life, taking kidney as presiding over, maintain all physiological functions of human body, make its unify balance and can self-regulated from normal activity quietly.Suffering from a deficiency of the kidney that causing declines is the yang-energy of kidney unit and the vital essence of kidney Tibetan loss, empty few, biochemical passive many old and feeble morbid state and the aging course causing of the five internal organs qi-blood-body fluid.
Meanwhile, along with going deep into of research, from microscopic fields, it is found that, the injury of peroxide and radical pair health is the most serious and the most general, and it is universally acknowledged healthy with beautiful main, the most extensive killer of injury, it is omnipresent, without not doing harm to.Thereby peroxide and free radical can destroy the genetic code of human body causes gene mutation to bring out cancer, tumor, seizes every year nearly ten million people's life; It is oxidized blood vessel, causes atherosclerosis to cause various cardiovascular and cerebrovascular diseases; It encroaches on human body viscera, accelerates cell ageing, accelerates body decline; It injures skin, and injury appearance, is the maximum old enemy who affects women's beauty.We know that strong ultra-vioket radiation is serious to skin damage, and its reason is because strong ultraviolet radiation can produce a large amount of free radicals, cause due to skin damage.Due to seriousness and the universality of the injury of free radical and peroxide, and environmental pollution is now serious etc., factor causes peroxide and free radical to spread unchecked.Therefore, antioxidation is very urgent with removing free radical.
Resveratrol is the Natural antioxidant being present in plant, be mainly derived from the plants such as Fructus Vitis viniferae, Rhizoma Polygoni Cuspidati, Semen arachidis hypogaeae, Fructus Mori, mainly generate by removing or suppressing free radical, suppress lipid peroxidation, regulate the mechanism performance antioxidations such as antioxidation related enzyme activity.Have the effect of stronger life lengthening, one group of scientist of Italian Piza finds by research, and the resveratrol containing in Fructus Vitis viniferae can help fish to lengthen the life.Accept in more than 100 fish of experiment, fed 30 every days a small amount of resveratrol, it is appropriate that 60 quilts are fed, and 20 quilts are fed with very large component, and what effect the 1st group of fish does not see as a result, the life of the 2nd group of fish 27%, the 3 group of fish life 50%.This is that scientist finds that resveratrol also has the effect of life lengthening to vertebrates for the first time.
Radix Et Caulis Acanthopanacis Senticosi is recorded in " practical Chinese medicine one book of taking a tonic or nourishing food to build up one's health ", belongs to Qi-tonifying drug, has effect that tonify deficiency is helped the weak, and can prevent or treat the disease having a delicate constitution, strengthening by means of tonics, life lengthening.The extract of Radix Acanthopanacis Senticosi root and glycoside all have antifatigue effect.The effect of glycoside phase extract is strong, is strong compared with Radix Ginseng extract and panaquilon.Lumbar injection Radix Et Caulis Acanthopanacis Senticosi alcohol extractum aqueous solution 20g/kg, on average extends mice swimming time 1/4.Caulis Et Caulis Acanthopanacis Senticosi severe edema due to hypofunction of the spleen extract 500mg/kg and syringaresinol-bis--o-B-D-glycoside 50mg/kg thereof all can significant prolongation rat load swimming times.
Fructus Lycii extract extracts from the mature fruit of dicotyledon medicine matrimony vine of solanaceae plant or lycium barbarum.Fructus Lycii is strengthening the body resistance, spermatogenesis is mended the good medicine of marrow, enriching yin and nourishing kidney, benefiting vital QI for tranquillizing, building body, slow down aging, be exactly that strengthening by means of tonics is supported the top grade of people since ancient times, effectively strengthen various functions, can improve brain function and the function to free radical resisting, there is the effect of obvious slow down aging.
Resveratrol is to be used for slow down aging by free radical resisting, antioxidative, although resveratrol has very strong anti-aging effects, because its structural stability is poor, and in blood the holdup time shorter, therefore its separately application be restricted.
Summary of the invention
The object of the invention is to overcome the deficiencies in the prior art, a kind of anti-apolexis composition that contains resveratrol is provided.
Second object of the present invention is to provide a kind of preparation method of the anti-apolexis composition that contains resveratrol.
An anti-apolexis composition that contains resveratrol, comprises following component by weight: resveratrol 50-200 part; Radix Et Caulis Acanthopanacis Senticosi extract 40-150 part; Fructus Lycii extract 40-150 part.
Preferred: resveratrol is 80-180 part; Radix Et Caulis Acanthopanacis Senticosi extract is 60-120 part; Fructus Lycii extract is 60-120 part.
A preparation method for the anti-apolexis composition that contains resveratrol, comprises the steps:
(1) take by weight: resveratrol 50-200 part; Radix Et Caulis Acanthopanacis Senticosi extract 40-150 part; Fructus Lycii extract 40-150 part;
(2) mix homogeneously, adds the acceptable adjuvant of pharmacy, makes capsule, granule or tablet.
Preferred: resveratrol is 80-180 part; Radix Et Caulis Acanthopanacis Senticosi extract is 60-120 part; Fructus Lycii extract is 60-120 part.
Advantage of the present invention:
When the present invention has overcome independent use resveratrol, in vivo action time short shortcoming, Radix Et Caulis Acanthopanacis Senticosi extract and Fructus Lycii extract are added, give full play to the synergism between component, the good stability of compositions, extend action time, improved curative effect, there is effect and then the slow down aging of the kidney invigorating and essence nourishing, enhancing immunity, and safety is without any side effects.
Detailed description of the invention
Raw material of the present invention:
Resveratrol (content 90%-98%), Radix Et Caulis Acanthopanacis Senticosi extract (Syringin, E content are greater than 0.3%), Fructus Lycii extract (crude polysaccharides content 10%-50%)
Resveratrol, Radix Et Caulis Acanthopanacis Senticosi extract and Fructus Lycii extract are purchased from Jianfeng Natural Product R&D Development Co., Ltd., Tianjin.
Disclosing of the source of above-mentioned raw materials, only in order to enable those skilled in the art to understand better the present invention, but the present invention is not imposed any restrictions, the above-mentioned raw materials that meets other source of resveratrol, Radix Et Caulis Acanthopanacis Senticosi extract and Fructus Lycii extract content requirement may be used to the present invention.
Resveratrol in each embodiment and pharmacodynamic experiment (content 90%), Radix Et Caulis Acanthopanacis Senticosi extract (Syringin, E content 0.4%), Fructus Lycii extract (crude polysaccharides content 10%)
Embodiment 1
A preparation method for the anti-apolexis composition that contains resveratrol, comprises the steps:
(1) take: resveratrol 50g; Radix Et Caulis Acanthopanacis Senticosi extract 40g; Fructus Lycii extract 40g;
(2) mix homogeneously, adds lactose 100g, dextrin 180g, and magnesium stearate 20g, the ethanol water that volumetric concentration is 60% is granule processed in right amount, is pressed into 1000, tablet.
Embodiment 2
A preparation method for the anti-apolexis composition that contains resveratrol, comprises the steps:
(1) take: resveratrol 80g; Radix Et Caulis Acanthopanacis Senticosi extract 60g; Fructus Lycii extract 60g;
(2) mix homogeneously, adds starch 280g, and magnesium stearate 20g, mixes, and makes 1000 of capsules.
Embodiment 3
A preparation method for the anti-apolexis composition that contains resveratrol, comprises the steps:
(1) take: resveratrol 120g; Radix Et Caulis Acanthopanacis Senticosi extract 80g; Fructus Lycii extract 80g;
(2) mix homogeneously, adds starch 100g, dextrin 180g, and magnesium stearate 20g, mixes, and the ethanol water that is 60% by volumetric concentration is granule processed in right amount.
Embodiment 4
A preparation method for the anti-apolexis composition that contains resveratrol, comprises the steps:
(1) take: resveratrol 140g; Radix Et Caulis Acanthopanacis Senticosi extract 100g; Fructus Lycii extract 100g;
(2) mix homogeneously, adds lactose 100g, dextrin 170g, and magnesium stearate 30g, mixes, the ethanol water granulation agent that is 60% by volumetric concentration.
Embodiment 5
A preparation method for the anti-apolexis composition that contains resveratrol, comprises the steps:
(1) take: resveratrol 180g; Radix Et Caulis Acanthopanacis Senticosi extract 120g; Fructus Lycii extract 120g;
(2) mix homogeneously, adds lactose 120g, dextrin 150g, and magnesium stearate 30g, mixes, the ethanol water granulation agent that is 60% by volumetric concentration
Embodiment 6
A preparation method for the anti-apolexis composition that contains resveratrol, comprises the steps:
(1) take: resveratrol 200g; Radix Et Caulis Acanthopanacis Senticosi extract 150g; Fructus Lycii extract 150g;
(2) mix homogeneously, adds lactose 150g, dextrin 120g, and magnesium stearate 30g, mixes, the ethanol water granulation agent that is 60% by volumetric concentration.
Pharmacodynamic experiment:
1, material and method:
1.1, experiment product: active compound part in resveratrol raw material, Radix Et Caulis Acanthopanacis Senticosi extract, Fructus Lycii extract and various embodiments of the present invention (6 embodiment all do not comprise adjuvant part).
1.2, laboratory animal: 0regon K wild type Drosophila melanogaster; Kunming mouse (approximately 54 weeks large, and this kind of mice life cycle is generally 2 years, is equivalent to the middle age for 54 weeks).
1.3, experiment grouping and medication:
Drosophila survival experiment: (by 3000 fruit bats, each 1500 of male and female, are divided into 10 groups at random, every group male and female each 150)
Experiment grouping:
Blank group (group 1),
Resveratrol folk prescription group (group 2),
Radix Et Caulis Acanthopanacis Senticosi extract folk prescription group (group 3)
Fructus Lycii extract folk prescription group (group 4)
The active compound group (being followed successively by group 5, group 6, group 7, group 8, group 9 and group 10) of embodiment 1-6
Medication: blank group does not add anything in feedstuff;
Resveratrol folk prescription group, Radix Et Caulis Acanthopanacis Senticosi extract folk prescription group, Fructus Lycii extract folk prescription group are added to above-mentioned three extracts in feedstuff respectively, make mass content be 20%; Test group 5-10 group is added to the active compound of embodiment 1-6 (compositions that step (1) obtains mixes) in feedstuff respectively, makes the mass content of each compositions be 20%.
Fruit bat is taken food naturally.
Mice existence test: 330 test mices of mice of 52 weeks large (being equivalent to the mankind's middle age) are divided into 11 groups, 30 every group at random.
The 1st group gives general diet, abbreviation group 1;
The 2nd group is added hydrogenated coconut oil in general diet, and making hydrogenated coconut oil mass content is 40%, abbreviation group 2;
The 3rd group gives and organizes 2 identical foods, adds resveratrol, and making resveratrol mass content is 20%;
The 4th group gives and organizes 2 identical foods, adds Radix Et Caulis Acanthopanacis Senticosi extract, and making Radix Et Caulis Acanthopanacis Senticosi mass content is 20%;
The 5th group gives and organizes 2 identical foods, adds Fructus Lycii extract, and making Fructus Lycii mass content is 20%;
6th, 7,8,9,10,11 groups give respectively and organize 2 identical foods, add successively the active compound (not comprising adjuvant) of embodiment 1-6, make its mass content be 20%.
1.4, experimental technique: learn assessment process and method of inspection specification with reference to function of health food. Ministry of Public Health version in 2003
1.5, statistical method: test data statistics all adopts variance analysis.
2, result of the test
2.1, drosophila survival experiment the results are shown in Table 1, result shows, three single preparations of ephedrine groups and the anti-apolexis composition that contains resveratrol of the present invention all can extend the survival day of female and Male Drosophila, but compositions of the present invention will obviously be better than three folk prescription groups, and there is significant differences (P < 0.01) with blank group, illustrate, the present composition has significant delaying senility function.
Table 1 drosophila survival experiment result
2.2, mice existence result of the test:
Table 2 mice existence result of the test
Table is found out thus, and resveratrol folk prescription, Radix Et Caulis Acanthopanacis Senticosi extract folk prescription, Fructus Lycii extract folk prescription and compositions of the present invention all can extend mice life, and three folk prescriptions are can life-saving about 11%, and compositions of the present invention can life-saving about 26%.
Claims (4)
1. contain an anti-apolexis composition for resveratrol, its crude drug is made up of the component of following weight portion: resveratrol 50-200 part; Radix Et Caulis Acanthopanacis Senticosi extract 40-150 part; Fructus Lycii extract 40-150 part.
2. a kind of anti-apolexis composition that contains resveratrol according to claim 1, is characterized in that described resveratrol is 80-180 part; Radix Et Caulis Acanthopanacis Senticosi extract is 60-120 part; Fructus Lycii extract is 60-120 part.
3. contain a preparation method for the anti-apolexis composition of resveratrol, it is characterized in that comprising the steps:
(1) take by weight: resveratrol 50-200 part; Radix Et Caulis Acanthopanacis Senticosi extract 40-150 part; Fructus Lycii extract 40-150 part;
(2) mix homogeneously, adds the acceptable adjuvant of pharmacy, makes capsule, granule or tablet.
4. the preparation method of a kind of anti-apolexis composition that contains resveratrol according to claim 3, is characterized in that described resveratrol is 80-180 part; Radix Et Caulis Acanthopanacis Senticosi extract is 60-120 part; Fructus Lycii extract is 60-120 part.
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| CN105879015A (en) * | 2014-10-23 | 2016-08-24 | 大连世纪新源技术开发有限公司 | Deuterium depleted water (DDW) oral liquid capable of preventing cancer and aging |
| CN104473996A (en) * | 2014-12-04 | 2015-04-01 | 莫海棠 | Resveratrol pharmaceutical composition and application thereof |
| CN104523996A (en) * | 2014-12-25 | 2015-04-22 | 天津市益倍建生物技术有限公司 | Resveratrol-containing composition having immunity enhancement effect and preparation containing composition |
| CN105596889A (en) * | 2016-01-22 | 2016-05-25 | 益倍（天津）生物科技有限公司 | Antitumor composition containing resveratrol and preparation method of antitumor composition |
| CN113521160A (en) * | 2021-08-30 | 2021-10-22 | 绿优品(福建)健康科技研发中心有限公司 | Refreshing and anti-fatigue composition and preparation method and application thereof |
| CN115317399A (en) * | 2022-07-07 | 2022-11-11 | 湖北真福医药有限公司 | Anti-aging composition and preparation method and application thereof |
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